IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P09471 | Q92847 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257255 |
P08754 | O43193 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256880 |
Q13153 | Q00535 | 0 | phosphorylation | down-regulates activity | 0.54 | Our previous work revealed that the neuronal p35/Cdk5 kinase associates with Pak1 in a RacGTP-dependent manner, causing hyperphosphorylation and down-regulation of Pak1 kinase activity. We have now demonstrated direct phosphorylation of Pak1 on threonine 212 by the p35/Cdk5 kinase. | SIGNOR-249328 |
P01106 | Q969H0 | 0 | ubiquitination | down-regulates quantity | 0.762 | We now show that the F-box protein Fbw7 interacts with and thereby destabilizes c-Myc in a manner dependent on phosphorylation of MB1. Whereas wild-type Fbw7 promoted c-Myc turnover in cells, an Fbw7 mutant lacking the F-box domain delayed it. | SIGNOR-243545 |
P0C6X7 | P17844 | 2 | binding | up-regulates activity | null | To our knowledge, this is the first report to show that SARS-CoV helicase can interact directly with multifunctional protein Ddx5 in cell culture and that inhibition of Ddx5 results in the suppression of viral replication. We speculate that Ddx5 may act as a coactivator by direct binding to the SARS-CoV helicase, resul... | SIGNOR-260250 |
Q9UHV7 | P49336 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.901 | Here, cyclin C-Cdk8 phosphorylation of Med13 most likely primes the phosphodegron for destruction. | SIGNOR-279687 |
Q9Y4K3 | P49768 | 1 | ubiquitination | up-regulates quantity by stabilization | 0.559 | We have also observed that ubiquitination of PS1 by TRAF6 increases the stability of PS1 holoprotein, and TRAF6-deficiency coincides with reduced endogenous PS1 and PS2 levels. | SIGNOR-278601 |
P23511 | P08047 | 2 | binding | up-regulates activity | 0.617 | Our results further confirm the important transactivating role for NF-Y for the CBS-1b promoter, via its synergism with Sp1. While differential phosphorylation of Sp1 likely contributes to binding to multiple GC-/GT-boxes in the CBS-1b and promoter activation [16], NF-Y is clearly necessary for a maximal activation res... | SIGNOR-254816 |
Q9H9Z2 | P27361 | 0 | phosphorylation | down-regulates activity | 0.277 | Here we show that Lin28a is directly phosphorylated by ERK1/2 kinases at Ser-200. | SIGNOR-277337 |
O43609 | Q06124 | 0 | dephosphorylation | down-regulates | 0.409 | These results identify sprouty proteins as in vivo targets of corkscrew/shp-2 tyrosine phosphatases and show how corkscrew/shp-2 proteins can promote rtk signaling by inactivating a feedback inhibitor. | SIGNOR-144547 |
Q96BR1 | Q96PU5 | 1 | phosphorylation | down-regulates activity | 0.445 | Moreover, S422DSGK1, SGK1, and SGK3 also phosphorylated Nedd4-2 and thereby inhibited Nedd4-2 binding to its target. | SIGNOR-280125 |
P63092 | P41594 | 2 | binding | up-regulates activity | 0.357 | MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G p... | SIGNOR-264078 |
P22670 | P00519 | 2 | binding | up-regulates | 0.2 | We show that rfxi and c-abl are in direct interaction, in vitro and in cell extracts, through the rfxi proline rich (pxxp) motif and the c-abl sh3 domain. Remarkably, this interaction significantly potentiates c-abl but not v-abl auto-kinase activity | SIGNOR-57516 |
Q12923 | Q9BUL8 | 1 | dephosphorylation | down-regulates activity | 0.567 | In addition, our yeast two-hybrid analysis revealed that CCM3 also binds to the 270-kDa nonreceptor protein tyrosine phos- phatase FAP-1 in a region predicted to contain the C- terminal phosphatase domain [23]. We have shown that this catalytic domain is capable to dephosphorylate CCM3. By dephosphorylation, FAP-1 migh... | SIGNOR-248714 |
P32239 | P38405 | 2 | binding | up-regulates activity | 0.265 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256908 |
Q9UPN9 | P84022 | 2 | binding | up-regulates activity | 0.586 | The ubiquitious nuclear protein transcriptional intermediary factor 1gamma (tif1gamma) selectively binds receptor-phosphorylated smad2/3 in competition with smad4. Rapid and robust binding of tif1gamma to smad2/3 occurs in hematopoietic, mesenchymal, and epithelial cell types in response to tgfbeta. Tif1gamma mediates ... | SIGNOR-236060 |
P34947 | P30411 | 1 | phosphorylation | down-regulates activity | 0.489 | Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GR... | SIGNOR-251208 |
P49841 | Q05516 | 1 | phosphorylation | up-regulates activity | 0.2 | Taken together, we conclude that S184 and T282 of ZBTB16 may be phosphorylated by GSK3beta in cells under serum starvation condition. | SIGNOR-279618 |
P30550 | P63092 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256774 |
P38936 | Q13207 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.345 | TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et a... | SIGNOR-249593 |
O95260 | P11021 | 1 | post transcriptional regulation | down-regulates quantity by destabilization | 0.295 | We showed that the molecular chaperone BiP (also known as GRP78) was short-lived under basal conditions and ER stress. The turnover of BiP was in part driven by its amino-terminal arginylation (Nt-arginylation) by the arginyltransferase ATE1, which generated an autophagic N-degron of the N-end rule pathway. | SIGNOR-261345 |
Q93009 | P60484 | 1 | deubiquitination | down-regulates activity | 0.741 | BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP|hese data indicate that BCR-ABL phosphorylation of HAUSP modulates HAUSP’s deubiquitinase activity toward PTEN. | SIGNOR-276533 |
Q06547 | P51610 | 2 | binding | down-regulates activity | 0.328 | The C1 factor interacts with the GABP_ transactivation domain.The domain of the C1 factor required for C1GABP interaction can inhibit GABP_dependent transcriptional activation | SIGNOR-221377 |
P32248 | P32121 | 1 | relocalization | up-regulates activity | 0.377 | B-Arrestin-2 is recruited to CCR7 following stimulation with CCL19, but not CCL21. | SIGNOR-278124 |
P38405 | Q9UBY5 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256747 |
Q14980 | Q9UHD2 | 0 | phosphorylation | up-regulates activity | 0.2 | Our studies now reveal TBK1 as another kinase that phosphorylates NuMA and that is required for its association with dynein and for localization of NuMA to the centrosomes in mitotic cells. | SIGNOR-278432 |
Q8IUC6 | Q9NR30 | 2 | binding | up-regulates activity | 0.266 | We demonstrated here that DDX1-DDX21-DHX36 represents a dsRNA sensor that uses the adaptor molecule TRIF to activate the NF-κB pathway and type I IFN responses in dendritic cells. Our study suggests that the DDX1-DDX21-DHX36 complex represents this missing poly I:C sensor, which uses DDX1 to bind poly I:C and uses DDX... | SIGNOR-260192 |
P09211 | P05771 | 0 | phosphorylation | up-regulates activity | 0.2 | Peptide phosphorylation analyses and both phosphorylation and enzyme kinetic studies with GSTP1 proteins mutated at candidate amino acid residues established Ser-42 and Ser-184 as putative phospho-acceptor residues for both kinases in the GSTP1 protein. Together, these findings show PKA- and PKC-dependent phosphorylati... | SIGNOR-276023 |
P24941 | O14519 | 2 | binding | down-regulates activity | 0.441 | The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2, making it an important component of cell cycle regulation during G1-to-S phase transition. | SIGNOR-264781 |
P45983 | Q01974 | 2 | binding | up-regulates | 0.46 | Wnt5a stimulation induces activation of the c-jun n-terminal kinase jnk at the wound edge in a ror2-dependent manner, and inhibiting jnk activity abrogates wnt5a-induced lamellipodia formation and mtoc reorientation | SIGNOR-179671 |
Q7Z569 | Q9Y4E8 | 2 | ubiquitination | down-regulates quantity by destabilization | 0.267 | Here we report on a novel interaction between the E3 ligase BRAP (also referred to as IMP), a negative regulator of the MAPK scaffold protein KSR, and two closely related deubiquitylases, USP15 and USP4. USP15 as well as USP4 oppose the autoubiquitylation of BRAP, whereas BRAP promotes the ubiquitylation of USP15. | SIGNOR-272029 |
Q06710 | Q9GZV5 | 2 | binding | up-regulates | 0.303 | Taz is a coactivator for pax8 and ttf-1, two transcription factors involved in thyroid differentiation. / we show that this interaction leads to a significant enhancement of the transcriptional activity of pax8 and ttf-1 on the thyroglobulin promoter thus suggesting a role of taz in the control of genes involved in thy... | SIGNOR-182253 |
P49841 | P30405 | 1 | phosphorylation | up-regulates activity | 0.378 | Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion|We conclude that CypD phosphorylation at S191 residue leads to its binding to OSCP and thus sensitizes mPTP opening for the subsequent cell death.|Under baseline conditio... | SIGNOR-264880 |
P45973 | Q7Z3K3 | 2 | binding | down-regulates activity | 0.433 | POGZ was found to bind to HP1alpha through a zinc-finger-like motif. Binding by POGZ, mediated through its zinc-finger-like motif, competed with PxVxL proteins and destabilized the HP1alpha-chromatin interaction. | SIGNOR-264487 |
Q9UQL6 | Q14814 | 2 | binding | down-regulates | 0.71 | The histone deacetylase hdac-5, upon dephosphorylation and translocation to the nucleus, directly inactivates mef2, preventing myogenesis. | SIGNOR-84029 |
P22415 | P49715 | 2 | binding | up-regulates activity | 0.317 | Our studies show that the human C/EBPa protein stimulates USF to bind to a USF consensus element within C/EBPa promoter and activates it by two- to threefold.The mechanism by which C/EBPa enhances USF binding and transactivation is currently under study. | SIGNOR-255701 |
P51397 | P42345 | 0 | phosphorylation | down-regulates activity | 0.395 | A critical step in autophagy induction comprises the inactivation of a key negative regulator of the process, the Ser/Thr kinase mammalian target of rapamycin (mTOR). Here we identify death-associated protein 1 (DAP1) as a novel substrate of mTOR that negatively regulates autophagy. Mapping of the phosphorylation sites... | SIGNOR-259812 |
Q96SN8 | O43379 | 1 | relocalization | up-regulates activity | 0.545 | Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at seq... | SIGNOR-271723 |
P49715 | P84022 | 2 | binding | down-regulates activity | 0.375 | Thus, repression of the activity of C/EBPs by Smad3/4 at C/EBP binding sites inhibited transcription from the PPAR2 and leptin promoters | SIGNOR-241924 |
Q99704 | P05106 | 2 | binding | down-regulates activity | 0.334 | Integrins also bind to many PTBdomain-containing proteins (Calderwood et al., 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation | SIGNOR-257687 |
P08754 | O43613 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256876 |
Q9H4A3 | Q9UH77 | 2 | binding | down-regulates quantity by destabilization | 0.563 | CUL3 assembles with BTB proteins to form Cullin-RING E3 ubiquitin ligase complexes. To explore how a CUL3-KLHL3 complex might operate, we immunoprecipitated KLHL3 and found that it associated strongly with WNK isoforms and CUL3. These results suggest that the CUL3-KLHL3 E3 ligase complex regulates blood pressure via it... | SIGNOR-272099 |
O15297 | P51812 | 1 | dephosphorylation | down-regulates activity | 0.361 | RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the pres... | SIGNOR-248322 |
O43150 | P84077 | 1 | gtpase-activating protein | up-regulates activity | 0.655 | Pap is a multidomain protein composed of an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal SH3 domain. In addition, in vitro recombinant Pap exhibits strong GTPase-activating prot... | SIGNOR-269705 |
P50148 | P25103 | 2 | binding | up-regulates activity | 0.499 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257374 |
P49736 | O00311 | 0 | phosphorylation | up-regulates | 0.962 | In this work, by in vitro kinase reactions and mass spectrometry analysis of the products, we have mapped phosphorylation sites in the n terminus of mcm2 by cdc7, cdk2, cdk1, and ck2 | SIGNOR-143984 |
O14641 | O15169 | 2 | binding | up-regulates activity | 0.669 | Dishevelled (dvl) transduces the wnt signal by interacting with the cytoplasmic axin complex. | SIGNOR-155221 |
P45983 | O95644 | 1 | phosphorylation | down-regulates activity | 0.621 | It has been previously shown that NF-ATc1 accumulates in the nucleus of activated CD4 + T cells from Jnk1 \n \u2212/\u2212 mice 35\u2022 and that JNK1 phosphorylates and inactivates NFATc1 in Jurkat T cells 47 , indicating that JNK1 is an inhibitor of NFAT. | SIGNOR-280031 |
P84022 | P12755 | 2 | binding | down-regulates activity | 0.728 | Smad2/3 interacts with c-ski through its c-terminal mh2 domain in a tgf-beta-dependent mannerc-ski is incorporated in the smad dna binding complex, interferes with the interaction of smad3 with a transcriptional co-activator, p300, and in turn recruits hdac. c-ski is thus a transcriptional co-repressor that links smads... | SIGNOR-232123 |
P12931 | Q9Y3Q4 | 1 | phosphorylation | up-regulates | 0.371 | These results demonstrate that src tyrosine kinase enhances hcn4 currents by shifting their activation to more positive potentials and increasing the whole cell channel conductance as well as speeding the channel kinetics. The tyrosine residue that mediates most of src s actions on hcn4 channels is tyr531. | SIGNOR-158707 |
O60260 | Q16665 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | These results indicate that Parkin inhibits HIF-1alpha transcriptional activity.|Ubiquitination of HIF-1alpha at lysine 477 by Parkin. | SIGNOR-278542 |
P45983 | P14778 | 0 | phosphorylation | up-regulates activity | 0.379 | Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab | SIGNOR-249513 |
Q13618 | Q9H2C0 | 2 | binding | up-regulates activity | 0.672 | Gigaxonin is the substrate-specific adaptor for a new Cul3-E3-ubiquitin ligase family that promotes the proteasome dependent degradation of its partners MAP1B, MAP8 and tubulin cofactor B. | SIGNOR-268944 |
P00533 | P37231 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.513 | Here, we found that nuclear EGFR induced phosphorylation of PPARγ at Tyr-74 leading to PPARγ ubiquitination and degradation by mouse double minute 2 (MDM2) ubiquitin ligase. | SIGNOR-277190 |
P19174 | Q92830 | 0 | acetylation | down-regulates activity | 0.2 | The histone acetyltransferase GCN5 (general control non-repressed protein 5) acetylates PGC-1alpha and suppresses its transcriptional activity, whereas sirtuin 1 deacetylates and activates PGC-1alpha. | SIGNOR-275498 |
P01106 | Q13485 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.64 | Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-β (TGF-β) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-mycpromoter. | SIGNOR-251493 |
Q9Y4K3 | Q53ET0 | 1 | ubiquitination | down-regulates quantity | 0.307 | Consistently, TRAF6 reduced G6pase gene expression or reporter activity induced by wild-type CRTC1 and CRTC2 but not TRAF6-interaction-defective CRTC1 and CRTC2 (XREF_FIG and XREF_SUPPLEMENTARY).|Indeed, TRAF6, the E3 ubiquitin ligase activated by IL-1beta associates with and ubiquitinates CRTC2. | SIGNOR-278725 |
Q6MZQ0 | Q8WZ73 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.261 | RFFL is an E3 ligase for PRR5L. | SIGNOR-271495 |
Q6GPH6 | Q14643 | 2 | binding | up-regulates | 0.2 | Recruitment of g protein also can activate phospholipase c (plc) that in turn increases inositol triphosphate (ip3) levels and induces ca2+ release from internal stores. | SIGNOR-172497 |
P24844 | P17252 | 0 | phosphorylation | down-regulates | 0.278 | Rlc can also be phosphorylated at ser1/ser2/thr9 by protein kinase c (pkc). Biophysical studies show that phosphorylation at these sites leads to an increase in the km of myosin light chain kinase (mlck) for rlc, thereby indirectly inhibiting myosin ii activity | SIGNOR-192792 |
P50553 | Q86Y01 | 2 | binding | down-regulates | 0.261 | Through its binding to p300, dtx1 inhibited transcriptional activation by the neural-specific helix-loop-helix-type transcription factor mash1 | SIGNOR-110626 |
P40763 | P22455 | 0 | phosphorylation | up-regulates activity | 0.402 | Activation of Stat1 and Stat3 by FGFR derivatives. Lysates of 293T cells transfected as indicated were analysed by Western blotting using Phospho-Stat1 (Y701) antisera (top) or Stat1 antisera (bottom). (b) The same lysates in (a) were re-examined for phosphorylated Stat3 by Western blotting with Phospho-Stat3 (Y705) (t... | SIGNOR-251142 |
P30305 | O14757 | 0 | phosphorylation | down-regulates activity | 0.785 | Here, we show that cdc25b is phosphorylated by chk1 in vitro on multiple residues, including s230 and s563.We show that the s230-phosphorylated form of cdc25b is located at the centrosome from early s phase until mitosis. Furthermore, mutation of s230 to alanine increases the mitotic-inducing activity of cdc25b | SIGNOR-149898 |
Q16623 | Q86UW7 | 2 | binding | up-regulates activity | 0.357 | CAPS interacted independently with either syntaxin-1 or SNAP-25 suggesting that CAPS might promote QaQbc-SNARE heterodimer formation. CAPS binding to syntaxin-1 was mediated by the membrane-proximal C-terminal SNARE motif (H3) and membrane linker domain sequences of syntaxin-1 | SIGNOR-264337 |
P01008 | P03951 | 1 | cleavage | down-regulates activity | 0.657 | Antithrombin (AT), a member of the serine protease inhibitor (SERPIN) superfamily, is a major circulating inhibitor of blood coagulation proteases such as factor (F) IIa (known as thrombin), FXa and, to a lesser extent, FIXa, FXIa and FXIIa. SERPINC1, which encodes AT in humans, is located on chromosome 1q25.1 | SIGNOR-264137 |
Q16512 | P00533 | 1 | phosphorylation | down-regulates activity | 0.2 | This identified thr654 in egfr as the pkn1 phosphorylation siteit has been shown that the phosphorylation of egfr at thr654 by pkc reduces the tyrosine kinase activity of the receptor | SIGNOR-174755 |
P47871 | P01275 | 2 | binding | up-regulates | 0.777 | In contrast, stimulation of gs-coupled receptors by glucagon or epinephrine activates lats1/2 kinase activity, thereby inhibiting yap function. | SIGNOR-198504 |
P12931 | P41235 | 1 | phosphorylation | down-regulates | 0.365 | Here we show that c-src phosphorylates human hnf4_ on three tyrosines phosphomimetic mutants in the lbd decrease p1-hnf4_ protein stability, nuclear localization and transactivation function. | SIGNOR-195896 |
Q9H2K2 | Q92530 | 1 | ADP-ribosylation | down-regulates quantity by destabilization | 0.496 | We identify the ADP-ribosyltransferase tankyrase (TNKS) and the 19S assembly chaperones dp27 and dS5b as direct binding partners of the proteasome regulator PI31. TNKS-mediated ADP-ribosylation of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression by PI31. | SIGNOR-263386 |
Q14493 | P0DPK5 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265416 |
P11473 | P68400 | 0 | phosphorylation | up-regulates | 0.336 | Casein kinase ii (ckii) phosphorylates vdr both in vitro and in vivo at serine 208 within the hinge domain. This phosphorylation does not affect the ability of vdr to bind dna, but increases its ability to transactivate target promoters | SIGNOR-153711 |
O14757 | P62714 | 0 | dephosphorylation | down-regulates activity | 0.266 | Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit|In response to genotoxic stress, Chk1 is phosphorylated on serines 317 (S317) and 345 (S345) by the ataxia-telangiectasia-related (ATR) protein kinase. Phosphorylation of Chk1 on these C-terminal serine residues is used as ... | SIGNOR-248578 |
P51668 | O00623 | 2 | binding | up-regulates activity | 0.626 | Here we report on the identification of the protein-ubiquitin ligases that are responsible for the ubiquitination of the peroxisomal protein import receptor Pex5. It is demonstrated that each of the three RING peroxins Pex2, Pex10, and Pex12 exhibits ubiquitin-protein isopeptide ligase activity. Our results show that P... | SIGNOR-253024 |
Q08345 | Q96P44 | 2 | binding | up-regulates activity | 0.2 | The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor tyrosine kinases that signal in response to collagen.|Consistent with this view128, we showed that ectopic expression of DDR1b or DDR2 in HT1080 cells elicited a potent growth inhibitory effect only when the cells were cultured on 2D or 3D COL1 m... | SIGNOR-272341 |
Q07889 | P29353 | 2 | binding | up-regulates | 0.77 | TGF-beta-induced ShcA phosphorylation induces ShcA association with Grb2 and Sos, thereby initiating the well-characterised pathway linking receptor tyrosine kinases with Erk MAP kinases. | SIGNOR-236363 |
Q9BXL7 | Q92918 | 0 | phosphorylation | up-regulates activity | 0.493 | HPK1 interacts with CARMA1 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARMA1. Interestingly, the putative HPK1 phosphorylation sites in CARMA1 are different from known PKC consensus sites. Mutations of residues S549, S551, and S552 in CARMA1 abrogated phosphorylation of a CARMA1-linke... | SIGNOR-276259 |
Q9Y6H5 | Q9NV58 | 0 | ubiquitination | up-regulates quantity | 0.453 | Ubiquitylation of synphilin-1 by Dorfin. A, synphilin-1 is ubiquitylated in HEK293 cells. Several lines of evidence have suggested that derangements in the ubiquitin-proteasome protein degradation pathway may have a prominent role in the pathogenesis of PD (5). Our present study shows that Dorfin, an E3 ubiquityl ligas... | SIGNOR-271455 |
Q92837 | P49841 | 2 | binding | up-regulates | 0.776 | The frat family consists of three members: frat-1, -2, and -3. It has been shown that different sites of frat-1 interact with gsk-3 and dvl-1 and that wnt-1 disintegrates the complex formation of frat-1, dvl-1, and axin, resulting in the activation of the wnt signaling pathway | SIGNOR-58219 |
Q13309 | Q9H211 | 2 | binding | down-regulates quantity by destabilization | 0.659 | Biochemical studies showed that Skp2 interacts specifically with cyclin E and thereby promotes its ubiquitylation and degradation both in vivo and in vitro. These results suggest that specific degradation of cyclin E and p27(Kip1) is mediated by the SCF(Skp2) ubiquitin ligase complex, and that Skp2 may control chromos... | SIGNOR-272565 |
P51790 | Q9UQM7 | 0 | phosphorylation | up-regulates activity | 0.337 | Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current|The N-terminus of CLC-3, which contains a CaMKII consensus sequence, was phosphorylated by CaMKII in vitro, and mutation of the serine at position 109 (S109A) ... | SIGNOR-275863 |
P98170 | O15392 | 2 | binding | up-regulates | 0.494 | Formation of a survivin-xiap complex promotes increased xiap stability against ubiquitination/proteasomal destruction and synergistic apoptosis | SIGNOR-126367 |
P60709 | Q9Y4I1 | 2 | binding | up-regulates activity | 0.409 | Myosin Va regulates exocytosis of large dense-core vesicles (LDCVs). interestingly, inhibition of myosin Va potentiates LDCV exocytosis to the same extent as F-actin depolymerization does, suggesting that myosin Va cooperates with the actin cytoskeleton to impede or control LDCV exocytosis | SIGNOR-269280 |
P27816 | P06493 | 0 | phosphorylation | down-regulates activity | 0.497 | We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region. Mutation of Ser787 to Glu strikingly reduced the MAP4's MT-poly... | SIGNOR-277459 |
P04637 | Q9NS56 | 0 | ubiquitination | down-regulates | 0.461 | Plk1-mediated phosphorylation of topors regulates p53 stabilityherein, we have identified topoisomerase i-binding protein (topors), a p53-binding protein, as a plk1 target. We show that plk1 phosphorylates topors on ser(718) in vivo. Significantly, expression of a plk1-unphosphorylatable topors mutant (s718a) leads to ... | SIGNOR-185848 |
P29353 | P08069 | 2 | binding | up-regulates activity | 0.736 | In our present work, we show that both IRS-1 and SHC interact directly with the juxtamembrane region of the IGFIR in a phosphotyrosine-dependent manner. |We propose a model in which IGFIR autophosphorylation of Tyr-950 forms a direct binding site for the amino-terminal receptor binding domains of SHC and IRS-1. This in... | SIGNOR-262587 |
P12931 | P61586 | 1 | phosphorylation | down-regulates activity | 0.668 | When these RhoA mutants were coexpressed with Bcr-Abl, phosphorylation levels of Y34F and Y66F RhoA mutants dramatically decreased to 32% and 17%, respectively. As expected, when Y34 and Y66 were both mutated to phenylalanine, phosphorylation was completely abolished. Together, these observations indicate that Y34 and ... | SIGNOR-271701 |
Q9UEW8 | Q04759 | 0 | phosphorylation | up-regulates activity | 0.487 | Recombinant SPAK was phosphorylated on Ser-311 in its kinase domain by PKCtheta, but not by PKCalpha. This synergistic activity, as well as the receptor-induced SPAK activation, required the PKCtheta-interacting region of SPAK, and Ser-311 mutation greatly reduced these activities of SPAK. | SIGNOR-276007 |
O75676 | P68400 | 0 | phosphorylation | up-regulates activity | 0.281 | Here we report that the CK2 protein kinase, which contributes to NF-kappaB activation following UV radiation in a p38-dependent manner, physically interacts with MSK2 but not MSK1 and that CK2 inhibition specifically impairs UV-induced MSK2 kinase activation. A putative site of CK2 phosphorylation was mapped to MSK2 re... | SIGNOR-276268 |
Q13315 | O75150 | 1 | phosphorylation | up-regulates | 0.443 | E3 ubiquitin ligase, a heterodimeric complex of the ringfinger rfn20/rfn40 is phosphorylated by atm. | SIGNOR-175003 |
P60484 | Q93009 | 0 | deubiquitination | down-regulates activity | 0.741 | BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP|hese data indicate that BCR-ABL phosphorylation of HAUSP modulates HAUSP’s deubiquitinase activity toward PTEN. | SIGNOR-276533 |
Q9NZJ0 | Q13569 | 2 | binding | down-regulates quantity by destabilization | 0.358 | TDG Is Polyubiquitinated by CRL4Cdt2 E3 Ubiquitin Ligase in a PIP Degron-dependent Manner | SIGNOR-272847 |
Q9H2K2 | O15169 | 1 | ADP-ribosylation | down-regulates quantity by destabilization | 0.705 | Together, these findings are consistent with the hypothesis that TNKS promotes the ubiquitination and degradation of axin, which may be mediated, at least in part, through the direct PARsylation of axin. | SIGNOR-263378 |
O00548 | Q9UM47 | 2 | binding | up-regulates | 0.63 | These results suggest that delta1, jagged1, and jagged2 are ligands for notch1 and notch3 receptors. | SIGNOR-82398 |
Q13322 | P12931 | 0 | phosphorylation | down-regulates | 0.447 | Grb10 tyrosine phosphorylation was stimulated by expression of constitutively active src or fyn in cells and by incubation with purified src or fyn in vitro. The insulin stimulated or src/fyn-mediated tyrosine phosphorylation in vivo was significantly reduced when grb10 tyrosine 67 was changed to glycine. This mutant f... | SIGNOR-78706 |
Q9UBF6 | P25963 | 1 | ubiquitination | down-regulates activity | 0.2 | SAG (Sensitive to Apoptosis Gene), also known as RBX2 (RING box protein 2), ROC2 (Regulator of Cullins 2), or RNF7 (RING Finger Protein 7), was originally cloned in our laboratory as a redox inducible antioxidant protein and later characterized as the second member of the RBX/ROC RING component of the SCF (SKP1-CUL-F-b... | SIGNOR-271451 |
P30968 | P08754 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257177 |
P60953 | P63096 | 2 | binding | up-regulates activity | 0.523 | These findings indicate that both G alpha(i) and G beta gamma stimulate Rac and Cdc42 pathways with lysophosphatidic acid-induced cell spreading on fibronectin | SIGNOR-256531 |
Q9NR19 | O15297 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | As expected, we found that glucose deprivation induced the binding of TFEB (Figure S4C) and ACSS2 (Figure S4D) to the promoter regions of MAP1LC3B, ATG3, and WIPI-1 as well as mRNA (Figure 3H) and protein (Figure 3I) expression of these genes; | SIGNOR-276560 |
P15172 | P11802 | 2 | binding | down-regulates | 0.511 | In contrast to cdk2, cyclin d/cdk4 blocks myod activity through an as yet unclear mechanism that may involve direct binding. Cyclin d/cdk4 can also block the activity of myogenin and all mef2 isoforms. | SIGNOR-176527 |
P06493 | Q14807 | 1 | phosphorylation | up-regulates activity | 0.344 | Cdc2-mediated phosphorylation of kid controls its distribution to spindle and chromosomes. We identify ser427 and thr463 as m phase-specific phosphorylation sites and cdc2-cyclin b as a thr463 kinase. Kid with a thr463 to alanine mutation fails to be localized on chromosomes and is only detected along spindles, althoug... | SIGNOR-100964 |
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