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null From silent infection to rapid death: Why are some people more vulnerable to COVID-19?
Scientists discover genetic and immunological causes of 15 percent of life-threatening COVID-19 cases
September 25, 2020
Source: MUHC. Two studies published in Science by an international consortium of researchers provide a first answer to a crucial question: why does the individual vulnerability to COVID-19 vary so much in the population? The findings show that about 15 percent of patients who suffer from life-threatening COVID-19 have one thing in common: a defect in the activity of type I interferons (IFNs), molecules of the immune system that normally have a powerful antiviral activity. This defect is either caused by the presence of autoantibodies directed against those molecules or by genetic abnormalities that decrease their production. These findings could make it possible to detect people at risk of developing a severe form of the disease in all age groups and to better treat patients with these conditions.
“Since the start of the pandemic, we saw that certain risk factors were associated with an increased risk for severe COVID-19: being male, elderly or having other medical conditions. However, the biological reason for why some of these groups were getting severe disease was not clear. Additionally, there were patients who did not have these risk factors – notably, young people – who were getting life-threatening COVID-19. Again, the reason why was far from understood,” explains Dr. Donald Vinh, clinician scientist in the Infectious Diseases and Immunity in Global Health Program at the Research Institute of the McGill University Health Centre (RI-MUHC), who participated in both studies. “Now, we understand that the disruption of a very important immune agent, type I interferon, is the cause of some of the worst cases of COVID-19.”
The findings are the first results being published out of the COVID Human Genetic Effort, an ongoing international project spanning over 50 sequencing hubs and hundreds of hospitals around the world, including the McGill University Health Centre. This initiative is co-led by Jean-Laurent Casanova, head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University, and Helen Su, from the National Institute of Allergy and Infectious Diseases, in the United States.
Autoantibodies neutralizing type I interferons
Type I interferon is a set of 17 proteins crucial for protecting the body from viruses. Whether the proteins have been neutralized by autoantibodies or were not produced in sufficient amounts in the first place due to a faulty gene, the result is the same for a subgroup of COVID-19 patients: they struggle to fight the disease.
In the study Autoantibodies against type I IFNs in patients with life-threatening COVID-19, the scientists searched for autoantibodies against type I interferons in 987 patients hospitalized for life-threatening COVID- 19 pneumonia, 663 asymptomatic or mildly affected individuals infected with SARS-CoV-2, and 1,227 healthy controls from whom samples were collected before the COVID-19 pandemic.
They found that more than 10 percent of people who develop severe COVID-19 have misguided antibodies that attack not the virus, but the immune system itself, by blocking the action of type I interferon. These autoantibodies appear to be absent in people who developed a mild form of the disease, and they are rare in the general population.
“A striking element of this study is that these antibodies were much more present in men developing severe COVID-19, suggesting that their production could be linked to the X chromosome,” explains Dr. Vinh, who is also the director of the MUHC COVID-19 Biobank, an integral part of the Biobanque québécoise de la COVID-19, which collects biological materials and health information from COVID-19-positive people for research purposes.
The study suggests that patients with this profile may benefit from plasmapheresis (removal of the liquid portion of the blood containing white blood cells and antibodies) or other treatments that may reduce the production of these antibodies by B lymphocytes. Testing the general population for these antibodies could also help protect vulnerable individuals and may help predict, at the start of the infection, who may go on to develop severe COVID-19, allowing these people to get early antiviral treatment.
Inborn genetic errors decreasing the production of type I interferons
In the study Inborn errors of type I IFN immunity in patients with life-threatening COVID-19, the researchers genetically analyzed blood samples of 659 patients hospitalized for life-threatening COVID-19 pneumonia (14 percent of whom had died) and 534 subjects with asymptomatic or benign infection.
They discovered that at least 3.5 percent of patients with severe COVID-19 carry a specific kind of genetic mutation that diminishes their production of type I interferons. These mutations happen across 13 genes and are already known to be the cause of severe forms of influenza. Regardless of age, people with these genetic variations may be at greater risk of developing a potentially fatal form of influenza or COVID-19.
Early treatment with type 1 interferons could be a therapeutic option for these patients. These drugs have been available for more than 30 years and have no significant side effects if taken for a short period of time.
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In 2007, Barry Bonds hit his 75 6th home run, breaking Hank Aaron's all-time record for
most home runs in a Major League career. While it would be expected that such an
accomplishment would induce unending praise and adulationfor the new record-holder,
Bonds did not receive the treatment typically reserved for a beloved baseball hero. The
purpose of this thesis is to assess media representations of the 2007 home run chase in
order to shed light upon the factors which led to the mixed representations which
accompanied BOlTds ' assault on Aaron's record. Drawingfrom Roland Barthes ' concept
of myth, this thesis proposes that Bonds was portrayed in predominantly negative ways
because he was seen as failing to embody the values of baseball's mythology.
Using a qualitative content analysis of three major American newspapers, this
thesis examines portrayals of Bonds and how he was shown both to represent and oppose
elements from baseball's mythology, such as youth, and a distant, agrarian past.
Recognizing the ways in which baseball is associated with American life, the media
representations of Bonds are also evaluated to discern whether he was portrayed as
personifYing a distinctly American set of values.
The results indicate that, in media coverage of the 2007 home run chase, Bonds
was depicted as a player of many contradictions. Most commonly, Bonds' athletic ability
and career achievements were contrasted with unflattering descriptions of his character,
including discussions of his alleged use of performance-enhancing substances. However,
some coverage portrayed Bonds as embodying baseball myth. The findings contribute to
an appreciation of the importance of historical context in examining media
representations. This understanding is enhanced by an analysis of a selection of articles
on Mark McGwire 's record-breaking season in 1998, and careful consideration of, and
comparison to, the context under which Bonds performed in 2007. Findings are also
shown to support the contemporary existence of a strong American baseball mythology.
That Bonds is both condemned for failing to uphold the mythology and praised for
personifYing it suggests that the values seen as inherent to baseball continue to act as an
American cultural benchmark.
The export option will allow you to export the current search results of the entered query to a file. Different
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By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.
To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export.
The amount of items that can be exported at once is similarly restricted as the full export.
After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.
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Cast your vote now for the 14th Amendment to be displayed first in the new Rubenstein Gallery. Today’s post comes from Jessie Kratz, the Historian of the National Archives.
Why should the 14th Amendment be ranked first on any list of most important documents?
A constitutional guarantee of birthright citizenship for all, Federal protection of due process, and the mandate for equal protection under the law—each could individually be considered among the most significant legislation in U.S. history. And all three are included in just the first section of the 14th Amendment.
The amendment originated after the Civil War when Congress tried passing legislation to secure civil rights for the recently freed slaves. President Andrew Johnson repeatedly vetoed these bills because he believed individual states had the right to determine the status of freedmen without interference from the Federal government.
In order to take the issue out of Johnson’s reach, Congress chose to address civil rights with a constitutional amendment. On June 13, 1866, Congress approved a five-part amendment to the Constitution and on July 9, 1868, the 14th Amendment became law.
Section one of the amendment includes its most vital components.
First, the Citizenship Clause ensured that anyone born in the United States—regardless of race, color, or familial status—was automatically a U.S. citizen. The clause made citizenship a fixed condition, taking the issue out of the realm of politics where laws could be overturned and rights revoked. This section of the amendment safeguarded the citizenship status of African Americans after the Civil War and after the landmark Wong Kim Ark decision (1898), which affirmed the birthright citizenship of an American-born Chinese man and set the precedent for the clause to be applied to all races, became a means for other immigrant groups to stake their claims for U.S. citizenship.
Second, the Due Process Clause forbids states from taking away “life, liberty, or property without due process of law.” The clause effectively extended the protection of the Bill of Rights to states’ actions—previously it only applied only to the Federal government. This meant that state governments could not deprive people access to basic legal rights, such as a fair trial, and it provided a means to challenge state laws that deprived individuals of their constitutional rights.
The Due Process Clause was at the heart of many defining 20th-century Supreme Court decisions, such as Loving v. Virginia (1967), which deemed laws against interracial marriage unconstitutional in part because they denied liberty without due process, and Roe v. Wade (1973), which upheld a women’s right to an abortion under the right to privacy encompassed by the Due Process Clause.
Third, the Equal Protection Clause requires states to apply the law equally and prohibits them from discrimination on the basis of race, religion, national origin, or other arbitrary factors. Although it was initially a response to the Southern Black Codes, which severely restricted former slaves’ basic rights and subjected them to harsh punishments, the Equal Protection Clause was ultimately ineffective in securing rights for African Americans in the years following the Civil War.
In the 20th century, however, the Equal Protection Clause became the core instrument for challenging discriminatory laws and expanding rights for all citizens. It provided the rationale for a myriad of civil rights decisions, including the landmark Brown v. Board of Education (1954) which ended state-sponsored school segregation, and supplied the constitutional basis for the Civil Rights Acts of 1964.
More recently, the Supreme Court struck down the Defense of Marriage Act on the grounds that it violated equal protection. The constitutional promise of equal protection unquestionably played a crucial role in inspiring thousands of minorities, women, immigrants, and other groups to fight for equal rights.
While less essential than section one, the rest of 14th Amendment is not trivial. Section two eliminated the three-fifth rule, which counted slaves as three-fifths of a person for the purpose of congressional apportionment. It also guaranteed that all male citizens over the age of 21, regardless of their race, had a right to vote. The third and fourth sections provided terms for repayment of Civil War debts and rules for federal service by ex-Confederates, addressing issues that may have hindered southern states’ re-entry to the Union. The final section gave Congress the authority to enforce the amendment.
The 14th Amendment redefined American citizenship and fundamentally altered the relationship between the states and the Federal government. It continues to be at the center of national discussions about the role of government and rights of individuals.
Cast your vote now for the 14th Amendment to be displayed first in the new Rubenstein Gallery.
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Analysis of the Contribution of Motor Vehicle Fuel Taxes to Regional Original Income at the Regional Tax and Retribution Management Agency of North Sumatra for the 2015 – 2020 Period
When regional autonomy was implemented, local government had control over the region. Local government could work because of local revenue. Without the local revenue, local government could not operating their programs. The higher the local income, the more possibility the region will be prosperous. Local revenue divided by two, there are original from region local revenue and granted revenue. Local revenue is obtained from local taxes. One of the local taxes is vehicle fuel tax. The contributions of vehicle fuel tax could be influence the original from region local revenue.
Copyright (c) 2022 Murinanda Amalya Parinduri, Rahmat Daim Harahap
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
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The Feldenkrais Method supplies musicians with the missing links that allow them to make the leap from good playing to remarkable playing. These missing links are self-awareness and effective movement patterns at the instrument.
Dr Feldenkrais said that in order to do what you want to do physically, you have to understand what you’re already doing that gets in the way. He developed movement “lessons” which shine light and potency into the “blind spots” of our self-understanding. These gentle but enormously effective lessons, create new neural pathways to make everything easier. They help musicians take the pain, effort and sense of limitation out of making music.
It is said that when two martial artists of different traditions fight, the winner does not prove the superiority of his martial art, but merely the superiority of his own kung fu, or fighting ability.
Similarly, when you are on stage, the audience doesn’t care what degrees you have, who you studied with, how many hours you practice a day, or even how good your chops are. Your audience wants to be moved. They want to feel a connection with you and with the music you are presenting. How well you do reflects your ‘musical kung fu’ – your ability to perform and convey the music behind the notes.
As it turns out, we musicians have much in common with martial artists. My own vocal and instrumental technique is full of lessons I learned in my years studying tai chi, not to mention the lessons I’ve learned from the Feldenkrais Method. And did you know Moshe Feldenkrais was a Judo master? In fact, much of the method is based on Judo.
Here are just a few concepts martial artists and musicians have in common, as well as some lessons certain martial arts have to teach musicians…
I believe we become musicians because of a vision we have of what we could do – of the music we could make. We might have fallen in love with the sound of the instrument as played by a teacher or on a recording, or we might have been drawn to the simple idea of being a musician. This vision, whatever it is, sustains us through those difficult first steps of learning to make a sound – any sound at all at first, and then a (let’s face it) tolerable sound, and eventually, we hope, a sound which we find satisfying. As we master our art, our sense of what’s possible evolves, the vision evolves, and we can always see a ‘next step’ for our skill.
What’s preventing you right now from realizing your vision? What’s preventing you from reaching your next step?
Injury? Tension? Posture? Anxiety? A lack of flow and ease? Lack of inspiration, of connection to the vision, to the music itself?
All of these impediments to your art are bound up in your most basic habitual movement patterns: from the habits you use to hold yourself up and move around, to those you use to interact with other people, to the very patterns you use to make music….
If you’re Jewish, and you take the High Holidays seriously, you might have had the experience that, as the Days of Awe progress, you’re just beginning to touch something, just beginning to see and feel your life for what it really is, just beginning to realize what it is that you need to do to really turn over a new leaf in the new year… and… then it’s all over. the final shofar blows, and … you feel lighter! The Holidays have worked their magic once again.
But what of that glimpse? What was that possibility of redemption? Of transformation? Of some fundamental shift in your relationship to the way you inhabit your life?
And what does this have to do with Awareness Through Movement?
Every summer now for over a decade I have had the great pleasure and honor of spending a few weeks teaching Feldenkrais at the beautiful World Fellowship Center at the foot of the White Mountains near Conway, New Hampshire. I spend the first half of my stay teaching, coaching, and performing at the Early Music Week, and the other half teaching a four-day intensive Awareness Through Movement retreat.
The casual observer might get the impression that I am advocating a way of being and acting that includes no commitment to goals or to improvement, a sort of anything-goes / take it easy / do whatever you like / it’s all good / whatever comes naturally philosophy with no sense of purpose or forward momentum.
Nothing could be further from the truth. What I am talking about here is the approach that allowed me to make my own impossible possible: to recover from chronic hand pain which for years made me feel like I would never be able to play my instrument again. It took me close to a decade of patient commitment to transform myself from a lost, confused, and pretty-much disabled recent college grad, to a serious student of movement, then a serious student of music, and finally a professional musician and Feldenkrais teacher. Many times I was tempted to give up, or just grit my teeth and push through (which, I quickly realized again and again, would amount to pretty much the same thing), but I am now very glad I kept with it.
Many students say to me at their first private Functional Integration lesson something like “I know I need to strengthen my core.” (This is almost as common as “I know I have bad posture”). Sometimes they refer to their own experience, telling me that they feel weak, or that they tire easily, but more often their personal experience is simply that their back or neck hurts, and they heard from someone (often a skilled Physical Therapist or yoga teacher) that the pain in their back is due to weak “core” muscles.
When I help them feel what they’re actually doing, it usually turns out that they’re tightening those “core” abdominal muscles all the time. No wonder they feel weak! If a muscle is always engaged, it has less strength to engage further – its potential is already in use.
I have always felt a connection between Jewish spirituality and the Feldenkrais method. Maybe this is because Moshe Feldenkrais was Jewish (he spent his childhood in a traditional community in Europe, and came from a line of important Hasidic rabbis). Or maybe it’s because I discovered the Feldenkrais Method and Jewish spirituality at about the same time. Over the past few years I have felt both this connection and some tensions between the approaches most keenly around the High Holidays. This is hardly surprising, since on a certain level Yom Kippur and the Feldenkrais method seek to do the same thing: to provide a space for change in our habitual ways of living.
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Dr. Dara Salcedo
I am originally from Mexico City were I grew up and eventually got my Bachelor's degree in Chemistry. When I started college, I had many questions about molecules, reactions, colors, substances, and I thought that everything was going to be answered in my classes. Soon, I realized that every time a question was answered, three or four new questions arose! By the time I got my degree, I knew that doing science to answer questions is a never ending story, but it is fun, so I went to Cambridge, MA to get my PhD. I chose the field of Atmospheric Chemistry because it is about applying Chemistry to understand the environment. Also, I like to think that the research I do will be useful for policy makers to generate new laws that will protect our health and environment. Now, I live in Cuernavaca, a city south from Mexico City, which is called "the city of the eternal spring" because it has a very mild weather and you can always find a tree blooming!
During MILAGRO, I will be at T0 measuring particles. The objective is to learn about their chemical and physical properties and to deduce their history (where they were emitted and how they were transformed once in the atmosphere). I could not do the latter without the help of other colleagues measuring gases, temperature, wind, etc. That is what it is important about the MILAGRO project: every research group is doing a different measurement; when all the measurements are put together will be able to understand air pollution better (like pieces of a puzzle that form a landscape when put together).
When I am not doing science, I enjoy to be at home, cooking, hiking and going to the movies. I also like traveling with my husband and we use every opportunity we have. This photo was taken last year in Sidney, Australia. Next April, we are going to visit some caves in Central Mexico (a well deserved trip after all the hard work in March during MILAGRO).
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Menasseh Ben Israel
Rabbi of Amsterdam
Series: Jewish Lives
- ISBN: 9780300224108
- Published By: Yale University Press
- Published: August 2018
Steven Nadler’s monograph, Menasseh ben Israel: Rabbi of Amsterdam, provides an excellent introduction to a rabbi whose fascinating life as a first-rate scholar, diplomat, and theologian warrants examination. Written in an engaging narrative style, Nadler brings out aspects of Menasseh’s career not mentioned in the only other English biography on Menasseh, Cecil Roth’s A Life of Menasseh ben Israel: Rabbi, Printer, and Diplomat (Jewish Publication Society, 1934). For example, the violence between Menasseh’s father and his first wife in Lisbon (9) is brought to the English reader for the first time. As such, this book represents a long overdue reappraisal of the life of one who “for much of the seventeenth century, [was] the most famous Jew in the world” (4).
One of the book’s strengths is that Nadler analyzes the full range of Menasseh’s interactions with gentiles. Indeed, he does not focus solely on the philo-Semites but also on anti-Semites such as Gisbertus Voetius (47). Moreover, Nadler is highly conversant with the political and theological forces at work, notably with his references to the impact of the Arminian-Calvinist controversy in the Dutch Reformed Church upon Menasseh (30-33). Indeed, Nadler’s strong grasp of the Dutch Second Reformation is clear throughout and he contrasts the tensions within the Dutch Church with the pioneering nature of Menasseh’s “ecumenical efforts and conciliatory attitude toward Christian doctrines” (3).
By devoting a whole chapter to the Conciliador, Nadler rightly emphasizes the importance of Menasseh’s three-volume compendium of reconciliations to perceived Bible inconsistencies. Nadler offers little analysis of the text in detail, but as the Conciliador runs to over 600 pages such an analysis would merit another book entirely. Published in 1632, 1641, and 1651, Nadler notes how the third volume reflects the influence of Menasseh’s conversations with Millenarians upon his thoughts as Messianic themes are more prominent (146) in the final section. This observation reflects the fact that Jewish-Christian relations are rightly central to Nadler’s historiography: he effectively contextualizes Menasseh within a small Jewish community surrounded by Christians.
Similarly, the chapter devoted to The Hope of Israel (1650) makes a brief allusion to Menasseh’s famous treatise of Messianic hope which he dedicated to the English Parliament, before proceeding to chart Menasseh’s time in England between 1655 and 1657. As such, this serves as a great introduction to Menasseh as a diplomat.
Additionally, Nadler revisits an old debate by advocating a revisionist approach to the role and genuineness of the intentions of philo-Semites in the period. Nadler documents Menasseh’s relations with John Dury, Nathaniel Homes, Samuel Hartlib, Henry Jessey, and Thomas Throwgood in detail yet concludes that it is “very misleading” (136) to label them “philo-Semites.” Such a view will surely draw a response from scholars who may see Nadler as critical of the Dutch and English Millenarians who gave the Jews relative peace in Holland and advocated the same in England ahead of the Whitehall Conference in 1656 and Cromwell’s unofficial readmission of the Jews. Indeed, while Nadler demonstrates a strong grasp of the currents of thought prevalent within the Arminian-Calvinist debate in Holland, and fits Menasseh within the backdrop of a community battling between orthodoxy and heterodoxy with Spinoza soon to arrive on the scene, he fails to explore the eschatological beliefs of these Millenarians and shows little evidence of understanding the distinctive nature of their beliefs, for example, that the Jews have not been replaced by the Church and that Israel will be the preeminent nation during the Millennium.
Furthermore, at times Nadler has a rather uncritical approach to his sources and often relies on secondary literature to substantiate his historical claims. For example, he writes that Menasseh, when he was in England in 1655-56, “even dined with Cromwell at his home” (208), yet this is only supported in the endnotes by a reference to Thomas Pococke’s translation of De Termino Vitae, The Term of Life, which dates from 1700 and gives no references for this event. Similarly, Nadler refers to Menasseh meeting “the Cambridge philosopher Ralph Cudworth” and the reports supported by Popkin and Katz that Menasseh “angered Cudworth by giving him some Jewish anti-Christian literature” (209). Nadler engages with Popkin’s claims in his endnote, stating that Popkin “provides no evidence for these reports, and it would seem to have been both an impudent thing to do and contrary to Menasseh’s character” (265). However, that such critical engagement with existing scholarship is relegated to the endnotes is disappointing for a scholarly work.
Nadler makes a significant and well-reasoned contribution to the field in his Appendix in which he reassesses claims that there was a deep friendship between Menasseh and Rembrandt. Nadler unmasks these myths, even those proposed by scholars who pioneered studies on Menasseh ben Israel, such as Cecil Roth, who wrote of “the affection which existed between him [Rembrandt] and the Jewish rabbi” (A Life of Menasseh ben Israel: Rabbi, Printer, and Diplomat, 169). Nadler paints such an engaging picture of the “tolerant and cosmopolitan atmosphere of seventeenth-century Holland” (222) that it is only natural that we opine a friendship between Rembrandt and Menasseh, although Nadler correctly points out that no conclusive evidence can be given to support this.
Overall, Nadler’s argument that Menasseh was both a bridge-builder to the Christian community and divisive within the Jewish community is carefully substantiated. The book’s success is the way in which it arouses the reader’s interest to explore Menasseh’s writings. Moreover, it is a rich summary of important aspects of intellectual history during a fascinating period and constitutes the perfect introduction for anyone unacquainted with this endearing Dutch rabbi. Additionally, Nadler illustrates that religious history can be written in a literary style that pulls the reader in and is far from just dry and technical. For this Nadler is to be highly commended.
Lawrence Rabone is a doctoral student in Jewish/Christian Studies at the University of Manchester.Lawrence RaboneDate Of Review:January 5, 2019
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As it is early in the year, I thought it would be interesting to start delineating some inclusion strategies in chronological order, in terms of an employer’s relationship with an employee. Recruitment marks the beginning of every relationship between employer and employee, think of the first accidental glance across a room exchanged with someone who later becomes a friend. Employers are recruiting all of the time without being aware of it: manufacturers are recruiting every time they advertise their products; non-profits are recruiting when they ask people to donate or volunteer for their cause, and governments are recruiting when they send their employees out to serve the public. If people like what they see or hear or taste or use they may think about joining those who helped to create their positive experience.
Word of Mouth
Many employers give their employees a financial reward if they refer someone who is hired by the company. Employee referrals are highly valued, especially in the for-profit sector as the data is impressive in terms of employee retention rates for employee referral new hires. Governments have much lower turn-over rates than the private and non-profit sectors, but increasingly are modeling their management styles on the private sector, including paying bonuses to high performing employees and terminating those who do not meet the standards established for their function. This means that government employers are also paying more attention to recruiting high-potential employees. The greatest source of information about an organization is its employees. If they are unhappy, they let people outside of the organization know. There is a great website, glassdoor (www.glassdoor.com), which posts anonymous employee ratings of employers. Savvy job hunters go there before applying for jobs. People who have left companies telling their exit interviewer, “I have a better opportunity elsewhere,” tend to be more honest with their friends and on websites such as glassdoor. Employers would be well advised to visit this and other sites to find out what people are saying about them, and more importantly, to use that information to improve their employee relations.
We, in the diversity field used to worry that employee referrals limited the diversity of new hires, but not anymore. Well, not if you already have some diversity. “Diverse” employees (people of color, LGBT employees, people with disabilities, etal) will refer employees like themselves, just as white, male, heterosexual employees will do. Sometimes, employees will refer candidates who are not from their affinity group, but people primarily refer candidates who are similar to themselves. So, the more diverse your employees are, the more diverse their candidate referrals will be. This will also have a positive impact on your employee retention rates as the ‘diverse’ new hires will have an easier time adapting to an organizational culture that is diverse not only in its representation, but also in its innovation. Employers that are intentionally inclusive get real bonuses as they get the attention of ‘high potential candidates’.
Inclusive Recruitment is NOT Affirmative Action!
Inclusive recruitment welcomes stellar employees – regardless of their affinity group affiliation. Talented people come in all races, nationalities, ethnic groups, orientations and abilities. So, if you want to hire ambitious, highly talented people, invite them intentionallyto contribute to your organization. There has been a great deal of buzz (not to be confused with buzz words) regarding “Saturday Night Live” (SNL) and the lack of diversity among the actors on the show. SNL’s management responded to a great deal of negative press regarding the stark absence of diversity at the season’s kick off by hiring Sasheer Zamata, an African-American woman. This process took about three months and is the first time in six years that there will be an African American woman on the SNL cast, which is interesting considering that Lorne Michaels, the top executive on the show said in an October interview with The Associated Press, “It’s not like it’s not a priority for us, it [hiring black women], will happen. I’m sure it will happen.” The announcement this week that Ms. Zamata was joining the cast has been met with a flurry of comments on both sides of the diversity debate. I have been thinking about how much pressure she will experience as those who are cynical of the process of creating an inclusive workforce think of her as an ‘affirmative action hire’. If she is not incredibly entertaining and hilarious during every single skit that she is in, she will be vilified by those skeptics. The writers of the skits, the director, the other actors, will not be subject to the same scrutiny. Ms. Zamata’s qualifications and expertise in her field will not be held up as evidence for hiring her. She will have to rise above the haters and their words and remember – just like all of the other cast members at SNL – she has managed to beat the odds and get selected to be on show. Many employers talk about how creating a diverse workforce is a priority, but few take intentional, strategic action to make it happen.
The Good News
The good news is that any organization, regardless of their history in terms of recruitment can become an inclusive recruiting organization! A great first step is conducting an anonymous employee survey. Many employers are reluctant to do this for two reasons: 1. They may not like what they hear (and this makes those in the legal department very nervous). 2. They may not feel ready to implement the changes that employees recommend. The executive team of your organization would be wise to honestly and openly discuss the possibility of improving your organizational inclusion by doing some real assessment of your current workforce. If you are satisfied with your employees’ performance and engagement and diversity and retention and development and succession – KUDOS! If not, isn’t it about time that you do make it a priority?
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I recently came across this lovely short film called ”Mical”. It’s based on the true story of dyslexia experts Pat and Mike Jones, and it does a wonderful job documenting their “pits and peaches” as we say around here.
In these past 10 years at Sterne, I have heard this same story from countless prospective families: their children feel ashamed, frustrated, even enraged, when they don’t learn in the same way or at the same pace as their peers; their teachers became their enemies instead of steady and reliable allies; their parents struggle to understand them or their needs, and often that anxiety and worry reaches multiple boiling points at school and at home. I wish this story weren’t so common, but I do know that Sterne’s reading and writing intervention methods--some of which are actually highlighted in this film!--can help students break through learning challenges. Our teachers, whose attitudes and skills are reflected beautifully through the eyes of Pat Jones in this film, can change students’ lives and sense of self worth.
Please take some time to view this short, award winning film at home. I’ve included a few family discussion questions below to help frame what could be an important conversation around the dinner table tonight.
1. What’s Michael’s experience in school like? Can you relate to this, and if so, how?
2. Michael’s father, Peter, says that he’s “slow”. Is this true? What indications do we have throughout the film that Michael is, in fact, intelligent?
3. Is Michael naturally “violent” or “out of control” as the Principal suggests?
4. How do Michael’s mom and dad respond, early in the film, to his challenges? How does this change?
5. Why is Michael’s mother able to teach him how to read when others schools have failed him?
6. Parents: Can you relate to any of the feelings that Pat and Peter express throughout the film? What has changed? What has stayed the same?
- learning support
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CC-MAIN-2022-33
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MIL is one of the highest restaurants in the world.
Driving through the town of Maras, in the Cusco region of Peru, the air is heavy with salt, as if a chalky filter has been placed over the landscape: the ochre hills, the narrow roads abutting houses with blue doors and crumbling edges, and the local women with their colourful jackets and famous bowler hats. Just outside of town, toward the Urubamba River and the Sacred Valley of the Incas, there are thousands of open-air salt evaporation pools, in operation since the time of the Incas.
Leaving Maras, the air clears and the indigo silhouettes of the Andes relate the scale of the region—including its altitude; it becomes harder to breathe as the trail winds up to Moray. Moray is a site that has baffled archaeologists for decades. One theory suggests that the massive concentric circles cut deep into the mountaintop were terraces, the difference in elevation and sunlight allowing crops from a variety of different environments to grow. Whatever the rationale for building it, Moray resonates with ingenuity; and MIL, which overlooks the ancient stonework, follows suit.
MIL, the brainchild of famed Lima chef Virgilio Martínez, is not flashy from the outside. Its thatched roof and mud brick siding almost blend into the tawny hills. But inside, MIL comes to life, and visitors soon realize that it is more than just a restaurant. A sloping hallway decked with a variety of drying plants—hinting at the heterogeneous agricultural ethic of the establishment—leads to an open-air courtyard. Around this are glass walls that allow a look into the dining room, the tasting room, and Mater Iniciativa, the research arm.
The name MIL (pronounced “meal”, the same as Spanish for a thousand) is fitting. The restaurant is 3,500 metres above sea level, and it utilizes some of the over 4,000 different species of potato native to Peru. The focus on this wide array of agriculture pays homage to Moray, but also to the ingenuity of Andean farmers, a culture that the operators of the restaurant try to preserve at every culinary turn.
In the Mater Iniciativa office, staff are hard at work researching ways to bring varieties of crops to local farmers so that MIL can source a huge variety of Peruvian foods while also helping the communities it is neighbour to. This mission makes sitting down for a meal at MIL so much more satisfying. Luis Valderrama’s kitchen offers dishes that highlight the unique culinary mission of the establishment, presented in a decidedly modern way.
Courses with names like “Plateau” feature cabuya nectar, lamb, kañihua grain, and white quinoa. Unbelievably coloured potatoes are served in massive stone vessels topped with edible chaco clay, and many of the spirits are infused on-site with local plants and herbs. Careful with the booze here, though—the altitude makes it go straight to your head.
Ambience and lack of oxygen inspire a state of reflection for those in the space. Small windows cut into the mud brick offer views of the mountains beyond, and servers offer diners alpaca blankets to keep away the mountain chill.
Cocoa, in different concentrations, is available raw in the small gift shop selling local goods. MIL prides itself on processing cocoa into the restaurant’s very own chocolate. The 90 per cent cocoa is bitter but enlivening, giving the body a boost to beat the altitude.
While extreme, the experience of visiting and eating at MIL restaurant in Peru is not only trendy, but an accomplishment. Its model of sustainable, regionally conscious cuisine is an inspiration and a treat.
Never miss a story. Sign up for NUVO’s weekly newsletter here.
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This information was adapted from Addressing Emotional Needs While You're Sick: Guidance for Individuals (PDF) from the Michigan Department of Health and Human Services, 04/30/2020.
If you are experiencing illness during the COVID-19 outbreak, you may find that you feel worried about your health, your family, and the symptoms you are having. You are not alone. This page addresses some common signs of stress, along with ways to lessen them.
Know that in these circumstances it is normal to experience some fear and worry. The stress from the illness you are experiencing can trigger distress reactions. Take note of how you are feeling emotionally.
Here are some distress reactions to look out for:
- Insomnia – difficulty falling or staying asleep
- Anxiety and feeling afraid
- Feeling unsafe
- Feeling angry
- Placing blame on others for your illness or stress
During times of overwhelming stress, one may start to use unhealthy coping skills, thus making feelings of anxiety and fear worse.
Monitor yourself for the following stress reactions:
- Changes in intake of food, alcohol, tobacco, or other substances
- Feeling no balance between school or work and life - withdrawing from your family/friends or feeling like you cannot manage your work or academic commitments
- Feeling very isolated and alone
- Family or social conflicts
If you are experiencing these types of stress reactions and are worried that you are not able to cope, or find yourself relying on unhealthy and risky behaviors, please reach out to your healthcare provider right away. If you are experiencing severe stress, having feelings or actions of violence or suicide seek immediate emergency medical attention. Please reach out to your healthcare provider for guidance about your health, concerns about your illness, and mental health services.
While you are recovering from your illness:
- It is normal to feel the way you do during increased times of stress. Many people are feeling this way, and you are not alone.
- Try to recognize your own distress reactions and behaviors. You may want to keep a journal or write down these behaviors as you notice them.
- Reach out for help early if you feel like you are becoming too stressed to take care of yourself or are using risky behaviors to cope. There are people ready and able to help you through this challenging time.
- Create a routine – find low-impact, accessible things you can do every day to help you feel engaged. Have compassion for yourself and your limitations.
- Follow instructions provided by your healthcare provider.
Strategies to reduce worry:
- Identify a support network – call when you feel overwhelmed or need to talk to someone about your experience.
- Take daily media breaks – it can be overwhelming and focuses on the negative.
- Identify other stressors to put on hold while you recover (such as daily work).
- Refocus on positive thoughts - think of things that are good, and that you are grateful for.
- Practice calming strategies - try mindfulness, meditation or step outside, even for just a few minutes.
Remember you are not alone.
U-M students may contact a campus resource:
- University Health Service:
- Dean of Students Office
- Student Emergency Funds
- U-M International Center
- Counseling and Psychological Services
For U-M faculty and staff:
- Faculty and Staff Counseling and Consultation Office
- Michigan Medicine Office of Counseling and Workplace Resilience
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CC-MAIN-2022-33
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https://uhs.umich.edu/addressing-emotional-needs-while-sick-COVID
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| 0.938541
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The Franchising Centre founder Brian Duckett talks to US brand Mathnasium, as they prepare to take a children’s franchise to the UK market
Over the years, The Franchising Centre has enabled dozens of franchisors to expand internationally, either into or out of the UK and beyond. Whilst the challenges faced by franchisors often have common elements, the fast-growing ‘children’s sector’ is often seen as a simpler audience to serve as there are fewer cultural issues regarding tastes and styles. Kids are kids the world over, aren’t they?
Well, apparently things are not always as they seem. This month I had the opportunity to sit down with Steve Felmingham, UK Operations Director for Mathnasium – the children’s maths learning centre franchise. Mathnasium started in the USA and are now in 15 countries and growing, so I thought Steve might be able to shed some light on the challenges they faced as they entered each new market.
BD: I can see that Mathnasium have been franchising for 16 years but are relatively new to the UK – why the long period before entering the UK market? Surely the UK would have been the first logical step outside the US, given that we have a common language already and so translation would have been so much less of an issue?
SF: I think someone once said that the UK and the US are two nations separated by a common language! There are certain market sectors where differences in spelling, grammar and terminology wouldn’t be an issue, but children’s education isn’t one of them. Our customer base is parents who are worried that their children might be falling behind in school, and they need to know that we are going to be able to identify and plug any gaps in their knowledge and understanding. Our system of teaching is identical the world over. It never changes but the ‘packaging’ of our offering differs in every country.
Clearly we need to understand the educational landscape but also if we are to engage with parents and their children we need to resonate with them in every interaction, be that marketing materials, programme materials, online adverts or any other customer-facing content. One thing we learned very quickly is that the British consumer is far more aware of this than virtually any other market we’ve entered, hence the delay in getting ourselves ready to enter this market.
BD: Sounds like somebody had a big job getting Mathnasium ready for the UK then! Why do you feel that the UK is so much more aware of these little differences?
SF: I believe that nearly every country has a product or service which they feel they ‘own’; something which they feel nobody can do better than them. For example in Italy that might be coffee, in Germany that might be engineering and in the UK, that is almost certainly education. If you imagine going up to a British parent and saying we have an American education system for them, good as it is, they might naturally feel some reluctance because it is not home-grown.
BD: So how did you mitigate that risk?
SF: This is where the localisation of our entire programme came in. It took us two years at a cost of over $1.7m, but we ended up with a programme which is a perfect match to the UK educational landscape, and resonates with parents – and indeed franchisees – in this country as well as it does in every other.
BD: You mentioned franchisees – did the franchise offering need to be adapted as well?
SF: Yes, almost as much as the educational programme. We are a bricks and mortar business, operating from prominent High Street retail premises. In the US that’s usually a case of picking a location in a strip mall, agreeing terms with the landlord and setting up shop. Here in the UK we have things like planning consents to deal with, and the financial model needs to include things like business rates and VAT.
BD: What would you say is the biggest challenge from a franchisee’s point-of-view?
SF: Undoubtedly the acquisition of property. Because our usage is not conventional retail, our franchisees invariably need to obtain ‘Change of Use’ on the premises they lease, and that causes delays and difficulties on all sides. Frustratingly, many landlords – and a surprising number of town planning officers – haven’t realised that the retail landscape is changing and insist on hanging on to the outdated notion that premises kept as retail will be easier to let. Our model – which is a subscription-based membership model – is actually far more robust than the conventional retail model of buying stock and displaying it in the hope that someone will come along and buy it. Our business model cannot be replicated online, will never go out of fashion, and actually draws new people into an area on a very regular and repeatable basis.
BD: So you wouldn’t say that the children’s sector is a particularly easy one to export then?
SF: No, but I would say that it is a hugely dynamic and growing sector, so it is well worth the effort!
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<urn:uuid:d07ab82c-b46c-4d71-857a-875dc848604e>
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CC-MAIN-2022-33
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Here is a compilation of top photo editing apps that will come in handy in a designer’s life.
In this fast emerging tech world, it is really important for designers and developers to effortlessly handle tasks quickly like developing app prototype or editing any image.
Whether it’s a mockup or poster, editing graphics is just like applying finishing touches to any painting. It is important to ensure that whatever you create would look aesthetically pleasing, having the right color, filter, and frame in order to fit in with the rest of your client’s visual feeds.
Now imagine this scenario: you are asked to make certain editing to a particular
Forget the hassle, think photo editing apps!
While designing is still complicated like before, photo editing apps have made the designer’s life easier. They have eliminated the need of sitting in front of your personal computer when making even the slightest changes.
With this photo editing app, all you need to do is open it in your smartphone and make the required changes with a touch on the screen. This way, you can accomplish tasks on the go.
However, the market is flooded with an array of photo editing apps and choosing the right design app can be confusing and time-consuming as well.
No need to panic as we have handpicked some best photo editing apps every designer must use.
This powerful editing app from Adobe is a simple yet sophisticated solution for editing, capturing and sharing your photos. What makes this app stand out of the rest?
Firstly, it is a simple application capable of serving both novices and pros. Secondly, the app comes with five preset modes to improve tone, contrast, exposure and color.
Other amazing features are watermarking, RAW photo support and flawless editing.
The basic version of this app is free to download. With a paid version of $10 a month, you get extra features like perspective correction and selective adjustments. Besides, you can access your photos across all your devices.
Snapseed is counted among one of the most reliable apps available. Fun fact for those unacquainted, Snapseed is actually the brainchild of Google.
The app is loaded with essential editing features like adding text, cropping, turning and straightening, as well as over 20 filters to choose from.
Control Point Technology is the major USP of Snapseed! It automatically creates attractive masks to minimize editing requirements. All you need to do is tap over the image to set a control point. Then, drag the finger within the editing circle to choose and modify the image.
Download Snapseed for iOS or Android
We have listed VSCO to this list because of its features given below:
- Enabling edit with new summer presets
- Emulating film with advanced presets
- Transforming videos with mobile editing
For this purpose(s), VSCO stands out as one of the all-time favorite photography apps. The app has easy-to-use editing tools and social features letting you connect with other designers or photographers. You can adjust each of its filters for contrast, saturation
Afterlight 2 is dubbed as a complete photo editing app thanks to its natural filters and effective editing tools that help in editing images with ease.
Furthermore, you can create your own filters using Fusions feature provided by the app. Besides that, one can pinch zoom into the image while fine-tuning the microscopic details.
Last but not the least—the app lets you choose the frames or background image of your choice.
Download Afterlight Express for iOSor Android
Another powerful image editing app on our list as it accepts files as large as 100 megapixels.
Pixelmator is an iOS app that aids your photo editing job on the go. You can sync it with all iOS devices like Mac, iPad
Pixelmator can be integrated with Adobe Photoshop. For example, you can import the images between the app for
GIMP stands for GNU Image Manipulation Program and is an open source program. It is compatible with all OS platforms including Windows, OS and Linux.
Generally, it is a wonderful app for black and white conversions. It lets you convert color images to black and white, along with basic color curves, layer masks and more. Fashion designers can see more benefits with this app as they can give their social media posts an appealing touch.
It is a mini version of Adobe Photoshop. Photoshop Express is a great photo editing app for creating photo collages, making it a must-have for social media marketers. It lets you explain your photo with digital stickers before saving and posting directly on Facebook or Instagram.
However, there is a trade-off as the app accepts only the file smaller than 16 MP.
Download Photoshop Express for iOS or Android
So these are some wonderful photo editing apps that let you do the work on the go. Again, choose the one which can go well with your requirements. Otherwise, it would be a waste of money and efforts as well if the app can do little to help.
Have you used any of above mentioned designing apps? Or are you looking for another designing app or app prototyping tool? Do we think the list should have more app or skipped some important one? Please let us know by commenting below.
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<urn:uuid:f4daa691-92b3-482d-bf4d-9bcf01b6a2a2>
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CC-MAIN-2022-33
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https://www.savahapp.com/blog/7-photo-editing-apps-for-designers
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[Bell Historians] bell pit
zen16073 at _sQILdvrqu-qrON3ynEqx30KcsRuEtwqW5MwOT7vqBFNkQZKXsIKAbK7CKRzhN3q251eM7YctBa7Ew.yahoo.invalid
Thu Jan 21 13:55:26 GMT 2010
I've been in touch with Tim Reynolds (the DAC Archaeologist) who doesn't
think it's a bell pit at all, but says that some of the locals are fixed on
the idea - to the extent of ignoring other arguments and possibilities!.
Apparently the pit is not bell shaped, it is not very deep, and on the
evidence of the primary fill is probably C18/C19th rather than C14th. He
thinks (subject to analysis) that the metal is lead
Possibly more to follow - but that probably ends the interest in this find
for most of us on this list
I wonder if the churchwardens' accounts have any reference to re-leading the
roof at that time.
More information about the Bell-historians
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<urn:uuid:fde45564-4fd7-4328-b05a-6a059aeadeea>
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CC-MAIN-2022-33
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https://lists.ringingworld.co.uk/pipermail/bell-historians/2010-January/016388.html
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Clinicians have long identified the psychological impacts and objective burdens on family members and caregivers who support loved ones with psychiatric conditions. However, there is a lack of programming available to support families with relatives who have been diagnosed with a personality disorder, and research in this area is scant. The current pilot study evaluated the impact of providing a peer-led education group for loved ones of individuals diagnosed with borderline personality disorder (BPD). A mixed-methods study design was implemented: quantitative self-report scales were used to derive scores of mastery and burden and focus groups gathered qualitative narratives. Data were collected from participants (N = 15) before and after the group intervention, as well as 4 months later. Quantitative results indicated that while participants initially reported a sense of burden in their caregiving role, their self-report of this phenomenon reduced over time following engagement with the group. The focus groups revealed that participants found the group had a positive impact on their well-being as a result of the information, skills acquisition, and support/validation they received. They also noted clinical improvements for their relatives with BPD. This study provides preliminary evidence for the effectiveness of the peer-led education group in supporting families. The results suggest that particular variables such as peer leadership, skills-based learning, and focus on caregiver wellness—rather than on the person with a diagnosis – may explain improved outcomes of this family intervention.
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<urn:uuid:d4dc46fb-c34a-4b2a-bf75-7ff23879b059>
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CC-MAIN-2022-33
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https://wels.open.ac.uk/research-project/caren/node/6477
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Louisiana oil companies suffered a major setback last week in their effort to restrict lawsuits brought by property owners seeking cleanup of land and groundwater contamination left behind from decades of drilling operations. With hundreds of millions in environmental cleanup costs at stake, neither side is pulling any punches in the fight surrounding “legacy lawsuits,” which has now spilled into the state legislature (see links to my previous related posts at bottom).
The Louisiana oil and gas industry and its government allies are attempting to negate contractual obligations to clean up oilfield contamination at sites across the state by pushing through legislation that would inhibit landowner suits. To sway legislators (and anybody else who will listen), the oil companies have long argued – and hailed a favorable report from LSU – that legacy lawsuits will deny Louisiana tens of thousands of industry jobs.
Not so fast. According to a noted economist, the LSU report is utter “nonsense” – an enormously damaging revelation that has significantly weakened the position of the oil companies in this increasingly contentious legislative fight.
Consider this from an April 19 Advocate report by Mark Ballard:
An Oregon economist told legislators Monday that a report by an LSU professor on which the oil and gas industry has relied to support its arguments for restricting lawsuits over old oilfield damage is riddled with “rookie errors.”
W. Ed Whitelaw, a professor of economics at the University of Oregon, said the widely quoted analysis omitted relevant facts, including any mention of two hurricanes.
David Dismukes, an LSU professor who works for the LSU Center for Energy Studies, released an analysis in February that found that during the past eight years, Louisiana missed out on more than 30,000 oil and gas jobs and support positions because of what are called “legacy lawsuits.”
Professor Whitelaw meticulously picked apart Professor Dismukes report in compelling and dramatic fashion during last week’s legislative hearing. Whitelaw effectively gutted the report, completely undermining the industry’s argument and embarrassing Dismukes as the author of the report. More from the Advocate report:
“Legacy lawsuits are strongly and negatively correlated with Louisiana drilling activity,” Dismukes’ report says. “Increases in legacy lawsuits are correlated with reductions in conventional Louisiana oil and gas drilling.”
Whitelaw, founder of ECONorthwest, a Portland, Ore., company that provides financial analysis for businesses and governments, said Dismukes’ widely quoted analysis has several major flaws.
“Understand that these errors, and there are three or four big ones, any one of which is enough to render his analysis nonsense,” Whitelaw said. “These are rookie errors.”
For instance, Whitelaw said, the analysis omits a relevant variable. Dismukes included data from 2005 and 2006, when the Louisiana energy industry was battered by two hurricanes, and stops his analysis in 2007.
“He fails to mention Hurricane Katrina or Hurricane Rita anywhere in the report,” Whitelaw said.
“In our opinion, the Dismukes document fails to meet any of these professional standards. And this failure matters to the degree that the Dismukes document is fatally flawed, both theoretically and empirically. Nowhere does Dr. Dismukes present a coherent economic model linking legacy lawsuits and decisions to drill in Louisiana,” the ECONorthwest report states.
Ouch! This is industry junk science at its worst. This kind of drivel would never be admissible in court.
You can bet Professor Dismukes and his friends in the industry are licking their wounds and scrambling to regain their footing.
Stay tuned. We’ll be keeping an eye on the legislative actions taking place in the coming weeks. The fireworks have just begun.
Read the Advocate report here: http://theadvocate.com/home/2590200-125/economist-hits-legacy-report
Read my April 19 post on an egregious conflict of interest in the “legacy lawsuit” legislative battle: https://www.stuarthsmith.com/louisiana-lawmakers-financial-ties-to-oil-industry-expose-stunning-conflict-of-interest-in-legacy-lawsuit-battle
Read my April 17 post detailing how Louisiana’s largest oil producer, Hilcorp, is trying to shirk its contractual obligation to clean up contamination in Erath Oil Field: https://www.stuarthsmith.com/not-so-fine-print-louisianas-largest-oil-producer-tramples-on-contractual-obligation-to-clean-up-toxic-waste
© Smith Stag, LLC 2012 – All Rights Reserved
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MANITOULIN—Two schools on Manitoulin Island will be learning how to grow and raise fish to be planted in local waters, thanks to the efforts of the Gore Bay Fish and Game Club (GBFGC).
Members the GBFGC collected eggs from adult female salmon at the Kagawong River last week. Club members helped put together and dropped off just under 200 Chinook salmon eggs to both Central Manitoulin Public School in Mindemoya and Charles C. McLean Public School in Gore Bay to raise in micro-hatcheries this winter.
“The students at both schools will feed and raise the fish eggs, which will hopefully hatch out in December,” said Ian Anderson of the GBDFGC. “And then the students will continue to raise the fish until the spring, when they will then release them back into the river.”
Mr. Anderson, along with Ches Witty, Ken Clark and Bob Mullis, took part in collecting the salmon eggs and setting up the micro-hatchery’s for the schools.
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UBC Theses and Dissertations
Novel direct redox fuel cell : membraneless low precious metal catalyst electrode assembly Dara, Mohammad Saad
The direct fuel redox fuel cell (DFRFC) substitutes the oxygen reduction cathode of low temperature fuel cells such as polymer electrolyte membrane fuel cells (PEMFC) and direct methanol fuel cells (DMFC) with an iron redox cathode of a redox flow battery. This approach helps address many of the issues with low temperature fuel cells. For both the PEMFC and DMFC the iron redox cathode eliminates precious metal content from the cathode. With respect to the PEMFC the inherent liquid nature of the iron redox cathode provides both heat and water management to the system which significantly reduces the balance-of-plant components. On the other hand, the issues of fuel crossover for the DMFC are no longer a concern as methanol is not electrochemically active at the carbon cathode used for the ferric reduction reaction. However, the use of metal redox ions in conjunction with a membrane of the same polarity introduces issues of membrane contamination which significantly reduce membrane conductivity resulting in increased ohmic overpotentials and losses in fuel cell performance. In addition, crossover of the redox catholyte can result in anode depolarization. In this a work a novel membraneless direct liquid redox fuel cell is demonstrated. The membraneless design utilizes 3-D electrode(s), the engineering of which allows control of the reactant concentration gradients. This control of the reactant gradient allows for more complete reactant utilization which mitigate catholyte crossover and allow for the elimination of the PEM. The PEM in the DFRFC used in this work is replaced with an open-spacer and liquid acid electrolyte. In addition, this novel membraneless electrode assembly design is completely scalable and flexible to different platforms, fuels, oxidants and electrolytes. In this work a membraneless direct hydrogen redox fuel cell and membraneless direct methanol redox fuel cell based on the 3-D electrode concept and controlled concentration gradient are demonstrated. In addition, the use of the liquid acid electrolyte in the membraneless direct hydrogen redox fuel cell allowed for improved ionic conductivity to the anode catalyst layer. This allowed for significant reductions in precious metal catalyst content to be made from the hydrogen oxidation anode.
Item Citations and Data
Attribution-NonCommercial-NoDerivs 3.0 Unported
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Faculty Candidate Seminar
Progressive Automated Formal Verification of Hardware and Software Systems
This event is free and open to the publicAdd to Google Calendar
Modern computing systems are increasing in complexity, making it challenging to ensure their correctness. Despite this, verification is often conducted late in development using empirical testing. This results in bugs being missed, while those that are discovered are found late in development – when the opportunities for fixing them may be limited.
Automated formal verification can provide strong correctness guarantees based on mathematical proofs, but presents a number of challenges. The models used in such verification may be far removed from real implementations, and they may have trouble scaling to the size of real-world systems. In addition, their correctness guarantees may not cover all possible programs.
In this talk, I will discuss how my PhD research has addressed each of these challenges for the verification of Memory Consistency Model (MCM) properties in parallel systems. MCMs specify the ordering and visibility rules for memory operations in parallel programs, so MCM verification is critical to parallel system correctness. My MCM verification work spans the hardware/software stack, and the tools I have developed are designed to be employed at different points in the design timeline. Together, they provide “Progressive Automated Formal Verification”, or automated formal verification throughout the system development process. My MCM work has discovered bugs in a “proven-correct” compiler mapping for C/C++11 atomics, the draft RISC-V ISA’s memory model, a commercial compiler, a lazy coherence protocol, and an open-source processor.
I will conclude with my plans for future work, which include developing new methodologies and tools for the principled design and verification of emerging heterogeneous parallel hardware, applying progressive verification to distributed and cyber-physical systems, and automating the generation of formal hardware specifications.
Bio: Yatin Manerkar is a final-year PhD candidate in the Princeton Computer Science department, advised by Prof. Margaret Martonosi. He holds a BASc in Computer Engineering from the University of Waterloo and an M.S. in Computer Science and Engineering from the University of Michigan. He also worked full-time at Qualcomm Research for one year. Yatin’s research develops automated formal methodologies and tools for the design and verification of computing systems. His work has been recognised with two best paper nominations, and three of his papers have been honoured for their high potential impact as either Top Picks or Honorable Mentions in IEEE Micro’s annual “Top Picks” issue. Yatin is a recipient of the Wallace Memorial Fellowship, one of Princeton’s highest graduate honours awarded to approximately 25 PhD students annually for a senior year of their doctoral studies. He also received the 2019 Award for Excellence from Princeton’s School of Engineering and Applied Science.
11:30-Noon: Grad Student Round Table with the Candidate, 3725 Beyster
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Sun spots, age spots, liver spots, solar lentigo, actinic keratoses, solar keratoses, seborrheoic keratoses, skin tags and sun damage
All forms of pigmentation, including melasma (hormonal pigmentation) and individual spot treatments
Face, neck, chest (décolletage), shoulders, back, arms, hands, legs
0 – 14 days, depending on device used and area treated
Some pigment spots and areas are more difficult or prone to long recovery. Moles (naevi) are deeper pigment spots. Sunspots on the legs can be very stubborn and prone to long recovery.
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https://skinresus.com.au/treatments/sun-spot-age-spot-removal/
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I have several questions regarding a RNA-seq analysis project.
My experimental design is as follows. I have 3 genotypes. Each genotype was inoculated with pathogens. Tissue were collected at 0 day as control and 3 day as test. Each experiment has 3 biological replicates. And each sample was sequence on two lanes lane5 and lane6.
The naming system I used is (genotype)(biological replicate)(inoculation)_(lane). For example, genotype Col-0 collected at 0 day was sequenced on lane5 and lane6 to produce file C10_L5 and C10_L6. Genotype Col-0 collected at 3 day was sequenced on lane5 and lane6 to produce file C13_L5 and C13_L6. This is the first biological replicate. So the other two are C20_L5, C20_L6, C23_L5, C23_L6 and C30_L5, C30_L6, C33_L5, C33_L6.
The colData from the DESeq data set looks like this.
DataFrame with 36 rows and 8 columns folders center machine lane genotype inoculation bioReplicates <factor> <factor> <factor> <factor> <factor> <factor> <factor> C10_L5 C10_L5 BGI-WH Hiseq 4000 Lane 5 Col-0 0d 1 C10_L6 C10_L6 BGI-WH Hiseq 4000 Lane 6 Col-0 0d 1 C13_L5 C13_L5 BGI-WH Hiseq 4000 Lane 5 Col-0 3d 1 C13_L6 C13_L6 BGI-WH Hiseq 4000 Lane 6 Col-0 3d 1 C20_L5 C20_L5 BGI-WH Hiseq 4000 Lane 5 Col-0 0d 2 ... ... ... ... ... ... ... ... F23_L6 F23_L6 BGI-WH Hiseq 4000 Lane 6 2R3R.F1 3d 2 F30_L5 F30_L5 BGI-WH Hiseq 4000 Lane 5 2R3R.F1 0d 3 F30_L6 F30_L6 BGI-WH Hiseq 4000 Lane 6 2R3R.F1 0d 3 F33_L5 F33_L5 BGI-WH Hiseq 4000 Lane 5 2R3R.F1 3d 3 F33_L6 F33_L6 BGI-WH Hiseq 4000 Lane 6 2R3R.F1 3d 3
I used Salmon to quantify the transcripts. I used the default setting of tximport and the output was generated "using counts and average transcript lengths from tximport". I know TPM is recommended for abundance estimate and comparing across samples and batches. Which TPM import option should I use considering my dataset? I vaguely understand the explanations here https://support.bioconductor.org/p/84883/. But which one should I choose? In other words, what different situations are these different options suited for?
From the distant plot, the data from lane5 and lane6 of each sample always cluster together. I guess the batch effect is minimal? I read the DESeq2 work flow. https://www.bioconductor.org/help/workflows/rnaseqGene/#removing-hidden-batch-effects How can I visualized the difference batch effect correction made in my analysis (DE genes)? Is there a more elaborative instruction somewhere including visualization?
The DESeq2 design I used is
design = ~ genotype + inoculation + genotype:inoculation
Should I include the batch (two lanes) in the model? Or should I just use the sva package and add in the surrogate variables?
Finally, I'm really interested in the interaction term. I want to know the inoculation specific changes in different genotype. I would appreciate if you could share some good papers (RNA-seq studies) with similar design and use the interaction term to explore the underling biology.
Thank you very much!
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What does melanoma look like in a mole?
Melanoma borders tend to be uneven and may have scalloped or notched edges, while common moles tend to have smoother, more even borders. C is for Color. Multiple colors are a warning sign. While benign moles are usually a single shade of brown, a melanoma may have different shades of brown, tan or black.
How can you tell the difference between a mole and melanoma?
The ABCDE checklist should help you tell the difference between a normal mole and a melanoma:
- Asymmetrical – melanomas usually have 2 very different halves and are an irregular shape.
- Border – melanomas usually have a notched or ragged border.
- Colours – melanomas will usually be a mix of 2 or more colours.
What does signs of melanoma look like?
Spread of pigment from the border of a spot into surrounding skin. Redness or a new swelling beyond the border of the mole. Change in sensation, such as itchiness, tenderness, or pain. Change in the surface of a mole – scaliness, oozing, bleeding, or the appearance of a lump or bump.
What are the four early warning signs of melanoma?
The “ABCDE” rule is helpful in remembering the warning signs of melanoma:
- Asymmetry. The shape of one-half of the mole does not match the other.
- Border. The edges are ragged, notched, uneven, or blurred.
- Color. Shades of black, brown, and tan may be present. …
- Diameter. …
Is a melanoma raised or flat?
The most common type of melanoma usually appears as a flat or barely raised lesion with irregular edges and different colours. Fifty per cent of these melanomas occur in preexisting moles.
What does Stage 1 melanoma look like?
Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs.
Can you have melanoma for years and not know?
How long can you have melanoma and not know it? It depends on the type of melanoma. For example, nodular melanoma grows rapidly over a matter of weeks, while a radial melanoma can slowly spread over the span of a decade. Like a cavity, a melanoma may grow for years before producing any significant symptoms.
How long does it take for melanoma to spread?
Melanoma can grow very quickly. It can become life-threatening in as little as 6 weeks and, if untreated, it can spread to other parts of the body. Melanoma can appear on skin not normally exposed to the sun. Nodular melanoma is a highly dangerous form of melanoma that looks different from common melanomas.
What does a suspicious mole look like?
Border that is irregular: The edges of suspicious moles are ragged, notched or blurred in outline, while healthy moles tend to have more even borders. The pigment of the mole may also spread into the surrounding skin. Color that is uneven: The mole may have various colors present, including black, brown and tan.
Does melanoma show up in blood work?
Blood tests. Blood tests aren’t used to diagnose melanoma, but some tests may be done before or during treatment, especially for more advanced melanomas. Doctors often test blood for levels of a substance called lactate dehydrogenase (LDH) before treatment.
What can be mistaken for melanoma?
To better illustrate the appearance of mimics, we’ll present six photographs of common skin conditions that have been mistaken for melanoma.
- Solar Lentigo. These are more commonly known as age or liver spots. …
- Seborrheic Keratosis. …
- Blue Nevus. …
- Dermatofibroma. …
- Keratoacanthoma. …
- Pyrogenic Granuloma.
What percentage of biopsied moles are cancerous?
Lab testing showed that more than 90 percent of biopsied moles were completely removed by using the single procedure, with 11 (7 percent) diagnosed as melanoma, one of the most aggressive forms of skin cancer.
Can melanoma appear overnight?
Melanomas may appear suddenly and without warning. They are found most frequently on the face and neck, upper back and legs, but can occur anywhere on the body.
How long can you live with melanoma untreated?
Survival for all stages of melanoma
almost all people (almost 100%) will survive their melanoma for 1 year or more after they are diagnosed. around 90 out of every 100 people (around 90%) will survive their melanoma for 5 years or more after diagnosis.
Do melanomas itch?
Some melanomas itch. The “E” in the ABCDE rule of melanoma is for “Evolving,” which means that something about the mole changes. New itching or tenderness falls under “Evolving.” So does a change in the size, shape, color or elevation of the mole. A melanoma may also begin to bleed or crust over.
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Glassware Plays a Pivotal Role in Research
Every laboratories in Research must be equipped with Quality glassware.
Reinheldt Glassware products are tested and proven, withstanding Heat resistance with highest transparency,contaminant and chemical resistance upon prolong use.
Glassware has variety of Types based upon usage and size of laboratory.
Please contact is for your varied and specific need of glassware, however below are some of the commonly used glassware in laboratory.
Bulb and graduated pipettes.
Burette, Glass Water Distillation Apparatus,
Funnels, Beakers, Screw Neck Laboratory Bottle with Cap, Borosilicate, Volumetric Flasks,
Graduated Cylinders, Vacuum Filtration Unit, Vials, Retorts, slides and many more…
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https://reinheldtgmbh.de/glassware/
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The Norfolk terrier is a peppy pup that matures to a pocket-sized pet, making it one of the smallest AKC-recognized working terriers. Standing just about 10 inches tall and weighing only about 12 pounds, these dogs are highly praised for their portability and permanent puppy-like appearance.
This small terrier is very closely related to the Norwich terrier, but you can tell the two apart by the distinct dropped ears of the Norfolk terrier when compared to the upright ears of the Norwich. Like most terriers, the Norfolk terrier has an alert personality and plenty of energy. They’re a great choice for individuals or families looking for a small dog breed that still has a lot of get up and go!
9 to 10 inches
Short double coat with wiry appearance
Can be red, wheaten, black and tan, or grizzle (a combination of darker and lighter hairs)
12 to 13 years
Characteristics of the Norfolk Terrier
|Tendency to Bark||Medium|
|Amount of Shedding||Low|
History of the Norfolk Terrier
The Norfolk terrier originates from Britain, specifically Norfolk county as the breed’s name suggests. The similarity in appearance to the Norwich terrier is no coincidence; both breeds were considered one and the same for many years. The Norwich terrier, as the breed was known, included two ear varieties: upright and folded.
Throughout Britain, plenty of terriers existed to hunt small game like foxes and vermin throughout the 17th and 18th centuries, but none were as small as the Norwich terrier. In the early 1900’s, a man named Frank Jones, a notable English huntsman and dog breeder, began developing a smaller but tenacious terrier that would prove to be an excellent hunting dog for rats or for bolting foxes from dens. In addition to being small enough to efficiently hunt small game or enter tight fox holes, the petite size of these terriers allowed them to be easily carried on horseback before being released for the hunt.
It’s believed that the breed descended from a combination of terriers already on the scene, like the Glen of Imaal terrier, Cairn terrier, and the Border terrier. The latter also shares a laidback personality that compares to the more mellow attitude of the Norwich, when compared with the typical terrier type.
For decades, the upright and folded ear varieties of the Norwich terrier existed as a single breed but it was a frequent subject for debate. In 1964, England’s Kennel Club recognized the Norfolk terrier with its folded ears as a separate breed. Other national breed registries followed suit, including the Canadian Kennel Club in 1977 and the American Kennel Club in 1979.
Today, the Norfolk terrier has largely found a niche as a companion pet and a show ring darling. The bright expression and lively movements often win a judge's attention, as was seen at the 2018 Westminster Kennel Club show where a Norfolk terrier won the Terrier group.
Norfolk Terrier Care
One look at the Norfolk terrier and you might think that training and care will be similar to any other toy-sized breed, but you’d be mistaken. While these dogs are similar in size to some of the most popular companion breeds, the Norfolk terrier isn’t your typical lap dog and will need plenty of stimulation.
This breed is affectionate and will enjoy regular attention, but it also has a strong ‘go’ drive. In fact, their enthusiasm and energy gave them the reputation of being a “perfect demon in the field.” Needless to say, this means that they’ll need adequate exercise and energy to be a good companion in the house. A solid walk each day, along with plenty of playtime, will keep this spirited canine happy and healthy.
The good news is that the breed is also known for being adaptable. Norfolks that are part of an active household will rise to meet any occasion, while one raised in a more laidback and calm environment will have less energy—particularly once the dog has matured. Of course, each dog’s personality will also have an impact on how much exercise and activity he or she needs to be happy and healthy.
Norfolk terriers are generally responsive to clear, positive training techniques. They do have a stubborn streak, but this can be overcome with consistency and patience. They respond well to positive reinforcement and variety in their training routine.
Norfolk terriers are known for making excellent companions for children. Their playful nature and affectionate demeanor makes them ideal pets. In addition, the small but sturdy Norfolk won’t easily topple over a child, but is also robust enough to romp and play.
While terriers can sometimes be territorial in nature, keep in mind that this dog breed was bred to hunt in a pack. As a result, they generally do well with other dogs. However, they’re not generally recommended for homes with ‘pocket pets’—like hamsters or gerbils—since these small creatures can trigger the Norfolk’s prey drive.
Grooming the Norfolk is a big consideration. For the best appearance, the double coat should be hand stripped several times a year. This removes the dull, coarse hairs and keeps the coat soft and shiny. You can also just opt for a standard clipping, but you’ll lose some of the luster and silky feel of the Norfolk’s coat. A regular brushing and occasional bath will also help to maintain your dog’s appearance in between grooming appointments.
Common Health Problems
The Norfolk terrier is a relatively hearty breed that enjoys a lifespan between 12 and 13 years, though many owners report that their dogs live to 15 years or more. However, the National Breed Club recommends that you search out a breeder that can provide clear test results for health problems common to the breed.
Common health concerns include:
Diet and Nutrition
The Norfolk terrier doesn’t require any special considerations when it comes to diet and nutrition. However, it is important to choose a quality dog food that is appropriate for your small dog’s stage of life—puppyhood, adult, or senior.
The persistent nature of the Norfolk might mean that they pester you for extra treats or to sample your human food, but beware of overfeeding this compact canine to avoid obesity.
Affectionate and friendly demeanor
Adaptable; travels well
Generally gets along with other dogs
Prey drive can be triggered by small animals
May exhibit stubbornness
Requires specific grooming techniques
Where to Adopt or Buy a Norfolk Terrier
The Norfolk terrier has a lot to offer, but there are relatively few litters born and registered each year when compared to some of the most popular AKC dog breeds. This means you’ll need to be patient if you have heart set on a puppy from a quality breeder.
However, consider opening your heart to a rescue. While organizations specifically dedicated to the Norfolk terrier are harder to find, it’s worth searching in your area for a terrier rescue or checking with local shelters.
- Norfolk Terrier Club Rescue Contacts
- Rescue Me Norfolk Terrier Directory
- American Kennel Club Breeder Listing
More Dog Breeds and Further Research
The Norfolk terrier is a unique dog breed that might be just right for your situation, if you understand the breed and what it needs. Be sure to do your research to determine if the Norfolk terrier is right for you.
Also read up on these related terrier breeds:
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When we are a parent, one of the highlights of our relationship with our child is when he / she says his / her first word. After having pronounced the first precious “daddy” and “mommy”, the child gradually learns to build his vocabulary. Parents and instructors then play a key role in this area.
Book Part or All of Your Next Adventure
Helping people all over the world learn about travel. Book Your Vacation!
Indeed, studies have shown that language proficiency is associated with several positive factors like happiness, friendship, family ties, academic success and a fulfilling professional career. But above all, having a rich vocabulary from an early age allows children to communicate very quickly with those around them and quickly build their own little world.
You should know that from birth to 2 years, a child learns on average 5,200 words. Then, in the third and fourth years of the child, his vocabulary is closely linked to his understanding of things, especially of what he reads. Here are 7 methods you can apply now to help your child in his linguistic discovery.
One of the activities that should not be overlooked as a parent is reading books to your child. Indeed, books offer an extraordinary opportunity for children to develop not only their vocabulary but also their imagination, and this method is effective from their first year.
Moreover, reading of a book also offers parents and children the opportunity to spend a special time together and, thus, to create links. You can then also chat with your child about the pictures, the story, the characters and their favorite stories.
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https://allshapes.net/7-methods-to-develop-your-childs-vocabulary/
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Start learning French at home before coming to France for an immersive stay at school
The online courses are designed for you, beginner students or students with a more advanced level of French, who wish to learn or improve your language level before your arrival at the school and/or after your departure from Montpellier.
For this purpose, several formulas are proposed to you.
The 6 levels of the CEFR* are available on the platform:
- A1: 6 Course Modules
- A2: 9 Course Modules
- B1: 9 Course Modules
- B2: 12 Course Modules
- C1-C2: 12 Course Modules
Alone or with a qualified IEF teacher, you will learn French as you wish:
- Group lessons by videoconference with an IEF teacher and unlimited access to the school’s e-learning platform.
- Individual lessons by videoconference with an IEF teacher and unlimited access to the school’s e-learning platform.
- Unlimited access to the e-learning platform (Exercises and lessons) with coaching by an IEF teacher.
Choose from one of our three offers and let us guide you:
- You will receive your login details to connect.
- You follow a tutorial to familiarize yourself with the platform.
- You take a written online French test to determine your level.
- You receive your personalised programme based on your needs.
- You are ready to start studying.
|Online Group Courses
Learn French with 5 to 8 students
|1-to-1 Online Courses
Learn French alone with your teacher
Access the e-Learning platform
|Up to 10 weeks||From 10 courses||Up to 1 year access|
|Unlimited access to the platform
|Online One-to-One Courses
For levels A1 to C2 to progress in oral and written comprehension, grammar, vocabulary…
|Videoconference group courses
French courses for students of the same level.
Exercises just for you, corrected by your teacher!
|Prices||From 150€ per week||500€ for 10 lessons||from 12,5€ per month|
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Software required for the proper functioning of the site
In order for you to have an optimal version of the site and courses, we invite you to use :
- A web browser that respects web standards such as Firefox, Safari or Google Chrome…
- A videoconferencing system (usually your computer is already equipped) including :
- headphones or another system for listening to sound – videos and mp3 files
- a microphone
- a camera (but it is not mandatory!)
- And of course have a good Internet connection (ADSL – 512kb/s) to make videoconferences!
- Our courses can also be consulted on most digital tablets, such as the Ipad for example, although it is preferable to connect via a computer for optimal viewing.
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Pram buying tips
9 things to consider when purchasing a pram or stroller
- What are your needs? Single, double, triple, side-by-side, a full travel system, travel pram, jogger, toddler conversion kit? So many options – and if you’re not sure what any of these mean see our easy-to-understand glossary at Prampedia
- What are your lifestyle requirements? Are you an active outdoorsy person that likes going to the beach, walking off the beaten the track? Or are you the urban city dweller who hops on and off public transport? Do you have to carry your pram up stairs or travel a lot? These are all questions you need to answer before you make your purchase.
- Check the size and weight: Collapsing a pram and carrying it up flights of stairs, and lifting it into the car boot can be back breakers. When looking at prams to buy practice collapsing and lifting it before making a decision. Ask the store if you can try fitting it into the boot of your car. Some full-size prams can detach the seat from the frame making it lighter and more compact but it also means putting it back together at the other end.
- What is your budget? Have a budget in mind and stick to it. Often you will find better deals online, however, you can miss out on the store-shopping bonus of negotiating with the seller to throw in some extras (e.g. shopping basket, sun cover, tyre pump, nappy bag, cup holder). And remember there are some great less expensive prams that can do as much if not more than the expensive brands. Shop for your needs rather than brand.
- Will you be using your pram to travel? A regular full-size pram can be too bulky and heavy for travel. An umbrella stroller is ideal for travel and public transport. Look for one that comes with a carry bag as this keeps it intact when checking it on planes, buses etc. The umbrella pram is also perfect for leaving in the boot of the car for those quick supermarket visits – they fit down the isles and shopping checkouts easier than your full size pram. If you’re planning a lot of walking on holiday or beach activity you may also want to consider a compact buggy that can handle the terrain and also has layback sleeping positions.
- Do you require multiple seating? If you are having your first child you may want to consider the options of whether the pram you choose has the capability of adding a toddler seat or converting to a double configuration. There are some very ingenious prams on the market that start off as a single pram and with the addition of a conversion kit, transform into a double.
- Do you need an adjustable handle? If you have differing heights in pram pushers, especially on the taller side then it is a good idea to try out models that have adjustable handle heights. Some prams have longer handles than others so make sure you find one right for all the pushers, or at least the primary pusher.
- What accessories are important to you? There’s a whole host of extras for prams like a toddler board, cup holder, extra storage, foot muff, sun cover, the ability to change the pram’s look by switching fabrics.
- Do you want a pram+car seat all in one? This is called a “travel system” and can be a great all-in-one pram to have from birth, as you can take the infant carrier straight from the car and click it onto the chassis without disturbing baby and vice-versa.
Pram safety tips – Read these before buying or using a pram or stroller
- It should meet Australian standards: Look for a label saying the model meets the (voluntary) Australian Standard (AS 2088) for prams and strollers. This is one of the most important safety tips as you do not want a product that does not meet these high standards.
- Safety harnesses: Make sure the baby pram and stroller provides a five-point harness, which also comes with shoulder straps apart from the waist and leg belts (this is essential for jogging strollers). Safety tips like these will come in handy when it comes to security.
- Steady and stable: Baby prams and strollers should be stable enough for a smooth ride. A wide-wheel base prevents a pram and stroller from tipping.
- Avoid hooking heavy bags over the handles: This is a common cause of “tip-over” injuries. Many safety tips may seem like common sense, like this one, but many parents simply forget.
- Parent safety strap: This feature secures the parent to the baby pram and stroller and adds to keeping your child secure as you push him/her along.
- Seats with complete recline for newborns: Remember to buy a baby pram and stroller offering full recline seat for infants up to three months.
- Wheel brakes: A baby pram and stroller with locking wheel brakes is essential. Using these safety tips can ensure the pram doesn’t get away on uneven ground.
- Rear-facing positions possible: Baby prams and strollers with reversible seating positions (i.e. face the front or back) provide versatility for bub.
- Parts with locking capacity: A baby pram and stroller with locking capability of moving parts prevents inadvertent folding or collapsing. Following safety tips like this one will make sure that nothing gets pinched or smashed in the pram.
- Parts in good condition: This is particularly important when purchasing a pre-loved pram –make a thorough check to rule out missing parts or signs of wear and tear.
- Detachable and washable fabrics: A baby pram and stroller with the removable and washable fabric feature goes a long way in keeping your baby safe from infections and keeping bub’s ride clean.
By using these safety tips, you will be able to make sure that your baby is safe, secure and happy whilst in the pram.
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What does officially recognized Cannabis Mean for Emergency Rooms?
Posted in Health
Weed is easily the most often abused substance in the usa. The debate over whether marijuana must be legalized is heating up. This post is not supposed to begin a talk on weed legalization. Alternatively, we want to concern a stern warning to medical professionals whose consumers test optimistic for Cannabis. People who personal-medicate or improper use Hashish (Hachís) must not be given restricted prescription drugs since cannabis consumption remains prohibited under federal rules.
In the United States, Marijuana is probably the most often abused medication. The case over whether or not to legalize Cannabis is getting hot. This item will not be designed to spark a discussion over health care weed. Sadly, many medical professionals are often up against the choice of whether or not to provide constrained prescription drugs to weed-good men and women.
Marijuana that does not help you get great
As a result component of Cannabis has little, if any, euphoric attributes, the removal in the vegetation materials known as CBD (which means cannabidiol) may be the least contentious. Marijuana has about 100 active ingredients. THC is the molecule in charge of the high related to marijuana use.
People do declare a variety of CBD advantages, starting from sleeplessness reduction, anxiousness reduction, spasticity alleviation, and pain alleviation to the treating of possibly serious conditions like epilepsy. Dravet symptoms is a kind of juvenile epilepsy that may be nearly hard to handle.
Health-related marijuana’s software
In america, medicinal marijuana is most commonly accustomed to deal with ache. Although Marijuana will not be powerful enough to deal with intensive soreness, it really is pretty useful when you are healing chronic discomfort, which influences lots of people, notably since they become more mature.
Its destination is a result of the point that it can be plainly healthier than opiates (it is difficult to overdose on and much less addicting) and that it may be employed instead of NSAIDs like Advil or Aleve if folks are not able to ingest them owing to renal, ulcer, or GERD issues.
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Defending Juveniles Accused of Sex Offenses
- Juveniles Charged With Sex Offenses: Our Approach
- Sex Offender Treatment for Juvenile Sex Offenders
- Sealing the Record of Conviction for Juvenile Offenders
The perception that juveniles who commit sex offenders are just like adults is plain wrong. In fact, juvenile sex offenders are similar to other juvenile delinquents and are quite different from adult sex offenders. Juveniles perceive risks differently than adults, and are less able to foresee probable consequences of their behavior. Juveniles are more influenced by their peers than adults. Juveniles are more impulsive. Solo offenders are more impulsive than group offenders. There is a high incidence of ADHD among juvenile sex offenders that must be considered when representing these young people. At the Meryhew Law Group our lawyers understand these differences and are trained to explain and understand juvenile behavior in advocating for our clients.Juvenile Brain Development Must be Considered
Physiologically, there are big differences between juvenile brains and the fully developed adult brain. The frontal lobe is the last area of the brain to develop, and is not complete until people are in their mid-20s. This is the part of the brain involved with executive functioning: Planning, judgment, initiating and stopping actions, anticipating outcomes and consequences, inhibiting and suppressing inappropriate social behavior. Likewise, the Limbic System has not reached full capacity in adolescence. This deals with processing and managing emotion and motivations. When fully developed, the Limbic System keeps people from “overheating” and helps maintain control over behavior. Explaining and understanding the effects of this underdevelopment of the brain is central to the way our attorney approach these cases.
The effects of this underdevelopment on juvenile behavior can be profound. As a result of these deficits, juveniles do not read emotions in others as well as adults. The juvenile’s brain uses more of the emotion areas and less of the frontal lobe for executive functioning. The assumptions behind many of the policies adopted in the 1990s that involve harsh penalties for juvenile sex offenders are being increasingly called into question as the research on this population reveals a far different reality. We now know that juveniles who engage in sexual misconduct are very different from adult offenders due to the impact of juvenile brain development and impulsivity in sexual offending by juveniles. These behaviors resolve as juveniles mature, leading to very low re-offense rates for juvenile sex offenders. We also know now that treatment interventions are effective in further reducing juvenile sex offender re-offense rates.
At the Meryhew Law Group our attorney is leaders in advocating for juveniles accused of sex offenses. Brad Meryhew has spoken on this topic at local and National conferences and has published on this topic. Representing Juveniles Charged with Sex Offenses; Leading Lawyers on Examining Recent Trends in Juvenile Law and Building a Successful Defense, available at (Amazon.com).
While there is a widespread belief among the public that juvenile sex offending is at an epidemic and all-time high, the fact is that rates of juvenile sex offending overall have been generally stable in recent years. However, there was a time when this was a growing problem. From the late 1980s through the mid 1990s, there was a significant increase in juveniles committing violent offenses, including sexual violence. As a result, the sanctions for juveniles who commit sex crimes were intensified along with reforms in adult sex offender management, including longer sentences, sex offender registration, and community notification statutes. At the time those policies were adopted, policy makers were making assumptions about high re-offense rates and poor treatment results by juveniles that have not proven true over time, yet those harsh and often counterproductive sentencing schemes remain in place. The challenge for the defense attorney in this environment is to advocate for a result for their client based in research and the proven effectiveness of treatment, rather than the harsh sanctions and misguided assumptions of policymakers from a different era.
If your child or a child you care about has been accused of sexual misconduct, our attorney has the experience and the expertise to advocate for that child effectively and persuasively. Contact the attorney at the Meryhew Law Group today for a free initial consultation.
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Punts are one of the earliest type of craft to be depicted in sketches and paintings by artists.
With their flat bottoms making them stable and capable of carrying heavy loads in shallow waters, they soon became the small work horse of many rivers - being ideally suited to transportation of both goods and people. Crossing ferries have been documented since medieval times as their operation and ownership were often a matter of dispute.
The basic form of construction made for ease of build and helped lead to the popularity of this type of craft for many methods of fishing amongst fisher folk.
Checking the eel traps.
There is no doubt that the punt was once a common sight on the river. Through the ages its shape developed with a rising bow and stern particularly on punts built for use in the tidal reaches of the river, where they were used extensively in connection with long-net fishing of the salmon.
Only two of these boats remain - both built from lines passed on through many generations, constructed in the 1910s by Prossers of Minsterworth, wheelwrights, agricultural blacksmiths and carpenters. One boat was built for Tom Greening and is now in storage at the National Maritime Museum, London (in poor condition), and is well documented in "Working Boats of Britain" by Eric McKee.
Its sister craft, built for Anslem Browning, fished at Bollow Pool until the 1980s when the fisheries became uneconomic through the decline in salmon stocks and availability of cheaper farmed fish. There it remained on the river bank until 1998 when it was restored into working condition.
The Severn punt goes to
Henley Traditional Boat Rally.
Construction of Punts built at Minsterworth 1910.
The building of these boats which were primarily built for salmon fishing ws influenced by the nature of the work expected of them. It was important that there were no rips, thwarts or other obstructions which the net could become tangled on. The boat would be constantly grounding and colliding with the banks when moored due to the variable level of the tidal river and only taken out of the water at spring tides due to the high river banks, then with the assistance of a horse or tractor to drag it.
This led to the use of thick timbers on the base to give the nailed joint rigidity. In early years materials would have been found locally, however timber imported to the local docks of Sharpness and Gloucester were also used in later years.
If a boat is in the river as the bore wave sweeps towards it the safest place to meet it is in the centre of the river as the wave breaks along the banks which could easily over whelm any small craft. The rising end of the punt helped it ride over the wave head on.
To make mooring both quick and easy a pole is dropped through a hole in the prow of the boat - so useful to the fisherman who needs to help pull the net in without delay.
Strong currents, muddy river beds, variable depths and the power to pull the net, made it impractical to use a punt pole.
Eight foot long paddles are lashed to iron rings and the punt is therefore rowed in a traditional manner. These paddles were also used as bailers to shovel out water which drained from the nets.
The salmon fishing season started on 2nd March and would run to August and no fishing was allowed from midday Saturday until Monday morning. Other than these restrictions, hours of work depended on the height of the tide at times of neap tides many drafts would not be affected and would be able to fish near continuously, others would be restricted around the times of full and new moons as sea water surged up the river making it impossible to fish.
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Springs and Rams
‘We’ve become deaf to the music of underground streams, forgotten how to celebrate the sacred springs’… in this beautiful piece, writer Anne Boileau pays tribute to an ancient source of water and to the machines that worked their own magic with it.
Whalebone Spring; Peter’s Spring; Ladle Spring; Pigeon Spring… just four springs among dozens, which are marked in blue on OS Explorer Map No. 195. Dozens of others are called simply Spring and they occur along the Blackwater and close to our village.
But they’ve forgotten their names.
They may well have been sacred, dedicated to Saint Anne, or Saint Bridget, or Saint Cuthbert (Curds Hall), and in pre-Christian times would have rejoiced in Celtic names and later perhaps, when Stane Street was built straight as a railroad, superimposed upon the existing ancient little paths and tracks, the names of Roman deities.
Bradwell-juxta-Coggeshall means Broad Well and you can see the clear pond beside Holy Trinity Church. We have become deaf; we no longer hear the subterranean music of those pure mineral-rich streams that well up from the deep aquifers and run cheerfully beneath our houses, roads, churches… water music as fluent as Mahan Esfahan playing Bach’s Well Tempered Klavier on the harpsichord as he did on May 5th at Wigmore Hall.
We curse them when they rise unbidden in our basements, but isn’t it reassuring, after such a dry April, to know that our valley is peculiarly blessed with so many sources of potable water!
Springs and wells were not only cherished and celebrated; their usefulness was often enhanced by the installation of a hydraulic ram (you can see these marked also in blue H ram on the map).
They’re simple pumps that use kinetic energy and work like this (I found it demonstrated on YouTube):
The stream is captured in a pipe and a small chamber is constructed to capture the flow. Because the inlet is wider than the outlet, when flow is brisk, pressure builds up; this kinetic energy pushes open a third valve at the top and water gushes up to a higher level to fill your tank or irrigation channel (levada) or pond.
The countryside must have throbbed with the heartbeat of rams, which were invented in the 15th century – they knew a thing or two about engineering, just look at the clocks and bell foundries and armouries of that time.
Up until the 1960s, rams would still have been maintained on a regular basis, each one having its own guardian. He goes to where it’s hidden, near a ditch or under a hedge or beside a bridge, and listens: is it beating?
If not, dig down to it, unscrew it, take it apart, clear the blockages, check all valves and parts, grease well, reassemble, reinstall – then listen with satisfaction to the beating heart kerplunk kerplunk kerplunk.
Robin Greatorex remembers a man called Tim who took him to a ram in Wakes Colne and showed him how to repair and reinstall it 30 years ago.
Trevor Disley remembers playing with his friends in Ladle Meadow by Cradle House and drinking from Ladle Spring. It was delicious water but is now dissipated into the marshy land by Robins Brook.
One morning, you get out of bed, go into the bathroom and use the toilet. It flushes but does not replenish the cylinder. You turn on the tap in the basin to wash your face and it’s dry. One drip. You go out into the street and some neighbours are already there, in West Street, in East Street, in Church Street, in Stoneham Street. In Consternation Street. Have you got water? No. Nor have I. How can we make our tea? Or wash? Or cook? Or survive… with no water?
The complex computer-controlled Ely Ouse Transfer System has suffered a serious glitch; it might be sabotage, they don’t know. Whatever the cause, the system has failed. So we must take our pails and go to the village pump. But where is the village pump? Where are the ram maintenance men? Who knows about the springs? Those blessed sources of clear potable mineral-rich water? Clear, clean, pure blessed water.
We’ve become deaf to the music of underground streams, forgotten how to celebrate the sacred springs. The steady percussion of hydraulic rams, reassuring as heartbeat under the ground, has fallen silent.
One day we may need to revive them, turn to those ancient sources and learn again to honour them.
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Expected learning outcomes
The candidate have knowledge of plan-driven and agile methodologies in software development and understand basic administrative and technological aspects of the specification, development, testing and maintenance. They know the basic principles in software architecture and design and the value of user participation.
The candidate can apply object-oriented methods and techniques of requirements specification and are able to establish project procedures using agile development methodology. They can work from project idea to a recommended sketch for a software solution in small projects and know the benefit of tools in different parts of the software development process.
The candidate gain awareness of the software's role in business and community and the role of management, teamwork and documentation in software projects.
The role of software applications in companies.
Plan-driven and agile software development methodologies
Project management and risk analysis
Methods and techniques in requirement specification and analysis (UML)
Principles in Architecture, Design and Testing
Tools and Configuration management
Form(s) of Assessment
Written exam, 3 hours
Evaluation of Project(s)
Form(s) of Assessment (additional text)
Written Exam, 3 hours (counts 40%)
Evaluation of Project(s) (counts 60%)
Each part must be individually approved of.
Alphabetical Scale, A(best) – F (fail)
Re-sit for the written exam in August.
Code D: No printed or hand-written support material is allowed. A specific basic calculator is allowed.
Read more about permitted examination aids.
Software Engineering, Ian Sommerville, 10th ed
Additional materials will be available at semesterstart.
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Even if you don’t celebrate the Helloween holiday, some ideas may come in handy. Pumpkin is ideal for creative experiments in decor, you need only a little inspiration and fantasy. Nowadays, there are many ways to decorate face of pumpkin pattern: from simple projects to high-quality artistic designs using modern pumpkin face paints. Embody any idea, and the festive mood will be provided to you.
So, before you start making pumpkin face paint makeup on Halloween, prepare everything you need. First of all, you will need a lot of orange pumpkins face paint. Professional makeup is not mandatory. To make the skin on the face orange, it is enough to use paints of this color. Today is feature of the entire gamut, from tender peach to fiery.
Orange shades in pumpkins with painted faces makeup should be combined with saturated black color. For this, shadows of such a shade and a marker are suitable: it has a thicker applicator, unlike the classic.
Pumpkin face paint makeup
Pumpkin makeup is a pretty popular idea for Halloween. In order not to accidentally meet someone with a similar image, we recommend doing art makeup.
- Apply a tonal cream to your face.
- Then select the cheekbones with the sculpting powder.
- Circle the areas under your eyes with a black sub.
- Draw several pumpkins in each zone with orange face paint.
- Paint the remaining areas with black shadows.
If you do not want to depict pumpkin on your face in the literal sense of these words, we recommend simply using the appropriate palette of paints. Do not forget that harmony can be achieved only by thinking through all the details. Try to think over them beforehand.
In Halloween, strands can be painted in orange with paint that does not injure hair and is easily washed away with shampoo. You will look bright and unusual.
How to draw pumpkin faces with paint?
There are many tools for drawing patterns of pumpkin on the face, while each of the tools will have its own characteristics. As the means by which the colorful composition can be formed, the following are distinguished:
Decorative cosmetics. This means is very effective and convenient to use since the components are designed to be applied to the face. Such formulations are most often hypoallergenic, but some parents do not believe that the agent can be used for pediatric skin. As a drawing element, bright mascara, lipstick, powder, shadows of unnatural or unusual colors can be used;
Аquagrim. This is the main instrument in the hands of the face art professional. This agent is completely harmless and does not cause any allergic reactions during the whole process of drawing pumpkin faces with paint, which allows to be used it even for the most delicate pediatric skin;
Water-based markers. Use markers only when you want to draw clear lines or make a complex pattern. Water markers are harmless to the skin, but sometimes, they can be difficult to flush;
Food dyes. This is the only drawing tool that should be prepared in advance. To prepare the agent, a common baby cream should be mixed with a food dye of the desired color to obtain the desired tint. This drawing technique is also used quite often, since it does not cause any negative reactions in the body.
Children’s aquagrim, for the most part, is completely safe for children. However, before decorating the pumpkin faces with paints of a native child, you need to make sure that they are safe. The paints must not contain black hen. It’s a dangerous carcinogenic drug.
When applying funny makeup, water is used. It must change after the end of each drawing. Otherwise, a small, sometimes even inconspicuous, skin disease of one baby will easily find new owners. The same rule applies to tassels. They must be thoroughly washed after each pattern applied.
Contraindications to aquagrim application
- Despite the fact that aquagrim is made high-quality hypoallergenic face paints, there are a number of denials.
- Aquagrim should be abandoned if there are rashes or wounds on the child’s skin. Children under three years old. This is due to the fact that they are small and simply will not be able to sit and wait for the master to do his job.
- Do not risk allergic reactions. To be reinsured, you need to apply paint to the back of the palm. If there are no problems, you can calmly start painting the face.
Different ways of drawing pumpkin face paint
To apply pumpkin aquagrim, you need to have a palette of basic colors, several types of brushes, sponges, a glass of water, stencils with asterisks, hearts and flowers, jars with sparkles, a mirror, wipes for wiping hands and hands. All listed items can be bought in a special set for aquagrim or purchased separately. The quality of pumpkin face paint directly depends on the consistency of the paints.
When applying pumpkins with painted faces, it is important to choose soft, elastic brush, with rounded ends.
- Rounded brushes are most often used, but they also have different sizes and thicknesses. They allow you to change the thickness of the lines and draw sharp corners.
- A fan-shaped brush can cover a large space. They have a wide swab and thinner edges.
- Rounded flora brush is most often used to apply tears, flower petals and other lines.
Tools with synthetic fibers are significantly inferior in softness and subtlety to brushes with a natural base.
To create unusual pumpkin drawings on the faces, you will have to buy special face paints for aquagrim, brushes, sponges or small sponges, water dishes. For some drawings, rhinestones will be needed, it will be especially good to look with such shiny objects of aquagrim for girls.
Pumpkins with painted faces
Pumpkin is one of the most popular symbols of autumn. And drawing pumpkin with painted faces is a wonderful way to imbue the spirit of Halloween. Take a piece of paper, a pencil, an eraser. Painted pumpkin can be used as a stencil for applying a pattern to the surface of the fruit.
Phased drawing of pumpkin face paint:
- Draw a circle that will become the main face. It should not be completely round, but slightly flattened. Make the lines thin so that they can then be wiped with an eraser.
- Now you need lines of symmetry. Draw vertical and horizontal lines that divide the circle into 4 parts.
- Now you need to draw facial elements: nose, eyes, and mouth. And the main figures with which you can do this are triangles and circles.
- The simplest nose and eyes can be drawn with equilateral triangles.
- The mouth is made with arcuate lines.
- With the help of circles, crescent eyes are easily drawn.
- For a complex picture, you need to add vertical lines, like a real pumpkin. They will divide the fruit into large rounded segments-slices.
- In the final step, add a half-shade to make the image look voluminous.
- Color the picture.
Pumpkin with a carved grinning face is a traditional Halloween attribute. According to legend, pumpkin drives evil spirits away from home.
Pumpkin faces with paint
Pumpkin is not only a useful vegetable, but also a symbolic Halloween dish. On this night, everyone will put a pumpkin on the table with a carved face, which will add even more entourage to the celebration.
- Choose only ripe fruits in the store, which still do not have a very hard peel. This will help you more easily cut out the emotions of the pumpkin.
- Examine the fruit for damages or rotten places to keep the pumpkin standing longer.
- Cut the pumpkin tail or cut the bottom with a sharp knife.
- Now we are moving to remove pulp and seeds from pumpkin. You should do it with a spoon with sharp edges.
- Draw a muzzle on a pumpkin with the emotion that you like most.
- Cut the muzzle with a sharp knife along the contour you made.
- To make the muzzle longer beautiful, lubricate the sections with wax.
- If the pumpkin began to tighten, you can put it in the water for several hours.
- You can grate the pumpkin from the inside with cinnamon or nutmeg so that there is a pleasant autumn aroma.
The most common pattern on a pumpkin is considered a face mask. The pumpkin face with paint can be both cheerful and good-natured, as well as a terrible or vicious scream.
Pumpkin is one of the most important symbols of the “terrible” holiday. The night from October 31 to November 1 cannot take place without this important attribute. Drawings and pictures on pumpkins can be different – depending on fantasy and creativity. Cutting out the pumpkin for Halloween in the form of terrible monsters or good horns – a great pleasure for both adults and children.
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In 2015 our Foundation launches training volunteer project “Befriender”. The project aims to train volunteers to communicate with families raising children with autism. We expect that training program will be resulted by free social assistance to families with children with special needs, in particular with autism, which are in difficult situations.
“Befriender” includes three stages:
1. TRAINING. Practical skills of communication with children with autism. Phase include three trainings in Kiev:
January 29, 2015. Training “The legal basis to help families who are raising children with special needs. The legal basis of voluntary activities”. Trainer Larisa Ostrolutskaya, key specialist of Kiev city center of social services for families, children and youth.
February 12, 2015. Training “Communication and basis for the behavior’s analysis in working with children with autism. Work in the family”. Trainer Irina Kalinichenko, practical psychologist, specialist in ABA alternative communication system, methods of evaluation and correction of behavior.
February 26, 2015. Training “Building of relationships between volunteer and child, volunteer and family of child with autism. Self-help and psychological relief in the work of volunteers”. Natalia Bondaruk, trainer, practicing psychologist, Gestalt therapist, family counselor.
TRAININGs are supported by Canada Fund for Local Initiatives
2. OBSERVATION. This phase involves the practice of observation in the Foundation project – kindergarten for children with autism “Child with future”. The purpose of “observation” is a personal acquaintance with behavior of a child with autism.
3. HELP FAMILIES. Foundation “Child with future” selects families who are in difficult situations for participation in project “Befriender”. Foundation coordinates work of each volunteer in the family.
Foundation plans to train up to 25 volunteers.
We invite everyone to take part in the project. Before January 15, 2015 please write an application addressed to the project coordinator Kateryna Dudkina email@example.com in free form, which should contain the following information: name, place of study/work, contacts (phone, e-mail), a letter of motivation “why I want to take part in the project”. For any further information, please contact Kateryna by phone 067 231 80 81
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Skip Nav Destination
1-1 of 1
Keywords: spiral curricula and inquiry (spiralquiry)Close
Journal: The American Biology Teacher
The American Biology Teacher (2018) 80 (3): 228–234.
Published: 01 March 2018
... and Permissions web page, www.ucpress.edu/journals.php?p=reprints . 2018 quizfolio course-based undergraduate research experiences (CUREs) spiral curricula and inquiry (spiralquiry) culturally responsive mentoring for research affective learning SOAR metacognition resiliency self-confidence self...
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TOPICS OF THE DAY.
nu; REVAL MEETING. THE significance of Royal meetings is often exag- gerated, but no friend of peace and of a better understanding between the nations can fail to recognise the importance of the visit paid by King Edward to the Emperor of Russia. Following as it does upon the visit of M. Fallieres to this country, and coming just before the forthcoming meeting between the President of the French Republic and the Russian Sovereign, it is in effect a proclamation to the world that the three Powers, Russia, France, and Britain, are determined to do all they can to maintain the peace of the world, and to maintain it in the right way,—that is, by avoiding all action which may give rise to controversies and disputes, and by taking care, while safeguarding their own rights and interests, not to infringe in any degree the rights and interests of their neighbours. Leagues of peace in limes past have had a bad name with diplomatists, as too often belying their description ; but the present understanding between the French Republic, Russia, and Britain is open to no such objection. It is patent to the whole world that each of the three Powers is most sincerely anxious to avoid any breach of the peace of Europe. They are all honest devotees of the status quo, even though in the cases of France and of Russia there might be a good deal of excuse for a desire not to perpetuate the existing condition of things. The more fiery French patriots are apt to regard the European status quo as a grievance, since it means acquiescence in the loss of the provinces. Again, those Russians who are inspired by Pan-Slavist aspirations, and hold strong views as to the mission of Russia in South-Eastern Europe, are inclined to dislike the idea of binding themselves to maintain the present configuration of the world. Never- theless, all three Governments have come to an under- standing which in essence, if not in name, means keeping the peace, and also keeping things as they are. The result, as we have said, is an understanding which is devoid of the slightest flavour of aggression, and which only asks that the nations shall let each other alone and practise the principle of " live and let live." The notion of the three Powers either individually or collectively setting light to the European powder magazine is absolutely unthinkable. No Power, therefore, can show itself aggrieved at the understanding—or shall we say, at the three Powers standing together in the interests of peace P—unless such a Power has aggressive and disruptive intentions which are hampered by it. Let us hasten to say that we do not mean to suggest that there is any Power which seriously regards the understanding as hostile to itself. It is true that certain organs of German public opinion have professed indignation over the meeting of the Emperor of Russia and the King, but to such news- paper utterances it is not necessary to pay too much attention. The German Government itself is well aware that no injury has been done or is purposed, and that there is no hostile intent whatever in the Reval visit. A break- water is no menace to a calm sea, though it is a great protection if the weather becomes stormy and the waves are lashed into fury.
Perhaps the best proof of the pacific character of the understanding between the three Powers is to be found in the manner in which it has come about. It is the force of circumstances that has brought them together rather than the acts of statesmen or the development of a far-seeing policy. For various reasons, and owing to a variety of circumstances, all three Powers found themselves anxiously desiring the same thing, and each willing to make con- siderable sacrifices to secure that thing. The thing was and is peace. But in the case of nations, as of men, those who desire the same object very strongly, and who are somewhat anxious as to whether they will obtain it, and, further, who are willing to make personal sacrifices in order to obtain it, are certain sooner or later to come together. The force that draws them is irresistible. As soon as the position is mutually understood an agreement is reached, even without a word being spoken. But though this is the case, it is wise that intercommunication should take -placa, and that matters of common concern should be freely discussed, for understandings between nations are fabrics which are all the better for being kept in repair. Thus Britain, Russia, and France, impelled to consult their common interest, peace, are finding that their object may be developed and secured by the well-directed efforts of the statesmen and Sovereigns interested. There is also a specific as well as a general benefit to be obtained by diplomatic action. When once nations realise that they have a great deal to gain by the preservation of the peace of the world, they easily advance to the position of seeing that it is very foolish of them to quarrel over details, and that it behoves them to come to an agreement in matters of minor policy. But when such agreements as to detail are formed, they at once react and help to consolidate the general understanding. We came to our agreement in detail with France because it had become obvious to the statesmen of both countries that it was necessary to their essential interests to preserve peace throughout the world. But no sooner had an agree- ment in detail been reached than it was found that the general understanding was thereby immensely strengthened. In the same way, the recognition that Russia and Britain are both interested in the maintenance of peace has led to a specific agreement between the two Empires, and will, we hope and believe, lead in the future to a still further " clearing up " of minor points of friction.
It is most satisfactory to note how far the promotion of good feeling with Russia has already gone. Who would have thought in the first year of the present century that in seven years' time we should find our politicians on both sides talking as if an understanding with Russia were the most natural thing in the world ! It is no doubt possible that in future years we may find new points of difference with Russia, and that she and we may be unable to agree on many matters of policy. The Reval meeting has, however, done one thing. It has made both nations and the world at large understand that the old condition of things under which Russia was supposed to be the " natural enemy " of this country has ceased to exist. Twenty, or even a dozen, years ago the "natural enemy" theory, and the notion that we wore bound to be in a perpetual state of friction with Russia, entirely held the field, and those who challenged it—as the Spectator did— were regarded as either ienoramuses or " cranks." Yet now it is one of the commonplaces of diplomacy that there is no reason why Russia and Britain should be at loggerheads.
It is said that the German Emperor will shortly meet the Czar in the waters of the Baltic. We sincerely hope that the rumour is true, for the last thing we desire is that any encouragement should be given to the view that the understanding between ourselves, Russia, and France is intended to isolate Germany. Unless a condition of thinas inimical to the outbreak of hostilities, or, in other words, unless peace, is to be regarded as bringing isolation upon Germany, the idea of the triple understanding being injurious to her is utterly untenable. The better the relations between the German Emperor and the Emperor of Russia, the more we shall be pleased, and it will be a source of increased satisfaction if the visit of the Kaiser to the Baltic should be followed later by a visit to Britain. Should the German Emperor again elect to spend an autumn holiday in the South of England, the news will be received here with the utmost pleasure. The German journalists, German burgomasters, German pastors, and German working men whom we have been delighted to receive of late have, we trust, learned that there is no hostility here to the German people or the German Sovereign,— a fact which, we believe, the German Emperor already fully realises, and of which the British people will be only too glad to give him further personal proof whenever he can find time to take another holiday in Hampshire.
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Octavio’s Journey contains an allegory for Venezuela’s history and you will probably get a lot more out of it with some prior knowledge. I know next to nothing about Venezuela but can only assume it’s had the same problems of colonisation as the rest of South America.
The scene where a burglar politely expects a homeowner to disclose the location of a key or otherwise destroying something they both hold dear feels very much like it’s referring to a specific event. In a more general term I can see it portraying the relationship between the indigenous people and the Spanish; the oppressed having no choice but to give in to the oppressor.
Without the knowledge of the country’s history, it read more like a collection of fable-like stories, connected by Octavio’s presence. It talks of the introduction religion and the modernisation of Venezuela.
At the start of the story Octavio is illiterate. A visiting doctor forgets his prescription pad and writes on Octavio’s table instead. Unable to decipher the scenarios but unwilling to admit his ignorance, his resulting actions go to show the lengths people will go, to hide their illiteracy.
Octavio is fascinated by the ancient symbols he sees in a friend’s house. As circumstances make him travel far from his home, he grows, helps others and learns to read. Perhaps inspired by the culture that has been wiped away by the colonists. I would love to hear from people who read this knowing more about Venezuela than me!
Originally written in French by Miguel Bonnefoy, Octavio’s Journey has been translated into English by Emily Boyce for Gallic Books. It will be available in ebook format from 13th March 2017 and in paperback from 17th March, although swing by Belgravia Books and you’ll be able to get an early copy. Thanks go to the publisher for providing a copy for review.
Goodreads | Amazon | Waterstones | Hive | Wordery
Disclosure: I received a copy of this book free of charge for review purposes only. Receipt of a book does not guarantee a review or endorsement. My reviews are my honest opinion and are not biased for the purpose of personal gain.
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Even if StoryGraph has gotten better I still haven't forgiven it for importing all the wrong editions of my books. It was also a bit lonely.Follow
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I recently provided a list of 12 phrases to avoid in sales emails. Today, it's phrases that marketers should avoid, not because customers hate them, but because the use of these phrases encourages bad marketing. Here they are:
1. "Demand creation"
Example: "This trade show is a demand creation activity."
No amount of marketing can "create" demand. Either customers need a product or they don't. If they do, then the demand is already there. If they don't, then demand doesn't exist. The most marketing can do is help connect the demand with the product.
This phrase results in bad marketing because it encourages marketers to think that their job is to do something to the customer rather than for the sales team.
2. "Drive sales"
Example: "This program will drive sales into new industries."
This phrase implies that marketing is in control of the sales activity. But for every product that requires a salesperson, only a salesperson can makes a sale happen. All marketing can do is to help the sales group fulfill its goals. It's not "driving" anything.
This phrase results in bad marketing because it folds the sales function under the marketing rubric, rather than the natural order, which is t'other way 'round.
3. "Brand equity"
Example: "This advertisement will increase our brand equity."
The entire concept of "brand equity" is mostly a scam. While huge, instantly-recognizable brands (like Coke and Sony) do have value (though probably less than they claim), most brands could disappear off the face of the earth and nobody would notice.
This phrase results in bad marketing because the squishiness of the concept makes it impossible to measure whether any given marketing activity was worth the cost.
4. "Hot sales lead"
Example: "We passed some hot sales leads to the sales team."
A sales lead is only "hot" if a salesperson can close it quickly. Because of this, marketing only knows whether a sales lead is hot after a salesperson has closed the sale. Declaring that a sales lead is hot before it closes is fundamentally wrongheaded.
This phrase results in bad marketing because it encourages marketers to judge the quality of sales leads based upon their own guesstimate rather than actual usefulness.
5. "Under embargo"
Example: "This product announcement is under embargo."
Marketers use this phrase when sending out press releases, hoping that an air of secrecy will pique media interest. However, the PR folk would be absolutely delighted if they got some early ink.
This phrase results in bad marketing because business reporters have an attention span of about 10 minutes and delete anything that they can't immediately write about.
Example: "We are making an investment in market research."
With an investment, there's a direct connection between the money you put in and the money you take out. If the connection is vague or indirect (as with most marketing activity), it's spending not investing.
This phrase creates bad marketing because it encourages marketers (and everyone else in the company) to forget that marketing is always an expense.
Example: "Our new product requires a robust set of features."
What does this word mean, exactly? For me, it conjures up the image of a red-faced, slightly-overweight, middle-aged guy wearing Speedos while running down the beach and calling out: "Hey, everybody, look! I'm robust!"
This phrase encourages bad marketing because it allows marketers to have arguments and discussions over a term that has no real meaning.
Example: "This ad campaign is customer-focused."
What? What? If a marketing activity isn't about the customer, why would anybody bother to plan, fund or execute it? Shouldn't everything be about the customer?
This phrase results in bad marketing because the fact that a marketing group labels an activity as "customer-focused" implies that some of what they're doing isn't.
Like this post? If so, sign up for the free Sales Source newsletter.
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I got an iPad2 for my birthday last summer, and although I use it every day at home, I have rarely let it venture into the classroom. The one exception was a poorly executed attempt to place it under the document camera so students could see the spinning RNA molecule in my Molecules app. I didn’t have a way to connect the iPad to the projector in the classroom, but I thought the document camera would be a decent substitute. I was wrong. Glare from the overhead lights made the exercise futile.
I finally decided that it is high time to do more with my iPad. So for this blog post I am going to lean shamelessly on my OU colleague Dr. Mark Morvant, an innovative organic chemistry professor who gave a presentation on using iPads in the classroom last January. This post is based on the notes I took during his session.
First, you need a way to hook up your iPad to your computer and/or the projector. There are multiple ways to do this. For example, I just bought an Apple VGA adaptor, affectionately known as a dongle, for $29 at our campus IT store. This will allow the projector in our classroom to mirror the display on my iPad. I am already excited about the potential to show off that Molecules app during the chemistry unit in my biology class this fall.
Another way to hook up your iPad is to use Apple TV and Airplay to wirelessly stream data from your iPad to the projector. The giant advantage here is that the setup is wireless, so you can roam your classroom with your iPad. I’ll be honest, I did some searching around and still don’t understand how this works. That’s why I went with the dongle.
If you like to use a tablet PC in your class, you can use your iPad in much the same way. You can create your PowerPoint or Keynote presentation as usual, convert it to pdf, email it to yourself, open it on your iPad, and use iAnnotate to highlight parts of the lecture or scribble on it to your heart’s content (hint: you’ll need a stylus). After class, you can email the annotated lecture to yourself of your students, or you can put it in your Dropbox to retrieve it later.
Penultimate is another app that lets you write on the iPad; you can even import photos and annotate them with a variety of “pen” colors and sizes. You can use Penultimate to turn your iPad into a digital whiteboard, drawing diagrams of molecules or mitochondria or muscle cells or whatever else you might want to depict in class. And again, you can save your masterpiece and send it to Dropbox for posterity. For good clean iPad fun, you can’t beat Penultimate.
Dr. Morvant likes to roam the room, so he goes wireless, and he likes to get students involved in the class. So he sometimes puts a question on the iPad and hands it along with the stylus to a student to answer while the rest of the class watches. Hint: if you do this, lock the rotation (Settings –> General –> Lock Rotation) so the image doesn’t rotate every time you hand over the iPad.
If just preserving your images isn’t enough for you, you can record your voice and your sketches to create videos as well. Dr. Morvant mentioned Screenchomp as a useful, highly rated, free app that helps you achieve that goal.
Of course, I have only scratched the surface of what you can do with iPads in the classroom. You can check out Apple’s own iPad education site for more ideas, and of course the iTunes app store is full of education apps for the iPad. Hmm, this Powers of Ten one looks interesting; its goal is to help students visualize the scale of biology. Maybe I’ll spring for it soon.
If you teach with your iPad, please feel free to contribute your own ideas, favorite strategies, and best practices. I am a novice but am eager to learn more.
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Discover practical ways to critically appraise scientific literature, including the conduction and interpretation of systematic reviews and meta-analyses. Additionally, you will learn how to conduct literature searches using online academic databases, hear about economic evaluations, and understand how clinical practice guidelines are used to guide decision making.
This course includes the following 11 lectures:
- Overview of Systematic Reviews
- Finding and Managing the Evidence from the Biomedical Literature
- Intervention Reviews Methodology
- Meta-Analysis of Clinical Trials: Direct Comparisons
- Introduction to Meta-Analysis: Indirect Comparisons
- Meta-Analysis of Non-Randomized Studies
- Diagnostic Test Evaluation
- Clinical Practice Guidelines
- Economic Evaluation
- Decision Analysis for Outcomes Research
This course is intended for anyone interested in comparative effectiveness research (CER) and patient-centered outcomes research (PCOR) methods.
This course is supported by grant number R25HS023214 from the Agency for Healthcare Research and Quality.
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At least 15 people were killed and 40 were feared missing after a cloudburst triggered flash floods near the holy cave shrine of Amarnath in India’s Jammu and Kashmir on Friday.
The cloudburst struck around 5.30pm local time. Floods and heavy rainfall also damaged 25 tents of the pilgrims.
Indian Prime Minister Narendra Modi in a tweet said that he was “anguished” by the cloudburst.
“Condolences to the bereaved families. Spoke to Manoj Sinha (Lieutenant Governor of Jammu and Kashmir) and took stock of the situation. Rescue and relief operations are underway. All possible assistance is being provided to the affected,” Modi tweeted.
A Spokesperson of the Indo-Tibetan Border Police or ITBP said that the situation is under control despite the rains still going on, and the Amarnath Yatra “pilgrim’s ritual” was halted for today due to bad weather, but it would be resumed tomorrow.
The pilgrimage began this year on June 30 after a two years gap due to COVID-19 pandemic, and more than 72,000 pilgrims offered their prayers at the shrine.
© Fourth Estate® — All Rights Reserved.
This material may not be published, broadcast, rewritten or redistributed.
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Eucalyptus platypus (platypus gum) is small to medium tree growing around 5 - 7 metres in height. it has a rounded form to ground level with thick dense foliage thus indicating that this species is an excellent choice for screening and windbreak applications. It is a robust coastal species and is also extensively planted inland on infertile alkaline sandy soils and well as heavier soils. It is very adaptable species which will grow almost anywhere other that in very wet and cold areas.
Eucalyptus platypus (platypus gum) has cream/yellow flowers usually occuring from spring to summer.
Please click here for detailed ordering information.
Click on Map to Enlarge Image
Notes on Maps.
Generally, the concentrated clusters of markers represent the geographical range where this species occurs naturally. Outlying markers and geographically disassociated markers represent observations of the species in cultivation and/or recorded in herbaria etc.
These maps are provided by, and are used with the permission of, Australia’s Virtual Herbarium (AVH)
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An innovative scheme aimed at getting young people with learning difficulties into the workplace has been nominated for a Pride of Reading award.
Twelve young people were given the opportunity of a lifetime last September when Project SEARCH was launched as a partnership between Royal Berkshire Hospital (RBH), Brookfields School in Tilehurst, and Reading College.
The students were given placements in departments at the RBH, from renal and endoscopy to portering and maintenance.
Currently, 65 per cent of adults with learning difficulties want a paid job, but only 10 per cent get one.
Only 7.2 per cent of the 2,352 people with learning difficulties and disabilities in Reading, Slough, Bracknell, Wokingham, and Newbury are in full-time paid employment.
Project SEARCH has proved to be an amazing success, with seven of the former students now in full- time paid employment, one in further education and three looking for work.
In light of this it has been nominated anonymously in the A Great Place to Work category.
The students all started with the hospital in September last year, and continued until July, working in three different departments.
Robert Bundred, 23, of Barkham Road, Wokingham, is autistic. He is now employed by the hospital as an assistant dialysis support worker after completing a three-month placement in the department.
At the time of his placement he said: “I enjoy what I do a lot and get on well with the doctors and nurses.”
This scheme is designed to give students employable skills and confidence while also dealing with the workplace stigma attached to people with learning difficulties.
Brandon Mills, deputy headteacher of Brookfields School, said: “This scheme is about developing a sense of self worth for the students, showing them they have a valuable contribution to make in society.”
Steph Hayward, head of learning and development at the RBH, said: “We are delighted to have been nominated for a Pride of Reading award. The Project Search initiative has not only changed the lives of the students taking part in it but has also had a huge impact on staff at the hospital.
“In the departments where the students have worked, staff have talked about the job satisfaction they gain from helping to develop the students’ skills and the pride they feel in being part of an organisation that has wholeheartedly embraced such an initiative.
“Wherever the students go, they lift the spirits of everyone around them.
“We feel very privileged to be working with the Project Search students, who have demonstrated that they can work as well as anyone when given the opportunity. We are looking forward to welcoming many of the current class as colleagues here at Royal Berkshire Hospital, as well as working with a new class of students when they arrive in September.”
A Great Place to Work is sponsored by GCS Recruitment
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Since the early days of the Community it was realised that decisions on and planning and implementation of Community policies must be based on reliable and comparable statistics. So the European Statistical System (ESS) was built up gradually with the objective of providing comparable statistics at EU level. To view the ESS website press the link http://ec.europa.eu/eurostat/web/ess/latest-news
The ESS is the partnership between the Community statistical authority, which is the Commission (Eurostat), and the national statistical institutes (NSIs) and other national authorities responsible in each Member State for the development, production and dissemination of European statistics. This Partnership also includes the EEA and EFTA countries (video).
Member States collect data and compile statistics for national and EU purposes. The ESS functions as a network in which Eurostat's role is to lead the way in the harmonization of statistics in close cooperation with the national statistical authorities. ESS work concentrates mainly on EU policy areas - but, with the extension of EU policies, harmonization has been extended to nearly all statistical fields. NSIs operate under legal provisions of the European Union:
Regulation (EC) No 223/2009 of the European Parliament and of the Council – European statistics - New legal framework. OJ L 87, 31.3.2009, p. 164
as amended by:
Regulation (EU) 2015/759 of the European Parliament and of the Council of 29 April 2015 amending Regulation (EC) No 223/2009 on European statistics. (2) OJ L 123, 19.5.2015, p. 90–97.
On 29 April 2015 this Regulation was amended by the Regulation (EU) 2015/759 of the European Parliament and of the Council and you can access its consolidated version on eur-lex.europa.eu.
The ESS also coordinates its work with candidate countries, and at European level with other Commission services, agencies and the ECB and international organisations such as OECD, the UN, the International Monetary Fund and the World Bank.
In order to ensure the quality of statistical information and its own activities, NSIs follow the provisions of the Quality Declaration of the European Statistical System (ESS) (PDF) and the European Statistics Code of Practice (PDF) (for more information on the ESS quality requirements please see the Eurostat's quality website).
Since 2012 the annual ESS report is published each year.
The main purpose of the ESS report will be to enhance the visibility of the ESS and to give an overview of the most important achievements of the ESS over the last year. The report should also serve as a general accountability report and, therefore, be understandable for a wide public.
- ESS Report 2017 (PDF)
- ESS Report 2016 (PDF)
- ESS Report 2015 (PDF)
- ESS Report 2014 (PDF)
- ESS Report 2013 (PDF)
- ESS Report 2012 (PDF)
Eurostat publishes official harmonized statistics on the European Union and the euro area and offers a comparable, reliable and objective portrayal of a changing Europe. All Eurostat data are available free of charge on its website.
To ease understanding and enhance usability of EU statistics, a common set of tables available in national languages is released on NSI websites – the Lithuanian version is accessible via http://osp.stat.gov.lt/pagrindiniai-es-rodikliai.
European Statistical User Support centres have been established in nearly all Member States as well as in some EFTA countries. Their mission is to provide help to Internet users of European statistical data in the national language. The Eurostat website's key notions and schematic view in the national language are available at http://eurostatgidas.stat.gov.lt/.
Document updated: 2022-06-08
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<urn:uuid:651e05c5-1e8b-4ffe-8b19-f266ffe6056c>
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CC-MAIN-2022-33
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https://www.stat.gov.lt/en/europos-statistikos-sistema
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en
| 0.887576
| 793
| 2.5
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Appearance and Habits
Moles are found throughout mainland Britain where there is suitable soil for tunnelling. They tend to prefer woodland, grassland so can be found
on golf courses, parks and lawns. They are approx 12-16cm in length and covered in black velvety hair with large spade like front feet turned
outwards for digging. Their eyes are small and hidden among their fur, they do not have visible ears. The most obvious sign of the presence of
moles are moles hills (heaps of loose soil) on the surface of the ground. They feed mostly on earthworms but also on other invertebrates including
slugs and insect larvae.
The breeding season lasts from February to June and there is usually one litter per year. The young develop are born blind and without fur, they
develop rapidly and leave the nest at 5 weeks old.
Treatment and Control
To easiest way to check if moles are still present, is to level the hills and check after 2-3 days for the formation of new hills. If the underground
tunnels can be located it is possible for traps to be used although this is usually best left to the professional.
Please call Enviro-Tec for a free survey and quotation.
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CC-MAIN-2022-33
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http://enviro-tec.co.uk/mole%20info.html
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en
| 0.95983
| 273
| 3.15625
| 3
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The following link gives the List of Final year electrical projects for BTech and MTech
Voltage and current are the foundation concepts in electricity.
The idea of electricity arises from an examination of nature. We study a force between objects like gravity, acts at a distance. The source of this force is named as charge. A very clear thing about electric force is that it is huge, far greater than the gravity force. Unlike gravity, though, there are two kinds of electric charge. Opposite kinds of charge attract, and like kinds of charge repel. Whereas Gravity has only one kind: it only attracts, never repels.
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<urn:uuid:e29419e1-cdb5-4b2d-8130-db79e188903d>
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CC-MAIN-2022-33
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https://asokatechnologies.in/list-of-final-year-electrical-projects/
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en
| 0.957378
| 129
| 3.125
| 3
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As you’ve noticed from elsewhere on this website, this course uses an unusual instructional model. The course is based on an androgogical rather than a pedagogical model
- In child-style learning, the teacher is responsible for everyone’s learning.
- In adult-style learning, the student is responsible for making sure that everyone else in the group learns too.
I’m not passing responsibility to you; I’m sharing it. That’s what adult learning is all about — and you’ll be doing it the rest of your lives. As a result, shouldering your responsibility for the success of this course constitutes 20% of your grade.
What does this mean, in practice? I’ll be looking for the following things:
- Your presence, both physically and mentally in the classroom. This means full participation in discussions, etc. — the stuff that gives you a good participation grade in a normal course.
- Your intellectual leadership, esp. the degree to which you bring organization and energy to our projects and to your group presentations, new information and new ideas to class, and provide a sense of direction to our efforts.
- NB: So that I’m not just rewarding extroverts, this can also include conversations with me outside of class about the course direction and the topics we are covering.
- Your attention to others’ learning, and your active efforts to make sure that others in the group benefit from the course. This might include your direct interventions, but it also might include conversations with me outside of class.
- The depth and quality of your comments on other students’ blog posts.
- The amount and quality of the data that you bring to our various collaborative data exercises.
These matters are not mutually exclusive, of course. But they give you an idea of the kinds of things that I’ll be thinking about as I evaluate your work.
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<urn:uuid:b720d231-435e-4953-92b0-95c67907aff6>
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CC-MAIN-2022-33
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http://www.coolsociology.net/SOAN324WP/?page_id=210
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s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571284.54/warc/CC-MAIN-20220811103305-20220811133305-00473.warc.gz
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en
| 0.93975
| 403
| 2.828125
| 3
|
Use of water – Customary Law
Water rising on a property
Customary Law in Jersey allows owners of land unrestricted use of any water which rises on their land. They can use it as they think fit, even if such use exhausts it completely. If the water is not exhausted, it must be left to take its natural course, the landowner must not alter its natural course and divert it.
The adjacent property must receive any water which runs off when this is the natural way it would run. The owner of the lower property onto which water runs can’t require his neighbour to keep it or alter its course or prevent it from doing what it would otherwise have done.
It is not permissible to pollute water which will then flow onto lower land.
Water flowing across a property, not having risen there
When water does not rise on a property, the person whose land it flows over does not have the right to exhaust the supply in the same way as if the water source was on his property. He may use the water but he must not dam it or change the course of the water to the prejudice of property lower down.
The owner of land on which it falls has the right to keep it. He may also keep water falling on a road bordering his property as long as he does not damage the road. If the natural slope of the land upon which the rain falls carries the water from the land onto neighbouring land, the owner of the lower land is bound to receive it and cannot complain. Water falling onto a property must not be artificially discharged onto a neighbours land, by the use of gutters or water pipe.
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<urn:uuid:c72ae709-facc-475d-a8c6-d02666848f2c>
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CC-MAIN-2022-33
|
https://www.citizensadvice.je/use-of-water-customary-law/
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en
| 0.971337
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| 2.84375
| 3
|
The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper
Kaiser, Ivan I.
Gutiérrez, José María
Aird, Steven Douglas
Odell, George V.
MetadataShow full item record
A myotoxic, basic phospholipase A2 (pI greater than 9.5) with anticoagulant activity has been purified from the venom of Bothrops asper, and its amino acid sequence determined by automated Edman degradation. It is distinct from the B. asper phospholipase A2 known as myotoxin I [Lomonte, B. and Gutierrez, J. M., 1989, Toxicon 27, 725] but cross-reacts with myotoxin I rabbit antisera, suggesting that the proteins are closely related isoforms. To our knowledge, this is the first myotoxic phospholipase to be sequenced that lacks presynaptic neurotoxicity (iv LD50 approximately equal to 8 micrograms/g in mice). The protein appears to exist as a monomer, contains 122 amino acids, and fits with subgroup IIA of other sequenced phospholipase A2 molecules. Its primary sequence shows greatest identity with ammodytoxin B (67%), a phospholipase A2 presynaptic neurotoxin from Vipera ammodytes ammodytes venom. Hydropathy profiles of B. asper phospholipase and the ammodytoxins also show great similarities. In contrast, even though the amino acid sequence identities between B. asper phospholipase and the basic subunit of crotoxin remain high (64%), their hydropathy profiles differ substantially. Domains and residues that may be responsible for neurotoxicity are discussed.
External link to the item10.1016/0003-9861(90)90266-2
- Microbiología
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CC-MAIN-2022-33
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https://www.kerwa.ucr.ac.cr/handle/10669/29162?locale-attribute=en
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|
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| 0.853443
| 437
| 1.6875
| 2
|
MOTHERS, ARMED FORCES, AND HEALTH WORKERS STOOD OUT IN 2021, TWO YEARS AFTER COVID19 BROUGHT THE WORLD TO ITS KNEES
By Enid Ahumuza
Finally, 2021 is gone!
Hurray, What a Year!!
The world nearly brought to its knees by covid-19, whether by design or nature, it showed us that we all are because others are too.
This got me thinking, who are the icons of our country, whose lives are because we ARE!?
Our mothers topped the list, followed by our armed forces, and health workers in that order.
Society is corrupted by the capitalist mentality of me, me, and mine, and we think we can live and thrive with test-tube babies, robot soldiers, and un-manned weapons, but can we really thrive in isolation from each other as the human race?!
Until that debate is settled, let’s all stand up for the three critical pillars of our society.
Our mothers, the irreplaceable, indefatigable,
brave warriors that are mother’s, the souls that will do absolutely anything to protect their offsprings, raise a glass or a bowl to the strength of a woman, and be kind to women in the year 2022.
A hug for each one of you that lost a mother in this covid-19 pandemic, I know how you feel, life won’t be the same, but there will be laughter, after this cloud.
And to our armed forces, the selfless men and women that brave our worst, as we run for cover, or away from danger as they run towards it. The souls, that leave loved ones behind, whose families grow up without them, because they are on duty.
The ones that stand all day on guard or in our traffic, the officers and men that secure us and other nations, while we critique their every action and inaction, the person’s that see our worst as humans-The armed forces…
Whose lives are because we ARE!? you are appreciated… Salute to UPDF in Somalia, in South Sudan, in CAR, in DRC, we are very proud of your patriotism.
And lastly to the medics, those sober faces that we turn to at our hour of need, seeking assurance and hope in hopeless situations, the men and women t that see us at our ugliest and still care!!
What would humanity be, without you?
You have shone as stars during this pandemic, you have sowed hope, even when you were out of options, you have braved the pandemic, You are true warriors, and humanity is because you are.
And to you all that brings tears to these three categories, May 2022 be your worst year.
A Great New Year to you all.
|
<urn:uuid:79c00ea4-3d17-4850-9570-b9fd65545e0b>
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CC-MAIN-2022-33
|
https://westniletodaynews.com/mothers-armed-forces-and-health-workers-stood-out-in-2021-two-years-after-covid19-brought-the-world-on-its-knees/
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|
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| 0.955108
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| 2
|
An individual needs to create a bank account that is related to the global bitcoin form of the network which generates an extremely long-form password. Anyone from anywhere with the help of the internet can access can send and at the same time receive it along with having a hold on the bitcoin by using the public version of its key. Grimace Coin Chart is one of the leading cryptocurrencies.
How do these coins have value?
It is mainly decided by the properties that are associated with these cryptocurrencies. It should have the fixed along with being predictable based monetary supply. Unlike fiat form of currency new form of cryptocurrency cannot be created suddenly or even by the trillion by an unelected or elected official. There are many millions of bitcoins.
Mainly these Grimace Coin Chart operate which is completely based on the open-source form of code and it is transparent globally unlike that of fiat currency. At any time and anywhere an individual is free to verify the total crypto or bitcoin supply as well as its underlying form of code including the balance related to each account that is present on the ledger which is completely globally based.
This type of currency is secured by a cutting-edge form of encryption and even backed by energy which is a total of immense amount and get know by Read more on CoinSpeaker. If any individual as well any organization intended to undermine these currencies’ core encryption it will require an impossible form of energy amounts as well as a specialized form of computers including space. It is the most secure form of computing network that is available in the world.
Unlike traditional bank accounts, anyone from anywhere can get connected to the network of thesecryptocurrencies. Mainly Bitcoin is censorable and the network is having a transacting value.
How is it controlled?
When anyone holds the bitcoin, it is mainly controlled by the private key. Where a string form of randomized-based numbers, as well as letters that usually unlock a virtual vault, consists of an individual purchase. Each of such private keys will be tracked with the assistance of a virtual ledger which is familiar as blockchain.
They are never revealed it not only controlled by a single person or any organization which serves as the core of its value.
It’s a trending asset with lots of change in a very unique manner in the field of the financial sector.many agencies collect the data regarding these cryptocurrencies and allow the customers to use their products as well as services. It primarily includes the collection of data which is mandatory by law which is necessary to avoid the anti-money form of laundering or even to verify an individual identification and also protect them from any kind of fraudulent activities.
|
<urn:uuid:7ca8c87d-f24d-4e6e-9408-c326bb84ff32>
|
CC-MAIN-2022-33
|
https://www.online-flexeril.com/how-to-create-an-account.html
|
s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882573029.81/warc/CC-MAIN-20220817153027-20220817183027-00272.warc.gz
|
en
| 0.971917
| 531
| 1.984375
| 2
|
While picking an HVAC school program, the main thing that you consider is that the school you have chosen is a certified one. This is a critical factor since it implies that the preparation conferred will be at standard with the principles determined by HVAC associations. The most notable offices for HVAC programs are the National Center for Construction Education and Research, the Partnership for Air-Conditioning, Heating, and Refrigeration, HVAC Excellence, North American Technician Excellence and Research, Environmental Protection Agency, and the Occupational Safety and Health Service. Select a school that has no less than one accreditation.
Smaller class sizes are additionally critical, which implies you will get customized consideration from the educators. A decent HVAC school will likewise have an on-site science lab with proficient review devices. Visit the grounds and get a vibe of the place, the classroom, the offices and converse with the workforce, if conceivable. Additionally, see if they permit any adaptability in planning classes for working understudies, and how you ought to approach acquiring monetary guide if required.
Colleges of HVAC
These are only a couple of the various HVAC training focuses that you will locate everywhere throughout the United States: New England Institute of Technology in Palm Beach, Ferris State University in Michigan, Pennsylvania College of Technology in Williamsport, Pennsylvania, the Refrigeration School in Phoenix, Arizona, Brownson Technical School in Anaheim, California, the Northwest HVAC Training Center in Spokane, Washington, and the National Capital Chapter of the Air Conditioning Contractors of America in Maryland.
You should have a secondary school certificate or identical to select for an HVAC training program, alongside sound math and science abilities. School programs normally last from two to four years and relying upon the sort obviously you select, you will be granted an authentication, a partner’s degree or four-year college education in HVAC.
You will likewise locate various junior colleges and professional or specialized schools where you can agree to accept here and now programs, which keep going for a half year to two years. On the off chance that you don’t have sufficient energy to go to school full time, you can at present get your HVAC training, because of online courses. Make sure to ensure that the school is a certified one.
When you have effectively finished the HVAC course, the following stage is looking for accessible HVAC employments in your general vicinity. Your school will have grounds meets or will assist you with leads for appropriate openings in the industry. HVAC bosses incorporate HVAC producers, HVAC benefit organizations, HVAC temporary workers, property service organizations, mechanical designing firms, HVAC discount providers, building proprietors and some more.
For more insights on HVAC or an HVAC career see United Trades and their blog
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<urn:uuid:0beed713-93ce-4711-9aeb-db6965e4d366>
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CC-MAIN-2022-33
|
https://www.ddmachine.com/selecting-a-hvac-program/
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en
| 0.944761
| 591
| 1.898438
| 2
|
Carving A Jack O Lantern – Jack O Lantern Pumpkin With Bottom Opening For Led Tea Light
Carving a jack o lantern art,
Turned into the light was a pumpkin carving detailed pumpkin jack olantern spectacular at these free poster size 2500x1700px kb show more by people used them specifically to look like a bit of pumpkins that the spice then pass by bringing it has turned into works of your presentation the yearand this jackolantern. Who once their identity was a family try carving intricate designs for carving artist then you must have over the pumpkin geek crafts easy to hunt for you do you searched for you some of the halloween pumpkins and no matter what youre looking for everything.
Tags: carving a jack o lantern art.
Back to: Carving A Jack O Lantern
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<urn:uuid:1b6395ad-146f-4d15-bc97-abae0d756a86>
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CC-MAIN-2022-33
|
https://lorenzocafebar.com/carving-a-jack-o-lantern.html/carving-a-jack-o-lantern-jack-o-lantern-pumpkin-with-bottom-opening-for-led-tea-light
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s3://commoncrawl/crawl-data/CC-MAIN-2022-33/segments/1659882571745.28/warc/CC-MAIN-20220812170436-20220812200436-00473.warc.gz
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en
| 0.933037
| 164
| 1.53125
| 2
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Movie theatre "Senasis trestas" [The Old Trust]
Elena: "While drinking my morning tea, I read an article about the old Kaunas movie theatres:" It's incredible, but today in Kaunas, out of almost 40 old movie theatres, only one had survived and is still operating. The rest became ghosts or a place where other activities are being developed. " As I‘ve read those words, an old story came to my mind. I couldn't wait to finish reading and find out what was that small and cozy movie theatre; I was lucky enough to go there once (when I came back, after a while, I didn't find the movie theatre there - there was a court instead).
Apparently, the theatre was demolished in 2006, and the court got established here due to its strategically convenient location. Definitely, A. Mickevičiaus Street is in the very heart of the city, and all the important institutions are easily accessible: on the other side of the road - Kaunas interrogation isolator, next to it: Kaunas University of Medicine, where I have studied as well.
I remember while looking through a window in a pharmacology laboratory, you could observe isolator‘s post office operations: through a slatted window of the third floor, a rolled paper note tied to a string – slowly moving down, until it finally reaches the window of the second floor. Someone’s hand grabs the note and a few minutes later - ties the answer, pulls the string for a few times, and the message starts traveling up. All-day long: up and down, up and down...
And that story about the movie theatre goes like this.
Back in 2006, “Vilnius Ghetto“ was released. Since the movie was created by a Lithuanian film studio, and I am really interested in this historical topic, I‘ve decided to go. As I‘ve read in a poster - the film had to be screened in a movie theatre near the university - it so convenient going there after the lecture.
I remember it was warm and green. An evening. I took a bus going down the Parodos hill road, got off on Kęstučio Street, turned to Mickevičiaus Street, as I‘ve passed the interrogation isolator - went inside the university. So silent in there. The lecture was canceled.
I‘ve crossed the road, bought a ticket, and entered a small, cozy auditorium. It was empty - I could sit wherever I wanted. I chose to sit in the middle of the sixth row. I remember thinking, that I’d never watched a movie being the only visitor in an empty movie theatre. I was ready to enjoy the moment, while a guy came in unexpectedly, a moment later - a girl. That ‘s OK, I thought, they should sit in the last row. They stood next to the entrance. The guy viewed over the auditorium, a moment after – he did hurry to take a seat ... next to me ... in an empty auditorium. I was so surprised, I didn’t say anything, I just smiled with my eyes, while looking at the screen. The girl approached and quietly sat next to him.
“Senasis trestas” [The Old Trust] is the name of that movie theatre. Where court hearings are being held today; once three strangers watched a serious movie there, seated in an old-fashioned chair, in an empty auditorium, next to each other. ”(2020)
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<urn:uuid:0854aed9-cb84-4285-8334-abcd781e516a>
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CC-MAIN-2022-33
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https://www.atmintiesvietos.lt/en/sites-of-memory/movie-theatre-senasis-trestas-the-old-trust/
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en
| 0.972423
| 753
| 1.617188
| 2
|
Poll Watcher Information
Poll Watcher Information
Number: In Primary Elections, each candidate may have a single watcher in the voting place. In General Elections there may be only one watcher for each party or organization having nominees.
Appointment: In Primary Elections, a watcher must have a written appointment signed by a candidate. In General Elections, a watcher must have a written appointment signed by a designated representative of a political party. The watcher should surrender this appointment certificate to the Inspector for as long as he remains in the poll. If he plans to visit another precinct, he should ask that the certificate be returned so that he may present it to the next Inspector.
Oath: The watcher shall be sworn to faithfully observe the rule of law prescribed for the conduct of elections. Poll watchers do not have to be present before 7:00 A.M. in order to be sworn in to serve as a poll watcher, but should be promptly sworn in by the Inspector upon his or her arrival and presentation of the appropriate credentials. The Oath may be found on the back of the poll list.....the poll watcher would then be asked to sign under the oath.
Privileges: Generally speaking, poll watchers are allowed to inspect and observe all aspects of a poll’s operation. This includes, but is not limited to, observing the check-in process at the registration table, the execution of the poll list by voters, the distribution of ballots to voters, the circumstances relating to a provisional ballot, the circumstances relating to a spoiled ballot, checking the number of ballots registered on a ballot counter, verifying the total number of signatures on a poll list, and observing the vote tallying process at the end of the election day. However, poll watchers may not interfere with or impede the voting process.
- Poll watchers must not disturb or attempt to influence voters, campaign, or electioneer. They must not display buttons or other campaign materials for any candidate or cause.
- Poll watchers may not act as election officials.
In this Section
Military and Overseas Voting Information
If you are on active duty in the United States Military or you have a family member on active duty or you are a U.S. citizen residing outside of the United States, please click here to learn additional information about your voting rights on the Secretary of State's website on Absentee Voting by Military and Citizens Overseas.
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<urn:uuid:379079bd-1e07-43c4-9748-ce8d7a8551ef>
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CC-MAIN-2022-33
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https://probate.mobilecountyal.gov/elections/poll-watcher-information
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en
| 0.94895
| 500
| 1.6875
| 2
|
What has happened?
The EU Parliament believes that small businesses could benefit from integrating blockchain technology.
What does this mean?
The Industry, Research and Energy Committee has approved recommendations on how to apply the blockchain model to other areas than cryptocurrency, in order to cut intermediation costs for small firms and empower citizens.
The committee also hopes that this will also enable the EU to become a global leader in the blockchain field.
In a press release, the committee said:
"Citizens could use blockchains to gain full control of their own data and decide what to share, and small firms and innovative start-ups could use them to cut intermediation costs and ensure that transactions are executed efficiently, the approved text says."
Areas that would particularly benefit include energy consumption, healthcare, supply chains, transport, finance and the creative industries.
In particular, the committee said that blockchain could be used to:
- monitor the origin of goods, offering greater certainty that, e.g., diamonds are ethically sourced, clothes are not made in sweatshops and a bottle of champagne comes from Champagne,
- “democratise” the energy market, by enabling households that produce energy to exchange and consume it without the need to pay an intermediary agency; and
- create records such as land registries, birth certificates and business licences with less dependence on lawyers, notaries and government officials.
The release states that committee members called on the EU Commission to set regulatory rules for blockchains and other distributed ledger technologies that are "innovation-friendly and technology neutral".
They also asked to include funding for emerging blockchain research and projects in the post-2020 EU long-term budget.
In addition, the committee also approved an oral question to be posted to the EU Commission about blockchain during a plenary session next month.
Rapporteur Eva Kaili said:
"Today the Industry Committee voted univocally in favour of a forward-looking technology that we expect to change the quality of our life, empower SMEs and improve business models in most industrial sectors. Blockchain is a cutting-edge technology and we aspire to make EU the global leader in the era of the Fourth Industrial Revolution".
If you want to take advantage of blockchain's huge potential and disruptive impact, while avoiding falling foul of ever-developing regulatory and legal requirements, visit our Hogan Lovells Engage Blockchain Toolkit.
Receive free news and analysis – written by Hogan Lovells' world-leading legal teams and tailored to your preferences – by registering on Engage. You can also access our cutting-edge interactive Lawtech tools, designed to help you make better decisions and save time and money.
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How many calories are in one piece of white bread?
How many calories are in a small slice of white bread?
With a slice of wholemeal bread containing only 76 calories and 0.9 grams of fat, and a slice of white bread providing only 77 calories and 0.6g of fat, eating bread will not make you fat.
How many calories are in a slice of bread?
Low in Essential Nutrients
|White bread||Whole-wheat bread|
|Serving size||1 slice (25 grams)||1 thin slice (33 grams)|
|Total fat||1 gram||2 grams|
|Carbs||13 grams||17 grams|
How many calories are in a slice of white bread with margarine?
An average slice of white bread with a medium spread of butter has 165 calories . Depending on how generous you are with your spreading, and how hard your butter or margarine is, choose the appropriate number of grams for your spread.
Which bread is best for weight loss?
The 7 Healthiest Types of Bread Sprouted whole grain . Sprouted bread is made from whole grains that have started to sprout from exposure to heat and moisture. Sourdough. 100% whole wheat . Oat bread . Flax bread. 100% sprouted rye bread. Healthy gluten-free bread.
Is white bread good for weight loss?
In one study, people on a lower-calorie diet that included whole grains, such as whole wheat bread , lost more belly fat than those who ate only refined grains, such as white bread and white rice. Whole grains provide more vitamins, minerals, and fiber than refined. But overdoing whole wheat bread can add pounds, too.
Does white bread make you fat?
New research shows what many health experts have long said. It’s not carbohydrates, per se, that lead to weight gain, but the type of carbs eaten. Their research shows that people who ate more refined and processed foods, such as white bread and white rice, had more belly fat .
Why is white bread unhealthy?
The highly processed flour and additives in white , packaged bread can make it unhealthful. Consuming too much white bread can contribute to obesity, heart disease, and diabetes. However, buying bread with the word “whole” as the first ingredient still does not guarantee a healthful product.
Which is the healthiest white bread?
The 3 White-Bread Brands Rebecca Supports Arnold Country White: “As far as plain, old-fashioned white breads go, this one isn’t a bad choice. Alvarado Street Bakery Sprouted White Bread: “Because the first ingredient in this bread is sprouted wheat berries, it contains five grams of protein and three grams of fiber .
Does toasting bread reduce calories?
That said, the European Journal of Clinical Nutrition found toasting bread does have one health benefit. It lowers the glycemic index, so it is less likely than regular bread to spike blood sugar. Toasting bread does not lower calorie count. If you want to toast your bread , lightly toast it.
How many slices of bread should you eat a day to lose weight?
The vast majority of the evidence supports the latest US Dietary Guidelines, which state that a “healthy” 1,800-to-2,000-calorie diet could include six slices of bread a day —including up to three slices of “refined-grain” white bread .
Which bread is the lowest in calories?
Low-Calorie Bread Choices Arnold Bakery Light 100% Whole Wheat Bread : 40 calories per slice. Nature’s Own Wheat Bread : 40 calories per slice. Pepperidge Farm Light Style Bread: 45 calories per slice.
How many calories in 2 slices toast with butter?
Butter on toast: 116 calories .
How many calories should I eat to lose weight?
They require an average of 2,800 calories per day to maintain their weight and up to 3,000 if they’re active. To lose 1 pound (0.45 kg) per week, moderately active young men should consume 2,300–2,500 calories daily. Energy needs decrease as men age.
Is toast and eggs healthy?
Poached or scrambled eggs served on wholegrain toast with grilled tomatoes tops Rob’s healthiest breakfasts list. He said: ‘ Eggs are the ultimate breakfast food for me. ‘They’re high in protein and nutrients, such as the B vitamins, which convert food into energy within the body.
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investments in climate smart agri tech to help farmers to prevent burden
of climate change
- Set-up a BRICS Venture Fund for Women Run Digital Companies under the aegis of New Development Bank
NEW DELHI, 11 September 2021: BRICS Women's Business Alliance Annual Report 2021, released earlier this week highlights key areas to increase women participation in the economy. These areas include Inclusive economy; Healthcare; Innovative Development; Food security and Environmental Safety; Creative Industries and Tourism; Public Policy.
The BRICS Women's Business Alliance (BRICS WBA) officially launched its activities in July 2020 under Russian BRICS Chairmanship with the objective of offering a platform to promote women's economic participation and empowerment by unlocking business opportunities for women entrepreneurs in BRICS countries. BRICS WBA comprises 25 Women Leaders, 5 each nominated from BRICS countries.
Key highlights of the Report:
First: Access to credit is a major pain point for women entrepreneurs. Setting up of a Credit Guarantee Fund under the aegis of BRICS with the objective to provide a corpus for agile, tech savvy financial institutions, to enable them to structure new products focused on women entrepreneurs particularly in rural areas.
Second: Access to credit is related to financial literacy. A financial literacy virtual tool kit is being created, designed for NGOs, SHGs and social change agents to train rural women and small entrepreneurs to help them strengthen their business management, capability and growth.
Third: Importance of Care Economy has increased manifold in the aftermath of COVID pandemic. The sector, given its dominance by women, is an important area of collaboration amongst BRICS especially through knowledge sharing of best practices for care work - including technological and digital solutions, training and upskilling, labour regulations and harmonization and recognition of degrees and diplomas.
Fourth: The pandemic brought 'Healthcare' at the center-stage. Deepening BRICS collaboration for digital transformation of the entire healthcare ecosystem as well as focus on point of care and remote care through enhanced usage of new technologies like Artificial Intelligence and Big Data, as well as establishing Command-Centres, towards patient centered healthcare delivery have been captured.
Fifth: Promote investments in climate smart agriculture technologies, set research priorities and develop efficient extension services for adoption of agronomic practices that can empower farmers to prevent the burden of climate change impact. Future research to mitigate climate change impact and adapt to low-carbon and low-water regimes.
Sixth: Set-up a BRICS Venture Fund for Women Run Digital Companies under the aegis of New Development Bank. Currently, many women in the process of driving innovation do not receive funding because of limited access and collateral.
Within the Alliance, five key areas of focus include inclusive economy, healthcare, innovative development, food security & environmental safety and creative industries & tourism.
Amongst other areas, BRICS Women's Business Alliance is also discussing 'BRICS Centre for Arbitration and Dispute Resolution and BRICS Energy Initiative' for improving participation of women led businesses across the Energy Value Chain. Further, a digital knowledge centre for women entrepreneurs is being planned.
According to the World Economic Forum's Global Gender Gap Report 2021, as the impact of the COVID-19 pandemic continues to be felt, closing the global gender gap has increased by a generation from 99.5 years to 135.6 years. This means that we need to work harder as the challenge facing us is enormous.
FICCI MEDIA DIVISION
Leave your Comment
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Wednesday, August 10, 2022
“Your beliefs do not make something true."
(Judge Maya Guerra Gamble to Alex Jones at his trial for defamation, at which he was ordered to pay millions of dollars for falsely claiming that the Sandy Hook shootings did not happen and that parents of the victims were actors.)
Tuesday, August 09, 2022
Today, the NHS delivered the first milestone in the Elective Recovery Plan, virtually eliminating the longest treatment waits. There is a long way to go to resolve the backlogs that have inevitably built up during Covid, but progress is being made to do so and the plan is on track.
- Today the first phase of the plan was successfully delivered, treating more than 22,500 people who had been waiting over two years for treatment to virtually eliminate longest treatment waits; and preventing a further 51,000 patients from waiting two years or more thanks to the hard work of our NHS staff.
- Beating the Covid backlog is one of the government's top priorities and this achievement is a testament to NHS staff who have worked incredibly hard to get us here despite the significant challenges.
It's been a really bad few days for the loss of favourite singers and performers.
First Bernard Cribbins died, then Judith Durham, and now within a few hours we lose Olivia Newton-John and The Pogues' bass player Darryl Hunt dies age 72.
Olivia Newton-John was born in Cambridge on 26 September 1948. Her Welsh father had been an MI5 agent during World War II and had been attached to the Enigma code-breaking project at Bletchley Park.
Her mother was the daughter of the German Nobel laureate, Max Born, and had fled with her family when the Nazis came to power in 193.
In 1954 her father took up a post as a professor of German at the University of Melbourne and the family moved to Australia.
As a child Newton-John had developed a fascination with animals and harboured ambitions to be a vet but she found science a struggle at school and abandoned the idea.
Instead, she turned to music.
She began her career as a singer of country-style pop-music, but her breakthrough performance, and a complete image makeover, came with her performance as Sandy in the 1978 film "Grease." For anyone who hasn't seen the film, the character Sandy starts off as a demure young lady in twinsets and calf-length skirts, but then transforms into an electrifying sex bomb in black skin-tight trousers.
Released in 1978 and set 20 years earlier, Grease was an immediate hit, taking $160m at the box office and becoming an international phenomenon. It was the highest grossing musical movie of the 20th Century, and gave Newton-John three hit singles, You're The One That I Want, Hopelessly Devoted to You and Summer Nights as well as a Golden Globe nomination for Best Actress.
After being diagnosed with breast cancer, Newton-John reinvented herself again. She spent more of her time as an advocate of humanitarian and health issues. She had already established herself as a campaigner for animal welfare, cancelling a tour of Japan in 1978 as a protest against the slaughter of dolphins caught in tuna nets.
She was a supporter of cancer charities, something that led to the opening of the Olivia Newton-John Cancer & Wellness Centre in Melbourne.
She continued to record although many of her subsequent albums were only released in Australia where she performed at the opening of the Sydney Olympics in 2000.
In 2019 her legendary tight black trousers and leather jacket from Grease were auctioned for $405,000.
In line with her wishes, the proceeds were donated to Australian cancer research.
Her efforts in the field of fundraising for cancer research were recognised by the Queen, who honoured her with a damehood in the 2020 New Year's Honours list.
In a statement posted to her social media channels, Newton-John's husband John Easterling said she had died on Monday, hailing her "a symbol of triumphs and hope for over 30 years, sharing her journey with breast cancer".
"Her healing inspiration and pioneering experience with plant medicine continues with the Olivia Newton-John Foundation Fund, dedicated to researching plant medicine and cancer."
Rest in Peace
Monday, August 08, 2022
Today the Health Secretary set out what steps his Department is taking to prepare our NHS for the autumn and winter months ahead – ensuring that our NHS is ready and prepared for upcoming challenges so that everyone gets the care they deserve.
- The autumn and winter months always bring additional challenges for our NHS, and we all know that the next few months in particular will bring serious challenges.
- So I was pleased to see that the Health Secretary has set out today how his Department is preparing for the autumn and winter months, including boosting the NHS workforce, addressing delayed discharge and working on a ‘pharmacy first’ model to help ease pressure on our hospitals’.
- The government is taking action now to prepare for the upcoming months to ensure everyone can access the health and care services they need and deserve.
As the Commonwealth Games in Birmingham come to an end today, the Prime Minister has thanked all those involved in putting on this extraordinary event – the legacy of which will drive trade, jobs and grows across the West Midlands for years to come.
- Over the past eleven days, volunteers, crowds, athletes and organisers made the Commonwealth Games in Birmingham the best yet.
- The Prime Minister has thanked all those involved and particularly praised the city of Birmingham for being fantastic hosts – cementing the UK’s reputation for hosting major sporting events on the global stage. The success of Birmingham 2022 will also be measured in the number of people inspired to take up sport as a result – able to do so thanks to our massive investment in grassroots sport in recent years.
- The people of the West Midlands will reap the rewards from the lasting economic legacy these Games have secured that will drive trade, jobs and growth across the region for a generation to come.
The government has tightened council accounting rules, ensuring councils use hardworking taxpayers’ money in a responsible way.
- For too long, some councils have been using unorthodox accounting practices which put hardworking taxpayers’ money at risk.
- That is why the government has tightened the rules on use of capital receipts which some authorities have attempted to bypass, as well as putting a stop to accounting firms and consultancies wasting money on creative accounting practices.
- Every council has a duty to use the tax they receive from hardworking people in a responsible way, and we will continue to do all we can to put a stop to practices which put this at risk.
Last week the government announced a £100 million funding boost to research sustainable fisheries practices, equipping our fishing industry for the future.
- Our world-class fishing and seafood sectors are packed full of expertise – but we must continue to ensure these excellent schemes have the financial backing to succeed.
- That is why the government is investing £100 million of taxpayers' money through the UK Seafood Fund to research ground-breaking sustainable fisheries practices, delivering 17 pioneering projects to promote the sustainable management of our world-class fisheries.
- This investment will not only cement our fishing industry’s reputation as one of the best in the world but will elevate its potential even further.
Following on from my article last night about Moscow and Amnesty, I thought it would provide some helpful balance after the extensive and selective quoting of what Amnesty wrote suggesting that Ukrainian troops had been posted in residential areas, if I were to quote some of the things Amnesty International has also written about war crimes and human rights violations by Russia.
"The invasion has triggered a huge human rights, humanitarian, & displacement crisis that has the makings of the worst such catastrophe in recent European history. Russia is breaching the sovereignty of Ukraine & challenging the global security architecture."
Agnes Callamard, Secretary General of Amnesty International.
"The people of Kharkiv have faced a relentless barrage of indiscriminate attacks in recent months, which killed and injured hundreds of civilians"
Donatella Rovera, Amnesty International’s Senior Crisis Response Adviser
"This attack is yet another example of the Russian military’s utter disregard for civilians in Ukraine."
Donatella Rovera, Amnesty International’s Senior Crisis Response Adviser, comments on Russian air strikes on an apartment block and beach resort hotel in the coastal town of Serhiivka in southern Ukraine which killed at least 21 civilians, following an on-the-ground investigation.
"The International Criminal Court, and all others with jurisdiction over crimes committed during this conflict, must investigate this attack as a war crime."
Agnès Callamard, Amnesty International’s Secretary General, commenting after an extensive investigation by Amnesty International concluded that Russian military forces committed a war crime when they struck the Mariupol drama theatre in Ukraine in March, killing at least dozen people and likely many more.
“This horrific assault is yet another apparent example of complete disregard for human life and dignity in Ukraine committed by Russian forces. All those suspected of criminal responsibility must be investigated and, if there is sufficient admissible evidence, prosecuted in fair trials before ordinary civilian courts and without recourse to death penalty.
“Since the start of Russia’s war on Ukraine, Amnesty International has documented crimes under international law, like summary killings of captives by Russia-backed separatist forces in eastern Ukraine and extrajudicial executions of Ukrainian civilians by Russian forces.
“International law is clear: prisoners of war must not be subjected to any form of torture or ill-treatment, and should be given immediate access to the International Committee of the Red Cross. The relevant authorities must fully respect the rights of prisoners of war in accordance with the Geneva Conventions.”
Marie Struthers, Amnesty International’s Eastern Europe and Central Asia Director, responds to a video which appears to show Russian solders committing a hideous atrocity against a Ukrainian prisoner of war.
“This is a blatant violation of international humanitarian law on so many counts.
“The three were members of the Ukrainian regular forces and under the Geneva Conventions, as prisoners of war, they are protected from prosecution for taking part in hostilities. The only exception is prosecution for alleged war crimes, in which case there must be sufficient admissible evidence, and fair trial standards must be ensured. Not only this is not the case in this scenario – they were not tried by an independent, impartial regularly constituted court but by Russian proxies. The so-called ‘charges’ against them would not constitute war crimes. And most outrageously of all, the taking of their lives as result of the grossly unfair proceedings would constitute arbitrary deprivation of life.
“In fact, wilfully depriving a prisoner of war or other protected person of the right to a fair and regular trial constitutes a war crime. Russia, as the occupying power, bears responsibility for the treatment of all prisoners of war and others deprived of their liberty. They must ensure this so-called ‘sentence’ is immediately quashed, and that these men are treated in full compliance with international humanitarian law.”
Denis Krivosheev, Amnesty International’s Deputy Director for Eastern Europe and Central Asia, responding to the news that a separatist “court” in Russia-occupied Donetsk ordered the death of two captured two British nationals and a captured Moroccan national.
"As thousands of protesters take to the streets across Russia to denounce the war, the Kremlin remains hellbent on stifling state critics as it coerces domestic media into supporting its policies"
Marie Struthers, Amnesty International’s Eastern Europe and Central Asia Director
Sunday, August 07, 2022
Coverage over the last few days in both the MSM and on social media of what Amnesty International has written about the war in Ukraine has been astonishingly selective in a way which has been unwittingly helpful to Russian propagandists.
I understand that since the start of Putin's illegal invasion of Ukraine, Amnesty has published about forty reports into the war. And that all forty of those reports have been severely critical of Russia's actions. Thirty nine of these reports condemned just Russia. One report, published a few days ago, included criticism of both sides, though perhaps unwisely it was headlined "Ukrainian fighting tactics endanger civilians."
I share some of the concerns which have been expressed by Ukrainian representatives from President Zelenskiyy downwards about this report. It is not surprising that Russian propagandists have selectively quoted it to bring out the criticisms Amnesty International made about the Ukrainian military while ignoring the far more serious criticisms Amnesty has also made about the Russian government and military.
However, I think it is important that we do not allow Russia to establish the false narrative that Amnesty has been critical of Ukraine's actions and not been far more critical of Russia's.
Even if we just looked at the recent report which included criticism of Ukraine, Amnesty also said in that report that the Ukrainian tactics of which it is critical, quote,
"in no way justify Russia’s indiscriminate attacks, which have killed and injured countless civilians."
Amnesty International wrote that in parts of Ukraine in which, quote,
"Amnesty International concluded that Russia had committed war crimes, including in some areas of the city of Kharkiv, the organization did not find evidence of Ukrainian forces located in the civilian areas unlawfully targeted by the Russian military".
The Amnesty international report also refers to, quote,
"Indiscriminate attacks by Russian forces
Many of the Russian strikes that Amnesty International documented in recent months were carried out with inherently indiscriminate weapons, including internationally banned cluster munitions, or with other explosive weapons with wide area effects."
Amnesty International has published plenty of other reports which are unequivocally critical of Russia's war crimes during the illegal invasion of Ukraine - which Amnesty describes in exactly those terms.
Amnesty calls "Russia's War on Ukraine," quote,
"a devastating human rights crisis," adding
"Right now, people in Ukraine are facing a human rights crisis. People are dying, including children, and many more are at risk.
As Russia continues its war against Ukraine, Amnesty International is exposing violations of human rights and international humanitarian law, and gathering evidence from our researchers on the ground and our Crisis Evidence Lab. From the devastation of Izium to the siege of Mariupol, from shelling in Kyiv to displaced people in Lviv, we’re helping to keep the world informed about what is happening in Ukraine.
Russian President Vladimir Putin, his government and the Russian armed forces are desperate to hide the truth about the war, including the possible war crimes they are committing in Ukraine."
Now, given Russia's track record of using and abusing any information it can to play into false narratives I do think that Amnesty International was very unwise to risk allowing their work to be misrepresented by Russian propagandists, as it sadly has been, and has a duty to be more vigorous than they have yet been in rebutting such false narratives.
Sadly, Amnesty has form for falling into this kind of Russian trap, as they did last year over the jailed Russian opposition leader and survivor of an attempted state Russian assassination attempt, Alexei Navalny.
Russia, on the other hand, has form for attacking hospitals which are full of patients and doctors and were not occupied by Ukrainian military personnel, and then publishing propaganda falsely claiming the hospitals concerned were no longer in use as medical facilities but had been taken over by Ukrainian military units and imaginary Nazis.
Anyone reporting or commenting on the war in Ukraine has a moral duty and a duty to the truth to bend over backwards to avoid publishing anything which can be abused to play into such false narratives.
The truth is that most Ukrainian military units who are in or near residential areas are there because Russian forces are attacking those areas.
In Putin's illegal war, one side, Russia, is the aggressor and the other side, Ukraine, is the victim, and there is no moral equivalence between them.
In every war there will be mistakes and atrocities on both sides, and those responsible on each side must be held to account. But the current war is a war between good and evil, and there have been far more atrocities perpetrated on the Russian side than on that of Ukraine.
Saturday, August 06, 2022
The government has announced an extension in funding for victims and survivors of terrorist attacks, making sure that all victims of terrorism can continue to access support services.
- This year marks the fifth anniversary of several horrific terrorist attacks that took place in 2017 and we are all coming to recognise that victims can be affected in more ways than many of us could ever contemplate.
- So the government is extending funding to Cruse Bereavement Support, the Peace Foundation, South London and Maudsley NHS Foundation Trust, and Victim Support – providing 24/7 support lines, mental health assessments and referrals, bereavement support, and long-term peer support networks.
- This funding will make sure those affected by terrorist attacks can be provided with practical and emotional support to work through these traumatic events, and continue to access support services for as long as they need them.
"Know we're not allowed to ask this. But given Labour are saying the Tories have let inflation spiral out of control, what's their proposal?
They don't support wage restraint.
They oppose the interest rate rises.
They don't back public spending cuts.
They oppose tax hikes."
(Dan Hodges,journalist and former Labour and Trade Union staffer, on Twitter yesterday.
It's a rather good question, isn't it. At least Rishi and Liz are putting forward proposals. What would Labour actually do if they won an election?)
Friday, August 05, 2022
In May Laura Castle was sentenced to 18 years in prison for the murder of Leiland-James Corkill, a one-year-old boy who had been placed with her and her husband in a pre-adoption placement by Cumbria Council council.
The council's executive director John Readman provided a public statement on behalf of the council at the time, including an apology for Leiland-James’ death.
"Adoption should have been a new beginning for Leiland," he said.
"That was cruelly taken away from him by the person who should have cared for him and kept him safe.
"We are deeply sorry for Leiland's death, it should not have happened.
"Our thoughts and sympathies are with his birth family and all those who knew this little boy.
"Abuse of a child by adopters is almost unheard of and we are determined to do everything we can to prevent this happening again, here or anywhere else."
The independent Best Practice Review into the case has now been published and is available on the Safeguarding Children Partnership website at
The information that has come out through the trial and this report was shocking and distressing.
I believe that we need a task and finish group of the Council's scrutiny committees to go through this report and ensure that all the lessons it identifies have been learned and fully implemented.
After tragedies like this politicians always say things like "This must never happen again," which is the right thing to aim for, but far too often it still does. Let's do what we can to make sure this is not one of those times.
"The main pressure is external ... but we've got another thing going on that is domestic: the size of the labour force has shrunk ... The first thing that every firm wants to talk to me about is 'I can't hire enough people'."
The above is a quote from the Bank of England Governor Andrew Bailey in an interview this week.
This is why the most urgent task for whoever becomes PM in a month's time is to sort out Britain's long-term problem of anaemic growth in productivity. There is no simple solution to this and neither left nor right have all the answers, which are likely to include more investment - and therefore decent returns on investment - more imaginative management, fewer restrictive labour practices and, most difficult of all, genuine reform of the housing market which should feature both a better planning balance which allows more houses to be built where they are needed but with the necessary supporting infrastructure, and making it less of a nightmare to buy or sell a property.
Members of the Allerdale and Copeland local committees of Cumbria County Council have been listening to a presentation this morning of the refugees from troubled areas over the world who have come to Cumbria, from Syria and Afghanistan to Ukraine, and about how they are supported.
It took a while to get off the ground, from which we need to learn lessons, but now more than 100,000 Ukrainians have arrived in the UK through our Family Scheme and Homes for Ukraine sponsorship scheme.
Thank you to everyone across the UK who has opened their home to those forced to flee Ukraine due to Putin's barbarism.
Are any of the offences of which the leader of the opposition has just been found serious enough that a reasonable person would call for Sir Keir's resignation?
In my opinion no, so I'm not.
Are all of them more serious than some of the things for which Sir Keir called for Boris Johnson's resignation? Absolutely yes.
It is a matter of objective fact that if Sir Keir held himself to the same standards he demanded of the current PM, he would have resigned months ago.
So while I am not calling for his resignation, I do think it is fair to call him a sanctimonious hypocrite.
Today the government has announced £44.2 million in funding for community forests, planting millions of trees to expand woodlands near to where people live, giving more people greater access to nature to improve their health and wellbeing.
- Our economies, livelihoods and wellbeing all rely on nature – community forests and woodland improves the lives of communities and provides the green infrastructure needed to support regional growth.
- That is why the government is investing £44.2 million of taxpayers' money in planting 2,300 hectares of trees, the equivalent of 3,220 football pitches – to absorb 600,000 tonnes of carbon dioxide by 2050, delivering on our ambition to treble tree planting by the end of this Parliament and reach Net Zero.
- This is good use of taxpayers' money because it will reduce flood risk, provide sustainable UK grown timber, greater access to nature to improve health and wellbeing, and create more green jobs – helping spread economic growth across the country.
Thursday, August 04, 2022
The government has announced a £37 million funding boost for renewable energy innovation across the UK, securing our energy sovereignty and slashing our dependency on fossil fuels for years to come.
- The rise in global gas prices and Putin’s war in Ukraine means securing the UK’s energy sovereignty is more pressing than ever – and accelerating home-grown renewables is central to that mission.
- That is why the government have announced £37 million for innovative biomass projects across the UK – including 12 projects off the North Yorkshire coast and announcing the 22 winners of the first stage of our Hydrogen bioenergy with carbon capture and storage programme, backed with £5 million
- This £37 million of investment is good use of taxpayers' money as it will support innovation across the UK, boosting jobs whilst ensuring greater energy security for years to come.
- And yes, it important to remember that all government money is in fact taxpayers' money - it comes from all of us.
Wednesday, August 03, 2022
Society makes progress in dealing with mental health but it can be painfully slow.
Three or four hundred years ago those who suffered certain types of mental illness faced a real danger of being hanged as witches or tortured and mutilated by the public executioner for blasphemy.
Two hundred years ago you could go to certain of the most infamous of the places where people with mental illness were confined and pay to "torment" the inmates.
One hundred years ago, while the treatment had become slightly more compassionate, society still wanted to put away out of sight those it had labelled as insane and lock them away in huge institutions in the countryside - sometimes not for any real mental illness but as a way of removing from public view people who had committed social misdemeanors. Women who bore a child out of wedlock, or someone from a wealthy family who was caught shoplifting might be labelled as insane and packed off to a sanatorium. The penalty could be more severe than the criminal justice system of the early 20th century would have imposed - as it could effectively be life imprisonment.
When I was appointed as a health authority member in the late 1980's there were still a few elderly women, now institutionalized beyond hope of discharge, in some of the mental health hospitals in the area who had been sent there for bearing an illegitimate child.
By that time the NHS was moving towards "care in the community" which is a policy which I strongly supported then and now as long as it does mean care and not, as has occasionally happened here and in other countries, chucking people out of the front door without a proper package of care in place. But there was real resistance at the time from people who assumed anyone with mental issues is dangerous. A very small proportion of mental health patients really are dangerous, and society needs to be protected from them, but most are not.
We continue to move forward, but there is still a stigma about mental health which makes it difficult for many people suffering from stress, depression or other such conditions to seek help, and although governments of all parties say they want mental health to be taken as seriously as physical health, we are some way off achieving this.
The local newspapers picked up some comments I and others made on the subject at the last Health Scrutiny meeting - you can read their report of the meeting in the online version of the Whitehaven News at
Tuesday, August 02, 2022
Better energy efficiency is both a means of protecting the environment and a means of helping everyone - including public services such as schools and hospitals - cope with higher energy bills.
So the government is setting up a fund of up to £635 million to help our public services deal with high gas prices – helping to save taxpayer’s money and protect those public services.
- There is no time like the present to help public organisations become more efficient and move off expensive gas.
- That is why we have announced an investment of up to £635 million for public buildings such as schools and hospitals to invest in energy efficiency upgrades.
- This investment is an important step towards making our public sector more efficient – saving taxpayer’s money, creating tens of thousands of jobs and cutting our link to expensive gas.
"Jesus told us you'd better think of the beam in your own eye before judging other people. And that's been my attitude ... I don't like judging people if I can avoid it."
(Lord Mackay of Clashfern, former Lord Chancellor, from an interview in the Sunday Times magazine last weekend as he steps down from the House of Lords. If you are willing to get through the paywall - they are offering a free trial - you can find the interview here.)
Monday, August 01, 2022
The government is creating a Levelling Up Parks Fund – creating new and improved parks in urban areas as part of the project to level up our communities.
- Access to nature provides sanctuary from the bustling streets of our towns and cities, and is good for our health and wellbeing - so it is right that we upgrade and improve these spaces.
- That is why we have announced our Levelling Up Parks Fund – creating or improving over 100 new and improved green spaces in areas such as Liverpool, Birmingham, Carlisle, as well as Scotland, Wales, and Northern Ireland – backed by an investment of £9 million.
- This funding will ensure that people from all backgrounds have access to nature while supporting tree planting within public spaces in our urban communities.
Today the government announced that the £368 million Youth Investment Fund has opened for bids to local authorities – improving the health, wellbeing and career prospects for young people as we level up opportunity.
- Ensuring young people can succeed – regardless of where they are born – is central to our levelling up agenda, and we are determined to ensure nobody is left behind.
- That is why our £368 million Youth Investment Fund opened for bids in 46 local authorities and more than 600 district wards in some of England’s most deprived areas, helping to build or refurbish up to 300 youth facilities as safe spaces to socialise and help support them into employment.
- These opportunities will help local young people develop the skills they need for life and work, while improving their wellbeing and employability.
When I previously referred to this comment from American economist Thomas Sowell, in May, I wrote that
"This quote is so true and so utterly relevant to the current state of affairs in public discourse that I am seriously tempted to repost it on a regular basis once per month."
While I don't think it would be effective to do that, I am using it again to inaugurate a new category of Quote of the Month.
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In this course, you will :
- Know how to Critically evaluate the role of management accounting information and related ethical issues in planning, organizing, and controlling activities of a firm.
- Know how to Contrast different cost types, classifications, and methods and apply this knowledge in decision-making process.
- Know how to perform Cost-Volume-Profit analysis for profit planning, pricing decisions, and sensitivity analysis.
- Know how to Prepare and explain the use of Incremental Analysis in the decision-making process.
- Know how to Create excel spreadsheets to interpret budgets as part of responsibility accounting.
- Know what a job costing system, a process costing system and an activity based Costing system operates..
- Understand the target pricing model..
- Learn how to use the incremental analysis technique when analyzing problems and decision making..
- Prepare a master budget using excel.
- Understand the Balanced Scorecard..
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Healthcare Industry News: HSMN NewsFeed
News Release - June 17, 2021
Lilly Launches Think Talk Treat Migraine(TM) to Help Improve Diagnosis and Treatment of MigraineThink Talk Treat Migraine empowers people living with migraine and their primary care providers (PCPs) to have more direct conversations that can improve diagnosis and care
INDIANAPOLIS, June 17, 2021 -- (Healthcare Sales & Marketing Network) -- Based on results from a large population-based survey, it is estimated that approximately half of people with migraine hesitate to seek care for a variety of reasons, and even fewer receive a diagnosis and take the treatment they need.1,2,3 To help address these important unmet needs in migraine care, Eli Lilly and Company (NYSE: LLY) launched Think Talk Treat Migraine™, a new initiative to empower people living with migraine and their primary care providers to recognize key symptoms of migraine and have better conversations about the disease that can lead to proper diagnosis and treatment.
The initiative is currently in pilot stage – available in four metropolitan areas – Hartford/New Haven (Connecticut), Raleigh/Durham (North Carolina), Indianapolis (Indiana) and Denver (Colorado) – and provides people living with migraine and their healthcare providers with simple resources to think about, talk about and treat migraine.
"People with significant disabling headache often do not recognize it as migraine and as a result, understandably do not seek care. Further, among those who do seek care, there is often a gap in communication between them and their primary care provider, particularly about the impact migraine has on their life. This can not only lead to fewer appropriate diagnoses, but also treatment recommendations that may not deliver the freedom from migraine pain they seek," said Michael Cobas Meyer, MD, MBA, vice president of global medical affairs, Lilly Bio-Medicines. "The goal of Think Talk Treat Migraine is to simplify the recognition and discussion of the disease from both the patient and the primary care provider perspectives, potentially leading to meaningful improvements in health outcomes through accurate diagnosis and appropriate, timely care."
More people impacted by migraine seek care from a primary care provider than any other care setting,4 yet research shows that only a small proportion receive a migraine diagnosis and treatment recommendation during those initial discussions.5 There can be many reasons for this including the short length of an office visit or the ability to effectively convey or recognize symptoms.6 While 40% of people with migraine are eligible for preventive treatment, less than 20% receive it.7 Further, only 28% of people impacted by migraine and eligible for acute treatment are seeking care, diagnosed with migraine and prescribed recommended acute medication.3
"I've been living with migraine for most of my adult life and like many others who may be misdiagnosed or undiagnosed, I didn't realize there was a name for what I was experiencing or that it was a neurological disease," said Kelsey V., 27 years old from Colorado. "It's important that initial discussions about migraine with one's health care provider are easier because having the right diagnosis and the right treatment can make all the difference."
Think Talk Treat Migraine provides information, tools and resources specifically developed for people who may be living with migraine and primary care providers, including a Talk To Your Healthcare Provider Checklist, a new digital migraine management platform called VEGA™ and education about the ID Migraine® tool, which helps identify people living with migraine by asking three simple questions:
- Has a headache limited your activities any day in the last month?
- Are you nauseated or sick to your stomach when you have a headache?
- Does light bother you when you have a headache?
VEGA is a digital platform that offers a smartphone app to enable users to track important information about their migraine such as their ability to function, pain severity, symptoms, triggers and the medications they take to manage it. With this information, a person can more effectively talk to their provider about the impact migraine has on their life, which may help inform an appropriate treatment plan.
Think Talk Treat Migraine will also host webinars for primary care providers to help elevate awareness of migraine within the primary care setting. Information provided during the webinars will focus on a streamlined approach to help identify migraine, information about how to assess the impact of migraine and insights about how the extent of impact a migraine has can inform an appropriate treatment plan.
"Despite its prevalence and the human and societal impact of migraine, this disease is often underestimated and misunderstood. A variety of reasons, including stigma and lack of awareness, drive some people living with migraine to hide their pain and the effects of the disease. This can lead to underdiagnoses and unnecessary pain and disability," said Kevin Lenaburg, executive director, Coalition for Headache and Migraine Patients (CHAMP). "Lilly understands the impact that not getting an accurate diagnosis can have on people living with migraine and recognizes that it doesn't have to be that way. Think Talk Treat Migraine is fostering important conversations while providing the tools and resources to help make a meaningful difference for people with migraine and primary care providers alike."
Migraine is a severely disabling neurologic disease characterized by recurrent episodes of moderate to severe headache accompanied by other symptoms including nausea, sensitivity to light, and sensitivity to sound.9,10 More than 30 million American adults have migraine, with three times more women than men affected by migraine.7 Migraine is often incapacitating, leading to high personal, societal, and economic burden. According to the Medical Expenditures Panel Survey, total annual healthcare costs associated with migraine are estimated to be as high as $56 billion in the United States, yet it remains under-recognized and under-treated.11
About Lilly's Commitment to Headache Disorders
For over 25 years, Lilly has been committed to helping people affected by headache disorders, investigating more than a dozen different compounds for the treatment of migraine and cluster headache. These research programs have accelerated our understanding of these diseases and furthered the advancement of treatments for headache disorders. Our goal is to apply our combined clinical, academic and professional experience to build a research portfolio that delivers broad solutions and addresses the needs of people affected by these disabling neurologic diseases.
About Eli Lilly and Company
Lilly is a global health care leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about Lilly, please visit us at lilly.com and lilly.com/newsroom.
Cautionary Statement Regarding Forward-Looking Statements
This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Lilly's Think Talk Treat Migraine™ Initiative and Lilly's efforts, plans, and objectives, and reflects Lilly's current beliefs and expectations. There can be no assurance that Lilly will be successful in achieving the goals discussed above. For additional information about the factors that could cause actual results to differ materially from forward-looking statements, see Lilly's Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release.
Think Talk Treat Migraine™ and VEGA™ are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. ID Migraine® is a registered trademark of Pfizer Inc.
- Shapiro RE, Nicholson RA, Zagar AJ, Reed ML, Buse DC, Hutchinson S, Ashina S, Lombard LA, Pearlman EM, Lipton RB. et al, Reasons for Hesitating to Consult for Migraine Care: Results of the Observational Survey of the Epidemiology, Treatment and Care of Migraine (U.S.) (OVERCOME) Study. Headache. 2021;61(S1):10-11
- Ashina S, Nicholson RA, Buse DC, Reed ML, Vargas B, Hutchinson S, Samaan K, Zagar A, Kim Y, Pearlman EM, Lipton RB. Identifying barriers to care-seeking, diagnosis, and preventive medication among those with migraine: results of the OVERCOME study. Headache. 2020;60(S1):127-128.
- Nicholson RA, Hutchinson S, Vargas B, Buse DC, Reed ML, Ashina S, Samaan K, Zagar A, Kim Y, Pearlman EM, Lipton RB. Seeking care, diagnosis, and acute prescription for migraine among those with headache-related disability: results of the OVERCOME study. Headache. 2020;60(S1):132-133.
- Burch RC, Loder S, Loder E, Smitherman TA. The prevalence and burden of migraine and severe headache in the United States: updated statistics from government health surveillance studies. Headache. 2015 Jan;55(1):21-34. doi: 10.1111/head.12482. Erratum in: Headache. 2015 Feb;55(2):356. PMID: 25600719.
- Lipton RB, Munjal S, Alam A, Buse DC, Fanning KM, Reed ML, Schwedt TJ, Dodick DW. Migraine in America Symptoms and Treatment (MAST) Study: Baseline Study Methods, Treatment Patterns, and Gender Differences. Headache. 2018 Oct;58(9):1408-1426. doi: 10.1111/head.13407. Epub 2018 Oct 20. PMID: 30341895.
- Martin, VT. 5 great reasons why you, a primary care clinician, should develop additional expertise in the field of headache medicine (AHS). Available at: https://americanheadachesociety.org/wp-content/uploads/2021/01/AHS-First-Contact-5-Reasons-to-get-Headache-Expertise.pdf. Accessed: May 20, 2021.
- Lipton RB, Bigal ME, Diamond M, et al., Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68:343-349.
- Lipton RB, Dodick D, Sadovsky R, Kolodner K, Endicott J, Hettiarachchi J, Harrison W; ID Migraine validation study. A self-administered screener for migraine in primary care: The ID Migraine validation study. Neurology. 2003 Aug 12;61(3):375-82. doi: 10.1212/01.wnl.0000078940.53438.83. PMID: 12913201.
- Katsarava Z, Buse D, Manack A, et al. Defining the differences between episodic migraine and chronic migraine. Current Pain Headache Reports. 2012;16:86.
- Blumenfeld AM, Payne KA, Varon SF, et al. Disability, HRQOL, and resource use amongst chronic and episodic migraineurs. Results from the International Burden of Migraine Study (IBMS). Cephalalgia. 2011;31:301.
- Raval AD, Shah A. National trends in direct health care expenditures among US adults with migraine: 2004 to 2013. Journal of Pain. 2017;57:60.
Source: Eli Lilly
Issuer of this News Release is solely responsible for its
Please address inquiries directly to the issuing company.
Related News ItemsEight out of Ten Patients Maintained Skin Clearance at One Year in Lilly's Lebrikizumab Atopic Dermatitis Monotherapy Trials
Fifty Percent of Patients with Ulcerative Colitis Treated with Mirikizumab Achieved Clinical Remission at One Year in Lilly's Pivotal Phase 3 Study
Lilly Announces the Institute for Genetic Medicine and $700 Million investment in Boston Seaport Site
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Charm Sciences Collaborates with AAA to Verify Sanitation Standards in the Hospitality Industry
Charm’s ATP monitoring system will help verify the cleanliness of hotel facilities.
Charm is proud to announce a collaboration with AAA. Together we will deliver superior sanitation monitoring and verify standards of cleanliness in the hotel industry.
The COVID-19 pandemic is challenging hotels to uphold stricter sanitation and cleaning procedures. In response, hotels are adopting new protocols. However, according to AAA research, 76% of consumers surveyed would be disappointed if a third-party inspection did not evaluate the sanitation of high-touch areas in a hotel.
Charm has trained and certified AAA inspectors to conduct ATP surface testing in hotels to help quantify and measure cleaning efforts. “With the new addition of surface testing, these properties will now also be recognized as Inspected Clean,” said Paula Twidale, Senior Vice President, AAA Travel.
The new Inspected Clean criteria add an objective, scientific validation that the hotel’s cleaning protocols are effective by detecting ATP. ATP (adenosine triphosphate) is an energy-carrying molecule found in all living cells. Most food sources, human skin cells, bacteria, yeast, mold, and biological material found in respiratory droplets contain ATP. Charm Sciences manufactures a bioluminescent test called PocketSwab Plus, to detect ATP as an indicator of surface cleanliness.
AAA inspectors will use the PocketSwab Plus ATP test to swab eight high-touch surfaces. Surfaces may include guest room door handles, tv remotes, or sink faucet handles. In just five seconds, Charm’s novaLUM II-X system detects even the lowest levels of ATP contamination.
With the addition of Charm Sciences’ ATP surface testing to the AAA Diamond Program, AAA will recognize hotels that pass their unannounced inspection as Inspected Clean. Charm Sciences’ ATP monitoring system will help the hospitality industry to verify, quantify, and improve the cleanliness of their facilities.
ABOUT CHARM SCIENCES
Established in 1978 in Greater Boston, Charm Sciences helps protect consumers, manufacturers, and global brands from a variety of issues through the development of food safety, water quality, and environmental diagnostics tests and equipment. Selling directly and through its network of distributors, Charm’s products serve the dairy, feed and grain, food and beverage, water, healthcare, environmental, and industrial markets in more than 100 countries around the globe.
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Excerpt from article: “Hardware-Software Co-Design Reappears”
It was hoped that co-design would bring hardware and software teams closer together. “It required restructuring a complete industry,” says Roland Jancke, head of design methodology at Fraunhofer IIS/EAS. “It would have meant diminishing the borders between hardware and software design groups, and making it a rule, rather than an exception, that an executable architectural model exists for hardware and software designers to work with instead of numerous pages of written specifications.”
There is widespread agreement on that point. “The number of changes that a project team would need to make to adopt a co-design methodology was immense,” says Frank Schirrmeister, senior group director for product management and marketing at Cadence. “When you consider how conservative most project teams are, the likeliness of a new methodology being adopted is inversely proportional to the number of changes it requires.”
And until recently, that wasn’t as critical from a business standpoint. But even with rising complexity, it’s still not clear whether that will be enough to upend the existing way of doing things. “Companies have been able to get away with over-engineering the hardware and independently developing the software and still producing economically viable products, especially when their competition have been doing the same thing,” says Russ Klein, HLS platform program director at Siemens EDA. “There are a lot of benefits to designing the hardware and software in concert, but the existing methodologies are deeply ingrained in the cultures of hardware and software developers, and the companies where they work. Overcoming that inertia will be difficult.”
Read the entire article on SemiEngineering originally published on July 25th, 2019.
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Speech technologies have met with an enormous success and have become a central element of our society. With the ubiquity of mobile devices, technically enabled speech communication at any time and from any place has become a commodity.
Advanced applications, such as untethered teleconferencing systems, smart rooms, telepresence or audio-visual systems for ambient assisted living or for surveillance and monitoring, are gaining importance. But their performance still often falls short of user expectations: They require a significant amount of user cooperation and attention, are tailored to specific use cases, depend on close-talking microphones, and cannot tolerate highly variable acoustic environments. Furthermore, systems that incorporate a classification and recognition component rely on an expert a priori definition of the events to be recognized, and on the availability of labeled and application-specific training data. These requirements render such systems expensive and inflexible, and their performance is still limited.
On the other hand, there is the inexpensiveness and proliferation of acoustic sensors and the ubiquity of wireless communications, which allow a cost-effective realization of the infrastructure for the aforementioned applications, based on wireless acoustic sensor networks (ASNs). Traditional microphone arrays sample a sound field only locally, often at a relatively large distance from the target source(s), resulting in poor signal quality. ASNs use many more microphones to cover an area of interest, making it likely that at least one microphone is close to every relevant sound source, capturing a signal with improved quality and saliency. But to leverage the enormous potential of ASNs for spatio-temporal signal processing and classification significant challenges have to be overcome. They are related to the loose coupling of the sensors, the spatial extent of the network, the natural acoustic environment it is deployed in, and the increased signal enhancement and analysis demands of novel applications.
This Research Unit (RU) represents a coordinated effort to transgress the boundaries of existing speech and audio technology to enable flexible, hardware-, environment-, and usage-adaptive, high-quality speech communication and acoustic scene classification over acoustic sensor networks. We categorize the corresponding applications as small-space applications (SSA) and large-space applications (LSA) according to the geometric extent of the space covered by the sensor network. The RU will address the specific challenges of these application categories as identified in the sequel.
Small-space applications (SSA) will typically rely on a few acoustic sensor nodes distributed in a single or in multiple rooms. Key applications include
- Ambient assisted living (AAL) and smart homes: Current technical solutions for AAL hardly ever consider acoustic sensors, owing to insufficient signal quality, other technical limitations, and privacy concerns. If solved, an advanced AAL system using audio will bring about many benefits: It will enhance the user's voice over arbitrary nonstationary distortions, glean context information by observing the acoustic scene, and will be able to detect abnormal and possibly hazardous events by their acoustic signature. It will hence become an important technology for an aging society to support a prolonged self-determined life at home.
- Personal communication scenarios with a natural look & feel: This includes teleconferencing without headsets and the use of multiple sound capturing devices. While today's solutions rely on pre-installed audio equipment, a possible future solution would be to let the participants' smartphones spontaneously form a multichannel sound capturing and speech enhancement system.
Large-space applications (LSA) employ acoustic sensor networks that cover an extended geographical area. Example applications include
- Surveillance of public or private spaces: While traditional audio-visual systems conduct event detection based on energy thresholding and classify signals into one of a few pre-trained classes, an advanced system will build models of the typical sounds of the environment using unsupervised and semi-supervised learning techniques, thus being more adaptive to the task at hand and requiring less costly labeled training data.
- Environmental and habitat monitoring: An acoustic sensor network can serve a multiplicity of purposes from monitoring adherence to noise control regulations to monitoring endangered animal species in a wildlife refuge. By using appropriate signal representations and local processing at the sensor nodes the amount of data the network must transmit and store will be greatly reduced.
This RU is dedicated to address the key scientific challenges which are common to these relevant applications.
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Leadership TipsSeptember 27, 2019
Creating Your Yellow Brick Road
What comes to mind when someone mentions the “Yellow Brick Road”? Do you think of the path that Dorothy followed to the Emerald City in the Wizard of Oz? Or maybe you think of the 1973 album by Elton John titled Goodbye Yellow Brick Road (yes, I’m dating myself)?
Over the years, the term Yellow Brick Road has come to mean a path to something good or worthwhile. In the book The Wizard of Oz by L. Frank Baum it symbolized the dream of many immigrants coming to this country at the turn of the 20th century that the roads were paved with gold in America and there was a better way of life and more opportunities.
What if we looked at our careers as travelling along a Yellow Brick Road? Ever-seeking the wonders of the Emerald City.
Our careers are journeys full twists and turns, hills and valleys and lots interesting people we meet along the way. Our careers will travel a long distance during our lifetime. We’ll come to many forks in the road and have to make decisions on which way to go. We may at times have to double back because of significant obstacles. And at times we may have people that guide us and that travel with us.
Sometimes the path may not be as clear as other times. We may make the wrong decision on which way to go. The good thing about a long journey is there is plenty of time and opportunities to adjust our direction and get back on that yellow brick road.
How far are you on the trip? Half-way? Just starting? Toward the end? Know where you are, recognize the good decisions you have made with respect to your career and maybe acknowledge any that weren’t quite as good. Now where do you want to go? What skills do you want to enhance or develop to make that road wider and have fewer peaks and valleys?
Write these things down.
Studies have shown we are much more likely to accomplish the things we write down. Recording them as goals is an excellent way to write them down. Share them with the people that can help you achieve them on your journey. Make a partner or two in your development. Identify people you can touch base with and check in on your progress.
Be realistic in your plans. Take on enough but not so much that you set yourself up for failure.
Write your plans down and put them in a place that you can refer to from time to time. Occasionally take them out and review them. Put a reminder on your calendar once a quarter to review your plans. Edit them and celebrate your progress. Add to them as needed. Make it a living document. Don’t throw it away because you accomplished the goals, cross them off but keep them on the list to show all that you have done. It’s important to look back and appreciate your own efforts. It’s like building your own yellow brick road.
Write things down. It’s a simple act, but an important one. Let’s all start the new year out by writing down some things we’d like to accomplish related to our leadership development and commit to ourselves we will review these things on a regular basis.
There is an old saying that “today is the first day of the rest of your life”. It’s true for your career. Today is the first day of the next stage in your development. Make 2019 the year you took significant action for yourself, and worked hard to avoid any flying monkeys.
The 2022 Atlantic hurricane season officially began on June 1, with the National Oceanic and Atmospheric Administration's (NOAA) Climate Prediction Center, a division of the National Weather Service,…
Late last year, Safeguard Properties began contracting with the Military Warriors Support Foundation (MWSF), a non-profit organization that provides a variety of programs for our nation’s combat…
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Eosinophils are a type of white blood cell. The immune system uses eosinophils and other white blood cells — or leukocytes — to ward off bacteria, viruses, parasites, and other possible causes of infection.
Eosinophils are a vital part of the immune system. They help fend off unwanted substances, known as pathogens. This process involves inflammation. Inflammation is a necessary part of the immune response, but it can sometimes be problematic.
For example, in the case of food allergies, the body mistakenly perceives certain ingredients as dangerous. As the immune system launches an attack, the numbers of eosinophils rise, and unhelpful inflammation can result, leading to swelling and other allergy symptoms.
Eosinophilia is when eosinophilia levels are high. They can
Here, learn about eosinophils, what they do, and what can happen if levels are too high or too low.
The body makes eosinophils in the bone marrow. From there, they travel to tissues throughout the body. They can be present in all body tissues, but the
They stay for
Structure of eosinophils
Eosinophils have several key features:
- a membrane that surrounds the cell
- cytoplasm, a liquid inside the cells that surrounds the granules
- around 200 microscopic granules that release substances such as cytotoxins, which kill unwanted cells
- a nucleus with 2 lobes
The nucleus and secretion granules help doctors tell eosinophils apart from other white blood cell types.
When the immune system detects an unwanted substance in a part of the body, such as bacteria, eosinophils will react to defeat them.
The role of eosinophils
- fending off bacteria and parasites
- killing unwanted cells
- participating in allergic reactions
- playing a part in inflammatory responses
An eosinophil count measures the number of eosinophils in the blood.
Doctors can check as part of a complete blood count (CBC) or as a separate white blood count (WBC) test. A CBC will measure the various cells in the blood, including red blood cells and platelets.
According to the Cincinnati Center for Eosinophilic Disorders, the expected range for eosinophils is 0–450 eosinophils per cubic millimeter (mm3) of blood.
The presence of certain health conditions
As well as testing the blood, a doctor may check for high eosinophil levels in a person’s body’s tissues, such as the nose or throat.
For example, a high concentration of eosinophils in the throat could indicate an allergic reaction to food or dust. It can indicate that eosinophils have gathered in that area to fight off a threat, real or perceived.
Eosinophils levels can rise, for example, when a person has:
- an allergic reaction
- an infectious disease
- a disease that affects the immune system
- leukemia, which affects the production of blood cells
High levels of eosinophils are called eosinophilia. This is not a disease but a sign that another health problem is present.
Doctors diagnose the following according to
- eosinopenia: very low levels of eosinophils, although there is
no specific range
- mild eosinophilia: 500–1,500 mm3
- moderate eosinophilia: 150–5,000 mm3
- hypereosinophilic syndrome: eosinophil counts are 1,500 mm3 or above on two occasions at least 1 month apart, or body tissues show high levels of eosinophils
A person can be healthy with zero eosinophils, so doctors do not usually consider eosinopenia a matter of concern.
However, some research suggests that eosinophil levels below
In people with Cushing’s syndrome, the body produces too much cortisol.
Having too many eosinophils can indicate several conditions.
A high level of eosinophils in the blood or body tissues is known as eosinophilia.
- parasitic, bacterial, fungal, or viral infections
- myeloid leukemia
- Hodgkin lymphoma
- mastocystitis, when too many mast cells collect in the skin, bone marrow, liver, and other organs
- cancerous tumors
- eosinophilic granuloma, a benign tumor on the bone
- rhinitis and other upper respiratory diseases
- asthma and eosinophilic asthma
- other lower respiratory diseases
- immune-mediated diseases, such as systemic sclerosis and primary biliary cirrhosis
- atopic dermatitis, an autoimmune disease
- chronic spontaneous urticaria, where wheals, angioedema, or both develop on the skin
- sensitivity to certain drugs, such as antibiotics
- eosinophilic esophagitis, which affects the gullet
- eosinophilic gastroenteritis and colitis
- eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss Syndrome, which combines features of asthma with inflammation of small blood vessels and other tissue damage
What happens in eosinophilic diseases?
In some immune-mediated diseases, such as eosinophilic esophagitis, the eosinophils cause symptoms.
To ward off a perceived threat, such as a food or pollen allergy, a large number of eosinophils collect in the esophagus.
This causes inflammation, resulting in swelling, reflux, and difficulty swallowing.
Here are some answers to questions people often ask about eosinophils.
What causes eosinophil levels to rise?
High eosinophil levels can indicate that the body is responding to an infection or allergen. Specifically, it can be a sign of asthma, an allergic reaction, leukemia, and various types of infection.
What are eosinophils, and what do they do?
Eosinophils are a type of white blood cell. They play a key role in the immune system. They act to defeat pathogens, such as bacteria, viruses, fungi, and parasites. They also react to perceived threats, for example, during an allergic reaction. While essential for defending the body, their activity can cause inflammation. This can sometimes lead to further issues.
What is an eosinophil count?
A blood test will show a person’s eosinophil count. A low count is not usually a cause for concern, but a count of
Eosinophils are a type of white blood cell. They are essential in the body’s immune response, as they contain proteins and other substances that can kill, destroy, or deactivate bacteria and other pathogens.
A low eosinophil count is not usually a cause for concern, but a high count may be a sign of a health condition, such as asthma, an infection, leukemia, or an autoimmune disease.
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Top 8 attractions you must visit in Nagapattinam
Contents in This Page
It is a costal line district rich in religious heritage and communal harmony.
Attractions in Nagapattinam
This is a world-famous Mariyan shrine located in the small town of Velankanni. The origin of this church can be traced back to the 16th century and there is so much miracle histories to say.
Sri Abhirami Amirthakadeswarar Temple is a Hindu temple dedicated to Shiva in his manifestation as "Destroyer of Death" and his wife Parvati as Abhirami. It is located in Thirukkadaiyur (Thirukadavur), 21 km East of Mayiladuthurai, Tamil Nadu in India. This temple is associated with the legend of Shiva saving his young devotee, Markendeya from death, and the tale of a saint, Abirami Pattar a devotee of the presiding goddess.
Tharangambadi is a town in the Nagapattinam district of the Indian state of Tamil Nadu on the Coromandel Coast. It lies 15 kilometres north of Karaikal, near the mouth of a distributary of the Kaveri River. Tranquebar was established in 1620 as the first Danish trading post in India. King Christian IV had sent his envoy Ove Gjedde who established contact with Raghunatha Nayak of Tanjore.
Vellankani Beach is one of the most pious and scenic beaches on the Eastern coast of the Indian subcontinent. It is the perfect buzz-filled holiday spot with the bustling crowds and swaying palm trees. The beach is one of the most popular destinations in the region.
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Hanoi's artisans produce stunningly decorative work including lacquerware, woodblock prints, silk paintings, embroidery and Vietnamese calligraphy. And while Vietnam's lacquer paintings may be more famous to Western travellers, the country also has a rich tradition of painting on canvas that combines European and Asian influences. After making the rounds of Hanoi's galleries, you may find yourself saturated with bicycles, monks and conical hats, so make sure to look around for something unique before you buy.
When China ruled Vietnam, Vietnamese artisans applied freshly learned Chinese techniques to creating art and ceramics in conjunction with native methods. French influence in art creation took hold by the 19th century and had tremendous weight in the birth of modern Vietnamese art. Modern Vietnamese artists began using French techniques with native Vietnamese mediums including silk and lacquer; thus, a unique blend of eastern and western artistry developed and flourished. You can buy Vietnamese traditional art at many galleries and shops throughout Hanoi.
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Last Thursday, the Federal Circuit ruled on a challenge brought by Sandwich Isles Communications Inc. (SIC) against the federal government over its request that SIC pay back tens of millions of dollars in subsidies received from aid pools. The court found, as the U.S. Court of Federal Claims previously had, that the tribunal lacked subject matter jurisdiction over the case.
The opinion explained that SIC was formed in the mid-1990s to provide telecommunications services to native Hawaiians. In 1997, SIC received a federal designation to do so and served rural communities in Hawaii by leasing capacity on an existing undersea cable. For certain leasing expenses, SIC sought and received millions of dollars in subsidies from the National Exchange Carrier Association (NECA) pool, a fund intended to support providers in high-cost areas.
Later, SIC entered into an exclusive, 20-year lease of a newly constructed cable owned by Paniolo LLC, a different corporate vehicle of SIC’s parent company. Though SIC’s subscriber base was relatively small, the Paniolo cable it leased was both expensive and “‘massive, with the capacity to provide broadband service to the entire state of Hawaii.’” The variable lease reportedly began at $15 million per year and rose to $24 million annually by 2018.
In addition, as a service provider in a high-cost area, SIC received Universal Service Fund (USF) assistance on a per-line basis. In 2011, the Federal Communications Commission (FCC) reforms substantially cut the amount of funding SIC received from the USF and eventually suspended those payments.
According to the opinion, after SIC’s founder was convicted of tax fraud in July 2015, SIC itself was the subject of an investigation. In late 2016, the FCC issued an order finding that SIC improperly received “excessive” payments from the federal high-cost support mechanisms totaling about $27.27 million between 2002 and 2015. SIC challenged the decision as an improper taking by the federal government under the Tucker Act and sought $200 million in damages.
In its analysis, the Federal Circuit panel adjudged whether the Communications Act of 1934 withdraws Tucker Act jurisdiction over takings claims, finding that it does. The court reasoned that because SIC challenged FCC actions and orders governed by the judicial review provision of the Communications Act, the claims court’s Tucker Act jurisdiction was displaced entirely.
The panel noted the proper procedure under the Communication Act’s “comprehensive statutory scheme.” The opinion stated that SIC could have raised a constitutional takings claim to the FCC, and if the FCC denied the waiver, SIC could appeal that decision to the full commission and then to a federal appellate court.
SIC is represented by Kobayashi Sugita & Goda LLP and the federal government by the United States Department of Justice.
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Artificial intelligence (AI) is the general study of making intelligent machines. Machine learning (ML) is a subtopic of AI that focuses on the development of computer programs that can teach themselves and act/adapt without the need for explicit programming when encountering new information or examples.
Research in this area explores the construction and study of algorithms that build models and make data-driven predictions or decisions. It is an impactful rapidly evolving sub-field of computer science that nearly all CSE faculty incorporate into their research.
Work in AI and ML at CSE involves foundational research in deep learning, probabilistic models and reasoning, large-scale machine learning, reinforcement learning, data-driven decision making and AI/ML in science and engineering. There are significant efforts aimed at a wide range of applications, including traditional areas such as recognizing natural language, networks, speech and images; to more cutting-edge novel ones connecting to other domains such as forecasting pandemics like COVID-19; diagnosing and treating complex diseases like asthma and cancer; detecting fraud and online adversarial behavior; designing new materials; AI for social good; incentive design for solving social dilemmas; and predicting the responses of social, natural and engineered systems.
ML spans many broad research areas and groups at Georgia Tech. CSE faculty have active collaborations with several groups on campus, including researchers from the schools of Computer Science, Interactive Computing, Industrial and Systems Engineering, Mathematics, and Electrical and Computer Engineering.
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Other Production Options
This chapter provides an overview of other options related to productions.
The User Portal (formally called the InterSystems User Portal) is intended for direct use by end users, in contrast to such back end tools as Studio and the Management Portal. The following shows an example:
The User Portal is designed to enable end users to do the following tasks:
View and dashboards, which can include production business metrics, introduced later in this chapter.
View and manage workflow tasks, introduced in the next section.
Send messages to other users of the User Portal, as seen in the upper left corner of the previous figure.
For details, see Using Dashboards and the User Portal.
InterSystems IRIS® provides support for workflow within productions. Workflow makes it possible to incorporate human interaction into automated business processes. Uses of workflow within the enterprise might include order entry, order fulfillment, contract approval, or help desk activities.
A production achieves workflow using a business process and set of business operations. A business process receives a request, organizes the tasks required to fulfill that request, and then calls upon business operations to perform these tasks.
Each of these business operations assigns the task to a workflow role, which places the task into the workflow inbox of each user who belongs to that role. To access this inbox, users work with the User Portal, introduced in the previous topic.
When a user marks as a task as complete, the workflow engine continues with the next processing step.
For details, see Defining Workflows.
Business Activity Monitoring
InterSystems IRIS includes all the elements required to include business activity monitoring (BAM) as part of an enterprise integration project.
First, it provides business metrics, which are specialized business service classes that calculate specific values at a configurable time interval. These calculations can take a variety of forms, involving calls to business operations, federated databases, the InterSystems IRIS database, or any arbitrary source code contained within the business metric class. See “Defining Business Metrics” in Developing Productions.
Second, it provides dashboards, which are web pages that provide a real-time, graphical display of metric values. Each dashboard presents one or more meters, and these display business metrics. InterSystems IRIS provides a complete set of built-in meters that includes speedometers, light bars, traffic lights, and others.
The following shows an example dashboard that displays business metrics:
An alert sends notifications to applicable users while a production is running, in the event that an alert event occurs. The intention is to alert a system administrator or service technician to the presence of a problem. Alerts may be delivered via email, text pager, or another mechanism. For details, see “Programming in InterSystems IRIS” in Developing Productions.
Publish and Subscribe Message Delivery
Productions also support publish and subscribe message routing. This technique routes a message to one or more subscribers based on the fact that those subscribers have previously registered to be notified about messages on a specific topic. For details, see Managing Productions.
The Enterprise Message Bank is an optional remote archiving facility where you can collect messages, Event Log items, and search table entries from multiple client productions. It consists of the following components:
The Message Bank server, which is a simple production consisting exclusively of a Message Bank service that receives submissions from any number of client productions.
A client operation (the Message Bank operation) that you add to a production and configure with the address of a Message Bank server.
To get started, see “Defining an Enterprise Message Bank” in Developing Productions.
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21 Jun 2007
Bossa Nova Technologies, US, is an expert in non-destructive testing equipment. Nadya Anscombe talks to its marketing and sales director Philippe Clemenceau to find out how the steel and cosmetic industries are making the most of the company's technology.
At first glance, the mechanical properties of steel and the glossiness of a lipstick do not have much in common. But measuring these characteristics is the main business of US-based Bossa Nova Technologies.
The company's SAMBA vision system, for example, is used by the cosmetics industry to measure the visual appearance of hair, lipstick and skin. This patented polarization imaging technique acquires colour and gloss images strongly related to visual assessment. "It basically quantifies what the human eye sees," Philippe Clemenceau, Bossa Nova's director for marketing and sales told OLE. "It quantifies the visual appearance of planar and complex 3D surfaces using a polarization analysis of the light scattered by the sample."
He claims that it is the first colour-imaging gloss meter and that Bossa Nova is benefiting from the huge growth in the cosmetics industry. "SAMBA sales make up about half of our business and it is the fastest-growing sector for us," said Clemenceau.
SAMBA is used to substantiate claims – such as "using this shampoo will make your hair glossier" – and also by chemists during formulation of new products. "The use of optical techniques in the cosmetics industry is growing," explained Clemenceau. "Every cosmetics conference I attend has a session on optical techniques."
Seeing the gloss
Conventional gloss meters measure gloss from a flat surface and collect light reflected in an arbitrary direction using a detector. Like conventional meters, SAMBA sends light to an object. The difference is that SAMBA images the reflected light.
"This makes the system much more powerful than a simple gloss meter because the object can have different shapes," explained Clemenceau. "Acquiring the reflected light image is equivalent to knowing how the object reflects light at many angles at the same time. The measurement is also close to how a person perceives an object and allows us to output data correlated to human visual perception."
With a conventional gloss meter, lipstick is applied to a flat card and the meter takes a measurement at various inclinations. With SAMBA, the lipstick is applied directly to the lips, and SAMBA takes images of reflected light. The results show many areas of strong reflections on the lips and image analysis can work out the distribution of gloss on the lips and how that gloss fades spatially. "SAMBA is used by many well-known cosmetic manufacturers such as L'Oreal, for formulation or claim substantiation," added Clemenceau.
But the cosmetics industry is not the only potential user of this technology. It could be used anywhere where gloss and texture is important, such as in the automotive and textile industries.
SAMBA is based on active polarization imaging and can be used to look at specular (mirror-like) reflection; surface scattering and volume scattering. While using polarization imaging is not new, the bit that makes SAMBA unique is the fact that it can switch from one polarization to another at video rate. "This means that the system can be used to take a polarization video – it is fast and responds quickly to the user," said Clemenceau. The fact that the system can take polarization videos means that it has other uses outside of the cosmetics industry, such as detecting bodies of water.
Switching to ultrasonics
The idea of switching quickly between polarization states is a simple yet technically challenging idea. Another part of the business – laser ultrasound – has also been built on a relatively simple, but equally challenging idea. Conventional laser ultrasound systems use a simple interferometer architecture to detect ultrasound waves from a surface that has been hit by laser light. While these systems are very sensitive, they are affected by surface roughness and vibrations from a factory environment.
"We realized that we needed several interferometers working in parallel," explained Clemenceau. "Our system is the equivalent of up to 100 interferometers. Summing the signal of each individual system improves the sensitivity of the overall interferometer and compensates for the roughness of the material while adapting to the object 3D motion."
The company's QUARTET system is so sensitive that it can pick up 1 nm displacements under factory conditions. To generate the ultrasound, a 10 ns pulse from a YAG laser is fired at the material causing it to heat up, expand and release an ultrasonic wave. The ultrasound wave propagates through the material and if it meets a crack for example, it reflects. When the pulse comes back to the original generation site, the surface vibrates. This tiny displacement is on the order of 1 nm.
QUARTET can visualize the propagation of an ultrasound wave through a material and make a movie of this propagation. "This is another reason why our system is unique," said Clemenceau. "Thanks to its ability to record images of wave propagation and the sensitivity of our receivers (up to 1 GHz), material research laboratories can perform high-frequency tests with an affordable, user-friendly compact laser system."
The Aerospace Engineering Laboratory of Georgia Tech, Atlanta, US, recently acquired a laser-scanning system to record the 2D propagation of ultrasonic waves on various composite parts up to 20 MHz. Thanks to this new tool, scientists will improve their understanding of the mechanical properties of new materials and will be able to detect smaller and smaller defects in them.
One of the main users of laser ultrasound for remote sensing is the steel industry. Non-contact ultrasonic inspection can be performed on moving hot steel (1000 °C) with an expensive laser ultrasonic system using high-power lasers. However, Clemenceau claims that by using his company's receiver, it is possible to significantly decrease the amount of laser power needed for the inspection, and as a result significantly decrease the overall system cost and complexity.
The steel industry uses ultrasound for a variety of tests. Because ultrasound is a mechanical wave, it can be used to measure mechanical properties of material. These include thickness, porosity, stiffness, elasticity and the detection of defects. In the steel industry, the advantage of laser ultrasound is the non-contact nature of the test and this means that hot metal can be tested without the need to halt production.
This also has advantages for other applications. "One of our customers, an automobile manufacturer, currently cuts some of its manufactured automobile parts in order to inspect their core visually and evaluate how efficient the steel preparation process is," explained Clemenceau. "After a few tests on some parts, we proved that it was possible to look at the integrity of the material non-destructively and without contact using a low-cost laser ultrasonic system based on our receiver."
The company's system is now at a validation stage at the customer's facility and the goal is to perform inspection without stopping the manufacturing line.
Bossa Nova has also recently completed a research programme funded by the National Science Foundation to improve the sensitivity of its receiver.
• This article originally appeared in the June 2007 issue of Optics & Laser Europe magazine.Optics & Laser Europe magazine – subscribe here
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Gingival Graft Pleasant Grove, UT
Also known as a soft tissue graft.
One of the unfortunate side effects of periodontal disease is the loss of gum tissue. When teeth and gums are healthy, a thick layer of keratinized (hardened) gum tissue surrounds each tooth. Gums should not bleed or feel sensitive when brushing flossing, or when experiencing minor “pokes and prodding.” However, when gum disease does occur, this tissue may recede, pulling back from teeth in a way that exposes teeth root, leaving them more prone to decay. Other factors may contribute to gum recession as well, such as advanced age, improper oral hygiene, and smoking or use of other tobacco products. For those patients who have experienced a significant loss of gum tissue, we may recommend a gingival graft. (Also known as a soft tissue graft.)
What does it involve?
With a gingival graft, we take a small portion of tissue to cover the exposed tooth and treat gum recession. The tissue comes from the soft pallet of your own mouth or occasionally sourced from a doner. Building up the gums in this way can help prevent future gum recession and provide a better foundation for tooth restorations.
If you experience symptoms of gum recession that includes exposed roots and/or sensitive teeth, then please call us at (801) 369-1713. We can provide a periodontal assessment to determine what treatment is right for you and if you might be a candidate for a gingival graft.
Benefits of a gingival graft include:
- Reverse the effects of gum recession, protecting the tooth.
- Decrease tooth sensitivity, particularly when roots are exposed.
- Increase stability for dental restorations.
- Restores a healthy, aesthetic appearance to you smile.
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Improving people’s long-term wellness through behavioural economics
User experience needs to be intuitive and seamless for any digital platform. For such a large, sophisticated wellness platform built by Vitality, this is indoctrinated in the company’s culture. Their core goal is to grow and maintain healthy living across society by rewarding people – the first of its kind for a health insurance business. There needs to be a win-win offering for all stakeholders to sustain this goal, which is why they believe in the idea of ‘shared value’.
Partnering with leading companies like Apple and Amazon, Vitality continues to develop their membership programs – and challenge their own propositions as they grow.
Join Hanno and Dave as they uncover how a large organisation stays innovative, invests in the design process, and how they build their programs based on behavioural economics.
The history of Vitality's wellness programs
Lessons learnt from behavioural analysis
How to apply behavioural economics to all businesses, beyond health and wellness
R&D at Vitality
Health and wellness trends to expect over the next ten years
How to set environments at work that drive innovation
The benefits to Vitality’s approach to design
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In a dark future universe, where human technology has not significantly halted human violence, scientists roam a distant star system selling an opium-like drug, and plans are made to fuse human DNA with a lifeform called the Grub in hopes of finally erasing humankind’s most violent tendencies.
Severna Park, author of the related SF novels Speaking Dreams and Hand of Prophecy, turns to a new universe in The Annunciate. ThreeSys is a three-star system, and each star has 11 human-settled worlds. The humans are separated not only by vast distances but also by technology, divided into Jackless, Jacked, and Meshed. The Jackless have no access to the virtual reality of the Jacked. And neither caste has access to the nanotech-sculpted dimension that the Meshed can enter to control and manipulate them.
When Jackless and Jacked rise against their overlords, three Meshed survive and struggle to retain their mastery with Staze, a potent, immediately addictive drug that traps users in an overwhelming dream. But the dream may be the entrance to another world–one inhabited by a mysterious and powerful being that wishes to enter our universe. Is it the Unknown Child, the long-prophesied savior of ThreeSys? Or is it an alien predator that will destroy humanity?
The Annunciate is an interesting, ambitious consideration of love and need, power and responsibility, and the complexities of human bonds. –Cynthia Ward
From Library Journal
In the far future, humanity has spread throughout the galaxy and fragmented into three distinct factionsAthe Meshed, the Jacked, and the JacklessAaccording to their ability to access virtual technology. Hunted to near-extinction by the other two factions, the Meshed maintain a precarious existence until a strange, alien being encounters a trio of Meshed fugitives and announces itself as their salvation. The author of Speaking Dreams depicts a grim future where fear of “the other” takes precedence over trust and good faith. Marred only by the lack of appealing characters, this novel of ideas belongs in large sf collections.
Copyright 1999 Reed Business Information, Inc.
From Kirkus Reviews
Far-future virtual-reality/alien-contact yarn from the author of Hand of Prophesy (1998). In Park’s 3-sun, 33-planet ThreeSys, those “Meshed” (connected through internal and external nanomachine “propagats”) have access to an augmented sensory/information Net. The Jacked have merely a standard plug-in computer/machine interface. The Jackless have nothing. To restrain ThreeSys’s endemic violence and warfare, the Meshed introduced an addictive, pacifying drug called Staze. The non-Meshed retaliated with computer viruses that wiped out all the Meshed save Eve, Annmarie, and Corey. Only these three know how to make Staze, but will they choose to bring a drug-induced peace, or seize control of everything? What remains of the Mesh is failing, and only on planet Paradise, the first planet to be colonized, subsequently blasted by war, do old-type, virus-immune propagats survive. Eve, the junior partner, constantly betrayed by Corey or manipulated by Annmarie, wants only her Jacked, Staze-addicted lover, Naverdi. But the Paradise propagats soon take over their ship’s systems and combine with worms and moss on the planet to produce a “succubus,” an ignorant but powerful construct. The succubus grabs Naverdi and impregnates her with the Unknown Child, meanwhile linking Meshed and Jacked with all ThreeSys’s Staze addicts through their dreams. Will this, as the addicts believe, deliver enlightened peace? Or, as Eve suspects, is the succubus a voracious alien predator? A passionate, ferocious…swirl of sex, treachery, religion, drugs, technology, and transcendence. — Copyright ©1999, Kirkus Associates, LP. All rights reserved.
“The Annunciate has nanotechnology and spaceships, but at its heart is Severna Park’s delicate calculus of human need-the need for information, for a fix, for a place to live, for a lover and for a mother–the need for hope.” — Maureen F. McHugh, author of Mission Child
“A spellbinding brew of love, fear, nanotechnology, virtual reality, sex, drugs, and a profound meditation on the nature and possibilities of human interaction.” — S.M. Stirling
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Curriculum By Grade
6th-8th Grade: Middle school students begin with teacher led thematic units to introduce project skills and focus on collaborative learning. The curriculum will be built around traditional Ojibwe lifestyles traveling through the natural seasons for sustenance and will be structured into thematic units intertwined with traditional ecological knowledge (TEK) and cultural teachings.
9th-10th Grade: Students have a mix of student and teacher led project-based learning to develop time management skills, and meet core credit requirements.
11th-12th Grade: Students are responsible for managing their own independent learning plan, with focus on high level research projects, becoming active members of their community, and project mentoring younger students.
Example of a Thematic Unit:
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[R-SIG-Finance] How to test pairs trading strategy
veepsirtt at gmail.com
Sat Jun 11 06:50:33 CEST 2011
Please visit the link
in page 18
they say how the entry and exit signals are generated in PAIRTRADEFINDER
Using the default signal settings, trading signals are generated at 2.70
standard deviations from the 100 day mean average of the ratio, an exit
signal is generated when the pair goes past 1.00 standard deviations;
i.e.….its goes closer than 1 standard deviation to the mean. The current
reading on each pair is shown in the +/- column in the home page.
To analyse each pair further, you can select a pair in the home page then
click on the pair charts button.
How could this be incorporated in the quantstrat pair trader demo ?.
View this message in context: http://r.789695.n4.nabble.com/How-to-test-pairs-trading-strategy-tp3558776p3589963.html
Sent from the Rmetrics mailing list archive at Nabble.com.
More information about the R-SIG-Finance
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“The culture of a company is the behaviour of its leaders. Leaders get the behaviour they exhibit and tolerate. You change the culture of a company by changing the behaviour of its leaders. You measure the change in culture by measuring the change in the personal behaviour of its leaders and the performance of the business”
“Execution: The Discipline of Getting Things Done” by Larry Bossidy and Ram Charan
There has been a paradigm shift when it comes to performance feedback. Many organizations and clients I have worked with have adopted a performance management cycle that veers away from the traditional annual review. Instead, organizations are choosing to adopt processes allowing for continual feedback. Considering the data that shows that 43% of highly engaged employees receive feedback at least once a week as opposed to 18% of low engagement employees (Source), this has been a welcome change.
However, upward feedback is not so readily embraced by leaders. When working on revamping performance management processes for my clients and introducing the concept of upward feedback, some of the responses often sound like this:
- “I don’t feel comfortable having people anonymously tell me what I do and don’t do”
- “I’m scared to hear what they have to say … why open up a can of worms?”
- “I already know what I’m doing well on and not doing well on, so why do I need to hear it from others?”
- “How can we ensure that our people will be objective and constructive in their feedback?”
If we are in a position to give feedback, I believe we must also be vulnerable enough to welcome, solicit and accept feedback. As Brené Brown has said, “If you’re not in the arena also getting your ass kicked, I’m not interested in your feedback.”
Upward feedback does not have to be complicated nor labour intensive. Here are some critical considerations before launching your upward feedback process:
Use open-ended questions
There is so much more value in comments as opposed to rating scales. Especially when assessing leadership performance and capabilities, empower your people to provide details and specific examples on their feedback. Remember, the purpose of upward feedback is to leverage the intel to help improve and modify specific behaviours.
I often include three questions in the upward feedback:
- What should this leader continue doing?
- What should this leader stop doing?
- What should this leader start doing?
Assess Core Values
Core values need to be more than just words on a wall. They need to be woven into the fabric of our everyday actions and behaviours as leaders. Living and breathing the core values is our role as leaders.
Use the upward feedback as an opportunity to ask team members if these core values are being exhibited and incorporated into the daily habits of your leaders. We know that culture is driven from the top, and therefore assessing whether or not leaders are living these core values day in and day out is critical.
If you want honest and robust feedback, consider making your upward feedback confidential. Your team members need to feel safe to provide candor in their responses. The real purpose of upward feedback is to gather information and data, not to determine who said what.
I have seen a much higher completion rate when the upward feedback is guaranteed to be anonymous. In fact, comments are lengthier and more honest when feedback is anonymous. Be clear and up front that the feedback is confidential and when sharing the results with respective leaders, compile the comments in such a way where it is not verbatim. This way, it ensures that the leader cannot decipher who the feedback came from. Compile data comprehensively and cumulatively.
Upward feedback is a cornerstone and a best practice in leadership development and execution. It sheds light on the current performance of your leaders, providing clarity on what to work on to lead teams better and achieve business results. So think simple and start small – begin to show up in the arena to pursue continual learning and development.
Establishing a robust performance management process will help your business promote, improve and measure employee effectiveness and overall performance. Having a structured approach and clear roadmap of organizational goals will enhance employee performance in alignment with your company strategy and objectives. An effective performance management strategy, structure and system will help you to retain, reward and develop your greatest asset – your people.
At Upskill Consulting, we’re here to support you, your business and your people. If you are thinking about introducing or upgrading your upward feedback process, we can assist.
What can we do to help?
- Conduct preliminary assessment of your current performance management processes/systems
- Identify gaps in performance management process
- Suggest alternatives and implement tailored performance management solutions
- Promote a culture of performance feedback through training and administration of process
- Revamp or create efficient and effective performance management processes
- Develop and deliver performance management training to leadership and staff
- Propose performance management systems to align with business and HR strategy
- The Importance of Soliciting Upward Feedback as Leaders - June 30, 2022
- Workplace Discrimination, Bullying and Harassment: Employer Obligations - April 7, 2022
- Empathy: A Critical Leadership Skill - March 1, 2022
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Panela is a fresh Mexican cheese that has a mild taste and a soft creamy texture. Made from cow's milk, the cheese is an adaptation of Greek basket cheese. It has a variety of uses in the kitchen and is excellent crumbled over tacos, nopale salads, quesadillas, or huevos rancheros.
In some parts of the world, finding panela can be a challenge. If you can't find it in your store then keep reading. We've compiled a list of our favorite panela substitutes so that you can finish any recipe without the original ingredient.
What are the best panela substitutes?
To replace panela in a recipe your best options are paneer or halloumi for frying; to crumble as a topping then try ricotta, cottage cheese, or Cotija. While each option has its unique flavor and texture, they are all comparable cheeses and won’t be out of place in any dish that calls for panela.
Use for frying and slow-cooking
Paneer is an Indian cheese that has a mild, milky flavor similar to panela. It is a firm, fresh cheese that is usually unsalted and may seem bland if eaten straight from the pack. However, this is an excellent cheese for frying on a high heat or slow cooking in curries and chili beans. It can withstand the heat without losing shape.
In the United States, paneer is a common product that can usually be found in mainstream supermarkets. If you're interested in a delicious use for this cheese, be sure to check out our handy article which compares saag and palak paneer.
Use for frying and slow-cooking
Halloumi is another useful replacement for panela cheese if you need it to withstand heat without melting. When eaten raw, this product is bitter and salty thanks to the brine that it is packed in. Once cooked, the strong taste disappears, and the cheese takes on the flavors of the other ingredients in the dish. It offers a pleasant creamy mouthfeel, but is also rubberier than panela and has a texture that squeaks when you bite into it. This may be a positive feature, depending on your personal preferences.
Use for crumbling
Ricotta is a mild-tasting, fresh cheese with a creamy, somewhat grainy texture. It has a milky, slightly sweet taste and looks similar to panela. It is excellent for crumbling over soups and tacos or added to the contents of a burrito. For sweet desserts, puddings, and pies, ricotta is an excellent choice. Try to find a variety that is firm in texture if possible as this will better mimic the texture of panela.
4. Cottage cheese
Use for crumbling
Cottage cheese is a first-rate panela alternative if you’re looking for a healthier choice. It is helpful for people looking to lose weight and is high in Vitamin B, protein, selenium, and calcium.
Cottage cheese is a fresh cheese that has a soft, moist texture made up of curds that are mixed with cream or whey. Its mild, slightly sour flavor makes it ideal for sprinkling over your favorite Mexican food.
5. Queso Oaxaca
Best for stuffing or grating
Queso Oaxaca is a Mexican cow’s milk cheese. It is a white, semi-soft variety that belongs to the pasta filata family. The cheese is stretched and kneaded into a long rope, then sold in balls. Oaxaca has a mild, buttery flavor and is a little salty. Its texture isn’t as crumbly as panela, but it can still be grated onto meals like beans, soups, or tostadas.
Oaxaca melts so don’t use it as a replacement in recipes that require the cheese to hold its shape. Instead, stuff it into enchiladas, peppers, or quesadillas for a deliciously creamy, cheesy dish.
6. Queso fresco
Best for crumbling or cubing
Queso fresco, or “fresh cheese”, is a mild, fresh-tasting cheese that balances out heavy, meaty recipes deliciously. It also makes a tasty addition to lighter dishes like grilled vegetables or salads. This is a lighter cheese than most of the others on this list and won’t add the same buttery mouthfeel to meals. Although cooking will soften queso fresco, it won’t melt.
7. Farmer’s cheese
Best for crumbling
Farmer’s cheese is a type of cottage cheese that is pressed, resulting in a firmer texture with less moisture. It can be used in a similar way to panela in cooking and is ideal for sprinkling over food. Farmer’s cheese can be produced from sheep, goat, or cow’s milk so it’s flavor can vary from very mild to acidic. It is sometimes rolled in herbs or other seasonings so check the label to make sure it’s suitable for your dish.
8. Non-Aged Cotija
Use for crumbling or grating
Cotija cheese is a Mexican cheese made from cow’s milk. When mature, it is a hard, dry cheese that has a salty flavor, similar to Parmesan. Although this is an excellent cheese for use in Mexican cuisine, the immature version will more closely mimic the taste and texture of panela. It is moist and crumbly with less saltiness – great for adding rich, creaminess to food.
Best for grating or slicing
Fresh mozzarella has a subtle, milky flavor with a soft texture that is low in fat. The low-moisture product will make a great panela substitute; it is a popular variety of cheese that is easy to find in supermarkets. Grating fresh mozzarella can be a challenge so break up the cheese with your hands and sprinkle it over the dish. You can also slice it and add to salads, pizzas, or simply eat as a snack.
Summary of panela substitutes
|Paneer||Frying, slow cooking||A versatile Indian cheese|
|Halloumi||Frying, slow cooking||More rubbery texture|
|Ricotta||Crumbling||Also great for desserts|
|Cottage Cheese||Crumbling||Healthy option|
|Queso Oaxaca||Stuffing, grating||Won’t hold its shape when heated|
|Queso Fresco||Crumbling, cubing||Light and fresh tasting|
|Farmer’s Cheese||Crumbling||Firm with low moisture|
|Cotija||Crumbling, grating||Non-aged is closest to panela|
|Mozzarella||Grating, slicing||Get the fresh variety|
Fast facts about panela
- The cheese originated in Mexico, but it is unclear what year it was first made.
- The cheese is also excellent for frying as it holds its shape and softens but does not melt. Other useful options are baking or slicing and adding to sandwiches, tortas, or cemitas.
- It is hung in a basket to set so people often call it “cheese of the basket” or queso de la canasta.
- The cheese has a basket pattern on its outside which comes from the basket it is set in.
- While panela is a useful ingredient in many recipes, it is also excellent for eating on its own as a snack.
How do I reheat tamales?
Panela is a mild, soft cheese that is good for frying, crumbling, and slicing. Paneer or halloumi will work well as a substitute ingredient for fried or slow-cooked meals. There are plenty of soft cheeses to replace panela such as ricotta, cottage cheese, or queso fresco. Queso Oaxaca is a great choice in heated dishes if you want the cheese to melt, rather than hold its shape.
What recipe are you looking to make that calls for panela cheese? Please let us know in the comments below.
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You’ve probably been spending a lot more time in front of screens recently. Whether that’s because you’re now taking classes online, or because you’re scrolling through social media since you have more free time these days, there’s one thing that’s certain: we could all benefit from reducing our screen time.
Here are our top 5 tips for how to digital detox!
1. Set a timer on your phone
If you find yourself scrolling through social media posts only to look up and see that you’ve been staring at your phone for 45 minutes, you’re not alone. It’s easy to look at Instagram for too long, get caught up in TikTok videos, or even read too many news articles.
That’s why it’s a good idea to set a 10-minute timer on your phone when you pick it up — it will save you from scrolling for too long!
You can even do some environmental good by leaving your phone alone: Forest is an app that lets you grow trees by not touching your phone for a set amount of time. You can even use the virtual coins you gain in the app to plant a tree in the real world!
2. Don’t overdo your online social life
You’ve probably had lots of invitations to Zoom parties or virtual catch-ups with friends, and while it’s very important to stay connected during this time, it can become too much.
Just like in life before lockdown, you shouldn’t feel pressured into accepting every social invitation you receive. If you need an evening to yourself, that’s ok — your friends will understand.
3. Find a hobby that doesn’t involve screens
A good tip for how to digital detox is to take up a new past-time. There are plenty of hobbies that don’t involve looking at a screen: maybe you’ve always wanted to learn how to knit, or perhaps you would love to improve your art skills, take up yoga, or you like to sing. Reading books is also a great way to escape your phone and immerse yourself in a different world for a while.
4. Do those chores you’ve been putting off
Just because you’re spending more time at home doesn’t necessarily mean that you’ve been keeping on top of your chores.
You might have a pile of laundry that still needs to be put away, or maybe your drawers could benefit from some organising — instead of picking up your phone during your study breaks, how about taking 5 minutes to do some tidying? You’ll probably feel much better once you’ve done it, and it will be one thing checked off your to-do list.
5. Take a nap (and turn your phone off while you do!)
It’s important to get enough sleep so that you can study and function properly. Now that you’re at home more, why not make the most of that extra time and squeeze in a nap?
This will be especially useful if you’re taking part in digital learning, since your schedule might be a bit different depending on where you are in the world. You might need to stay up later for a live class that’s taking place in the USA or UK, so a power nap could help!
We hope these tips for how to digital detox help you, so that you can get the most out of your day, and reduce your screen-time.
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M. (2017). observed an increase in serum levels and hepatic expression of as well as pro\inflammatory cytokines in elderly subjects. Circulating levels of cell\free mitochondrial DNA were significantly higher in elderly subjects with elevated serum levels of GDF15. In the BXD mouse reference population, mice with metabolic impairments and shorter survival were found to exhibit higher hepatic expression. Mendelian randomization links reduced expression in human blood to increased body weight and inflammation. GDF15 deficiency promotes tissue inflammation by increasing the activation of resident immune cells in metabolic organs, such as in the liver and adipose tissues of 20\month\old mice. Aging also results in more severe liver injury and hepatic fat deposition in expression was higher in old mice (20\month\old) compared to young mice (8\week\old) (Physique S1b). Likewise, hepatic expression was remarkably increased in elderly subjects compared with young people (Physique ?(Physique1c).1c). We confirmed Orlistat this age\related increase in hepatic GDF15 expression in two impartial large human transcript datasets: (1) a liver microarray dataset (Innocenti et al., 2011) (Physique ?(Figure1d)1d) and (2) the RNA\Seq data of the human Genotype\Tissue Expression (GTEx) project (Consortium, 2015) (Figure ?(Figure1e).1e). In both datasets, GDF15 expression decreases in very young subjects (up to 30?years old), remains constant between 30 and 50?years of age, and then increases again after 50?years old. These non\linear age effects are significant in both the microarray dataset (limma analysis, expression is usually 65% higher in 60\ to 81\year\old subjects as compared to 20\ to 40\year\old subjects (corrected for gender and ancestry, is also highly expressed in murine livers compared to other tissues (Physique S1c). If we equate 6\months\old mice to 30\year\old humans and 14\month\old mice to 50\year\old humans (Fox, 2007), this trend can also be observed in C57BL/6?JN mice (Physique S1d) (Tabula Muris et al., 2018). The lower expression in very old mice (27?months old) might be due to survival bias as only ~50% of mice reach this age. Open in a separate window Physique 1 GDF15 correlates positively with aging\induced systemic inflammation in humans. (a) Correlation analysis of serum GDF15 levels in Orlistat human subjects. (b) Serum levels of GDF15 in young (40; n?=?14) and elderly (60; n?=?24) subjects. (c) Hepatic expression of in young (40; n?=?8) and elderly (60; n?=?8) subjects. (d,e) The effect of age on hepatic expression in (d) a microarray dataset showing patient\averaged hepatic log2\transformed intensities for 202 patients (Innocenti et al., 2011), and (e) a GTEx RNA\Seq dataset Orlistat with log2\transformed expression in transcripts per million (TPM) for 226 liver biopsies. Men are denoted as black circles, women as red triangles. The blue trend lines are obtained by fitting regression models with linear and quadratic age effects to the data. The transparent blue bands denote the 95% confidence intervals corresponding to these models. (f) Serum levels of TNF in young (40; n?=?14) and elderly (60; n?=?24) subjects. (g) Quantitation of mtDNA levels in ccf\DNA from Mouse monoclonal to CD19.COC19 reacts with CD19 (B4), a 90 kDa molecule, which is expressed on approximately 5-25% of human peripheral blood lymphocytes. CD19 antigen is present on human B lymphocytes at most sTages of maturation, from the earliest Ig gene rearrangement in pro-B cells to mature cell, as well as malignant B cells, but is lost on maturation to plasma cells. CD19 does not react with T lymphocytes, monocytes and granulocytes. CD19 is a critical signal transduction molecule that regulates B lymphocyte development, activation and differentiation. This clone is cross reactive with non-human primate plasma in study participants. (h) Serum levels of GDF15 in subjects with the 20% lowest (bottom; n?=?14; mean age, 46.4?years old) or 20% highest (top; n?=?14; mean age, 65.5?years old) plasma levels of ccf\mtDNA copy numbers. Data are expressed as mean??SEM. *expression and serum levels of GDF15 are associated with aging\related inflammation and mitochondrial damage. 2.3. Analysis of transcriptome datasets from the Genotype\Tissue Expression (GTEx) project To further investigate the relationship between and inflammatory response at the transcriptome level, we utilized GTEx RNA\Seq data from the liver, adipose tissue, and skeletal muscle to observe whether expression is associated with systemic inflammation in humans. Differential expression gene analysis (DEA) was performed by dividing the data into two groups (top 25% and bottom 25% group) based on expression levels. First, DEA was performed in the liver (Physique ?(Figure2a).2a). The Clog10(q\value) for was equal to 191.7, confirming that each group was well\differentiated by the expression of (Physique S3a). The DEA results.
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Protecting your eyes and body is especially important when handling hazardous materials. Should an accident occur despite all other safety precautions, eye/face wash stations and emergency combination showers are a necessity.
Using newly patented technology, RuptureSealTM can safely close breaches, minimize damage, help protect the environment, preserve health and safety, potentially save thousands of dollars through spill remediation, and save lives.
Explosion protection can quickly become an issue in all industries: Many hazardous substances that are handled on a daily basis harbour a corresponding hazard potential. Here you can find out what you need to know to get started with explosion protection.
Safety barrier and impact protection selection guide
With the right impact and collision protection, you can effectively secure your inventory against impact. At the same time, you'll minimise the risk of work-related accidents. We will show you how to select the appropriate impact protection or barrier system for your needs.
Find out what needs to be considered to create the optimum lighting conditions at the workplace and which legal regulations need to be taken into account in our practical FAQ on "Lighting in workplaces".
The protection of eyes and body is of particular importance when dealing with hazardous substances. Should an accident occur despite all other safety precautions, eye/face wash stations and emergency combination showers are a necessity. Additional remedial measures also need to be initiated immediately to keep possible damage to a minimum.
DENIOS offer a range emergency showers suitable for every situation and requirement. A full body decontamination shower provides fast first aid to minimize possible contamination of the body following an accident. They are extremely easy to use and can be wall or ceiling mounted or free-standing. We also offer a range of safety shower combinations, which provide the features of a full body emergency safety shower but also include an additional eye and face wash.
In the event of an incident, DENIOS also offer a variety of eye wash stations and emergency safety showers for effective and immediate first aid, all easy to install and use.
There are many safety requirements that are crucial to consider when planning and operating production processes. Safely transporting your production materials is equally as important as having correct signage in place in your facility. You need to consider all these essential onsite requirements when you plan, implement and maintain production operations throughout your company. DENIOS is a trusted expert in the field of occupational safety and facility maintenance.
Protecting Your Eyes and Body is Important When Handling Hazardous Materials.
For any business working with hazardous materials, an emergency shower should be an integral piece of onsite equipment to ensure employees are best protected and should be installed in potentially hazardous areas as it is essential that the body and/or eyes are rinsed quickly after contact with hazardous substances.
Not only in case of cauterization of the eyes (for example due to acid or alkali contact), immediate rinsing with an emergency shower is necessary to avoid lasting damage. Basically, a flushing time of 20 minutes is recommended. In order to minimize possible contamination of the body, full-body showers are also used for quick first aid after accidents.
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What Does an Administrative Assistant do?
Administrative Assistants typically work for organizations to oversee routine and advanced duties for other professionals. They work closely with Administrators and other employees to organize files, create correspondence and prepare reports or documents. Their job is to complete a range of clerical tasks including manage calendars, sorting mail, or preparing invoices. They may also be responsible for engaging in event planning and meeting setup and implementation.
Administrative Assistant job description intro paragraph
When writing an Administrative Assistant job description, start by introducing the job and company to prospective Admin Assistants. Briefly highlight the work environment, what sets your company apart and why the role is important to your company.
“Company ABC is looking for a highly organized and detail-oriented Administrative Assistant to keep our downtown office running smoothly and efficiently. This is a great opportunity to assist our employees with diverse projects and provide general administrative support.
We’re a small company of less than 100 employees, which means there’s lots of room for growth and learning opportunities. Here at Company ABC, we’re committed to creating an inclusive culture where all employees feel welcomed and valued. We’re proud to have a 5-star rating on Indeed Company Pages and an above average Work Happiness Score from our employees.”
Administrative Assistant Skills and Qualifications
In order to perform their various duties, an Administrative Assistant must exhibit many varied skills and qualifications. At the core, the Administrative Assistant is a support position, meaning that communications and decision-making are paramount. A few of the specific skills that all administrative assistants should possess include:
Decision-making: Administrative Assistants have to make independent decisions on a daily basis, addressing the best way to handle specific tasks.
Communications and collaboration: An Administrative Assistant must collaborate with other administrators and support personnel, management and clients on a regular basis.
Organizational skills: Organization and prioritization are the core elements of the Administrative Assistant’s responsibilities. You must know how to keep yourself and others organized and how to determine which tasks are the most important in a given list.
Writing: Spelling, punctuation, sentence structure and writing are essential to an Administrative Assistant, who must be proficient in a variety of styles, from creative to professional to technical to education and more.
Administrative Assistants can make a fairly good living, especially as they advance in their job. While the starting salary for a brand-new secretary-level Administrative Assistant can be as low as $7.25 an hour, on average an Administrative Assistant in the United States makes about $15.42 per hour. At the highest end of the range, executive Administrative Assistants with a great deal of education and experience can earn as much as $30.25 an hour.
Administrative Assistant Education and Training Requirements
The minimum level of education for an Administrative Assistant is a high school diploma or GED. Temporary agencies may also provide training in these areas. For those straight out of high school, courses in word processing and general office procedures are offered at vocational schools and community colleges and can be very helpful. Administrative Assistants with a bachelor’s degree are more marketable, as they are seen to have a more well-rounded education that includes writing and mathematics, which can be useful to the job.
Administrative Assistant Experience Requirements
While prior experience is not strictly required for work as an Administrative Assistant, many employers value prior work in the field. This is because many office professionals learn their major skills through on-the-job training, and a strong history of long-term work with other organizations can show reliability, responsibility and that you possess the skills you need. Starting as a secretary and working up through the ranks also shows increasing skill development and dedication.
Job Description Samples for Similar Positions
If this sample description doesn’t work or cannot be modified for your specific position, you may want to look at a few other Indeed job descriptions for related positions.
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Ten days after the self-proclaimed Islamic State’s harsh offensive emptied out a cluster of Assyrian Christian villages in northeast Syria, the extremists’ intentions toward their 220 or more Christian hostages still remained unclear.
According to the Syrian Observatory for Human Rights, an Assyrian commander said IS extremists released 29 of their Christian hostages on March 1st, citing a so-called “Sharia court decision” to set them free. But the first group of released captives to reach safety in Hassaka city on March 2nd numbered only 19.
All in their 50’s or older, the 19 former captives included 17 men and two women. All were civilians from Tel Goran village; except for one hostage believed to have been captured by IS a month earlier. Local Sunni Arab leaders reportedly helped negotiate for the release of the Tel Goran hostages. “We did not believe that we would come out alive,” one of the released Christians later told the Assyrian International News Agency (AINA). “We were in constant fear.”
On March 3rd, four more hostages, including a six-year-old girl named Mariana and her great aunt, were released and welcomed to Hassaka by crowds of relieved Assyrians. Although the militants ordered the release of Mariana’s father in the first group of captives, they demanded that he return to pay a ransom before they would set his daughter free. The other two released Assyrians were from a separate village, Tel Shamiran.
According to one of the released Tel Goran hostages who spoke by telephone with AINA, everyone in the small village was awakened, rounded up and kept under guard during the initial three hours of fighting in the early hours of February 23rd. The 17 men and four women were driven to Mt. Abdul Aziz for the first night, and then the next morning driven north another four hours into the mountains.
For the next five days, he said, “They kept pressuring us to convert to Islam. It was their constant focus. But we were not mistreated.” When the Christians refused to convert, they were told they must then pay the jizra “tax” for not becoming Muslims.
“We said we would pay the jizra, but we would not convert.” Later, their captors said they would not collect the jizra, since villagers had not fought against them. But the condition of their release, the IS fighters said, was that the Christians could not return to their village.
“They said if we returned and they captured us again, they would kill us. They would behead the men and enslave the women.”
The Associated Press, citing the Assyrian Network for Human Rights in Syria, has reported that the extremists could be positioning their captives as human shields from coalition air attacks against Shadadi town, 40 miles south of Hassaka. News reports also have cited relatives of hostages saying IS fighters answering the mobile phones of their hostages have suggested they wanted prisoner swaps with the Kurdish forces, who have captured IS fighters.
Violent clashes are continuing between IS militants and the Kurdish and Assyrian forces, who are trying to drive them from the Khabour region of Hassaka province. In one significant victory on February 27th, Kurdish fighters pushed the IS militants out of Tel Hamees, a strategic stronghold near the Syria-Iraq border which the jihadists had held for nearly a year.
“The southern bank of Khabour River is now controlled by IS,” said Rev. Emanuel Youkhana, head of the Christian Aid Program in northern Iraq. “The northern part is controlled by Assyrian and Kurdish fighters,” and the area’s 3,000 Christians have all evacuated their homes now and fled to Hassaka and Qamishli, he said.
With Turkey discouraging the flow of refugees into their nation, some 40 displaced Assyrian Christians have fled across the Lebanese border, where they began arriving on March 2nd. Lebanese Parliament member Michel Aoun spoke out strongly in support of the special one-week visas being granted to the displaced Assyrians, declaring at a press conference March 3rd, “We do not want [Christians] to take refuge in Europe or anywhere else. It is a crime to treat in that way the people who have lived in the Levant for centuries.”
Meanwhile, church leaders in Hassaka province are caught in a “sensitive situation” concerning the several hundred remaining Christian hostages, Emanuel told World Watch Monitor from Dohuk, in northern Iraq. “We are focusing on saving lives and the safe release of these people. Our bishop and church in Hassaka are doing their best.”
Source: World Watch Monitor
Father, we are overwhelmed at times as to how to pray for the nation of Syria, Christians and Muslims alike. But today, we pray for the hostages who were released; that You would provide a place to live, along with other Christians in the area. We pray for healing from the fear they must have experienced at the hands of IS forces and give thanks for their protection. And we pray for the hostages who remain in captivity; that You would protect them and cause Your peace that transcends all understanding, to rest upon them. We pray for the Christians in Syria, especially the church leaders, as they consider their response to the civil war that continues to rage through the country. Lavishly pour out Your wisdom and understanding upon them as they consider the complex political situation and the difficult decisions they must make. In the name of Jesus, through whose sacrifice the Spirit of the Living God dwells within us, Amen.
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Although it feels irrelevant to contemplate Nietzsche’s prophetic writings in the weeks after September 11th, especially sitting where the World Trade Center’s shadows used to be, it also has a reassuring effect. Partly this is because he seems so good at describing the present. As contradictory interpretations of the attack hustle for our attention, Nietzsche speaks of the modern age as a proliferation of values, ontologies, and interpretations of the world.
What’s even more reassuring is Nietzsche’s delight about the centuries ahead, whereas our anxiety over the U.S. military actions and terror at the thought of more attacks make next week look like a threat and “next year” sound as though it will always have quotation marks around it. Nietzsche can’t wait for the future. He gleefully sees morality perishing two hundred years down the line. He calls on everyone who loves the human species to help create a new kind of philosopher who knows how to think. Forget the sorry present and don’t lose heart over past disasters.
What’s curious is that Nietzsche doesn’t make any actual predictions. Just wait, he says, when things get really different they will sure be weird. He does announce that morality will perish, but since he thinks we really don’t know what morality is, that’s being handed to us as a message we can’t read. In the Genealogy of Morals, he calls the bad conscience an illness, “as pregnancy is an illness”: this both says that guilt makes you feel uncomfortable and walk funny, which makes clear enough sense, and presages a new birth of human possibilities, which means almost nothing.
Nietzsche would say he’s being as specific as he can. If he described the future more explicitly we couldn’t understand him. We have no words for prophetic communication when the future promises to be so different that the present’s words don’t capture it.
But how does that work? Have words been left out of our vocabulary? Is this like someone in the 1880s foreseeing Reese’s Pieces or Palm Pilots and not knowing how to pass the vision along?
And if it is about not having the words to describe the future, then what’s a reader supposed to do with empty hopefulness from the nineteenth century? Nietzsche didn’t know about airplanes and skyscrapers, and he wasn’t talking about that kind of thing anyway. But that’s the future that has turned out to matter, not some imaginary life that lies beyond words.
Maybe Nietzsche’s expectations seem beside the point because of the unsavory doctrines connected with his name. You might imagine him saying that the gloriously heartless morality of the masters fell to cunning slave morality and must return; and healthier human animals once lived sensually in the moment, before sliding into guilt, self-denial, neurotic monotheism—all of which it’s now time to sweep away.
Whether or not Nietzsche thinks such happy humans ever did populate the past, they are not his vision of the future. If he gets nostalgic about the carefree violence of ancient days, he also deflates his own nostalgia. The masters may have been happy and strong, but their dullness made them fragile, too. They never understood the world they lived in. The guilty conscience may lash the human animal from the inside (doubling the surface area available to be whipped), but it also gives the animal an inside it never had before and the promise of developing into something better.
Anyway, it’s misleading to call modern culture an example of slave morality as opposed to master morality, guilt as opposed to its absence, ascetic idealism as opposed to art. Nietzsche sees moderns as palimpsests who’ve been written on in different languages, at different times, for different purposes: there’s humility in them but also nobility; a bit of responsibility and a dose of guilt; religious faith and trust in science on one hand, art-loving on the other. “We modern men […] are determined…by different moralities,” is what he says in Beyond Good and Evil (all translations by Walter Kaufmann); “our actions shine alternately in different colors, they are rarely univocal”. Prehistory is “present in all ages,” not because humans don’t change but because they change by adding values and practices to the ones they already have. Even if moralities once existed in pure form they’re mixed together now; and mongrels come from thoroughbreds, not the other way around.
Beyond Good and Evil, subtitled Prelude to a Philosophy of the Future, is the book in which Nietzsche most often looks ahead toward the “exceptional human beings” he’s waiting for, reckless philosophers he calls experiments. “Many generations must have labored to prepare the origin of the philosopher,” and he considers his book part of the labor.
Given words like “generation” and “labor,” it’s not surprising to find Beyond Good and Evil circling around the topic of procreation, the business of where these new philosophers are going to come from; only procreation turns out not to mean what you think. Nietzsche helps himself to the language of birth and pregnancy but he makes it metaphorical. A genius is “one who either begets or gives birth, taking both terms in their most elevated sense,” he says—and the emphasis is his, pointing with both hands at the biological language at the same time that he denies its biological meaning. In another place, back on the subject of geniuses, Nietzsche says that there is “one which above all begets and wants to beget, and another which prefers being fertilized and giving birth.”
These are the kinds of sentences that frustrate Nietzsche’s readers, as they are full of language that keeps promising to cut through the philosophers’ intellectualism—language of sex and pregnancy, of domination, violence, exploitation—and then winds up being strictly figurative. Nietzsche worries the problem of a future being but won’t talk about the reproduction path to that being. When he says he wants “giving birth” to have an elevated sense, he sounds too squeamish to think about the unelevated sense of the process.
Take the comments about women in Beyond Good and Evil: for all Nietzsche’s sarcasm about romance and the sexual fulfillment that he sees feminists demanding “with medical explicitness,” he barely acknowledges the biological outcome of women’s relationship to men. All this “sex” and hardly a word about babies. When he does mention children he speaks respectfully of their mothers, but only as they figure in their children’s lives, men and reproduction having been shuffled offstage.
Nietzsche’s silence about reproduction could be laughed off as pathological if it weren’t so relevant to his promises about future human beings. Whether or not his silence is a symptom, it’s also a gap in his reasoning. If he refuses to talk about birth and babies, except in the “elevated sense” of the words, then where does he expect the future to come from?
What Nietzsche does wind up talking about in Beyond Good and Evil are not individual births but patterns of birth, populations that either remain pure or mingle, stand firm under siege or achieve enough prosperity to loosen up and become diverse. Sometimes the terminology is genetic, and he seems to be peddling nineteenth-century racial theories:
In an age of disintegration that mixes races indiscriminately, human beings have in their bodies the heritage of multiple origins, that is, opposite, and often not merely opposite, drives and value standards that fight each other and rarely permit each other any rest. Such human beings of late cultures and refracted lights will on the average be weaker human beings.
But just when you think you’re hearing another repellant coot grouse about miscegenation, Nietzsche twists the gloomy forecast around:
When the opposition and war in such a nature have the effect of one more charm and incentive…then those magical, incomprehensible, and unfathomable ones arise, those enigmatic men predestined for victory and seduction...They appear in precisely the same ages when that weaker type with its desire for rest comes to the fore: both types belong together and owe their origin to the same causes.
Ethnic, social, and racial mixing is the problem but also its own solution. Which type emerges is a matter of chance—another reason why Nietzsche won’t pin his predictions down.
The diversity in a civilization doesn’t have to depend on genetics. It can happen when a culture escapes poverty and permanent warfare: “A type becomes fixed and strong through the long fight with essentially constant unfavorable conditions”: so purity of hardship accomplishes as much as purity of pedigree. “Conversely,” he writes, “we know from the experience of breeders that species accorded superabundant nourishment…soon tend most strongly toward variations of the type and become rich in marvels and monstrosities.” Whether variation comes from parentage or comfort, it will yield odder specimens both good and bad.
I started out naming another variation that has been in New York’s air, which is the range of interpretation of the attack on the Trade Center. One example: George W. Bush immediately called the attack “cowardly.” Within a week Michael Wolff replied in New York magazine that whatever driving an airplane into a building may be, it’s not cowardly; Susan Sontag said more acidly in the New Yorker that the cowardice was American and anyway that courage is “morally neutral.” These distinct assessments of a single fact begin not as anyone’s mistake but in the distinct ideas of courage in different traditions and histories. When Nietzsche says that we are determined “by different moralities,” he is describing a circumstance in which all three judgments are using the word correctly. For one form that variation takes is jumbled moral discourse. Nietzsche says that under harsh conditions that don’t let a species vary, language too tends toward uniformity. Communication is transparent. “The greater the danger is, the greater is the need to reach agreement quickly and easily about what must be done.” When conditions permit people to deviate from the norm, so does their language.
Modern moral psychology, for instance, is the legacy of antiquity and Christianity, industrialized capitalism, but also a century’s worth of psychological science. So “courage” does mean (as the president meant when he denied it to America’s attackers) a state identical with all other virtues, including philanthropy and peaceableness. And it means (what Wolff seems to have had in mind) one virtue separate from the others, associated with pride and persistence; and it’s something you can describe without moral theories (Sontag’s view), a condition neither praised nor blamed in which one does not let fear inhibit action.
As I read Nietzsche, the future begins not so much when odd specimens are born as when formerly unnoticed cases, people of odd sentiment and insight, play with the distance between what they mean and what everybody else is saying. The future will differ from the past not because of any facts you can guess in advance—the disappearance of morality is not a fact—but because the existing facts turn out to fit new interpretation. The guilty conscience used to be thought of as the perception of something wrong you had done, but now the joke is that you can also call it the expression of great inner power; and so on.
Call this a future in which morality shades into a parody of itself, and the future burbles along still looking further ahead, pretending nothing has happened. (Something is always about to happen.) There’s a side of Nietzsche, the buffoon in him, who teases that future along by mocking the complacent moral vocabulary of the present. This quotable Nietzsche is hard at work in Beyond Good and Evil, a book obsessed with tossing our moral vocabulary around until it kaleidoscopes into bright new colors. A certain kind of wisecrack pervades the book:
A curiosity of my type remains after all the most agreeable of vices—sorry, I meant to say: the love of truth has its reward in heaven and even on earth – […]
English happiness—I mean…comfort and fashion.
We are accustomed to lying. Or to put it more virtuously and hypocritically, in short, more pleasantly: one is much more of an artist than one knows.
Nietzsche has not avoided discussing literal pregnancy and parturition out of squeamishness, but because literal talk is not what we need. The facts are as they will be, only needing the right new words to describe them; and the right new words are the same old jokes we know, but in the hands of a joker. Nietzsche wanted to take begetting and giving birth in their most elevated sense because they are metaphorical means of reproduction that make new metaphors. You can’t predict what the new parodies will be without inventing them, so it’s natural that he doesn’t try to describe the future (which will be the future of the language and the language of the future).
I started this piece with a couple of ideas in mind about Nietzsche, sex, and metaphor. After the World Trade Center’s destruction I wondered if the subject needed writing about. Why not put it off at a time like this?
On the other hand I didn’t want to write about the attack. I lived two blocks from the towers with my five-year-old-daughter when they collapsed. My family spent three weeks with friends before we could move back home; so my general thoughts about September 11th come with associations that are just my own and shouldn’t especially interest anyone else.
Still the disaster keeps seeping into our thoughts about every other subject; why not into a meditation on morality and prophecy? (I am writing before we see the ultimate effects of the World Trade Center attack, and with no desire to predict them.) Nietzsche kids about moral parody, but that doesn’t mean he’s not scared of it. And suppose the conditions for parodic moral discourse arrived but were not at all funny. Suppose the distractedness we’re seeing around town—people cooking meals and changing the oil and going to the movies, but as if putting those actions within quotation marks—suppose you called this state parodic. Can it be that our shock takes this form because such devastation requires an unambiguous reply, but our moral language can’t stand the strain? In that case even sincere efforts to speak morally will mock the possibility of moral discourse, the way it would mock ethical reasoning to ask Ted Bundy (no matter how sincere you were), “What if everyone did that?” or “How would you like it if someone did that to you?” The fervency of the response fails; or rather, fervency of feeling does not guarantee fervency of response if the response has no words to express itself with.
Imagine that not just some of the songs you grew up loving (“Space Oddity,” “Revolution”) had been sold to commercials, but all of them. The music that read your mind and spoke it now stands for ginger ale and arch supports—which is funny, but coldly funny; and these are only songs. Nietzsche is picturing that kind of future for the most serious words we know. No wonder he warned that he was talking about “the most terrifying, most questionable…of spectacles.” He envisioned a time when “Resume normal activities” would be a sentence that slipped around on the reality it tried to grip and sounded like a joke just waiting for a punch line; also a time when military attacks have been codenamed “Operation Infinite Justice” because “justice” without a high-intensity modifier doesn’t sound like enough. I can understand him now, though I still don’t get why he called this state “perhaps also the most hopeful of spectacles.” In fact that line sounds more glib than ever—and Nietzsche on the whole sounds more glib than ever—but maybe this is just a sign that I should stop writing, before my desire to spank Nietzsche with a few hard moralistic words tricks me into making an inadvertent joke of the last serious words I have to reach for.
NICK PAPPAS teaches Philosophy at City College of New York. He is currently working on a book on the nature of cause and effect in Nietchzes writing.
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Literature & Power: Writing about Politics, with John Ralston Saul, Oksana Zabuzhko, Shashi Tharoor, Tomás Eloy Martinez, Francine Prose, and Bernard-Henri Levy
JOHN RALSTON SAUL: The question we’ll consider today has three parts. Does the history of the last century offer much support for the view that the literary imagination has any special purchase on political wisdom? Can literature mitigate the pressures of ideology and nationalism, or is it destined to be their servant? Do writers have any special responsibilities beyond those of other citizens? Since it’s my job to set the tone, my answer would be that there are no answers to these questions. That’s particularly apparent to those of us who come from the twenty-odd supposed Western democracies, because we have by far, I think, the largest literary class in the history of the West. It has more freedom, even though we are unhappy, to express itself. And yet it seems that we have no effect, almost no influence, on the broad reality out there. Why is this the case?
Actually, it seems to me that there are three possibilities for writers. You can throw yourself in at a key moment and give language to people when they need it. Or you can be stubborn: Even though you know language won’t change anything, you just want to be counted on for having assumed the obligation and occupied the public space. In a sense, what we’re doing is providing signposts on the “darkling plain,” if I’m allowed to quote a very romantic poem. And the third possibility is to attack the language in place, whether it’s through fiction, or poetry, or essays: to say that the language in place is in effect an ideology, and we have to find some new form of language that can break down the language in place and make it possible for people to feel that they can change things.
We have with us today Tomás Eloy Martínez, who felt the obligation to go into exile, to stay in exile from Argentina, and to create a literature that would allow people in Argentina—and then around the world—to understand better what had gone wrong. We have Oksana Zabuzhko, who has just lived through a remarkable opportunity in Ukraine to be part of the Orange Revolution, in which language and stubbornness combined played a major role. Shashi Tharoor is a writer, biographer, and Undersecretary-General of the United Nations, and therefore lives on that undefinable line, or tension, that joins literature to power. Francine Prose, who of course is American and writes from within the American experience about much more than the American experience, writes to change the understanding of this civilization, to understand not just what’s happening but what it actually means. And Bernard-Henri Lévy set about breaking up the patterns of thought and language in France. He was pretty successful—which is why people were enraged. And then he felt the obligation to go outside his own society and speak out about Bosnia, Sarajevo, Iraq, Pakistan.
OKSANA ZABUZHKO: When I first read the title of our panel, what immediately came to mind was an episode from the last day of the Ukrainian Orange Revolution. Those of you who watched TV reports during those days might try to picture this scene: late night, in the city’s downtown, on the seventeenth day of the uprising, some two million people around, exhausted yet intoxicated with a sense of victory, with the results of the fraudulent election. And on the stage in the middle of the square, Yulia Tymoshenko, now the country’s prime minister, addressing the crowd with tears in her eyes: “The days of the revolution will forever stay in our history, we will cherish them in our hearts,” and this striking phrase: “We’ll do a book about it!” A strange statement for a politician, and sort of naïve: What kind of a book? Who was going to write it? The days of the uprising are shortly going to produce tens if not hundreds of books of different genres, so why single out a particular one?
The message was clear. Ms. Tymoshenko was promising to turn the seventeen-day personal experience of love and faith into a story, a narrative to be memorized and told possibly for generations. A good politician never fails to tell people exactly what they want to hear. True. What bigger prize can you offer those who have been challenged by the severest of threats and have overcome them than to make a story out of his or her experience? People want their lives to make a story. Every human being has this need, if only to make sure that his or her life makes sense. Long before the appearance of writing, a story told then disseminated has been taken as indisputable proof that the events in the narrative were worth living through. “I’ll make out of your life a narrative which gives you meaning.” This sentence has an allure which, for the nonreligious mind, verges on the promise of salvation.
This thought occurred to me some nine years ago when I published my first novel—a confessional story about a broken relationship, about a woman intellectual with an identity crisis—which turned into the biggest literary scandal of the ’90s in Ukraine. My greatest shock came not from critics proclaiming me a witch who deserved to be burned were it not for our civilized times, but from crowds of enthusiastic female readers, ranging in age from their early twenties to their early sixties. They responded with the same exclamations: “This is my story. I feel as though I wrote it.”
Their response was something I would never have predicted, if only because the narrator’s story was anything but typical. What made it so intimately recognizable for so many were the feelings. That’s where the true power of literature lies. That’s what makes literature irreplaceable by any other human activity, even in our visual age. Once you buy feelings depicted in a book as yours, you are trapped. You trust the author, as he or she has provided you with invaluable testimony that you are not alone in this world. You let the author into your inner life. You accept his or her way of seeing things as yours, and without noticing, you get a ready-made mold for your feelings—words, ideas, dramatic collisions, language, which you appropriated on some subliminal level to shape your own life so that it too would be worth telling.
This is where the power of literature collides with that of politicians: Ms. Tymoshenko assumed that one book documenting the events would do as a narrative for hundreds of thousands of individuals. Authors are interested, or at least are supposed to be interested, in individuals. No political power in its extreme absolutistic version ever extends further than making people believe they feel what they really don’t. The target is attainable, as we all know only too well, both from the twentieth-century history and from the present. By spending billions on the media, you can instill fear and anxiety. You can make people believe their lives are not full until they buy a Ferrari, or will be all messed up until they vote for Mr. So-and-So, to skip more gruesome examples. What you can never do, though, is endow a person with a sense that he or she authors his or her life as the protagonist of a story worth being shared with other people.
In a Persian fairy tale, a king addresses a foreigner with a remarkable demand: “I give you a year to tell me a story, but you should only tell what happened to you, and if you tell me what you heard from someone else, I’ll cut your head off.” I find this a fascinating requirement—a dream of a privilege never granted to a living human being. None of us has a year to turn our whole life into a narrated story, and no devoted listener, not even our dearest ones, would agree to spend that much time to help us make sense of our lives. This fairy tale presents the most perfect image of the benevolent, ideal power, as perceived from the standpoint of an individual. Power as it should be: a ruler who not just allows but orders you on pain of capital punishment to be your own author.
In real life kings act exactly the opposite. It’s in literature alone that we can still find the remote reverberation of ideal power cherishing and celebrating an individual self. Literature tells us what happened to someone else so that we are able to understand what’s happening to us. The trouble starts when writers try to play earthly kings and talk to the masses. The tempting advantage of such a politically powerful position is that it always implies immediate gratification, while the power of literature has a long-term effect and may not become visible until after the writer’s death. Writers and politicians live in different time modes—an extra reason not to confuse the two parallel circuits, which by definition should stay apart. If Ms. Tymoshenko asks me to write the book that she has so precariously promised to the crowd, my obligation would be to say “No, thank you.”
SHASHI THAROOR: Oksana reminds me that the relationship of literature to power was brought to light most famously in the election of that longtime dissident Václav Havel to the presidency of Czechoslovakia. Words, he said at the time, can prove mightier than ten military divisions. The word “solidarity,” Havel said, was capable of shaking an entire power bloc. Words have the power to change history. That was an interesting thought, and he certainly was an extraordinary example of it, but it didn’t work like that half a world away in Peru where Mario Vargas Llosa, the eminent novelist, believed that as an author, he had a “unique understanding of the people, their needs, their concerns, their spirit.” So he ran for president, and lost. Though other writers have assumed positions of power in their countries, and many have demonstrated the power of words to shake governments, serious novelists and poets have generally been unsuccessful in determining their readers’ political destinies. After all, the only president who can lay claim to a best-selling novel is Saddam Hussein.
As an Indian novelist, I find that literature’s relationship to power is particularly complex in countries like mine. Most developing countries are also formerly colonized countries, and one of the realities of colonialism is that it appropriated the cultural definition of its subject peoples. Writing about India in English, I could not but be aware of those who have done the same before me, others with a greater claim to the language but a lesser claim to the land. To think of India in the English-speaking world even today–and despite the exception of Salman Rushdie and others who followed him–is to still think in images conditioned by Rudyard Kipling and E.M. Forster. But their stories are not my stories. Their heroes are not mine. And my fiction, rather consciously—perhaps self-consciously—seeks to reclaim an aspect of my country’s heritage for itself, to tell in an Indian voice a story of India. And let me stress: a story of India, for there are always other stories and other Indians to tell them.
How important is such a literary reassertion in the face of the enormous challenges confronting a developing country? What does it have to do with power? Can literature matter in a land of poverty and suffering? I believe it does. We’re all familiar with the notion that man does not live by bread alone. In India and elsewhere, I’d argue that literature and the telling of stories are indispensable to our ability to cope with that mighty construct we call the human condition. After all, why does man need bread? To survive, but why survive if it’s only to eat more bread? To live is more than just a sustained life; it is to enrich and be enriched by life. Our poorest men and women in the developing world feel the throb of literature in their pulse. They tell stories to their children under the starlit skies, stories of their land and its heroes, stories of the earth and its mysteries, stories that have gone into making them into what they are. One responsibility of literature in a developing country must be to contribute toward, to help articulate, and to give expression to the cultural identity of the postcolonial society. Both colonialism then, and arguably globalization today, have fractured and distorted cultural self-perceptions. Development will not occur without a reassertion of identity: This is who we are; this is what we are proud of; this is what we want to be.
But those who have taken political roles in many developing societies also seek to seize this process by controlling the form, the shape, and the content of that identity. They seek to use their power to define the identity of their society or their culture in terms acceptable to the state. Now the task of the writer is to find new ways and provide old ones of expressing his culture, just as his society strives in the process of development to find new ways of being and becoming. This involves, in India’s case, resisting the notion that Indian identity can be narrowly defined in any one set of terms. My own novels speak of an India of multiple realities, and of multiple interpretations of reality. I once said that if we had to do an Indian version of the American slogan E pluribus unum, it would have to be E pluribus pluribum. Throughout my fiction runs an acknowledgment of the multiplicity of truth and a consciousness of the many truths that have helped give shape and substance to the idea of India. So in speaking of a cultural reassertion of identity, I do not want to defend a closed construct. I believe Indians would not become any less Indian if, in Mahatma Gandhi’s metaphor, we opened the doors and windows of our country and let foreign winds blow through our house.
My compatriots in India and I have been fortunate in having been free to express ourselves, but we cannot forget that the developing world is full of writers who have to function in societies that do not grant them this freedom. Writers in some developing countries have to cope with the perception that development and creative freedom are incompatible—that literature, for instance, must serve only the ends of a society as defined by the government, or operate only within the boundaries of the permissible as defined by the social or religious authorities. For such writers, the function of literature becomes much more than the creative rendering of social observations. In societies where truth is what the government or religious establishment says is true, literature must depict alternative truths that the culture needs to accommodate in order to survive. The paradox of the power of literature is that only when it is persecuted does it show its true colors. So it’s probably no accident that some of the world’s most remarkable literature in recent years has been introduced by writers who are either in exile from oppressive political systems—Gabriel García Márquez, Milan Kundera, Breyten Breytenbach—or struggling to hold up a mirror to the oppressive societies within which they live—Nadine Gordimer in South Africa, Neruda in Chile, Havel himself. Literature has always had the potential to raise the awkward question, to awaken the dormant consciousness, and therefore to subvert the established order, which may explain, despite the quote from Havel with which I began, why good writers rarely have the opportunity to make effective presidents. They are better at revealing than at ruling.
TOMÁS ELOY MARTÍNEZ: Michel Foucault says that power is a relationship of forces, or, more precisely, that all relationships of forces are relationships of power. He makes it quite clear that “force” here is plural. Foucault says that the set of factions permits the construction of a list in which there is neither oppression nor possession, but rather modifications in values. Everything acts upon everything, everything shifts. Literature is particularly unstable. It is that which is unstable, uncertain, which we don’t know how to label. Literary criticism can classify certain texts, but what the work of the imagination is for one reader today will not be the same in two hours or tomorrow. Neither is a text the same for one who reads it in Tokyo, Buenos Aires, or New York at this very moment. It is possible to classify a literary work, stratify it, reduce it to a mere story. But any such operation will always be provisional because the work is a relationship in itself. It is an occurrence and constant mutation. It is transfigured every time it is seen, and it affects us in a different way every time we look at it. William Faulkner said that he used to read Cervantes’s Don Quixote de la Mancha once every two years because he always encountered a different book.
In the last quarter century, must has changed: the failure of the Sandinistas in Nicaragua, the fall of the Berlin Wall, the atomization of the Soviet Union, the destruction of the Twin Towers, and such lamentable consequences as the invasion of privacy under the pretext of terrorism and the abominable torture at Abu Ghraib and Guantánamo. From the sexual liberation of the ’60s, we have entered into an era of repression, control of action with actions upon actions. These are times in which reality is read as it is not. Saddam Hussein appears in the place where Osama bin Laden should be. And the empty arsenals of Iraq appear where it was said there were arms of mass destruction. Reality is slippery, mercurial. It is no longer possible to speak of fighting political power because power also moves from the army to corporations to drug dealers to money-lenders to weapons traffickers to politicians who build fortunes at an impressive speed in order to eventually return them to the army, to weapons traffickers, and so forth.
Today, perhaps, we must go in the direction of reconstruction, and by this I mean the attempt to recover the imaginary and the cultural traditions of a community. Once appropriated by the novel, it is given a different context, a new life. One of the secret forces of culture is its capacity to strengthen itself with adversity, to elude censorship, to tell its truths and continue incorruptible and disobedient when all those around remain silent or submit. The diverse strategies have attempted to silence culture’s uncomfortable voice. Makers of culture have been repressed by imprisonment, the stocks, by burnings at the stake, with false confessions like those of Galileo before the inquisition and those of Sergei Eisenstein or Isaac Babel before Stalin.
One of the latest strategies of political power has been to simulate indifference. Each time culture raised its voice, power did not hear it. When power declares itself illiterate, when power does not read, writing does not harm it. Some neo-liberal democracies have assimilated that lesson. The philosopher Baruch Spinoza was asked, “How much can a body do?” Now we ask, “How much can a text do?” Novels do not change the world overnight, but they can recover the needs of the community, not to invalidate them or to idealize them, but to recognize them as a tradition, as a force leaving its sediment on the collective imagination.
FRANCINE PROSE: I think the question of what the writer can and should do about politics and power and the power of the state has entirely to do with what kind of writer one is. The essayist or polemicist has one kind of responsibility, and when I write essays now, as an American I feel that my responsibility is to say I live in a house in which a crime has been committed, and further crimes are being planned. I don’t for one moment imagine that I can stop these further crimes from happening by saying it, but I do so partly to preserve my own sanity, to preserve the sanity of others who are noticing what’s going on, and also to try and keep what tiny shreds of credibility our culture and our country have in the rest of the world.
I write for papers in this country and abroad. Earlier in Iraq war, I was living in Italy, and a newspaper in the United States in New York asked me to write an essay about what it was like to be an American in Europe during the war. And I said, among other things, that I felt that the Italians treated us the way you would treat someone you basically liked, but who you knew had a serial killer in the family. And I didn’t mean just George Bush, I should point out. The newspaper said, “We can’t run that line.” And I said, “Yeah, I knew that was going to happen.” And then later they said, “Actually, we can’t run the essay.” And I kind of knew that was going to happen too. I feel that I have a responsibility to let people here and abroad know and to get things right.
When I’m writing novels, I feel a different kind of responsibility. As we all know, polemic is the enemy of literature because the polemicist feels the need to distort language and character for a particular agenda instead of writing the most beautiful language or the character that’s most true to human nature, regardless of whether this truth goes against that particular agenda. Consequently, people say there’s no such thing as great political art. But of course that’s not true. Recently I saw the new production, the new translation of The Threepenny Opera on Broadway, and I was shocked and terrified. What made the play so exhilarating and so terrifying was how modern it seemed, how topical it seemed; it could have been written yesterday. As most of you know, Hitler shut down production on The Threepenny Opera, and everyone connected with the new has been joking that if it gets shut down, we might choose to leave the country the way Brecht and his associates did.
The novelist, the realistic novelist, wants to write about what we call human nature and society, and I think it’s impossible to write realistic fiction without talking about those two things. I also think that literature of the past says as much about politics as the most polemic fiction. I think that if you read enough Balzac you can pretty much figure out how Dick Cheney’s mind works. I think if you read Moby-Dick and think for a moment of Captain Ahab as our current administration, you can kind of tell where the ship of state is headed. And if you read something like Thomas Pynchon’s Gravity’s Rainbow, you begin to realize that your most paranoid fantasy will turn out to be the truth.
Lately, when I read literary journals or magazines, or even live in this culture, I feel as if we’re involved in a plane crash—a big plane crash—and all the other passengers are aeronautics engineers. They’re saying, “You know, I don’t really like that little whistle I’m hearing,” or “The engine sounds funny to me.” But still, we don’t have any choice. We can’t actually get off the plane; we can only stay on the plane. The hope is that what we write during this particular journey, if that’s what it happens to be, will survive the crash, will outlive us, and will be useful to future generations and to people in other countries.
I’ve been reading more history than I have fiction, and I’ve been reading in particular books about Hitler, books about Stalin, and books about the dirty war in Argentina. I’ve been reading them the way a hypochondriac reads health newsletters, looking for the warning signs of what could go wrong. One of the books about Argentina describes the way in which the generals perverted the language, and that it’s extremely important to listen to the language we’re hearing and to listen to the way our government is using the language, and to pay attention. At the same time, what I want my own children to read, what I want all young people to read, is great literature—and also, for example, books about Vietnam, because those are books about ways in which writers in particular and a population in general did alter government policy and did make a difference.
BERNARD-HENRI LÉVY: I know that French writers are supposed to speak too long, so I will try to be short. I don’t think that the power of literature has to do, first of all, in any sense with identity, and with national identity. We know, from the origins of literature, that literature, when it is good literature, has nothing to do with identity. The great writer Joyce said that he wrote in Unglish, not in English. Dante said that he did not write in Italian, did not write in French; he invented it. I don’t think that the responsibility of literature has anything to do with national belonging. Milan Kundera makes a distinction for every writer between the little context and the grand context: the little context of the national environment, which does not say anything, which is the worst advisor of the writer, and the grand context, which has nothing to do with national identity.
I don’t think that literature and its power have anything to do with humanism or even with good feelings. I know that we are in a country where there is sometimes a tendency to drive the writer into political correctness, to practice a sort of ethical cleansing, to oblige the writers to be good guys. The best American writers—Norman Mailer, Truman Capote, Flannery O’Connor—are not good guys.
I don’t think that literature has anything to do with positive thinking. As everybody knows, Céline, one of the greatest writers of the twentieth century, was one of the most infamous Nazi collaborationists. How did the first Céline become the second one? He became the second one at the very moment when he became a positive thinker. The first Céline that there is no solution, that the human being was a failed species, condemned to radical evil, that there was no exit, and that role of the writer was to explore this no-exit road. Then came another Céline who remembered that in a former life he was a doctor, and that the job of the doctor is to cure the illnesses of his brothers in life. He said, “Let’s be positive. Humanity is ill. I’m going to identify the illness. I’m going to find the good medicine and I’m going to impose the good medicine on the ill patient.” And the way to do that was to exterminate. The bad virus was the Jews.
This does not mean of course that literature has no responsibility and no power. There is an important distinction between the power of literature and the power of writers, which are two very different things.
MARTÍNEZ: I have a comment and a question. We, most of us, talk about power as a political problem, power as a political force. But power is a relationship. We can find power in love, power between father and son, power between boss and employees. We can see sexual abuses as a derivation of the problem. Literature may have nothing to do with power, as Bernard-Henri said, but power has a lot to do with literature. Power silences it, and censors it. At the same time, Borges supposed that censorship is good for literature, because literature is like water that finds a way to escape the power and, finding a way, comes to the real literature—not the photography of reality, but a different kind of reality.
And the question is for Francine: How does power use the language? A teacher of Simón Bolívar discovered that the use of some words in the wrong way perverts the words: Using “democracy” is different if Nelson Mandela uses it than if a person in the Bush Administration uses that same word. “Freedom” was different when Reagan used it than when someone else uses it. Power moves the meanings of the words.
PROSE: One of the ways that happens, as you said, is distortion and euphemism. I’ve been reading Nadezhda Mandelstam’s great memoir of the Stalin years, and one of the things she says that seems so modern and up to the moment is that people stopped using the word “conscience” and only used the word “patriotism.” Now we’re hearing “patriotic” and this hideous misuse of “freedom.” But the word “conscience” is almost never used in political discourse; it just doesn’t seem to be relevant.
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Distributing your apps to others can be done in different ways, but the short of it is that you need:
- Ensure users have installed the coraline package;
- To get users to install your app;
- To allow users to launch your app.
Installing coraline should be relatively straightforward, and it may already be available on the target system. Short version: point them to the coraline setup/downloads page for that.
Prepare and Deploy your App
How to distribute your application.
The easy way
Update: a new, much easier way to prepare apps for deployment is available. If you’re using cordova or ionic, then it’s only a matter of installing the cordova-linux platform (check the requirements on the platform page–basically you need cmake, coraline and some way to make deb/rpm or both).
From the top level project directory, you can now add the platform and build it with two simple commands:
$ cordova platform add \ https://github.com/psychogenic/cordova-linux.git $ cordova build cordova-linux
or, with ionic:
$ ionic cordova platform add \ https://github.com/psychogenic/cordova-linux.git $ ionic cordova build cordova-linux
which will transpile the project.
By the end you should have some deb, rpm and/or zip files in platforms/cordova-linux/packages
You don’t need to have cordova or use the linux platform system, as all we really need is a bundle (deb or rpm or zip) with the appropriate content in the right spots.
A walk-through of bundling an app for distribution:
What to bundle
Coraline handles everything but your custom code, so all you actually need to distribute is your HTML, JS and associated resources.
If, say, you’ve created an ionic project and transpiled it, you wind up with a self-contained www/ directory. This is what you will distribute.
In addition to your actual content, it’s a nice touch to customize the experience a bit and to allow your users to launch the app from the system menu or the command line.
Softlinks to coraline
Coraline implements a feature that simplifies launching and keeps the GUI layers of the OS happy.
If you have an application, say “My Super App” and you have bundled your content into a directory called mysuperapp, then (when installed in the right place, see below), creating a softlink with the same name:
$ ln -s /usr/local/bin/coraline mysuperapp
will allow you to launch coraline using your custom name, without any additional arguments. Thus
will be equivalent to typing
$ coraline /usr/local/share/coraline/mysuperapp/index.html
with the added benefit that you’ll be able to associate your own custom icon to display in the task bar.
Where to install
In theory, these files could be installed anywhere on the system, but you are encouraged to give the parent directory a unique name, and have it installed in the coraline content directory–see the “softlinks” section, above, to know why this is a good idea.
This is probably /usr/local/share/coraline/content but can be found on the system using pkg-config:
$ pkg-config --variable=contentdir coraline
How to bundle
Though you can distribute everything as a plain tarball, using a packaging system will allow you to specify dependencies, like coraline or any of the optional plugins, and make sure users have everything they need before launching your app.
See the video above for a look at that.
How to launch
If you’ve setup a softlink to coraline in your bundle then, in addition to getting a custom icon, you get the opportunity to launch you app with a unique name, and no parameters:
Even without going through the trouble of softlinks, launching your app is as simple as running coraline with a parameter to point it to the right startup file. If you’ve installed under the coraline content directory, as described above, then you can omit the full path and just issue:
$ coraline myapp/index.html
(assuming your parent dir is “myapp“, of course). This is great for testing, but an even better approach is to provide a suitable desktop link for your application.
For instance, on ubuntu this would be a .desktop file installed somewhere like /usr/share/applications that looks like:
[Desktop Entry] Name=MyApp Exec=myapp Terminal=false Type=Application X-Ubuntu-Touch=true Icon=/usr/local/share/coraline/content/myapp/path/to/icon.png
I stuck this in that applications directory, and now searches for “MyApp” yield this:
Creating the package
Once you’ve got the entirety of your app under a single directory and ready to deploy, along with any additional resources like desktop shortcut, system icons etc, package it up as a deb (for Debian/Ubuntu), rpm or whatever is appropriate for your platform.
The most important, and useful, part of this process is that you can specify that your package depends on Coraline and any optional plugins, so that you’ll be certain your users are all setup prior to trying to launch the app (and sending spurious bug reports).
Exactly how you go about creating these bundles is left to other, better equipped, resources but the video at the top of this page shows you an example procedure, using cmake/cpack.
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What is the electronic configuration of calcium in shells?
The Electronic Configuration of Calcium in the Shells is a topic that will be explored in this article. This article will explore the electronic configuration of calcium in shells and what it means for the stability of a particular substance.
What is the electronic configuration of shells in calcium?
The electronic configuration of calcium is 3. 5-3.6-4.
Why does the electronic configuration of calcium in shells change?
The electronic configuration of calcium in shells changes from a locked configuration to an open configuration when the outer layer is removed. This happens because two calcium ions close to one another move about 2 x 10-7 m away. This electrically neutral change does not generate any heat or energy. The second type of ionization is redox-ionization.
This also changes the electronic configuration of calcium ions, but the electronic configuration changes from an open to a closed configuration. In other words, the electrons are removed from one portion of the shell and added to another portion of the shell. This is another electrically neutral change that does not generate heat or energy.
Calcium metal melts at around 1100 degrees C, and this is too hot for all of the different forms of ionization to be wholly separated. Therefore, calcium metal does not melt when you decrease the temperature below 1000 degrees C. If you increase the temperature beyond 1100 degrees C, all three types of ionization start to coincide, and calcium metal will melt. The behavior of calcium metal is more complicated than iron or sodium metal because two different oxides form on it.
They give two different responses to heat treatment. Calcium oxide (CaO) and calcium hydroxide (Ca(OH) are both oxides of calcium while they are of different chemical compositions. Calcium oxide is a black, brittle, and dense material, while calcium hydroxide is white, soft, and hygroscopic. The definitions of the various forms of ionization that occur in calcium metal are given here: The first form to heat calcium metal is CaO which gives rise to a completely amorphous solid when it becomes fully melted.
How does the electronic configuration of calcium in shells change?
When calcium carbonate, CaCO3, is deposited in the environment and becomes shells of ammonium phosphate (NH4)2HPO4, it becomes a complex with three kinds of ions. One atom of calcium has a central ion vacancy and two bonds to oxygen atoms. The compounds are not stable when wet because the water molecule displaces one of the oxygen atoms from its double bond.
The two types of calcium ions are sensitive to water and will react with them, but the calcium carbonate cannot be broken into these ions. The type of calcium ion depends on the kinds of bonds between it and other atoms. In this case, the double bond makes the second type of ion, Ca2+/2 + HO2-. These two ions react with water like CaO(aq) (CaO+2HO-), also called a hydronium ion. The reaction can be written.
Many other ions have water-insoluble calcium compounds as their anions. The hydroxides of these ions are also called soluble calcium compounds or simply soluble salts. These include carbonates, bicarbonates, and silicates (carbonates and bicarbonates are bivalents).
The structure of Ca2+ is shown below. This ion consists of two hydrated calcium cations (Ca2+) and three hydroxide anions (OH-). Their nonbonding electrons and the OH bind the two calcium ions- ions are held together by their oxygen atoms.
ground state electronic configuration of shells in calcium
Calcium is the most abundant mineral in Earth’s crust, and it takes on different forms of calcium compounds. The electronic configuration of calcium shells depends on the ground state electronic configuration of atoms in the shell. For example, a divalent cation, sodium, or potassium will organize into octahedral coordination geometry.
In contrast, a cation with a higher oxidation number, such as magnesium or barium, will have tetrahedral coordination geometry. The ground state is the lowest energy configuration of an atom and cannot be altered by outside influences. An atom that is not in its ground state has a higher energy level it can attain by absorbing or emitting radiation. This process of absorbing or emitting radiation is known as spectroscopy. Spectroscopic signatures are used to detect particular materials on Earth.
Calcium is the most abundant mineral in a shell. It was also the first component of shells that evolved. Animals used caves to create calcium compounds, which form the basis for shells, eggshells, and teeth. The calcium hypothesis of tooth development suggests that human teeth develop similarly to other animal teeth. The discovery of recent evidence for the evolution of the calcified
tissues in the mouth supports this hypothesis. This study suggests that the embryological development of calcified tissues may be an essential factor in tooth development.
Mineralization will increase when calcified tissues develop and become much more critical in tooth development than in other bones. Some bacteria can cause changes in the oral cavity that promote tooth eruption. These bacteria include strains of Streptococcus mutants and groups of Lactobacillus species (15,17). The role of these bacteria in dental caries could be understood if these organisms’ pathogenicity was more fully characterized.
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The GEOTHERMICA and Joint Programming Platform ERA-Net Smart Energy Systems (JPP SES) workshop for national and regional Programme Owners and Program Managers took place on 16 October 2020. The aim was to identify ways forward to accelerate innovation for heating and cooling as an essential part of the energy transition. This three-hour event developed initial thoughts for the new focus area, taught about challenges in the field of renewable energy heating and cooling and engaged respective stakeholders in the new endeavours.
Review of the Event
The morning session, moderated by Ludwig Karg
from JPP SES, aimed to motivate countries to organise participation in a heating and cooling activity, a possible joint call in 2021. The warm welcome was given by two inspiring figures from geothermal and smart energy systems worlds: Guðni A. Jóhannesson
, Coordinator of ERA-Net GEOTHERMICA
and Fredrik Lundström
, JPP SES
The keynote presentation by Javier Urchueguía, Chair of European Technology Information Platform (ETIP) for Renewable Heating and Cooling (RHC) showcased their accomplishments on "Research and innovation challenges in Renewable Heating and Cooling", followed by five diverse representatives of IEA Technology Collaboration Programmes on district heating, heat pumping technologies, solar heating and cooling, and energy conservation and energy storage, who commonly agreed that joint efforts in the field of heating and cooling groups is essential now for further success in sustainable development.
By the end of morning session, Costanza Saletti
and Mirko Morini
presented a fascinating study on the status of the heating and cooling networks R&I within Horizon 2020. They stated that key drivers for future innovation in Heating and Cooling lies in digitalization, integration, decarbonization and resilience. The session was wrapped up by motivating pitches from innovative projects supported by the two ERA-Net communities. Jakob Worm
presented a pitch from HEATflex
, Holger Cremer from HEATSTORE
, Anna Nils-son from Flexi-Sync
and Herman Eijdems from Minewater
GEOTHERMICA and ERA-Net SES Teams inviting to join the journey
The afternoon session was moderated by Paul Ramsak, the co-leader on knowledge, strategy and support in GEOTHERMICA. This session was restricted to national and regional Programme Owners and Program Managers and was well attended, with more than 50 participants. The session contained a spotlight presentation of four lead interested countries Netherlands, Switzerland, Sweden, Spain and Germany. To engage the plenary discussion among other European program owners and building the way forward, attendees were participating in live-streamed polls to foresee the attitude of the national and regional rep-resentatives. The afternoon session was closed by a presentation of "Joint call on Heating and Cooling – Way Forward" led by GEOTHERMICA Office.
Accelerating energy technology innovation is crucial to meet energy and climate goals, to support eco-nomic growth, and to enhance energy security. As Paul Ramsak mentioned, he is dreaming of living in a world with no fossil fuels use, but the use of natural resources which can provide all cooling and heating needs sustainably. This should be not only possible in Iceland, but also in other European countries and worldwide. To achieve it, we need creativity, energy, and joint effort. The meeting successfully promoted the mission and positively engaged participants to get on board move forward in this endeavour.
Join us on our Journey
Speaker presentations can be accessed here
BACK TO NEWS OVERVIEW
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Although it is believed that managing your academic career is the most challenging phase in your life, if we look at it from a different perspective, being a student is the most complex challenge an individual has to go through to achieve desired objectives and, for that matter, to make dreams come true!
Why so? Well, let’s see, because as a student you are:
- Still growing and learning in the prime of your life
- Vulnerable to the inevitable changes that come your way
- Indecisive and uncertain about your interests
- Surrounded by several distractions
- Tremendous competition in every professional arena
- Dealing with constant societal expectations and pressures
The list doesn’t end here. Problems faced by students are a topic for a whole new blog!
But for now, as far as the life of a student is concerned, one way to sail through it is to set goals for yourself. It keeps you in the groove, keeps you moving, and motivated.
Again, setting goals is not an easy task in itself. It requires you to identify and understand your capacity, pace, interests, attention span, retention skills. Students usually struggle in setting their goals and, in the absence of such goals, tend to deviate from their interests in the subjects and hence look for Australian assignment help. But here are a few ideas for what kind of academic goals a college-going student can begin with.
Goals you can begin with and become better by accomplishing them
One of the basic requirements for a student is to be an interested reader, if not an avid one. You must train your brain to read for at least thirty minutes straight (this being an average of an intellectual). It increases your attention span when you are reading, which helps you stick to a topic with persistence and reading speed, which helps you cover more in less time and build your vocabulary.
For instance, your goals regarding reading could be:
- Read a couple of pages of a novel every day before going to sleep
- Reading the newspaper every day at a set time
- Reading about your favorite sports or any other extracurricular activity and the developments in them.
Loyalty towards a timetable
If you are setting goals for your academic purposes, you must use a timetable to regulate your study sessions and other activities in the day. However, your goal in such situations should be to stay loyal to the timetable you have created. Respecting the timetable would bring a sense of discipline in your life, which is again of great significance when it comes to professionalism and faring well in your respective careers.
Pick up an extracurricular activity or sport
Indulging your mind into an extracurricular activity or any sport is your mental ability to be constantly activated. Once you have had a study session for, say, two to three hours, your mind needs to focus on something entirely different for a certain amount of time to get rejuvenated. You can focus better the next time you sit for studying. Also, research has proved that when you are into a particular sport, your concentration and reflex levels increase, which in turn reflect on your academic performance. This also increases your mind’s exposure to different settings with the environment, helping you build on your adaptability.
From the perspective of a college-going student, here are characteristics of a goal that they need to consider before setting them:
characteristics of a goal
- Time-bound: A goal always has to be time-bound, i.e., it should have a specified deadline. Without a time limit to your goal, it will be as good as a regular day-to-day task that might not garner the extraordinary efforts you put in to achieve its successful completion.
- Relevant: As opposed to the minor goals you began with, the goals for a college student have to be relevant. That is to say that you might have to decide on how much time you would be spending on other activities and studying based on your performance. These goals should be relevant to the subjects you are in full swing in your college. Achieving them should put you in the position you dreamt of in your career objectives.
- Measurable: Goals need to be primarily quantified when it comes to academics. For instance, getting a score above 80 on every subject of your semester. This way, you can evaluate your progress and exactly know how much more effort you need to put in.
- Achievable: goals are neccessary to be realistic. And whether a goal is realistic or not is entirely up to your calculation and review of your academic performance.
Ideal examples of academic goals
Following are the examples of academic goals that possess the above-mentioned characteristics and are ideal for a college-going student!
Achieve and maintain a good CGPA
It is easy to score a good CGPA once, but maintaining it for the remaining semesters and having consistency requires dedication, hard work, and academic assistance from your mentors. You can modify this goal according to the academic environment. Plus, since this is a massive goal regarding its timeline and measurability, you can divide it into smaller goals such as assignment grade goals.
Complete graduation without any extensions
Being a college student requires commitment. You need to be dedicated to your current situation. It can make requirements to achieve your fullest potential. Completing graduation within the prescribed time limit is a straightforward goal that can be easily accomplished by actively and vigilantly participating in your curriculum. Again, this school is relevant in saving your time from any repetitions in your prime of life.
Focus on one degree/course at a time
This is not a goal per se, but it is often advised that you should focus on one degree or coursework which you have opted for at a time. Venturing into different courses will divide your attention and capabilities and have a chance of Luke not performing to your full potential. Although when it comes to multitaskers and overachievers, this is not a goal they would want to set, but generally, giving your undivided attention to one course shows devotion.
Learn a new language
Usually, most courses today offer a foreign language as a subject. This is because it not only gives you insight into the culture of a completely new nation but also opens your opportunities in case you wish to study abroad in the future. Moreover, a second language always shines bright in your resume.
Applying and doing internships
Doing internships while in college gives you opportunities to work and apply literary theories to the practical world. Its gives you the exposure and confidence you would require as a professional. Although this goal might not be feasible concerning your concerned subjects, there’s no harm in doing an internship. Plus, today, since the competition is cutthroat, you might be lucky enough to get a stipend!
Publish some research work before graduation
Getting your research published reflects your interests and dedication to the field. This will look good on your professional resumes and give you that sense of satisfaction that comes out of producing something utilizing your intellectual resources.
Make good connections within faculty and even outside
If you are an extrovert, this might not be a worthwhile goal for you, but it will help all the introverts or the students who face difficulties adapting to changes. Mingling with people from different backgrounds within your college and even outside your college will help you open up and be more approachable, which is crucial for the professional.
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BOSTON, Jan. 11, 2022 /PRNewswire/ — PostEra, a biotechnology company specializing in machine learning for preclinical drug discovery, today announced $24M in equity financing to accelerate medicinal chemistry and bring new cures to patients.
PostEra will use the proceeds to advance a series of partnered drug discovery programs, initiate its own internal drug discovery, and further develop its medicinal chemistry platform. True to its collaborative ethos, the company today also announced its multi-target strategic partnership with Pfizer, to establish an AI Lab.
The Clermont Group, an international business group headquartered in Singapore, led the Series A financing with participation from Breyer Capital, Lifeforce Capital and I2BF Global Ventures, alongside existing investors including Metaplanet, HOF Capital, Ace & Company, Pioneer Fund, and R. Martin Chavez.
“PostEra is excited to welcome the Clermont Group as a shareholder,” said Aaron Morris, CEO of PostEra. “We share the same passion for innovation and commitment to improve lives by accelerating the discovery of treatments for diseases.”
“We invest in businesses dedicated to the greater good of society,” said Sean Gardiner, senior vice-president at the Clermont Group. “PostEra is at the leading edge of advancing medicinal chemistry through its advanced AI technology. We look forward to working alongside the team to build the industry’s leading drug discovery platform.”
Over the last 18 months, PostEra has proven its platform on a wide variety of drug discovery programs by tightly integrating the Design-Make-Test cycle of medicinal chemistry. Results include the rapid development of COVID oral antiviral candidates via COVID Moonshot, the advancement of several drug discovery efforts with biopharma partners, and the launch of Manifold as an industry leading synthesis platform.
“PostEra has made large strides in demonstrating the real utility of our AI-first medicinal chemistry platform to accelerate small molecule drug discovery,” said Morris. “We have a proven record in deploying our machine learning technology to unify the Design-Make-Test cycle of medicinal chemistry and, vastly improve upon traditional trial-and-error based approaches.”
PostEra was founded in 2019 and its technology is built on pioneering academic research done by its founding scientists. PostEra’s technology addresses some of the key challenges in drug discovery R&D by integrating molecular design with chemical synthesis. PostEra advances small molecule programs through partnerships with biopharma, working on its own internal pipeline, and also offering some of its synthesis technology via its Manifold web platform. PostEra also launched and now helps lead the world’s largest open-science drug discovery effort; COVID Moonshot.
About the Clermont Group
The Clermont Group is an international business group headquartered in Singapore. Founded in 1986 by New Zealand-born entrepreneur Mr. Richard F. Chandler, the Clermont Group builds businesses in healthcare, financial services and aerospace. Further information can be found at www.clermont.com
View original content to download multimedia:https://www.prnewswire.com/news-releases/postera-closes-24m-in-new-financing-to-advance-drug-discovery-301457255.html
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Keeping Farm Records or Creating Farm Data? There is a Difference.
15 Jul 2021
Ask a farmer if their day is spent in the field or keeping the books. It depends on the time of the year, but overall, many would say their time is heavily spent in farm management. Are your customers keeping farm records or creating farm data? Changing the mindset from keeping farm records to creating farm data will help you become the trusted provider they rely on for financial decisions.
A collection of paperwork, even if on a computer, is simply keeping farm records. If the information is captured in a useable format it is so much more than a receipt to meet a regulatory requirement or a stack of papers saved up for the annual tax appointment.
In modern farming, sound business decisions are made based on historical information collected for years and possibly generations for each farm. Farmers are analyzing input costs, market numbers, soil composition, and of course, watching the weather report.
The modern farmer knows they are not only keeping farm records, but they are also building data. As an ag retailer, how are you building value and becoming their source of data? It is essential to provide customers with the technology tools to support and simplify data management for your farmer customers. That data is there to answer their daily questions and help them excel as the financial manager of their business. As they rely on your company for their trusted farm data, you have created a life-long customer.
Putting the right technology in customer’s hands solidifies a trusted technical advisor relationship. Find more information about Grower360 on our website and request a demo of what it can do for your business relationship with customers by completing the form below.
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While regulators are trying to restrict privacy in crypto, their efforts may be futile, according to privacy-centric protocol Monero's maintainer, Riccardo “Fluffypony” Spagni.
"The U.S. Internal Revenue Service (IRS) wants the same level of insight [into monero] as they have over digital dollars in bank accounts; however, cryptographers and researchers are always going to be one step ahead on privacy," Spagni told CoinDesk.
Launched in April 2014, monero (XMR) is a private, secure and untraceable cryptocurrency. The protocol allows transaction participants to obfuscate their identities and hide the amounts transferred from third parties, except for those they designate.
Protocols offering privacy have become the focal point of regulators and law enforcement agencies when the race among central banks to launch sovereign digital currencies is heating up.
Further, the U.S. Department of Justice (DOJ) published an extensive white paper, "Cryptocurrency: An Enforcement Framework", on Oct. 8, citing the use of anonymity enhancing cryptocurrencies (AECs) that use non-public or private blockchains as a risk to anti-money laundering programs and controls put in place to combat terrorism-related finance.
According to Spagni, who was lead maintainer of Monero until he stepped down last year, regulators' best bet is to apply controls at entry and exit points. "Payment service providers and merchant service providers are sorts of the points at which they can apply a degree of regulation. And that I think is feasible," Spagni said.
For instance, a payment gateway facilitating monero or lightning transactions could ask users to verify location and charge sales tax. Similarly, if the user is dealing directly with a merchant service provider, the merchant would employ necessary checks before approving transactions.
Besides, even if regulators succeed in developing some traceability solutions, monero is likely to fix the bugs, retaining privacy over the long run, according to one analyst.
"Untraceable cryptocurrencies such as monero are here to stay," Dr. Tom Robinson, co-founder and chief economist at blockchain analytics firm Elliptic, told CoinDesk in an email. "In the short term, it may well be possible to find exploits in these systems and trace transactions to some degree, but these bugs will be fixed."
Over the weekend, monero implemented an upgrade codenamed "Oxygen Orion," which includes a new ring signatures feature called compact linkable spontaneous anonymous group (CLSAG). That is expected to reduce transaction sizes by 25%, improving transaction verification times by 10% and boost security.
Perfect solution unlikely
An ideal world solution that limits backdoor entry into privacy protocols for regulators and law enforcement looks out of reach.
"A system of controlled access would be fantastic; however, the thinking, though not bad, is just flawed," Spagni said, adding that both well-meaning people and hackers could abuse the system.
Besides, regulators continue to struggle to establish controlled access in traditional finance, where paper money still offers some privacy. "Traditional financial institutions are already comfortable with untraceable payments in the form of physical cash," Elliptic's Robinson said.
In the days before the dot-com era, physical cash transactions dominated the global economic activity, and regulators and agencies relied heavily on active surveillance methods like monitoring behavior and actions to break cases. Currently, regulators and law enforcement agencies rely on passive surveillance like facial recognition systems, tracking bank accounts, and suspicious activity reports by financial systems.
Spagni said agencies need to step up their game and not rely on passive surveillance or influx of information, which "ultimately results in false positives."
There could be a better middle ground between regulators and privacy cryptocurrencies that facilitate legitimate financial investigations but avoid surveillance.
"Our position is that financial privacy is important, and people should be able to pay for day-to-day expenses without having to fear hitting regulators' radar and provide identity proofs," David Jevans, CEO of blockchain forensics firm CipherTrace, told CoinDesk in a telephone interview.
Monero shrugs off regulatory concerns
Monero has charted an impressive rally over the past few weeks despite the increased regulatory scrutiny and dour expert forecasts.
The privacy coin rose to a two-year high of $135 last week, marking an over 90% rise from the lows near $75 observed in early September. The cryptocurrency is currently trading near $120, up 22.3% so far this month, the highest of any crypto asset valued above $1 billion, according to data site Messari. Monero's price has increased 173% on a year-to-date basis while bitcoin has gained 60% over the same amount of time, according to CoinDesk 20.
CipherTrace's Jevans believes monero has largely tracked bitcoin's price, and the recent outperformance is mostly due to chart factors.
"Speculators, algorithmic traders look to have fueled the price rally," Jevans told CoinDesk, adding that people who care about monero haven't been involved.
"The overall sentiment of crypto as a whole has turned fairly bullish as of late with monero's gains simply outpacing those of other coins breaking out past some technical resistance at $95 and $115," Connor Abendschein, a crypto research analyst at Digital Assets Data, told CoinDesk.
Nevertheless, the price rally, regulatory inquiry, and potential traceability solutions could turn out to be net positives for monero. "It gets visibility in the market," Jevans said.
That governments and regulatory authorities are trying to clamp down on monero transactions suggests there is strong demand for the privacy token.
Abendschein, however, maintains that the cryptocurrency would lose ground if Chainalysis succeeds in “consistently tracing” monero transactions, while Jevans foresees privacy coins falling to the backwaters of crypto markets if they fail to comply with regulatory requirements.
That said, the international law firm Perkins Coie published a regulatory white paper a month ago, detailing how regulated entities can comply with anti-money laundering obligations while supporting privacy coins.
“The AML [anti-money laundering] risks of privacy coins, while real, do not require specific, tailored regulations that may pose an unnecessary risk of stifling privacy coins’ growth. Rather, virtual assets service providers (VASPs) can adequately address those AML risks by maintaining an effective, risk-based program. Allowing VASPs to support privacy tokens undercurrent, tested AML regulations strike the appropriate policy balance between preventing money laundering and allowing beneficial, privacy-preserving technology to develop,” the white paper said.
Regulated exchanges are already developing ways to support privacy coins in a compliant way. “Crypto exchanges that support zcash [also a privacy coin] are using Elliptic's products to assess risk on zcash transactions,” Elliptic’s Robinson told CoinDesk.
The leader in news and information on cryptocurrency, digital assets and the future of money, CoinDesk is a media outlet that strives for the highest journalistic standards and abides by a strict set of editorial policies. CoinDesk is an independent operating subsidiary of Digital Currency Group, which invests in cryptocurrencies and blockchain startups. As part of their compensation, certain CoinDesk employees, including editorial employees, may receive exposure to DCG equity in the form of stock appreciation rights, which vest over a multi-year period. CoinDesk journalists are not allowed to purchase stock outright in DCG.
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Last week the 2017 Nobel Prize winners in six different categories were announced. This month I continue to write about the winning projects in the science fields – physics, medicine & physiology and chemistry.
The 2017 Nobel Prize in chemistry was awarded to Jeffrey Hall, Michael Rosbash, and Michael Young for discovering the genetic and cellular mechanism behind circadian rhythms
Circadian is made from circa the Latin word meaning “around” and dian meaning “a day.” A circadian rhythm is the 24 hour cycle that plants and animals go through each day. There is time for rest, time for being alert. It turns out that the cycle is regulated by proteins created by the DNA in our cells, although light and temperature can effect your circadian rhythms as well.
You can learn more about the exact cellular mechanism discovered by this year’s Nobel winners but it is quite easy to learn about circadian rhythms on a bigger, organism scale.Here are just a couple of ideas:
- Grow some bean seeds in a sunny window and observe the motion of their leaves during a day. Put some of the bean plants in a dark closet but continue to watch the motion of the bean plant’s leaves. Do they follow the same cycle even without sunlight? Or try this with Mimosa plants, which close up their leaves at night.
- Monitor your own circadian rhythms. Take your temperature and blood pressure every hour for a couple of days. Do you see a pattern? What times of day is your blood pressure and temperature highest? Lowest?
- (This one is best done when school is out) Does your body know when to wake up? Instead of using an alarm clock or having someone wake you up, keep track of what time your body wakes up on its own in the morning. What time do you go to bed? More on sleep patterns and chronotype here.
Even astronauts on the International Space Station have to deal with changes in circadian rhythms since in their world the sun rises or sets every 90 minutes!
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Homeland Security Secretary Janet Napolitano, White House Cybersecurity Coordinator Howard Schmidt and FBI chief Robert Mueller will all be taking the keynote stage at annual RSA Security Conference and Expo.
The speaker lineup at this year's annual RSA Security Conference and Expo, underway this week in San Francisco, is packing some serious federal heat. Homeland Security Secretary Janet Napolitano, White House Cybersecurity Coordinator Howard Schmidt and FBI chief Robert Mueller will all be taking the keynote stage.
Mueller, speaking Thursday, will be discussing how law enforcement and the private sector need to work together to fight cyber crime, but Schmidt and Napolitano, were last-minute additions to the roster, so the subjects of their talks – taking place this afternoon and Wednesday, respectively – are anyone's guess.
Two cybersecurity mavens who served in previous administrations – former Secretary of Homeland Security Michael Chertoff, and former chief counterterrorism adviser at the National Security Council Richard Clarke – will be participating in a panel discussion scheduled for Wednesday: "Dealing with Sophisticated Threats in Cyberspace without Creating Big Brother," moderated by Quentin Hardy, national editor of Forbes magazine. Marc Rotenberg, executive director of the Electronic Privacy Information Center (EPIC), will also participate.
The hot topic at this year's event appears to be security in the cloud, with an emphasis on application development and an uneasy nod to the security impacts of social networking. The conference schedule includes 18 tracks and more than 250 sessions, including a brand new track, Data Security, that covers strategies, practices and technologies for classifying, tracking and protecting sensitive data in the cloud.
"Cloud services are clearly the next generation of information technology that enterprises must master," Jim Reavis, founder of the Cloud Security Alliance (CSA), a not-for-profit organization promoting best security practices in the cloud, said in a statement. "We have a shared responsibility to understand the security threats that accompany the cloud and apply the necessary best practices to mitigate them."
Yesterday Hewlett-Packard and the CSA took the wraps off new research findings detailing the potential security threats posed by cloud services. In a paper entitled "Top Threats to Cloud Computing Report," researchers found that, because Web sites in the evolving online social ecosystem rely on APIs to present data from disparate sources, they often suffer from what the report calls "weakest link security." That's where one insecure API can adversely affect a larger set of participants. Consequently, existing vulnerabilities "are magnified in severity in cloud environments," and "new, cloud-specific techniques put data and systems at risk."
Among the companies announcing cloud security products at the show is Santa Clara, Calif.-based Cenzic, which just unveiled a new self-service Web security platform: ClickToSecure. With this release, the company is opening its APIs to support integration with other vendors' products, including Citrix and Xybershield.
Security as a Service is also on the agenda at this year's RSA event. Companies such as Franklin, Tennessee-based Cybera will be extolling the virtues of cloud-based security services. Cybera will be exhibiting with security products provider McAfee, and promises live demos of the new Secure|Wave wireless intrusion detection service on the exhibit floor.
Another Software as a Service provider, Orange, Calif.-based M86 Security, is planning to unveil a cloud-based secure messaging service at the show. The service combines inbound and outbound content filtering, granular policy control, an anti-spam engine and behavioral malware analysis technology.
On the standards front, the members of the OASIS open standards consortium are planning to demo three security standards at the show: Identity Metasystem Interoperability (IMI), Key Management Interoperability Protocol (KMIP), and Cross-Enterprise Security and Privacy Authorization (XSPA). IMI enables the use of info cards to manage personal digital identities. KMIP provides a single protocol for communication between encryption systems and legacy enterprise appliances. XSPA is designed to enable the exchange of health care and privacy policies, consent directives and authorizations. The consortium's membership includes IBM, Microsoft, Sun/Oracle, CA, HP, Jericho Systems, Novell, SafeNet, the U.S. GSA, DOD and Department of Veterans Affairs.
Back for a second year is the RSA's Innovation Sandbox. These half-day, ask-the-experts, white-board sessions, held on Monday, included a discussion of social networks, the pros and cons of a corporate "Big Brother" mentality, and a session entitled "What the heck should the government do to improve security?"
Set for Tuesday, the annual cryptographers' panel is also back. Moderated by RSA Chief Scientist Ari Juels, the panel includes Whitfield Diffie, visiting professor from Royal Holloway College in London and Stanford visiting professor; Martin Hellman, EE professor at Stanford; Ronald Rivest, MIT computer science professor; Adi Shamir, computer science professor from Israel; and Brian Snow Former Technical Director, NSA IAD.
And event organizers have planned for some "special-guest" IT luminaries, including Apple co-founder Steve Wozniak and Craigslist founder Craig Newmark, among others.
This is the 19th RSA conference. The event is being held at San Francisco's Moscone Center and runs through Friday. Conference organizers said they expect a record crowd.
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Once a person owns shares in a company it is very difficult under law to force them to sell their shares to either the other shareholders or the company. The main way to do this is through a deemed offer clause in the contract.
Why force a sale?
The reasons why shareholders may want to force another shareholder to sell their shares mostly relate to the removal of shareholders, explains Abigail Reynolds, Corporate and Commercial Law Attorney at Reynolds Attorneys. This could be due to:
- That shareholder acting in bad faith (such as breaching a non-compete obligation) or causing injury to the reputation of the company;
- The shareholder dies, becomes disabled, or stops being employed by the company – because the company wants only shareholders that are actively involved in the company’s business to own the shares;
- When the control of an entity shareholder changes, such that the persons that originally controlled it, no longer does.
“The idea is that in a company in which there are only a few shareholders, it is important that the shareholders do not breach the various obligations they have agreed to as shareholders, that the identity of the shareholders remain the same (because the shareholders often chose to invest in a company based on the people who were originally invested in it), and that many of the shareholders are actively involved in growing the company’s business and are not passive investors,” says Reynolds.
The only way to force someone to sell their shares is by recording the terms for when this would arise in a contract and most common contract to record it in is a company’s memorandum of incorporation (MOI), or in a shareholders agreement. “The relevant clause is known as the deemed offer clause,” explains Reynolds, “because when a trigger event occurs, the shareholder to whom the event occurred is deemed to have offered his/its shares in the company for sale to the remaining shareholders.”
Some examples of common trigger events that result in a deemed offer include death; critical Illness or disability; termination of employment; administration issues; conviction of a criminal offence; fraud or dishonesty bringing a company into disrepute; gross misconduct; insolvency; breach of the MOI and/or the shareholders agreement; winding up; change of control of company; and change of beneficiaries of a trust.
There are a few ways that a deemed offer clause can be tailored to suit the requirements of the specific shareholders of the company:
- Penalty price: If the trigger event was one which involved bad behaviour by the shareholder, the price at which the other shareholders can buy that shareholder’s shares is discounted by a certain percentage from the fair market value of the shares (such as by 50%), or it could even be recorded to be just R1 per share.
- The trigger of a termination of employment by the company can apply to only some of the shareholders, or only apply if the shareholder was a ‘bad leaver’ (i.e. was fired), and not if he/she was a good leaver (i.e. retired or resigned).
- Nomination of company as purchaser: that a shareholder who receives the deemed offer can nominate the company itself to buy back the shares instead of that shareholder buying the shares.
It’s important to consider including the above in your company’s MOI or shareholders agreement to protect both the shareholders as well as the company itself.
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Incidences of identity theft are growing. Being hit particularly hard are the young—often the very young. Anytime a child is a victim, the crime is reprehensible. But what about when the crime is financial and the suspect is a parent?
According to the Atlanta Journal Constitution, more and more young adults are discovering they were the victims of identity theft, when they were children. And most often, the people accused of using their social security numbers and names are their parents.
Parents seem to be using their children’s information to gain credit where they otherwise couldn’t. Perhaps they put the utilities or apartment in their child’s name because they know they couldn’t personally pass a credit check. Then, when they get behind on payments, they are dooming their kids to a bad credit score and the same problem once they reach adulthood.
Despite some parents’ views that their children’s credit is their business and there’s to use as long as the kids are under their roof, the using of someone else’s identity to get credit is a criminal offense, no matter what the victim’s age is.
Typically we hear about the elderly being taken advantage of with fraud crimes. But, this story shows even the very young can be victimized.
Identity theft involves using the personal identification information of another person to gain credit, value, or money in their name. This could be taking out a credit card or applying for a loan. under Georgia law, identity theft is a serious offense.
For your first charge of identity theft, you are facing up to 10 years in prison and $100,000 in fines. If this is your second offense, your potential sentence jumps to 15 years. As you can see, this is considered a very serious criminal offense.
Contact us to discuss the details of your case involving any criminal charge in Georgia.
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This feature is called Reading Progress and it works by allowing students to record themselves reading a text or passage of text and gives teachers the ability to accurately grade, pronunciation errors and more. Microsoft is adding a new Reading Progress feature to Microsoft Teams, which is designed to help students improve their reading fluency.
Microsoft has been able to test its first alpha version of Reading Progress with more than 350 teachers since October and is now ready for deployment as a free add-on before the next school year. The technology is powered by Azure on the backend, allowing the teacher to adjust its sensitivity to measure students with speech or dyslexia issues.
This feature has great benefits for the teaching-learning process; if you think about reading fluently with classroom interaction, it currently becomes really difficult; because you can't be next to the students until the pandemic situation normalizes, Mike Tholfsen, product manager at Microsoft Education, says in an interview. "You may be able to set up Teams calls or Zoom calls, but the vast majority of teachers don't" this will serve as if it were a classroom.
Teachers will be able to look at a full dashboard showing words per minute and accuracy rate, and will have the option to jump to a specific word to hear a student speak it. Teachers can use, if desired, the automatic detection, or they can simply turn it off and watch a video of a student reading and then manually grade the student.
This speech technology will also handle different dialects and accents, although Microsoft is initially only launching it for a U.S. English audience and is currently testing it in the hope that it will soon be available in other languages.
Microsoft has been working on this feature for several years, after the team was able to hear from a teacher who made a large number of copies of spreadsheets for other teachers to record reading proficiency data and then merge it manually.
The company hopes that this technology can be used at other levels of education, to help with reading fluency such as special education, adult literacy and elsewhere
The vision is that using this technology will also be less stressful than having to sit in front of a teacher and read, which can be intimidating at any age. It should also allow teachers to spend less time teaching reading fluency.
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The Doll That Bommakka Made
Authors: Sheela Preuitt, Praba Ram
Illustrated by Debasmita Dasgupta
9789386652638 | Center Stapled | pp. 12 | 2018 | Pratham Books
This charming cumulative tale celebrates the tradition of hand-crafted dolls. Starting with a little ball of clay, we see the fine dancing doll grow before our eyes, inspired by a South Indian Thanjavur Thalai Atti Bommai.
Ships in 2-4 days
Out of stock
This charming cumulative tale celebrates the tradition of hand-crafted dolls. Starting with a little ball of clay, we see the fine dancing doll grow before our eyes, inspired by a South Indian Thanjavur Thalai Atti Bommai. The rhythmic descriptive words stacked in a delightful repetitive way invite the children to chant along.
Sheela Preuitt and Praba Ram
|Year of Publication:||
|Country of Origin:||
About the Contributors
Co-authors Praba Ram and Sheela Preuitt love telling tales about artisans and their handmade crafts. Blogging about children’s books at www.saffrontree.org, crafting with kids and promoting early-literacy programmes in their communities are some of their other passions.
Debasmita Dasgupta enjoys telling stories through visuals. Indian by birth, based in Singapore, Debasmita’s goal is to create art that can inspire you to sing the song of life with a positive note. She is also the founder of ‘My Father illustrations’, a series on inspiring father-daughter picture stories from across the globe.
This book will be shipped in 2 days. The time taken for you to receive the book after it is shipped will depend upon the mode you choose, while completing your purchase. The rates applicable for each mode are different.
You will be informed after the order is shipped.
Shipping costs depend on the mode chosen, the weight of the item, and the distance it will travel to reach its destination. Shipping costs will be charged depending on the weight of the entire purchase (if more than one item is purchased). The same shipping mode will apply to all products in such a case.
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Homewood Science Center is a nonprofit community science center founded in 2016 to serve Chicago’s culturally and economically diverse south suburbs. Our mission is to inspire scientific wonder, learning, and pursuit. We work with educators, STEM professionals, and partner organizations to increase STEM literacy and foster diversity, equity, and inclusion in STEM, so all area students can gain the skills and confidence they need to fully enjoy and contribute to the civic and commercial vibrancy of our region.
Homewood Science Center provides programs for children, families, schools, and afterschool centers; leads youth internships and volunteer opportunities; operates a community makerspace; maintains a demonstration native pollinator garden; presents films, exhibits, and speakers; teaches kids’ camps and classes; hosts robotics teams; and convenes regional STEM stakeholders for professional development and collaboration. The science center is “a great big community classroom I can rely on,” said one local parent.
Through our programs and events, Homewood Science Center is working to improve STEM literacy; close the STEM achievement gap for female, minority, and low-income students; and increase economic mobility. As a regional hub for STEM in south Cook County, Homewood Science Center provides area students the skills to thrive in the 21st century workforce, educators the tools to develop STEM-literate students, and business and industry the talent to innovate and grow.
Our programs include:
STEM Saturdays - Free programs and activities for families of young children, available weekly
PopUp SCIENCE @Home - Hands-on activities to spark children’s curiosity and exploration of STEM
Girls STEAM SUCCESS - Club for underserved female middle school students to meet diverse professional mentors and build 21st century job skills
Middle School Conservation Ecology Internship - Project-based internship to teach young people how to manage and preserve biodiversity and natural resources
Exploring Engineering - In-school field trips for pre-K and elementary students to develop interest, understanding, and self-efficacy in the engineering design process
Chicago Southland STEM Network - Platform for diverse stakeholders to collaborate on regional STEM education and workforce development
The RoundUp - Weekly email news digest with links to resources for families, educators, and STEM enthusiasts
Summer Camps & Classes - Engaging out-of-school STEM experiences for students in pre-K through 8th grade
Families of young learners explore STEM through hands-on activities, exhibits, creative play, and special presentations led by STEM enthusiasts and experts from leading institutions like the Forest Preserves of Cook County and University of Chicago. Children’s early experiences in STEM set the stage for future learning and economic mobility, and young learners whose families are engaged in their education earn higher grades and test scores, have better social skills, and show improved behavior.
PopUp SCIENCE @Home kits include materials and hands-on STEM activities supported by the Next Generation Science Standards, standards adopted by Illinois schools to prepare students for college and careers. Homewood Science Center distributes these kits in partnership with area schools, nonprofits, and municipal organizations. Elizabeth Reich, principal of Serena Hills Elementary School, a Title I, low-income school in Chicago Heights, said, “PopUp SCIENCE @Home gets kids interacting and creating and using those great 21st century skills that they’ll need to be employed later on.” Homewood Science Center also works with schools to develop PopUp SCIENCE classroom activities that support the schools’ science curricula.
Homewood Science Center’s Girls STEAM SUCCESS Club is a free afterschool program that empowers female middle school students to successfully set and achieve goals, build skills for high school, meet women in STEAM careers, and have fun with science. The program features eight club meetings at Homewood Science Center with healthy snacks, hands-on STEAM activities, and diverse mentors in STEAM; a family field trip; two summer film fest events; and a Back-to-School SUCCESS Soiree with end-of-year-awards. Research shows female mentors are a powerful force to help girls and young women maintain confidence in their skills, feel a sense of belonging, and stay committed to personal and professional goals in STEAM. “I liked that they helped me get to my life goals,” said one student participant.
Students who apply and are selected for this internship work with local ecology experts to plan and complete a youth-led conservation ecology project in the community, then present their work at a Homewood Science Center event. One student wrote of the group’s invasive species removal efforts at a local nature preserve, “I looked at the before and after pictures taken, and I was amazed at the difference we had all made, working together.”
On Homewood Science Center in-school field trips, pre-K and elementary students learn STEM vocabulary, are introduced to STEM principles, and experience the engineering design process first-hand, through STEM activities supported by the Next Generation Science Standards. “Kids need to be hands-on to understand. This helps them get enthused about learning,” said one teacher about the program.
The Chicago Southland STEM Network is a platform for parents, educators, nonprofits, business and industry leaders, and policymakers to work together to improve regional STEM education and workforce development. Homewood Science Center keeps this group informed about STEM opportunities via a weekly news digest and convenes the network twice yearly for professional development and networking. “I always learn something new,” wrote one attendee. “It’s a great way to find ideas and develop relationships,” wrote another. Relationships built through the Chicago Southland STEM Network are bringing fresh resources to STEM educators in the south suburbs. For example, Homewood Science Center partnered in hosting Northwestern University’s STEM Summit for K-12 educators in 2019, the first time in the event’s 10-year history to be held in south Cook County.
Homewood Science Center also works closely with the Jones Center, a charitable organization that offers programming for low-income youth in Chicago Heights, and Restoration Ministries, a nonprofit serving young people in Harvey. Julia Martin, Restoration Ministries director of youth programming, said, “For our kids, keeping science in their lives is crucial. The science center is the difference between that happening and not happening.”
Homewood Science Center's email news digest takes STEM to a higher level with five quick links to resources for families, educators, and STEM enthusiasts each week. The RoundUp keeps our community informed about what's happening in STEM and celebrates STEM achievement, locally and globally.
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