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PMID:30756 | Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin. | Two enzymes have been partially purified from extracts of Escherchia coli B which together catalyze the conversion of the product of the action of GTP cyclohydrolase II, 2,5-diamino-6-oxy-4-(5'-phosphoribosylamine)pyrimidine, to 5-amino-2,6-dioxy-4-(5'-phosphoribitylamine)pyrimidine. These two compounds are currently t... | Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin. Two enzymes have been partially purified from extracts of Escherchia coli B which together catalyze the conversion of the product of the action of GTP cyclohydrolase II, 2,5-diamino-6-oxy-4-(5'-phosphoribosylamine)pyrimi... | [
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PMID:30757 | Regulation of uridylic acid biosynthesis in the cyanobacterium Anabaena variabilis. | The pathway of uridylic acid biosynthesis established by Leiberman, Kornberg, and Simms has been shown to be operative in the filamentous cyanobacterium Anabaena variabilis. The only enzyme of uridylic acid biosynthesis found to be lacking in two uracil-requiring strains of A. variabilis was aspartate transcarbamylase,... | Regulation of uridylic acid biosynthesis in the cyanobacterium Anabaena variabilis. The pathway of uridylic acid biosynthesis established by Leiberman, Kornberg, and Simms has been shown to be operative in the filamentous cyanobacterium Anabaena variabilis. The only enzyme of uridylic acid biosynthesis found to be lack... | [
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PMID:30758 | Hydrolysis of phosphatidylethanolamine and phosphatidylglycerol by outer membrane phospholipase A from Acinetobacter sp. HO1-N. | An outer membrane phospholipase A active against phosphatidylglycerol and phosphatidylethanolamine was characterized from Acinetobacter sp. HO1-N. | Hydrolysis of phosphatidylethanolamine and phosphatidylglycerol by outer membrane phospholipase A from Acinetobacter sp. HO1-N. An outer membrane phospholipase A active against phosphatidylglycerol and phosphatidylethanolamine was characterized from Acinetobacter sp. HO1-N. | [
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PMID:30759 | Managing tardive dyskinesia. | Tardive dyskinesia, a delayed side effect of neuroleptic drugs, requires early recognition and a systematic treatment plan. An outline is presented which offers guidelines for management strategies and drug treatments, along with a summary of recent developments. | Managing tardive dyskinesia. Tardive dyskinesia, a delayed side effect of neuroleptic drugs, requires early recognition and a systematic treatment plan. An outline is presented which offers guidelines for management strategies and drug treatments, along with a summary of recent developments. | [
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PMID:30760 | Use of saliva lithium determinations for monitoring lithium therapy. | During acute and chronic administrations of lithium, 25 patients were studied to determine the effect of other psychotropic drugs on the plasma-saliva lithium concentration correlations. Changes, even discontinuation, in either tricyclic antidepressants or neuroleptics did not affect the plasma-saliva ratio which had a... | Use of saliva lithium determinations for monitoring lithium therapy. During acute and chronic administrations of lithium, 25 patients were studied to determine the effect of other psychotropic drugs on the plasma-saliva lithium concentration correlations. Changes, even discontinuation, in either tricyclic antidepressan... | [
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PMID:30761 | Comparative metabolism of lorazepam in man and four animal species. | The metabolic disposition of lorazepam (Wy-4036) in man, dog, cat, rat and miniature swine is compared. Except in the cat, absorption of lorazepam is rapid in these species. Absorption in humans is nearly complete. Lorazepam glucuronide is the major metabolite in all species except the rat in which a dihydrodiol deriva... | Comparative metabolism of lorazepam in man and four animal species. The metabolic disposition of lorazepam (Wy-4036) in man, dog, cat, rat and miniature swine is compared. Except in the cat, absorption of lorazepam is rapid in these species. Absorption in humans is nearly complete. Lorazepam glucuronide is the major me... | [
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PMID:30762 | Clinical pharmacokinetics of lorazepam: a review. | The clinical pharmacokinetics of lorazepam, a 3-hydroxy, 1,4-benzodiazepine, indicate that it is rapidly and readily absorbed, reaching peak concentrations in the blood proportional to the dose approximately 2 hours after oral administration. Blood levels decline thereafter, with an elimination half-life of about 12 hr... | Clinical pharmacokinetics of lorazepam: a review. The clinical pharmacokinetics of lorazepam, a 3-hydroxy, 1,4-benzodiazepine, indicate that it is rapidly and readily absorbed, reaching peak concentrations in the blood proportional to the dose approximately 2 hours after oral administration. Blood levels decline therea... | [
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PMID:30763 | Clinical assessment of the safety and efficacy of lorazepam, a new benzodiazepine derivative, in the treatment of anxiety. | In a four-week double-blind study of 68 adult outpatients, lorazepam a new benzodiazepine, administered at an average total daily dosage level of 3.1 mg on a b.i.d. regimen, was clearly superior to placebo in the treatment of neurotic anxiety and its related symptoms. The lorazepam-treated group showed significantly gr... | Clinical assessment of the safety and efficacy of lorazepam, a new benzodiazepine derivative, in the treatment of anxiety. In a four-week double-blind study of 68 adult outpatients, lorazepam a new benzodiazepine, administered at an average total daily dosage level of 3.1 mg on a b.i.d. regimen, was clearly superior to... | [
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PMID:30764 | Pharmacology of lorazepam. | Lorazepam reduced conflict behavior in rats and monkeys, inhibited pentylenetetrazol- and electroshock-induced convulsions, suppressed footshock-induced fighting behavior, and prevented morphine-induced stimulation in mice at lower doses than other benzodiazepines tested. This behavioral profile suggests that lorazepam... | Pharmacology of lorazepam. Lorazepam reduced conflict behavior in rats and monkeys, inhibited pentylenetetrazol- and electroshock-induced convulsions, suppressed footshock-induced fighting behavior, and prevented morphine-induced stimulation in mice at lower doses than other benzodiazepines tested. This behavioral prof... | [
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PMID:30765 | Studies with oral lorazepam in anxiety neurosis associated with depressive symptomatology. | Twelve studies were undertaken under a common four-week protocol to investigate the efficacy of lorazepam compared with placebo in reducing the severity of moderate to severe anxiety in 264 patients also having significant depressive symptomatology. Analysis of the results indicated that lorazepam gave generally better... | Studies with oral lorazepam in anxiety neurosis associated with depressive symptomatology. Twelve studies were undertaken under a common four-week protocol to investigate the efficacy of lorazepam compared with placebo in reducing the severity of moderate to severe anxiety in 264 patients also having significant depres... | [
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PMID:30766 | Antianxiety effects of lorazepam in patients with cardiovascular symptomatology. | Lorazepam was administered to 38 patients with moderate to severe anxiety associated with cardiovascular symptomatology. A comparable group of patients on placebo (35) served as controls in this 4-week study. Average dosage was 3 mg/day given as 2 mg in the evening and 1 mg in the morning. The Global response, Hamilton... | Antianxiety effects of lorazepam in patients with cardiovascular symptomatology. Lorazepam was administered to 38 patients with moderate to severe anxiety associated with cardiovascular symptomatology. A comparable group of patients on placebo (35) served as controls in this 4-week study. Average dosage was 3 mg/day gi... | [
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PMID:30767 | The effect of lorazepam on hypertension-associated anxiety: a double-blind study. | Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks. The patients were assessed by 7 cardiologists under double-blind conditions and the results pooled. Symptoms of anxiety were quantified... | The effect of lorazepam on hypertension-associated anxiety: a double-blind study. Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks. The patients were assessed by 7 cardiologists under d... | [
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PMID:30768 | A clinical assessment of lorazepam in the treatment of anxiety associated with gastrointestinal symptomatology. | The effectiveness of lorazepam was assessed under double-blind conditions in 70 ambulant patients suffering from anxiety associated with gastrointestinal symptomatology. In this 4-week study, the usual daily dose of lorazepam, 3.0 mg given in a b.i.d. regimen, produced a greater decrease in symptoms associated with anx... | A clinical assessment of lorazepam in the treatment of anxiety associated with gastrointestinal symptomatology. The effectiveness of lorazepam was assessed under double-blind conditions in 70 ambulant patients suffering from anxiety associated with gastrointestinal symptomatology. In this 4-week study, the usual daily ... | [
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PMID:30769 | Lorazepam in anxiety associated with chronic enteritis and ulcerative colitis. | Using a common protocol, 9 gastroenterologists assessed the comparative antianxiety efficacy of lorazepam and placebo under double-blind conditions in 48 patients with moderate to severe anxiety associated with chronic enteritis and ulcerative colitis. The initial dose of lorazepam was 3 mg per day given b.i.d., 2 mg h... | Lorazepam in anxiety associated with chronic enteritis and ulcerative colitis. Using a common protocol, 9 gastroenterologists assessed the comparative antianxiety efficacy of lorazepam and placebo under double-blind conditions in 48 patients with moderate to severe anxiety associated with chronic enteritis and ulcerati... | [
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PMID:30771 | Reversible conversion from Ca(2)+-ATPase activity to Mg(2)+- and Mn(2)+-ATPase activities of coupling factor purified from acetone powder of Rhodospirillum rubrum chromatophores. | It is known that the coupling factor purified from the acetone powder of chromatophores from Rhodospirillum rubrum shows ATPase activity in the presence of Ca(2)+, but not in the presence of Mg(2)+ or Mn(2)+. The present study deals with conditions, under which the Ca(2)+-ATPase activity is reversibly converted into Mg... | Reversible conversion from Ca(2)+-ATPase activity to Mg(2)+- and Mn(2)+-ATPase activities of coupling factor purified from acetone powder of Rhodospirillum rubrum chromatophores. It is known that the coupling factor purified from the acetone powder of chromatophores from Rhodospirillum rubrum shows ATPase activity in t... | [
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PMID:30772 | Nerve growth factor-mediated induction of tyrosine hydroxylase in rat superior cervical ganglia in vitro. | Exposure of rat sympathetic ganglia to 3 microgram/ml of 2.5 S nerve growth factor (NGF) resulted in a 100% increase in tyrosine hydroxylase activity within 48 h. Pulselabeling of proteins with [3H]leucine, followed by immunoprecipitation with antibodies to tyrosine hydorxylase and isolation of the precipitated enzyme ... | Nerve growth factor-mediated induction of tyrosine hydroxylase in rat superior cervical ganglia in vitro. Exposure of rat sympathetic ganglia to 3 microgram/ml of 2.5 S nerve growth factor (NGF) resulted in a 100% increase in tyrosine hydroxylase activity within 48 h. Pulselabeling of proteins with [3H]leucine, followe... | [
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PMID:30773 | Partial reactions of aminoacyl-tRNA synthetases as functions of pH. | The effect of pH on the properties of the partial reactions of arginyl-tRNA synthetase of E. coli has been investigated. V max of pyrophosphorolysis of arginyl adenylate has a pH optimum at pH 6.1, whereas V max of the transfer of arginine to tRNA has a pH optimum of 8.2. These values correlate with the pH optima of th... | Partial reactions of aminoacyl-tRNA synthetases as functions of pH. The effect of pH on the properties of the partial reactions of arginyl-tRNA synthetase of E. coli has been investigated. V max of pyrophosphorolysis of arginyl adenylate has a pH optimum at pH 6.1, whereas V max of the transfer of arginine to tRNA has ... | [
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PMID:30774 | Regulation of rat liver acetyl-CoA carboxylase. Stimulation of phosphorylation and subsequent inactivation of liver acetyl-CoA carboxylase by cyclic 3':5'-monophosphate and effect on the structure of the enzyme. | The effects of citrate and cyclic AMP on the rate and degree of phosphorylation and inactivation of rat liver acetyl-CoA carboxylase were examined. High citrate concentrations (10 to 20 mM), which are generally used to stabilize and activate the enzyme, inhibit phosphorylation and inactivation of carboxylase. At lower ... | Regulation of rat liver acetyl-CoA carboxylase. Stimulation of phosphorylation and subsequent inactivation of liver acetyl-CoA carboxylase by cyclic 3':5'-monophosphate and effect on the structure of the enzyme. The effects of citrate and cyclic AMP on the rate and degree of phosphorylation and inactivation of rat live... | [
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PMID:30775 | Effect of epinephrine on acetyl-CoA carboxylase in rat epididymal fat tissue. | If acetyl-CoA carboxylase in epididymal fat tissue is subject to control by convalent modification as in the case of the liver enzyme, catalytically different forms of carboxylase should exist, independent of polymerization. By treating epididymal fat tissue in culture with epinephrine, we have demonstrated catalytical... | Effect of epinephrine on acetyl-CoA carboxylase in rat epididymal fat tissue. If acetyl-CoA carboxylase in epididymal fat tissue is subject to control by convalent modification as in the case of the liver enzyme, catalytically different forms of carboxylase should exist, independent of polymerization. By treating epidi... | [
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PMID:30777 | The unfolding of the cytochromes c in methanol and acid. | The cytochromes c are a family of hemoproteins that share a number of structural features: a thioether linkage between the protein and the heme, histidine and methionine as the fifth and sixth iron ligands, and a tertiary structure known as the "cytochrome fold." These proteins follow a common mechanism of equilibrium ... | The unfolding of the cytochromes c in methanol and acid. The cytochromes c are a family of hemoproteins that share a number of structural features: a thioether linkage between the protein and the heme, histidine and methionine as the fifth and sixth iron ligands, and a tertiary structure known as the "cytochrome fold."... | [
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PMID:30778 | Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation. | Purification of soluble guanylate cyclase activity from rat liver resulted in loss of enzyme responsiveness to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), nitroprusside, nitrite, and NO. Responses were restored by addition of heat-treated hepatic supernatant fraction, implying a requirement for heat-stable soluble fac... | Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide, and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation. Purification of soluble guanylate cyclase activity from rat liver resulted in loss ... | [
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PMID:30780 | The sensitivity of hemoglobin oxygen affinity to diphosphoglycerate and the characteristic pH of methemoglobin. | The sensitivity of the oxygen affinity of a hemoglobin to 2,3-diphosphoglyceric acid concentration has been defined as the change in log1/2O2 (deltalogp1/2O2) which results from saturating the hemoglobin with 2,3-diphosphoglyceric acid. The sensitivity varies from one hemoglobin species to another and is linearly rated... | The sensitivity of hemoglobin oxygen affinity to diphosphoglycerate and the characteristic pH of methemoglobin. The sensitivity of the oxygen affinity of a hemoglobin to 2,3-diphosphoglyceric acid concentration has been defined as the change in log1/2O2 (deltalogp1/2O2) which results from saturating the hemoglobin with... | [
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PMID:30782 | Platelet derived growth factor(s) for a hormone-responsive rat mammary tumor cell line. | Mammary tumor cell growth factor(s) has been identified in extracts of platelets from both male and female rats, as well as in extracts prepared from pooled outdated human platelets. When assayed by the growth promotion of MTW9/PL rat mammary tumor cells in culture, platelet extracts alone were able to support growth 5... | Platelet derived growth factor(s) for a hormone-responsive rat mammary tumor cell line. Mammary tumor cell growth factor(s) has been identified in extracts of platelets from both male and female rats, as well as in extracts prepared from pooled outdated human platelets. When assayed by the growth promotion of MTW9/PL r... | [
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PMID:30784 | The relationship between guilt and quality of drug experiences. | Consistent with predictions from Mosher's (1966) guilt construct, the present study found that high guilt males, compared with low guilt Ss, reported significantly less use of marijuana, depressant, stimulant and hallucinogenic drugs. Among all Ss who reported at least one use within each drug category, high guilt Ss r... | The relationship between guilt and quality of drug experiences. Consistent with predictions from Mosher's (1966) guilt construct, the present study found that high guilt males, compared with low guilt Ss, reported significantly less use of marijuana, depressant, stimulant and hallucinogenic drugs. Among all Ss who repo... | [
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PMID:30783 | Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts. | We have studied the intracellular binding of radioactive cobalamin by normal cultured human fibroblasts grown in medium containing [(57)Co]-cobalamin. We have also assessed the significance of defects in this binding activity exhibited by two classes of human mutants (cbl C and cbl D) each characterized by pleiotropic ... | Cobalamin binding and cobalamin-dependent enzyme activity in normal and mutant human fibroblasts. We have studied the intracellular binding of radioactive cobalamin by normal cultured human fibroblasts grown in medium containing [(57)Co]-cobalamin. We have also assessed the significance of defects in this binding activ... | [
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PMID:30781 | A new anticoagulant medication in cardiac valve replacement. | 1. In the mitral valve replacement with Starr-Edwards prosthetic ball valve, the major thromboembolism occurred in 20% of the patients with the silastic ball valve series compared with 6% in those with a metal ball valve series. 2. The anticoagulant effect of Warfarin became stable and the occurrence of thromboembolism... | A new anticoagulant medication in cardiac valve replacement. 1. In the mitral valve replacement with Starr-Edwards prosthetic ball valve, the major thromboembolism occurred in 20% of the patients with the silastic ball valve series compared with 6% in those with a metal ball valve series. 2. The anticoagulant effect of... | [
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PMID:30787 | The influence of fluoride on apatite formation from unstable supersaturated solutions at pH 7.4. | The present study was undertaken to examine the effect of fluoride on the formation of apatite in aqeous calcium phosphate suspensions prepared by spontaneous precipitation at pH 7.4. The most notable finding was that fluoride greatly curtailed or eliminated the appearance of octacalcium phosphate-like precursor phases... | The influence of fluoride on apatite formation from unstable supersaturated solutions at pH 7.4. The present study was undertaken to examine the effect of fluoride on the formation of apatite in aqeous calcium phosphate suspensions prepared by spontaneous precipitation at pH 7.4. The most notable finding was that fluor... | [
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PMID:30799 | Acid lipase: a histochemical and biochemical study using triton X100-naphtyl palmitate micelles. | Hydrolsis of a-naphtyl palmitate dispersed with the detergent Triton X-100 at acid pH was studied by a histochemical diazocoupling technique in both fixed sections and cultures of primate tissues as well as by a biochemical assay employing the same chromogenic substrate. Evidence for the exclusive hydrolysis of this ar... | Acid lipase: a histochemical and biochemical study using triton X100-naphtyl palmitate micelles. Hydrolsis of a-naphtyl palmitate dispersed with the detergent Triton X-100 at acid pH was studied by a histochemical diazocoupling technique in both fixed sections and cultures of primate tissues as well as by a biochemical... | [
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PMID:30800 | On testing the activity of proteases from human polymorphonuclear neutrophils on blood smears. | A cytochemical method is presented for the demonstration of proteases in human polymorphonuclear (PMN) neutrophils on fixed blood smears. This new technique is based on solubilization of proteases from PMN neutrophils by incubation with 0.25 M NaCl in borate buffer at pH 8.5 which leads to degradation of erythrocytes a... | On testing the activity of proteases from human polymorphonuclear neutrophils on blood smears. A cytochemical method is presented for the demonstration of proteases in human polymorphonuclear (PMN) neutrophils on fixed blood smears. This new technique is based on solubilization of proteases from PMN neutrophils by incu... | [
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PMID:30802 | The beta-adrenergic receptor of newborn mouse skin. | Binding of the potent beta-adrenergic antagonist [125I]iodohydroxybenzylpindolol ([125I]IHYP) to particulate preparations from newborn mouse skin was characterized. A number of criteria were used to establish that binding occurred to specific, high affinity beta-adrenergic receptors in the skin preparations. Thus speci... | The beta-adrenergic receptor of newborn mouse skin. Binding of the potent beta-adrenergic antagonist [125I]iodohydroxybenzylpindolol ([125I]IHYP) to particulate preparations from newborn mouse skin was characterized. A number of criteria were used to establish that binding occurred to specific, high affinity beta-adren... | [
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PMID:30803 | Modification of otitis media following vaccination with the capsular polysaccharide of Streptococcus pneumoniae in chinchillas. | An animal model was used to determine whether vaccination with the capsular polysaccharide of Streptococcus pneumoniae could alter the development of experimental otitis media induced by the same type of S. pneumoniae as the vaccine. Following vaccination with the capsular polysaccharide of S. pneumoniae type 7, 36(63%... | Modification of otitis media following vaccination with the capsular polysaccharide of Streptococcus pneumoniae in chinchillas. An animal model was used to determine whether vaccination with the capsular polysaccharide of Streptococcus pneumoniae could alter the development of experimental otitis media induced by the s... | [
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PMID:30804 | Correction of metabolic acidosis by the kidney during isometric expansion of extracellular fluid volume. | In dogs with chronic hypochloremic metabolic alkalosis associated with ECFV contraction, plasma [HCO-3] ([HCO-3]p) normalizes during expansion of ECFV with a solution containing Cl- and HCO-3 in concentrations duplicating those in the plasma before expansion (isometric expansion). The kidney selectively rejects adminis... | Correction of metabolic acidosis by the kidney during isometric expansion of extracellular fluid volume. In dogs with chronic hypochloremic metabolic alkalosis associated with ECFV contraction, plasma [HCO-3] ([HCO-3]p) normalizes during expansion of ECFV with a solution containing Cl- and HCO-3 in concentrations dupli... | [
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PMID:30806 | Analysis of the iron-binding sites of transferrin by isoelectric focussing. | 1. Human transferrin was labelled with ferric nitrilotriacetate (FeNTA) at one of its two metal binding sites by variation of the pH. 2. Four transferrin forms, transferrin, transferrin(Fe) (A-site), transferrin(Fe) (B-site) and transferrin(2Fe) could be separated on flat bed gels by isoelectric focussing. 3. Incubatio... | Analysis of the iron-binding sites of transferrin by isoelectric focussing. 1. Human transferrin was labelled with ferric nitrilotriacetate (FeNTA) at one of its two metal binding sites by variation of the pH. 2. Four transferrin forms, transferrin, transferrin(Fe) (A-site), transferrin(Fe) (B-site) and transferrin(2Fe... | [
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PMID:30807 | [Induction of tyrosine aminotransferase (EC 2.5.1.5) by nicotinamide in rat liver (author's transl)]. | In intact rats nicotinamide induces an increase of tyrosine aminotransferase depending on the dose of nicotinamide. In adrenalectomized rats an increase of tyrosine aminotransferase activity is only found up to a dose of 250 mg/kg nicotinamide. The combination of nicotinamide with L-methionine and/or cortisone acetate ... | [Induction of tyrosine aminotransferase (EC 2.5.1.5) by nicotinamide in rat liver (author's transl)]. In intact rats nicotinamide induces an increase of tyrosine aminotransferase depending on the dose of nicotinamide. In adrenalectomized rats an increase of tyrosine aminotransferase activity is only found up to a dose ... | [
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PMID:30809 | Microbiology of recurrent and chronic otitis media with effusion. | A study was conducted of 274 children who had recurrent acute or chronic otitis media with effusion. Forty-five percent of the ears with effusion were found to contain bacteria, and 11% contained bacteria that were "probable pathogens" (S. pneumoniae, H. influenzae, and S. pyogenes). Bacteria were also found in 40% of ... | Microbiology of recurrent and chronic otitis media with effusion. A study was conducted of 274 children who had recurrent acute or chronic otitis media with effusion. Forty-five percent of the ears with effusion were found to contain bacteria, and 11% contained bacteria that were "probable pathogens" (S. pneumoniae, H.... | [
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PMID:30810 | Angiography of the testicular artery as a diagnostic aid in boys with nonpalpable testis. | Selective angiography of the testicular artery was performed in 12 boys (age 3-14 yr) with nonpalpable testis. The angiographic, operative, and microscopic findings are described. True aplasia was diagnosed in seven patients. In three patients previously operated upon, the second exploration was facilitated by angiogra... | Angiography of the testicular artery as a diagnostic aid in boys with nonpalpable testis. Selective angiography of the testicular artery was performed in 12 boys (age 3-14 yr) with nonpalpable testis. The angiographic, operative, and microscopic findings are described. True aplasia was diagnosed in seven patients. In t... | [
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PMID:30812 | Time-dependent deformation of some direct compression excipients. | Three techniques were used to compare the time-dependent deformation of microfine cellulose (Elcema G250), anhydrous lactose, dicalcium phosphate dihydrate (Emcompress), modified starch (Sta-Rx 1500) and sodium chloride. (1) In stress-relaxation experiments using a reciprocating tablet machine, none of the materials be... | Time-dependent deformation of some direct compression excipients. Three techniques were used to compare the time-dependent deformation of microfine cellulose (Elcema G250), anhydrous lactose, dicalcium phosphate dihydrate (Emcompress), modified starch (Sta-Rx 1500) and sodium chloride. (1) In stress-relaxation experime... | [
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PMID:30813 | Phospholipase inactivation induced by an amino-piperazine derivative: a study at the lipid-water interface. | 1-Amino-4-octylpiperazine, AP 22, an antiviral agent causes lipid accumulation in nervous tissue cultures. A physicochemical membrane model was used to demonstrate the formation of a lipid-AP 22 complex hindering phospholipase A2 action. A well defined amphiphilic balance seems essential to explain the mode of action o... | Phospholipase inactivation induced by an amino-piperazine derivative: a study at the lipid-water interface. 1-Amino-4-octylpiperazine, AP 22, an antiviral agent causes lipid accumulation in nervous tissue cultures. A physicochemical membrane model was used to demonstrate the formation of a lipid-AP 22 complex hindering... | [
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PMID:30815 | Baclofen (beta-p-chlorophenyl-gamma-aminobutyric acid) enhances [3H]gamma-aminobutyric acid (3H-GABA) release from rat globus pallidus in vitro. | The rat globus pallidus has been investigated as a possible model in which to study pre-synaptic GABA mechanisms in vitro. (+/-)-Baclofen (300 micrometer-1 mM) significantly enhanced the release of radioactivity from superfused slices of rat globus pallidus prelabelled with 3H-GABA in vitro. This releasing action was s... | Baclofen (beta-p-chlorophenyl-gamma-aminobutyric acid) enhances [3H]gamma-aminobutyric acid (3H-GABA) release from rat globus pallidus in vitro. The rat globus pallidus has been investigated as a possible model in which to study pre-synaptic GABA mechanisms in vitro. (+/-)-Baclofen (300 micrometer-1 mM) significantly e... | [
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PMID:30816 | The indirect sympathomimetic activity of etilefrine--a comparison with tyramine and ephedrine using [3H] noradrenaline. | The indirect sympathomimetic activity of etilefrine has been examined using the ventral caudal artery of the rat. This vessel has a rich sympathetic innervation and lends itself to studies on [3H]noradrenaline efflux from these sites. Etilefrine possessed significant indirect activity on the artery and this action, alt... | The indirect sympathomimetic activity of etilefrine--a comparison with tyramine and ephedrine using [3H] noradrenaline. The indirect sympathomimetic activity of etilefrine has been examined using the ventral caudal artery of the rat. This vessel has a rich sympathetic innervation and lends itself to studies on [3H]nora... | [
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PMID:30817 | Differences in responsiveness to adipokinetic agents between white epididymal and brown interscapula adipose tissue from rats. | Lipolytic activity was studied in brown and white adipose tissue of rats in vitro. 5-Hydroxy-tryptamine (5-HT), phenylephrine, noradrenaline, adrenaline and isoprenaline were used as adipokinetic agents. All stimulated lipolysis in brown adipose tissue, but 5-HT and phenyl-ephrine did not in white adipose tissue. A bet... | Differences in responsiveness to adipokinetic agents between white epididymal and brown interscapula adipose tissue from rats. Lipolytic activity was studied in brown and white adipose tissue of rats in vitro. 5-Hydroxy-tryptamine (5-HT), phenylephrine, noradrenaline, adrenaline and isoprenaline were used as adipokinet... | [
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PMID:30818 | The absorption of aliphatic carbamates from the rat colon. | The colonic absorptio n of a series of aliphatic carbamates has been studied using an in situ preparation in the rat. The absorption process appeared to be passive and no metabolism by the colon membrane was detected. A linear correlation between the logarithms of the absorption rate constants and apparent partition co... | The absorption of aliphatic carbamates from the rat colon. The colonic absorptio n of a series of aliphatic carbamates has been studied using an in situ preparation in the rat. The absorption process appeared to be passive and no metabolism by the colon membrane was detected. A linear correlation between the logarithms... | [
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PMID:30835 | Mechanism of fluorometric analysis of tetracycline involving metal complexation. | Tetracycline complexation with calcium and organic ligands was studied using fluorescence, circular dichroism, and solvent extraction methods. The results were used to interpret the mechanism of the commonly used fluorometric methods for the analysis of tetracycline in biological fluids. Tetracycline formed ternary cal... | Mechanism of fluorometric analysis of tetracycline involving metal complexation. Tetracycline complexation with calcium and organic ligands was studied using fluorescence, circular dichroism, and solvent extraction methods. The results were used to interpret the mechanism of the commonly used fluorometric methods for t... | [
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PMID:30836 | Degradative behavior of a new bronchodilator, carbuterol, in aqueous solution. | The degradation kinetics of carbuterol in aqueous solution were investigated at 85 degrees and constant ionic strength over the pH 0.25--13.3 range under anaerobic conditions. The results demonstrated a complex kinetic pattern involving specific acid and specific base catalyses at the pH extremes. Degradation resulted ... | Degradative behavior of a new bronchodilator, carbuterol, in aqueous solution. The degradation kinetics of carbuterol in aqueous solution were investigated at 85 degrees and constant ionic strength over the pH 0.25--13.3 range under anaerobic conditions. The results demonstrated a complex kinetic pattern involving spec... | [
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PMID:30837 | Mechanism of hydrolysis of halogenated nitrosoureas. | The hydrolysis kinetics of halogenated nitrosoureas were investigated using chlorozotocin as a model. Evidence is presented to show that the hydrolytic reaction of halogenated nitrosoureas between pH 3 and 8 is a summation of spontaneous water and hydroxide-ion-catalyzed reactions; the later reaction is the sum of two ... | Mechanism of hydrolysis of halogenated nitrosoureas. The hydrolysis kinetics of halogenated nitrosoureas were investigated using chlorozotocin as a model. Evidence is presented to show that the hydrolytic reaction of halogenated nitrosoureas between pH 3 and 8 is a summation of spontaneous water and hydroxide-ion-catal... | [
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PMID:30838 | Potential antitumor agents via inhibitors of L-asparagine synthetase: substituted sulfonamides and sulfonyl hydrazides related to glutamine. | A series of 4-(substituted aminosulfonyl)- and 4-(substituted hydrazinosulfonyl)-2-aminobutanoic acids, compounds structurally related to glutamine, was synthesized as potential inhibitors of L-asparagine synthetase and subjected to screening as antitumor agents. Target amino acids were obtained by condensation of a bl... | Potential antitumor agents via inhibitors of L-asparagine synthetase: substituted sulfonamides and sulfonyl hydrazides related to glutamine. A series of 4-(substituted aminosulfonyl)- and 4-(substituted hydrazinosulfonyl)-2-aminobutanoic acids, compounds structurally related to glutamine, was synthesized as potential i... | [
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PMID:30839 | Hemolytic properties of synthetic glycosides. | Cholesteryl alpha-L-rhamnopyranoside, tigogenyl alpha-L-rhamnopyranoside, tigogenyl beta-D-fucopyranoside, smilagenyl beta-D-fucopyranoside, cholesteryl beta-maltoside, tigogenyl beta-maltoside, and smilagenyl beta-maltoside were synthesized and characterized. The rhamnosides and fucosides, as well as some other steroi... | Hemolytic properties of synthetic glycosides. Cholesteryl alpha-L-rhamnopyranoside, tigogenyl alpha-L-rhamnopyranoside, tigogenyl beta-D-fucopyranoside, smilagenyl beta-D-fucopyranoside, cholesteryl beta-maltoside, tigogenyl beta-maltoside, and smilagenyl beta-maltoside were synthesized and characterized. The rhamnosid... | [
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PMID:30840 | Intrinsic factor-mediated binding of cyanocobalamin to cholestyramine. | The intrinsic factor-mediated binding of cyanocobalamin to cholestyramine was studied in vitro under varying conditions of pH, added electrolyte, and bile salt. The intrinsic factor-cyanocobalamin complex was adsorbed strongly by the resin at pH 3 in the presence of neutral salt and low concentrations of glycocholic ac... | Intrinsic factor-mediated binding of cyanocobalamin to cholestyramine. The intrinsic factor-mediated binding of cyanocobalamin to cholestyramine was studied in vitro under varying conditions of pH, added electrolyte, and bile salt. The intrinsic factor-cyanocobalamin complex was adsorbed strongly by the resin at pH 3 i... | [
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0.0279... |
PMID:30841 | Antagonism by naloxone of narcotic-induced respiratory depression and analgesia. | Receptor mechanisms for narcotic-induced respiratory depression and analgesia were compared by apparent pA2 values of morphine-naloxone, levorphanol-naloxone and pentazocine-naloxone. The similarity of apparent pA2 values of the three compunds for respiratory depression suggests that morphine, levorphanol and pentazoci... | Antagonism by naloxone of narcotic-induced respiratory depression and analgesia. Receptor mechanisms for narcotic-induced respiratory depression and analgesia were compared by apparent pA2 values of morphine-naloxone, levorphanol-naloxone and pentazocine-naloxone. The similarity of apparent pA2 values of the three comp... | [
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PMID:30849 | The effect of beta adrenergic receptor blockade on the renin response to respiratory acidosis. | The effect of beta adrenergic blockade on the increase in plasma renin activity produced by acute respiratory acidosis was studied in chloralose anesthetized dogs. Sixteen mongrel dogs were given 4%, 8% and 12% CO2 in room air, successively. Propranolol (2 mg/Kg) was given to 8 dogs prior to CO2 inhalation. The other 8... | The effect of beta adrenergic receptor blockade on the renin response to respiratory acidosis. The effect of beta adrenergic blockade on the increase in plasma renin activity produced by acute respiratory acidosis was studied in chloralose anesthetized dogs. Sixteen mongrel dogs were given 4%, 8% and 12% CO2 in room ai... | [
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PMID:30853 | [Comparative characteristics of various anti-arrhythmia agents used under clinical conditions]. | Comparative clinical and experimental study of the efficacy of the currently used anti-arrhythmic agents was conducted on 610 patients (828 cases) with various disorders of the cardiac rhythm. The modern classification of these agents is given. The indications and contra-indications for the prescription of the drugs, t... | [Comparative characteristics of various anti-arrhythmia agents used under clinical conditions]. Comparative clinical and experimental study of the efficacy of the currently used anti-arrhythmic agents was conducted on 610 patients (828 cases) with various disorders of the cardiac rhythm. The modern classification of th... | [
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PMID:30855 | [Serumconcentrations of non esterified fatty acids during operative stress and blockade of betaadrenergic receptors (author's transl)]. | Every stress reaction leads to an increased, hormonelly induced mobilisation of fatty acids, the extent of which may be considered as a parameter of the aggression mechanism. In 15 patients with idiopathic trigeminal neuralgia, who were operated under neurolepthypalgesia, the problem of quantitative alterations of the ... | [Serumconcentrations of non esterified fatty acids during operative stress and blockade of betaadrenergic receptors (author's transl)]. Every stress reaction leads to an increased, hormonelly induced mobilisation of fatty acids, the extent of which may be considered as a parameter of the aggression mechanism. In 15 pat... | [
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0.015796... |
PMID:30856 | [The importance of changes in whole-body balance of sodium and noradrenaline in essential hypertension (author's transl)]. | In 22 patients with essential hypertension plasma levels and urine excretions of sodium and noradrenaline were studied before, during and after long-term beta-blockade with pindolol. The relation between mean blood pressure and the quotient of sodium-/noradrenaline-excretion changed during treatment (placebo r=-0.34; p... | [The importance of changes in whole-body balance of sodium and noradrenaline in essential hypertension (author's transl)]. In 22 patients with essential hypertension plasma levels and urine excretions of sodium and noradrenaline were studied before, during and after long-term beta-blockade with pindolol. The relation b... | [
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0.050682... |
PMID:30857 | [In vitro evaluation of adsorbents used in haemoperfusion (author's transl)]. | The properties of six adsorbents for Haemoperfusion were investigated in vitro: Amberlite XAD-2; Amberlite XAD-4; Haemocol; collodion coated charcoal; albumine-collodion encapsulated charcoal and activated carbon fibers. Carbromal and diazepam are most quickly removed from aqueous solutions by Amberlite XAD-2 and XAD-4... | [In vitro evaluation of adsorbents used in haemoperfusion (author's transl)]. The properties of six adsorbents for Haemoperfusion were investigated in vitro: Amberlite XAD-2; Amberlite XAD-4; Haemocol; collodion coated charcoal; albumine-collodion encapsulated charcoal and activated carbon fibers. Carbromal and diazepa... | [
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PMID:30858 | [Composition of the trace contaminants in the atmosphere of the Soiuz-22 space ship]. | The Soyuz-22 space cabin atmosphere was studied for volatile organic trace contaminants. By gas chromatography the following constituents were identified: methane, ethane, heptane, methanol, ethanol, n-propanol, acetaldehyde, acetone, ethyl benzene. Except for acetone, concentrations of the above compounds were close t... | [Composition of the trace contaminants in the atmosphere of the Soiuz-22 space ship]. The Soyuz-22 space cabin atmosphere was studied for volatile organic trace contaminants. By gas chromatography the following constituents were identified: methane, ethane, heptane, methanol, ethanol, n-propanol, acetaldehyde, acetone,... | [
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PMID:30868 | The pediatric nurse practitioner: origins and challenges. | During the past decade, a new health professional has evolved--the pediatric nurse practitioner (PNP). Responding to warnings of a shortage of primary care physicians, the American Academy of Pediatrics helped encourage programs to train PNPs who would provide well-child care, working under a physician's supervision. S... | The pediatric nurse practitioner: origins and challenges. During the past decade, a new health professional has evolved--the pediatric nurse practitioner (PNP). Responding to warnings of a shortage of primary care physicians, the American Academy of Pediatrics helped encourage programs to train PNPs who would provide w... | [
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PMID:30880 | Transport capacity, alkaline phosphatase activity and protein content of glutaraldehyde-treated cell forms of Escherichia coli. | Studies on the comparative transport capacity of various cell forms of Escherichia coli suggest that glutaraldehyde acts only in the outer regions of the cell envelope and to such an extent that transport of alpha-aminoisobutyric acid is reduced by 50%. Alkaline phosphatase activity in whole cells was severely impaired... | Transport capacity, alkaline phosphatase activity and protein content of glutaraldehyde-treated cell forms of Escherichia coli. Studies on the comparative transport capacity of various cell forms of Escherichia coli suggest that glutaraldehyde acts only in the outer regions of the cell envelope and to such an extent th... | [
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... |
PMID:30881 | Physico-chemical properties of mouse hepatitis virus (MHV-2) grown on DBT cell culture. | Some properties of a strain of mouse hepatitis virus, MHV-2, grown on DBT cells were determined using a plaque assay on the cells. Viral growth was not inhibited by the presence of actinomycin D or 5-iodo-2-deoxyuridine. MHV-2 was completely inactivated by ether, chloroform, sodium deoxycholate or beta-propiolactone, b... | Physico-chemical properties of mouse hepatitis virus (MHV-2) grown on DBT cell culture. Some properties of a strain of mouse hepatitis virus, MHV-2, grown on DBT cells were determined using a plaque assay on the cells. Viral growth was not inhibited by the presence of actinomycin D or 5-iodo-2-deoxyuridine. MHV-2 was c... | [
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PMID:30887 | Loss of the sole. | The sole of the foot in a wood merchant was lost when he trod on a circular saw which had been placed on the ground. The foot was resurfaced by immediate split skin grafts, and the result proved very satisfactory. The immediate grafting procedure took on the cancellous bone, and as an emergency procedure it is recommen... | Loss of the sole. The sole of the foot in a wood merchant was lost when he trod on a circular saw which had been placed on the ground. The foot was resurfaced by immediate split skin grafts, and the result proved very satisfactory. The immediate grafting procedure took on the cancellous bone, and as an emergency proced... | [
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PMID:30882 | [Fixation of free nitrogen in the soil and on the roots of citrus trees in the subtropics of the Georgian SSR]. | The rate of biological nitrogen fixation was determined by the acetylene technique in soils and on the roots of orange, mandarin and lemon trees growing in red, yellow, podzolic, alluvial brown forest, and humus-calcareous soils. The minimum nitrogen fixation in podzolic soils was 3--8 kg of nitrogen per hectare per ve... | [Fixation of free nitrogen in the soil and on the roots of citrus trees in the subtropics of the Georgian SSR]. The rate of biological nitrogen fixation was determined by the acetylene technique in soils and on the roots of orange, mandarin and lemon trees growing in red, yellow, podzolic, alluvial brown forest, and hu... | [
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PMID:30883 | [DNA synthesis and degradation in the cells of Bacillus stearothermophilus]. | ATP-dependent and ATP-independent synthesis of DNA was studied on nucleotide-permeable cells of Bacillus stearothermophilus. The effect of temperature, pH, ionic strength, and bivalent metal ions on both types of DNA synthesis was investigated as well as their susceptibility to an SH-blocking agent. The level of ATP-in... | [DNA synthesis and degradation in the cells of Bacillus stearothermophilus]. ATP-dependent and ATP-independent synthesis of DNA was studied on nucleotide-permeable cells of Bacillus stearothermophilus. The effect of temperature, pH, ionic strength, and bivalent metal ions on both types of DNA synthesis was investigated... | [
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PMID:30884 | [Exoprotease properties of Bacillus subtilis var. amyloliquefaciens capable of coagulating blood plasma]. | The properties of the homogeneous exoprotease preparation from Bacillus subtilis varamyloliquefaciens 759 possessing the coagulase activity were studied. The enzyme is an alkaline protease, has the isopoint at pH 7.8, and not only clots blood plasmo but also hydrolyses such protein substrates as casein, hemoglobin, fib... | [Exoprotease properties of Bacillus subtilis var. amyloliquefaciens capable of coagulating blood plasma]. The properties of the homogeneous exoprotease preparation from Bacillus subtilis varamyloliquefaciens 759 possessing the coagulase activity were studied. The enzyme is an alkaline protease, has the isopoint at pH 7... | [
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PMID:30893 | [Toxico-analytical study of tofizopam]. | For the legal-toxicological identification on the Grandaxin--a new minor tranquillant of benzodiazepine type--a new method have been worked out. Identification by layer-chromatography and determination by UV-spectrophotometry appeared to be suitable for the study of 5 postmortal cases. | [Toxico-analytical study of tofizopam]. For the legal-toxicological identification on the Grandaxin--a new minor tranquillant of benzodiazepine type--a new method have been worked out. Identification by layer-chromatography and determination by UV-spectrophotometry appeared to be suitable for the study of 5 postmortal ... | [
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PMID:30885 | [Dehydrogenase isoenzymatic spectrum of alanine, aspartic and glutamic acids in Candida albicans yeasts]. | The isoenzyme spectrum of dehydrogenases of alanine, aspartic and glutamic acids requiring NAD and NADP as cofactors was studied in Candida albicans. The spectrum of aspartate dehydrogenase was found to depend on a cofactor being used. The isoenzyme systems are related to proteins which posess various physico-chemical... | [Dehydrogenase isoenzymatic spectrum of alanine, aspartic and glutamic acids in Candida albicans yeasts]. The isoenzyme spectrum of dehydrogenases of alanine, aspartic and glutamic acids requiring NAD and NADP as cofactors was studied in Candida albicans. The spectrum of aspartate dehydrogenase was found to depend on ... | [
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PMID:30886 | [Acidophilic obligate thermophilic bacteria, Bacillus acidocal-darius, isolated from the hot springs and soil of Kunashir Island]. | Obligate thermophilic acidophilic cultures of Bacillus acidocaldarius were isolated from hot springs and soil of the Kunashir Island (the Kuril Islands) and Southern Sakhalin; their optimum temperature of growth is 65 degrees C and pH is 3.3--4.0. It has been shown for the first time that these organisms can be isolate... | [Acidophilic obligate thermophilic bacteria, Bacillus acidocal-darius, isolated from the hot springs and soil of Kunashir Island]. Obligate thermophilic acidophilic cultures of Bacillus acidocaldarius were isolated from hot springs and soil of the Kunashir Island (the Kuril Islands) and Southern Sakhalin; their optimum... | [
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PMID:30911 | Defining the histamine H2-receptor in brain: the interaction with LSD. | Two aspects of the complexities of the mode of action of drugs are described. One is the criteria and pitfalls of defining the interaction with specific receptors. The other is the need to consider each of the pharmacological effects of a drug as a concatenation of receptor events, because it has become clear that eac... | Defining the histamine H2-receptor in brain: the interaction with LSD. Two aspects of the complexities of the mode of action of drugs are described. One is the criteria and pitfalls of defining the interaction with specific receptors. The other is the need to consider each of the pharmacological effects of a drug as a ... | [
-0.04729769378900528,
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PMID:30927 | [Manipulated hyperacidification of autochthonous tumors]. | Measurement on 3,4-benzopyrene- and methylcholanthrene-induced tumours of the rat (and mouse) showed that the multiple established manipulated hyperacidification of transplantation tumours to values about pH 6 is possible also on autochthonous tumours. | [Manipulated hyperacidification of autochthonous tumors]. Measurement on 3,4-benzopyrene- and methylcholanthrene-induced tumours of the rat (and mouse) showed that the multiple established manipulated hyperacidification of transplantation tumours to values about pH 6 is possible also on autochthonous tumours. | [
-0.03533192351460457,
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... |
PMID:30928 | [Phylogenetic aspects of acquired immunity]. | A review of literature on phylogenesis of acquired immunity shows an increasing activity and potential of this complex apparatus. This system is responsible for the immunosurveillance, i.e. the control and recognition of transformed cells. Obviously the functions and morphology of the immune competent apparatus become ... | [Phylogenetic aspects of acquired immunity]. A review of literature on phylogenesis of acquired immunity shows an increasing activity and potential of this complex apparatus. This system is responsible for the immunosurveillance, i.e. the control and recognition of transformed cells. Obviously the functions and morphol... | [
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PMID:30929 | [The time lapse of the cytostatic effect of ifosfamide]. | The time lapse of the effect of ifosfamid on the solid DS carcinosarcoma has been studied using 204 Wistar rats. The main results and the conclusions are as follows: 1. The transplantability of the tumor is abolished two hours after the i.v. application of 180 mg/kg isofamid (cessation of tumor cell proliferation). 2. ... | [The time lapse of the cytostatic effect of ifosfamide]. The time lapse of the effect of ifosfamid on the solid DS carcinosarcoma has been studied using 204 Wistar rats. The main results and the conclusions are as follows: 1. The transplantability of the tumor is abolished two hours after the i.v. application of 180 mg... | [
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PMID:30930 | [Effect of different temperature fractions of RNA on allogenic inhibition of hematopoietic stem cells of mouse bone marrow and embryonal liver]. | In the system of non-syngeneic transfer of stem hemopoietic cells, the preliminary incubation of the cells of bone marrow or embryonic liver of the C57BL mice with different temperature RNA fractions isolated from the spleen of (CBAXC57BL) F1 was shown to lead to the complete or partial restoration of the colony formin... | [Effect of different temperature fractions of RNA on allogenic inhibition of hematopoietic stem cells of mouse bone marrow and embryonal liver]. In the system of non-syngeneic transfer of stem hemopoietic cells, the preliminary incubation of the cells of bone marrow or embryonic liver of the C57BL mice with different t... | [
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PMID:30932 | Effects of ovine hydatid cyst fluid in sheep before and after treatment with hydrocortisone, antihistamines and atropine. | The cardiovascular and respiratory responses to scolex-free ovine hydatid cyst fluid were studied in 65 sodium pentobarbital-anesthetized sheep. The arterial blood pressure (ABP), central venous pressure (CVP), stethogram and electrocardiogram were recorded. Intra-venous administration of 10 ml or less hydatid fluid br... | Effects of ovine hydatid cyst fluid in sheep before and after treatment with hydrocortisone, antihistamines and atropine. The cardiovascular and respiratory responses to scolex-free ovine hydatid cyst fluid were studied in 65 sodium pentobarbital-anesthetized sheep. The arterial blood pressure (ABP), central venous pre... | [
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PMID:30936 | Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage. | To test the hypothesis that birth asphyxia has a role in the etiology of intraventricular hemorrhage (IVH), blood was collected from the umbilical artery (UA) at birth in 28 premature infants of 26 to 29 weeks gestation and analyzed for hydrogen ion concentration [H+], PCO2, standard bicarbonate level, and lactic acid ... | Hypercarbia at birth: a possible role in the pathogenesis of intraventricular hemorrhage. To test the hypothesis that birth asphyxia has a role in the etiology of intraventricular hemorrhage (IVH), blood was collected from the umbilical artery (UA) at birth in 28 premature infants of 26 to 29 weeks gestation and analyz... | [
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PMID:30937 | Serum gamma-glutamyl transpeptidase acitvity: a chemical determinant of alcohol consumption during adolescence. | The drinking habits of 55 adolescents, aged 12 to 22 years, were evaluated in light of the current presumed upsurge in adolescent alcohol use. SGPT, SGOT, and alkaline phosphatase concentrations were essentially normal in all subjects. Serum gamma-glutamyl transpeptidase (GGTP) concentrations were elevated in 12 of 15 ... | Serum gamma-glutamyl transpeptidase acitvity: a chemical determinant of alcohol consumption during adolescence. The drinking habits of 55 adolescents, aged 12 to 22 years, were evaluated in light of the current presumed upsurge in adolescent alcohol use. SGPT, SGOT, and alkaline phosphatase concentrations were essentia... | [
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PMID:30933 | Acid-base and oxidation-reduction relationships. | pH, the symbol for "hydrogen-ion concentration", is a series of dimensionless "units" that have only general significance. The author shows that, when considered on the basis of the relationship to oxidation-reduction, the relative significance of any pair of coordinates becomes more significant. However, the theoretic... | Acid-base and oxidation-reduction relationships. pH, the symbol for "hydrogen-ion concentration", is a series of dimensionless "units" that have only general significance. The author shows that, when considered on the basis of the relationship to oxidation-reduction, the relative significance of any pair of coordinates... | [
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PMID:30934 | pH and Eh relationships in the body. | This report concerns application of the graphical method for representing pH and Eh relationships in macromolecular systems (see previous paper) to in vivo studies. The author presents reasons for concluding that controlled measurements of urine are satisfactory indicators of changes in pH and Eh in the body whereas bl... | pH and Eh relationships in the body. This report concerns application of the graphical method for representing pH and Eh relationships in macromolecular systems (see previous paper) to in vivo studies. The author presents reasons for concluding that controlled measurements of urine are satisfactory indicators of change... | [
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PMID:30940 | Rates of block by procaine and benzocaine and the procaine-benzocaine interaction at the node of Ranvier. | 1. Action potentials and their maximum rates of rise, VA, were measured in single myelinated nerve fibres of the frog, Rana esculenta at room temperature. 2. On applying 1 mM procaine (pH 7.2) at 20 Hz stimulus frequency, half of the final VA reduction was reached at ton = 0.27 s; on applying 0.5 mM benzocaine (pH 7,2)... | Rates of block by procaine and benzocaine and the procaine-benzocaine interaction at the node of Ranvier. 1. Action potentials and their maximum rates of rise, VA, were measured in single myelinated nerve fibres of the frog, Rana esculenta at room temperature. 2. On applying 1 mM procaine (pH 7.2) at 20 Hz stimulus fre... | [
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PMID:30941 | Chloride binding and the Bohr effect of human fetal erythrocytes and HbFII solutions. | 1. We have observed that the alkaline Bohr effect of washed human fetal erythrocytes was larger than in human adult intact red cells, in physiological conditions of pH, PCO2 and temperature. This was also observed independently of the presence of CO2 and of 2,3 diphosphoglycerate (fresh or stored erythrocytes). 2. Expe... | Chloride binding and the Bohr effect of human fetal erythrocytes and HbFII solutions. 1. We have observed that the alkaline Bohr effect of washed human fetal erythrocytes was larger than in human adult intact red cells, in physiological conditions of pH, PCO2 and temperature. This was also observed independently of the... | [
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0.0... |
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