IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q01201 | Q00653 | 2 | binding | up-regulates activity | 0.762 | The map3k14-activated chuk/ikka homodimer phosphorylates nfkb2/p100 associated with relb, inducing its proteolytic processing to nfkb2/p52 and the formation of nf-kappa-b relb-p52 complexes. The nf-kappa-b heterodimeric relb-p52 complex is a transcriptional activator. | SIGNOR-182835 |
P31749 | P06748 | 1 | phosphorylation | down-regulates activity | 0.534 | We find that AKT phosphorylation of NPM-Ser48 prevents oligomerization that results in nucleoplasmic localization of ARF, constitutive MDM2 inhibition and stabilization of p53. | SIGNOR-276667 |
Q9BXY4 | P31431 | 2 | binding | up-regulates | 0.422 | Here, we show that rspo3 binds syndecan 4 (sdc4) and that together they activate wnt/pcp signaling. | SIGNOR-172756 |
Q00535 | P63167 | 1 | phosphorylation | up-regulates activity | 0.2 | CDK5 activates the tumor suppressor DLC1 by phosphorylating and diminishing the binding of an autoinhibitory region of DLC1 to its Rho-GAP domain and allows it to localize to focal adhesions.|Here, we report that CDK5 coordinately activates multiple DLC1 functions, elucidate the mechanism underlying this activation, an... | SIGNOR-279154 |
O14965 | Q14863 | 1 | phosphorylation | down-regulates activity | 0.2 | Here, we report that Aurora kinase A phosphorylates mPOU at Ser197 and inhibit its DNA-binding ability. | SIGNOR-273546 |
Q14582 | Q9UQE7 | 2 | binding | down-regulates activity | 0.296 | We identified a novel ZIP-containing protein, Mmip1 (Mad member interacting protein 1) that strongly dimerizes with all four Mad members, but not with c-myc. Mmip1 can inhibit DNA binding by Max-Mad heterodimers and, in vivo, can reverse the suppressive eects of Mad proteins on c-myc functions. | SIGNOR-241284 |
Q9NZ72 | P49841 | 0 | phosphorylation | up-regulates activity | 0.264 | Altogether, these results indicate that CDK5 phosphorylates similarly serines 68 and 73, whereas ERK2 targets mostly serine 68 and GSK-3beta mostly serine 60.|This observation may support the hypothesis of a specific localization of stathmin 3 depending on its phosphorylation by GSK-3beta | SIGNOR-264882 |
Q96Q27 | P21333 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.442 | ASB2 is the specificity subunit of an E3 ubiquitin ligase complex and is proposed to exert its effects by regulating the turnover of specific proteins; however, no ASB2 substrates had been identified. Here, we report that ASB2 targets the actin-binding proteins filamin A and B for proteasomal degradation. | SIGNOR-271740 |
Q05655 | P53671 | 1 | phosphorylation | down-regulates | 0.256 | Activation of pkc by phorbol ester treatment of endothelial cells stimulated limk2 phosphorylation at ser-283 and inhibited nuclear import of limk2 | SIGNOR-137927 |
Q15208 | Q9Y5J3 | 1 | phosphorylation | up-regulates activity | 0.358 | We have identified two related kinases, STK38 (serine/threonine kinase 38) and STK38L (serine/threonine kinase 38 like), which interact with and phosphorylate HEY1 at Ser-68. | SIGNOR-279489 |
Q00535 | P48729 | 0 | phosphorylation | up-regulates activity | 0.297 | We also show that casein kinase I, but not casein kinase II, can phosphorylate and activate cdk5 in vitro. Ser(159) in cdk5 is homologous to the regulatory Thr(160) in cdk2. | SIGNOR-275966 |
Q96AC1 | P12931 | 2 | binding | up-regulates activity | 0.37 | Here we report that Src binds to and phosphorylates Kindlin-2 at Y193. Reciprocally, Kindlin-2-Y193 phosphorylation activates and maintains Src kinase activity. Kindlin-2-Y193 phosphorylation is also involved in its binding capacity with Migfilin and the recruitment of Migfilin to the focal adhesions. Functionally, we ... | SIGNOR-266101 |
P36897 | Q5SW24 | 2 | binding | down-regulates | 0.392 | Here, we provide evidence that unlike dpr1 that modulates wnt signaling, mdpr2 negatively regulates tgf-? Signaling and promotes tgf-? Receptor degradation in lysosomes. these results suggest that mdpr2 interferes with tgf-? By directly binding to and targeting the receptors for lysosomal inhibitor-sensitive degradati... | SIGNOR-151750 |
Q06187 | Q9UN19 | 1 | phosphorylation | up-regulates activity | 0.672 | We present a number of lines of evidence that in vivo, Src-type tyrosine kinases are responsible for the phosphorylation of tyrosine 139 in DAPP-1. | Although Btk appears to phosphorylate DAPP-1 relatively efficiently both in Sf9 cells and in vitro, we find no evidence that in either B cells or PAE cells Btk family kin... | SIGNOR-250602 |
O15287 | P06493 | 0 | phosphorylation | up-regulates | 0.355 | S387a mutant abolished fancg fusion protein phosphorylation by cdc2. | SIGNOR-129061 |
P36897 | Q9Y4K3 | 2 | binding | up-regulates activity | 0.428 | We report here that TRAF6 is specifically required for the Smad-independent activation of JNK and p38 and its carboxyl TRAF homology domain physically interacts with TGF-² receptors | SIGNOR-241918 |
P17252 | Q12791 | 1 | phosphorylation | up-regulates | 0.2 | Results showed that mutating s1076 altered the effect of pkc activation on bk(ca) channels in hek-293 cells | SIGNOR-186755 |
Q9UDY8 | Q5T447 | 0 | polyubiquitination | up-regulates quantity by stabilization | 0.366 | HECTD3 promotes MALT1 ubiquitination with nondegradative polyubiquitin chains by direct interacting with the MALT1 through its N-terminal destruction of cyclin domain. HECTD3 does not target MALT1 for degradation but stabilize it. | SIGNOR-272096 |
P17252 | P25098 | 1 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin. In vitro, GRK2 was preferentially phosphorylated by PKC isoforms alpha, gamma, and delta. Two-dimensional peptide mapping of PKCalpha-phosphorylated GRK2 showed a single site of phosphorylation, which was identified as serine 29 by HPLC... | SIGNOR-249058 |
P12931 | Q9Y2J4 | 2 | binding | up-regulates activity | 0.259 | These data support an idea that Amotl2 Tyr-103 can be phosphorylated by FGF receptor tyrosine kinase activity. We then determined whether Amotl2 Tyr-103 is required for its interaction with c-Src. |Amotl2 promotes MAPK/ERK activation via c-Src, which is dependent on phosphorylation of tyrosine residue at position 103 b... | SIGNOR-271870 |
P04637 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.495 | HUWE1 directly binds and ubiquitinates p53 to target it for proteasomal degradation, independently of MDM2 [ xref ]. | SIGNOR-278547 |
Q06124 | Q13224 | 1 | dephosphorylation | down-regulates activity | 0.469 | In addition, surface expression of GluN2B was not reduced in mutant mice and it remains to be investigated how the direct dephosphorylation of GluN2B Y1252 by Shp2 reduces GluN2B function.|The increased GluN2B Y1472 phosphorylation was reversed by a Src family kinase inhibitor, suggesting that Shp2 may negatively regul... | SIGNOR-276950 |
P50591 | Q9UBN6 | 2 | binding | down-regulates | 0.728 | One function of trail-r4 may be inhibition of trail cytotoxicy. Dcr2 functions as an inhibitory apo2l receptor. | SIGNOR-53447 |
Q13464 | P60484 | 1 | phosphorylation | up-regulates | 0.656 | In addition, active rhoa is able to stimulate the phospholipid phosphatase activity of pten in human embryonic kidney cells and leukocytes, and this regulation seems to require rhoa's downstream effector, rhoa-associated kinase (rock). together with the observation that individual substitution of ser 229 and thr 223 r... | SIGNOR-134855 |
P25116 | Q03113 | 2 | binding | up-regulates activity | 0.565 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257403 |
P51686 | O15444 | 2 | binding | up-regulates | 0.805 | Ccr9 is a specific receptor for the beta-chemokine teck/ccl25. | SIGNOR-104902 |
P49840 | Q969R2 | 1 | phosphorylation | up-regulates activity | 0.2 | CK1a1, JNK1 and CDK1 had the highest site-specific activity for ORP4L, while CDK1, GSK3a, CK1a1 and GSK3b showed the highest specificity for the site when corrected for background activity with ORP4L-S4A. Because of the complexity of the serine/proline-rich site, we did not determine which serine(s) in ORP4L were phosp... | SIGNOR-264875 |
Q9Y5X3 | P08069 | 2 | binding | down-regulates quantity | 0.269 | Here, we discovered that the binding between SNX-BARs and CI-MPR or IGF1R is mediated by the phox-homology (PX) domain of SNX5 or SNX6 and a bipartite motif, termed SNX-BAR-binding motif (SBM), in the cargoes. our studies establish that SNX-BARs function as a direct cargo-selecting module for a large set of transmembra... | SIGNOR-269444 |
P27361 | P61978 | 1 | phosphorylation | down-regulates | 0.345 | Erk phosphorylation drives cytoplasmic accumulation of hnrnp-k and inhibition of mrna translation mitogen-activated protein kinase/extracellular-signal-regulated kinase (mapk/erk) efficiently phosphorylates hnrnp-k both in vitro and in vivo at serines 284 and 353. | SIGNOR-145375 |
Q5JTC6 | P25054 | 1 | relocalization | up-regulates | 0.739 | Apc membrane recruitment protein 1 (amer1;alsoknownas wtx) | SIGNOR-199375 |
Q13131 | Q9GZY8 | 1 | phosphorylation | up-regulates activity | 0.2 | A screen for substrates of AMPK identified mitochondrial fission factor (MFF), a mitochondrial outer-membrane receptor for DRP1, the cytoplasmic guanosine triphosphatase that catalyzes mitochondrial fission. | SIGNOR-245953 |
O95831 | P04637 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.351 | P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In additio... | SIGNOR-267462 |
P07288 | P10275 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.822 | TH1 also associates with AR at the active androgen-responsive prostate-specific antigen (PSA) promoter in the nucleus of LNCaP cells. Decrease of endogenous AR protein by TH1 interferes with androgen-induced luciferase reporter expression and reduces endogenous PSA expression. | SIGNOR-253657 |
Q9NZQ7 | O43791 | 0 | ubiquitination | down-regulates quantity | 0.325 | Loss-of-function mutations in SPOP compromise ubiquitination-mediated PD-L1 degradation, leading to increased PD-L1 levels and reduced numbers of tumor-infiltrating lymphocytes (TILs) in mouse tumors and in primary human prostate cancer specimens. | SIGNOR-274978 |
Q9NZJ5 | O15294 | 1 | phosphorylation | up-regulates activity | 0.2 | Collectively, these results indicate that upon cold and \u03b2-adrenergic stimulation PERK-activated OGT catalyzes the O-GlcNAcylation of CK2\u03b1 and TOM70 which enhances MIC19 import into the mitochondria increasing cristae formation and cell respiration (Figure 7I).|Here, we report that the ER-resident kinase PERK ... | SIGNOR-279736 |
Q99677 | P50148 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257383 |
Q13153 | P23975 | 1 | phosphorylation | down-regulates activity | 0.2 | PAK1 negatively regulates the activity of the Rho exchange factor NET1.|Specifically, PAK1 phosphorylates NET1 on three sites in vitro : serines 152, 153, and 538. | SIGNOR-280054 |
O75531 | Q99986 | 0 | phosphorylation | down-regulates | 0.877 | We demonstrate that phosphorylation of ser4 and/or thr2/thr3 abrogates the interaction of baf with dna and reduces its interaction with the lem domain. Coexpression of vrk1 and gfp-baf greatly diminishes the association of baf with the nuclear chromatin/matrix and leads to its dispersal throughout the cell | SIGNOR-144783 |
O15550 | P49639 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.403 | Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. | SIGNOR-260019 |
O75582 | P35222 | 1 | phosphorylation | up-regulates activity | 0.2 | Co-transfection of MSK1 increased beta-catenin transcriptional activity in a dose dependent manner (XREF_FIG).|Our in vitro kinase assay showed that MSK1 can directly phosphorylate beta-catenin at Ser 552. | SIGNOR-278247 |
Q9UGM6 | P18848 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.246 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269430 |
Q5T0T0 | P08195 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Taken together, these findings demonstrate that MARCH8 directly ubiquitinates CD98, and this likely leads to its routing to late endosomes for degradation. | SIGNOR-272755 |
P43320 | P26998 | 2 | binding | up-regulates activity | 0.453 | At high concentrations or in the lens, βB2-crystallin forms hetero-oligomers with other β-crystallins. These oligomeric β-crystallins further participate in the formation of a supramolecular assembly that is important in lens function-lens transparency. | SIGNOR-252152 |
Q8IZJ1 | P43146 | 2 | binding | down-regulates activity | 0.658 | In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion ... | SIGNOR-268166 |
Q13131 | Q9UBK2 | 1 | phosphorylation | up-regulates activity | 0.575 | Ampk phosphorylates pgc-1alpha directly both in vitro and in cells. These direct phosphorylations of the pgc-1alpha protein at threonine-177 and serine-538. | SIGNOR-156780 |
Q86Y13 | Q7L7L0 | 1 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271757 |
P08949 | P28336 | 2 | binding | up-regulates | 0.767 | These neuropeptides, including gastrin-releasing peptide, neuromedin b, neurotensin, gastrin, cholecystokinin and arginine vasopressin bind seven transmembrane-spanning receptors that couple to heterotrimeric g proteins. | SIGNOR-107022 |
P37802 | P28482 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.269 | ERK2 interacted with 29-31 amino acids of transgelin-2 and subsequently phosphorylated the S145 residue of transgelin-2. S145 phosphorylation of transgelin-2 played important roles in cell proliferation and tumorigenesis of PDAC.| We found that the protein stability of transgelin-2 was regulated by KRAS. ERK-mediated p... | SIGNOR-265221 |
Q13541 | P28482 | 0 | phosphorylation | down-regulates activity | 0.659 | The 4E-BPs inhibit translation in a reversible manner. Hypophosphorylated 4E-BPs interact avidly with eIF4E, whereas 4E-BP hyperphosphorylation, elicited by stimulation of cells with hormones, cytokines, or growth factors, results in an abrogation of eIF4E-binding activity.|These results are at variance with reports th... | SIGNOR-249390 |
P62993 | Q15303 | 2 | binding | up-regulates | 0.83 | Egfr and erbb4 had several docking sites for grb2, while erbb3 was characterized by six binding sites for pi3k. Egfr has six binding sites for the adapter protein grb2, and erbb4 has five, each with different binding strength. | SIGNOR-146876 |
P07900 | Q99538 | 2 | binding | up-regulates quantity by stabilization | 0.2 | We demonstrate that TRAF6 ubiquitinates the proform of AEP through K63-linked polyubiquitin, reversible by USP17, and forms a complex with HSP90α to subsequently promote pro-AEP intracellular stability as well as secretion. We now present evidence that AEP is a substrate for TRAF6 ubiquitination, resulting in AEP/TRAF6... | SIGNOR-272855 |
Q9HCX3 | P42772 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.28 | Finally, we show that ZNF304 also directs transcriptional silencing of INK4-ARF in human embryonic stem cells. | SIGNOR-266099 |
Q14623 | Q96QV1 | 2 | binding | down-regulates activity | 0.713 | Hip encodes a membrane glycoprotein that binds to all three mammalian hedgehog proteins with an affinity comparable to that of ptc-1. our findings support a model in which hip attenuates hedgehog signalling as a result of binding to hedgehog proteins: a negative regulatory feedback loop established in this way could th... | SIGNOR-65075 |
Q9ULV1 | O75197 | 2 | binding | up-regulates activity | 0.704 | Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain. | SIGNOR-258967 |
P62820 | O60763 | 2 | binding | up-regulates activity | 0.798 | Here, the tethering factor p115 was shown to be a Rab1 effector that binds directly to activated Rab1. | SIGNOR-261287 |
Q9NXA8 | P34897 | 1 | post translational modification | down-regulates activity | 0.235 | Mitochondrial serine hydroxymethyl transferase (SHMT2) is a rate-limiting enzyme that catalyzes the catabolism of serine and drives the proliferation of osteosarcoma cells and colon cancer cells. SIRT5 directly mediates the desuccinylation of Lysine 280 on SHMT2. Therefore, SIRT5 is a candidate target to inhibit serine... | SIGNOR-267644 |
P19086 | P21728 | 2 | binding | up-regulates activity | 0.269 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257269 |
Q13164 | Q92886 | 1 | phosphorylation | up-regulates activity | 0.35 | Activation of ERK5 potentiates while inhibition of ERK5 attenuates Neurog1 stimulated neurogenesis.|ERK5 directly phosphorylated Neurog1 in vitro and modulated the transcriptional and pro-neural activity of Neurog1 in cortical progenitors. | SIGNOR-278364 |
P08253 | P01137 | 1 | cleavage | up-regulates | 0.555 | We also demonstrate that mmp-9, as well as its relative, mmp-2, cleave latent transforming growth factor-beta (tgf-beta), which constitutes a novel mechanism of tgf-beta activation | SIGNOR-74384 |
P22223 | O60716 | 2 | binding | up-regulates quantity by stabilization | 0.751 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252124 |
P07766 | P06239 | 0 | phosphorylation | up-regulates activity | 0.692 | Tyrosine Phosphorylation of CD8- Chimeras by Lck and ZAP-70 in COS Cells. both Y170F and Y181F chimeric proteins could be efficiently phosphorylated by Lck in vivo. phosphorylation of Y170 and Y181 within CD3- –ITAM provides to CD3- the potential to interact with multiple downstream effectors and signaling pathways. | SIGNOR-251369 |
Q9H9S0 | Q9H9S0 | 2 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We conclude that the Nanog enhancer activity is regulated by both Sall4 and Nanog. | SIGNOR-266080 |
P16333 | P09619 | 2 | binding | up-regulates | 0.638 | Growth factor binding to receptor protein tyrosine kinases (r-ptks)1 induces their dimerization and trans-phosphorylation, creating docking sites for proteins containing sh2 and ptb protein interaction domains. Nck binds to the pdgf and egfr receptors (figure 3c). | SIGNOR-64737 |
O95429 | P19438 | 2 | binding | down-regulates activity | 0.647 | It was suggested that the silencer of death domains (SODD) protein constitutively associates intracellularly with TNFR1 and inhibits the recruitment of cytoplasmic signaling proteins to TNFR1 to prevent spontaneous aggregation of the cytoplasmic death domains of TNFR1 molecules that are juxtaposed in the absence of lig... | SIGNOR-245022 |
Q9Y4B6 | Q9NRM7 | 2 | binding | down-regulates quantity by destabilization | 0.2 | CRL4 DCAF1 ubiquitylates and inhibits Lats. | SIGNOR-272227 |
P33993 | O00311 | 0 | phosphorylation | up-regulates | 0.942 | We propose that phosphorylation of mcm4/6 s/tp sites, which are already phosphorylated in g1, allows initial mcm2-7 phosphorylation by ddk and initiation from the first origins of replication ( fig. 7ai ). | SIGNOR-169506 |
Q13362 | P18846 | 1 | dephosphorylation | up-regulates | 0.2 | We propose that constitutive hyperphosphorylation by ck1/ck2 maintains atf1 in an inactive state that promotes transcriptional repression. Pp2a/b56c antagonizes phosphorylation of atm sites in both creb and atf5 | SIGNOR-167564 |
P37231 | P18146 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.62 | Previous studies have reported that the PPARγ proximal promoter contains an overlapping binding site for Egr-1, which is involved in the down-regulation of PPARγ. In the present study, we have provided direct evidence that leptin causes PPARγ reduction in primary cultured PASMC; this effect is coupled to leptin-induced... | SIGNOR-263508 |
P15374 | Q06609 | 1 | deubiquitination | up-regulates activity | 0.325 | Here we report that ubiquitination of RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination of RAD51 facilitates RAD51-BRCA2 binding and RAD51 recruitment and thus is critical for proper HR. | UCHL3, in turn, deubiquitinates RAD51 and promotes the binding between RAD51 and BRCA2.|Our results suggested that thre... | SIGNOR-275908 |
Q9Y4G8 | Q9NYY3 | 0 | phosphorylation | up-regulates activity | 0.357 | Here, we report that Plk2 phosphorylates a quartet of Ras and Rap regulators : SynGAP, PDZGEF1, RasGRF1 and SPAR, resulting in powerful bidirectional control over Rap and Ras activity.|Thus, Plk2 was sufficient to promote the activities of both SynGAP and PDZGEF1 in mammalian cells. | SIGNOR-280066 |
Q12756 | P0DP25 | 2 | binding | up-regulates activity | 0.27 | To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2. We showed that calcium, acting via CaM, enhances KIF1A... | SIGNOR-266890 |
P35575 | P04150 | 0 | transcriptional regulation | up-regulates quantity | 0.2 | Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB | SIGNOR-256104 |
P42336 | P62873 | 2 | binding | up-regulates | 0.564 | Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt | SIGNOR-145119 |
Q13698 | P17612 | 0 | phosphorylation | up-regulates activity | 0.346 | To identify the regulatory sites of phosphorylation under physiologically relevant conditions, Ca(V)1.1 channels were purified from skeletal muscle and sites of phosphorylation on the α1 subunit were identified by mass spectrometry. Two phosphorylation sites were identified in the proximal C-terminal domain, serine 157... | SIGNOR-263112 |
Q13464 | P07737 | 1 | phosphorylation | down-regulates | 0.272 | We previously identified pfn1 as a huntingtin aggregation inhibitor, and others have implicated it as a tumor-suppressor. Rho-associated kinase (rock) directly phosphorylates pfn1 at ser-137 to prevent its binding to polyproline sequences. This negatively regulates its anti-aggregation activity. | SIGNOR-196820 |
P46531 | Q9BWU1 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.302 | Mapping of cyclin C-dependent phosphosites on ICN1, using mass spectrometry revealed that several of them are located within the PEST-domain of Notch1, which controls ICN1 degradation38,39 (Fig. 5g and Supplementary Table 1). Three of them (T2512, S2514 and S2517) are localized within the consensus motif, “Cdc4 phospho... | SIGNOR-273135 |
P12643 | P36894 | 2 | binding | up-regulates | 0.929 | BMP interacts with specific receptors on the cell surface, BMP receptor types 1 and 2 (BMPr1 and BMPr2). | SIGNOR-253547 |
P42684 | P17676 | 1 | phosphorylation | up-regulates | 0.274 | The y79 amino acid residue of c/ebpbeta was phosphorylated by c-abl or arg. The phosphorylation of c/ebpbeta resulted in an increased c/ebpbeta stability and a potentiation of c/ebpbeta transcription activation activity in cells | SIGNOR-186427 |
Q8TAQ2 | P51532 | 2 | binding | up-regulates | 0.939 | The remodeling activity of brg1 and hbrm is stimulated by baf170/baf155 and is further stimulated when ini1 is added. | SIGNOR-65444 |
Q9HCK8 | O96020 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.417 | In order to identify CHD8 target genes, we performed a transcriptomic analysis of CHD8-depleted cells, finding out that CHD8 controls the expression of cyclin E2 (CCNE2) and thymidylate synthetase (TYMS), two genes expressed in the G1/S transition of the cell cycle. CHD8 was also able to co-activate the CCNE2 promoter ... | SIGNOR-268804 |
Q99808 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | These data suggest that inhibition of CK2-mediated phosphorylation at Ser254 had the same effect on transporter function as the actual loss of Ser254 in mENT1a, implying that this site is constitutively phosphorylated by CK2. | SIGNOR-276063 |
P35611 | P17252 | 0 | phosphorylation | up-regulates | 0.2 | These data demonstrate that adducin is a significant in vivo substrate for pkc or other pma-activated kinases in a variety of cells, and that phosphorylation of adducin occurs in dendritic spines that are believed to respond to external signals by changes in morphology and reorganization of cytoskeletal structures. Ser... | SIGNOR-43744 |
Q13535 | Q96PY6 | 2 | binding | up-regulates activity | 0.2 | It was reported that NEK1 associates with ATR/ATRIP and primes it for activation in response to a variety of genotoxic agents | SIGNOR-275841 |
O00311 | P06493 | 0 | phosphorylation | up-regulates | 0.535 | Hucdc7 and ask proteins can also be phosphorylated by cdks in vitro. Among four possible cdk phosphorylation sites of hucdc7, replacement of thr-376, corresponding to the activating threonine of cdk, with alanine (t376a mutant) dramatically reduces kinase activity, indicative of kinase activation by phosphorylation of ... | SIGNOR-78311 |
O60381 | Q16539 | 0 | phosphorylation | up-regulates | 0.43 | A mutation of the p38 map kinase phosphorylation site at aa 401 [(s-a)401hbp1] also triggered hbp1 protein instability. While protein stability was compromised by mutation, the specific activities of (s-a)401hbp1 and of wild-type hbp1 appeared comparable for transcriptional repression. | SIGNOR-119138 |
P35712 | Q9BS16 | 2 | binding | up-regulates activity | 0.47 | Here we report the cloning of a novel cDNA, termed Solt, from a mouse testis cDNA library. Its gene product, Solt, interacts with the leucine zipper region of SoxLZ/Sox6. In transient transfection assays with SoxLZ/Sox6 containing the transactivation domain of herpes simplex virus VP16, the expression of a luciferase ... | SIGNOR-221820 |
Q9Y6W6 | Q14653 | 1 | dephosphorylation | down-regulates activity | 0.2 | The inactivation of IRF3 by MKP5 is dependent on MKP5 phosphatase activity or its binding to IRF3.|This is confirmed since MKP5 phosphatasedeficient mutant is unable to dephosphorylate IRF3 and MKP5 mutant lacking IRF3 binding motifs fails to suppress IRF3 nuclear translocation upon virus infection. | SIGNOR-277146 |
P41743 | Q92934 | 1 | phosphorylation | down-regulates | 0.32 | In-vitro kinase activity assay showed that pkc-_ directly phosphorylated bad at phospho specific residues, ser-112, ser-136 and ser-155 which in turn induced inactivation of bad and disruption of bad/bcl-xl dimer | SIGNOR-172894 |
P40763 | P06239 | 0 | phosphorylation | up-regulates activity | 0.699 | Lck was able to induce tyrosine phosphorylation of STAT3 to a level equal to or greater than that induced by Jak2.|This finding, along with the previous data, gives strong evidence that Lck can directly and positively affect STAT3 activity.Our data provide strong evidence that Lck can activate STAT3 via phosphorylation... | SIGNOR-279201 |
O95180 | P37088 | 2 | binding | up-regulates activity | 0.2 | This study describes the functional interaction between Cav3.2 calcium channels and the Epithelial Sodium Channel (ENaC). β- and γ-ENaC subunits could be co-immunoprecipitated with Cav3.2 calcium channels from brain lysates, dorsal horn and lumbar dorsal root ganglia. Αβγ-ENaC channels enhanced Cav3.2 calcium channel ... | SIGNOR-269272 |
P06748 | Q7Z419 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | NPMc degradation was mediated by the ubiquitin-proteasome pathway involving the IBR-type RING-finger E3 ubiquitin ligase IBRDC2, and genetic correction of FA-A or FA-C lymphoblasts prevented NPMc ubiquitination. As shown in Fig. 4C, knockdown of IBRDC2, an IBR-type RING-finger E3 ubiquitin ligase (21), significantly r... | SIGNOR-271490 |
Q01094 | P50613 | 0 | phosphorylation | down-regulates | 0.493 | These results suggest that tfiih-mediated phosphorylation of e2f-1 plays a role in triggering e2f-1 degradation during s phase. here we show that the e2f-1 activation domain interacts with a kinase activity which phosphorylates two sites, ser403 and thr433, within the activation domain. | SIGNOR-69776 |
Q03393 | Q13976 | 0 | phosphorylation | up-regulates | 0.257 | Upon expression in cos-1 cells, ptps-s19a was stable but not phosphorylated and had a reduced activity of approximately 33% in comparison to wild-type ptps. Addition of cgmp stimulated phosphotransferase activity 2-fold. Extracts from transfected cos-1 cells overexpressing cgkii stimulated ser(19) phosphorylation more ... | SIGNOR-71680 |
P29317 | O14493 | 1 | phosphorylation | down-regulates activity | 0.477 | EphA2 associates with claudin-4 via their extracellular domains. This association, in turn, leads to phosphorylation of the cytoplasmic carboxyl terminus of claudin-4 at Tyr-208. The tyrosine phosphorylation of claudin-4 attenuates association of claudin-4 with ZO-1, decreasing integration of claudin-4 into sites of ce... | SIGNOR-262859 |
Q6WCQ1 | O75688 | 0 | dephosphorylation | down-regulates activity | 0.2 | Ppm1b prevents Rip3 auto-activation in resting cells.|Together, these data demonstrate that Ppm1b dephosphorylates Rip3 and thus negatively regulates TNF induced necroptosis in L929 cells. | SIGNOR-277019 |
O14965 | Q13153 | 0 | phosphorylation | up-regulates | 0.417 | The upstream pak1 kinase can phosphorylate aurora a at t288, autophosphorylation appears to be the essential mode of activation. Our experiments suggest that phosphorylation of t288 is important for regulation of the aurora2 kinase both for its activity and its stability | SIGNOR-205110 |
P42574 | Q13635 | 1 | cleavage | down-regulates | 0.321 | Like other dependence receptors, ptc1 contains a dependence-as-associated receptor c-terminal motif that is cleaved by caspases at a conserved aspartic acid (asp 1392) in the absence of shh, to expose a proapoptotic domain. | SIGNOR-199111 |
Q13200 | Q92918 | 0 | phosphorylation | up-regulates activity | 0.2 | Seven of these kinases (PIM1/2/3, MAP4K1/2, PKA, and NEK6) directly and robustly phosphorylated recombinant GST-Rpn1 at S361 in vitro (Fig. 3D and SI Appendix, Fig. S3 A and B). | SIGNOR-273899 |
P21462 | O95837 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256961 |
Q01543 | Q05655 | 0 | phosphorylation | down-regulates | 0.346 | We have previously demonstrated that in response to transforming growth factor _ (tgf_), fli-1 activity is repressed through a series of sequential posttranslational modifications, consisting of protein kinase c_ (pkc_)-induced thr312 phosphorylation, acetylation by p300/creb binding protein-associated factor, and deta... | SIGNOR-172113 |
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