Datasets:
H2KP
/
cdip-annotations-formnet-v1

Dataset card Data Studio Files
xet
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stringlengths
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503673277_503673281-2.layout.json
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2023474185_2023474186-0.layout.json
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511781859_511781868-8.layout.json
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2044308146.layout.json
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50450842-0843-0.layout.json
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0001039501-82.layout.json
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2046807567_7643-68.layout.json
[ "18:01", "637", "1503", "PHILIP", "XORRIS", "€O", "CRS-68", "Last", "year,", "Wells", "published", "an", "updated", "apalysis", "of", "the", "12", "available", "epidemialogic", "studies", "of", "passive", "smoking", "and", "heart", "digease.’®®", "He", "estimated", "that", "passive", "smoking", "causes", "62,000", "heart", "disease", "deaths", "each", "year.", "Wells", "adopted", "the", "same", "procedures", "that", "he", "and", "his", "colleagues", "used", "in", "the", "EPA", "report", "to", "compute", "the", "number", "of", "passive", "smoking", "lung", "cancer", "deaths.", "The", "12", "epi", "studies", "were", "assigned", "a", "quality", "tier", "ranking", "of", "1", "to", "4", "and", "weighted", "according", "to", "study", "size.", "In", "addidon,", "each", "relative", "risk", "was", "corrected", "for", "confounding", "and", "adjusted", "for", "smoker", "misclassificazion", "bias.", "Wells", "caleulated", "an", "overall", "passive", "smoking", "relative", "risk", "(RR)", "of", "192,", "Whereas", "the", "EPA", "estimate", "of", "passive", "smoking", "lung", "cancer", "deaths", "used", "&", "value", "of", "Z", "=", "1.75,", "Welle", "chose", "a", "higher", "value", "of", "Z", "=", "2.6,", "based", "on", "Fontham’s", "study,", "in", "order", "to", "estimate", "the", "number", "of", "ETS-", "related", "heart", "disease", "deaths.", "The", "heart", "disease", "epi", "studies", "include", "several", "estimates", "of", "relative", "risk", "among", "never-smoking", "males.", "Wells", "reasoned", "that", "men", "are", "exposed", "to", "more", "background", "ETS", "than", "women", "and", "calculated", "a", "value", "of", "Z", "=", "2.1", "for", "the", "male", "studies.", "The", "estimate", "of", "62,000", "heart", "disease", "deaths", "attributable", "to", "passive", "smoking", "far", "exceeds", "EPA’s", "estimate", "of", "3,000", "ETS-related", "lung", "cancer", "deaths,", "even", "though", "the", "number", "of", "deaths", "attributed", "to", "active", "smoking", "is", "similar", "in", "magnitude.", "Heart", "disease", "is", "the", "leading", "canse", "of", "death", "in", "the", "United", "States.", "Almost", "half", "2", "million", "people", "die", "from", "beart", "disease", "each", "year,", "of", "which", "an", "estimated", "180,000", "deaths", "are", "attributed,", "by", "the", "public", "health", "service", "to", "smoking,", "Lung", "cancer", "is", "the", "cause", "of", "appraximately", "150,000", "deaths", "annually,", "80", "percent", "of", "which", "(120,000)", "are", "attributed", "to", "smoling.", "Thus", "the", "risk", "to", "nonsmokers", "of", "heart", "disease", "is", "much", "larger", "than", "the", "risk", "of", "lung", "cancer.", "Therefore,", "even", "though", "the", "odds", "ratios", "for", "heart", "disease", "due", "to", "BTS", "in", "the", "Wells", "study", "are", "similar", "to", "those", "used", "by", "the", "EPA", "for", "lung", "cancer,", "the", "absolute", "risk", "implied", "is", "much", "higher", "(the", "heart", "disease", "risk", "is", "a", "percentage", "of", "&", "much", "larger", "number).", "Thus,", "whereas", "EPA’s", "estimate", "of", "the", "ETS-related", "lung", "cancer", "risk", "(e,", "RR,", "=", "1.19)", "among", "never-smoking", "women", "is", "&", "small", "fraction", "(2", "percent)", "of", "the", "lung", "cancer", "risk", "among", "ever-smoking", "women", "(RR", "=", "11},", "Wells’", "estimate", "of", "the", "ETS-", "related", "heart", "disease", "risk", "is", "almost", "one-third", "of", "the", "risk", "among", "ever", "smokers", "(see", "table", "below).", "Recause", "of", "these", "relationships,", "some", "investigators", "have", "questioned", "the", "biological", "plausibility", "of", "the", "passive", "smoking", "heart", "digease", "risk", "estimates.'", "Half", "of", "the", "studies", "reported", "relative", "risks", "greater", "than", "1.7,", "the", "estimated", "heart", "disease", "risk", "ratio", "among", "ever", "smokers.", "Moreover,", "the", "passive", "smoking", "to", "active", "Uncontrolled", "Confounders.", "Comments", "o", "Docket", "Office,", "Dociet", "No,.", "H-122,", "U.S.", "Department", "of", "Labor,", "August", "1994.", "108", "Wells,", "J.A", "Pascive", "Smoking", "as", "2", "Cause", "of", "Heart", "Disease.", "J.", "Am.", "Collage", "of", "Cardiclogy,", "vol.", "24,", "mo.", "2,", "1994,", ".", "546554,", "%See", "(i)", "Huber,", "G.L.", "ot", "al.", "Passive", "168", "mEsE", "g", "X", "992.", "p.", "18.", "(ii)", "Semet", "—", "Lippman's", "boek", "Smoking", "and", "Your", "Heare.", "Consumers:", "Research,", "A", "on", "environmental", "healsh.", "DRAFT", "SUEJECT", "TO", "REVISION.", "NOT", "FOR", "QUOTATION", "OR", "ATTRIBUTION.", "@031-039", "G€92089F0%" ]
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511781859_511781868-9.layout.json
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2053441605.layout.json
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0060295853.layout.json
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508939370_508939517-118.layout.json
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ti13540617_0618-1.layout.json
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2023616141_2023616176-14.layout.json
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2051554123_2051554127-1.layout.json
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11300117-0136-8.layout.json
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13156510-3.layout.json
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524860047+-0116-38.layout.json
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506492376.layout.json
[ "@", "CONFIDENTIAL", "o", "Author:", "L.", "Cheryl", "Miller", "Date:", "June", "15,", "1987", ".Zs#=§;4&", "Group:", "Biochemical/Biobehavioral", "R&D", "Notebook", "Pages:", "N/A", "Division:", "Biobehavioral", "R&D", "Previous", "Reports:", "R&DM,", "1986,", "178", "R&DM,", "1987,", "No.96", "No.", "of", "Pages:", "6", "Program", "No.:", "0201", "Biobehavioral", "OVERVIEW", "OF", "THE", "CURRENT", "ANIMAL", "WELFARE", "ACT", "(PUBLIC", "LAW", "99-198)", "AS", "IT", "RELATES", "TO", "THE", "CARE", "AND", "USE", "OF", "LABORATORY", "ANIMALS", "OBJECTIVE:", "The", "objective", "of", "this", "memorandum", "is", "to", "provide", "an", "overview", "of", "the", "federal", "laws", "and", "policies", "regulating", "the", "use", "of", "animals", "for", "research", "purposes.", "The", "Animal", "Welfare", "Act,", "amended", "to", "its", "current", "status", "by", "Public", "|", "Law", "(P.L.)", "99-198,", "became", "effective", "on", "December", "1,", "|", "1986.", "The", "law", "contains", "provisions", "for", "the", "minimum", "care", "requirements", "and", "humane", "treatment", "of", "laboratory", "animals.", "The", "basic", "components", "of", "the", "Law", "are", "briefly", "discussed", "in", "this", "memorandum.", "SUMMARY:", "The", "basic", "provisions", "of", "the", "Animal", "Welfare", "Act", "that", "are", "especially", "relevant", "to", "research", "institutions", "and", "investigators", "are", "summarized.", "STATUS:", "The", "provisions", "of", "the", "Animal", "Welfare", "Act", "are", "being", "implemented", "into", "RJRT", "policy", "on", "the", "care", "and", "use", "of", "laboratory", "animals.", "KEYWORDS:", "\"", "Animal", "Welfare", "Act,", "Laboratory", "Animals", "9.EZ", "B6¥90S", "RJR-US", "v.", "PM,", "ET", "AL.‘" ]
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2022161585_2022161648-26.layout.json
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50630676-0676.layout.json
[ "RESEARCH", "53,", "717-72(,", "February", "13,", "1993]", "Advances", "in", "Brief", "Mutation", "in", "the", "nm23", "Gene", "Is", "Associated", "with", "Metastasis", "in", "Colorectal", "Cancer!", "Liming", "Wang,®>", "Umesh", "Patel,", "Lagnajita", "Ghosh,", "Huan-Chao", "Chen,", "and", "Sipra", "Banerjee®", "Department", "of", "Moieculur", "Biology,", "Research", "Institute,", "The", "Cleveland", "Clinic", "Foundation,", "Clevelund,", "Okio", "44195", "Abstract", "The", "human", "nm23", "gene,", "a", "candidate", "metastatic", "suppressor", "gene,", "consists", "of", "two", "gemes,", "nm23-HI", "and", "nm23-H2.", "The", "potential", "mutation", "in", "the", "gene", "was", "examined", "in", "colorectal", "cancer", "using", "a", "reverse", "tran-", "scription", "polymerase", "chain", "reaction", "amplification", "followed", "by", "DNA", "se-", "quencing", "analysis.", "Genomic", "alterations", "in", "the", "nm23", "gene", "were", "also", "exam-", "ined", "by", "Southern", "hybridization.", "Genetic", "alterations", "either", "as", "a", "deletion", "in", "the", "coding", "sequence", "of", "nm23-H1", "or", "as", "an", "alletic", "deletion", "were", "detected", "in", "four", "among", "eight", "colorectal", "adenacarcinomas", "associated", "with", "metastases", "in", "lymph", "nodes,", "lung,", "or", "liver.", "No", "alteration", "was", "observed", "in", "12", "additional", "colorectal", "cancer", "specimens", "without", "metastasis.", "These", "results", "provide", "first", "evidence", "for", "novel", "mutation", "in", "the", "nm23", "gene", "and", "demonstrate", "a", "corre-", "lation", "between", "the", "mutation", "in", "the", "nm2J3", "gene", "and", "metastasis", "in", "colorectal", "oncogenesis", "which", "suggests", "that", "the", "nm23", "gene", "plays", "2", "role", "in", "the", "causa-", "tion", "of", "metastasis.", "Introduction", "A", "cascade", "of", "cellular,", "biochemical.", "and", "genetic", "events", "are", "known", "to", "occur", "in", "the", "development", "and", "progression", "of", "tumors", "leading", "to", "ma-", "lignancy", "and", "ultimately", "to", "metastasis.", "A", "novel", "gene,", "nm23,", "a", "candidate", "metastasis", "suppressor", "gene,", "encodes", "a", "human", "M,", "17,000", "nuclear", "and", "cytoplasmic", "protein", "containing", "152", "amino", "acids", "(1,", "2).", "The", "gene", "is", "focalized", "on", "chromosome", "17q22", "(3).", "The", "human", "nm23", "gene", "family", "consists", "of", "two", "genes,", "nn23-H{", "and", "nm23-H2,", "with", "88%", "homology", "{4).", "The", "nm23", "gene", "is", "expressed", "significantly", "higher", "in", "human", "breast", "tissues", "having", "low", "metastatic", "activity", "in", "comparison", "to", "breast", "wmor", "with", "high", "metastatic", "activity", "(5,", "6}.", "Recently,", "nm23-#1", "amplification", "with", "overexpression", "in", "RNA", "has", "been", "reported", "in", "neuroblastomas", "(7).", "Interestingly,", "an", "enhanced", "level", "of", "nm23", "expression", "was", "observed", "in", "colorectal", "carcinomas", "with", "no", "relationship", "between", "the", "expression", "level", "of", "am23", "and", "metastatic", "activity", "(8).", "Recently,", "examining", "nine", "informative", "cases", "of", "colon", "cancer,", "a", "somatic", "allelic", "loss", "of", "nm23", "in", "one", "cancer", "patient", "and", "a", "homozygous", "deletion", "in", "a", "lymph", "node", "me-", "tastasis", "in", "another", "case", "has", "been", "reported,", "indicating", "that", "nm23", "is", "involved", "in", "a", "significant", "manner", "in", "tumorigenesis", "and", "metastasis", "(9).", "No", "information", "is", "available", "about", "whether", "there", "is", "a", "genetic", "alteration", "other", "than", "allelic", "change", "(for", "example,", "mutation)", "in", "the", "remaining", "seven", "cases", "of", "colon", "cancer.", "In", "an", "sttempt", "to", "determine", "the", "potential", "mutation", "in", "the", "nm23", "gene", "in", "colorectal", "oncogenesis", "and", "possible", "relation", "with", "metastasis,", "we", "amplified", "the", "entire", "nm23-H/", "coding", "region", "of", "colorectal", "tumor", "and", "corresponding", "normal", "mucosa", "by", "reverse", "transcription-polymerase", "chain", "reaction", "followed", "by", "DNA", "sequencing.", "Additionally,", "the", "so-", "matic", "allelic", "loss", "of", "nm23", "analyzed", "by", "Southern", "hybridization", "was", "also", "examined", "in", "these", "tumors.", "A", "preliminary", "study", "has", "been", "reported", "(10).", "Received", "11/17/92;", "accepted", "1i4/93.", "The", "cosis", "of", "publication", "of", "this", "article", "were", "defrayed", "in", "part", "by", "the", "payment", "of", "page", "charges.", "This", "anicle", "must", "therefore", "be", "hereby", "marked", "advertisement", "in", "accordance", "with", "18", "U.5.C.", "Section", "1734", "solely", "to", "indicate", "this", "fact.", "!", "Supported", "by", "a", "pilot", "program", "of", "the", "American", "Cancer", "Society.", "*", "Recipient", "of", "a", "fellowship", "from", "the", "Earl", "and", "Francis", "Foster", "Memoriai", "Fund.", "*To", "whom", "tequests", "for", "reprints", "should", "be", "addressed.", "717", "Materials", "and", "Methods", "Specimens.", "Surgically", "removed", "colorectal", "tumors", "and", "carresponding", "nor-", "mal", "mucosa", "were", "obtained", "from", "the", "Departments", "of", "Colorectal", "Surgery", "and", "Surgical", "Pathology,", "The", "Cleveland", "Clinic", "Foundation.", "Metastatic", "cases", "were", "identified", "by", "clinical", "and", "histopathological", "analyses", "of", "neoplastic", "cells", "in", "organs", "such", "as", "lymph", "nodes,", "liver,", "lung,", "etc.,", "along", "with", "the", "primary", "tumor,", "Normal", "colon", "mucosa", "specimens", "were", "provided", "by", "Dr.", "Claudio", "Fiocchi,", "De-", "partment", "of", "Immunalogy,", "The", "Cleveland", "Clinic", "Foundation.", "Normal", "peripheral", "blood", "samples", "were", "obtained", "from", "the", "Department", "of", "Hematology,", "The", "Cleve-", "land", "Clinic", "Foundation.", "The", "human", "placenta", "was", "a", "gift", "from", "Dr.", "A.", "W.", "Southern", "Blot", "Analysis.", "Genomic", "DNA", "from", "colorectal", "tumors", "and", "cor-", "responding", "normal", "mucosa", "was", "isolated", "as", "described", "(13).", "Twenty", "pg", "of", "DNA", "were", "completely", "digested", "with", "Bg/Il", "and", "separated", "on", "0.8%", "agarose", "gel", "and", "then", "transferred", "to", "Nitran", "membrane", "(13).", "The", "blots", "were", "hybridized", "with", "an", "a-*?P-labeled", "533-base", "pair-nm23-H1", "probe", "(entire", "coding", "sequence", "of", "normal", "colon", "mucosa", "prepared", "by", "PCR", "amplification)", "in", "standard", "conditions", "(13).", "Steggles,", "Northeastern", "Ohio", "Universities", "College", "of", "Medicine.", "Reverse", "Transcription-PCR*", "Amplification.", "Both", "0.2-0.4", "g", "tumor", "and", "corresponding", "normal", "mucosa", "were", "frozen", "and", "pulverized", "to", "powder", "in", "liquid", "nitrogen.", "Total", "RNA", "was", "isolated", "by", "the", "guanidinium", "thiocyanate-CsCl", "method", "{11},", "and", "1", "ug", "RNA", "was", "used", "for", "reverse", "transcription", "following", "the", "instruc-", "tions", "of", "the", "SuperScript", "preamplification", "system", "(Gibco/BRL,", "Bethesda,", "MD).", "First-strand", "¢DNA", "was", "directly", "used", "for", "35", "cycles", "of", "PCR", "amplification", "(12)", "using", "GeneAmp", "PCR", "reagent", "kit", "(Perkin", "Elmer", "Cetus,", "San", "Diego.", "CA).", "A", "pair", "of", "primers,", "ham23c", "5\"t", "AAGAATTCTCGGGTCGAGGCCGCCATG", "and", "hnm23", "3':", "GGGAATTCTGCGCCAGGGAGGATACAG.", "based", "on", "the", "mRNA", "sequence", "(4),", "were", "designed", "to", "amplify", "the", "entire", "nm23-H/{", "coding", "sequence", 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529191250+-1250.layout.json
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521826392+-6403-7.layout.json
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531678089+-8091-1.layout.json
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509282845+-2845.layout.json
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0060207968.layout.json
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2022161585_2022161648-35.layout.json
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0001240680-2.layout.json
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