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PMID:24090 | Detection of a complex intermediate in the oxidation of ascorbic acid by the copper (II) ion. | A complex intermediate of the copper (II) ion with the ascorbate anion was detected by using a rapid scanning spectrophotometer with a stopped-flow apparatus. The intermediate was confirmed to be a copper (II) complex ion by electron paramagnetic resonance measurements. The dependence of the absorbance of the complex o... | Detection of a complex intermediate in the oxidation of ascorbic acid by the copper (II) ion. A complex intermediate of the copper (II) ion with the ascorbate anion was detected by using a rapid scanning spectrophotometer with a stopped-flow apparatus. The intermediate was confirmed to be a copper (II) complex ion by e... | [
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PMID:24092 | Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat. | Arachidonic acid-induced aggregation of rat platelets and the accompanying generation of thromboxane A2 activity were inhibited by aspirin, whereas 20 times higher doses of salicylic, gentisic and salicyluric acids were inactive. Salicylic acid administered to the rats before aspirin prevented the inhibition of the cyc... | Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat. Arachidonic acid-induced aggregation of rat platelets and the accompanying generation of thromboxane A2 activity were inhibited by aspirin, whereas 20 times higher doses of salicylic, gentisic and... | [
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PMID:24093 | Studies on the role of ACTH and of 5-HT in anxiety, using an animal model. | The effects of ACTH (5 & 7.5 microgram/100 g) were studied using a new animal model of anxiety. ACTH had an anxiogenic effect that was maximal during a 10 min test period starting 3 min after injection. The behavioural effects of ACTH were counteracted by chronic administration of chlordiazepoxide (5 mg kg-1 for 5 ... | Studies on the role of ACTH and of 5-HT in anxiety, using an animal model. The effects of ACTH (5 & 7.5 microgram/100 g) were studied using a new animal model of anxiety. ACTH had an anxiogenic effect that was maximal during a 10 min test period starting 3 min after injection. The behavioural effects of ACTH were c... | [
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PMID:24106 | Problems associated with analysis and interpretation of small molecule/macromolecule binding data. | In the analysis of binding data, arbitrary transformations such as the Scatchard plot, may give misleading estimates of the binding parameters. The statistically correct approach is to determine values of K and n by non-linear regression of the actual dependent variable against the actual independent variable. In the c... | Problems associated with analysis and interpretation of small molecule/macromolecule binding data. In the analysis of binding data, arbitrary transformations such as the Scatchard plot, may give misleading estimates of the binding parameters. The statistically correct approach is to determine values of K and n by non-l... | [
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PMID:24107 | The effect of drug concentration on the thermal (dark) degradation of promethazin hydrochloride in aqueous solution. | The thermal (dark) degradation of promethazine hydrochloride in aqueous solution presents a complex kinetic picture. The process is oxygen dependent and is modified by EDTA. In citrate buffer, pH 4.0, ionic strength 0.5M, containing 0.1% EDTA, the thermal degradation at 90 degrees can be fitted to first order rate plot... | The effect of drug concentration on the thermal (dark) degradation of promethazin hydrochloride in aqueous solution. The thermal (dark) degradation of promethazine hydrochloride in aqueous solution presents a complex kinetic picture. The process is oxygen dependent and is modified by EDTA. In citrate buffer, pH 4.0, io... | [
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PMID:24108 | The determination of salicylic acid and benzoic acid in pharmaceutical formulations by spectrofluorimetry. | Methods of extraction from pharmaceutical formulations and subsequent determination of benzoic acid and salicylic acid by spectrofluorimetry are described. The recovery of benzoic acid, in the presence of salicylic acid, was 99.3%, with a coefficient of variation of 1.04%, while the recovery of salicylic acid, in the p... | The determination of salicylic acid and benzoic acid in pharmaceutical formulations by spectrofluorimetry. Methods of extraction from pharmaceutical formulations and subsequent determination of benzoic acid and salicylic acid by spectrofluorimetry are described. The recovery of benzoic acid, in the presence of salicyli... | [
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PMID:24109 | Gastric erosions induced by analgesic drug mixtures in the rat. | Gastric erosions after oral administration of analgesics separately and in admixture have been examined in adult rats. After administration of acetylsalicylic acid (aspirin), phenacetin, paracetamol and caffeine as single drugs, gastric erosions were only observed with aspirin. The combination of aspirin with phenaceti... | Gastric erosions induced by analgesic drug mixtures in the rat. Gastric erosions after oral administration of analgesics separately and in admixture have been examined in adult rats. After administration of acetylsalicylic acid (aspirin), phenacetin, paracetamol and caffeine as single drugs, gastric erosions were only ... | [
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PMID:24110 | Effect of tolerance to morphine, ethanol and barbiturate on amphetamine circling in rats with a striatal dopamine lesion. | The (+)-amphetamine circling rate of rats with unilateral 6-OHDA lesions in the striatum was recorded. Morphine tablets were implanted subcutaneously for chronic treatment. In the morphine-dependent animal the circling rate to amphetamine given 4 days after morphine was first implanted was depressed but after withdrawa... | Effect of tolerance to morphine, ethanol and barbiturate on amphetamine circling in rats with a striatal dopamine lesion. The (+)-amphetamine circling rate of rats with unilateral 6-OHDA lesions in the striatum was recorded. Morphine tablets were implanted subcutaneously for chronic treatment. In the morphine-dependent... | [
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PMID:24111 | Effects of bromocriptine on adenylate cyclase and phosphodiesterase activities of rat striatum. | The activity of 2-bromo-alpha-ergokryptine (bromocriptine) (5 mg kg-1, i.p.) on adenylate cyclase and on phosphodiesterase (PDE-PDE II) of rat striatum, has been examined both in vitro and in vivo. In vitro and in vivo bromocriptine stimulated adenylate cyclase activity, but reduced the stimulating effect of dopamine o... | Effects of bromocriptine on adenylate cyclase and phosphodiesterase activities of rat striatum. The activity of 2-bromo-alpha-ergokryptine (bromocriptine) (5 mg kg-1, i.p.) on adenylate cyclase and on phosphodiesterase (PDE-PDE II) of rat striatum, has been examined both in vitro and in vivo. In vitro and in vivo bromo... | [
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PMID:24112 | A comparison of the binding constant (KD) of 125I-labelled 3-(4-iodophenoxy)-1-isopropylamino-propan-2-ol obtained on beta-adrenoceptors in guinea-pig myocardial membranes, with its dissociation constants (KB) obtained on guinea-pig isolated atria and trachea. | The dissociation constant of binding (KD) of 125I-labelled 3-(4-iodophenoxy)-1-isoproplyaminopropan-2-ol (IIP) to guinea-pig myocardial membrane preparations was 2.2 x 10-8M. In pharmacological experiments with the non-labelled material and 60 min contact time, IIP produced a parallel shift in the orciprenaline concent... | A comparison of the binding constant (KD) of 125I-labelled 3-(4-iodophenoxy)-1-isopropylamino-propan-2-ol obtained on beta-adrenoceptors in guinea-pig myocardial membranes, with its dissociation constants (KB) obtained on guinea-pig isolated atria and trachea. The dissociation constant of binding (KD) of 125I-labelled ... | [
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PMID:24114 | Inhibition of hydrochloric acid and pepsin secretion from gastric pouches by antral pouch acidification in sheep. | 1. Secretion of acid and pepsin from separated pouches of the body of the abomasum was studied in sheep during perfusion of antral pouches with acid solutions. 2. Resting secretion of acid and pepsin was reduced by acidification of antral pouches to pH 2.7 or less. 3. Increases in the secretion of HCl and pepsin normal... | Inhibition of hydrochloric acid and pepsin secretion from gastric pouches by antral pouch acidification in sheep. 1. Secretion of acid and pepsin from separated pouches of the body of the abomasum was studied in sheep during perfusion of antral pouches with acid solutions. 2. Resting secretion of acid and pepsin was re... | [
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PMID:24115 | Osmotic behaviour of human red blood cells: an interpretation in terms of negative intracellular fluid pressure. | 1. The observation that human red blood cells do not shrink in hypertonic media as much as expected for ideal osmometers has previously been explained in terms of either a marked increase in the osmotic coefficient of the cell contents or an increase in the chloride content of the cells.2. Changes in suspension pH and ... | Osmotic behaviour of human red blood cells: an interpretation in terms of negative intracellular fluid pressure. 1. The observation that human red blood cells do not shrink in hypertonic media as much as expected for ideal osmometers has previously been explained in terms of either a marked increase in the osmotic coef... | [
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PMID:24116 | Effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition. | 1. The effects of alpha- and beta-adrenoceptor agonists and antagonists on chemosensory discharges originating from carotid bodies in situ were studied in anaesthetized cats.2. Noradrenaline (NA) injections commonly resulted in increased frequency of carotid nerve chemosensory discharge, an effect ascribed to reduced b... | Effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition. 1. The effects of alpha- and beta-adrenoceptor agonists and antagonists on chemosensory discharges originating from carotid bodies in situ were studied in anaesthetized cats.2. Noradrenaline (NA) injections commonly resulte... | [
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PMID:24120 | Acid secretion and intracellular pH in isolated oxyntic cells. | This study demonstrates that isolated oxyntic cells are capable of secreting hydrochloric acid. Transitory peaks of medium acidification were observed when isolated oxyntic cells were stimulated with diffferent secretagogues. The duration of these peaks was of about 3 min and had a magnitude of about 0.5 muEquiv/hr mg ... | Acid secretion and intracellular pH in isolated oxyntic cells. This study demonstrates that isolated oxyntic cells are capable of secreting hydrochloric acid. Transitory peaks of medium acidification were observed when isolated oxyntic cells were stimulated with diffferent secretagogues. The duration of these peaks was... | [
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PMID:24121 | Transport of heterocyclic acids across rat small intestine in vitro. | A study has been made of the steady-state fluxes of barbituric acid, six of its substituted derivatives, and 5,5-dimethyloxazolidinedione (DMO) across the wall of rat jejunum in vitro. For each of the compounds tested the mucosal (M) to serosal (S) flux was significantly larger than the S to M flux. Both M to S and S t... | Transport of heterocyclic acids across rat small intestine in vitro. A study has been made of the steady-state fluxes of barbituric acid, six of its substituted derivatives, and 5,5-dimethyloxazolidinedione (DMO) across the wall of rat jejunum in vitro. For each of the compounds tested the mucosal (M) to serosal (S) fl... | [
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PMID:24124 | Deoxypyrimidine nucleoside metabolism in varicella-zoster virus-infected cells. | Noninfected and varicella-zoster virus (VZV)-infected human foreskin fibroblasts were examined for thymidine kinase activity. The specific activity of VZV-infected cell extracts was approximately 7.5-fold greater than that of mock-infected cells and 3-fold greater than that of actively growing cells. The pH optimum of ... | Deoxypyrimidine nucleoside metabolism in varicella-zoster virus-infected cells. Noninfected and varicella-zoster virus (VZV)-infected human foreskin fibroblasts were examined for thymidine kinase activity. The specific activity of VZV-infected cell extracts was approximately 7.5-fold greater than that of mock-infected ... | [
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PMID:24125 | Protein kinase from avian myeloblastosis virus. | A protein kinase associated with purified virions of avian myeloblastosis BAI strain A was partially purified by ion-exchange chromatography and gel filtration. The transfer of phosphate catalyzed by this enzyme required a divalent metal ion and ATP as phosphate donor. GTP could not be substituted for ATP, and the reac... | Protein kinase from avian myeloblastosis virus. A protein kinase associated with purified virions of avian myeloblastosis BAI strain A was partially purified by ion-exchange chromatography and gel filtration. The transfer of phosphate catalyzed by this enzyme required a divalent metal ion and ATP as phosphate donor. GT... | [
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PMID:24127 | Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis. | The activity of lysyl oxidase which catalyzes the initial step of cross-linking of collagen and elastin polypeptides was measured in blood vessels of the hypertensive rat. The enzyme activity was increased in the aorta and mesenteric artery when hypertension was induced in 8-week-old rats with administration of deoxyco... | Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis. The activity of lysyl oxidase which catalyzes the initial step of cross-linking of collagen and elastin polypeptides was measured in blood vessels of the hypertensive rat. The enzyme activit... | [
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PMID:24130 | Pathogenicity of a vaccine strain of vaccina virus in rabbits administered by intravenous route. | The pathogenicity of the Lister (Elstree) strain, a vaccinia virus, in rabbits after intravenous injection was studied by histopathological and immunofluorescent methods. Inoculation of 1 X 10(7) PFU (pock-forming unit) virus into weanling and young adult rabbits caused severe emaciation and high mortality within 2 wee... | Pathogenicity of a vaccine strain of vaccina virus in rabbits administered by intravenous route. The pathogenicity of the Lister (Elstree) strain, a vaccinia virus, in rabbits after intravenous injection was studied by histopathological and immunofluorescent methods. Inoculation of 1 X 10(7) PFU (pock-forming unit) vir... | [
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PMID:24132 | Correction of hyperkalemia by bicarbonate despite constant blood pH. | Patients having hyperkalemia often are given bicarbonate to raise blood pH and shift extracellular potassium into cells. Blood pH in many hyperkalemic patients, however, is compensated. To determine whether bicarbonate, independent of its pH action, affects plasma potassium, 14 hyperkalemic patients were treated with b... | Correction of hyperkalemia by bicarbonate despite constant blood pH. Patients having hyperkalemia often are given bicarbonate to raise blood pH and shift extracellular potassium into cells. Blood pH in many hyperkalemic patients, however, is compensated. To determine whether bicarbonate, independent of its pH action, a... | [
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PMID:24139 | Localization of some glycolipid glycosylating enzymes in the Golgi apparatus of rat kidney. | Cell fractions from rat kidney were isolated and studied for their ability to synthesize several possible intermediates in the biosynthesis of sulfatides and gangliosides. The enzymes studied include UDP-Gal:ceramide galactosyltransferase, UDP-Gal:glucosylceramide galactosyltransferase, UDP-Gal:galactosylceramide galac... | Localization of some glycolipid glycosylating enzymes in the Golgi apparatus of rat kidney. Cell fractions from rat kidney were isolated and studied for their ability to synthesize several possible intermediates in the biosynthesis of sulfatides and gangliosides. The enzymes studied include UDP-Gal:ceramide galactosylt... | [
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PMID:24143 | [Classical and modified intramedullary nailing in osteomyelitis pseudoarthroses]. | 13 cases of osteomyelitic pseudarthroses following injury were treated by the authors, by means of intramedullary nailing. 5 of these patients already cured are introduced in detail in the article. Intramedullary nailing in the classic manner and its modification, using bolts as well, were performed alike. The authors ... | [Classical and modified intramedullary nailing in osteomyelitis pseudoarthroses]. 13 cases of osteomyelitic pseudarthroses following injury were treated by the authors, by means of intramedullary nailing. 5 of these patients already cured are introduced in detail in the article. Intramedullary nailing in the classic ma... | [
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PMID:24144 | [Experience in the treatment of peripheral vascular injuries]. | The authors report the results of the treatment of injuries to the peripheral blood vessels that were observed at the Semmelweis OTE in 16 years. As a result of primary operative treatment the peripheral pulse returned to the injured limb in 10 cases. A quick diagnosis and instant reconstructive surgery is absolutely n... | [Experience in the treatment of peripheral vascular injuries]. The authors report the results of the treatment of injuries to the peripheral blood vessels that were observed at the Semmelweis OTE in 16 years. As a result of primary operative treatment the peripheral pulse returned to the injured limb in 10 cases. A qui... | [
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PMID:24145 | [Congenital knee luxation]. | The authors discuss the frequency, etiology, symptoms and classification as well as treatment of congenital dislocation of the knee. 8 own cases are reported in the article. The authors suggest that congenital dislocation of the may be well influenced by non-operative methods. Etappe redressement by means of plaster do... | [Congenital knee luxation]. The authors discuss the frequency, etiology, symptoms and classification as well as treatment of congenital dislocation of the knee. 8 own cases are reported in the article. The authors suggest that congenital dislocation of the may be well influenced by non-operative methods. Etappe redress... | [
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PMID:24146 | [Evaluation of operations on discoid meniscus]. | A short survey of literature is given in the article. 1480 meniscectomies were performed at the Orthopedic Clinic of Semmelweis Medical University in the interval between 1952--75; 29 of these cases were carried out for discoid menisci. Symptoms are introduced and results of operative treatment are evaluated. The autho... | [Evaluation of operations on discoid meniscus]. A short survey of literature is given in the article. 1480 meniscectomies were performed at the Orthopedic Clinic of Semmelweis Medical University in the interval between 1952--75; 29 of these cases were carried out for discoid menisci. Symptoms are introduced and results... | [
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PMID:24147 | [Treatment of hand injuries on the principle of "delayed emergency"]. | A certain number of drunk patients who suffered hand injury were not prone to operation on the day of admission, as usual, for different reasons (behaviour of the patient etc.). These patients were treated on the delayed urgency principle, that Iselin worked out. Results in the 266 cases were surprisingly good. There w... | [Treatment of hand injuries on the principle of "delayed emergency"]. A certain number of drunk patients who suffered hand injury were not prone to operation on the day of admission, as usual, for different reasons (behaviour of the patient etc.). These patients were treated on the delayed urgency principle, that Iseli... | [
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PMID:24148 | [Spontaneous rupture of the extensor pollicis longus tendon]. | A rare case of "spontaneous" rupture of the extensor pollicis longus tendon with primary chronic polyarthritis in the background is reported in this paper. In this case a transposition of the extensor indicis proprius was carried out, with the modification by J. Böhler and Manninger. This method gives a very good funct... | [Spontaneous rupture of the extensor pollicis longus tendon]. A rare case of "spontaneous" rupture of the extensor pollicis longus tendon with primary chronic polyarthritis in the background is reported in this paper. In this case a transposition of the extensor indicis proprius was carried out, with the modification b... | [
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PMID:24149 | [2 cases of congenital humero-radial synostosis]. | Two cases of a rare congenital deformity, humeroradial aplasia are reported in the article. In the first case the deformity was unilateral, in the second case a bilateral aplasia was associated to hip dislocation and aplasia of the os ischii. | [2 cases of congenital humero-radial synostosis]. Two cases of a rare congenital deformity, humeroradial aplasia are reported in the article. In the first case the deformity was unilateral, in the second case a bilateral aplasia was associated to hip dislocation and aplasia of the os ischii. | [
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PMID:24150 | [Double gunshot head injury with lesion of the upper cervical vertebrae in a case of attempted suicide]. | The authors hold their case reported in this paper interesting for the following reasons: in several minutes two shots were fired by intention of suicide. Two entrance openings were found that had the characteristics of shots fired within close range, but no exit openings were to be seen. Considering the entrance openi... | [Double gunshot head injury with lesion of the upper cervical vertebrae in a case of attempted suicide]. The authors hold their case reported in this paper interesting for the following reasons: in several minutes two shots were fired by intention of suicide. Two entrance openings were found that had the characteristic... | [
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PMID:24151 | [Surgical correction of a case of congenital proximal radio-ulnar synostosis]. | The author reports a case of S.R.U.P.C. that was relieved by a Nigrisoli operation. There is a good function after two years. The author thought it worth publishing this cae because of its rarity: in the last twenty years only one article appeared on this problem in the Rumanian medical literature that reported 5 cases... | [Surgical correction of a case of congenital proximal radio-ulnar synostosis]. The author reports a case of S.R.U.P.C. that was relieved by a Nigrisoli operation. There is a good function after two years. The author thought it worth publishing this cae because of its rarity: in the last twenty years only one article ap... | [
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PMID:24152 | [A case of open carpo-metacarpal dislocation complicated by dislocation of the trapezoid bone]. | A case of open carpo-metacarpal dislocation complicated by dislocation of the os trapesium is reported in this paper. The patient's wrist healed with good functional results, despite a partial mistake in diagnosis. The authors draw attention to the fact, that X-ray films taken at admission must be analysed carefully an... | [A case of open carpo-metacarpal dislocation complicated by dislocation of the trapezoid bone]. A case of open carpo-metacarpal dislocation complicated by dislocation of the os trapesium is reported in this paper. The patient's wrist healed with good functional results, despite a partial mistake in diagnosis. The autho... | [
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PMID:24153 | [Bullet embolism of the median cerebral artery]. | A shot injury to the middle cerebral artery caused occlusion to the vessel by thrombosis and emboly of the missile. The projectil had been removed, but a thrombus formed in the a. cerebri media as a postoperative complication or by progression of a thrombosis in the internal carotid artery and after 19 days the patient... | [Bullet embolism of the median cerebral artery]. A shot injury to the middle cerebral artery caused occlusion to the vessel by thrombosis and emboly of the missile. The projectil had been removed, but a thrombus formed in the a. cerebri media as a postoperative complication or by progression of a thrombosis in the inte... | [
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PMID:24155 | H2-receptor antagonists in perspective. | Cimetidine, like its predecessors burinamide and metiamide, has been shown in vitro to be a specific competitive histamine H2-receptor antagonist. In vivo, it is a potent inhibitor of histamine-stimulated gastric acid secretion in animals and man after both intravenous and oral administration. Doses sufficient to inhib... | H2-receptor antagonists in perspective. Cimetidine, like its predecessors burinamide and metiamide, has been shown in vitro to be a specific competitive histamine H2-receptor antagonist. In vivo, it is a potent inhibitor of histamine-stimulated gastric acid secretion in animals and man after both intravenous and oral a... | [
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PMID:24156 | Neural and endocrine development after chronic tryptophan deficiency in rats: I. Brain monoamine and pituitary responses. | Caloric restriction and tryptophan deficient diets have been shown to delay aging in the immature laboratory rat. Studies of monoamine levels in the brain of developing female rats fed on these diets show changes in serotonin but not norepinephrine or dopamine levels: in tryptophan-restricted rats serotonin levels were... | Neural and endocrine development after chronic tryptophan deficiency in rats: I. Brain monoamine and pituitary responses. Caloric restriction and tryptophan deficient diets have been shown to delay aging in the immature laboratory rat. Studies of monoamine levels in the brain of developing female rats fed on these diet... | [
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PMID:24161 | Reactions between peroxidizing lipids and histidyl residue analogues: enhancement of lipid oxidation and browning by 4-methylimidazole. | As a part of our study on the interactions between peroxidizing lipids and the histidyl imidazole side-chain in simple, low-moisture model systems, 4-methylimidazole (4MI) was reacted with methyl linoleate (ML). This analogue was chosen to avoid interference from other functional groups in histidine (free base) or in p... | Reactions between peroxidizing lipids and histidyl residue analogues: enhancement of lipid oxidation and browning by 4-methylimidazole. As a part of our study on the interactions between peroxidizing lipids and the histidyl imidazole side-chain in simple, low-moisture model systems, 4-methylimidazole (4MI) was reacted ... | [
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PMID:24162 | Patterns of the use of benzodiazepines in Australia. | In six suburban areas of Sydney, chosen to provide a socioeconomic cross-section of the city, complete records of dispensing of benzodiazepine were collected over a four-week period. These drugs constituted 3.7% of all dispensing, female patients outnumbered males by 2.3:1, and 98% of patients were over 20 years of age... | Patterns of the use of benzodiazepines in Australia. In six suburban areas of Sydney, chosen to provide a socioeconomic cross-section of the city, complete records of dispensing of benzodiazepine were collected over a four-week period. These drugs constituted 3.7% of all dispensing, female patients outnumbered males by... | [
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PMID:24163 | The prevention of prematurity. | The prevention of prematurity requires identification of the patients most likely to go into labour prematurely and early recognition of threatened premature labour. There are unfortunately few clinical signs to help identify these patients, but certain features in the history are helpful. As soon as premature labour i... | The prevention of prematurity. The prevention of prematurity requires identification of the patients most likely to go into labour prematurely and early recognition of threatened premature labour. There are unfortunately few clinical signs to help identify these patients, but certain features in the history are helpful... | [
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PMID:24171 | Kinetic studies on 3-hydroxykynureninase from rat liver. | 3-Hydroxykynureninase was purified from rat liver. The Michaelis constants for L-kynurenine and L-3-hydroxykynurenine were determined to be 2.33 X 10(-4)M and 6.85 X 10(-5)M, respectively, at pH 8.41 and 37 degrees. With L-kynurenine as substrate, the enzyme was competitively inhibited by L-alanine, 3-hydroxyanthranili... | Kinetic studies on 3-hydroxykynureninase from rat liver. 3-Hydroxykynureninase was purified from rat liver. The Michaelis constants for L-kynurenine and L-3-hydroxykynurenine were determined to be 2.33 X 10(-4)M and 6.85 X 10(-5)M, respectively, at pH 8.41 and 37 degrees. With L-kynurenine as substrate, the enzyme was ... | [
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PMID:24179 | Structural evidence for gene duplication in the evolution of the acid proteases. | X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular twofold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for evolution by gene duplication, divergence and gene fusion is presented. | Structural evidence for gene duplication in the evolution of the acid proteases. X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular twofold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for ev... | [
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PMID:24188 | Disequilibrium pH and bicarbonate reabsorption: relevance to the pathogenesis of distal renal tubular acidosis. | An augmented renal capacity to reabsorb bicarbonate (RHCO3) has been noted in patients with distal renal tubular acidosis (dRTA), and construed as evidence that the basic defect in dRTA is abnormal distal tubular permeability. According to this interpretation, the absence of a disequilibrium pH due to a back-leak of H2... | Disequilibrium pH and bicarbonate reabsorption: relevance to the pathogenesis of distal renal tubular acidosis. An augmented renal capacity to reabsorb bicarbonate (RHCO3) has been noted in patients with distal renal tubular acidosis (dRTA), and construed as evidence that the basic defect in dRTA is abnormal distal tub... | [
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PMID:24189 | [Hemodynamic and electrocardiographic effects caused by intravenous infusion of a tricyclic antidepressive agent dibenzepin]. | The cardiovascular (blood pressure, heart rate, central venous pressure) and ECG changes caused by dibenzepine-infusion (720 mg/day for 48 hours) have been assessed. Mean blood pressure and heart rate did not show significant changes. In some patients, however, distinct changes in both variables were observed. Central ... | [Hemodynamic and electrocardiographic effects caused by intravenous infusion of a tricyclic antidepressive agent dibenzepin]. The cardiovascular (blood pressure, heart rate, central venous pressure) and ECG changes caused by dibenzepine-infusion (720 mg/day for 48 hours) have been assessed. Mean blood pressure and hear... | [
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PMID:24190 | [Metabolic alkalosis. III. Spontaneous and experimental compensation mechanisms in plasma and erythrocytes]. | Plasma and red cell acid-base balance were studied in 13 patients with metabolic alkalosis and 14 healthy subjects following the infusion of bicarbonate. Differences between the plasma and red cell patterns suggested that application of the results of plasma determinations to the body as a whole could be the cause of s... | [Metabolic alkalosis. III. Spontaneous and experimental compensation mechanisms in plasma and erythrocytes]. Plasma and red cell acid-base balance were studied in 13 patients with metabolic alkalosis and 14 healthy subjects following the infusion of bicarbonate. Differences between the plasma and red cell patterns sugg... | [
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PMID:24192 | The use of relaxation and desensitisation techniques in eliminating a sleep problem. | This study describes the treatment of a 16-year-old youth unable to sleep, failing to respond to sleeping pills, who on a programme of relaxation and desensitisation in six weeks was able to control his sleeping patterns. On followup four months, six months and twelve months later this ability had been maintained. | The use of relaxation and desensitisation techniques in eliminating a sleep problem. This study describes the treatment of a 16-year-old youth unable to sleep, failing to respond to sleeping pills, who on a programme of relaxation and desensitisation in six weeks was able to control his sleeping patterns. On followup f... | [
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PMID:24193 | Prazosin in hypertension. Part I. Clinical experience in 100 patients. | This paper reports the findings of an open evaluation of 100 patients treated with prazosin. When prazosin was added to existing hypotensive regimens in 50 patients whose blood pressure was poorly controlled, 36 (72 percent) became normotensive. Treatment was initiated with prazosin in a further 50 patients. Satisfacto... | Prazosin in hypertension. Part I. Clinical experience in 100 patients. This paper reports the findings of an open evaluation of 100 patients treated with prazosin. When prazosin was added to existing hypotensive regimens in 50 patients whose blood pressure was poorly controlled, 36 (72 percent) became normotensive. Tre... | [
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PMID:24194 | Effects of lorazepam on hyperactivity in ratarded children. | Seven mentally-retarded children, diagnosed as hyperactive, participated in a double-blind trial of the drug lorazepam (Ativan). Statistical analysis of the behavioural records showed that hyperactivity was typically greater during lorazepam than during placebo periods. The degree of hyperactivity was not systematicall... | Effects of lorazepam on hyperactivity in ratarded children. Seven mentally-retarded children, diagnosed as hyperactive, participated in a double-blind trial of the drug lorazepam (Ativan). Statistical analysis of the behavioural records showed that hyperactivity was typically greater during lorazepam than during placeb... | [
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PMID:24195 | Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation. | In in vitro studies it was found that, in the presence of added NADPH, the human placenta metabolizes progesterone to 20alpha-hydroxy-4-pregnen-3-one at increasing rates as pregnancy advances. A fivefold increase in 20alpha-hydroxysteroid oxidoreductase activity is observed in term placentas compared with the enzymic a... | Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation. In in vitro studies it was found that, in the presence of added NADPH, the human placenta metabolizes progesterone to 20alpha-hydroxy-4-pregnen-3-one at increasing rates as pregnancy advances. A fivefold increas... | [
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PMID:24196 | [Development of hematopietic and lymphoid tissues in conjoint bone marrow and thymus transplants]. | The model of heterotopic transplantation of the mixture of bone marrow and thymus fragments was used to study the interaction of hemopoietic and lymphoid tissues under their direct contact. The bone marrow and thymus fragments of adult mice F1 (CBAXXC57BL) were transplanted separately or in the mixture under the kidney... | [Development of hematopietic and lymphoid tissues in conjoint bone marrow and thymus transplants]. The model of heterotopic transplantation of the mixture of bone marrow and thymus fragments was used to study the interaction of hemopoietic and lymphoid tissues under their direct contact. The bone marrow and thymus frag... | [
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PMID:24201 | Stimulation of the activity of Schistosoma mansoni miracidia by snail-conditioned water. | A dark-ground photographic technique was used to analyse the reactions of Schistosoma mansoni miracidia to homogeneous solutions of snail-conditioned water (SCW). The most significant effect of this water was to increase miracidial turning. This effect was maintained under both acid and alkaline conditions, after passa... | Stimulation of the activity of Schistosoma mansoni miracidia by snail-conditioned water. A dark-ground photographic technique was used to analyse the reactions of Schistosoma mansoni miracidia to homogeneous solutions of snail-conditioned water (SCW). The most significant effect of this water was to increase miracidial... | [
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PMID:24208 | Poisoning in children under age 5: identification and treatment. | A rational approach to management of poisoning in young children requires assessment of what, when, and how much drug was ingested. Emesis, if indicated, is followed by general supportive measures, enhanced removal of absorbed poison, and antidote therapy. | Poisoning in children under age 5: identification and treatment. A rational approach to management of poisoning in young children requires assessment of what, when, and how much drug was ingested. Emesis, if indicated, is followed by general supportive measures, enhanced removal of absorbed poison, and antidote therapy... | [
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PMID:24209 | The biochemistry of the basal ganglia and Parkinson's disease. | The metabolic pathways for five transmitters in the basal ganglia are briefly described; the results of determinations of their concentrations, of their rate-limiting enzymes and of their degradation products are summarized. The changes found in Parkinson's disease are described. While dopamine synthesis in the basal g... | The biochemistry of the basal ganglia and Parkinson's disease. The metabolic pathways for five transmitters in the basal ganglia are briefly described; the results of determinations of their concentrations, of their rate-limiting enzymes and of their degradation products are summarized. The changes found in Parkinson's... | [
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PMID:24210 | Urticaria--current concepts. | The mechanisms, clinical features and management of the various forms of urticaria are discussed. The importance of histamine receptors, complement and the kinin cascade are reviewed. | Urticaria--current concepts. The mechanisms, clinical features and management of the various forms of urticaria are discussed. The importance of histamine receptors, complement and the kinin cascade are reviewed. | [
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PMID:24212 | Evidence for acceleration of the rate of elongation of tyrosine aminotransferase nascent chains by dibutyryl cyclic AMP. | Analogs of cyclic AMP elevate the synthesis of tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5) in cultured hepatoma cells and rat liver at a post-transcriptional level but have no discernible effect on total soluble protein synthesis. In order to determine whether cyclic AMP exerts it... | Evidence for acceleration of the rate of elongation of tyrosine aminotransferase nascent chains by dibutyryl cyclic AMP. Analogs of cyclic AMP elevate the synthesis of tyrosine aminotransferase (L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5) in cultured hepatoma cells and rat liver at a post-transcriptional le... | [
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PMID:24213 | Agonist-induced increase in apparent beta-adrenergic receptor size. | The properties of digitonin-solubilized beta-adrenergic receptors from frog erythrocyte membranes were studied by gel exclusion chromatography on AcA 34 Ultragel. beta-Adrenergic receptor binding activity in these membranes can be identified by both an agonist ligand, [(3)H]hydroxybenzylisoproterenol, and the antagonis... | Agonist-induced increase in apparent beta-adrenergic receptor size. The properties of digitonin-solubilized beta-adrenergic receptors from frog erythrocyte membranes were studied by gel exclusion chromatography on AcA 34 Ultragel. beta-Adrenergic receptor binding activity in these membranes can be identified by both an... | [
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PMID:24214 | Myristic acid stimulation of bacterial bioluminescence in "aldehyde" mutants. | The involvement of long chain aldehyde in bacterial luminescence was known both from its being required for light emission in the in vitro reaction with pure luciferase and from its ability to stimulate luminescence in vivo in a certain class of dark "aldehyde" mutants. We have found that the luminescence of some (but ... | Myristic acid stimulation of bacterial bioluminescence in "aldehyde" mutants. The involvement of long chain aldehyde in bacterial luminescence was known both from its being required for light emission in the in vitro reaction with pure luciferase and from its ability to stimulate luminescence in vivo in a certain class... | [
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PMID:24215 | Self-association of hemoglobin betaSH chains is linked to oxygenation. | Self-association of unliganded beta(SH) chains into tetramers (4 beta(1) [unk] beta(4)) is experimentally found to be energetically less favorable (DeltaG(0) = -19.05 +/- 0.30 kcal) than the corresponding oligomerization of fully oxygenated chains (4 beta(1)X [unk] beta(4)X(4); DeltaG(0) = -22.45 +/- 0.35 kcal). Hence ... | Self-association of hemoglobin betaSH chains is linked to oxygenation. Self-association of unliganded beta(SH) chains into tetramers (4 beta(1) [unk] beta(4)) is experimentally found to be energetically less favorable (DeltaG(0) = -19.05 +/- 0.30 kcal) than the corresponding oligomerization of fully oxygenated chains (... | [
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PMID:24216 | Characterization of the residual adenosine deaminating activity in the spleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency. | A number of infants with an autosomal recessive form of combined immunodeficiency disease also lack adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) activity in their erythrocytes. Other tissues from these infants contain only a few percent of the adenosine-deaminating activity present in corresponding normal... | Characterization of the residual adenosine deaminating activity in the spleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency. A number of infants with an autosomal recessive form of combined immunodeficiency disease also lack adenosine deaminase (adenosine aminohydrolase; EC 3.5.... | [
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PMID:24217 | Proliferative capacity of murine hematopoietic stem cells. | The present study demonstrates a decrease in self-renewal capacity with serial transfer of murine hematopoietic stem cells. Production of differentiated cell progeny is maintained longer than stem cell self-renewal. In normal animals the capacity for self-renewal is not decreased with increasing donor age. The stem cel... | Proliferative capacity of murine hematopoietic stem cells. The present study demonstrates a decrease in self-renewal capacity with serial transfer of murine hematopoietic stem cells. Production of differentiated cell progeny is maintained longer than stem cell self-renewal. In normal animals the capacity for self-renew... | [
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PMID:24218 | Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction. | Transmitter release at the Drosophila larval neuromuscular junction may be increased by previous activity of the nerve. This facilitation phenomenon involves at least two processes, one short-term and other long-term. These are shown to based on different mechanisms because (i) a mutant was found that had abnormal long... | Genetic dissection of short-term and long-term facilitation at the Drosophila neuromuscular junction. Transmitter release at the Drosophila larval neuromuscular junction may be increased by previous activity of the nerve. This facilitation phenomenon involves at least two processes, one short-term and other long-term. ... | [
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PMID:24225 | Effect of antipsychotic and other classes of drugs on spontaneous locomotor activity and neurotoxicity in mice. | Quantitative estimates were made of the effects of several classes of drugs on spontaneous activity and neurotoxicity in mice. Clinically effective antipsychotic agents had a more selective action on spontaneous activity than other classes of drugs with the exception of clonidine and a related compound. | Effect of antipsychotic and other classes of drugs on spontaneous locomotor activity and neurotoxicity in mice. Quantitative estimates were made of the effects of several classes of drugs on spontaneous activity and neurotoxicity in mice. Clinically effective antipsychotic agents had a more selective action on spontane... | [
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PMID:24234 | Granulomatous ileocolitis (Crohn's disease). | In a clinical survey, the symptoms, associated diseases, and local and metabolic complications of Crohn's disease are discussed. Medical treatment (with SASP, corticosteroids, and immunosuppressives), as well as treatment for malnutrition, is of special importance. | Granulomatous ileocolitis (Crohn's disease). In a clinical survey, the symptoms, associated diseases, and local and metabolic complications of Crohn's disease are discussed. Medical treatment (with SASP, corticosteroids, and immunosuppressives), as well as treatment for malnutrition, is of special importance. | [
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PMID:24235 | Prostaglandin synthesis in human placenta and fetal membranes. | The conversion of exogenous arachidonic acid into prostaglandins was studied in human placenta and fetal membrane microsomes. Only one prostaglandin was formed, prostaglandin E2 (PGE2), in fetal membrane microsomes. In placental microsomes PGE2 was further transformed into 15 keto-PGE2. Cofactor requirements and some c... | Prostaglandin synthesis in human placenta and fetal membranes. The conversion of exogenous arachidonic acid into prostaglandins was studied in human placenta and fetal membrane microsomes. Only one prostaglandin was formed, prostaglandin E2 (PGE2), in fetal membrane microsomes. In placental microsomes PGE2 was further ... | [
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PMID:24241 | Tissue and blood gamma-glutamyl transferase distribution in the pig. | Gamma-glutamyl transferase distribution was studied in 10 pigs with an average weight of 100 kg. It was shown that kidney had the highest concentration of the enzyme, followed by pancreas, spleen and liver. Blood activities measured in plasma and sera from 54 animals were very similar, ie, 35+/-21 iu/litre for plasma a... | Tissue and blood gamma-glutamyl transferase distribution in the pig. Gamma-glutamyl transferase distribution was studied in 10 pigs with an average weight of 100 kg. It was shown that kidney had the highest concentration of the enzyme, followed by pancreas, spleen and liver. Blood activities measured in plasma and sera... | [
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PMID:24242 | An investigation into the viability of broth cultures of the T1 strain of Mycoplasma mycoides sub-species mycoides. | The T1 broth vaccine against contagious bovine pleuropneumonia can only be stored for four weeks at +4 degrees C because after that time the titre of Mycoplasma mycoides sub-species mycoides falls below the minimal vaccinating dose. An investigation into the death of these organisms during the stationary growth phase w... | An investigation into the viability of broth cultures of the T1 strain of Mycoplasma mycoides sub-species mycoides. The T1 broth vaccine against contagious bovine pleuropneumonia can only be stored for four weeks at +4 degrees C because after that time the titre of Mycoplasma mycoides sub-species mycoides falls below t... | [
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PMID:24243 | Activities of ketone body utilising enzymes in tissues of fed and fasted sheep. | The activities of 3-hydroxybutyrate dehydrogenase, 3-ketoacid CoA-transferase and acetyl-CoA acetyltransferase have been measured in the kidney, heart and brain of fed and four-day fasted ewes. The results indicate tha there is a decrease in the capacity of these organs to catabolise ketone bodies in fasting ketosis. | Activities of ketone body utilising enzymes in tissues of fed and fasted sheep. The activities of 3-hydroxybutyrate dehydrogenase, 3-ketoacid CoA-transferase and acetyl-CoA acetyltransferase have been measured in the kidney, heart and brain of fed and four-day fasted ewes. The results indicate tha there is a decrease i... | [
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PMID:24244 | Clinical and metabolic consequences to cattle of rumen overdosing with di-ureido iso-butane (DUIB). | Di-ureido iso-butane (DUIB) was overdosed on three occasions to two year-old bullocks, under experimental conditions. Six g/kg live weight of DUIB was mixed manually into the rumen contents formed by a predominantly hay diet (10 kg) with added concentrates (2 kg). Marked clinical signs were observed for 72 h before rec... | Clinical and metabolic consequences to cattle of rumen overdosing with di-ureido iso-butane (DUIB). Di-ureido iso-butane (DUIB) was overdosed on three occasions to two year-old bullocks, under experimental conditions. Six g/kg live weight of DUIB was mixed manually into the rumen contents formed by a predominantly hay ... | [
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PMID:24261 | A new method for determination of microsomal haem oxygenase (EC 1.14.99.3) based on quantitation of carbon monoxide formation. | Microsomal haem oxygenase (MHO) catalyses the main pathway for haem degradation. Hitherto bilirubin formation rate (BFR) has been used for determination of MHO activity. In the present study a method is described where MHO activity is assessed from the rate of carbon monoxide formation (VCO) in tissue homogenates with ... | A new method for determination of microsomal haem oxygenase (EC 1.14.99.3) based on quantitation of carbon monoxide formation. Microsomal haem oxygenase (MHO) catalyses the main pathway for haem degradation. Hitherto bilirubin formation rate (BFR) has been used for determination of MHO activity. In the present study a ... | [
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PMID:24262 | Dissolution and uptake of cadmium from dental gold solder alloy implants. | Pure metallic cadmium was irradiated by means of thermal neutrons. The irradiated cadmium (115Cd) was placed in bags of gold foil and the bags were implanted subcutaneously in the neck region of mice. Two and 3d respectively after implantation the mice were killed, the bags removed and the animals subjected to whole-bo... | Dissolution and uptake of cadmium from dental gold solder alloy implants. Pure metallic cadmium was irradiated by means of thermal neutrons. The irradiated cadmium (115Cd) was placed in bags of gold foil and the bags were implanted subcutaneously in the neck region of mice. Two and 3d respectively after implantation th... | [
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PMID:24263 | Composition of the alkaline component of human gastric juice: effect of swallowed saliva and duodeno-gastric reflux. | Five patients (four with vitiligo and one with pernicious anaemia) were subjected to the histamine infusion test; there were achlorhydric while the remaining two secreted quite small amounts of acid. [Na+],[Cl-)and[alkali]were determined in the alkaline gastric juice samples (pH greater than 7.0). In order to assess th... | Composition of the alkaline component of human gastric juice: effect of swallowed saliva and duodeno-gastric reflux. Five patients (four with vitiligo and one with pernicious anaemia) were subjected to the histamine infusion test; there were achlorhydric while the remaining two secreted quite small amounts of acid. [Na... | [
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PMID:24264 | A sensitive method for specific quantitation of secretory IgA. | A method to quantitate specifically secretory IgA (SIgA) has been developed using the enzyme-linked immunosorbent assay. The IgA in the test sample was adsorbed to anti-alpha antibodies attached to plastic tubes via a cost of IgA myeloma protein. The reacted SIgA was determined using anti-secretory component antiserum ... | A sensitive method for specific quantitation of secretory IgA. A method to quantitate specifically secretory IgA (SIgA) has been developed using the enzyme-linked immunosorbent assay. The IgA in the test sample was adsorbed to anti-alpha antibodies attached to plastic tubes via a cost of IgA myeloma protein. The reacte... | [
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PMID:24265 | Detection of hepatitis B antigen in circulating immune complexes in acute and chronic hepatitis. | By using polyethylene glycol precipitation at low concentration (PEG test) and the radiolabeled C1q binding test, immune complexes were detected sera from acute (23/28) and chronic (28/32) hepatitis patients, hemodialyzed patients with chronic hepatitis B surface (HBs) antigenemia (7/19), and asymptomatic HBs antigen c... | Detection of hepatitis B antigen in circulating immune complexes in acute and chronic hepatitis. By using polyethylene glycol precipitation at low concentration (PEG test) and the radiolabeled C1q binding test, immune complexes were detected sera from acute (23/28) and chronic (28/32) hepatitis patients, hemodialyzed p... | [
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PMID:24271 | [Pipoxizin, a new bronchodilator]. | Pipoxizin is a new bronchodilator with the chemical name chlorhydrate-4-diphenyl-methylene-1-(2-/2-(2-hydroxy-ethoxy)-ethoxy/-ethyl/-ethyl)-piperidine. This substance exhibits powerful antihistaminic and antiserotonin properties but no parasympathetic or beta-adrenergic properties. The effects of Pipoxizin have been co... | [Pipoxizin, a new bronchodilator]. Pipoxizin is a new bronchodilator with the chemical name chlorhydrate-4-diphenyl-methylene-1-(2-/2-(2-hydroxy-ethoxy)-ethoxy/-ethyl/-ethyl)-piperidine. This substance exhibits powerful antihistaminic and antiserotonin properties but no parasympathetic or beta-adrenergic properties. Th... | [
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PMID:24273 | Nature and nurture in development of the autonomic neuron. | Arguments are presented for the hypothesis that during an early stage of development the cells which become principal neurons of the autonomic nervous system possess information regarding the positions they will occupy within the body. A second stage of development, during which a decision is made regarding which neuro... | Nature and nurture in development of the autonomic neuron. Arguments are presented for the hypothesis that during an early stage of development the cells which become principal neurons of the autonomic nervous system possess information regarding the positions they will occupy within the body. A second stage of develop... | [
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PMID:24275 | Experimental Brugia timori and Wuchereria bancrofti infections in certain species of mosquitoes. | Laboratory reared Aedes aegypti (black eye and Jakarta strains), Aedes togoi, (Taiwan), Aedes albopictus, (Jakarta), wild caught Anopheles barbirostris, (Java) and Mansonia uniformis, (Jakarta) were fed on a carrier with mixed infection of Brugia timori and Wuchereria bancrofti. B. timori and W. bancrofti were able to ... | Experimental Brugia timori and Wuchereria bancrofti infections in certain species of mosquitoes. Laboratory reared Aedes aegypti (black eye and Jakarta strains), Aedes togoi, (Taiwan), Aedes albopictus, (Jakarta), wild caught Anopheles barbirostris, (Java) and Mansonia uniformis, (Jakarta) were fed on a carrier with mi... | [
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PMID:24272 | Genetic analysis of the nitrogen fixation system in Klebsiella pneumoniae. | Fine structure mapping of nif mutations of Klebsiella pneumoniae was accomplished by means of Pl-transductional crosses and the plasmid R144 drd mediated conjugations. The physical distance between nif mutations based on the percentage of co-transduction with hisD of the nif mutations was estimated. The maximal distanc... | Genetic analysis of the nitrogen fixation system in Klebsiella pneumoniae. Fine structure mapping of nif mutations of Klebsiella pneumoniae was accomplished by means of Pl-transductional crosses and the plasmid R144 drd mediated conjugations. The physical distance between nif mutations based on the percentage of co-tra... | [
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PMID:24280 | Interactions of gastric blood flow, barrier breaker, and hydrogen ion back diffusion during ulcer formation in the rat. | A rat gastric chamber preparation was used to determine the interrelations between H+ back diffusion, mucosal blood flow, the area of mucosa treated with bile salts and ulcer formation. The rate of H+ back diffusion was found to be dependent on both mucosal blood flow and the area of mucosa exposed to bile salts. It is... | Interactions of gastric blood flow, barrier breaker, and hydrogen ion back diffusion during ulcer formation in the rat. A rat gastric chamber preparation was used to determine the interrelations between H+ back diffusion, mucosal blood flow, the area of mucosa treated with bile salts and ulcer formation. The rate of H+... | [
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PMID:24281 | Lateral ventral (spigelian) hernias in infants and children. | Lateral ventral hernias are found in the spigelian fascia lateral to the junction of the arcuate and semilunar lines and below the level of the umbilicus. Three cases are reported in infants and children. Diagnosis depends on finding an unusual mass on the anterior abdominal wall and palpation of the rim of the hernia ... | Lateral ventral (spigelian) hernias in infants and children. Lateral ventral hernias are found in the spigelian fascia lateral to the junction of the arcuate and semilunar lines and below the level of the umbilicus. Three cases are reported in infants and children. Diagnosis depends on finding an unusual mass on the an... | [
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PMID:24284 | The efficiency of diamphenethide in controlling natural infestations of Fasciola hepatica in lambs. | The activity of diamphenethide against natural infestations of Fasciola hepatica in fattening lambs was assessed on a farm with a noted history of fascioliasis. The main experimental groups, two treated and one control, grazed known contaminated pastures for a twelve week period after which they were removed to fluke-f... | The efficiency of diamphenethide in controlling natural infestations of Fasciola hepatica in lambs. The activity of diamphenethide against natural infestations of Fasciola hepatica in fattening lambs was assessed on a farm with a noted history of fascioliasis. The main experimental groups, two treated and one control, ... | [
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PMID:24288 | Arbovirus isolations from mosquitoes: Kano Plain, Kenya. | Arbovirus isolation attempts on 324,486 mosquitoes captured over a four-year period on the Kano Plain, Kenya, yielded 15 isolates including Pongola (six strains), Ilesha (three strains), Germiston (two strains), Sindbis (one strain), Barur (one strain) and two viruses which could not be characterized. Mansonia uniformi... | Arbovirus isolations from mosquitoes: Kano Plain, Kenya. Arbovirus isolation attempts on 324,486 mosquitoes captured over a four-year period on the Kano Plain, Kenya, yielded 15 isolates including Pongola (six strains), Ilesha (three strains), Germiston (two strains), Sindbis (one strain), Barur (one strain) and two vi... | [
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PMID:24294 | Congenital testicular lymphangiectasis. | Testicular lymphangiectasis are described for the first time in a patient with bilateral inguinal cryptorchidism. A great number of irregular lymphatic channels was observed within the parenchyma and the tunica vasculosa in both testes. Large and numerous anastomosis between the lymphatic vessels of these two areas cou... | Congenital testicular lymphangiectasis. Testicular lymphangiectasis are described for the first time in a patient with bilateral inguinal cryptorchidism. A great number of irregular lymphatic channels was observed within the parenchyma and the tunica vasculosa in both testes. Large and numerous anastomosis between the ... | [
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PMID:24291 | Preservation of human granulocytes. III. Liquid preservation studied by electronic sizing. | Human granulocytes were isolated from blood either by counterflow centrifugation in a Beckman JE-6 rotor or by sedimentation of the red blood cells with dextran and centrifugation of the granulocyte-rich plasma. The stability of the granulocytes was assessed during storage in the liquid state by measurements of granulo... | Preservation of human granulocytes. III. Liquid preservation studied by electronic sizing. Human granulocytes were isolated from blood either by counterflow centrifugation in a Beckman JE-6 rotor or by sedimentation of the red blood cells with dextran and centrifugation of the granulocyte-rich plasma. The stability of ... | [
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PMID:24295 | Carcinoid tumour of the thymus. A case report including discussion of the morphological diagnosis and the cell of origin. | This report concerns a 49 year old asymptomatic male who had a mediastinal mass demonstrated on routine radiography. A large encapsulated tumour composed of small regular cells arranged in clumps and acini with fine vascular stroma was removed. The differential diagnosis on routine H&E section included parathyroid ... | Carcinoid tumour of the thymus. A case report including discussion of the morphological diagnosis and the cell of origin. This report concerns a 49 year old asymptomatic male who had a mediastinal mass demonstrated on routine radiography. A large encapsulated tumour composed of small regular cells arranged in clumps an... | [
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PMID:24292 | The effect of agitation of stored human blood on microaggregate formation. | Microaggregates (MA) composed of platelets and white blood cells form during the storage of human blood. These particles are believed to be a cause of pulmonary insufficiency in patients receiving massive blood transfusions. The present controlled study determined the effect of constant gentle agitation of CPD-anticoag... | The effect of agitation of stored human blood on microaggregate formation. Microaggregates (MA) composed of platelets and white blood cells form during the storage of human blood. These particles are believed to be a cause of pulmonary insufficiency in patients receiving massive blood transfusions. The present controll... | [
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PMID:24293 | [Some properties of Mg 2+, Ca 2+-AtPase of brain microsomal fractions and synaptic plasma membranes in the solubilized state]. | Digitonin-solubilized Mg2+, Ca2+-ATPases of the brain microsomal fraction and synaptic plasma membranes are activated against a background of 6.0 mM Mg2+ by 0.001 and 0.03 mM of the added Ca2+ and manifest maximum activity at temperatures or 40-45 and 35-42 degrees C, respectively. The enzymes of the initial membrane p... | [Some properties of Mg 2+, Ca 2+-AtPase of brain microsomal fractions and synaptic plasma membranes in the solubilized state]. Digitonin-solubilized Mg2+, Ca2+-ATPases of the brain microsomal fraction and synaptic plasma membranes are activated against a background of 6.0 mM Mg2+ by 0.001 and 0.03 mM of the added Ca2+ ... | [
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PMID:24306 | The disposition of phentermine and its N-oxidized metabolic products in the rabbit. | 1. When phentermine was injected intraperitoneally to rabbits, 77% of the dose was excreted in the urine within 2 days; N-oxidized metabolic products accounted for 62% dose. Major excretion products were N-hydroxyphentermine (28% dose), conjugated N-hydroxyphentermine (32% dose) and unchanged phentermine (16% dose). 2.... | The disposition of phentermine and its N-oxidized metabolic products in the rabbit. 1. When phentermine was injected intraperitoneally to rabbits, 77% of the dose was excreted in the urine within 2 days; N-oxidized metabolic products accounted for 62% dose. Major excretion products were N-hydroxyphentermine (28% dose),... | [
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PMID:24308 | [Neonatal depression in the absence of azidose (author's transl)]. | In addition to those children delivered by cesarean, a noticeable number of premature infants show a neonatal depression without intrauterine or neonatal acidosis. The reasons for this are only partially known. Anesthesia, on the one hand, and the underdeveloped brain, on the other hand, are held responsible. The progn... | [Neonatal depression in the absence of azidose (author's transl)]. In addition to those children delivered by cesarean, a noticeable number of premature infants show a neonatal depression without intrauterine or neonatal acidosis. The reasons for this are only partially known. Anesthesia, on the one hand, and the under... | [
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PMID:24309 | Studies on glutamic-oxalacetic (GOT) and glutamic-pyruvic (GPT) transaminases of swine kidney worm Stephanurus dentatus (Diesing, 1839). I. Assay and general properties. | Biochemical studies on the two transaminases GOT and GPT of swine kidney worm Stephanurus dentatus have been made. GOT has been found much more active than GPT. Enzyme activities are based on the formation of oxaloacetate (GOT) or pyruvate (GPT) from aspartic acid and alanine respectively with oxoglutarate. A linear re... | Studies on glutamic-oxalacetic (GOT) and glutamic-pyruvic (GPT) transaminases of swine kidney worm Stephanurus dentatus (Diesing, 1839). I. Assay and general properties. Biochemical studies on the two transaminases GOT and GPT of swine kidney worm Stephanurus dentatus have been made. GOT has been found much more active... | [
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PMID:24311 | [The significance of serum gamma-glutamyl transpeptidase determination in the differentiation of icterus of various etiologies]. | In a group of 29 patients with mechanical icterus and a control group of 38 patients (acute, chronic hepatitis and hyperbilirubinemia) there have been followed up alkaline phosphatase, leucinaminopeptidase and gammaglutamil transpeptidase activities aiming to evaluate the value of gamma GT in differentiation of icterus... | [The significance of serum gamma-glutamyl transpeptidase determination in the differentiation of icterus of various etiologies]. In a group of 29 patients with mechanical icterus and a control group of 38 patients (acute, chronic hepatitis and hyperbilirubinemia) there have been followed up alkaline phosphatase, leucin... | [
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PMID:24312 | The stability properties of golden beet and red beet pigments: influence of pH, temperature, and some stabilizers. | Golden beet (Beta vulgaris var. lutea) color was found to contain 8 components, of which the most important seemed to be vulgaxanthin-I and -II. Purified vulgazanthin -I solutions are easily degraded at high temperatures. The stability is, however, strongly dependent on pH: the stability is best at pH values between 5 ... | The stability properties of golden beet and red beet pigments: influence of pH, temperature, and some stabilizers. Golden beet (Beta vulgaris var. lutea) color was found to contain 8 components, of which the most important seemed to be vulgaxanthin-I and -II. Purified vulgazanthin -I solutions are easily degraded at hi... | [
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PMID:24313 | [Dialysis technic for regulation of the internal milieu in acute poisoning]. | In 72 patients with acute poisoning (15 patients without unconsciousness with 80% of acute renal and hepatic failure, and 57 patients with unconciousness with 10.5% of acute renal and hepatic failure) the significance of the continuous prolonged haemodialysis lasting on an average 12 hours, respectively 18 hours, with ... | [Dialysis technic for regulation of the internal milieu in acute poisoning]. In 72 patients with acute poisoning (15 patients without unconsciousness with 80% of acute renal and hepatic failure, and 57 patients with unconciousness with 10.5% of acute renal and hepatic failure) the significance of the continuous prolong... | [
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PMID:24314 | [Current status of treatment of parasellar meningiomas]. | For 302 patients presenting the respective indication in the years 1968 to 1972 the operation lethality amounted to 24.8%. Then the microtechnique including the operation microscope were introduced. Out of 47 cases of tuberculum sellae meningiomas one patient died; out of 42 patients suffering from median meningiomas o... | [Current status of treatment of parasellar meningiomas]. For 302 patients presenting the respective indication in the years 1968 to 1972 the operation lethality amounted to 24.8%. Then the microtechnique including the operation microscope were introduced. Out of 47 cases of tuberculum sellae meningiomas one patient die... | [
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PMID:24315 | [Genital disorders that influence fertility and potency. Screening methods]. | It is recommended to introduce screening for fertility and potency determination to disclose genital disturbances the correction of which must be done in childhood or early age. Cryptorchism, undescended testicles or their hypoplasia, hypogonadism, hypogenitalism, hypospadias and finally varicocele are easily detected ... | [Genital disorders that influence fertility and potency. Screening methods]. It is recommended to introduce screening for fertility and potency determination to disclose genital disturbances the correction of which must be done in childhood or early age. Cryptorchism, undescended testicles or their hypoplasia, hypogona... | [
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PMID:24317 | Changes in serum TSH level after intraventricular injection of various neuromediators in rats. | The influence of various neuromediators on pituitary TSH secretion in rats has been investigated. Noradrenaline 50 microgram/rat, dopamine 50 microgram/rat, serotonine-creatinine-sulphate 100 micogram/rat, gamma-aminobutyric acid 100 microgram/rat, pilocarpine 1 mg/rat, histamine 100 microgram/rat were administered int... | Changes in serum TSH level after intraventricular injection of various neuromediators in rats. The influence of various neuromediators on pituitary TSH secretion in rats has been investigated. Noradrenaline 50 microgram/rat, dopamine 50 microgram/rat, serotonine-creatinine-sulphate 100 micogram/rat, gamma-aminobutyric ... | [
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PMID:24318 | ATP-induced release of vasopressin associated with phosphorylation of isolated bovine neurohypophyseal secretory granule membranes. | Secretory granules isolated from ox neurohypophyses released their content of vasopressin in the presence of ATP and Mg2+. A half maximal ATP concentration of 0.25 mM was found. Ca2+ was not necessary for the effect. High concentrations of ADP, AMP and ITP were shown to mimic the effect of ATP. Utilizing this effect of... | ATP-induced release of vasopressin associated with phosphorylation of isolated bovine neurohypophyseal secretory granule membranes. Secretory granules isolated from ox neurohypophyses released their content of vasopressin in the presence of ATP and Mg2+. A half maximal ATP concentration of 0.25 mM was found. Ca2+ was n... | [
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PMID:24319 | Evaluation of the usefulness of serum gamma-glutamyl transpeptidase levels in the management of haematological neoplasia. | The levels of serum gamma-glutamyl transpeptidase (GGT) and, when appropriate, alkaline phosphatase (AP) and 5'-nucleotidase (NTD) have been measured as a routine in 276 patients with malignant haematological diseases during a 26-month trial period. GGT levels add no prognostic information to the routine haematological... | Evaluation of the usefulness of serum gamma-glutamyl transpeptidase levels in the management of haematological neoplasia. The levels of serum gamma-glutamyl transpeptidase (GGT) and, when appropriate, alkaline phosphatase (AP) and 5'-nucleotidase (NTD) have been measured as a routine in 276 patients with malignant haem... | [
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PMID:24320 | "False positive" acidified serum test in a preleukemic dyserythropoiesis. | In a case of preleukemic dyserythropoiesis, in vitro red cell lysis tests showed a positive acidified serum test whose characteristics are described. The positive acidified serum test occurred in 10 normal sera, in 1 serum with complete deficiency of the fourth component of complement and in 1 serum with complete defic... | "False positive" acidified serum test in a preleukemic dyserythropoiesis. In a case of preleukemic dyserythropoiesis, in vitro red cell lysis tests showed a positive acidified serum test whose characteristics are described. The positive acidified serum test occurred in 10 normal sera, in 1 serum with complete deficienc... | [
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PMID:24323 | Pharmacokinetics of 2-pivaloylindan-1,3-dione in dogs. | The pharmacokinetics of 2-pivaloylindan-1,3-dione (Pival) after administration of a single dose was investigated in dogs. The plasma concentration graph can be described by a one compartment open model. The drug is fairly well adsorbed (67%) and the excretion is extremely slow with a half-life of nearly five days. Thes... | Pharmacokinetics of 2-pivaloylindan-1,3-dione in dogs. The pharmacokinetics of 2-pivaloylindan-1,3-dione (Pival) after administration of a single dose was investigated in dogs. The plasma concentration graph can be described by a one compartment open model. The drug is fairly well adsorbed (67%) and the excretion is ex... | [
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PMID:24324 | Minoxidil in severe hypertension. | Minoxidil has been administered to 16 patients with severe hypertension and renal failure. In every patient the indication for minoxidil treatment was resistance to conventional drugs. The final dose of minoxidil was 2.5--30 mg (average 20) and it was combined with a beta-blocking agent and a diuretic (or dialysis). Th... | Minoxidil in severe hypertension. Minoxidil has been administered to 16 patients with severe hypertension and renal failure. In every patient the indication for minoxidil treatment was resistance to conventional drugs. The final dose of minoxidil was 2.5--30 mg (average 20) and it was combined with a beta-blocking agen... | [
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PMID:24327 | Histamine H2-receptor antagonists. | Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contr... | Histamine H2-receptor antagonists. Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to al... | [
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PMID:24329 | Biodistribution of salicylates: a clue to the understanding of some effects and side effects. | According to our concept that biodistribution of salicylates (SA) might be an important factor of their mode of action the distribution of sodiumsalicylate (NaSA) and acetylsalicylic acid (ASA) was investigated in vivo and in vitro. It was shown that particular high concentrations of both compounds were found in vivo i... | Biodistribution of salicylates: a clue to the understanding of some effects and side effects. According to our concept that biodistribution of salicylates (SA) might be an important factor of their mode of action the distribution of sodiumsalicylate (NaSA) and acetylsalicylic acid (ASA) was investigated in vivo and in ... | [
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PMID:24330 | Renal excretion of fluid, electrolytes and hydrogen ions before and during diamox administration in healthy Nigerians. | Twenty-four urine specimens of eleven healthy Nigerians taken during the cool rainy season, were examined before and during diamox (acetazolamide) administration. Mean control volume-output was 1.4 litres containing 109.5 mEq Na+, 46.6 mEq K+ and 120 mEq Cl- ions. Total renal acid excretion was 36.82 partitioned as 14.... | Renal excretion of fluid, electrolytes and hydrogen ions before and during diamox administration in healthy Nigerians. Twenty-four urine specimens of eleven healthy Nigerians taken during the cool rainy season, were examined before and during diamox (acetazolamide) administration. Mean control volume-output was 1.4 lit... | [
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