IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q8TBJ5 | Q16650 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.486 | We found that TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2.|(3) Chromatin immunoprecipitation analysis using TBR1 antibodies showed that TBR1 bound to a conserved region in the Fezf2 gene. | SIGNOR-268967 |
Q9HC35 | Q8TDX7 | 0 | phosphorylation | up-regulates activity | 0.274 | The mitotic kinases NEK6 and NEK7 phosphorylated the EML4 N-terminal domain at Ser144 and Ser146 in vitro, and depletion of these kinases in cells led to increased EML4 binding to microtubules in mitosis. An S144A-S146A double mutant not only bound inappropriately to mitotic microtubules but also increased their stabil... | SIGNOR-273884 |
P35222 | P35712 | 2 | binding | down-regulates activity | 0.654 | SOX6 interacts with β-catenin in adipocytes, suggesting an inhibition of WNT/β-catenin signaling, thereby promoting adipogenesis. | SIGNOR-256073 |
P23634-6 | Q05397 | 0 | phosphorylation | up-regulates activity | 0.2 | Results of co-immunoprecipitation, treatment with tyrosine kinase inhibitors and integrin inhibition experiments suggest that FAK is responsible for PMCA4b tyrosine phosphorylation during platelet activation. equence analysis indicates that Y(1176) is a likely substrate for focal adhesion kinase (FAK), while Y(1122) is... | SIGNOR-263194 |
Q9BXL7 | P62714 | 0 | dephosphorylation | down-regulates activity | 0.2 | NF-kappaB activation is triggered by PKCtheta-dependent phosphorylation of Carma1 after TCR/CD28 co-stimulation. PKCtheta-phosphorylated Carma1 was suggested to function as a molecular scaffold that recruits preassembled Bcl10-Malt1 complexes to the membrane|we demonstrate that PP2A removes PKCtheta-dependent phosphory... | SIGNOR-248607 |
P10645 | P16220 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.265 | Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response pr... | SIGNOR-254276 |
P49840 | P20807 | 0 | cleavage | up-regulates activity | 0.2 | Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase | SIGNOR-251606 |
P05112 | P35354 | 0 | null | up-regulates | 0.444 | Cox2 Is a Direct Srf Target Gene and Controls Il4 Expression | SIGNOR-255967 |
O96013 | O43426 | 1 | phosphorylation | up-regulates activity | 0.2 | We identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and recycling. Pacsin1 and Synaptojanin1 were phosphorylated by Pak5 and the other group II Paks in vitro, and Pak5 phosphorylation promoted Pacsin1-Synaptojanin1... | SIGNOR-263024 |
P48729 | P37840 | 1 | phosphorylation | up-regulates | 0.371 | In vitro experiments and two-dimensional phosphopeptide mapping provided further evidence that serine 129 was phosphorylated by ck-1 and ck-2. Moreover, phosphorylation of serine 129 was reduced in vivo upon inhibition of ck-1 or ck-2. These data demonstrate that alpha-synuclein is constitutively phosphorylated within ... | SIGNOR-73799 |
P49841 | P84022 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.488 | Mechanistically, axin facilitates gsk3-beta-mediated phosphorylation of smad3 at thr66, which triggers smad3 ubiquitination and degradation. | SIGNOR-160318 |
O00512 | P35222 | 2 | binding | up-regulates | 0.938 | The transcriptional activity of beta-catenin depends on bcl-9. Bcl-9 functions in targeting beta-catenin to the nucleus and thus increases the transcriptional activity of beta-catenin | SIGNOR-126059 |
P16298 | Q92934 | 1 | dephosphorylation | up-regulates activity | 0.364 | Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD|Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-xL and promoting apoptosis. | SIGNOR-248384 |
Q7Z5K2 | Q96FF9 | 2 | binding | down-regulates activity | 0.2 | We show that DNA replication and cohesin acetylation promote binding of Sororin to cohesin, and that Sororin displaces Wapl from its binding partner Pds5. | SIGNOR-265266 |
P43405 | Q13177 | 0 | phosphorylation | up-regulates activity | 0.271 | This is supported by in vitro studies showing that Pak2 phosphorylates and activates Syk. | SIGNOR-279083 |
P00533 | P63096 | 1 | phosphorylation | up-regulates activity | 0.464 | RTKs directly phosphorylate Gαi on Y154, 155, and Y320. | SIGNOR-277227 |
P62745 | P48729 | 0 | phosphorylation | down-regulates | 0.2 | Mass spectrometry analysis demonstrates that rhob is monophosphorylated by ck1, in its c-terminal end, on serine 185. lastly we show that the inhibition of ck1 activates rhob and promotes rhob dependent actin fiber formation and egf-r level. | SIGNOR-179255 |
P12931 | Q8NEB9 | 1 | phosphorylation | up-regulates activity | 0.42 | Given that VPS34 is activated by Src mediated tyrosine phosphorylation, we next determined if VPS34 was tyrosine phosphorylated following insulin treatment.|These data indicate that VPS34 is an effector of insulin-mediated signal transduction and that Src phosphorylation of VPS34 is required for this function. | SIGNOR-278456 |
P17612 | Q96SB3 | 1 | phosphorylation | down-regulates activity | 0.31 | Spinophilin is phosphorylated in vitro by protein kinase A (PKA). two major sites of phosphorylation, Ser-94 and Ser-177, that are located within the actin-binding domain of spinophilin. Phosphorylation of spinophilin by PKA modulated the association between spinophilin and the actin cytoskeleton. phosphorylation of sp... | SIGNOR-250035 |
P27361 | Q9H9Z2 | 1 | phosphorylation | down-regulates activity | 0.277 | Here we show that Lin28a is directly phosphorylated by ERK1/2 kinases at Ser-200. | SIGNOR-277337 |
P63096 | P48039 | 2 | binding | up-regulates activity | 0.476 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256706 |
P32121 | Q99835 | 2 | binding | up-regulates | 0.661 | Grk2-mediated phosphorylation of vertebrate smo allows smo to bind to beta-arrestins 1 or 2 | SIGNOR-132759 |
Q9H0K1 | P27986 | 1 | phosphorylation | up-regulates activity | 0.322 | The Regulatory Subunit of PI3K Is a Direct Catalytic Target of SIK2. These data confirm that p85α is a direct catalytic substrate of SIK2 and that SIK2 S154 phosphorylation significantly increases the activity of the PI3K/AKT pathway in ovarian cancer cells. | SIGNOR-277269 |
P22607 | P05230 | 2 | binding | up-regulates | 0.801 | Reports also show that fgf/fgfr3 signals mediate some of the effects of tgf-beta on embryonic bone formation | SIGNOR-195585 |
P29350 | P06241 | 0 | phosphorylation | up-regulates activity | 0.551 | By contrast, receptor multivalent aggregation induced a Fyn-dependent SHP-1 S591 phosphorylation (Fig.\u00a0 xref ).|Fyn simultaneously activates the PI3K-PKC\u03b1 pathway, leading to SHP-1 phosphorylation on serine 591. | SIGNOR-279716 |
Q04760 | P35916 | 0 | phosphorylation | up-regulates activity | 0.2 | We show that Glo1 activity is promoted by phosphorylation on Tyrosine 136 via multiple kinases. Glo1 Y136 is phosphorylated by multiple different kinases including all members of the Src family. Depletion of multiple different kinases led to a partial reduction in Glo1(Y136) phosphorylation. These included members of t... | SIGNOR-276180 |
P17676 | P35318 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.245 | These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. | SIGNOR-254047 |
Q5VWQ8 | P98082 | 2 | binding | up-regulates activity | 0.521 | In prostate cancer cells, DAB2IP was shown to be recruited by the adaptor protein DAB2/DOC2 to promote Ras inactivation and inhibition of MAPK signaling upon receptor stimulation. | SIGNOR-254744 |
P12034 | P21802 | 2 | binding | up-regulates | 0.702 | Fgf-5 can bind and induce autophosphorylation of human fgf receptors (fgfr) 1 and 2 | SIGNOR-38995 |
P35222 | P68400 | 0 | phosphorylation | up-regulates activity | 0.556 | The major CK2 phosphorylation site in this domain is Thr393, a solvent-accessible residue in a key hinge region of the molecule. Mutation of this single amino acid reduces beta-catenin phosphorylation, cotranscriptional activity, and stability. | SIGNOR-250849 |
Q03060 | P27361 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.41 | The MAPKs extracellular signal-regulated kinases 1 and 2 physically interact with ICER and mediated the phosphorylation of ICER on a critical serine residue (Ser-41). A mutant form of ICER in which Ser-41 was substituted by alanine had a half-life 4-5 h longer than its wild-type counterpart. This alteration in stabili... | SIGNOR-275978 |
Q96L34 | Q5BJF6 | 1 | phosphorylation | up-regulates activity | 0.516 | Collectively, our data indicate that MARK4 interacts with ODF2 in vivo and phosphorylates ODF2 in vitro.|Collectively, our data support the model that MARK4 promotes ciliogenesis by acting upstream of ODF2. | SIGNOR-278961 |
P36897 | P63000 | 1 | null | up-regulates activity | 0.28 | Thus, TGF-_1 rapidly stimulates activity of both RhoA and Rac1 and this activation requires ALK5/T_RI kinase activity. | SIGNOR-227496 |
Q13424 | P29475 | 1 | relocalization | up-regulates | 0.558 | biochemical studies showed that the N-terminal PDZ domain of nNOS binds to a similar PDZ domain of syntrophin (Fig. 1), a dystrophin-associated protein | SIGNOR-236916 |
Q09472 | P35222 | 2 | binding | up-regulates | 0.705 | Ctnnb1 forms a ternary complex with lef1 and ep300 that is disrupted by ctnnbip1 binding | SIGNOR-76987 |
P24941 | Q12834 | 1 | phosphorylation | down-regulates activity | 0.684 | Here we show that cyclin A2-Cdk2 binds and phosphorylates Cdc20 in interphase and this inhibits APC/C-Cdc20 activity.|Interphase APC/C-Cdc20 inhibition by cyclin A2-Cdk2 ensures efficient mitotic entry. | SIGNOR-279322 |
P60484 | P35568 | 1 | dephosphorylation | down-regulates activity | 0.576 | In contrast, IRS-1 level were significantly decreased and phosphorylation of IRS-1 at Ser 307 was strongly enhanced by PTEN knockdown, suggesting that both reduction in IRS-1 level and increase in IRS-1 phosphorylation at Ser307 upon HCV infection occurred in a PTEN dependent manner.|In contrast, IRS-1 level were signi... | SIGNOR-277078 |
Q13829 | P68400 | 0 | phosphorylation | up-regulates | 0.2 | It was demonstrated that ck2 could phosphorylate tnfaip1 in vitro and in vivo, which facilitated the distribution of tnfaip1 in nucleus and enhanced its interaction with pcna. It is suggested that the phosphorylation of tnfaip1 may be required for its functions. | SIGNOR-188849 |
P30154 | P67775 | 2 | binding | up-regulates activity | 0.943 | Since B_ suppresses the association of the catalytic C and regulatory A subunits of protein phosphatase 2A [94], the B_ interaction with the receptor is expected to result in enhanced protein phosphatase 2A activity | SIGNOR-217872 |
Q86XK2 | P41182 | 2 | binding | down-regulates | 0.49 | Fbxo11 targets bcl6 for degradation | SIGNOR-177652 |
Q9BXS5 | Q2M2I8 | 0 | phosphorylation | up-regulates | 0.2 | Aak1 is enriched at presynaptic terminals, whereas in nonneuronal cells it colocalizes with clathrin and ap2 in clathrin-coated pits and at the leading edge of migrating cells. Aak1 specifically phosphorylates the mu subunit in vitro, and stage-specific assays for endocytosis show that mu phosphorylation by aak1 result... | SIGNOR-115589 |
Q13009 | P48729 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.309 | Phosphorylation of Ser329, Ser334, and Thr340 in Tiam1 is required for its interaction with βTrCP1. The proteolysis of Tiam1 is prevented by βTrCP silencing, inhibition of CK1 and MEK, or mutation of the Tiam1 degron site. | SIGNOR-276673 |
P19544 | P00441 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.265 | The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. Egr-1 and two splicing variants of the Egr-related protein WT1 were able to transactivate the SOD1 promoter in co-transfection experiments. | SIGNOR-253898 |
P10997 | P29120 | 0 | cleavage | up-regulates activity | 0.446 | The processing of proinsulin to insulin occurs in the secretory granules at the C-terminal end of pairs of basic amino acids, Arg31-Arg32 and Lys64-Arg65 [9,10]. Following cleavage, by the prohormone convertases, PC3 (also known as PC1) and PC2, the pair of basic amino acids are removed rapidly by carboxypeptidase E (C... | SIGNOR-261782 |
P48431 | Q9NQU5 | 0 | phosphorylation | up-regulates quantity | 0.2 | PAK5 promotes the cell stemness ability by phosphorylating SOX2 in lung squamous cell carcinomas.|The absence of PAK5 abolishes self-renewal ability of LUSC cells by decreasing the expression and phosphorylation of SOX2 in vitro and in vivo. | SIGNOR-280060 |
Q15077 | Q14344 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257398 |
Q96P31 | P29350 | 2 | binding | up-regulates activity | 0.39 | Tyrosine phosphorylation of SPAP2a by c-Src and in vitro. Tyrosine-phosphorylated SPAP2 is specifically associated with SH2 domain-containing tyrosine kinases Syk and Zap70 and SH2 domain-containing tyrosine phosphatases SHP-1 and SHP-2. Site-specific mutagenesis studies revealed that tyrosyl residues 650 and 662 embed... | SIGNOR-274013 |
Q96HS1 | P48163 | 1 | dephosphorylation | up-regulates activity | 0.2 | PGAM5-mediated dephosphorylation of malic enzyme 1 (ME1) at S336 allows increased ACAT1-mediated K337 acetylation, leading to ME1 dimerization and activation, both of which are reversed by NEK1 kinase-mediated S336 phosphorylation. SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusiv... | SIGNOR-275569 |
P15498 | P61586 | 1 | guanine nucleotide exchange factor | up-regulates activity | 0.75 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260580 |
P43378 | P04626 | 1 | dephosphorylation | down-regulates activity | 0.304 | Conversely, increasing expression of PTPN9 wild type (WT) inhibits tyrosyl phosphorylation of ErbB2 and EGFR.|Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells. | SIGNOR-277170 |
Q13233 | P01116 | 2 | binding | up-regulates | 0.366 | Mitogen-activated protein kinase kinase kinase (mekk1) is a serine-threonine kinase that regulates sequential protein kinase pathways involving stress-activated protein kinases and mitogen-activated protein kinases. Mekk1 is activated in response to growth factor stimulation of cells and by expression of activated ras.... | SIGNOR-32620 |
P17706 | O00401 | 1 | dephosphorylation | down-regulates | 0.29 | Similarly, the t cell phosphatase has a 30-fold lower kcat/km toward autoinhibited p-n-wasp than toward the isolated p-gbd, and again this effect is largely reversed by that cdc42 | SIGNOR-141652 |
Q6ZMZ0 | P68036 | 2 | binding | up-regulates activity | 0.481 | We demonstrated that both UbcH7 and UbcH8 bind to full-length NKLAM. We demonstrated decreased protein expression and enhanced ubiquitination of URKL-1 in the presence of NKLAM. These data indicate that NKLAM is a RING finger protein that binds Ubcs and | SIGNOR-271591 |
P43353 | Q9NXK8 | 2 | binding | down-regulates quantity by destabilization | 0.32 | We now show that SCFFBXL12 is an authentic E3 for the ALDH3 family of enzymes. We now show that the ubiquitin-dependent degradation of ALDH3 mediated by FBXL12 (F box and leucine-rich repeat protein 12) is essential for execution of the differentiation program of trophoblast stem cells (TSCs). FBXL12 is present only in... | SIGNOR-272815 |
Q9NP62 | Q9UKT8 | 2 | binding | down-regulates quantity | 0.538 | FBW2 targets GCMa to the ubiquitin-proteasome degradation system. Here, we report the identification of an SCF complex as the GCM ubiquitin-protein isopeptide ligase (E3) that regulates human GCMa (hGCMa) degradation. We found that SKP1 and CUL1, two key components of the SCF complex, associate with hGCMa in vivo. We f... | SIGNOR-271524 |
Q03591 | P08603 | 2 | binding | down-regulates activity | 0.504 | Finally, we have been able to establish that CFHR1 can sterically inhibit the interaction that CFH/CFHL-1 SCR1-4 makes with C3b.|CFH regulates the alternative pathway of complement in both the fluid phase and on self-surfaces: It competes with complement factor B (CFB) for binding to C3b and C3(H2O) thereby blocking th... | SIGNOR-263476 |
P63092 | Q14831 | 2 | binding | up-regulates activity | 0.357 | MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G p... | SIGNOR-264080 |
Q9UKT8 | Q9NP62 | 2 | binding | down-regulates quantity | 0.538 | FBW2 targets GCMa to the ubiquitin-proteasome degradation system. Here, we report the identification of an SCF complex as the GCM ubiquitin-protein isopeptide ligase (E3) that regulates human GCMa (hGCMa) degradation. We found that SKP1 and CUL1, two key components of the SCF complex, associate with hGCMa in vivo. We f... | SIGNOR-271524 |
Q16539 | P10415 | 1 | phosphorylation | down-regulates activity | 0.334 | Bcl-2 phosphorylation by p38 mapkin this study, we identify, by using mass spectrometry techniques and specific anti-phosphopeptide antibodies, ser(87) and thr(56) as the bcl-2 residues phosphorylated by p38 mapk and show that phosphorylation of these residues is always associated with a decrease in the antiapoptotic p... | SIGNOR-146786 |
P35354 | Q12968 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.279 | NFAT induces the transcription of the COX2 (cyclo-oxygenase-2) gene incancer cells thereby enhancing invasive migration | SIGNOR-264028 |
Q02297 | P04626 | 2 | binding | up-regulates | 0.792 | Direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3. | SIGNOR-26875 |
Q9BW19 | Q13535 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.257 | ATM and ATR kinases phosphorylate KIFC1-S26 during DNA-damage conditions.KIFC1 was stabilized upon phosphorylation and thus promoted centrosome clustering, CIN, and tumor recurrence both in vivo and in vitro. | SIGNOR-277296 |
Q15722 | Q03113 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257196 |
P08754 | O95136 | 2 | binding | up-regulates activity | 0.387 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256871 |
P62256 | P17542 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.326 | Tal1 expression activated UBE2H expression, whereas Tal1 knock-down reduced UBE2H expression and ubiquitin transfer activity.|Binding of Tal1 to UBE2H was confirmed by chromatin immunoprecipitation. | SIGNOR-269000 |
Q8TDB6 | P62805 | 1 | monoubiquitination | down-regulates activity | 0.2 | Herein, we demonstrate that BBAP selectively monoubiquitylates histone H4 lysine 91 and protects cells exposed to DNA-damaging agents. Disruption of BBAP-mediated monoubiquitylation of histone H4K91 is associated with the loss of chromatin-associated H4K20 methylase, mono- and dimethyl H4K20, and a delay in the kinetic... | SIGNOR-271897 |
Q96R06 | P53350 | 0 | phosphorylation | up-regulates activity | 0.394 | Phosphorylation of the astrin N-terminal domain by Plk1 contributes to kinetochore\u2013microtubule attachment stability.|Taken together with the localisation data in XREF_FIG B, these data suggest that the presence of the Plk1 phosphorylated astrin N-terminus promotes the accumulation of the astrin complex at attached... | SIGNOR-279423 |
P05549 | P54646 | 0 | phosphorylation | up-regulates activity | 0.307 | Inhibition of AMPKalpha2 with either siRNA or compound C significantly suppressed the AngII- or nicotine enhanced AP-2alpha activity and the binding of AP-2alpha to DNA.|We report that nicotine, a major component of cigarette smoke, activates AMPK in VSMCs and that AMPKalpha2 phosphorylates AP-2alpha at serine 219 resu... | SIGNOR-279648 |
P60510 | Q9GZM8 | 1 | dephosphorylation | down-regulates activity | 0.395 | Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation|PP4c selectively dephosphorylates NDEL1 at Cdk1 sites. We also demonstrate that PP4c negatively regulates Cdk1 activity at the centrosome.|We next examined the ability of PP4c to dephosphorylate a Cd... | SIGNOR-248550 |
P08069 | O14654 | 1 | phosphorylation | up-regulates | 0.657 | Insulin-like growth factor i acting through its receptor was as effective as insulin in eliciting tyrosine phosphorylation of irs-4. | SIGNOR-56604 |
P81274 | Q96KB5 | 0 | phosphorylation | up-regulates | 0.27 | We found that the 450th threonine (thr450) of lgn/gpsm2 was phosphorylated by the serine/threonine kinase pbk/topk during mitosis. Western blot analysis indicated the highest expression and the phosphorylated form of lgn/gpsm2 protein in g2/m phase. | SIGNOR-166461 |
Q9HCK8 | Q9HD90 | 1 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268918 |
Q15303 | P62993 | 2 | binding | up-regulates | 0.83 | Egfr and erbb4 had several docking sites for grb2, while erbb3 was characterized by six binding sites for pi3k. Egfr has six binding sites for the adapter protein grb2, and erbb4 has five, each with different binding strength. | SIGNOR-146876 |
Q13315 | Q5XUX0 | 1 | phosphorylation | up-regulates | 0.406 | We find that dna damage induced by gamma-irradiation results in increased fbxo31 levels, which requires phosphorylation of fbxo31 by the ddr-initiating kinase atm | SIGNOR-185635 |
Q7L7X3 | Q13043 | 1 | phosphorylation | up-regulates | 0.368 | In addition, the thousand-and-one (tao) amino acids kinase or taok13 has been shown to directly phosphorylate and activate hpo or mst1/2. | SIGNOR-201324 |
O14965 | Q9ULW0 | 1 | phosphorylation | up-regulates activity | 0.965 | Here we show that TPX2, a microtubule-bundling protein and activator of Aurora A, plays an important role. TPX2 was phosphorylated by Aurora A during mitosis. Its phospho-null mutant caused short metaphase spindles coupled with low microtubule flux rate. Interestingly, phosphorylation of TPX2 regulated its interaction ... | SIGNOR-265089 |
Q7Z2W4 | Q14258 | 0 | ubiquitination | up-regulates activity | 0.398 | Our data demonstrates that TRIM25 triggers ubiquitination of ZAP and enhances its antiviral activity through inhibition of viral translation, highlighting the importance of cofactors in the mechanisms of broadly antiviral proteins. | SIGNOR-278565 |
Q9H2X6 | Q9NY61 | 1 | phosphorylation | down-regulates quantity | 0.346 | HIPK2 phosphorylates Che-1.|Here we demonstrate that HIPK2, a proapoptotic kinase, is involved in Che-1 degradation. | SIGNOR-278942 |
P49662 | Q63HK5 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.27 | Chromatin immunoprecipitation showed a direct interaction of FE65 and Teashirt3 with the promoter region of CASP4. The results were consistent with a model in which reduced expression of Teashirt3, mediated by genetic or other causes, increases caspase-4 expression, leading to progression of AD. | SIGNOR-264815 |
P01137 | P35555 | 2 | binding | up-regulates quantity | 0.489 | We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a major contributor to the pathology of Marfan syndrome (MFS) and related ... | SIGNOR-251888 |
P63000 | Q8N1I0 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.586 | DOCK4 (dedicator for cytokinesis 4), a guanine nucleotide exchange factor (GEF) for the small GTPase Rac1, is one of few genes that are associated with both ASD and dyslexia. | SIGNOR-266823 |
P46527 | O60674 | 0 | phosphorylation | down-regulates activity | 0.696 | JAK2 phosphorylates tyrosine residue 88 (Y88) of p27(Kip1). | SIGNOR-278260 |
Q15303 | P27361 | 0 | phosphorylation | down-regulates activity | 0.534 | We also identified Ser-1026 as an ErbB4-specific ERK target site in the CYT-1 region. Moreover, double mutations (Thr-674/Ser-1026 to Ala) significantly upregulated ErbB4 activation, indicating that Thr-674 and Ser-1026 are cooperatively involved in negative feedback regulation. | SIGNOR-277448 |
Q13555 | P07101 | 1 | phosphorylation | up-regulates activity | 0.332 | In both isoforms, Ser-40 was found to be phosphorylated by PKA, and Ser-19 and Ser-40 were found to be phosphorylated by CaM-PK II. The putative phosphorylation site generated by alternative splicing (Ser-31) was phosphorylated specifically by CaM-PK II in TH-2 only. | Unlike TH-1, phosphorylation of TH-2 by CaM-PK II... | SIGNOR-250709 |
Q9Y253 | P51587 | 2 | binding | up-regulates | 0.553 | Palb2 and brca2 interact with pol_ and are required to sustain the recruitment of pol_ at blocked replication forks. Palb2 and brca2 stimulate pol_-dependent dna synthesis on d loop substrates | SIGNOR-204538 |
P62136 | Q9UD71 | 2 | binding | down-regulates activity | 0.599 | DARPP-32 (dopamine and cyclic AMP-regulated phospho-protein, relative molecular mass 32,000) is converted into an inhibitor of protein phosphatase 1 when it is phosphorylated by protein kinase A (PKA) at threonine 34.‚ | SIGNOR-264957 |
O43255 | Q9Y6H5 | 1 | ubiquitination | down-regulates | 0.62 | Siah proteins ubiquitylate synphilin-1 and promote its degradation through the ubiquitin proteasome system | SIGNOR-140651 |
Q00722 | P62873 | 2 | binding | up-regulates | 0.554 | Activation of plc-beta 2 by beta gamma subunits may be an important mechanism by which pertussis toxin-sensitive g proteins stimulate plc. | SIGNOR-19447 |
P51812 | P18846 | 1 | phosphorylation | up-regulates activity | 0.318 | ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB.|ATF1 ... | SIGNOR-280117 |
P38405 | P30559 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256936 |
P57059 | Q6UUV9 | 1 | phosphorylation | down-regulates | 0.494 | These results suggested that sik1 could phosphorylate all torcs and thereby repress their transactivation activities. | SIGNOR-147669 |
Q9Y5Z9 | P01112 | 2 | binding | down-regulates activity | 0.2 | This study show that UBIAD1 interacts with H-Ras, retains H-Ras in the Golgi apparatus, prevents H-Ras trafficking from the Golgi apparatus to the plasma membrane, blocks the aberrant activation of Ras/MAPK signaling, and inhibits the proliferation of bladder cancer cells. | SIGNOR-256206 |
P25098 | Q8IXH6 | 1 | phosphorylation | down-regulates activity | 0.2 | In conclusion, experimental results demonstrate that GRK2 chronically downregulates DOR functional competence at the PM in peripheral sensory neurons, as well as peripheral DOR anti-nociception in vivo.|These data demonstrate that BK does not affect GRK2 mediated phosphorylation of DOR at its primary desensitization si... | SIGNOR-279739 |
Q13557 | P13688 | 1 | phosphorylation | up-regulates | 0.2 | Camkiid specifically phosphorylates thr-457 on ceacam1-sf, which in turn regulates the process of lumen formation via apoptosis of the central acinar cells. | SIGNOR-203402 |
Q13489 | Q13489 | 2 | ubiquitination | down-regulates activity | 0.2 | Ciap1 and ciap2 undergo autoubiquitination and degradation upon binding to the iap antagonist second mitochondrial activator of caspases (smac)/direct iap-binding protein with low pi (diablo), which is released from the mitochondria. | SIGNOR-121880 |
Q00535 | Q9Y490 | 1 | phosphorylation | up-regulates | 0.458 | Cdk5 phosphorylated talin head at ser 425, inhibiting its binding to smurf1, thus preventing talin head ubiquitylation and degradation. | SIGNOR-185210 |
Q92968 | O75381 | 2 | binding | up-regulates activity | 0.92 | Pex14 interacts via its proline-rich motif with the SH3 domain of Pex13. We conclude that the association of Pex13 with Pex14 is an essential step in peroxisomal protein import | SIGNOR-253029 |
Q6P0Q8 | P48764 | 1 | phosphorylation | down-regulates activity | 0.456 | Coexpression of MAST205 inhibits the activity of Na +/H+ exchanger NHE3.|Consistent with these results, we found that MAST205 phosphorylated NHE3 under in vitro conditions. | SIGNOR-279229 |
Q12974 | P24941 | 1 | dephosphorylation | up-regulates | 0.2 | Cells overexpressing prl-2 exhibited enhanced cyclin-dependent kinase 2 (cdk2) activity | SIGNOR-119478 |
P46527 | O15111 | 0 | phosphorylation | down-regulates activity | 0.372 | Reduced nuclear p27 was also found in MCF7 human breast cancer cells that were transiently transfected with an IKKalpha expression vector; increased IKKalpha expression resulted in a dose dependent decrease in nuclear p27 and increased cytoplasmic p27 (XREF_FIG).|We found that IKKalpha phosphorylates p27 at S183 to cau... | SIGNOR-278438 |
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