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https://arxiv.org/abs/2401.15713 • 11 items • Updated
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Interleukin-1 inhibition has revealed to be a successful treatment approach for patients with adult-onset Still's disease (AOSD).,However, real-life experience is focused on the use of anakinra, while data about canakinumab (CAN) are mainly based on case reports and small case series.,Patients and Methods.,Patients cla... | GM-CSF is a potential therapeutic target in inflammation and autoimmunity.,This study reviews the literature on the biology of GM-CSF, in particular that describing the research leading to clinical trials targeting GM-CSF and its receptor in numerous inflammatory/autoimmune conditions, such as rheumatoid arthritis.,Gra... | 1 |
In order to better understand the perspectives of patients and physicians regarding the treatment and management of rheumatoid arthritis (RA), we present and compare results from a patient-based and a physician-based survey developed by the RA NarRAtive advisory panel.,The RA NarRAtive initiative is directed by a globa... | To assess the clinical evidence for bee venom acupuncture (BVA) for rheumatoid arthritis (RA).,Systematic review of randomised controlled trials (RCTs).,We searched 14 databases up to March 2014 without a language restriction.,Patients with RA.,BVA involved injecting purified, diluted BV into acupoints.,We included tri... | 1 |
Monocytes function as crucial innate effectors in the pathogenesis of chronic inflammatory diseases, including autoimmunity, as well as in the inflammatory response against infectious pathogens.,Human monocytes are heterogeneous and can be classified into three distinct subsets based on CD14 and CD16 expression.,Althou... | Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia.,In addition to strong association within the HLA region at 6p21 (Pmeta=7.65×10−114), we establish associations with IRF5-TNPO3 (Pmeta=2.73×10−19), STAT4 (Pmeta=6.80×10−15), ... | 1 |
To investigate autoantigens in β-cells, we have used a panel of pathogenic T-cell clones that were derived from the NOD mouse.,Our particular focus in this study was on the identification of the target antigen for the highly diabetogenic T-cell clone BDC-5.2.9.,To purify β-cell antigens, we applied sequential size excl... | Although type 1 diabetes autoimmunity frequently begins in childhood, little is known about the relationship between age and autoimmunity development.,Our aim was to determine the timing of seroconversion to diabetes-associated autoantibody (DAA) positivity and risk in first- and second-degree relatives of patients wit... | 1 |
The purpose of the present studies was to investigate the impact of chronic inflammation of the lacrimal gland, as occurs in Sjögren’s syndrome, on the morphology and function of myoepithelial cells (MECs).,In spite of the importance of MECs for lacrimal gland function, the effect of inflammation on MECs has not been w... | Primary Sjögren’s Syndrome (PSS) mainly affects women (9:1 female:male ratio) and is one of the commonest autoimmune diseases with a prevalence of 0.1 - 0.6% of adult women.,For patients with PSS there is currently no effective therapy that can alter the progression of the disease.,The aim of the TRACTISS study is to e... | 1 |
The etiology of rheumatoid arthritis (RA) remains poorly understood.,Early and accurate diagnosis still difficult to achieve.,Inflammatory related molecules released into the circulation such cytokines and exosome-derived microRNAs (exomiRNAs) could be good candidates for early diagnosis of autoimmune diseases.,We soug... | Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that is associated with inflammation and dysfunction of salivary and lacrimal glands.,The molecular mechanism(s) underlying this exocrinopathy is not known, although the syndrome has been associated with viruses, such as the Epstein Barr Virus (EBV).,We ... | 1 |
Objective.,Non-adherence to DMARDs is common, but little is known about adherence to biologic therapies and its relationship to treatment response.,The purpose of this study was to investigate the association between self-reported non-adherence to s.c. anti-TNF therapy and response in individuals with RA.,Methods.,Part... | Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients.,However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown.,Th... | 1 |
The rise in the prevalence of autoimmune diseases in developed societies has been associated with a change in lifestyle patterns.,Among other factors, increased consumption of certain dietary components, such as table salt and fatty acids and excessive caloric intake has been associated with defective immunological tol... | Interleukin (IL)-17-producing T helper cells (TH17) are a recently identified CD4+ T cell subset distinct from T helper type 1 (TH1) and T helper type 2 (TH2) cells1.,TH17 cells can drive antigen specific autoimmune diseases and are considered the main population of pathogenic T cells driving experimental autoimmune en... | 1 |
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin are the targets of injury.,Metals are essential for normal CNS functioning, and metal imbalances have been linked to demyelina... | Autoimmune diseases of the central nervous system (CNS) involve inflammatory components and result in neurodegenerative processes.,Microglia, the resident macrophages of the CNS, are the first responders after insults to the CNS and comprise a major link between the inflammation and neurodegeneration.,Here, we will foc... | 1 |
The incidence of type 1 diabetes mellitus (T1DM) increased worldwide.,The objective of the paper was to compare the incidence trend of T1DM in children and adolescents aged 0-19 and in adults under 30 years of age in Serbia from 2006 to 2017.,Additional aim was to compare incidence rates of T1DM and type 2 diabetes mel... | To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18-50.,Multivariable logistic regression analysis was used to develop classification models integrating five pre-specified predictor variables, including clinical features (age of ... | 1 |
To investigate the efficacy, safety, immunogenicity and pharmacokinetics of biosimilar adalimumab (ADL) PF-06410293 (ADL-PF; adalimumab-afzb) versus EU-sourced reference ADL (ADL-EU) in patients with active rheumatoid arthritis (RA) on longer-term treatment and after being switched from ADL-EU to ADL-PF.,In this multin... | To investigate the efficacy, safety and immunogenicity of PF-06438179/GP1111 (PF-SZ-IFX) compared with European reference infliximab (Remicade®; ref-IFX) in patients with moderate-to-severe, active rheumatoid arthritis after continued long-term use of PF-SZ-IFX, and in patients who were switched from ref-IFX to PF-SZ-I... | 1 |
Serum phagocyte-derived alarmins S100A8/9 and S100A12 are considered useful for the assessment of inflammatory diseases.,Our study evaluated the use of S100 proteins in a pediatric clinical setting for estimating disease activity and supporting diagnosis.,Patients (n = 136) who had S100 proteins tested as part of clini... | The involvement of high mobility group box-1 (HMGB1) in various inflammatory and autoimmune diseases has been documented but clinical trials on the contribution of this pro-inflammatory alarmin in children with juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE) are basically absent.,To address t... | 1 |
Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).,Transfer of antibodies against COL7 into mice results in a subepidermal blistering phenotype, strictly depending on the complement component C5.,... | Pemphigus vulgaris (PV) is a potentially fatal blistering disease caused by autoantibodies against desmoglein 3 (Dsg3).,Here, we clone anti-Dsg3 antibodies from four PV patients and identify pathogenic VH1-46 autoantibodies from all four patients.,Unexpectedly, VH1-46 autoantibodies had relatively few replacement mutat... | 1 |
Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions1,2 (www.T1DBase.org) revealing major pathways contributing to risk3, with some loci shared across immune disorders4-6.,In order to make genetic comparisons across autoimmune disorders as informative as possible a dense genotyping array, ... | Studies in NOD mice have provided important insight into the genetics and pathogenesis of type 1 diabetes (T1D).,Our goal was to further explore novel methods of genetic manipulation in this mouse model.,We tested the feasibility of using zinc-finger nucleases (ZFNs) to knock out a gene directly in a pure NOD backgroun... | 1 |
Rheumatoid arthritis is a common systemic and autoimmune disease characterized by symmetrical and inflammatory destruction of distal joints.,Its primary pathological characters are synovitis and vasculitis.,Accumulating studies have implicated the critical role of non-coding RNAs (ncRNAs) in inflammation and autoimmune... | Synovial tissue is a membranous non-immune organ lining joint cavities where it supports local immune responses, and functions directly and indirectly in joint destruction due to chronic inflammatory diseases such as rheumatoid arthritis (RA).,Fibroblast-like synoviocytes (FLS), the dominant non-immune cells of synovia... | 1 |
Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population.,Extracellular vesicles (EVs), including exosomes and microvesicles, are now recognized to play important roles in cell-to-cell communication by transporting various proteins, microRNAs... | In rheumatoid arthritis, prediction of response to TNF-alpha inhibitor (TNFi) treatment would be of clinical value.,This study aims to discover miRNAs that predict response and aims to replicate results of two previous studies addressing this topic.,From the observational BiOCURA cohort, 40 adalimumab- (ADA) and 40 eta... | 1 |
Multiple sclerosis (OMIM 126200) is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability.1 Epidemiological studies have shown that genetic f... | Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored.,Previous studies demonstrate that 6 of the established non-HLA CD and RA risk loci (out of 26 loci for each disease) are sha... | 1 |
Epstein-Barr virus (EBV) infection may be necessary for the development of Multiple sclerosis (MS).,Earlier we had identified six MS risk loci that are co-located with binding sites for the EBV transcription factor Epstein-Barr Nuclear Antigen 2 (EBNA2) in EBV-infected B cells (lymphoblastoid cell lines - LCLs).,We use... | A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS).,Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS patients leading to intrathecal B-cell transformation.,Consequent T-cel... | 1 |
Pain remains the most important problem for people with rheumatoid arthritis (RA).,Active inflammatory disease contributes to pain, but pain due to non-inflammatory mechanisms can confound the assessment of disease activity.,We hypothesize that augmented pain processing, fibromyalgic features, poorer mental health, and... | Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children.,Synovial inflammation results in pain, swelling and stiffness.,Animal and adult human studies indicate that localized joint-associated inflammation may produce generalized changes in pain sensitivity.,The aim ... | 1 |
To report the understanding and decision-making of neuroimmunologists and their treatment of patients with multiple sclerosis (MS) during the early stages of the SARS-CoV-2 (COVID-19) outbreak.,A survey instrument was designed and distributed online to neurologists in April 2020.,There were 250 respondents (response ra... | •90% of MS patients knew that COVID-19 is in a pandemic stage.•73% followed quarantine guidelines completely.,•All participants believed high person-to-person transmission rate of COVID-19.,90% of MS patients knew that COVID-19 is in a pandemic stage.,73% followed quarantine guidelines completely.,All participants beli... | 1 |
: Development of long-term immunologic memory relies upon humoral and cellular immune responses.,Vaccinations aim to stimulate these responses against pathogens.,Several studies have evaluated the impact of multiple sclerosis disease-modifying therapies on immune response to vaccines.,Findings from these studies have i... | To evaluate the safety, efficacy, and durability of multiple sclerosis (MS) disease stabilization after high-dose immunosuppressive therapy (HDIT) and autologous hematopoietic cell transplantation (HCT).,High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT-MS) is a phase II clinical t... | 1 |
Aberrant histone acetylation and deacetylation are increasingly thought to play important roles in the pathogenesis of rheumatoid arthritis (RA).,However, limited data from studies about the activity of histone deacetylases (HDACs) and histone acetyltransferase (HAT) in RA are controversial.,Those conflicting results m... | Background: Rheumatoid arthritis (RA) is a inflammatory disease that characterized with the destruction of synovial joint, which could induce disability.,Inflammatory response mediated the RA.,It has been reported that MiR-128-3p is significantly increased in RA, while the potential role was still unclear.,Methods: T c... | 1 |
To demonstrate clinical equivalence of adalimumab biosimilar candidate BI 695501 with Humira.,Patients with active rheumatoid arthritis on stable methotrexate were randomised to BI 695501 or Humira in a double-blind, parallel-group, equivalence study.,At week 24, patients were rerandomised to continue BI 695501 or Humi... | SB5 is a biosimilar agent for adalimumab (ADA).,The aim of this study was to evaluate the efficacy, pharmacokinetics (PK), safety, and immunogenicity of SB5 in comparison with reference ADA in patients with rheumatoid arthritis (RA).,In this phase III, randomized, double‐blind, parallel‐group study, patients with moder... | 1 |
Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE).,This study tested miR-146a and its target gene TRAF6 expression in LN patients and discussed their relationship with LN.,One hundred twenty-eight LN patients and 30 healthy controls were enrolled in this study.,MiR-146a and TRAF6 expres... | MicroRNAs control the differentiation and function of B cells, which are considered key elements in the pathogenesis of systemic lupus erythematosus (SLE).,However, a common micro(mi)RNA signature has not emerged since published data includes patients of variable ethnic background, type of disease, and organ involvemen... | 1 |
To determine whether genetic variation within genes related to the Toll-like receptor, inflammasome and interferon-γ pathways contributes to the differences in treatment response to tumour necrosis factor inhibitors (anti-TNF) in patients with rheumatoid arthritis (RA).,In a retrospective case-case study, we assessed 2... | Many patients with rheumatoid arthritis (RA) benefit from tumor necrosis factor-α blocking treatment (anti-TNF), but about one third do not respond.,The objective of this study was to replicate and extend previously found associations between anti-TNF treatment response and genetic variation in the TNF-, NF-κB- and pat... | 1 |
A long-term neurologic sequela arising from COVID-19 infection in multiple sclerosis (MS) patients could be related both to the increase of cytokines and the activation of NLRP3 inflammasome by the Sars-CoV2.,These two mechanisms may cause a worsening of MS several months after the resolution of the infection. | Individuals with pre-existing chronic illness have shown increased anxiety and depression due to COVID-19.,Here, we examine the impact of the COVID-19 pandemic on emotional symptomatology and quality of life in individuals with Progressive Multiple Sclerosis (PMS).,Data were obtained during a randomized clinical trial ... | 1 |
The emergency represented by the COVID-19 pandemic represents a new challenge for clinicians who deal with autoimmune diseases because of patients undergoing immunosuppressive therapy.,Few cases of Multiple Sclerosis (MS) patients receiving ocrelizumab who contracted COVID-19 with a benign course have recently been pub... | A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days.,High levels of CCL5 and CCL10 chemokines and of antibody-secreting B cells were detected, while the levels other B- and T-cell subsets were comparable to that of appr... | 1 |
Patients with systemic lupus erythematosus (SLE) have a significant increase in cardiovascular (CV) risk although they display a preserved number of circulating angiogenic CD3+CD31+CXCR4+ T cells (Tang), a subpopulation of T cells which promotes repair of damaged endothelium.,This happens due to the concomitant expansi... | Umbilical cord (UC)‐derived mesenchymal stem cells (MSCs) show immunoregulatory properties on various immune cells and display therapeutic effects on various autoimmune diseases such as systemic lupus erythematosus (SLE).,The aim of this study was to investigate the effect of the SLE environment on UC MSCs and to ident... | 1 |
Using a novel model of rheumatoid arthritis, we identified a critical role for reduced tissue-resident macrophages.,Little is known about the mechanisms regulating the transition of circulating monocytes into pro- or anti-inflammatory macrophages in chronic inflammation.,Here, we took advantage of our novel mouse model... | Increased expression of toll-like receptor 4 (TLR4) and its endogenous ligands, is characteristic of rheumatoid arthritis (RA) synovitis.,In this study, we evaluated how these TLR4 ligands may drive pathogenic processes and whether the fine profiling of anti-citrullinated protein antibodies (ACPA) based on their target... | 1 |
The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression.,Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care.,This European burden of illness study provides data that can be combined with oth... | Quetiapine (Que), a commonly used atypical antipsychotic drug (APD), can prevent myelin from breakdown without immune attack.,Multiple sclerosisis (MS), an autoimmune reactive inflammation demyelinating disease, is triggered by activated myelin-specific T lymphocytes (T cells).,In this study, we investigated the potent... | 1 |
‘No evidence of disease activity’ (NEDA), defined as absence of magnetic resonance imaging activity (T2 and/or gadolinium-enhanced T1 lesions), relapses and disability progression (‘NEDA-3’), is used as a comprehensive measure of treatment response in relapsing multiple sclerosis (RMS), but is weighted towards inflamma... | To assess whether it is feasible to establish specific cut-off values able to discriminate ‘physiological’ or ‘pathological’ brain volume rates in patients with multiple sclerosis (MS).,The study was based on the analysis of longitudinal MRI data sets of patients with MS (n=206, 87% relapsing-remitting, 7% secondary pr... | 1 |
The diet represents one environmental risk factor controlling the progression of type 1 diabetes (T1D) in genetically susceptible individuals.,Consequently, understanding which specific nutritional components promote or prevent the development of disease could be used to make dietary recommendations in prediabetic indi... | Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and is characterized by the presence of hyperactive immune cells and aberrant antibody responses to nuclear and cytoplasmic antigens, including characteristic anti-double-stranded DNA antibodies.,We performed a cross-sectional ... | 1 |
Vitamin D (VitD) insufficiency is common in multiple sclerosis (MS).,VitD has possible anti-inflammatory effects on the immune system.,The ratio between VitD metabolites in MS patients and the severity of the disease are suggested to be related.,However, the exact effect of the bone-derived hormone fibroblast-growth-fa... | Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis.,VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free for... | 1 |
To develop and validate multivariable clinical diagnostic models to assist distinguishing between type 1 and type 2 diabetes in adults aged 18-50.,Multivariable logistic regression analysis was used to develop classification models integrating five pre-specified predictor variables, including clinical features (age of ... | Specific autoantibodies characterize type 1 diabetes in childhood but are also found in adult-onset diabetes, even when initially non-insulin requiring, e.g., with latent autoimmune diabetes (LADA).,We aimed to characterize adult-onset autoimmune diabetes.,We consecutively studied 6,156 European diabetic patients atten... | 1 |
In this observational study, 159 patients with multiple sclerosis received personalized dosing of ocrelizumab incentivized by the COVID-19 pandemic.,Re-dosing was scheduled when CD19 B-cell count was ⩾10 cells/µL (starting 24 weeks after the previous dose, repeated 4-weekly).,Median interval until re-dosing or last B-c... | Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS.,Therefore, it was interestingly to find that current... | 1 |
ST266 is the biological secretome of cultured Amnion-derived Multipotent Progenitor cells containing multiple growth factors and cytokines.,While intranasally-administered ST266 improves the phenotype in experimental optic neuritis, specific ST266 components mediating these effects are not known.,We compared the effect... | The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental autoimmune encephalomyelitis animal model of multiple sclerosis was assessed.,Currently, there are no existing optic nerve treatment methods f... | 1 |
A series of experiments have been carried out to investigate the effects of different concentrations of thapsigargin (0, 0.001, 0.1, and 1 μM) on the proliferation and survival of human rheumatoid arthritis synovial cells (MH7A).,The results showed that thapsigargin can block the cell proliferation in human rheumatoid ... | Since the initial description of apoptosis, a number of different forms of cell death have been described.,In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases.,Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling ... | 1 |
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, predominantly affecting joints, which is initially treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).,In RA patients with insufficient response to csDMARDs, the addition of prednisone or tocilizumab, a biological ... | To investigate the impact of disease activity, the course of the disease, its treatment over time, comorbidities and traditional risk factors on survival.,Data of the German biologics register RABBIT were used.,Cox regression was applied to investigate the impact of time-varying covariates (disease activity as measured... | 1 |
To find an association between human leukocyte antigen (HLA) class II DRB1, DRB3, DRB4, and DRB5 alleles frequencies in a sample of Iraqi patients with Guillain-Barré syndrome (GBS) and compare with a healthy control group.,We performed a cross-sectional study consisting of 30 Iraqi Arab patients with GBS attending the... | Aims.,Interleukin-37 (IL-37) is an anti-inflammatory cytokine.,This study aims to investigate the concentrations of plasma and cerebrospinal fluid (CSF) IL-37 in patients with Guillain-Barré Syndrome (GBS).,Methods.,The levels of plasma and CSF IL-37, IL-17A, IFN-γ, and TNF-α in 25 GBS patients and 20 healthy controls ... | 1 |
Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction.,We aimed to dissect the role of ACPAs in osteoclast (OC) activation and to identify key cellular mediators in this process.,Polyclonal ACPA were isolated from th... | Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the world population and is a significant cause of worldwide disability.,Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of immunologic events pre... | 1 |
Genome wide association studies have identified many disease-associated non-coding single nucleotide polymorphisms, but cannot distinguish functional SNPs (fSNPs) from others that reside incidentally within risk loci.,To address this challenge, we developed an unbiased high-throughput screen that employs type IIS enzym... | Integrating genetic data from families with highly penetrant forms of disease together with genetic data from outbred populations represents a promising strategy to uncover the complete frequency spectrum of risk alleles for complex traits such as rheumatoid arthritis (RA).,Here, we demonstrate that rare, low-frequency... | 1 |
Easily accessible biomarkers enabling the identification of those patients with multiple sclerosis (MS) who will accumulate irreversible disability in the long term are essential to guide early therapeutic decisions.,We here examine the utility of serum neurofilament light chain (sNfL) for forecasting relapse-free disa... | Abnormalities in alternative splicing (AS) are emerging as recurrent features in autoimmune diseases (AIDs).,In particular, a growing body of evidence suggests the existence of a pathogenic association between a generalized defect in splicing regulatory genes and multiple sclerosis (MS).,Moreover, several studies have ... | 1 |
Preliminary studies suggest that a modified Paleolithic diet may benefit symptoms of fatigue in progressive multiple sclerosis (MS).,However, this diet restricts the consumption of eggs, dairy, and gluten-containing grains, which may increase the risk of micronutrient deficiencies.,Therefore, we evaluated the nutrition... | The precise etiology of multiple sclerosis (MS) is unknown but epidemiologic evidence suggests this immune-mediated, neurodegenerative condition is the result of a complex interaction between genes and lifetime environmental exposures.,Diet choices are modifiable environmental factors that may influence MS disease acti... | 1 |
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with the majority of cases characterised by relapsing/remitting (RRMS) attacks of neurologic dysfunction followed by variable resolution.,Improving clinical outcomes in RRMS requires both a better understanding of the i... | Biomarkers predicting fingolimod (FTY) treatment response in relapsing-remitting multiple sclerosis (RRMS) are lacking.,Here, we performed extensive functional immunophenotyping using multiparametric flow cytometry to examine peripheral immune changes under FTY treatment and explore biomarkers of FTY treatment response... | 1 |
To estimate the incidence of type 1 diabetes in all age groups in China during 2010-13.,Population based, registry study using data from multiple independent sources.,National registration system in all 505 hospitals providing diabetes care, and communities of patients with diabetes in 13 areas across China, covering m... | Recent studies have indicated that an imbalance of gut microbiota is associated with the development of type 1 diabetes mellitus (T1DM) and there is no literature regarding it in Chinese children yet.,The aim of this study was to evaluate the alteration of gut microbiota between children with newly diagnosed T1DM and h... | 1 |
Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells in pancreatic islets that is mediated by autoimmune mechanisms.,The classic view is that autoreactive T cells mistakenly destroy healthy (‘innocent’) β-cells.,We propose an alternative view in which the β-cell is the key co... | Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of the pancreatic β-cells, a process in which autoreactive T cells play a pivotal role, and it is characterized by islet autoantibodies.,Consequent hyperglycemia is requiring lifelong insulin replacement therapy.,T1DM is caused by the interaction of... | 1 |
Changes in long noncoding RNA expression in autoimmune hepatitis (AIH) have not been studied previously.,We investigated differentially expressed long noncoding RNAs and differentially expressed mRNAs in a Con A‐induced AIH mouse model with microarray for the first time and reveal expression changes involved in the pat... | Persistent and excessive cytokine production is a hallmark of autoimmune diseases and may play a role in disease pathogenesis and amplification.,Therefore, cytokine neutralization is a useful therapeutic strategy to treat immune-mediated conditions.,MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate ge... | 1 |
To investigate the effect of 4 weeks of treatment with liraglutide on insulin dose and glycemic control in type 1 diabetic patients with and without residual β-cell function.,Ten type 1 diabetic patients with residual β-cell function (C-peptide positive) and 19 without (C-peptide negative) were studied.,All C-peptide-p... | Little is known concerning the primary cause(s) of mortality in type 1 diabetes responsible for the excess mortality seen in this population.,The Allegheny County (Pennsylvania) childhood-onset (age <18 years) type 1 diabetes registry (n = 1,075) with diagnosis from 1965 to 1979 was used to explore patterns in cause-sp... | 1 |
We aimed to find out the asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among pediatric patients with rheumatic diseases and healthy children and to compare them with each other.,Patients with familial Mediterranean fever (FMF), juvenile idiopathic arthritis (JIA), and juvenile... | Juvenile idiopathic arthritis and adult rheumatoid arthritis are two major groups with chronic joint pain and inflammation, extra-articular manifestations, and high risk of comorbidities, which can cause physical and ocular disability, as well as create great socio-economic pressure worldwide.,The pathogenesis of arthr... | 1 |
Angiogenesis is a critical process in the formation of new capillaries and a key participant in rheumatoid arthritis (RA) pathogenesis.,The chemokine (C-X-C motif) ligand 13 (CXCL13) plays important roles in several cellular functions such as infiltration, migration, and motility.,We report significantly higher levels ... | Increased extracellular Ca2+ concentrations ([Ca2+]ex) trigger activation of the NLRP3 inflammasome in monocytes through calcium-sensing receptor (CaSR).,To prevent extraosseous calcification in vivo, the serum protein fetuin-A stabilizes calcium and phosphate into 70-100 nm-sized colloidal calciprotein particles (CPPs... | 1 |
To examine the metabolic, gluco-regulatory-hormonal and inflammatory cytokine responses to large reductions in rapid-acting insulin dose administered prandially before and after intensive running exercise in male type 1 diabetes patients.,This was a single centre, randomised, controlled open label study.,Following prel... | To determine the effects of exercise order on acute glycemic responses in individuals with type 1 diabetes performing both aerobic and resistance exercise in the same session.,Twelve physically active individuals with type 1 diabetes (HbA1c 7.1 ± 1.0%) performed aerobic exercise (45 min of running at 60% V̇o2peak) befo... | 1 |
See Stankoff and Louapre (doi:10.1093/brain/awy114) for a scientific commentary on this article.,Grey matter atrophy in multiple sclerosis affects certain areas preferentially.,Eshaghi et al. use a data-driven computational model to predict the order in which regions atrophy, and use this sequence to stage patients.,At... | ‘No evidence of disease activity’ (NEDA), defined as absence of magnetic resonance imaging activity (T2 and/or gadolinium-enhanced T1 lesions), relapses and disability progression (‘NEDA-3’), is used as a comprehensive measure of treatment response in relapsing multiple sclerosis (RMS), but is weighted towards inflamma... | 1 |
Notch signaling coordinates numerous cellular processes and has been implicated in many pathological conditions, including rheumatoid arthritis (RA).,Although the role of Notch signaling in development, maturation, differentiation, and activation of lymphocytes has been comprehensively reported, less is known about its... | Rheumatoid arthritis is an autoimmune disease that causes serious functional loss in patients.,Early and accurate diagnosis of rheumatoid arthritis may attenuate its severity.,Despite a diagnosis guideline in the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification crite... | 1 |
Regulatory T cells (Treg) play a critical role in the prevention of autoimmunity, and the suppressive activity of these cells is impaired in rheumatoid arthritis (RA).,The aim of the present study was to investigate function and properties of Treg of RA patients in response to purified polysaccharide glucuronoxylomanno... | Mast cells have been implicated to play a functional role in arthritis, especially in autoantibody-positive disease.,Among the cytokines involved in rheumatoid arthritis (RA), IL-17 is an important inflammatory mediator.,Recent data suggest that the synovial mast cell is a main producer of IL-17, although T cells have ... | 1 |
To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature.,In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened.,... | The aim was to collate all myasthenia gravis (MG) epidemiological studies including AChR MG and MuSK MG specific studies.,To synthesize data on incidence rate (IR), prevalence rate (PR) and mortality rate (MR) of the condition and investigate the influence of environmental and technical factors on any trends or variati... | 1 |
Extensive gray matter (GM) involvement has been demonstrated in multiple sclerosis (MS) patients.,This study was aimed to identify GM alterations in relapsing-remitting MS (RRMS) patients using synthetic quantitative MRI (qMRI).,We assessed myelin volume fraction (MVF) in each voxel on the basis of R1 and R2 relaxation... | In multiple sclerosis (MS), demyelination and neuro-axonal loss occur in the brain grey matter (GM).,We used magnetic resonance imaging (MRI) measures of GM magnetisation transfer ratio (MTR) and volume to assess the regional localisation of reduced MTR (reflecting demyelination) and atrophy (reflecting neuro-axonal lo... | 1 |
The use of alemtuzumab, a humanized monoclonal anti-CD52 antibody has changed the therapy of highly active relapsing-remitting MS (RRMS).,Alemtuzumab infusion depletes most lymphocytes in peripheral blood, whereas differential recovery of immune cells, probably those with a less CNS-autoreactive phenotype, is supposed ... | Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS.,Therefore, it was interestingly to find that current... | 1 |
Long noncoding RNAs (lncRNAs) have recently emerged as important biological regulators, and the aberrant expression of lncRNAs has been reported in numerous diseases.,However, the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) in rheumatoid arthritis (RA) has not been well documented.,We applied a ... | Analysis of the ImmunoChip single nucleotide polymorphism (SNP) array in 2816 individuals, comprising the most common subtypes (oligoarticular and RF negative polyarticular) of juvenile idiopathic arthritis (JIA) and 13056 controls strengthens the evidence for association to three known JIA-risk loci (HLA, PTPN22 and P... | 1 |
Follicular helper T cells (Tfh) are implicated in type 1 diabetes (T1D) and their development has been linked to CD28 costimulation.,We tested whether Tfh were decreased by costimulation blockade using the CTLA-4-Ig fusion protein (Abatacept) in a mouse model of diabetes and in individuals with new onset T1D.,Unbiased ... | Epigenetics is defined as mitotically heritable changes in gene expression that do not directly alter the DNA sequence.,By implication, such epigenetic changes are non-genetically determined, although they can be affected by inherited genetic variation.,Extensive evidence indicates that autoimmune diseases including ty... | 1 |
IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide.,However, IgAN rarely affects African Blacks and is uncommon in African Americans.,Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-antigen by glycan-specific antibodies, leading to formation of circula... | The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome.,Whether it applies to individuals excluded from the original study and how... | 1 |
Mavrilimumab, a human monoclonal antibody, targets granulocyte-macrophage colony‐stimulating factor receptor α.,We undertook to determine the long‐term safety and efficacy of mavrilimumab in rheumatoid arthritis patients in 2 phase IIb studies (1071 and 1107) and in 1 open‐label extension study (ClinicalTrials.gov iden... | MicroRNA-146a (miR-146a) has been shown to play an important role in the regulation of inflammatory innate immune responses, and found to be differentially expressed in rheumatoid arthritis (RA).,Through NF-κB pathway, this molecule is able to stimulate the release of pro-inflammatory cytokines such as TNF-α, IL-1β, an... | 1 |
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