IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O14757 | Q06609 | 1 | phosphorylation | up-regulates | 0.843 | We demonstrate that chk1 interacts with rad51, and that rad51 is phosphorylated on thr 309 in a chk1-dependent manner | SIGNOR-133375 |
P05412 | Q8TD08 | 0 | phosphorylation | up-regulates | 0.428 | Up-regulation of c-jun mrna in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-jun n-terminal kinases are required for efficient up-regulation of c-jun protein. these data suggest that erks, rather than jnks, are required for c- jun up-regulation. | SIGNOR-91375 |
Q16539 | O43257 | 1 | phosphorylation | up-regulates | 0.314 | We show that the srcap subunit named znhit1 or p18(hamlet), which is a substrate of p38 mapk, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 mapk-dependent manner. Furthermore, p18hamlet was phosphorylated during myoblast differentiation in a p38 mapk-dependent manner (dal testo ... | SIGNOR-165571 |
Q16611 | P10415 | 2 | binding | down-regulates | 0.677 | Bcl-2 bind to bax or five other pro-apoptotic relatives (bak, bad, bik, bid or bim) | SIGNOR-55546 |
P63000 | Q96P48 | 0 | gtpase-activating protein | down-regulates activity | 0.455 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260451 |
P24394 | P23458 | 2 | binding | up-regulates | 0.716 | IL-4Rα, γc, and IL-13Rα1 all contain proline-rich box-1 regions that bind jak1, jak3, and tyk2, respectively. Il-4 uses the type ii receptor, and IL-13R1 Binds tyk2. Il-13 results in activation of jak1 and tyk2 in hematopoietic and nonhematopoietic cells. | SIGNOR-100774 |
P41240 | P13639 | 1 | phosphorylation | down-regulates quantity | 0.264 | C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2.|In this report, we show that eukaryotic elongation factor 2 (eEF2) is a new protein substrate of Csk and could locate in the nucleus. | SIGNOR-279698 |
P08631 | P19174 | 1 | phosphorylation | up-regulates activity | 0.681 | The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated ... | SIGNOR-249361 |
O14733 | Q9NYL2 | 0 | phosphorylation | up-regulates activity | 0.2 | We show here that members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and MKK4 and -7 in death signaling. | SIGNOR-243345 |
Q13489 | Q9Y572 | 1 | polyubiquitination | up-regulates activity | 0.647 | CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. | SIGNOR-272714 |
Q8WU20 | P22681 | 0 | ubiquitination | down-regulates | 0.576 | The experiments presented in this report illustrate that in response to fgf stimulation, cbl is recruited by grb2 binding to the frs2_ multiprotein complex, resulting in ubiquitination of frs2_ and fgfr. grb2 functions as a link between frs2_ and cbl;grb2 is bound to tyrosine-phosphorylated frs2_ by means of its sh2 d... | SIGNOR-87166 |
Q3KR16 | P53350 | 0 | phosphorylation | up-regulates | 0.415 | We reported previously that a guanine nucleotide exchange factor, myogef, localizes to the central spindle, activates rhoa, and is required for cytokinesis. In this study, we have found that plk1 (polo-like kinase 1) can phosphorylate myogef, thereby recruiting myogef to the central spindle as well as enhancing myogef ... | SIGNOR-179954 |
P24941 | P54198 | 1 | phosphorylation | up-regulates activity | 0.326 | Hira bound to and was phosphorylated by cyclin a- and e-cdk2 in vitrohira became phosphorylated on threonine 555 in s phase when cyclin-cdk2 kinases are active.ectopic expression of hira in cells caused arrest in s phase and this is consistent with the notion that it is a cyclin-cdk2 substrate that has a role in contro... | SIGNOR-105548 |
Q9Y5H9 | Q9Y5G4 | 2 | binding | up-regulates activity | 0.2 | The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. Pcdh-alpha proteins interact with beta1-integrin to promote cell adhesion. They also form oligomers with Pcdh-gamma proteins at the same membrane sites. | SIGNOR-265678 |
Q9Y5P4 | P78368 | 0 | phosphorylation | down-regulates | 0.2 | These results indicate that ckigamma2 hyperphosphorylates the serine-repeat motif of cert, thereby inactivating cert and down-regulating the synthesis of sphingomyelin. | SIGNOR-182160 |
P45983 | P17275 | 1 | phosphorylation | up-regulates activity | 0.719 | JunB-control of IL-4 expression is mediated by the phosphorylation of JunB at Thr102 and -104 by JNK MAP kinase. The synergy between c-Maf and JunB can be attributed to cooperative DNA binding, which is facilitated by JunB phosphorylation. | SIGNOR-250120 |
Q9UNH7 | P08069 | 2 | binding | down-regulates quantity | 0.2 | Here, we discovered that the binding between SNX-BARs and CI-MPR or IGF1R is mediated by the phox-homology (PX) domain of SNX5 or SNX6 and a bipartite motif, termed SNX-BAR-binding motif (SBM), in the cargoes. our studies establish that SNX-BARs function as a direct cargo-selecting module for a large set of transmembra... | SIGNOR-269445 |
Q6R327 | P49840 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.387 | We show that this process is dependent on glycogen synthase kinase 3 (GSK3): GSK3 was associated with rictor and directly phosphorylated the Thr-1695 site in a putative CDC4 phospho-degron motif of rictor; mutation of this site impaired the interaction between rictor and FBXW7, decreased rictor ubiquitination, and incr... | SIGNOR-276899 |
Q86TM6 | P60604 | 0 | ubiquitination | up-regulates activity | 0.659 | We show that human HRD1 is a non-glycosylated, stable ER protein with a cytosolic RING-H2 finger domain. In the presence of the ubiquitin-conjugating enzyme UBC7, the RING-H2 finger has in vitro ubiquitination activity for Lys(48)-specific polyubiquitin linkage, suggesting that human HRD1 is an E3 ubiquitin ligase invo... | SIGNOR-272593 |
P68400 | P52655 | 1 | phosphorylation | up-regulates activity | 0.379 | We now show that human TFIIA is phosphorylated in vivo on serine residues that are partially conserved between yeast and human TFIIA large subunits. Alanine substitution mutation of serine residues 316 and 321 in TFIIA alphabeta reduced TFIIA phosphorylation significantly in vivo. Additional alanine substitutions at se... | SIGNOR-250877 |
Q13322 | P27361 | 0 | phosphorylation | up-regulates | 0.298 | Phosphorylation of grb10 by mitogen-activated protein kinase: identification of ser150 and ser476 of human grb10zeta as major phosphorylation sitesreplacing ser(150) and ser(476) with alanines reduced the inhibitory effect of human grb10zeta on insulin-stimulated irs1 tyrosine phosphorylation | SIGNOR-138171 |
Q12800 | Q00526 | 0 | phosphorylation | down-regulates | 0.264 | In vitro, lsf is phosphorylated by cyclin e/cyclin-dependent kinase 2 (cdk2), cyclin c/cdk2, and cyclin c/cdk3, predominantly on s309. Phosphorylation by cyclin c/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of lsf during g1 progression | SIGNOR-184164 |
O94806 | O96013 | 1 | phosphorylation | up-regulates activity | 0.252 | PAK4 activity is regulated by an autoinhibitory domain that is released upon RhoGTPase binding as well as phosphorylation at Ser474 in the activation loop of the kinase domain. In the present study, we add another level of complexity to PAK4 regulation by showing that phosphorylation at Ser99 is required for its target... | SIGNOR-275931 |
P00533 | P00533 | 2 | phosphorylation | up-regulates activity | 0.2 | EGFR possesses three major and two minor tyrosine autophosphorylation sites located at Y1068, Y1148, Y1173, and at Y992 and Y1086 respectively. In addition, EGFR Y1114 is preceded by glutamic acid (Figure 1), which should be preferred by the EGFR kinase as indicated in previous work | SIGNOR-236527 |
Q14192 | P10275 | 2 | binding | up-regulates | 0.522 | Fhl2 contains a strong, autonomous transactivation function and binds specifically to the ar in vitro and in vivo. | SIGNOR-74703 |
P19419 | Q99102 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Through promoter screening, overexpressing methods and luciferase reporter studies, we found that transcription factors CREB, Ets-1, Elk-1 and STAT1 can positively regulate MUC4 expression at the promoter and mRNA level. | SIGNOR-254096 |
Q13554 | P49840 | 1 | phosphorylation | down-regulates | 0.291 | Inhibitory phosphorylation of gsk-3 by camkii couples depolarization to neuronal survival. | SIGNOR-167962 |
P46531 | O00548 | 2 | binding | up-regulates activity | 0.627 | Notch signaling is a highly conserved pathway involved in cell fate choice during development with Delta and Jagged constituting the two evolutionary conserved families of Notch ligands. These ligands are transmembrane proteins with conserved biochemical structure that share their receptors and signal through a common ... | SIGNOR-209732 |
Q8N122 | Q9UBE8 | 0 | phosphorylation | down-regulates activity | 0.327 | NLK inhibits mTORC1 lysosomal localization and thereby suppresses mTORC1 activation. Mechanistically, NLK phosphorylates Raptor on S863 to disrupt its interaction with the Rag GTPase, which is important for mTORC1 lysosomal recruitment. | SIGNOR-273908 |
P10145 | P25025 | 2 | binding | up-regulates | 0.86 | Il-8 activates both the cxcr1 and the cxcr2 on microvascular endothelial cells, using different signal transduction cascades. | SIGNOR-107983 |
Q12851 | Q9UQF2 | 2 | binding | down-regulates | 0.2 | DLK mutants were used to demonstrate that a DLK leucine zipper-leucine zipper interaction is necessary for DLK dimerization and to show that DLK dimerization mediated by the leucine zipper domain is prerequisite for DLK activity and subsequent activation of stress-activated protein kinase (SAPK). | SIGNOR-75385 |
Q9UPW6 | Q9C0K0 | 1 | transcriptional regulation | down-regulates quantity | 0.495 | Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the ... | SIGNOR-268931 |
Q9NS23 | O14965 | 0 | phosphorylation | down-regulates | 0.448 | Aurora-a appears to phosphorylate rassf1a at threonine202 and/or serine203 that reside within the known microtubule-binding domain of rassf1a. Substitutions of these residues with glutamic acid at both positions, mimicking constitutive phosphorylation of rassf1a, disrupt rassf1a interactions with microtubules and aboli... | SIGNOR-155815 |
Q13547 | Q99801 | 2 | binding | down-regulates activity | 0.369 | NKX3.1 also binds HDAC1 and releases p53 from p53-MDM2-HDAC1 complex, promoting p53 acetylation and activity. | SIGNOR-251549 |
P12931 | P42229 | 1 | phosphorylation | up-regulates | 0.75 | Src can thus directly tyrosine-phosphorylate the activation site of stat5 (tyr 694 in stat5a), and src may contribute to epo-induced signal transduction via stat5. | SIGNOR-111078 |
Q9UQM7 | O14490 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.397 | CaMKIIα activated by the NMDA receptor phosphorylates GKAP Ser54 to induce polyubiquitination of GKAP. | SIGNOR-276429 |
P06493 | Q9UKX7 | 1 | phosphorylation | down-regulates | 0.421 | These results suggest that both ERK and Cdk1 directly phosphorylate Nup50 at Ser221 in intact cells|Notably, erk phosphorylation of the fg repeat region of nup50 reduced its affinity for importin-beta family proteins, importin-beta and transportin. | SIGNOR-188061 |
Q9NQS5 | P63096 | 2 | binding | up-regulates activity | 0.284 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256704 |
P06241 | P08575 | 0 | dephosphorylation | up-regulates activity | 0.73 | On the membrane SKAP55, via its phosphorylated Tyr-271, further binds the SH2 domain of Fyn to replace the low-affinity bound inhibitory site of the kinase. Consequently, CD45 may have transiently disassociated with the Tyr-232 residue of SKAP55 through dephosphorylation and simultaneously interacted with the released ... | SIGNOR-248352 |
P28562 | Q16539 | 2 | dephosphorylation | down-regulates activity | 0.805 | The activity of MAPKs can be also regulated by a family of DUSPs (dual-specificity phosphatases)/MKPs (MAPK phosphatases), which dephosphorylate both phosphotyrosine and phosphothreonine residues MKPs 1, 4, 5 and 7 can dephosphorylate p38_ and p38_ in addition to JNK MAPKs. Importantly, some MKPs are transcriptionally ... | SIGNOR-166571 |
P17612 | P54296 | 1 | phosphorylation | down-regulates | 0.2 | This binding is regulated in vitro by phosphorylation of a single serine residue (ser76) in the immediately adjacent amino-terminal domain mp1. M-protein phosphorylation by camp-dependent kinase a inhibits binding to myosin lmm. | SIGNOR-56395 |
P24941 | P06401 | 1 | phosphorylation | down-regulates | 0.441 | Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26s proteasome | SIGNOR-74708 |
P78352 | Q9P1A6 | 2 | binding | up-regulates activity | 0.705 | SAPAPs are specifically expressed in neuronal cells and enriched in the PSD fraction. SAPAPs induce the enrichment of PSD-95/SAP90 to the plasma membrane in transfected cells. Thus, SAPAPs may have a potential activity to maintain the structure of PSD by concentrating its components to the membrane area. | SIGNOR-264210 |
P11274 | Q8TBB1 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.267 | We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous su... | SIGNOR-272903 |
Q14814 | Q9UKX2 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.327 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238712 |
P63092 | Q01726 | 2 | binding | up-regulates activity | 0.481 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268697 |
Q9Y6D9 | O43683 | 0 | relocalization | up-regulates activity | 0.727 | Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity | SIGNOR-252017 |
P18846 | P18146 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.275 | Phosphorylated CREB and ATF1 then bind to the CRE of the egr-1 promoter and cause a stress-dependent transcriptional activation of this gene. | SIGNOR-271686 |
P36956 | P27361 | 0 | phosphorylation | up-regulates activity | 0.443 | Map kinases erk1/2 phosphorylate sterol regulatory element-binding protein (srebp)-1a at serine 117 in vitro. mutation of serine 117 to alanine abolished erk2-mediated phosphorylation in vitro and the map kinase-related transcriptional activation of srebp-1a by insulin and platelet-derived growth factor in vivo. | SIGNOR-80096 |
Q05513 | Q9GZQ8 | 1 | phosphorylation | down-regulates activity | 0.2 | LC3B is phosphorylated at Thr-50 within the LDS by serine/threonine kinase (STK) 3 and STK4. Here, we identified LIR motifs in STK3 and atypical protein kinase Cζ (PKCζ) and never in mitosis A (NIMA)-related kinase 9 (NEK9). All three kinases phosphorylated LC3B Thr-50 in vitro A phospho-mimicking substitution of Thr-5... | SIGNOR-273906 |
P04637 | P48730 | 0 | phosphorylation | up-regulates | 0.578 | Here we show that the direct association between a p53 n-terminal peptide and mdm2 is disrupted by phosphorylation of the peptide on thr(18) but not by phosphorylation at other n-terminal sites, including ser(15) and ser(37). Thr(18) was phosphorylated in vitro by casein kinase (ck1). | SIGNOR-75889 |
Q5T3J3 | Q96T88 | 0 | ubiquitination | down-regulates activity | 0.2 | In our study, we found the UHRF1 is sufficient to suppress RIF1 accumulation at DSBs in S phase and CtIP functions as a negative regulator of RIF1 only in G2 phase (XREF_FIG; XREF_SUPPLEMENTARY).|UHRF1 ubiquitinates RIF1. | SIGNOR-278604 |
Q9Y5X2 | O14920 | 2 | binding | up-regulates activity | 0.2 | IFNγ induced JAK1-mediated phosphorylation of SNX8 at Tyr95 and Tyr126, which promoted the recruitment of IKKβ to the JAK1 complex. | SIGNOR-273646 |
Q9NYJ8 | Q13546 | 2 | binding | up-regulates activity | 0.864 | TNF_ induced the polyubiquitination of RIP and the association of polyubiquitinated RIP with TAB2. | SIGNOR-128406 |
P17542 | P25800 | 2 | binding | up-regulates | 0.736 | Transcriptional activity of tal1 in t cell acute lymphoblastic leukemia (t-all) requires rbtn1 or -2 | SIGNOR-46114 |
O95644 | Q13627 | 0 | phosphorylation | up-regulates activity | 0.429 | DYRK1A phosphorylation of NFATc1 and alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.|Here, we demonstrated that DYRK1A increased NFATc1 (NFATc1 and alphaA isoform) protein stability, in contrast to the decrease of NFATc2 protein stability by DYRK1A. | SIGNOR-278278 |
Q99835 | P08754 | 2 | binding | up-regulates | 0.429 | Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. | SIGNOR-199165 |
Q13153 | P17600 | 1 | phosphorylation | up-regulates activity | 0.349 | Synapsin I is phosphorylated at Ser603 by p21-activated kinases. the Ser603 residue must be one of the pivotal sites for the release | SIGNOR-250235 |
P01116 | Q8N431 | 2 | binding | up-regulates | 0.2 | Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras. | SIGNOR-161508 |
O95837 | P41146 | 2 | binding | up-regulates activity | 0.353 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257209 |
P22415 | P78347 | 2 | binding | up-regulates activity | 0.489 | TFII-I has been shown to interact with USF and to associate with either E-box elements or initiator sequences to activate gene transcription | SIGNOR-268538 |
P51955 | Q8N137 | 1 | phosphorylation | down-regulates activity | 0.35 | The opposite outcomes in NEK2- and centrobin-depleted cells suggest that NEK2 antagonizes biological functions of centrobin.|These results suggest that NEK2 phosphorylates specific sites of centrobin, which are distinct from the PLK1 phosphorylation sites. | SIGNOR-279545 |
P17861 | P60900 | 2 | binding | down-regulates quantity by destabilization | 0.303 | We saw preferential binding of XBP-1u to subunits _5, _6 and _7.2. We demonstrate that XBP-1u undergoes efficient degradation in vitro by 20S proteasomes in the absence of ubiquitination. | SIGNOR-239039 |
P25445 | Q99683 | 2 | binding | up-regulates | 0.694 | Ask1 binds fas | SIGNOR-109676 |
P78509 | O15409 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.365 | By interacting with CASK, TBR1 regulates several ASD candidate genes, such as GRIN2B, AUTS2 and RELN—all of which are recurrently mutated in ASD. In areas of the brain with overlapping expression patterns, such as in glutamatergic layer 6 neurons, the TBR1–FOXP2 interaction may result in co-ordinated regulation of comm... | SIGNOR-266833 |
P29474 | P07900 | 2 | binding | up-regulates | 0.76 | The binding of hsp90 to enos enhances the activation of enos. | SIGNOR-57211 |
P04637 | Q70YC5 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.29 | Here, analysis of p53-regulated genes activated in the setting of telomere dysfunction identified Zfp365 (ZNF365 in humans) as a direct p53 target that promotes genome stability| Our study identified ZNF365 as a necessary target whose activation by p53 in the presence of critically short telomeres contributes to genomi... | SIGNOR-272476 |
Q8N5U6 | P50222 | 2 | binding | up-regulates activity | 0.375 | RFN10 co-immunoprecipitates with MEOX2. RNF10 potentiates MEOX2 transcriptional activation | SIGNOR-236968 |
Q9UK99 | Q13501 | 2 | binding | down-regulates quantity by destabilization | 0.2 | F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and targets Smurf1 for poly-ubiquitination and proteasomal degradation. The SCF complex is composed of F-box protein, Skp1... | SIGNOR-272444 |
Q15208 | O14980 | 1 | phosphorylation | up-regulates activity | 0.2 | We further uncover that STK38 modulates XPO1 export activity by phosphorylating XPO1 on serine 1055, thus regulating its own nuclear exit. | SIGNOR-277483 |
Q01105 | P48736 | 0 | phosphorylation | up-regulates activity | 0.336 | We show that PI3Kgamma phosphorylates I2PP2A on serine 9 and 93 residues resulting in enhanced interaction of I2PP2A with PP2A. | SIGNOR-278320 |
P31749 | O95988 | 2 | binding | up-regulates | 0.671 | In vivo, tcl1 forms trimers, which associate with akt. Tcl1 facilitates the oligomerization and activation of akt. Our data show that tcl1 is a novel akt kinase coactivator, which promotes akt-induced cell survival and proliferation. | SIGNOR-81713 |
Q8IZP0 | P06493 | 0 | phosphorylation | down-regulates activity | 0.419 | We identified serine 216 of Abi1 as a target of CDK1/cyclin B kinase that is phosphorylated in cells at the onset of mitosis.|Bcr-Abl-induced actin polymerization requires the Abi1 pathway, as the blockade of the signal transduction from Bcr-Abl to Abi1 abolishes the F-actin assembly|serine phosphorylation of Abi1 by C... | SIGNOR-264421 |
P16949 | P45984 | 0 | phosphorylation | down-regulates | 0.256 | Involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Here we show that in response to hyperosmotic stress, jnk phosphorylates a key cytoplasmic microtubule regulatory protein, stathmin (stmn), on conserved ser-25 an... | SIGNOR-166698 |
P17612 | O95295 | 1 | phosphorylation | up-regulates activity | 0.307 | PKA-phosphorylation of Snapin significantly increases its binding to synaptosomal-associated protein-25 (SNAP-25). Mutation of Snapin serine 50 to aspartic acid (S50D) mimics this effect of PKA phosphorylation | SIGNOR-250053 |
Q05209 | Q9Y6E0 | 0 | phosphorylation | down-regulates activity | 0.272 | In addition, MST3 can phosphorylate PTP-PEST and inhibit the tyrosine phosphatase activity of PTP-PEST.|MST3 directly phosphorylates and inactivates protein tyrosine phosphatase PTP-PEST, which enhances cell migration by enhancing the tyrosine phosphorylation of paxillin Y31 and Y118 [ ]. | SIGNOR-279127 |
P23769 | P10827 | 2 | binding | down-regulates activity | 0.2 | We found that the T3-bound TR inhibits this reporter construct driven by GATA2 alone, indicating that the target of T3-bound TR repression is GATA2. | SIGNOR-267257 |
Q92831 | Q00987 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.621 | Consistently, overexpression of MDM2 in p53 null cells caused the reduction of the protein level of PCAF, but not the mRNA level.|MDM2 ubiquitinated PCAF in vitro and in cells. | SIGNOR-278825 |
Q9HC97 | P63096 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256717 |
Q9NRY6 | Q05655 | 0 | phosphorylation | up-regulates | 0.457 | Ad198-activated pkc-delta induces phosphorylation of mitochondrial pls3 at thr21;pls3 is a critical downstream effector of pkc-delta in ad198-induced apoptosis. | SIGNOR-140759 |
P28358 | P09429 | 2 | binding | up-regulates activity | 0.292 | We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection ... | SIGNOR-240556 |
Q96J02 | Q7Z434 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.646 | These data collectively indicate that AIP4 is the E3 ligase for MAVS.|We generated single substitutions (K362A, K371A or K420A) and combined point substitutions of MAVS and tested their degradation. K371A or K420A MAVS showed partial resistance to PCBP2-induced degradation (data not shown), whereas MAVS with the combin... | SIGNOR-260362 |
P43405 | Q8N884 | 1 | phosphorylation | up-regulates activity | 0.2 | Mechanistically, viral infection or foreign DNA transfection triggers recruitment of the spleen tyrosine kinase (SYK) and cGAS to the endosomal vacuolar H+ pump (V-ATPase), where SYK is activated and then phosphorylates human cGASY214/215 (mouse cGasY200/201) to prime its activation. | SIGNOR-277844 |
Q9UQB3 | P22223 | 2 | binding | up-regulates quantity by stabilization | 0.294 | To clarify the role of p120 in mammalian cells, we have knocked down p120 with siRNA in cells expressing epithelial (E-), placental (P-), neuronal (N-), and vascular endothelial (VE-) cadherins. We report that each of these cadherins, as well as α- and β-catenins, were rapidly degraded in the absence of p120, resulting... | SIGNOR-252130 |
P32238 | P09471 | 2 | binding | up-regulates activity | 0.252 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257236 |
Q02156 | Q9H9S0 | 1 | phosphorylation | up-regulates activity | 0.329 | Taken together, our results demonstrate that PKC\u03b5-mediated phosphorylation at T200 and T280 enhances Nanog protein stability in head and neck squamous cell carcinoma.|These observations confirm that PKCepsilon modulates Nanog transcriptional activity and demonstrate that Nanog is phosphorylated by PKCepsilon at T2... | SIGNOR-278203 |
Q14938 | P54756 | 1 | transcriptional regulation | up-regulates quantity | 0.2 | For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) | SIGNOR-268909 |
Q6UWZ7 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.2 | In this study, we demonstrate that ionizing radiation (IR)-induces ATM-dependent phosphorylation of serine 404 (S404) next to the pSPxF motif. Crystal structures of BRCT/Abraxas show that phosphorylation of S404 is important for extensive interactions through the N-terminal sequence outside the pSPxF motif and leads to... | SIGNOR-255587 |
Q14344 | Q9Y2T6 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256670 |
Q01726 | P43250 | 0 | phosphorylation | down-regulates activity | 0.313 | Overexpression of GRK6 Inhibits Agonist-Induced cAMP Production in HBL Human Melanoma Cells, without Affecting MC1R Gene Expression | SIGNOR-252389 |
Q9UKB1 | Q9Y2X9 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | E3 ligase the beta-transducin repeat-containing protein 2 (beta-TrCP2) governs the ubiquitination and degradation of ZNF281. In human CRC specimens, endogenous beta-TrCP2 were inversely correlated with ZNF281. | SIGNOR-264897 |
P49768 | Q9NZ42 | 0 | cleavage | up-regulates | 0.959 | Our data reveal a direct role of pen-2 in proteolytic cleavage of ps1 and a regulatory function of aph-1, in coordination with pen-2, in the biogenesis of the ps1 complex. | SIGNOR-97113 |
Q86UR1 | A1X283 | 2 | binding | up-regulates activity | 0.347 | Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation | SIGNOR-264707 |
P17612 | P13807 | 1 | phosphorylation | down-regulates activity | 0.508 | The results presented in this paper show that the phosphorylation of glycogen synthetase a by cyclic AMP-dependent protein kinase results in the phosphorylation of two distinct serines termed site-l and site-2, which account for 90% of the total phosphorylation | SIGNOR-253009 |
Q16665 | Q9Y3V2 | 0 | sumoylation | up-regulates | 0.457 | Rsume,_a small_rwd-containing protein, enhances sumo conjugation and stabilizes hif-1alpha during hypoxia | SIGNOR-158590 |
Q04912 | P26927 | 2 | binding | up-regulates | 0.896 | P185ron is a tyrosine kinase activated by msp | SIGNOR-31107 |
P24666 | P29317 | 1 | dephosphorylation | down-regulates activity | 0.66 | The SAM domain tyrosine Y960 which has been implicated in downstream PI3K signaling is dephosphorylated exclusively by HCPTP-B. The activation loop tyrosine (Y772) which directly controls kinase activity is dephosphorylated about six times faster by HCPTP-A. In contrast, the juxtamembrane tyrosines (Y575, Y588 and Y594... | SIGNOR-246023 |
P45984 | P49768 | 1 | phosphorylation | up-regulates | 0.376 | This jnk phosphorylation of ps1 at ser(319)thr(320) enhances the stability of the ps1 c-terminal fragment that is necessary for gamma-secretase activity. | SIGNOR-179676 |
Q00535 | P35712 | 1 | phosphorylation | down-regulates quantity | 0.366 | GST-Sox6 was phosphorylated in vitro by Cdk5 and p35 (XREF_FIG).|Inhibition of Cdk5 activity by DN Cdk5 and roscovitine increases the Sox6 expression in primary cortical neurons. | SIGNOR-279365 |
P30304 | Q15208 | 0 | phosphorylation | down-regulates quantity | 0.247 | Here, we demonstrate that the depletion of serine-threonine kinase 38 (STK38) prevents the DNA-damage-induced degradation of CDC25A and subsequent G2 arrest, and that STK38 directly phosphorylates CDC25A at Ser-76, resulting in CDC25A's degradation. | SIGNOR-279488 |
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