H2KP/cdip-annotations-formnet-v1 · Datasets at Hugging Face

id stringlengths 18 46	words list	bboxes list
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"present", "their", "views", "on", "a", "major", "public", "health", "issue", "that", "is", "of", "great", "concern", "1o", "us,”", "WHO", "Director-General", "Gro", "Harlem", "Brundtland", "said.", "After", "the", "hearings,", "the", "first", "round", "of", "formal", "ncgotiations", "will", "take", "place", "among", "191", "member-nations", "from", "October", "16", "10", "21%,", "2000", "(Xinhua", "8/18).", "Greece:", "Smugglers", "Released", "On", "Bail", "On", "August", "19,", "scven", "Ukrainians", "and", "four", "Greeks", "arrested", "on", "charges", "of", "smuggling", "cigaretics", "into", "Grecee", "were", "relcased", "on", "bail.", "They", "were", "arrested", "by", "the", "Coast", "Guard", "on", "August", "20\"", "when", "their", "ship,", "the", "Scorpion,", "tried", "to", "unload", "its", "cargo", "at", "Neo", "Faliron.", "The", "police", "are", "also", "probing", "the", "possibility", "of", "a", "link", "between", "the", "bailed", "out", "persons", "and", "the", "murder", 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50640139-0139.layout.json	[ "Proc.", "Natl.", "Acad.", "Sci.", "USA", "Vol.", "90,", "pp.", "41564160,", "May", "1993", "Gene", "inoculation", "generates", "immune", "responses", "against", "human", "immunodeficiency", "virus", "type", "1", "BiN", "WanG,", "KENNETH", "E.", "UGENT,", "VASANTHA", "SRIKANTAN,", "MICHAEL", "C.", "AGADIANYANT,", "KESEN", "DaNG,", "YOSEF", "REFAELI,", "ALICE", "1.", "SaTo,", "JEAN", "BOYER,", "WILLIAM", "V.", "WILL1aMs,", "AND", "DAVID", "B.", "WEINERT#", "Institute", "of", "Biotechnology", "and", "Advanced", "Molecular", "Mcdicine", "in", "the", "Department", "of", "Medicine,", "University", "of", "Pennsylvania", "School", "of", "Medicine,", "and", "TThe", "Wistar", "Institute,", "3600", "Spruce", "Street,", "Philadelphia,", "PA", "19104", "Communicated", "by", "Robert", "Austrian,", "January", "14,", "1993", "{received", "for", "review", "October", "6,", "1992)", "ABSTRACT", "Recently,", "immunization", "techniques", "in", "which", "DNA", "cunstructs", 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0001039501-101.layout.json

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504792890_504792892-1.layout.json

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"on", "a", "major", "public", "health", "issue", "that", "is", "of", "great", "concern", "1o", "us,”", "WHO", "Director-General", "Gro", "Harlem", "Brundtland", "said.", "After", "the", "hearings,", "the", "first", "round", "of", "formal", "ncgotiations", "will", "take", "place", "among", "191", "member-nations", "from", "October", "16", "10", "21%,", "2000", "(Xinhua", "8/18).", "Greece:", "Smugglers", "Released", "On", "Bail", "On", "August", "19,", "scven", "Ukrainians", "and", "four", "Greeks", "arrested", "on", "charges", "of", "smuggling", "cigaretics", "into", "Grecee", "were", "relcased", "on", "bail.", "They", "were", "arrested", "by", "the", "Coast", "Guard", "on", "August", "20\"", "when", "their", "ship,", "the", "Scorpion,", "tried", "to", "unload", "its", "cargo", "at", "Neo", "Faliron.", "The", "police", "are", "also", "probing", "the", "possibility", "of", "a", "link", "between", "the", "bailed", "out", "persons", "and", "the", "murder", "of", "an", "Italian", "cigarette", "smuggler,", "Saverio", "Benvenuto", "on", "August", "11\"", "(Kathimerini", "8/20).", "France:", "Air", "France", "Bans", "Smoking", "Air", "France", "will", "ban", "smoking", "on", "its", "{lights", "to", "Asia,", "South", "America,", "Africa", "and", "the", "Middle", "East", "from", "November", "1st,", "2000.", "Cabin", "crews", "will", "provide", "a", "cigarette", "substitute", "to", "passengers", "“suffering", "from", "a", "lack", "of", "nicotine”", "(AFX", "Europe", "8/18).", "Italy:", "Inflation", "Rises", "In", "Italy", "According", "(o", "the", "statistics", "burcau", "ISTAT’s", "reports", "on", "August", "18\"", "Italy’s", "consumer", "prices", "including", "tobacco", "were", "up", "0.2", "percent", "in", "July", "2000", "from", "June", "2000", "and", "had", "increased", "2.6", "percent", "from", "the", "1999", "Ievel.", "In", "June", "2000,", "the", "NIC", "index", "with", "tobacco", "saw", "an", "increase", "of", "0.3", "percent", "from", "May", "2000,", "or", "a", "2.7", "percent", "increase", "on", "the", "1999", "level,", "The", "NIC", "CPI", "ex-", "tobacco", "in", "June", "2000", "was", "up", "0.4", "percent", "from", "May", "2000", "and", "was", "2.7", "percent", "more", "than", "a", "year", "earlier", "(Agence", "France", "Presse", "8/18).", "Poland:", "Rise", "In", "Cigarette", "Excise", "Tax", "According", "to", "tobacco", "wholesalers’", "estimates,", "smuggled", "foreign", "cigarettes", "could", "capture", "one-fourth", "of", "the", "Polish", "cigaretie", "market", "by", "2002", "because", "of", "another", "planned", "excise", "tax", "hike.", "In", "1999,", "smuggled", "cigarettes", "accounted", "for", "10", "percent", "of", "the", "market,", "with", "the", "country", "losing", "about", "ZL730", "million", "(US$", "LE1S", "880€S", "WAO00-34" ]

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524860047+-0116-23.layout.json

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50640139-0139.layout.json

[ "Proc.", "Natl.", "Acad.", "Sci.", "USA", "Vol.", "90,", "pp.", "41564160,", "May", "1993", "Gene", "inoculation", "generates", "immune", "responses", "against", "human", "immunodeficiency", "virus", "type", "1", "BiN", "WanG*,", "KENNETH", "E.", "UGENT,", "VASANTHA", "SRIKANTAN*,", "MICHAEL", "C.", "AGADIANYANT,", "KESEN", "DaNG*,", "YOSEF", "REFAELI*,", "ALICE", "1.", "SaTo*,", "JEAN", "BOYER*,", "WILLIAM", "V.", "WILL1aMs*,", "AND", "DAVID", "B.", "WEINER*T#", "*Institute", "of", "Biotechnology", "and", "Advanced", "Molecular", "Mcdicine", "in", "the", "Department", "of", "Medicine,", "University", "of", "Pennsylvania", "School", "of", "Medicine,", "and", "TThe", "Wistar", "Institute,", "3600", "Spruce", "Street,", "Philadelphia,", "PA", "19104", "Communicated", "by", "Robert", "Austrian,", "January", "14,", "1993", "{received", "for", "review", "October", "6,", "1992)", "ABSTRACT", "Recently,", "immunization", "techniques", "in", "which", "DNA", "cunstructs", "are", "introduced", "directly", "into", "mammalian", "tissue", "in", "vivo", "have", "been", "developed.", "In", "theory,", "gene", "inoculation", "should", "result", "in", "the", "production", "of", "antigenic", "proteins", "in", "a", "natural", "form", "in", "the", "immunized", "host.", "Here", "we", "present", "the", "use", "of", "such", "a", "technique", "for", "the", "inoculation", "of", "mice", "with", "a", "human", "immuno-", "deficiency", "virus", "type", "1", "(HIV-1)", "envelope", "DNA", "construct", "(pM160).", "Mice", "were", "injected", "intramuscularly", "with", "pM160", "and", "were", "subsequently", "analyzed", "for", "their", "anti-HIV", "envelope", "im-", "mune", "responses.", "Antisera", "collected", "from", "inoculated", "animals", "reacted", "with", "the", "recombinant", "HIV-1", "envelope", "in", "ELISA", "and", "immunoprecipitation", "assays.", "The", "antisera", "also", "contained", "an-", "that", "were", "able", "to", "neutralize", "HIV-1", "infection", "and", "inhibit", "HIV-1-mediated", "syncytium", "formation", "in", "vitro.", "Furthermore,", "splenic", "lymphocytes", "derived", "from", "pM160-inoculated", "animals", "demonstrated", "HIV-envelope-specific", "proliferative", "responses.", "The", "gene", "inoculation", "technique", "mimics", "features", "of", "vaccination", "with", "live", "attenuated", "viruses", "and,", "therefore,", "may", "ultimately", "prove", "useful", "in", "the", "rapid", "development", "of", "safe", "and", "efficacious", "vaccines", "as", "it", "provides", "for", "production", "of", "relevant", "antigen", "in", "vivo", "without", "the", "use", "of", "infectious", "agents.", "Recently,", "direct", "injection", "of", "a", "normal", "functional", "gene", "into", "a", "living", "animal", "has", "been", "shown", "to", "be", "of", "great", "promise", "for", "gene", "therapy", "(1-3).", "Direct", "inoculation", "of", "the", "gene(s}", "of", "a", "pathogen", "should", "mimic", "attenuated", "vaccines", "as", "synthesis", "of", "specific", "foreign", "proteins", "would", "be", "achieved", "in", "the", "host", "and", "would", "be", "the", "target", "of", "immune", "surveillance.", "A", "modest", "level", "of", "gene", "expression", "was", "demonstrated", "as", "the", "result", "of", "intramuscular", "injection", "of", "the", "human", "growth", "hormone", "gene", "and", "the", "human", "dystrophin", "gene", "in", "mice", "(2,", "3),", "and", "the", "gene", "product", "in", "some", "circumstances", "can", "elicit", "antibody-based", "immune", "responses", "(4).", "However,", "it", "has", "not", "been", "determined", "whether", "T-cell", "responses", "are", "elicited", "or", "whether", "relevant", "immune", "responses", "to", "a", "human", "pathogen", "can", "be", "elicited.", "The", "human", "immunodeficiency", "virus", "(HIV)", "is", "responsible", "for", "the", "AIDS", "pandemic.", "Intensive", "investigation", "of", "the", "im-", "munobiology", "of", "HIV", "has", "generated", "a", "wealth", "of", "data", "regarding", "the", "relevant", "specific", "immune", "responses", "that", "in", "vitro", "appear", "to", "correlate", "with", "virus", "inactivation", "(for", "review,", "see", "refs.", "5", "and", "6).", "Studies", "with", "simian", "immunodeficiency", "virus,", "the", "related", "primate", "retrovirus,", "have", "generated", "insight", "with", "regard", "to", "relevant", "protective", "immune", "responses", "in", "vivo", "(7-9).", "Accord-", "ingly,", "the", "HIV", "system", "is", "a", "useful", "model", "for", "the", "analysis", "of", "immune", "responses", "generated", "through", "genetic", "inoculation", "techniques.", "We", "have", "analyzed", "immune", "responses", "generated", "by", "the", "intramuscular", "injection", "of", "mice", "with", "a", "HTV-1", "envelope", "gp160", "DNA", "construct.", "We", "demonstrate", "that", "this", "DNA", "con-", "struct", "is", "capable", "of", "eliciting", "specific", "and", "neutralizing", "immune", "responses", "and", "appears", "to", "include", "the", "immiine", "responses", "desired", "in", "a", "putative", "vaccine", "for", "this", "human", "pathogen.", "The", "publication", "costs", "of", "this", "article", "were", "defrayed", "in", "part", "by", "page", "charge", "payment.", "This", "article", "must", "therefore", "be", "hereby", "marked", "*‘advertisement™", "in", "accordance", "with", "18", "U.S.C.", "§1734", "solely", "to", "indicate", "this", "fact.", "4156", "50840139", "MATERIALS", "AND", "METHODS", "Plasmid", "Construction.", "The", "envelope", "gene", "of", "the", "HIV-1", "HXB2", "isolate", "was", "cloned", "by", "polymerase", "chain", "reaction", "(PCR)", "amplification", "utilizing", "2", "A", "phage", "clone", "obtained", "from", "the", "AIDS", "Research", "and", "Reference", "Reagent", "Program", "(Rock-", "ville,", "MD;", "ref.", "10).", "The", "sequences", "of", "the", "5", "and", "3’", "primers", "are", "5'-AGGCGTCTCGAGACAGAGGAGAGCAAGAAATG-3", "(Xho", "I", "site,", "underlined)", "and", "5-TTTCCCICTAGATAAGC-", "CATCCAATCACAC-3'", "(Xba", "I", "site,", "underlined),", "respec-", "tively,", "and", "encompass", "the", "gp160,", "tat,", "and", "rev", "coding", "regions.", "PCR", "products", "were", "digested", "with", "Xho", "I", "and", "Xba", "1,", "cloned", "into", "the", "Bluescript", "plasmid", "(Stratagene),", "subcloned", "into", "the", "cukaryotic", "expression", "vector", "pMAMneoBlue", "(Clontech),", "and", "designated", "pM160.", "The", "plasmid", "DNA", "was", "purified", "by", "CsCl", "gradient", "ultracentrifugation.", "Expression", "of", "HIV", "gp160", "by", "pM160.", "Transfection", "of", "pM160", "into", "TE671", "cells", "was", "performed", "as", "described", "(11).", "Cells", "expressing", "the", "gpl60", "envelope", "protein", "were", "isolated", "by", "binding", "to", "M450", "magnetic", "beads", "(DYNAL,", "Great", "Neck,", "NY)", "that", "were", "coated", "with", "a", "mixture", "of", "anti-gp120", "monoclanal", "antibodies", "ID6,", "AD3,", "and", "AC4", "(12)", "and", "cloned.", "Expression", "of", "gp120", "and", "gp4l", "was", "determined", "by", "Western", "blot", "analysis", "of", "whole", "cell", "lysates", "of", "pM160-transfected", "cells.", "Gene", "Inoculation.", "To", "enhance", "muscle", "cell", "uptake", "of", "plas-", "mid", "DNA,", "mice", "were", "treated", "as", "described", "by", "Thomason", "and", "Booth", "(13}", "with", "modifications.", "Specifically,", "the", "quadriceps", "muscles", "of", "BALB/c", "mice", "were", "injected", "with", "100", "ul", "of", "0.5%", "bupivacaine", "hydrochloride", "and", "0.1%", "methylparaben", "in", "iso-", "tonic", "NaCl", "by", "using", "a", "27-gauge", "needle.", "Twenty-four", "hours", "after", "bupivacaine", "injection,", "100", "ug", "of", "the", "DNA", "construct", "was", "injected", "into", "the", "same", "site.", "DNA", "construct", "(100", "ug)", "was", "injected", "biweekly", "for", "a", "total", "of", "four", "inoculations.", "Recombinant", "gpl60", 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"Research", "and", "Reference", "Reagent", "Program.", "The", "peptides", "used", "in", "these", "studies", "were", "as", "follows:", "HXB2", "site", "implicated", "in", "CD4", "binding", "Abbreviations:", "HIV-1,", "human", "immunodeficiency", "virus", "type", "1;", "r,", "recombinant.", "1To", "whom", "reprint", "requests", "should", "be", "addressed", "at:", "Institute", "of", "Biotechnology", "and", "Advanced", "Molecular", "Medicine", "at", "the", "University", "og", "P&:msylvama,", "370", "Maloney,", "3600", "Spruce", "Street,", "Philadelphia,", "PA", "19104." ]

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0001039501-46.layout.json

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2022161585_2022161648-34.layout.json

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524860047+-0116-17.layout.json

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514050868+-0907-22.layout.json

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500441172+-1192-6.layout.json

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2024483543.layout.json

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0060159541-0.layout.json

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11300117-0136-15.layout.json

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2076276211.layout.json

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504732170+-2171-0.layout.json

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500692166_500692218-16.layout.json

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521513430+-3444-0.layout.json

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CTRSP-FILES018463-84.layout.json

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82834937_4954-6.layout.json

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2061682055.layout.json

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531376115+-6129-6.layout.json

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521513430+-3444-2.layout.json

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