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PMID:30552 | Angiotensin I-converting enzyme in human urine. | It was demonstrated that angiotensin I-converting enzyme was excreted in human urine. The mean activity of the enzyme in normal urine was found to be 0.38 +/- 0.04 (S.E.M.) units/day (n = 18) and the enzymic activity correlated well with the concentration of the excreted sodium (r = 0.76, p less than 0.005). Urinary an... | Angiotensin I-converting enzyme in human urine. It was demonstrated that angiotensin I-converting enzyme was excreted in human urine. The mean activity of the enzyme in normal urine was found to be 0.38 +/- 0.04 (S.E.M.) units/day (n = 18) and the enzymic activity correlated well with the concentration of the excreted ... | [
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PMID:30554 | The effect of bile on the crystallisation of calcium carbonate, a constituent of gallstones. | When calcium and bicarbonate ions were mixed at room temperature (approximately 20 degrees C) to give concentrations of 4 mmol/1 and 21 mmol/1 respectively and the pH of the solution was kept at 8.3, vaterite, a form of calcium carbonate, was precipitated almost immediately as spheres of diameter 45 micron. The crystal... | The effect of bile on the crystallisation of calcium carbonate, a constituent of gallstones. When calcium and bicarbonate ions were mixed at room temperature (approximately 20 degrees C) to give concentrations of 4 mmol/1 and 21 mmol/1 respectively and the pH of the solution was kept at 8.3, vaterite, a form of calcium... | [
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PMID:30555 | Determination of blood ionized calcium in a large segment of the normal adult population. | In two different laboratories ionized calcium was determined by use of a calcium selective electrode system of recent design in specimens of whole blood drawn from a total of 100 volunteers. Identical mean values were obtained in each laboratory. A small standard deviation was found supporting the view that [Ca2+] is n... | Determination of blood ionized calcium in a large segment of the normal adult population. In two different laboratories ionized calcium was determined by use of a calcium selective electrode system of recent design in specimens of whole blood drawn from a total of 100 volunteers. Identical mean values were obtained in ... | [
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PMID:30556 | Neuroendocrine control of prolactin in experimental animals. | Hypothalamic regulation of prolactin secretion in animals (mammals) and man appears to be similar, and no significant differences have yet been demonstrated. The hypothalamus contains neurotransmitters and polypeptides that can either inhibit or stimulate prolactin release, although the predominant influence under basa... | Neuroendocrine control of prolactin in experimental animals. Hypothalamic regulation of prolactin secretion in animals (mammals) and man appears to be similar, and no significant differences have yet been demonstrated. The hypothalamus contains neurotransmitters and polypeptides that can either inhibit or stimulate pro... | [
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PMID:30563 | Serum and urine phosphate during short-term beta-adrenergic blockade in healthy men. | Treatment of 6 healthy adult men with a beta-blocker, timolol, resulted in a rise in serum phosphate which was maintained for the 5 days of therapy. This rise was accompanied by a transient fall in urine phosphate and a rise in the tubular maximum for phosphate reabsorption per unit glomerular filtration rate (TmPO4/GF... | Serum and urine phosphate during short-term beta-adrenergic blockade in healthy men. Treatment of 6 healthy adult men with a beta-blocker, timolol, resulted in a rise in serum phosphate which was maintained for the 5 days of therapy. This rise was accompanied by a transient fall in urine phosphate and a rise in the tub... | [
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PMID:30564 | Physostigmine for cardiac and neurologic manifestations of phenothiazine poisoning. | Psychotropic drugs such as the phenothiazine neuroleptics and tricyclic antidepressants are known to cause electrocardiographic abnormalities as well as a central anticholinergic syndrome. Physostigmine is known to reverse the central muscarinic anticholinergic manifestations by inhibition of the enzyme cholinesterase.... | Physostigmine for cardiac and neurologic manifestations of phenothiazine poisoning. Psychotropic drugs such as the phenothiazine neuroleptics and tricyclic antidepressants are known to cause electrocardiographic abnormalities as well as a central anticholinergic syndrome. Physostigmine is known to reverse the central m... | [
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PMID:30596 | Parenteral treatment of acute psychotic patients with agitation: a review. | Representative studies which elucidate present treatment principles regarding parenteral administration of neuroleptics for acute psychoses with agitation are reviewed. "Rapid tranquillization" with drugs such as haloperidol generally appears preferable, but controlled comparisons with more conservative types of treatm... | Parenteral treatment of acute psychotic patients with agitation: a review. Representative studies which elucidate present treatment principles regarding parenteral administration of neuroleptics for acute psychoses with agitation are reviewed. "Rapid tranquillization" with drugs such as haloperidol generally appears pr... | [
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PMID:30597 | Intramuscular/oral lorazepam in acute alcohol withdrawal and incipient delirium tremens. | An open study was carried out in 21 chronic alcoholics with severe withdrawal symptoms and incipient delirium tremens to evaluate the efficacy of adjuvant treatment with intramuscular lorazepam (5mg). All symptoms subsided within 2 hours after a single injection and remained under control with oral lorazepam (mean dail... | Intramuscular/oral lorazepam in acute alcohol withdrawal and incipient delirium tremens. An open study was carried out in 21 chronic alcoholics with severe withdrawal symptoms and incipient delirium tremens to evaluate the efficacy of adjuvant treatment with intramuscular lorazepam (5mg). All symptoms subsided within 2... | [
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PMID:30598 | The use of a kymograph in a comparative trial of flunitrazepam and meprobamate in elderly patients. | A double-blind crossover trial was carried out in 31 hospitalized elderly patients receiving night-time sedation to compare the effects of flunitrazepam (0.5 mg) and meprobamate (200 mg). After 1 week on placebo, patients received 1-week's treatment with each drug in random order. Quality of sleep was assessed by a nur... | The use of a kymograph in a comparative trial of flunitrazepam and meprobamate in elderly patients. A double-blind crossover trial was carried out in 31 hospitalized elderly patients receiving night-time sedation to compare the effects of flunitrazepam (0.5 mg) and meprobamate (200 mg). After 1 week on placebo, patient... | [
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PMID:30599 | 3,4,5-Trimethoxybenzoic acid, a new mescaline metabolite in humans. | After ingestion of 400 mg of mescaline sulfate by human volunteers, 3,4,5-trimethoxybenzoic acid was isolated from urine and identified by gas chromatography-mass spectrometry. The amount of this anionic mescaline metabolite was found to be very low as compared with that of the well-konwn 3,4,5-trimethoxyphenylacetic a... | 3,4,5-Trimethoxybenzoic acid, a new mescaline metabolite in humans. After ingestion of 400 mg of mescaline sulfate by human volunteers, 3,4,5-trimethoxybenzoic acid was isolated from urine and identified by gas chromatography-mass spectrometry. The amount of this anionic mescaline metabolite was found to be very low as... | [
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PMID:30600 | Species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. | The disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac), a new nonsteroidal anti-inflammatory agent, has been studied in rat, rabbit, dog, rhesus monkey, and man. Animals were given single oral or parenteral doses of 5 or 50 mg/kg; man received approximately 3 mg/kg orally. Fecal ... | Species differences in the disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac) in rat, rabbit, dog, rhesus monkey, and man. The disposition and metabolism of 6,11-dihydro-11-oxodibenz[be]oxepin-2-acetic acid (isoxepac), a new nonsteroidal anti-inflammatory agent, has been studied ... | [
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PMID:30602 | Comparative physiological disposition of ellipticine in several animal species after intravenous administration. | The physiological dispositon of ellipticine (NSC 71795) has been studied in the mouse, rat, dog and monkey after administration of [1-14C]ellipticine at 6 mg/kg iv (3 mg/kg to monkey). Ellipticine was very rapidly distributed from the blood of all species and was deposited in tissues. The rate of elimination of ellipti... | Comparative physiological disposition of ellipticine in several animal species after intravenous administration. The physiological dispositon of ellipticine (NSC 71795) has been studied in the mouse, rat, dog and monkey after administration of [1-14C]ellipticine at 6 mg/kg iv (3 mg/kg to monkey). Ellipticine was very r... | [
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PMID:30601 | Biotransformation of methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate (ciclobendazole) in rats and dogs. | A major metabolite of ciclobendazole (methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate) excreted in the urine, bile, and feces of rats was methyl 5-cyclopropylcarbonyl-6-hydroxy-benzimidazolecarbamate, established by comparison of the proton magnetic resonance and mass spectra with that of the authentic compound. ... | Biotransformation of methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate (ciclobendazole) in rats and dogs. A major metabolite of ciclobendazole (methyl 5-cyclopropylcarbonyl-2-benzimidazolecarbamate) excreted in the urine, bile, and feces of rats was methyl 5-cyclopropylcarbonyl-6-hydroxy-benzimidazolecarbamate, est... | [
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PMID:30605 | Metabolism of haloforms to carbon monoxide. II. In vivo studies. | Administration of haloforms (trihalomethanes) to rats led to substantial elevations in blood carbon monoxide levels. The administration of 13C-bromoform led to the formation of similarly enriched 13CO. A dose-dependent relationship between bromoform dose and CO production was observed. It was found that phenobarbital, ... | Metabolism of haloforms to carbon monoxide. II. In vivo studies. Administration of haloforms (trihalomethanes) to rats led to substantial elevations in blood carbon monoxide levels. The administration of 13C-bromoform led to the formation of similarly enriched 13CO. A dose-dependent relationship between bromoform dose ... | [
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PMID:30603 | Characterization of the metabolites of ellipticine in rat bile. | The two major metabolites of ellipticine (NSC 71795) were isolated from rat bile by a combination of solvent extraction, partition column chromatography, and reverse phase high-performance liquid chromatography. Purification and structural elucidation of the bile products were aided by administration of the drug with a... | Characterization of the metabolites of ellipticine in rat bile. The two major metabolites of ellipticine (NSC 71795) were isolated from rat bile by a combination of solvent extraction, partition column chromatography, and reverse phase high-performance liquid chromatography. Purification and structural elucidation of t... | [
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PMID:30607 | Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat. | Hepatic blood flow can be estimated from the area under the blood or plasma concentration-time curve of a drug following an intravenous dose and either an oral or intraperitoneal dose. The validity of the method depends on several factors which alter the area under the curve, that is, hemodynamic interactions due to th... | Complications in the estimation of hepatic blood flow in vivo by pharmacokinetic parameters. The area under the curve after the concomitant intravenous and intraperitoneal (or intraportal) administration of acetaminophen in the rat. Hepatic blood flow can be estimated from the area under the blood or plasma concentrati... | [
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PMID:30613 | [Drug prevention of bronchial asthma: inhibition of histamine and exercise-induced asthma by a new anti-anaphylactic oral preparation (ketotifen) (author's transl)]. | The protective anti-asthmatic effect of a new anti-allergic drug with histaminolytic and anti-anaphylactic properties was tested in various controlled clinical studies of induced bronchospasm in asthmatic patients (provocation tests using a histamine aerosol, and exercise-induced asthma using a bicycle ergometer). The ... | [Drug prevention of bronchial asthma: inhibition of histamine and exercise-induced asthma by a new anti-anaphylactic oral preparation (ketotifen) (author's transl)]. The protective anti-asthmatic effect of a new anti-allergic drug with histaminolytic and anti-anaphylactic properties was tested in various controlled cli... | [
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PMID:30606 | Factors affecting the metabolism of [14C]acetylhydrazine in rats. | Some factors affecting the metabolism of the potent hepatotoxin, acetylhydrazine, were studied in rats. After ip administration of [14C]acetylhydrazine, 36% and 38% of the dose was recovered in the urine and as 14CO2, respectively. The major urinary metabolites were diacetylhydrazine and the pyruvic acid and alpha-oxog... | Factors affecting the metabolism of [14C]acetylhydrazine in rats. Some factors affecting the metabolism of the potent hepatotoxin, acetylhydrazine, were studied in rats. After ip administration of [14C]acetylhydrazine, 36% and 38% of the dose was recovered in the urine and as 14CO2, respectively. The major urinary meta... | [
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PMID:30610 | Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases. | The incubation of methimazole (1-methyl-2-thioimidazole, MMI) with rat hepatic microsomes led to the formation of 3-methyl-2-thiohydantoin and N-methylimidazole. In addition, an NADPH-stimulated binding of 14C and 35S from [14C]- and [35s]MMI to microsomal macromolecules was seen. Both the NADPH-stimulated N-methylimid... | Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases. The incubation of methimazole (1-methyl-2-thioimidazole, MMI) with rat hepatic microsomes led to the formation of 3-methyl-2-thiohydantoin and N-methylimidazole. In addition, an NADPH-stimulated binding of 14C and 35S from [14C]- and [35s... | [
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PMID:30616 | [Biochemistry of depression. Literature analysis]. | The author goes briefly over the metabolism of the main cerebral monoamines, the functioning of synapses, as well as the methods used in studying the biochemistry of depression. Beyond all existing contradictory results, a review of the main works in this field enables us to point out some leading ideas:--Depression wo... | [Biochemistry of depression. Literature analysis]. The author goes briefly over the metabolism of the main cerebral monoamines, the functioning of synapses, as well as the methods used in studying the biochemistry of depression. Beyond all existing contradictory results, a review of the main works in this field enables... | [
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PMID:30611 | Partial purification and characterization of dihydropyrimidinases from calf and rat liver. | The partial purification of rat and calf liver dihydropyrimidinase (EC 3.5.2.2) is described. Molecular weights of the native calf and rat liver enzymes were estimated by gel-filtration chromatography to be 252,000 and 266,000 daltons, respectively. Subunit molecular weights of the calf and rat liver enzyme were estima... | Partial purification and characterization of dihydropyrimidinases from calf and rat liver. The partial purification of rat and calf liver dihydropyrimidinase (EC 3.5.2.2) is described. Molecular weights of the native calf and rat liver enzymes were estimated by gel-filtration chromatography to be 252,000 and 266,000 da... | [
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PMID:30617 | Effects of adrenergic blocking agents on lipolysis and adenyl cyclase activity induced by vasoactive intestinal polypeptide (VIP). | VIP stimulates lipolysis and adenyl cyclase activity in the rat adipose tissue. VIP-induced lipolysis and adenyl cyclase activity are not affected by phenoxybenzamine. VIP-induced lipolysis is inhibited by propranolol but VIP-induced adenyl cyclase activity is not. | Effects of adrenergic blocking agents on lipolysis and adenyl cyclase activity induced by vasoactive intestinal polypeptide (VIP). VIP stimulates lipolysis and adenyl cyclase activity in the rat adipose tissue. VIP-induced lipolysis and adenyl cyclase activity are not affected by phenoxybenzamine. VIP-induced lipolysis... | [
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PMID:30619 | Effect of hydrazine, isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine on guanylate cyclase activity. | The chemical carcinogen hydrazine is a potent stimulator of guanylate cyclase. In the present investigation we found that three chemical carcinogens structurally related to hydrazine, isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine, decreased guanylate cyclase activity. It is of interest that hydr... | Effect of hydrazine, isonicotinic acid hydrazide, hydrazine sulfate, and dimethylhydrazine on guanylate cyclase activity. The chemical carcinogen hydrazine is a potent stimulator of guanylate cyclase. In the present investigation we found that three chemical carcinogens structurally related to hydrazine, isonicotinic a... | [
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PMID:30620 | Purification and properties of hexoasmine isomerase (EC5.3.1.19) from pig intestinal mucosa. | Hexosamine isomerase from pig intestinal mucosa was purified about 70-fold. The aminosugar product of the enzymatic reaction was identified as glucosamine 6-phosphate and amino acid product as glutamic acid. The pH optimum was 7.1 Km for fructose 6-phosphate was 6.3 X 10(-4) mol/1 and for L-glutamine 6.5 X 10(-4) mol/1... | Purification and properties of hexoasmine isomerase (EC5.3.1.19) from pig intestinal mucosa. Hexosamine isomerase from pig intestinal mucosa was purified about 70-fold. The aminosugar product of the enzymatic reaction was identified as glucosamine 6-phosphate and amino acid product as glutamic acid. The pH optimum was ... | [
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PMID:30621 | Modulation of rat guanylate cyclase activity in vitro by chemical carcinogens. | The nucleotide cyclic GMP has been reported to be involved in cell proliferation and malignant transformation. Nitroso chemical carcinogens activate the enzyme guanylate cyclase (EC 4.6.1.2) which catalyzes the production of cyclic GMP. The present investigation demonstrates that compounds from other major classes of c... | Modulation of rat guanylate cyclase activity in vitro by chemical carcinogens. The nucleotide cyclic GMP has been reported to be involved in cell proliferation and malignant transformation. Nitroso chemical carcinogens activate the enzyme guanylate cyclase (EC 4.6.1.2) which catalyzes the production of cyclic GMP. The ... | [
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PMID:30623 | CNS and pituitary effects of hypothalamic peptides and MSH. | The first part of this essay discussed the CNS effects of the pituitary peptide MSH. These investigations anticipated studies of the CNS effects of peptides found in the hypothalamus which were discussed in the second part of the essay. Some of the endocrine actions of the hypothalamic peptides upon the release of pitu... | CNS and pituitary effects of hypothalamic peptides and MSH. The first part of this essay discussed the CNS effects of the pituitary peptide MSH. These investigations anticipated studies of the CNS effects of peptides found in the hypothalamus which were discussed in the second part of the essay. Some of the endocrine a... | [
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PMID:30630 | Slow association-dissociation equilibrium of NADP-linked isocitrate dehydrogenase from beef liver in relation to catalytic activity. | In this paper experiments are reported which show evidence for a relation between quaternary structure and catalytic activity of cytoplasmic NADP-linked isocitrate dehydrogenase from beef liver. The inactivation of the enzyme occurring upon dilution and the plots of the catalytic activity versus the enzyme concentratio... | Slow association-dissociation equilibrium of NADP-linked isocitrate dehydrogenase from beef liver in relation to catalytic activity. In this paper experiments are reported which show evidence for a relation between quaternary structure and catalytic activity of cytoplasmic NADP-linked isocitrate dehydrogenase from beef... | [
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PMID:30631 | Nuclear-magnetic-resonance study of aggregations and conformations of melanostatin and related peptides. | The 1H and 13C nuclear magnetic resonance spectra of melanostatin (Pro-Leu-Gly-NH2) and related peptides (Pro-Leu-Gly, Z-Pro-Leu-Gly, Z-Pro-Leu-Gly-NH2 and Z-Pro-Leu-Gly-OCH3, where Z = benzyloxycarbonyl) were analysed in a variety of solvents. At physiological pH, the melanostatin molecule is N-protonated in aqueous s... | Nuclear-magnetic-resonance study of aggregations and conformations of melanostatin and related peptides. The 1H and 13C nuclear magnetic resonance spectra of melanostatin (Pro-Leu-Gly-NH2) and related peptides (Pro-Leu-Gly, Z-Pro-Leu-Gly, Z-Pro-Leu-Gly-NH2 and Z-Pro-Leu-Gly-OCH3, where Z = benzyloxycarbonyl) were analy... | [
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PMID:30632 | Histidine in the nucleotide-binding site of NADP-linked isocitrate dehydrogenase from pig heart. | Incubation of pig heart NADP-dependent isocitrate dehydrogenase with ethoxyformic anhydride (diethylpyrocarbonate) at pH 6.2 results in a 9-fold greater rate of loss of dehydrogenase than of oxalosuccinate decarboxylase activity. The rate constants for loss of dehydrogenase and decarboxylase activities depend on the ba... | Histidine in the nucleotide-binding site of NADP-linked isocitrate dehydrogenase from pig heart. Incubation of pig heart NADP-dependent isocitrate dehydrogenase with ethoxyformic anhydride (diethylpyrocarbonate) at pH 6.2 results in a 9-fold greater rate of loss of dehydrogenase than of oxalosuccinate decarboxylase act... | [
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PMID:30633 | Plasma hypoxanthine levels in pigs during acute hypoxemia. A correlation between lactate and base deficit concentrations. | Tissue hypoxia was induced in pigs by artificial ventilation with 6% O2 in N2 for 18 min. Base deficit, lactate and hypoxanthine increased linearily during this period, and were significantly higher than initial values in the course of 6 min of hypoxemia. High correlation coefficients between hypoxanthine and lactate (... | Plasma hypoxanthine levels in pigs during acute hypoxemia. A correlation between lactate and base deficit concentrations. Tissue hypoxia was induced in pigs by artificial ventilation with 6% O2 in N2 for 18 min. Base deficit, lactate and hypoxanthine increased linearily during this period, and were significantly higher... | [
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PMID:30635 | Stimulation of immune reactivity by methoxy-substituted glycerol ethers incorporated into the feed. | In mice, the plaque-forming cell response to sheep red blood cells was stimulated by a mixture of methoxy-substituted glycerol ethers isolated from Greenland shark liver oil and by synthetic 1-0-(2-methoxyhexadecyl)-glycerol, given in the diet. In preliminary experiments, this synthetic compound also increased the abil... | Stimulation of immune reactivity by methoxy-substituted glycerol ethers incorporated into the feed. In mice, the plaque-forming cell response to sheep red blood cells was stimulated by a mixture of methoxy-substituted glycerol ethers isolated from Greenland shark liver oil and by synthetic 1-0-(2-methoxyhexadecyl)-glyc... | [
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PMID:30636 | Effect of chronic clonidine treatment and withdrawal on tyrosine hydroxylase activity in peripheral ganglia and the locus coeruleus. | As is observed clinically, cessation of chronic clonidine treatment in the rat results in a syndrome characterized by sympathetic hyperactivity. After three weeks of chronic oral administration of clonidine, tyrosine hydroxylase (TOH) activity was unchanged in superior cervical ganglia and locus coeruleus, but was redu... | Effect of chronic clonidine treatment and withdrawal on tyrosine hydroxylase activity in peripheral ganglia and the locus coeruleus. As is observed clinically, cessation of chronic clonidine treatment in the rat results in a syndrome characterized by sympathetic hyperactivity. After three weeks of chronic oral administ... | [
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PMID:30638 | Effects of alpha-agonists on circulatory responses to somatic afferent nerve stimulation. | The effect of intracisternal (i.c.m.) injection of clonidine, noradrenaline, and piperoxane on the pressor response to electrical stimulation of a peripheral somatic afferent nerve was investigated using anaesthetized cats. It was found that noradrenaline caused a depression of the magnitude of the pressor response and... | Effects of alpha-agonists on circulatory responses to somatic afferent nerve stimulation. The effect of intracisternal (i.c.m.) injection of clonidine, noradrenaline, and piperoxane on the pressor response to electrical stimulation of a peripheral somatic afferent nerve was investigated using anaesthetized cats. It was... | [
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PMID:30639 | Behavioural evidence for GABAergic activity of the benzodiazepine flurazepam. | Following reports that unilateral intranigral injections of putative GABAergic drugs induce contralateral rotational behaviour in rats, the effects of similar injections of the benzodiazepine flurazepam have been studied. Flurazepam mimicked the effects of the GABA agonist muscimol and the GABA analogue baclofen by ind... | Behavioural evidence for GABAergic activity of the benzodiazepine flurazepam. Following reports that unilateral intranigral injections of putative GABAergic drugs induce contralateral rotational behaviour in rats, the effects of similar injections of the benzodiazepine flurazepam have been studied. Flurazepam mimicked ... | [
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PMID:30640 | The effects of HGCl2 and mersalyl on mechanisms regulating intracellular calcium and transmitter release. | HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transmitter release. These mercurials inhibited calcium transport of mitochondria and synaptosomal vesicles. Low... | The effects of HGCl2 and mersalyl on mechanisms regulating intracellular calcium and transmitter release. HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transm... | [
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PMID:30650 | Angiotensin, thirst, and sodium appetite: retrospect and prospect. | The fact that drinking in response to some hypovolemic stimuli was attenuated by nephrectomy but not by ureteric ligation led to the suggestion that the renal renin-angiotensin system may play a role in hypovolemic thirst. The isolation of a thirst factor from the kidney and the demonstration that this substance was re... | Angiotensin, thirst, and sodium appetite: retrospect and prospect. The fact that drinking in response to some hypovolemic stimuli was attenuated by nephrectomy but not by ureteric ligation led to the suggestion that the renal renin-angiotensin system may play a role in hypovolemic thirst. The isolation of a thirst fact... | [
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PMID:30653 | The effect of temperature on sperm motility. II. Is bacterial growth a factor? | The previous demonstration that sperm kept at body temperature (37 degrees C) had a marked deterioration in motility accompanied by an overgrowth of bacteria in the semen and a concomitant decrease in pH led to this study to test the hypothesis that the decrease in motility was caused by the bacteria or by bacterial al... | The effect of temperature on sperm motility. II. Is bacterial growth a factor? The previous demonstration that sperm kept at body temperature (37 degrees C) had a marked deterioration in motility accompanied by an overgrowth of bacteria in the semen and a concomitant decrease in pH led to this study to test the hypothe... | [
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PMID:30654 | [Endocrine apparatus of human gastric mucosa]. | Endocrine cells of the gastric fundal and pyloric mucosa in patients suffering from gastric and duodenal ulcers with different gastric juice acidity, were studied. At hyperacid ulcers, the number of argyrhilic endocrine cells of gastric fundus was increased to 218 +/- 21.1 as compared with the normal acidity 164 +/- 14... | [Endocrine apparatus of human gastric mucosa]. Endocrine cells of the gastric fundal and pyloric mucosa in patients suffering from gastric and duodenal ulcers with different gastric juice acidity, were studied. At hyperacid ulcers, the number of argyrhilic endocrine cells of gastric fundus was increased to 218 +/- 21.1... | [
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PMID:30655 | [Gastric secretion in rats during long-term histamine administration]. | The acid--forming, acid--neutralizing functions of the stomach, morphological state of its walls and level of histamine in the blood were studied in control rats and in rats subjected to continuous histamine administration. In the latter, intensive elevation of intragastric acidity in empty stomach, an increase in the ... | [Gastric secretion in rats during long-term histamine administration]. The acid--forming, acid--neutralizing functions of the stomach, morphological state of its walls and level of histamine in the blood were studied in control rats and in rats subjected to continuous histamine administration. In the latter, intensive ... | [
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PMID:30666 | Hemolytic anemia in patients receiving sulfasalazine. | Hemolytic anemia is a well-recognized complication of sulfasalazine treatment. 17 of 40 (43%) patients with inflammatory bowel disease receiving sulfasalazine had evidence of hemolysis as detected by starch gel electrophoresis. Only 47% (8) of patients with hemolysis had Heinz body formation. The hemoglobin was signifi... | Hemolytic anemia in patients receiving sulfasalazine. Hemolytic anemia is a well-recognized complication of sulfasalazine treatment. 17 of 40 (43%) patients with inflammatory bowel disease receiving sulfasalazine had evidence of hemolysis as detected by starch gel electrophoresis. Only 47% (8) of patients with hemolysi... | [
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PMID:30668 | In vitro binding of 2-acetaminofluorene to RNA and protein with rat liver microsomes. | Covalent binding of 2-acetaminofluorene[9-14C] with exogenous Torula yeast RNA and endogenous protein was investigated in liver microsome system in vitro. The binding to protein was 100 times higher than that to RNA. Requirement of NADPH, effectiveness of methylcholanthrene treatment, and inhibition by 7,8-benzoflavone... | In vitro binding of 2-acetaminofluorene to RNA and protein with rat liver microsomes. Covalent binding of 2-acetaminofluorene[9-14C] with exogenous Torula yeast RNA and endogenous protein was investigated in liver microsome system in vitro. The binding to protein was 100 times higher than that to RNA. Requirement of NA... | [
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PMID:30669 | Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. | Prostaglandin E2 (PGE2) level in rectal mucosa excised from 17 patients suffering from ulcerative colitis was 2-fold higher than that found in rectal mucosa of 17 normal subjects: 2.0 +/- 0.4 and 0.9 +/- 0.2 ng per mg of wet tissue, respectively. Accumulation of PGE 2 in 24-hr cultures of rectal mucosa specimens obtain... | Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Prostaglandin E2 (PGE2) level in rectal mucosa excised from 17 patients suffering from ulcerative colitis was 2-fold higher than that found in rectal mucosa of 17 normal subjects: 2.0 +/- 0.4 and 0.9... | [
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PMID:30670 | Effect of the acid secretory state on intramural pH of rabbit gastric mucosa. | Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to a relatively high concentration of luminal acid. HCl 120 mM, for 60 min, led t... | Effect of the acid secretory state on intramural pH of rabbit gastric mucosa. Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to ... | [
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PMID:30676 | Uneven and transient secretin release after a liquid test meal. | In order to test the hypothesis that secretin may be released intermittently after feeding, the plasma secretin concentration was measured at short intervals, and the duodenal pH continuously recorded, after a liquid test meal in 10 human subjects. Secretin was measured with a radioimmunoassay in which the entire molec... | Uneven and transient secretin release after a liquid test meal. In order to test the hypothesis that secretin may be released intermittently after feeding, the plasma secretin concentration was measured at short intervals, and the duodenal pH continuously recorded, after a liquid test meal in 10 human subjects. Secreti... | [
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PMID:30679 | Gastroesophageal reflux and bleeding esophageal varices. | The incidence of gastroesophageal reflux was evaluated with the use of a pH probe in 12 patients with cirrhosis and recent variceal hemorrhage and in 15 healthy control subjects. Short episodes of reflux occurred in 42% of the patients and in 47% of the controls. During an observation period of 1 hr, the cumulative dur... | Gastroesophageal reflux and bleeding esophageal varices. The incidence of gastroesophageal reflux was evaluated with the use of a pH probe in 12 patients with cirrhosis and recent variceal hemorrhage and in 15 healthy control subjects. Short episodes of reflux occurred in 42% of the patients and in 47% of the controls.... | [
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PMID:30680 | Topical effects of 16,16 dimethyl prostaglandin E2 on gastric acid secretion and mucosal permeability to hydrogen ions in dogs. | The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of the greater curvature of the stomach mounted in a double lumen chamber. This model permitted simultaneous evaluation of two segm... | Topical effects of 16,16 dimethyl prostaglandin E2 on gastric acid secretion and mucosal permeability to hydrogen ions in dogs. The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of ... | [
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PMID:30681 | Gastric secretion and basal gastrin concentration in bilharzial hepatic fibrosis. | Gastric secretion and fasting plasma gastrin levels were investigated in 26 patients with bilharzial hepatic fibrosis and 26 controls. The groups did not differ in their basal secretion. When stimulated by intravenous infusion of histamine the maximal acid output in patients with bilharzial hepatic fibrosis was signifi... | Gastric secretion and basal gastrin concentration in bilharzial hepatic fibrosis. Gastric secretion and fasting plasma gastrin levels were investigated in 26 patients with bilharzial hepatic fibrosis and 26 controls. The groups did not differ in their basal secretion. When stimulated by intravenous infusion of histamin... | [
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PMID:30682 | Secretion pattern of secretin in man: regulation by gastric acid. | Median concentration of plasma secretin in the fasting state in 11 achlorhydria patients, 17 normal subjects, eight duodenal ulcer patients, and 11 Zollinger-Ellison patients was 0.3, 1.2, 2.5, and 5.9 pmol x 1(-1), respectively. Aspiration of gastric acid normal subjects and duodenal ulcer patients was followed by a s... | Secretion pattern of secretin in man: regulation by gastric acid. Median concentration of plasma secretin in the fasting state in 11 achlorhydria patients, 17 normal subjects, eight duodenal ulcer patients, and 11 Zollinger-Ellison patients was 0.3, 1.2, 2.5, and 5.9 pmol x 1(-1), respectively. Aspiration of gastric ac... | [
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PMID:30683 | Short chain fatty acid absorption by the human large intestine. | Short chain fatty acid absorption from the human rectum has been studied in 46 subjects attending an obesity clinic, using a dialysis bag technique. From a mixed electrolyte solution, acetate concentrations fell from 97.0 to 64.2 mmol/l, and sodium from 97.8 to 85.1 mmol/l with respective net absorption rates of 8.1 an... | Short chain fatty acid absorption by the human large intestine. Short chain fatty acid absorption from the human rectum has been studied in 46 subjects attending an obesity clinic, using a dialysis bag technique. From a mixed electrolyte solution, acetate concentrations fell from 97.0 to 64.2 mmol/l, and sodium from 97... | [
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PMID:30684 | The effect of streptozotocin analogues on guanylate cyclase activity. | Streptozotocin, a nitrosamide carcinogen, enhances the activity of guanylate cyclase. Six analogues of streptozotocin were studied in order to elucidate critical structure-activity relationships pertaining to the activation of guanylate cyclase. Analogue 1, known as chlorozotocin, has a nitroso group and increased guan... | The effect of streptozotocin analogues on guanylate cyclase activity. Streptozotocin, a nitrosamide carcinogen, enhances the activity of guanylate cyclase. Six analogues of streptozotocin were studied in order to elucidate critical structure-activity relationships pertaining to the activation of guanylate cyclase. Anal... | [
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PMID:30685 | Reconstitution of rabbit muscle aldolase after dissociation and denaturation at alkaline pH. | Tetrameric rabbit muscle aldolase is dissociated to the inactive monomer at strongly alkaline pH (pH greater than or equal to 12). As shown by sedimentation velocity, fluorescence emission, and specific activity, the final profiles of dissociation, denaturation, and deactivation run parallel. Increasing incubation time... | Reconstitution of rabbit muscle aldolase after dissociation and denaturation at alkaline pH. Tetrameric rabbit muscle aldolase is dissociated to the inactive monomer at strongly alkaline pH (pH greater than or equal to 12). As shown by sedimentation velocity, fluorescence emission, and specific activity, the final prof... | [
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PMID:30690 | Nucleotides and coenzymes in nuclei isolated from rat liver. | In rat-liver nuclei, isolated by the non-aqueous technique, the concentrations and labelling rates of the purine moiety of acid-soluble nucleotides were determined and compared with corresponding data for non-fractionated tissue and nuclei-free cytoplasm. Livers were used from untreated rats, from rats with a highly st... | Nucleotides and coenzymes in nuclei isolated from rat liver. In rat-liver nuclei, isolated by the non-aqueous technique, the concentrations and labelling rates of the purine moiety of acid-soluble nucleotides were determined and compared with corresponding data for non-fractionated tissue and nuclei-free cytoplasm. Liv... | [
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PMID:30691 | Kawasaki disease: a 'new' pediatric enigma. | More than 250 cases of this puzzling illness, first described in Japan a decade ago, have now been reported in the United States. The etiology, epidemiology, and true incidence remain to be determined. But since some 2% of victims develop severe cardiac complications and some may die suddenly months after apparent comp... | Kawasaki disease: a 'new' pediatric enigma. More than 250 cases of this puzzling illness, first described in Japan a decade ago, have now been reported in the United States. The etiology, epidemiology, and true incidence remain to be determined. But since some 2% of victims develop severe cardiac complications and some... | [
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PMID:30692 | Endocrine pancreatic tumors. | The pathology and cell biology of endocrine pancreatic tumors are reviewed. It is probable that all these tumors are "functioning" in the sense that they elaborate hormones that cause more or less conspicuous clinical syndromes. Identification of such secretory products is essential for an optimal diagnosis, localizati... | Endocrine pancreatic tumors. The pathology and cell biology of endocrine pancreatic tumors are reviewed. It is probable that all these tumors are "functioning" in the sense that they elaborate hormones that cause more or less conspicuous clinical syndromes. Identification of such secretory products is essential for an ... | [
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PMID:30694 | Further characterization of Mycobacterium ulcerans toxin. | Mycobacterium ulcerans produces an exotoxin in culture which, when inoculated into guinea pig skin, causes inflammation, necrosis, edema, and other histopathological changes resembling those in infections of humans. The toxin was resistant to heat and to alkalies and was moderately acid labile. Toxic activity was destr... | Further characterization of Mycobacterium ulcerans toxin. Mycobacterium ulcerans produces an exotoxin in culture which, when inoculated into guinea pig skin, causes inflammation, necrosis, edema, and other histopathological changes resembling those in infections of humans. The toxin was resistant to heat and to alkalie... | [
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PMID:30695 | Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization. | Mutants of Streptococcus mutans were isolated which lack the enzyme activity L (+)-lactate dehydrogenase. Reversion studies indicate that the genetic defects are in the structural gene for the enzyme. The mutants produce less titratable acid from glucose, adhere better to hydroxyapatite, and accumulate more plaque when... | Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization. Mutants of Streptococcus mutans were isolated which lack the enzyme activity L (+)-lactate dehydrogenase. Reversion studies indicate that the genetic defects are in the structural gene for the enzyme. The mutants produce ... | [
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PMID:30696 | Effects of surface-active agents on neutrophil receptors. | An easily performed assay to identify the C3b and Fc receptors on human neutrophils was developed. Salmonella typhimurium were treated with fluorescein and then incubated in nonimmune fresh human serum, which led to C3b fixation via activation of the alternative pathway. Similarly, type II pneumococci were treated with... | Effects of surface-active agents on neutrophil receptors. An easily performed assay to identify the C3b and Fc receptors on human neutrophils was developed. Salmonella typhimurium were treated with fluorescein and then incubated in nonimmune fresh human serum, which led to C3b fixation via activation of the alternative... | [
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PMID:30697 | Protective ability of Salmonella ribosomal protein and RNA in inbred mice. | Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J, C3H/HeDub, and C3H/HeJ mice. Purified ribosomal components were also tested as immunogens in the inbred mice. Protein isolated from a Salmonella ribosomal fraction could protect all three mouse strains. Although purified RNA was s... | Protective ability of Salmonella ribosomal protein and RNA in inbred mice. Ribosomal vaccines prepared from Salmonella typhimurium were effective immunogens in A/J, C3H/HeDub, and C3H/HeJ mice. Purified ribosomal components were also tested as immunogens in the inbred mice. Protein isolated from a Salmonella ribosomal ... | [
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PMID:30698 | Characteristics of an adenovirus type 19 conjunctivitis isolate and evidence for a subgroup associated with epidemic conjunctivitis. | Although adneovirus type 19 (Ad19) was first described in 1955, this virus was not associated with disease until its isolation from outbreaks of conjunctivitis in 1973. A strain of Ad19 isolated from a case of conjunctivitis in Seattle in 1974 was compared with the reference strain (3911). Plaque number and size were e... | Characteristics of an adenovirus type 19 conjunctivitis isolate and evidence for a subgroup associated with epidemic conjunctivitis. Although adneovirus type 19 (Ad19) was first described in 1955, this virus was not associated with disease until its isolation from outbreaks of conjunctivitis in 1973. A strain of Ad19 i... | [
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PMID:30699 | Effect of pH on the growth and glucose metabolism of Neisseria gonorrhoeae. | This study examined the effect of pH on the metabolism of glucose by Neisseria gonorrhoeae. Radiorespirometric studies revealed that cells growing at pH 7.2 or 8.0 metabolized glucose primarily (ca. 80%) via the Entner-Doudoroff pathway. The remainder of the glucose was metabolized via the pentose phosphate pathway (ca... | Effect of pH on the growth and glucose metabolism of Neisseria gonorrhoeae. This study examined the effect of pH on the metabolism of glucose by Neisseria gonorrhoeae. Radiorespirometric studies revealed that cells growing at pH 7.2 or 8.0 metabolized glucose primarily (ca. 80%) via the Entner-Doudoroff pathway. The re... | [
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PMID:30700 | Factors affecting the aggregation of Actinomyces naeslundii during growth and in washed cell suspensions. | Various factors affecting the aggregation of Actinomyces naeslundii strain 12104 were studied. When the pH of glucose-supplemented growth medium fell below 5.5, the cells aggregated and formed microbial masses which tenaciously adhered to the culture vessels. When the organism was cultured in the same medium in the abs... | Factors affecting the aggregation of Actinomyces naeslundii during growth and in washed cell suspensions. Various factors affecting the aggregation of Actinomyces naeslundii strain 12104 were studied. When the pH of glucose-supplemented growth medium fell below 5.5, the cells aggregated and formed microbial masses whic... | [
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PMID:30701 | Mechanism of coaggregation between Actinomyces viscosus T14V and Streptococcus sanguis 34. | Actinomyces viscosus T14V and Streptococcus sanguis 34 coaggregate by a mechanism which is not inhibited by 1 M NaCl, is dextran independent, requires calcium, is pH dependent with an optimum at pH 8.0 to 8.5, and appears to require the interaction of a protein or glycoprotein on A. viscosus with a carbohydrate on S. s... | Mechanism of coaggregation between Actinomyces viscosus T14V and Streptococcus sanguis 34. Actinomyces viscosus T14V and Streptococcus sanguis 34 coaggregate by a mechanism which is not inhibited by 1 M NaCl, is dextran independent, requires calcium, is pH dependent with an optimum at pH 8.0 to 8.5, and appears to requ... | [
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PMID:30704 | A simple method of screening for antisperm antibodies in the human male. Detection of spermatozoal surface IgG with the direct mixed antiglobulin reaction carried out on untreated fresh human semen. | A simple and rapid test for the detection of antisperm antibodies of the IgG class on freely swimming spermatozoa in fresh human semen is described. The test is based on the formation of motile mixed agglutinates between erythrocytes sensitized with incomplete anti-Rh-antibodies and freely swimming spermatozoa with sur... | A simple method of screening for antisperm antibodies in the human male. Detection of spermatozoal surface IgG with the direct mixed antiglobulin reaction carried out on untreated fresh human semen. A simple and rapid test for the detection of antisperm antibodies of the IgG class on freely swimming spermatozoa in fres... | [
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PMID:30706 | Effect of endogenous and exogenous progesterone on human endometrial enzymes. | Activities of 9 enzymes were determined biochemically in the endometrium. In Trial I (five women) 25 mg progesterone were injected i.m. on day 9 of the cycle; and endometrial biopsy taken 24 hours later was compared with endometrium from day 10 and day 21, taken in two untreated cycles from the same volunteers. Similar... | Effect of endogenous and exogenous progesterone on human endometrial enzymes. Activities of 9 enzymes were determined biochemically in the endometrium. In Trial I (five women) 25 mg progesterone were injected i.m. on day 9 of the cycle; and endometrial biopsy taken 24 hours later was compared with endometrium from day ... | [
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PMID:30707 | The effect of antibody against a purified sperm-coating antigen on human sperm. | A purified fraction of human seminal plasma containing a sperm-coating antigen and two minor contaminants was used to immunize rabbits by intravenous route. An antiserum containing only the antibody against the sperm-coating antigen as examined by immunoelectrophoresis was obtained from one rabbit. The effect of this a... | The effect of antibody against a purified sperm-coating antigen on human sperm. A purified fraction of human seminal plasma containing a sperm-coating antigen and two minor contaminants was used to immunize rabbits by intravenous route. An antiserum containing only the antibody against the sperm-coating antigen as exam... | [
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PMID:30708 | An improved assay technique for the proteolytic activity of individual human spermatozoa. | An improved substrate-film technique has been developed for the assay of released proteinase from individual human spermatozoa. During the preparation of the thin gelatin membrane, it is pretreated with formaldehyde and NaOH. These agents alter the plasma membrane and the outer acrosomal membrane of the spermatozoon, f... | An improved assay technique for the proteolytic activity of individual human spermatozoa. An improved substrate-film technique has been developed for the assay of released proteinase from individual human spermatozoa. During the preparation of the thin gelatin membrane, it is pretreated with formaldehyde and NaOH. Thes... | [
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PMID:30709 | Effect of medroxyprogesterone acetate contraception on cytoplasmic estrogen receptor content of the human cervix uteri. | Specimens of cervical tissue from five women each on 150 mg and 450 mg regimens of medroxyprogesterone acetate (MPA) for contraceptive purposes, were obtained through punch biopsy 15 days after injection. In another group of five women each on the same contraceptive regimens, punch biopsies of the cervix uteri were obt... | Effect of medroxyprogesterone acetate contraception on cytoplasmic estrogen receptor content of the human cervix uteri. Specimens of cervical tissue from five women each on 150 mg and 450 mg regimens of medroxyprogesterone acetate (MPA) for contraceptive purposes, were obtained through punch biopsy 15 days after inject... | [
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PMID:30711 | The effect of norgestrel and clogestone on the spontaneous motility of the human fallopian tube. | Spontaneous isometric contractions in vitro of both isthmic and ampullary parts of the human fallopian tube were studied. The tubes were obtained during the early luteal phase of the menstrual cycle from patients undergoing abdominal hysterectomy and who had ingested clogestone acetate or norgestrel, either 1 or 12 hou... | The effect of norgestrel and clogestone on the spontaneous motility of the human fallopian tube. Spontaneous isometric contractions in vitro of both isthmic and ampullary parts of the human fallopian tube were studied. The tubes were obtained during the early luteal phase of the menstrual cycle from patients undergoing... | [
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PMID:30712 | Lactate and pyruvate utilization by the spermatozoa of infertile human males. | In studying the metabolic pathway of lactate and pyruvate in human spermatozoa from fertile and infertile subjects, pyruvate 1-C14 and lactate 1-C14 were used as substrates in a radiorespirometry system. Spermatozoa from patients with 20 +/- 2.0/10(6) spz/ml and decreased motility (group B) showed a more active decarbo... | Lactate and pyruvate utilization by the spermatozoa of infertile human males. In studying the metabolic pathway of lactate and pyruvate in human spermatozoa from fertile and infertile subjects, pyruvate 1-C14 and lactate 1-C14 were used as substrates in a radiorespirometry system. Spermatozoa from patients with 20 +/- ... | [
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PMID:30713 | Intrauterine device and pelvic inflammatory disease. | Using a retrospective case control design on 101 women with a first episode of acute pelvic inflammatory disease (PID), it was found that 15% were wearing an intrauterine device, as compared to 7% out of a control group of 101 women matched for age, marital status, and interval since their last pregnancy termination. N... | Intrauterine device and pelvic inflammatory disease. Using a retrospective case control design on 101 women with a first episode of acute pelvic inflammatory disease (PID), it was found that 15% were wearing an intrauterine device, as compared to 7% out of a control group of 101 women matched for age, marital status, a... | [
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PMID:30714 | Effect of kallikrein on bull sperm motility in vitro. | The application of kallikrein--a kinin-releasing porcine pancreatic kininogenase--exerted considerable stimulation of bull sperm motility in vitro. The kallikrein was used in two concentrations: 1 and 100 KU/ml semen. Both concentrations gave similar effect: at the 4th hour of incubation at room temperature the motilit... | Effect of kallikrein on bull sperm motility in vitro. The application of kallikrein--a kinin-releasing porcine pancreatic kininogenase--exerted considerable stimulation of bull sperm motility in vitro. The kallikrein was used in two concentrations: 1 and 100 KU/ml semen. Both concentrations gave similar effect: at the ... | [
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PMID:30715 | Serum and seminal plasma prolactin levels in oligospermia. | Prolactin concentration was estimated by radioimmunoassay in seminal plasma and serum of 26 oligospermic and 23 normospermic men. No significant difference was found in the mean serum prolactin concentration between normospermic and oligospermic subjects, but there was an inverse correlation between serum prolactin lev... | Serum and seminal plasma prolactin levels in oligospermia. Prolactin concentration was estimated by radioimmunoassay in seminal plasma and serum of 26 oligospermic and 23 normospermic men. No significant difference was found in the mean serum prolactin concentration between normospermic and oligospermic subjects, but t... | [
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PMID:30716 | A simple ambulatory method for removal of occult IUDs. | With the increased popularity of the IUD as a contraceptive method, there is a rise in the cases of occult IUDs as a result of the disappearance of the threads from the vagina. Our experience has shown that in the cases where the marker is missing, but the IUD is in the uterine cavity, it can be easily removed by using... | A simple ambulatory method for removal of occult IUDs. With the increased popularity of the IUD as a contraceptive method, there is a rise in the cases of occult IUDs as a result of the disappearance of the threads from the vagina. Our experience has shown that in the cases where the marker is missing, but the IUD is i... | [
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PMID:30717 | Pure crystalline estradiol pellet implantation for contraception. | The subcutaneous implantation of estradiol pellets was found to be a simple and effective contraceptive method with good patient acceptance and minimal untoward effects. The pellets (25 mg each) were implanted through a Kearn's trocar into the abdominal wall, 2.5 to 5 cm above and parallel to Poupart's ligament. The re... | Pure crystalline estradiol pellet implantation for contraception. The subcutaneous implantation of estradiol pellets was found to be a simple and effective contraceptive method with good patient acceptance and minimal untoward effects. The pellets (25 mg each) were implanted through a Kearn's trocar into the abdominal ... | [
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PMID:30718 | Definition of period of induction of deciduoma in the rat using ornithine decarboxylase as a marker of growth onset. | The activity of uterine ornithine decarboxylase (ODC) was measured during the 24 hours after systemic induction of decidualization. Following a latent period of 2.5 hours, activity rose and reached a peak of 5.6 +/- 1.1 fold at 5 hours after induction. The activity then declined and a second, lower peak was seen at 21 ... | Definition of period of induction of deciduoma in the rat using ornithine decarboxylase as a marker of growth onset. The activity of uterine ornithine decarboxylase (ODC) was measured during the 24 hours after systemic induction of decidualization. Following a latent period of 2.5 hours, activity rose and reached a pea... | [
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PMID:30719 | Electrophoretic patterns of total, nuclear, and flagellar proteins from ejaculated human spermatozoa. | By means of selective solubilization methods and slab gel electrophoresis, reproducible patterns of 19, 37, and 56 protein bands were found to be associated with nuclear, "flagellar," and total human spermatozoa, respectively. Forty protein bands were found between the molecular weight of 12,400 to 160,000 daltons. Twe... | Electrophoretic patterns of total, nuclear, and flagellar proteins from ejaculated human spermatozoa. By means of selective solubilization methods and slab gel electrophoresis, reproducible patterns of 19, 37, and 56 protein bands were found to be associated with nuclear, "flagellar," and total human spermatozoa, respe... | [
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PMID:30720 | Conservative correction of uterine anomalies in cases of congenital and posttraumatic infertility. | Uterine anomalies are due either to primary congenital malformations, or to secondary traumatic lesions of the intrauterine cavity as well as to pathology of the endometrium. The latter two etiologic factors create difficulties in the correct diagnosis of a congenital malformation and despite the convincing hysterosalp... | Conservative correction of uterine anomalies in cases of congenital and posttraumatic infertility. Uterine anomalies are due either to primary congenital malformations, or to secondary traumatic lesions of the intrauterine cavity as well as to pathology of the endometrium. The latter two etiologic factors create diffic... | [
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PMID:30721 | Studies on biochemical characteristics of an early decidual protein. | Previous work in our laboratory has demonstrated the specific synthesis of a soluble protein (A) in the rat endometrium on day L4 of pseudopregnancy 1 h after the decidual induction; the A protein synthesis being higher in the antimesometrial region (AMR) than in the mesometrial one. We have now examined in the AMR of ... | Studies on biochemical characteristics of an early decidual protein. Previous work in our laboratory has demonstrated the specific synthesis of a soluble protein (A) in the rat endometrium on day L4 of pseudopregnancy 1 h after the decidual induction; the A protein synthesis being higher in the antimesometrial region (... | [
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PMID:30722 | Release rate of testosterone and estrogens from polydimethylsiloxane implants for extended periods in vivo compared with loss in vitro. | Release rates of testosterone, estrone, and estradiol placed in chambers made from polydimethylsiloxane (PDS) tubing (Dow Corning "Silastic," 3.35 mm ID x 4.65 mm OD) were studied in 14 freemartin cattle with minimal or non-detectable endogenous hormone secretion, and in 0.9% saline:methanol (1:1) baths shaken at 38 de... | Release rate of testosterone and estrogens from polydimethylsiloxane implants for extended periods in vivo compared with loss in vitro. Release rates of testosterone, estrone, and estradiol placed in chambers made from polydimethylsiloxane (PDS) tubing (Dow Corning "Silastic," 3.35 mm ID x 4.65 mm OD) were studied in 1... | [
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PMID:30727 | Reversible sterilization. | The present techniques for sterilization of women consist of different methods to block the passage through the oviducts. The disadvantage of all techniques is that the possiblity of restoring fertility is very limited. The aim of the present study is to demonstrate a method of sterilization which is reversible. | Reversible sterilization. The present techniques for sterilization of women consist of different methods to block the passage through the oviducts. The disadvantage of all techniques is that the possiblity of restoring fertility is very limited. The aim of the present study is to demonstrate a method of sterilization w... | [
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PMID:30728 | The characterisation of thawed semen, and the timing and route of insemination associated with conception in the human. | The temporal and qualitative aspects of the conceptual process of a small number of pregnancies achieved by donor insemination have been analysed to understand the semen values required and the optimal insemination timing and route. | The characterisation of thawed semen, and the timing and route of insemination associated with conception in the human. The temporal and qualitative aspects of the conceptual process of a small number of pregnancies achieved by donor insemination have been analysed to understand the semen values required and the optima... | [
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PMID:30729 | The anti-reproductive pharmacology of LH-RH and agonistic analogues. | LH-RH and three particular ("super") analogues were evaluated for agonistic (ovulation-induction and short-term uterotrophic properties) and postcoital contraceptive activity in rodents. Additionally, LH-RH and/or a representative analogue (D-Ala6-des Gly10-Pro9-LH-RH ethylamide) were tested for postcoital contracepti... | The anti-reproductive pharmacology of LH-RH and agonistic analogues. LH-RH and three particular ("super") analogues were evaluated for agonistic (ovulation-induction and short-term uterotrophic properties) and postcoital contraceptive activity in rodents. Additionally, LH-RH and/or a representative analogue (D-Ala6-de... | [
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PMID:30730 | The effect of ovarian wedge resection and incision on circulating gonadotropin in patients with polycystic ovarian disease. | Wedge resection (WR) was performed in 12 women with polycystic ovarian disease (PCOD), and Incision was done in 4 PCOD patients without any resection of ovarian tissue. Serum LH, FSH, estradiol-17beta (E2), progesterone, and urinary 17 ketosteroid (17KS) were measured serially before and after surgery. Neither WR nor I... | The effect of ovarian wedge resection and incision on circulating gonadotropin in patients with polycystic ovarian disease. Wedge resection (WR) was performed in 12 women with polycystic ovarian disease (PCOD), and Incision was done in 4 PCOD patients without any resection of ovarian tissue. Serum LH, FSH, estradiol-17... | [
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PMID:30732 | Pharmacological treatment of obesity. | Obesity results when the ingestion of energy exceeds its utilization, leading to an excessive expansion of the adipose tissue mass. Current pharmacological therapy for the obese patient focuses primarily on reducing energy intake. Anorectic agents reduce food consumption by modifying central systems in the brain which ... | Pharmacological treatment of obesity. Obesity results when the ingestion of energy exceeds its utilization, leading to an excessive expansion of the adipose tissue mass. Current pharmacological therapy for the obese patient focuses primarily on reducing energy intake. Anorectic agents reduce food consumption by modifyi... | [
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PMID:30734 | The antimicrobial activity of urine of paraplegic patients receiving methenamine mandelate. | The antimicrobial activity of urine collected from adult male paraplegics ingesting methenamine mandelate (MM) was evaluated. The in vitro bacterial growth in urine from these patients was inhibited when the free formaldehyde (HCHO) concentration was 10 to 22 microgram per ml. When the HCHO concentration was in the reg... | The antimicrobial activity of urine of paraplegic patients receiving methenamine mandelate. The antimicrobial activity of urine collected from adult male paraplegics ingesting methenamine mandelate (MM) was evaluated. The in vitro bacterial growth in urine from these patients was inhibited when the free formaldehyde (H... | [
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PMID:30735 | Bladder surface mucin. Examination of possible mechanisms for its antibacterial effect. | We have previusly provided physiologic and histochemical data implicating the bladder surface mucin layer as an important new antibacterial defense mechanism. This mucin or its contents seems to act as an "antiadherence factor", inhibiting bacterial adherence to the bladder mucosa and thereby facilitating the removal o... | Bladder surface mucin. Examination of possible mechanisms for its antibacterial effect. We have previusly provided physiologic and histochemical data implicating the bladder surface mucin layer as an important new antibacterial defense mechanism. This mucin or its contents seems to act as an "antiadherence factor", inh... | [
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PMID:30733 | Direct and reflex myocardial effects of intracoronary administered contrast materials in the anesthetized and conscious dog: comparison of standard and newer contrast materials. | The direct and indirect actions on left ventricular dynamics of contrast material (sodium meglumine diatrizoate) currently used for coronary arteriography, modified ionic material (sodium meglumine calcium metrizoate) and non-ionic material (metrizamide) were assessed in conscious and anesthetized dogs. In both anesthe... | Direct and reflex myocardial effects of intracoronary administered contrast materials in the anesthetized and conscious dog: comparison of standard and newer contrast materials. The direct and indirect actions on left ventricular dynamics of contrast material (sodium meglumine diatrizoate) currently used for coronary a... | [
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PMID:30738 | [The hypertrophic obstructive cardiomyopathy (HOCM) of the newborn]. | A case of a newborn infant with clinical and angiocardiographic signs of hypertrophic obstructive cardiomyopathy (HOCM) is presented. The baby died after a short therapy with beta-blockers. Light- and electron-microscopic investigations showed severe disorganization of muscular cellular arrangement and disturbances of ... | [The hypertrophic obstructive cardiomyopathy (HOCM) of the newborn]. A case of a newborn infant with clinical and angiocardiographic signs of hypertrophic obstructive cardiomyopathy (HOCM) is presented. The baby died after a short therapy with beta-blockers. Light- and electron-microscopic investigations showed severe ... | [
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PMID:30739 | The effect of atebrine and an acridine analog (BCMA) on the coenzyme fluorescence spectra of cultured melanoma and Ehrlich ascites (EL2) cells. | Coenzyme fluorescence spectra of single living cells are due to free pyridine nucleotides (folded configuration), bound pyridine nucleotides (unfolded configuration) and a third component, possibly a mixture or flavins. Such spectra can be used to recognize possible differences in coenzyme composition between cell line... | The effect of atebrine and an acridine analog (BCMA) on the coenzyme fluorescence spectra of cultured melanoma and Ehrlich ascites (EL2) cells. Coenzyme fluorescence spectra of single living cells are due to free pyridine nucleotides (folded configuration), bound pyridine nucleotides (unfolded configuration) and a thir... | [
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PMID:30740 | Dynamics of respiratory VT response to isocapnic pHa forcing in chemodenervated cats. | Arterial blood pH (pHa) was continuously monitored in decerebrate or pentobarbital-anesthetized cats with a rapidly responding hydrogen ion sensor inserted into the aorta. Alveolar carbon dioxide partial pressure and pHa were controlled independently during infusions of 1 N NaHCO3 or 0.5 N HCl into the inferior vena ca... | Dynamics of respiratory VT response to isocapnic pHa forcing in chemodenervated cats. Arterial blood pH (pHa) was continuously monitored in decerebrate or pentobarbital-anesthetized cats with a rapidly responding hydrogen ion sensor inserted into the aorta. Alveolar carbon dioxide partial pressure and pHa were controll... | [
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PMID:30741 | Slow postcapillary changes in blood pH in vivo: titration with acetazolamide. | A stopped-flow pH electrode apparatus was used to investigate the mechanisms underlying slow changes in plasma pH (pHO) after blood leaves the pulmonary capillaries in carbonic anhydrase-inhibited animals. After acetazolamide was administered to an anesthetized dog or cat, arterial blood was withdrawn through the elect... | Slow postcapillary changes in blood pH in vivo: titration with acetazolamide. A stopped-flow pH electrode apparatus was used to investigate the mechanisms underlying slow changes in plasma pH (pHO) after blood leaves the pulmonary capillaries in carbonic anhydrase-inhibited animals. After acetazolamide was administered... | [
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PMID:30747 | ATP hydrolysis and synthesis by the membrane-bound ATP synthetase complex of Methanobacterium thermoautotrophicum. | The membrane-bound ATP synthetase complex of Methanobacterium thermoautotrophicum showed maximum activity for ATP hydrolysis at pH 8, at temperatures between 65 and 70 degrees C, and at an ATP-Mg2+ ratio of 0.5. Anaerobic conditions were not prerequisite for enzyme activity. The enzyme showed a Km value for ATP of 2 mM... | ATP hydrolysis and synthesis by the membrane-bound ATP synthetase complex of Methanobacterium thermoautotrophicum. The membrane-bound ATP synthetase complex of Methanobacterium thermoautotrophicum showed maximum activity for ATP hydrolysis at pH 8, at temperatures between 65 and 70 degrees C, and at an ATP-Mg2+ ratio o... | [
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PMID:30748 | Enchancement of streptococcal transformation yield by proteolytic enzymes. | Trypsin and other proteolytic enzymes, added together with transforming DNA or during cell-DNA contact to competent cultures of several streptococcal strains, enchanced (10 to 600%) the yield of genetic transformation (stimulation). With few exceptions, the level of stimulation was high (over 100%) when competence was ... | Enchancement of streptococcal transformation yield by proteolytic enzymes. Trypsin and other proteolytic enzymes, added together with transforming DNA or during cell-DNA contact to competent cultures of several streptococcal strains, enchanced (10 to 600%) the yield of genetic transformation (stimulation). With few exc... | [
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PMID:30749 | Degradation of 4-hydroxyphenylacetic acid by Trichosporon cutaneum. | Trichosporon cutaneum degraded 4-hydroxyphenylacetic acid to acetoacetic and malic acids. 3.4-Dihydroxyphenylacetic acid, an intermediate in the reaction sequence, underwent hydroxylation before the benzene ring was cleaved. | Degradation of 4-hydroxyphenylacetic acid by Trichosporon cutaneum. Trichosporon cutaneum degraded 4-hydroxyphenylacetic acid to acetoacetic and malic acids. 3.4-Dihydroxyphenylacetic acid, an intermediate in the reaction sequence, underwent hydroxylation before the benzene ring was cleaved. | [
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PMID:30750 | Coordination chemistry of microbial iron transport compounds: rhodotorulic acid and iron uptake in Rhodotorula pilimanae. | The mechanism by which iron uptake is facilitated by the siderophore rhodotorulic acid (RA) in the yeast Rhodotorula pilimanae was investigated with radioactively labeled Fe and RA and kinetically inert, chromic-substituted RA complexes. The weight of the evidence supports a model in which RA mediates iron transport to... | Coordination chemistry of microbial iron transport compounds: rhodotorulic acid and iron uptake in Rhodotorula pilimanae. The mechanism by which iron uptake is facilitated by the siderophore rhodotorulic acid (RA) in the yeast Rhodotorula pilimanae was investigated with radioactively labeled Fe and RA and kinetically i... | [
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PMID:30751 | Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli. | The cytosine liponucleotides CDP-diglyceride and dCDP-diglyceride are key intermediates in phospholipid biosynthesis in Escherichia coli (C. R. H. Raetz and E. P. Kennedy, J. Biol. Chem. 248:1098--1105, 1973). The enzyme responsible for their synthesis, CTP:phosphatidic acid cytidylytransferase, was solubilized from th... | Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli. The cytosine liponucleotides CDP-diglyceride and dCDP-diglyceride are key intermediates in phospholipid biosynthesis in Escherichia coli (C. R. H. Raetz and E. P. Kennedy, J. Biol. Chem. 248:1098--1105,... | [
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PMID:30752 | Effects of temperature on the autolytic enzyme system of Streptococcus faecalis. | The cellular autolytic reaction system in Streptococcus faecalis ATCC 9790 was analyzed for relative increases in reaction rates with increasing temperature by determination of Arrhenius activation energies (E). The systems examined were: (i) an isolated wall-enzyme complex in 0.01 M sodium phosphate, pH 6.9; (ii) expo... | Effects of temperature on the autolytic enzyme system of Streptococcus faecalis. The cellular autolytic reaction system in Streptococcus faecalis ATCC 9790 was analyzed for relative increases in reaction rates with increasing temperature by determination of Arrhenius activation energies (E). The systems examined were: ... | [
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PMID:30753 | Transformation in pneumococcus: protein content of eclipse complex. | A two-step purification of pneumococcal eclipse complex is described, which uses sucrose gradient sedimentation followed by agarose gel permeation chromatography. Purified complex contains, in addition to donor DNA single strands, macromolecular material that can be labeled with methionine or leucine during development... | Transformation in pneumococcus: protein content of eclipse complex. A two-step purification of pneumococcal eclipse complex is described, which uses sucrose gradient sedimentation followed by agarose gel permeation chromatography. Purified complex contains, in addition to donor DNA single strands, macromolecular materi... | [
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PMID:30754 | Salmonella typhimurium LT-2 mutants with altered glutamine synthetase levels and amino acid uptake activities. | To determine whether Salmonella typhimurium has a nitrogen control response, we have examined the regulation of nitrogen utilization in two mutants with fivefold and threefold elevations in their glutamine synthetase activities. The mutants do not require glutamine for growth on glucose--ammonia medium but do have alte... | Salmonella typhimurium LT-2 mutants with altered glutamine synthetase levels and amino acid uptake activities. To determine whether Salmonella typhimurium has a nitrogen control response, we have examined the regulation of nitrogen utilization in two mutants with fivefold and threefold elevations in their glutamine syn... | [
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PMID:30755 | Benzeneboronic acid selectively inhibits sporulation of Bacillis subtilis. | m-Aminobenzeneboronic acid at levels of 0.2 mM in nutrient broth medium selectively inhibited sporulation without appreciably altering vegetative growth. Significant inhibitory effects were seen even when it was added as late as 6 h after the end of logarithmic growth. The pH changes associated with growth and sporulat... | Benzeneboronic acid selectively inhibits sporulation of Bacillis subtilis. m-Aminobenzeneboronic acid at levels of 0.2 mM in nutrient broth medium selectively inhibited sporulation without appreciably altering vegetative growth. Significant inhibitory effects were seen even when it was added as late as 6 h after the en... | [
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0.035166... |
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