IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q70EL2 | Q96EA4 | 1 | deubiquitination | up-regulates activity | 0.2 | Spindly is mono-ubiquitylated and this ubiquitin can be removed by active USP45. K48 ubiquitylated complex that interacts with Spindly is also de-ubiquitylated by USP45. In the absence of USP45 catalytic activity, interaction is abolished and cell migration is affected similarly to the phenotype described for lack of S... | SIGNOR-268505 |
Q14576 | Q12955 | 1 | post transcriptional regulation | down-regulates quantity | 0.25 | NElavl (composed of Elavl2, Elavl3, and Elavl4) proteins are the RNA-binding proteins that is specifically expressed in neurons, regulate the alternative splicing of target RNAs, and promote neuronal differentiation and maturation. Here, we found that the alternative splicing of AnkyrinG exon 34 was misregulated in th... | SIGNOR-266861 |
Q14191 | Q13535 | 0 | phosphorylation | down-regulates quantity | 0.794 | Importantly, ATR-mediated phosphorylation targets Werner syndrome protein for ubiquitination and degradation.|WRN is phosphorylated at serine 1141 by ATR in response to replication-associated DSBs A. WRN is heavily phosphorylated at S1141 in response to CPT treatment of cells. | SIGNOR-278159 |
O75367 | Q8IWR1 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Nuclear TRIM59 induces ubiquitination and degradation of the tumor suppressive histone variant macroH2A1, leading to enhanced STAT3 signaling activation and tumorigenicity. | SIGNOR-272931 |
P30679 | Q9GZQ4 | 2 | binding | up-regulates activity | 0.435 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257352 |
Q92520 | P42702 | 2 | binding | up-regulates activity | 0.2 | Interleukin-like EMT inducer (ILEI) a cytokine from the FAM3 family, also functions as a ligand for LIFR-gp130 heterodimer and mediates intracellular signal through STAT activation. | SIGNOR-277986 |
P41235 | P54646 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.367 | AMPK directly phosphorylates HNF4alpha and represses its transcriptional activity. AMPK-mediated phosphorylation of HNF4alpha on serine 304 had a 2-fold effect, reducing the ability of the transcription factor to form homodimers and bind DNA and increasing its degradation rate in vivo. Phosphorylation of HNF4α on Ser-3... | SIGNOR-250322 |
O95835 | P06493 | 0 | phosphorylation | up-regulates | 0.389 | Warts is a serine/threonine kinase and a dynamic component of the mitotic apparatus. We have found that cdc2/cyclin b forms a complex with a fraction of warts in the centrosome and phosphorylates the ser613 site of warts during mitosisit can be speculated that phosphorylation of warts by cdc2/cyclin b promotes a protei... | SIGNOR-94160 |
O95136 | P09471 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257007 |
Q15797 | Q8N4C8 | 0 | phosphorylation | down-regulates activity | 0.2 | Msn kinases directly phosphorylate α-helix 1 of Smad. we have identified Misshapen (Msn) and the mammalian orthologs TNIK, MINK1, and MAP4K4 as the kinases responsible for α-helix 1 phosphorylation. | SIGNOR-276336 |
P23443 | P06493 | 0 | phosphorylation | up-regulates | 0.384 | Interestingly, phosphorylation at several ser/thr residues within the c-terminal autoinhibitory tail appears to either activate or inhibit s6k1, depending on the cell cycle phase. phosphorylation of those residues (featured by the thr-421/ser-424 site) during mitosis pursued by cdk1 inactivates s6k1 we then assessed ... | SIGNOR-111507 |
Q9NXK8 | Q14012 | 1 | ubiquitination | down-regulates quantity | 0.475 | Here, we show that a ubiquitin E3 ligase component, F-box protein Fbxl12, mediates CaMKI degradation via a proteasome-directed pathway leading to disruption of cyclin D1/cdk4 complex. Endogenous Fbxl12 and CaMKI interacted as demonstrated after Fbxl12 immuno-precipitation followed by immunoblot analysis with CaMKI anti... | SIGNOR-261193 |
P19784 | Q15022 | 1 | phosphorylation | up-regulates activity | 0.2 | CK2 is the kinase for the phosphorylation of S583 of SUZ12. | SIGNOR-277797 |
O00444 | Q15154 | 1 | phosphorylation | up-regulates activity | 0.573 | Plk4‚Äêmediated phosphorylation of PCM1 at S372 is critical for the proper localisation of centriolar satellites, its dimer formation and interaction with other satellite components|Therefore, Plk4 is responsible for PCM1 phosphorylation at S372. | SIGNOR-279556 |
Q9UMX1 | Q8TBB1 | 0 | ubiquitination | down-regulates quantity | 0.2 | Indeed, they target different lysine residues in the SuFu protein, as LNX1 ubiquitinates SuFu at K59 and K470, and SCF Fbxl17 acts at K257, while Itch ubiquitinates at K321 and K457.|XREF_FIG, ectopic LNX1 expression reduced SuFu protein levels in HEK-293T cells, while shRNA mediated knockdown of LNX1 increased these l... | SIGNOR-278626 |
O60260 | Q00535 | 0 | phosphorylation | down-regulates | 0.2 | Phosphorylation by cdk5 decreased the auto-ubiquitylation of parkin both in vitro and in vivo. | SIGNOR-153445 |
Q8IWR1 | Q9BQ95 | 2 | binding | down-regulates activity | 0.518 | In this study, we showed that one of the TRIM family ubiquitin ligases, TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway. The B-box and RING domains of TRIM59 are important for interaction with ECSIT.|ECSIT enhances IPS-1-mediated IFN-Beta promoter activation.|Lucife... | SIGNOR-260369 |
P51813 | P25116 | 1 | phosphorylation | down-regulates activity | 0.2 | As shown in xref \u2013 xref , BMX overexpression increased PAR1-WT phosphorylation but had no effect on PAR1 Y 381 FY 383 F mutant, indicating that BMX phosphorylated PAR1 at Y 381 and Y 383 .|Mechanically , BMX represses PAR1 signaling in ECs by promoting PAR1 phosphorylation and internalization . | SIGNOR-279593 |
P78352 | P12931 | 0 | phosphorylation | up-regulates | 0.565 | These results indicate that psd-95 phosphorylation by src facilitates the integration of pyk2 to psd-95 signal complex, the activation of pyk2/src, as well as the subsequent tyrosine phosphorylation of nr2a, which ultimately results in the upregulation of nmda receptor function and synaptic transmission. | SIGNOR-205120 |
O96013 | O96013 | 2 | phosphorylation | up-regulates | 0.2 | Intracellular localization;enzymatic activity, induced;cell growth, altered; | SIGNOR-168301 |
P62837 | O95071 | 1 | ubiquitination | up-regulates activity | 0.508 | Using an in vitro reconstitution, specific E2 (ubiquitin-conjugating) enzymes (human UbcH4, UbcH5B, and UbcH5C) transferred ubiquitin molecules to hHYD, leading to the ubiquitination of TopBP1. TopBP1 was usually ubiquitinated and degraded by the proteosome, whereas X-irradiation diminished the ubiquitination of TopBP1... | SIGNOR-272668 |
P01137 | P02452 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.485 | COL1A1 expression is regulated by upstream genes and the binding of regulatory elements at multiple binding sites upstream of its promoter. During cancer progression, CAFs reorganize and cross-link COL1A1, which accumulates and stiffens in the tumor stroma [12], [18]. This process may involve fibrogenic factors, especi... | SIGNOR-277678 |
Q15139 | Q05655 | 0 | phosphorylation | up-regulates | 0.269 | Here we show that activation of pkd in response to oxidative stress requires two sequential signaling events, i.e., phosphorylation of tyr463 by abl, which in turn promotes a second step, phosphorylation of the pkd activation loop (ser738/ser742). We show that this is mediated by pkcdelta (protein kinase cdelta) | SIGNOR-123453 |
Q05655 | P05107 | 1 | phosphorylation | up-regulates | 0.329 | In this study, we present evidence that pkc isoforms are the major protein kinases that phosphorylate the c terminus of the integrin cd18 chain in leukocytes. Ser-745 is identified as a novel phosphorylation site in the integrin cytoplasmic domain. Additionally, we show that a thr-758-phosphorylated integrin peptide ca... | SIGNOR-178897 |
P25098 | Q13304 | 1 | phosphorylation | down-regulates activity | 0.2 | As depicted in Fig. 8 A and B, GRK2 silencing resulted in up-regulation of GPR17 and down-regulation of the mature markers CNPase and MBP, indicating a shift of cells toward a less differentiated stage.Having established that, in primary cultured OPCs, LTD 4 mediated desensitization of GPR17 through the primary recruit... | SIGNOR-279999 |
Q8NEZ5 | P04637 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.338 | We demonstrate here that SCFFbxo22-KDM4A is a senescence-associated E3 ligase targeting methylated p53 for degradation. We find that Fbxo22 is highly expressed in senescent cells in a p53-dependent manner, and that SCFFbxo22 ubiquitylated p53 and formed a complex with a lysine demethylase, KDM4A. |SCFFbxo22 forms a ter... | SIGNOR-273448 |
O43353 | Q9Y4K3 | 2 | binding | up-regulates activity | 0.685 | Binding of bacterial MDP or viral RNA to NOD2 results in the association of RIPK2 with TRAF6 and subsequent activation of TRAF6. | SIGNOR-280456 |
Q8TEW0 | Q05513 | 0 | phosphorylation | up-regulates | 0.711 | These results imply that serine 827 in the apkc binding site of par-3 is a target of apkc and that the regulated interaction between a protein kinase, apkc, and its substrate, par-3, plays an essential role in the establishment of cell polarity | SIGNOR-94523 |
O43791 | P10070 | 1 | ubiquitination | down-regulates quantity | 0.71 | RNAi knockdown of Spop (a substrate-binding adaptor for the cullin3-based ubiquitin E3 ligase) in Sufu mutant mouse embryonic fibroblasts (MEFs) can restore the levels of Gli2 and Gli3 full-length proteins | SIGNOR-268860 |
Q9NRM7 | P17612 | 0 | phosphorylation | up-regulates | 0.2 | Here, we show that cyclic amp (camp)-dependent protein kinase (pka) phosphorylates lats and thereby enhances its activity sufficiently to phosphorylate yap on ser381. | SIGNOR-236994 |
P62714 | O14757 | 1 | dephosphorylation | down-regulates activity | 0.266 | Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit|In response to genotoxic stress, Chk1 is phosphorylated on serines 317 (S317) and 345 (S345) by the ataxia-telangiectasia-related (ATR) protein kinase. Phosphorylation of Chk1 on these C-terminal serine residues is used as ... | SIGNOR-248578 |
Q07666 | P06213 | 0 | phosphorylation | up-regulates activity | 0.363 | Thus, Tyr phosphorylation of Sam68 by IR could modulate its association with the splicing machinery in a similar way to that described for p59 fyn, and this way, it could influence splice site selection. | SIGNOR-278946 |
P41743 | P61019 | 2 | binding | down-regulates activity | 0.456 | Rab2 Binds to the PKCι/λ Regulatory Domain and Inhibits PKCι/λ-dependent GAPDH Phosphorylation | SIGNOR-261301 |
P16949 | Q8NG68 | 2 | binding | down-regulates | 0.389 | Stathmin depresses ttl tubulin tyrosination activityin vitro. | SIGNOR-193465 |
Q9UBE8 | P46531 | 1 | phosphorylation | down-regulates | 0.382 | Nlk-phosphorylated notch1icd is impaired in its ability to form a transcriptionally_ active_ ternary_ complex. | SIGNOR-163697 |
Q8IUR6 | Q15011 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element. | SIGNOR-261575 |
O76050 | O76083 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A. We also demonstrate that NEURL1 can promote polyubiquitination of PDE9A that leads to its proteasome-mediated degradation mainly via lysine residue K27 of ubiquitin. | SIGNOR-272305 |
Q13569 | Q9NZJ0 | 2 | binding | down-regulates quantity by destabilization | 0.358 | TDG Is Polyubiquitinated by CRL4Cdt2 E3 Ubiquitin Ligase in a PIP Degron-dependent Manner | SIGNOR-272847 |
P54727 | P23025 | 2 | binding | up-regulates activity | 0.769 | GG-NER is initiated by the GG-NER specific factor XPC-RAD23B, in some cases with the help of UV-DDB (UV-damaged DNA-binding protein). TC-NER is initiated by RNA polymerase stalled at a lesion with the help of TC-NER specific factors CSA, CSB, and XAB2. Both pathways require the core NER factors to complete the excision... | SIGNOR-275697 |
O60216 | P23769 | 1 | relocalization | down-regulates activity | 0.325 | Large-scale AML genome re-sequencing efforts have identified novel recurrently mutated genes, including the members of the cohesin complex (RAD21, SMC3, SMC1A, and STAG2), implicated in the pathogenesis of this disease.Using ATAC-seq, we determined that mutant cohesin lead to a state of elevated chromatin accessibility... | SIGNOR-261513 |
P27694 | Q9UMS4 | 0 | polyubiquitination | up-regulates activity | 0.509 | PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). PRP19 ubiquitylates RPA and promotes ATRIP recruitment. | SIGNOR-272076 |
Q92783 | O60674 | 0 | phosphorylation | up-regulates | 0.617 | Stam is associated with jak3 and jak2 tyrosine kinases via its itam region and phosphorylated by jak3 and jak2 upon stimulation with il-2. | SIGNOR-47834 |
P19086 | P48039 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257101 |
Q14247 | Q8WZ74 | 2 | binding | up-regulates activity | 0.511 | Fluorescence recovery after photobleaching further suggested that CTTNBP2 modulates the mobility of cortactin in neurons. CTTNBP2 may thus help to immobilize cortactin in dendritic spines and control the density of dendritic spines. | SIGNOR-269703 |
Q969T4 | P25963 | 1 | sumoylation | up-regulates quantity by stabilization | 0.346 | In the presence of an E1 SUMO-1-activating enzyme, Ubch9 conjugated SUMO-1 to IkappaBalpha primarily on K21, which is also utilized for ubiquitin modification. Thus, SUMO-1-modified IkappaBalpha cannot be ubiquitinated and is resistant to proteasome-mediated degradation. | SIGNOR-270545 |
O43561 | P45983 | 0 | phosphorylation | down-regulates | 0.308 | Lat, an adapter protein essential for t-cell signaling, is phosphorylated at its thr 155 by erk in response to t-cell receptor stimulation. Thr 155 phosphorylation reduces the ability of lat to recruit plcgamma1 and slp76, leading to attenuation of subsequent downstream events such as [ca2+]i mobilization and activatio... | SIGNOR-125774 |
Q5JVS0 | P05771 | 0 | phosphorylation | down-regulates activity | 0.29 | We found a strong phosphorylation of Ki-1/57 by PKCalphabeta, PKCdelta, PKClambda/zeta, and especially by PKCsigma, however not by PKCmi. These data show that Ki-1/57 can serve in principal as a substrate for a wide variety of different PKC isoforms but also that its phosphorylation is strongest with PKCsigma. | This s... | SIGNOR-249247 |
P21399 | P17252 | 0 | phosphorylation | down-regulates | 0.2 | Irp1 ser-711 is a phosphorylation site, critical for regulation of rna-binding and aconitase activities. | SIGNOR-133188 |
P05112 | P31785 | 2 | binding | up-regulates | 0.858 | The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex | SIGNOR-108861 |
P23771 | P17676 | 2 | binding | down-regulates | 0.352 | In the present study, we demonstrate that both gata-2 and gata-3 form protein complexes with ccaat/enhancer binding protein alpha (c/ebpalpha) and c/ebpbeta, members of a family of transcription factors that are integral to adipogenesis. []the interaction between gata and c/ebp factors is critical for the ability of ga... | SIGNOR-132952 |
Q53EL6 | Q9Y297 | 0 | ubiquitination | down-regulates | 0.425 | Both akt and p70(s6k) phosphorylate pdcd4, allowing for binding of the e3-ubiquitin ligase beta-trcp and consequently ubiquitylation. | SIGNOR-160985 |
Q9UHD2 | O00571 | 1 | phosphorylation | up-regulates activity | 0.721 | Coexpression of TBK1 strongly increased the activity of DDX3X.|This suggests that DDX3X is rather specifically phosphorylated by TBK1 and IKK-i. | SIGNOR-278997 |
P10415 | Q86UR1 | 0 | null | down-regulates activity | 0.2 | BH3-only proteins containing only a single BH domain and including Puma, Noxa, Bid and Bad as well as other factors are particularly important for such neutralisation, binding and regulating the anti-apoptotic Bcl-2 proteins to promote apoptosis | SIGNOR-209684 |
Q9Y613 | Q13976 | 0 | phosphorylation | up-regulates | 0.354 | Pkgi also directly phosphorylates fhod1, and studies with wild-type and mutant fhod1-derived peptides identify ser-1131 in the fhod1 c terminus as the unique pkgi phosphorylation site in fhod1. phosphorylation of three conserved residues within the dad domain activates fhod1 while binding to rac regulates fhod1 subcell... | SIGNOR-123646 |
Q13618 | Q8N653 | 2 | binding | up-regulates activity | 0.273 | Leucine zipper-like transcriptional regulator 1 (LZTR1) encodes a member of the BTB-Kelch superfamily, which interacts with the Cullin3 (CUL3)-based E3 ubiquitin ligase complex. | SIGNOR-269070 |
Q96EB6 | P98177 | 1 | deacetylation | up-regulates | 0.744 | Deacetylation of foxos involves binding of the nad-dependent deacetylase hsir2(sirt1). Accordingly, hsir2(sirt1)-mediated deacetylation precludes foxo inhibition through acetylation and thereby prolongs foxo-dependent transcription of stress-regulating genes. | SIGNOR-124714 |
P24928 | Q9NP77 | 0 | dephosphorylation | up-regulates activity | 0.855 | Phosphorylation of serine-2 (S2) and serine-5 (S5) of the C-terminal domain (CTD) of RNA polymerase II (RNAP II) is a dynamic process that regulates the transcription cycle and coordinates recruitment of RNA processing factors. The Fcp1 CTD phosphatase catalyzes dephosphorylation of S2-P.| Depletion of Ssu72 impairs tr... | SIGNOR-248815 |
Q02750 | P28482 | 2 | phosphorylation | up-regulates activity | 0.75 | Mapk1 is phosphorylated by map2k1/mek1 and map2k2/mek2 on thr-185 and tyr-187 in response to external stimuli like insulin or ngf. Both phosphorylations are required for activity. | SIGNOR-236447 |
P17676 | Q8N695 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Luciferase reporter assays of deletion mutants of SLC5A8 promoter demonstrated that a 295-bp region is essential for the basal promoter activity of the SLC5A8 gene. Further analysis indicated that the CCAAT boxes and GC boxes were involved in positive regulation of SLC5A8 promoter. Overexpression of two transcription f... | SIGNOR-254054 |
Q99677 | P63092 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256785 |
P47900 | P38405 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256943 |
P06241 | Q16539 | 1 | phosphorylation | up-regulates | 0.489 | T cell src family kinases and zap70 activate p38 by phosphorylating tyr323. | SIGNOR-134293 |
P30989 | P34947 | 0 | phosphorylation | up-regulates activity | 0.594 | Here we report the unique phosphorylation\nof NTSR1 by GRK2 and GRK5, which belong to the GRK2 and GRK4 subfamilies,\nrespectively. | SIGNOR-278234 |
P19838 | P04150 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.6 | We have described how the receptor uses several means to achieve repression of the genes regulated by AP-1 and NF-KB proteins | SIGNOR-251680 |
P00519 | P29350 | 1 | phosphorylation | up-regulates activity | 0.414 | The results demonstrate that the SH3 domain of ABL1 interacts with a WPDHGVPSEP motif (residues 417-426) in the catalytic domain of SHPTP1 and that ABL1 phosphorylates C terminal Y536 and Y564 sites. | SIGNOR-260820 |
P67775 | P35222 | 1 | dephosphorylation | up-regulates | 0.462 | In the absence of the wt apc protein, phosphorylated beta-catenin is rapidly dephosphorylated by serine/threonine protein phosphatase 2a (pp2a). phosphorylated beta-catenin associated with the wild-type apc protein is recruited to the scf(beta-trcp) complex, ubiquitin conjugated, and degraded. | SIGNOR-182637 |
P55036 | Q05086 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.463 | S5a/Rpn10 is a ubiquitin (Ub)-binding protein that is a subunit of the 26S proteasome but also exists free in the cytosol. It binds poly-Ub chains through its two Ub-interacting motifs (UIMs). We discovered that, unlike typical substrates of Ub ligases (E3s), S5a can be ubiquitinated by all E3s tested including multime... | SIGNOR-272746 |
O14640 | O75084 | 2 | binding | up-regulates | 0.661 | In non-canonical Wnt signalling, Wnt proteins bind Fzd and glypican-4, to activate Dsh at the cell membrane, leading to activation of Rho and JNK | SIGNOR-255893 |
O43251 | O14920 | 0 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of RTA by IKKbeta increases RTA transcriptional activity and consequently viral mRNA production. | SIGNOR-279336 |
Q15121 | P31749 | 0 | phosphorylation | up-regulates activity | 0.517 | Protein kinase b/akt binds and phosphorylates ped/pea-15, stabilizing its antiapoptotic action. | SIGNOR-102092 |
Q13651 | P22301 | 2 | binding | up-regulates | 0.914 | Functionally active il-10 receptors are composed of two distinct subunits. The il-10 receptor ? Chain is a 110-kda polypeptide that plays the dominant role in mediating high affinity ligand binding and signal transduction. The il-10 receptor ? Subunit (also known as crf2_4) is predicted to be a 40-kda polypeptide that ... | SIGNOR-67964 |
P08754 | P35346 | 2 | binding | up-regulates activity | 0.45 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256833 |
P06744 | Q9UKV5 | 2 | binding | up-regulates | 0.53 | Pgi is a housekeeping gene encoding phosphoglucose isomerase (pgi) a glycolytic enzyme that also functions as a cytokine (autocrine motility factor (amf)/neuroleukin/maturation factor) upon secretion from the cell and binding to its 78 kda seven-transmembrane domain receptor (gp78/amf-r) | SIGNOR-97270 |
Q00535 | Q05397 | 1 | phosphorylation | up-regulates | 0.305 | Here, we show that fak phosphorylation by cdk5 at s732 is important for microtubule organization, nuclear movement, and neuronal migration. In cultured neurons, s732-phosphorylated fak is enriched along a centrosome-associated microtubule fork that abuts the nucleus. Overexpression of the nonphosphorylatable mutant fak... | SIGNOR-86223 |
P49757 | Q00987 | 2 | binding | down-regulates | 0.444 | Numb interacts with mdm2, and inhibits its ubiquitin-ligase function on tp53 (which in itself is inhibitory for tp53), thus numb activates (b) tp53 | SIGNOR-168454 |
P20807 | P49840 | 1 | cleavage | up-regulates activity | 0.2 | Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase | SIGNOR-251606 |
P30411 | P25098 | 0 | phosphorylation | down-regulates activity | 0.2 | Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GR... | SIGNOR-251445 |
P36894 | P12643 | 2 | binding | up-regulates | 0.929 | BMP interacts with specific receptors on the cell surface, BMP receptor types 1 and 2 (BMPr1 and BMPr2). | SIGNOR-253547 |
P21127 | Q07955 | 1 | phosphorylation | up-regulates activity | 0.283 | In comparison, CLK1 expression leads to speckle dissolution and diffuse GFP-SRSF1 localization in the nucleus.|We showed that CLK1 phosphorylates SRSF1 at approximately 18 sites inducing a gel shift from 35 to about 38 kDa on SDS-PAGE (XREF_FIG, upper panel). | SIGNOR-279499 |
Q13535 | Q8N163 | 1 | phosphorylation | up-regulates activity | 0.438 | Here, we report that, in human cell lines, DNA damage triggered the phosphorylation of DBC1 on Thr454 by ATM (ataxia telangiectasia-mutated) and ATR (ataxia telangiectasia and Rad3-related) kinases. Phosphorylated DBC1 bound to and inhibited SIRT1, resulting in the dissociation of the SIRT1-p53 complex and stimulating... | SIGNOR-267662 |
O00141 | P28482 | 1 | phosphorylation | up-regulates activity | 0.309 | SGK1 was found to physically interact with ERK1/2 as well as MEK1/2. Furthermore, SGK1 mediated the phosphorylation of ERK2 on Ser(29) in a serum-dependent manner. Replacement of Ser(29) to aspartic acid, which mimics the phosphorylation of Ser(29), enhanced the ERK2 activity as well as the MEK/ERK complexes formation. | SIGNOR-276223 |
P19174 | P35968 | 2 | binding | up-regulates | 0.675 | (vegfr) phosphorylated y1175 creates a binding site for phospholipase cgamma1 (plc-gamma1) | SIGNOR-147870 |
Q08828 | P63092 | 2 | binding | up-regulates activity | 0.627 | Because adenylyl cyclases are directly activated by G(s)alpha and the carboxyl termini of the various Galpha proteins determine their receptor coupling specificity, we proposed a set of chimeric G(s)alpha where the COOH-terminal five amino acids are replaced by those of other Galpha proteins and used these to dissect t... | SIGNOR-156958 |
Q13627 | P13807 | 1 | phosphorylation | down-regulates activity | 0.267 | DYRK Family Protein Kinases Phosphorylate and Inactivate Glycogen Synthase. both protein kinases phosphorylate site 3a but no other sites that affect glycogen synthase activity. | SIGNOR-260632 |
P38936 | O43293 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.316 | ZIP kinase phosphorylates p21(WAF1) at Thr145 and alanine-substituted mutations in the p21(WAF1) phosphorylation site alter its ability to be phosphorylated by ZIP kinase. | Transfected ZIPK can promote the phosphorylation of p21(WAF1) at Thr145 in vivo and can increase the half-life of p21(WAF1) | SIGNOR-251085 |
P05112 | O95644 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.549 | Recombinant NFAT1 can mediate transcription of the interleukin-2, interleukin-4, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor promoters in T cells, suggesting that NFAT1 contributes to the CsA-sensitive transcription of these genes during the immune response. | SIGNOR-254498 |
P06239 | P07766 | 1 | phosphorylation | up-regulates activity | 0.692 | Tyrosine Phosphorylation of CD8- Chimeras by Lck and ZAP-70 in COS Cells. both Y170F and Y181F chimeric proteins could be efficiently phosphorylated by Lck in vivo. phosphorylation of Y170 and Y181 within CD3- –ITAM provides to CD3- the potential to interact with multiple downstream effectors and signaling pathways. | SIGNOR-251369 |
Q92949 | P48380 | 2 | binding | up-regulates activity | 0.548 | RFX3 acts as a transcriptional co-activator to FOXJ1 that enhances the expression of cilia-associated genes. FOXJ1 is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 as a transcriptional co-activator to FOXJ1, helping to induce the expression of cilia genes in the process... | SIGNOR-266929 |
Q8WU20 | P04629 | 2 | binding | up-regulates | 0.779 | The signaling adapter frs-2 competes with shc for binding to the nerve growth factor receptor trka:a model for discriminating proliferation and differentiation | SIGNOR-65955 |
Q13153 | P16333 | 2 | binding | up-regulates activity | 0.709 | Both nck and grb4 proteins could associate with receptor tyrosine kinases and the sh3-binding proteins pak, sos1, and prk2, and they synergized with v-abl and sos to induce gene expression via the transcription factor elk-1. Association of nck with pak1 may serve to link this important regulatory kinase to cell activat... | SIGNOR-236512 |
Q5TZA2 | Q96CN5 | 2 | binding | up-regulates activity | 0.44 | Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. LRRC45 interacts with C-Nap1 and rootletin | SIGNOR-273704 |
O43318 | Q12933 | 0 | ubiquitination | up-regulates activity | 0.597 | Tumor necrosis factor receptor-associated factors 2 and 6 (traf2 and -6) act as the ubiquitin e3 ligases to mediate lys63-linked tak1 polyubiquitination at the lys158 residue in vivo and in vitro. Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue is required for TAK1-mediated IKK complex recruitment. | SIGNOR-162638 |
Q96GX5 | Q96GX5 | 2 | phosphorylation | up-regulates activity | 0.2 | After this priming step, Gwl can intramolecularly phosphorylate its C-terminal tail at pS883; this site probably plays a role similar to that of the tail/Z motif of other AGC kinases. | SIGNOR-243409 |
O43683 | Q8NG31 | 2 | binding | up-regulates | 0.2 | Association of the amino and middle domain of blinkin with the tpr domains in the amino termini of bubr1 and bub1 is essential for bubr1 and bub1 to execute their distinct mitotic functions | SIGNOR-158378 |
Q9UGL1 | O94992 | 0 | relocalization | up-regulates activity | 0.2 | We previously reported that the tumor suppressor HEXIM1 is a mediator of KDM5B recruitment to its target genes, and HEXIM1 is required for the inhibition of nuclear hormone receptor activity by KDM5B. | SIGNOR-273439 |
P31749 | P23769 | 1 | phosphorylation | down-regulates | 0.524 | We show that insulin induces gata2 phosphorylation on serine 401 in a pi-3k/akt-dependent manner. Insulin-dependent phosphorylation of serine 401 impairs gata2 translocation to the nucleus and its dna binding activity | SIGNOR-135614 |
P45985 | P45984 | 1 | phosphorylation | up-regulates | 0.729 | Mkk4, which activates p38gamma, p38delta, and jnk2 to phosphorylate p53 on ser-33 and cause a transient g(1) arrest. A map kinase kinase kinase (mapkkk), termed ask1, was identified that activated two different subs of map kinase kinases (mapkk), sek1 (or mkk4) and mkk3/mapkk6 (or mkk6), which in turn activated stress-... | SIGNOR-197998 |
P11309 | P42229 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.375 | The results of 2 microarray experiments demonstrated that the aberrant activation of STAT proteins by Flt3-ITDs resulted in the up-regulation of several STAT5-responsive genes, such as Pim-1, Pim-2, and members of the SOCS (suppressor of cytokine signaling) protein family. These results are particularly interesting bec... | SIGNOR-249621 |
Q8TEK3 | P01106 | 2 | binding | up-regulates activity | 0.334 | Our data suggest that the c-Myc-dependent transcriptional switch is modulated by DOT1L, as in the presence of DOT1L c-Myc preferentially forms an active complex with p300 rather than a repressive complex containing HDAC1 and DNMT1 | SIGNOR-239362 |
P55347 | P14653 | 2 | binding | up-regulates activity | 0.613 | we observe the formation of a ternary Prep1-Pbx1-HOXB1 complex on a HOXB1-responsive target in vitro. Interaction with Prep1 enhances the ability of the HOXB1-Pbx1 complex to activate transcription in a cooperative fashion from the same target. | SIGNOR-241215 |
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