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PMID:30340 | Increasing halothane concentrations reduce nitroprusside dose requirement. | There has been no description of the hemodynamic dose-response relationship between halothane and sodium nitroprusside (SNP), although these drugs are used together frequently for induction of deliberate hypotension. Utilizing aortic root cannulation and thermister-tipped pulmonary artery catheterization, this relation... | Increasing halothane concentrations reduce nitroprusside dose requirement. There has been no description of the hemodynamic dose-response relationship between halothane and sodium nitroprusside (SNP), although these drugs are used together frequently for induction of deliberate hypotension. Utilizing aortic root cannul... | [
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PMID:30341 | Low-frequency positive pressure ventilation with extracorporeal carbon dioxide removal (LFPPV-ECCO2R): an experimental study. | We describe a new form of mechanical pulmonary ventilation, low-frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R). In a series of animal studies the rate of mechanical ventilation was 0.66, 1, 2, and 4 min-1 at a tidal volume of 3, 10, and 15 ml kg-1. We were able to maintain normal... | Low-frequency positive pressure ventilation with extracorporeal carbon dioxide removal (LFPPV-ECCO2R): an experimental study. We describe a new form of mechanical pulmonary ventilation, low-frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R). In a series of animal studies the rate of ... | [
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PMID:30347 | [Perforations of the dura mater during epidural anesthesia. The value of epidurography]. | The authors propose a pathogenic classification of perforations of the dura mater occurring during continuous epidural anaesthesia: according to the flow through the communication with the subarochnoid space. Two clinical forms of anaesthesia affecting the cord itself may be distinguished on this basis, one frequent an... | [Perforations of the dura mater during epidural anesthesia. The value of epidurography]. The authors propose a pathogenic classification of perforations of the dura mater occurring during continuous epidural anaesthesia: according to the flow through the communication with the subarochnoid space. Two clinical forms of ... | [
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PMID:30342 | Effects of pH on protein binding of lidocaine. | Protein binding of lidocaine (2.5, 5, 10, and 20 microgram/ml in fresh plasma was studied from pH 5.6 to pH 9.8. Percent binding of lidocaine was inversely related to hydrogen-ion and lidocaine concentrations. | Effects of pH on protein binding of lidocaine. Protein binding of lidocaine (2.5, 5, 10, and 20 microgram/ml in fresh plasma was studied from pH 5.6 to pH 9.8. Percent binding of lidocaine was inversely related to hydrogen-ion and lidocaine concentrations. | [
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PMID:30349 | [Psychiatric complications in patients under intensive care]. | Ten adult patients with psychiatric disorders in the intensive care ward were examined. The length of stay varied from one week to four months and mechanical ventilation was necessary for all patients. Their experience of intensive care and their psychosensorial problems were as follows: temperospatial disorientation, ... | [Psychiatric complications in patients under intensive care]. Ten adult patients with psychiatric disorders in the intensive care ward were examined. The length of stay varied from one week to four months and mechanical ventilation was necessary for all patients. Their experience of intensive care and their psychosenso... | [
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PMID:30350 | [Parenteral nutrition and concentrated amino acid solution]. | The authors report on their experience with a solution of amino acids concentrated at 25 gomegaN/liter in eighty patients on exclusive and total parenteral nutrition (TPN). The average duration of the TPN is 35.08 days. Azonutril 25 was given as nutritive melange, maintaining a calorie-nitrogen ratio of 150 to 200 calo... | [Parenteral nutrition and concentrated amino acid solution]. The authors report on their experience with a solution of amino acids concentrated at 25 gomegaN/liter in eighty patients on exclusive and total parenteral nutrition (TPN). The average duration of the TPN is 35.08 days. Azonutril 25 was given as nutritive mel... | [
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PMID:30351 | [Four cases of tracheoesophageal fistula associated with prolonged ventilation]. | On the basis of four cases of oesophago-tracheal fistulae developing in ventilated patients, the authors describe the pathogenesis of these lesions, related to circulatory disturbances in the tracheal mucosa in contact with the balloon of the balloon of the tracheal tube. The spontaneous course is rapidly fatal and the... | [Four cases of tracheoesophageal fistula associated with prolonged ventilation]. On the basis of four cases of oesophago-tracheal fistulae developing in ventilated patients, the authors describe the pathogenesis of these lesions, related to circulatory disturbances in the tracheal mucosa in contact with the balloon of ... | [
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PMID:30354 | [Visual identification of Doppler sounds in gas embolisms]. | The method of choice for the early detection of air metabolism during neurosurgical operations in a sitting position is that of continuous cardiac auscultation using Doppler effect ultrasound apparatus. In the present study, involving 15 patients, an air embolism was produced by the injection of 2 ml of CO2 into the ri... | [Visual identification of Doppler sounds in gas embolisms]. The method of choice for the early detection of air metabolism during neurosurgical operations in a sitting position is that of continuous cardiac auscultation using Doppler effect ultrasound apparatus. In the present study, involving 15 patients, an air embol... | [
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PMID:30355 | [Traumatic intoxication by an anticholinesterase agent]. | An unusual observation is reported concerning intoxication by an anticholinesterasic. In this case a traumatic blow was caused by an industrial liquid projected under high pressure and resulted in a true parenteral injection. This product, presumed not to be toxic, lead to the delayed appearance of a massive and eventu... | [Traumatic intoxication by an anticholinesterase agent]. An unusual observation is reported concerning intoxication by an anticholinesterasic. In this case a traumatic blow was caused by an industrial liquid projected under high pressure and resulted in a true parenteral injection. This product, presumed not to be toxi... | [
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PMID:30356 | [Anesthetic evidence of pheochromocytoma]. | The authors report the clinical case of a patients who underwent four anaesthetic inductions during a period of 3 months. Two were associated with severe acute hypertension making the intended operation impossible at that time. Thorough investigations led to a diagnosis of phaeochromocytoma. Reviewing the protocol of t... | [Anesthetic evidence of pheochromocytoma]. The authors report the clinical case of a patients who underwent four anaesthetic inductions during a period of 3 months. Two were associated with severe acute hypertension making the intended operation impossible at that time. Thorough investigations led to a diagnosis of pha... | [
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PMID:30379 | Calcium ion regulation in barnacle muscle fibers and its relation to force development. | It is possible to use the photoproteins aequorin and obelin within the slowly responding striated muscle films to provide both qualitative and quantitive information as to the nature of the calcium-dependent reactions for force development. It seems that these reactions are not in equilibrium with the Ca2+ during a tra... | Calcium ion regulation in barnacle muscle fibers and its relation to force development. It is possible to use the photoproteins aequorin and obelin within the slowly responding striated muscle films to provide both qualitative and quantitive information as to the nature of the calcium-dependent reactions for force deve... | [
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PMID:30380 | Intracellular and extracellular calcium ions in transmitter release at the neuromuscular synapse. | The theme of this presentation has been to show that the control of transmitter release at the neuromuscular synapse is achieved by extracellular and intracellular calcium. For the fast information transfer represented by the end-plate potential, the electrochemical gradient for calcium across the presynaptic membrane ... | Intracellular and extracellular calcium ions in transmitter release at the neuromuscular synapse. The theme of this presentation has been to show that the control of transmitter release at the neuromuscular synapse is achieved by extracellular and intracellular calcium. For the fast information transfer represented by ... | [
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PMID:30384 | [Cutaneous periarteritis nodosa. Critical study about 4 cases (author's transl)]. | Cutaneous form of periarteritis nodosa. Four personal cases are added to 70 cases of the previous literature. The clinical and biological picture of the cutaneous form of P.A.N. are different from the systemic one by the lack of visceral involvement and a noteworthy good long-term prognosis. Venous (superficial thrombo... | [Cutaneous periarteritis nodosa. Critical study about 4 cases (author's transl)]. Cutaneous form of periarteritis nodosa. Four personal cases are added to 70 cases of the previous literature. The clinical and biological picture of the cutaneous form of P.A.N. are different from the systemic one by the lack of visceral ... | [
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PMID:30387 | The graft-versus-host reaction in chickens: determination of some parameters. | Some aspects of the ""Graft-Versus-Host'' (GVH) reaction were studied in White Leghorn chickens by assessing the splenic response of recipients to an injection of lymphocytes from donors. The responses varied according to the origin of recipient embryos as well as to the source of the donor lymphocytes. Blood lymphocyt... | The graft-versus-host reaction in chickens: determination of some parameters. Some aspects of the ""Graft-Versus-Host'' (GVH) reaction were studied in White Leghorn chickens by assessing the splenic response of recipients to an injection of lymphocytes from donors. The responses varied according to the origin of recipi... | [
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PMID:30388 | A comparative study of three beta 1-adrenoreceptor blocking drugs with different degree of intrinsic stimulating activity (metoprolol, practolol and H 87/07) in patients with angina pectoris. | Three beta1-selective beta-blocker (metoprolol, practolol and H 87/07) were compared in 29 patients with stable angina pectoris. The main pharmacological difference between the three beta-blockers was their intrinsic stimulating activity (I.S.A.), metoprolol being devoid of I.S.A., practolol having moderate I.S.A. and ... | A comparative study of three beta 1-adrenoreceptor blocking drugs with different degree of intrinsic stimulating activity (metoprolol, practolol and H 87/07) in patients with angina pectoris. Three beta1-selective beta-blocker (metoprolol, practolol and H 87/07) were compared in 29 patients with stable angina pectoris.... | [
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PMID:30390 | [Nisin formation by immobilized cells of the lactic acid bacterium, Streptococcus lactis]. | The problem of microbial cell immobilization at present attracts the ever increasing attention of the scientists, since such organisms may be the source of various enzymes. Production of nizin by the immobilized cells of Str. lactis was studied. It was found that the cells of Str. lactis incorporated into polyacrylamid... | [Nisin formation by immobilized cells of the lactic acid bacterium, Streptococcus lactis]. The problem of microbial cell immobilization at present attracts the ever increasing attention of the scientists, since such organisms may be the source of various enzymes. Production of nizin by the immobilized cells of Str. lac... | [
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PMID:30391 | Efficiency of beef extract for the recovery of poliovirus from wastewater effluents. | The efficiency of poliovirus elution from fiber glass cartridge filters (K27), epoxy-fiber glass-asbestos filters (M780), and pleated cartridge filters was assessed by using 3% beef extract (pH 9.0) or 0.1 M glycine (pH 11.5). Poliovirus type I, strain LSc, was seeded into 20- to 25-gallon (ca. 75.6- to 95.6-liter) sam... | Efficiency of beef extract for the recovery of poliovirus from wastewater effluents. The efficiency of poliovirus elution from fiber glass cartridge filters (K27), epoxy-fiber glass-asbestos filters (M780), and pleated cartridge filters was assessed by using 3% beef extract (pH 9.0) or 0.1 M glycine (pH 11.5). Poliovir... | [
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PMID:30420 | Protection of rats from compound 48/80-induced lethality. A simple test for inhibitors of mast cell-mediated shock. | The dose of 0.5 mg/kg i.v. of compound 48/80 was lethal in 97.2% of the injected rats. Observations before death and at autopsy were in accordance with the basic effect of compound 48/80 in rats i.e. the sustained release of mast cell mediators, whose action on the cardiovascular system leads to circulatory collapse. T... | Protection of rats from compound 48/80-induced lethality. A simple test for inhibitors of mast cell-mediated shock. The dose of 0.5 mg/kg i.v. of compound 48/80 was lethal in 97.2% of the injected rats. Observations before death and at autopsy were in accordance with the basic effect of compound 48/80 in rats i.e. the ... | [
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PMID:30421 | Anticholinesterase activity of some butyrophenones. | The anticholinesterase (antiChE) activity of haloperidol, droperidol and trifluperidol was studied by employing dog plasma as a cholinesterase source and changes in arterial blood pressure, elecited by a mixture of acetylcholine (Ach) and dog plasma with or without those drugs, as an indicator of their antiChE activity... | Anticholinesterase activity of some butyrophenones. The anticholinesterase (antiChE) activity of haloperidol, droperidol and trifluperidol was studied by employing dog plasma as a cholinesterase source and changes in arterial blood pressure, elecited by a mixture of acetylcholine (Ach) and dog plasma with or without th... | [
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PMID:30422 | Effects of indenolol (YB-2), a new beta-adrenergic blocking agent, and its dextro isomer on the central nervous system of mice and rabbits. | Central depressant actions of a new beta-adrenergic blocking agent, indenolol (YB-2), and its dextro isomer were studied in mice and rabbits. d-Indenolol was less active than dl-indenolol in lowering of methamphetamine group toxicity and calming of fighting behavior, though muscle relaxant, hypolocomotive and anticonvu... | Effects of indenolol (YB-2), a new beta-adrenergic blocking agent, and its dextro isomer on the central nervous system of mice and rabbits. Central depressant actions of a new beta-adrenergic blocking agent, indenolol (YB-2), and its dextro isomer were studied in mice and rabbits. d-Indenolol was less active than dl-in... | [
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PMID:30418 | [Experimental analysis of interference between alpha-adrenergic stimulants with anti-hypertensive activity and the narcotic activity of pentobarbital]. | The interactions of 3 classical alpha-adrenergic antihypertensives of prevalently central type (St 155 or clonidine St 600; BR 750 or guanabenz) with the narcotic effects of pentobarbital have been investigated in the Mus musculus. Interferences between convulsant drugs and spontaneous and coordinatory motor activity w... | [Experimental analysis of interference between alpha-adrenergic stimulants with anti-hypertensive activity and the narcotic activity of pentobarbital]. The interactions of 3 classical alpha-adrenergic antihypertensives of prevalently central type (St 155 or clonidine St 600; BR 750 or guanabenz) with the narcotic effec... | [
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PMID:30423 | Influence of aminophylline or beta-adrenoceptor blockade on glucagon release by a vasoactive adenosine analogue. | The glucagon-releasing activity of adenosine-5'-ethyl-carboxamide (744-96) was studied in conscious dogs pretreated either with aminophylline or with bupranolol, a beta-adrenoceptor blocking drug. The adenosine antagonist, aminophylline, inhibited both the glucagon-releasing and the blood pressure lowering effects of 7... | Influence of aminophylline or beta-adrenoceptor blockade on glucagon release by a vasoactive adenosine analogue. The glucagon-releasing activity of adenosine-5'-ethyl-carboxamide (744-96) was studied in conscious dogs pretreated either with aminophylline or with bupranolol, a beta-adrenoceptor blocking drug. The adenos... | [
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PMID:30425 | [Importance of measuring blood volume by an isotope method in essential hypertension]. | Measurement of the blood volume in cases of essential hypertension has shown a negative correlation with increase in blood pressure. We have been able to distinguish a group of moderate hypertensives who are hypervolemic, and whose systemic effect is more marked than in the moderate hypovolemic type. Such cases respond... | [Importance of measuring blood volume by an isotope method in essential hypertension]. Measurement of the blood volume in cases of essential hypertension has shown a negative correlation with increase in blood pressure. We have been able to distinguish a group of moderate hypertensives who are hypervolemic, and whose s... | [
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PMID:30426 | Neuroleptic-induced prolactin level elevation and breast cancer: an emerging clinical issue. | This article reviews the evidence that neuroleptics may increase the risk of breast cancer via their effects on prolactin secretion. All available neuroleptics, including reserpine, raise serum prolactin levels. Elevated serum prolactin level increases the incidence of spontaneously occurring mammary tumors in mice, an... | Neuroleptic-induced prolactin level elevation and breast cancer: an emerging clinical issue. This article reviews the evidence that neuroleptics may increase the risk of breast cancer via their effects on prolactin secretion. All available neuroleptics, including reserpine, raise serum prolactin levels. Elevated serum ... | [
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PMID:30427 | Delusional unipolar depression: description and drug response. | This retrospective study describes the response of 13 delusional unipolar depressives to combination antipsychotic-tricyclic antidepressant drug therapy. The Research Diagnostic Criteria were used by two independent raters to verify the presence of a delusional, primary, unipolar, major depressive disorder. Thirteen pa... | Delusional unipolar depression: description and drug response. This retrospective study describes the response of 13 delusional unipolar depressives to combination antipsychotic-tricyclic antidepressant drug therapy. The Research Diagnostic Criteria were used by two independent raters to verify the presence of a delusi... | [
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PMID:30428 | Benzodiazepines in depressive disorders. | Some investigators have found benzodiazepines effective in the treatment of anxious depression and thus have argued that benzodiazepines were "antidepressants." We reviewed the literature on benzodiazepines in depressive disorders. Comparative studies indicate they are less effective than standard antidepressants in th... | Benzodiazepines in depressive disorders. Some investigators have found benzodiazepines effective in the treatment of anxious depression and thus have argued that benzodiazepines were "antidepressants." We reviewed the literature on benzodiazepines in depressive disorders. Comparative studies indicate they are less effe... | [
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PMID:30429 | Use of antidepressant drugs in schizophrenia. | This review surveys the therapeutic efficacy of tricyclic antidepressants and monoamine oxidase inhibitors in schizophrenic patients. In general, the use of these drugs alone was found not to be warranted in schizophrenia, except perhaps in the so-called pseudoneurotic subgroup. In most cases, combinations of antidepre... | Use of antidepressant drugs in schizophrenia. This review surveys the therapeutic efficacy of tricyclic antidepressants and monoamine oxidase inhibitors in schizophrenic patients. In general, the use of these drugs alone was found not to be warranted in schizophrenia, except perhaps in the so-called pseudoneurotic subg... | [
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PMID:30430 | The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis. | Intravenously administered methylphenidate, 0.5 mg/kg, causes a consistent rise in human serum growth hormone level, with peak values usually occurring 30 minutes after infusion. This rise is attenuated in patients receiving various antipsychotic medications administered on a long-term basis and is decreased in schizop... | The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis. Intravenously administered methylphenidate, 0.5 mg/kg, causes a consistent rise in human serum growth hormone level, with peak values usually occurring 30 minutes after infusion. This rise is attenuated in patients re... | [
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PMID:30431 | Clinical significance of an increased or decreased serum alkaline phosphatase level. | An increase in the level of serum alkaline phosphatase (ALP) may be caused by a wide variety of pathologic lesions that involve multiple organs, since the enzyme is an ubiquitous one. Before one attempts to identify a significant pathologic abnormality, the clinician should consider the possibility of a physiologic or ... | Clinical significance of an increased or decreased serum alkaline phosphatase level. An increase in the level of serum alkaline phosphatase (ALP) may be caused by a wide variety of pathologic lesions that involve multiple organs, since the enzyme is an ubiquitous one. Before one attempts to identify a significant patho... | [
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PMID:30433 | Metal chelate affinity chromatography of hamster interferon. | Syrian hamster interferon, produced by benzo(a)pyrene-transformed embryo cells does not display an affinity for Zn++ chelate-agarose. However, the interferon binds to Cu++ chelate-agarose and can be displaced from the column by a falling pH-gradient. The chromatography of crude hamster interferon preparation on a tande... | Metal chelate affinity chromatography of hamster interferon. Syrian hamster interferon, produced by benzo(a)pyrene-transformed embryo cells does not display an affinity for Zn++ chelate-agarose. However, the interferon binds to Cu++ chelate-agarose and can be displaced from the column by a falling pH-gradient. The chro... | [
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PMID:30438 | Orthodontic seminar: a realistic approach construction, adjustment and repair of appliances. | Details of the design and construction of removable and simple fixed appliances are presented. Equipment, instruments, and supplies are listed. Welding, soldering, banding and bonding are illustrated. Finally, step-by-step descriptions are given of first aid measures for the repair of fixed appliances applicable to the... | Orthodontic seminar: a realistic approach construction, adjustment and repair of appliances. Details of the design and construction of removable and simple fixed appliances are presented. Equipment, instruments, and supplies are listed. Welding, soldering, banding and bonding are illustrated. Finally, step-by-step desc... | [
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PMID:30439 | Myocardial infarction--the problems and prognosis: Paper 1. | Deaths from coronary heart disease and myocardial infarct may occur in previously undiagnosed subjects (the so called pre-hospital phase), in hospital following admission to a coronary care unit, or following discharge. Mortality in the pre-hospital phase has been estimated at 35--40 per cent. Within Australia the mort... | Myocardial infarction--the problems and prognosis: Paper 1. Deaths from coronary heart disease and myocardial infarct may occur in previously undiagnosed subjects (the so called pre-hospital phase), in hospital following admission to a coronary care unit, or following discharge. Mortality in the pre-hospital phase has ... | [
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PMID:30440 | Factors influencing the infarct: the place of beta-blockade in limiting infarct size. | The mechanisms whereby myocardial infarction in man is precipitated are not understood--largely because the event is usually well established by the time medical help is called, but also because the techniques available have not yet permitted analysis of the earliest changes. On the other hand, the consequences of myoc... | Factors influencing the infarct: the place of beta-blockade in limiting infarct size. The mechanisms whereby myocardial infarction in man is precipitated are not understood--largely because the event is usually well established by the time medical help is called, but also because the techniques available have not yet p... | [
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PMID:30441 | The role of long term beta-blockade after myocardial infarction: Paper 1. | The opinion is emerging that beta-blocking drugs have an important role in management of patients following acute myocardial infarction. Already beta-blocking drugs are accepted as the treatment of choice in hypertension and in angina pectoris--in the major risk factor and consequence respectively of coronary atheroscl... | The role of long term beta-blockade after myocardial infarction: Paper 1. The opinion is emerging that beta-blocking drugs have an important role in management of patients following acute myocardial infarction. Already beta-blocking drugs are accepted as the treatment of choice in hypertension and in angina pectoris--i... | [
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PMID:30442 | The role of long term beta-blockade after myocardial infarction: Paper 2. | Acute myocardial infarction is associated with pain, tissue damage and circulatory impairment. As a result of these changes, there is increased sympathetic drive to the heart in the form of increased sympathetic nerve activity and increased circulating catecholamines. | The role of long term beta-blockade after myocardial infarction: Paper 2. Acute myocardial infarction is associated with pain, tissue damage and circulatory impairment. As a result of these changes, there is increased sympathetic drive to the heart in the form of increased sympathetic nerve activity and increased circu... | [
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PMID:30443 | The role of long term beta-blockade after myocardial infarction: Paper 3. | For many years the search has gone on for suitable drug therapy to improve survival following myocardial infarction. Most recently, beta-adrenergic blockade has entered the lists. Naturally beta-blockade is used in the conventional way to combat angina pectoris following an infarct, and one can expect that 70 per cent ... | The role of long term beta-blockade after myocardial infarction: Paper 3. For many years the search has gone on for suitable drug therapy to improve survival following myocardial infarction. Most recently, beta-adrenergic blockade has entered the lists. Naturally beta-blockade is used in the conventional way to combat ... | [
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PMID:30444 | The role of long term beta-blockade after myocardial infarction: Paper 4. | The place of beta-blockade following myocardial infarction should be considered in two phases; the acute infarction, and the long term management after infarction. | The role of long term beta-blockade after myocardial infarction: Paper 4. The place of beta-blockade following myocardial infarction should be considered in two phases; the acute infarction, and the long term management after infarction. | [
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PMID:30445 | Susceptibility of orbiviruses to low pH and to organic solvents. | Six orbiviruses, Corriparta, Wallal, Eubenangee, D'Aguilar, Warrego and Mitchell River, were inactivated within 30 min in solutions of pH less than 6. All but Wallal virus resisted treatment with ether at 1 degrees for 22 h but only Corriparta virus resisted treatment with chloroform at 1 degrees for 22 h. The genomes ... | Susceptibility of orbiviruses to low pH and to organic solvents. Six orbiviruses, Corriparta, Wallal, Eubenangee, D'Aguilar, Warrego and Mitchell River, were inactivated within 30 min in solutions of pH less than 6. All but Wallal virus resisted treatment with ether at 1 degrees for 22 h but only Corriparta virus resis... | [
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PMID:30447 | Kinetics and reaction mechanism of potassium-activated aldehyde dehydrogenase from Saccharomyces cerevisiae. | Data from steady-state kinetic analysis of yeast K+-activated aldehyde dehydrogenase are consistent with a ternary complex mechanism. Evidence from alternative substrate analysis and product-inhibition studies supports an ordered sequence of substrate binding in which NAD+ is the leading substrate. A preincubation requ... | Kinetics and reaction mechanism of potassium-activated aldehyde dehydrogenase from Saccharomyces cerevisiae. Data from steady-state kinetic analysis of yeast K+-activated aldehyde dehydrogenase are consistent with a ternary complex mechanism. Evidence from alternative substrate analysis and product-inhibition studies s... | [
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PMID:30448 | Electron-paramagnetic-resonance studies on the redox properties of the molybdenum-iron protein of nitrogenase between +50 and -450 mV. | The midpoint potentials, Em, for the oxidation of the characteristic e.p.r. signal with g values near 4.3, 3.7 and 2.01, of the nitrogenase Mo-Fe proteins from a number of bacteria were measured. They were 0mV for Clostridium pasteurianum, -42mV for Azotobacter chroococcum and Azotobacter vinelandii, -95mV for Bacillus... | Electron-paramagnetic-resonance studies on the redox properties of the molybdenum-iron protein of nitrogenase between +50 and -450 mV. The midpoint potentials, Em, for the oxidation of the characteristic e.p.r. signal with g values near 4.3, 3.7 and 2.01, of the nitrogenase Mo-Fe proteins from a number of bacteria were... | [
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PMID:30449 | Elastin cross-linking in vitro. Studies on factors influencing the formation of desmosines by lysyl oxidase action on tropoelastin. | The formation of isodesmosine and desmosine in vitro by the action of lysyl oxidase on tropoelastin was studied. The synthesis of desmosines occurred in the absence of additional substances. The formation of desmosines was not affected by removal of molecular O2 from the reaction medium nor was it affected by the lack ... | Elastin cross-linking in vitro. Studies on factors influencing the formation of desmosines by lysyl oxidase action on tropoelastin. The formation of isodesmosine and desmosine in vitro by the action of lysyl oxidase on tropoelastin was studied. The synthesis of desmosines occurred in the absence of additional substance... | [
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PMID:30450 | Some properties of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from ox liver. | Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (EC 4.1.3.5) was purified from ox liver, and obtained essentially free from 3-oxoacyl-CoA thiolases. The kinetic behaviour, like that of the synthases from chicken liver and yeast, is compatible with a reaction pathway involving condensation of an acetyl-enzyme with... | Some properties of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from ox liver. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (EC 4.1.3.5) was purified from ox liver, and obtained essentially free from 3-oxoacyl-CoA thiolases. The kinetic behaviour, like that of the synthases from chicken liver and yeast, is c... | [
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PMID:30451 | Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. | A neutral proteinase secreted by rabbit synovial fibroblasts in parallel with specific collagenase was partially purified by ion-exchange chromatography. At pH 7.6 this proteinase degraded 35S-labelled bovine nasal proteoglycan and azo-casein. The enzymic activity was inhibited by EDTA, 1,10-phenanthroline and serum, w... | Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. A neutral proteinase secreted by rabbit synovial fibroblasts in parallel with specific collagenase was partially purified by ion-exchange chromatography. At pH 7.6 this proteinase degraded 35S-labelled bovine nasal proteoglycan and azo-casein. The e... | [
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PMID:30452 | Use of the sulphite adduct of nicotinamide-adenine dinucleotide to study ionizations and the kinetics of lactate dehydrogenase and malate dehydrogenase. | 1. The formation of the non-enzymic adduct of NAD(+) and sulphite was investigated. In agreement with others we conclude that the dianion of sulphite adds to NAD(+). 2. The formation of ternary complexes of either lactate dehydrogenase or malate dehydrogenase with NAD(+) and sulphite was investigated. The u.v. spectrum... | Use of the sulphite adduct of nicotinamide-adenine dinucleotide to study ionizations and the kinetics of lactate dehydrogenase and malate dehydrogenase. 1. The formation of the non-enzymic adduct of NAD(+) and sulphite was investigated. In agreement with others we conclude that the dianion of sulphite adds to NAD(+). 2... | [
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PMID:30453 | Biochemical applications of chemically induced nuclear polarization in phenols, peptides, catecholamines and related molecules. | A photochemical method for producing proton nuclear polarization in phenolic biogenic molecules such as tyrosyl polypeptides and phenolic amines is described. The nuclear polarization is due to the reversible hydrogen-atom transfer from the phenolic hydroxy group to triplet photoexcited xanthene-dye molecules. Typical ... | Biochemical applications of chemically induced nuclear polarization in phenols, peptides, catecholamines and related molecules. A photochemical method for producing proton nuclear polarization in phenolic biogenic molecules such as tyrosyl polypeptides and phenolic amines is described. The nuclear polarization is due t... | [
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PMID:30454 | The pH-dependence of sugar-transport and glycolysis in cultured Ehrlich ascites-tumour cells. | 1. pH-dependence of glycolysis has generally been ascribed to the effects of pH on the activities of glycolytic enzymes. The present study shows that sugar transport is pH-dependent in cultured Ehrlich ascites-tumour cells. 2. The rates of glucose consumption, of 3-O-methylglucose transport, and of 2-deoxyglucose trans... | The pH-dependence of sugar-transport and glycolysis in cultured Ehrlich ascites-tumour cells. 1. pH-dependence of glycolysis has generally been ascribed to the effects of pH on the activities of glycolytic enzymes. The present study shows that sugar transport is pH-dependent in cultured Ehrlich ascites-tumour cells. 2.... | [
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PMID:30461 | Characterization of cholesterol ester hydrolase activities in rabbit and guinea pig aortas. | Cholesterol ester hydrolase activity was determined in preparations of rabbit and guinea pig aorta utilizing micellar and glycerol-dispersed cholesterol oleate substrates. Both substrate preparations demonstrated an acid pH optimum of 4--5 for the soluble and particulate rabbit media cholesterol ester hydrolase, sugges... | Characterization of cholesterol ester hydrolase activities in rabbit and guinea pig aortas. Cholesterol ester hydrolase activity was determined in preparations of rabbit and guinea pig aorta utilizing micellar and glycerol-dispersed cholesterol oleate substrates. Both substrate preparations demonstrated an acid pH opti... | [
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PMID:30464 | Accuracy of an automated blood-gas analyser operated by untrained staff. | Performance of the IL 613 automatic blood-gas analyser has been assessed using a group of 100 "analysts" with no previous training or experience in the use of the instrument. Test material consisted of blood equilibrated to a known PO2 and PCO2 in a tonometer: pH estimations were carried out on thawed aliquots of a lar... | Accuracy of an automated blood-gas analyser operated by untrained staff. Performance of the IL 613 automatic blood-gas analyser has been assessed using a group of 100 "analysts" with no previous training or experience in the use of the instrument. Test material consisted of blood equilibrated to a known PO2 and PCO2 in... | [
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PMID:30465 | Comparative study of two long-acting tranquillizers for oral premedication. | Lorazepam 2.5 mg was compared with promethazine 50 mg as oral premedication in a double-blind study in women. The premedication was given at the same time to all patients on each operating list, and both drugs continued to be effective 6 h after ingestion. A similar number of patients considered each drug to have relie... | Comparative study of two long-acting tranquillizers for oral premedication. Lorazepam 2.5 mg was compared with promethazine 50 mg as oral premedication in a double-blind study in women. The premedication was given at the same time to all patients on each operating list, and both drugs continued to be effective 6 h afte... | [
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PMID:30467 | A study of naloxone and doxapram as agents for the reversal of neuroleptanalgesic respiratory depression in the conscious rabbit. | The effectiveness of naloxone and doxapram in reversing the respiratory depressant actions of fentanyl and droperidol in the rabbit has been examined. Both drugs did not reverse fully the depression of respiratory frequency produced by the neuroleptanalgesic agents. Doxapram also failed to reverse fully the depression ... | A study of naloxone and doxapram as agents for the reversal of neuroleptanalgesic respiratory depression in the conscious rabbit. The effectiveness of naloxone and doxapram in reversing the respiratory depressant actions of fentanyl and droperidol in the rabbit has been examined. Both drugs did not reverse fully the de... | [
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PMID:30469 | Collection, cryopreservation and subsequent viability of haemopoietic stem cells intended for treatment of chronic granulocytic leukaemia in blast-cell transformation. | We have stored at -196 degrees C peripheral blood buffy coat (BC) and bone marrow (BM) cells collected from 47 patients with chronic granulocytic leukaemia in the chronic phase. Dimethyl sulphoxide (DMSO) 10% was used as cryoprotective agent. As these cells include CFUc and probably pluripotential stem cells they may b... | Collection, cryopreservation and subsequent viability of haemopoietic stem cells intended for treatment of chronic granulocytic leukaemia in blast-cell transformation. We have stored at -196 degrees C peripheral blood buffy coat (BC) and bone marrow (BM) cells collected from 47 patients with chronic granulocytic leukae... | [
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PMID:30470 | Continuous fetal tissue pH recordings during labour. A preliminary report. | We made continuous fetal pH-measurement in 50 patients and showed a good correlation between tissue pH and umbilical artery, umbilical vein and the fetal scalp blood pH. There were practical problems in the use of the glass pH electrode. | Continuous fetal tissue pH recordings during labour. A preliminary report. We made continuous fetal pH-measurement in 50 patients and showed a good correlation between tissue pH and umbilical artery, umbilical vein and the fetal scalp blood pH. There were practical problems in the use of the glass pH electrode. | [
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PMID:30471 | Low pH dimerization of chymotrypsin in solution. | The mechanism of the acid dimerization of alpha-chymotrypsin in solution was reexamined using a number of chemical derivatives. Blocking of the carboxyl of Tyr-146, while that of ASP-64 remained free, eliminated completely the ability of alpha-chymotrypsin to dimerize, as did methylation of His-57. O-Acetylation of Tyr... | Low pH dimerization of chymotrypsin in solution. The mechanism of the acid dimerization of alpha-chymotrypsin in solution was reexamined using a number of chemical derivatives. Blocking of the carboxyl of Tyr-146, while that of ASP-64 remained free, eliminated completely the ability of alpha-chymotrypsin to dimerize, a... | [
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PMID:30475 | Phosphorus-31 nuclear magnetic resonance studies of active proton translocation in chromaffin granules. | ATP hydrolysis and proton translocation in chromaffin granules were followed using 31P nuclear magnetic resonance. The intragranular pH affects the resonance frequency of the gamma-phosphate of granular ATP. By measuring frequency vs. pH in solutions which simulate the intragranular matrix, this may be calibrated to gi... | Phosphorus-31 nuclear magnetic resonance studies of active proton translocation in chromaffin granules. ATP hydrolysis and proton translocation in chromaffin granules were followed using 31P nuclear magnetic resonance. The intragranular pH affects the resonance frequency of the gamma-phosphate of granular ATP. By measu... | [
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PMID:30476 | Synthesis and hydrolysis of ATP by intact chloroplasts under flash illumination and in darkness. | ATP concentrations were measured in isolated intact spinach chloroplasts under various light and dark conditions. The following results were obtained: (1) Even in darkened chloroplasts and in the absence of exogenous substrates, ATP levels in the chloroplast stroma were significant. They decreased on addition of glycer... | Synthesis and hydrolysis of ATP by intact chloroplasts under flash illumination and in darkness. ATP concentrations were measured in isolated intact spinach chloroplasts under various light and dark conditions. The following results were obtained: (1) Even in darkened chloroplasts and in the absence of exogenous substr... | [
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PMID:30477 | Responses of the a3 component of cytochrome c oxidase to substrate and ligand addition. | We have previously described a transient high spin ferric heme species in cytochrome c oxidase (EC 1.9.3.1) which represent a3+(3) (Beinert, H. and Shaw, R.W.(1977) Biochim. Biophys. Acta 462, 12u--130), and can be detected and quantitatively determined by EPR. We have now used out ability to generate this species to s... | Responses of the a3 component of cytochrome c oxidase to substrate and ligand addition. We have previously described a transient high spin ferric heme species in cytochrome c oxidase (EC 1.9.3.1) which represent a3+(3) (Beinert, H. and Shaw, R.W.(1977) Biochim. Biophys. Acta 462, 12u--130), and can be detected and quan... | [
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PMID:30478 | Proton-translocating cytochrome c oxidase in artificial phospholipid vesicles. | The proton translocating properties of cytochrome c oxidase have been studied in artificial phospholipid vesicles into the membranes of which the isolated and purified enzyme was incorporated. Initiation of oxidation of ferrocytochrome c by addition of the cytochrome, or by addition of oxygen to an anaerobic vesicle su... | Proton-translocating cytochrome c oxidase in artificial phospholipid vesicles. The proton translocating properties of cytochrome c oxidase have been studied in artificial phospholipid vesicles into the membranes of which the isolated and purified enzyme was incorporated. Initiation of oxidation of ferrocytochrome c by ... | [
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PMID:30479 | Surface charges on chloroplast membranes as studied by particle electrophoresis. | 1. Particle microelectrophoresis mobility studies have been conducted with chloroplast thylakoid membranes and with isolated intact chloroplasts. 2. The pH dependence of the electrophoretic mobility indicated that at pH values above 4.3 both membrane systems carry a net negative charge. 3. Chemical treatment of thylako... | Surface charges on chloroplast membranes as studied by particle electrophoresis. 1. Particle microelectrophoresis mobility studies have been conducted with chloroplast thylakoid membranes and with isolated intact chloroplasts. 2. The pH dependence of the electrophoretic mobility indicated that at pH values above 4.3 bo... | [
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PMID:30480 | Control of the Ca2+-triggered bioluminescence of Veretillum cynomorium lumisomes. | Calcium ions can trigger an emission of light from Veretillum cynomorium lumisomes (bioluminescent vesicles) under conditions where they are not lysed. This process does not require a metabolically-linked source of energy, but is dependent upon the nature of the ions present inside and outside the vesicles. The Ca2+-tr... | Control of the Ca2+-triggered bioluminescence of Veretillum cynomorium lumisomes. Calcium ions can trigger an emission of light from Veretillum cynomorium lumisomes (bioluminescent vesicles) under conditions where they are not lysed. This process does not require a metabolically-linked source of energy, but is dependen... | [
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PMID:30481 | Role of beta-carotene in the reaction centres of photosystems I and II of spinach chloroplasts prepared in non-polar solvents. | Spinach chloroplasts have been prepared nonaqueously using non-polar solvents (n-hexane, CCl4, n-hepatane) and the beta-carotene content extracted in a controlled manner. This procedure is reproducible and does not result in large structural or spectral changes of the chloroplasts. The organisation of the chlorophyll-p... | Role of beta-carotene in the reaction centres of photosystems I and II of spinach chloroplasts prepared in non-polar solvents. Spinach chloroplasts have been prepared nonaqueously using non-polar solvents (n-hexane, CCl4, n-hepatane) and the beta-carotene content extracted in a controlled manner. This procedure is repr... | [
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PMID:30483 | Erythrocyte membrane potentials determined by hydrogen ion distribution. | If the extracellular fluid is left unbuffered, dynamic membrane potential changes in the red blood cell may be determined from external pH readings. For some types of experiments it is necessary to accelerate H+ equilibration by adding minute amounts of hydrogen carriers. The method is independent of hematocrit over a ... | Erythrocyte membrane potentials determined by hydrogen ion distribution. If the extracellular fluid is left unbuffered, dynamic membrane potential changes in the red blood cell may be determined from external pH readings. For some types of experiments it is necessary to accelerate H+ equilibration by adding minute amou... | [
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PMID:30484 | The hyperpolarizing and depolarizing effects of 2,4-dinitrophenol on Ehrlich cells. | The ability of glucose to reverse the effects of dinitrophenol on amino acid uptake in Ehrlich cells is a function of pH. At pH 6.0, the presence of glucose does not reverse the inhibitory action of the uncoupler. Nearly complete restoration occurs with glucose at pH 7.4. At pH 8, the presence of glucose may cause a mo... | The hyperpolarizing and depolarizing effects of 2,4-dinitrophenol on Ehrlich cells. The ability of glucose to reverse the effects of dinitrophenol on amino acid uptake in Ehrlich cells is a function of pH. At pH 6.0, the presence of glucose does not reverse the inhibitory action of the uncoupler. Nearly complete restor... | [
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PMID:30485 | The effect of bovine serum albumin on partial reactions of palmitoyl-CoA chain elongation by rat liver microsomes. | In the absence of albumin, v/s curves for both condensation and overall chain elongation demonstrated that the specific activity for overall chain elongation was 3.7 times that of condensation. When the molar ratio of palmitoyl-CoA to albumin was greater than 2 : 1, the specific activity of chain elongation exceeded th... | The effect of bovine serum albumin on partial reactions of palmitoyl-CoA chain elongation by rat liver microsomes. In the absence of albumin, v/s curves for both condensation and overall chain elongation demonstrated that the specific activity for overall chain elongation was 3.7 times that of condensation. When the mo... | [
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PMID:30486 | Parvalbumins from coelacanth muscle. II. Amino acid sequence of the two less acidic components. | The primary structure of the two less acidic parvalbumins (pI = 5.44 and pI = 4.95) from coelacanth muscle (Latimeria chalumnae) has been determined. They differ only by the presence or absence of a N-terminal blocking group. By the use of the automatic degradation, 69 amino acids could be placed unambiguously in the N... | Parvalbumins from coelacanth muscle. II. Amino acid sequence of the two less acidic components. The primary structure of the two less acidic parvalbumins (pI = 5.44 and pI = 4.95) from coelacanth muscle (Latimeria chalumnae) has been determined. They differ only by the presence or absence of a N-terminal blocking group... | [
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PMID:30487 | The involvement of one of the three histidine residues of cow kappa-casein in the chymosin-initiated milk clotting process. | Cow kappa-casein has been modified by photo-oxidation in the presence of rose bengal and by the chemical reagents diethyl pyrocarbonate, 2-hydroxy-5-nitro-benzyl bromide and iodoacetic acid. Photo-oxidation resulted in the destruction of histidine and tryptophan residues and all of the histidines could be ethoxy-formyl... | The involvement of one of the three histidine residues of cow kappa-casein in the chymosin-initiated milk clotting process. Cow kappa-casein has been modified by photo-oxidation in the presence of rose bengal and by the chemical reagents diethyl pyrocarbonate, 2-hydroxy-5-nitro-benzyl bromide and iodoacetic acid. Photo... | [
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PMID:30488 | Structural interpretation of lanthanide binding to the basic pancreatic trypsin inhibitor by 1H NMR at 360 MHz. | The weak binding of lanthanides to the five carboxyl groups of the basic pancreatic trypsin inhibitor (hereafter termed "the inhibitor"), has been investigated in detail using high resolution 1H NMR at 360 MHz. Lanthanides bind to the C-terminus with an apparent binding constant of 30 M-1, and thus competitively inhibi... | Structural interpretation of lanthanide binding to the basic pancreatic trypsin inhibitor by 1H NMR at 360 MHz. The weak binding of lanthanides to the five carboxyl groups of the basic pancreatic trypsin inhibitor (hereafter termed "the inhibitor"), has been investigated in detail using high resolution 1H NMR at 360 MH... | [
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PMID:30489 | The effect of acid pH and citrate on the release and exchange of iron on rat transferrin. | The effect of acid pH and citrate on the exchange of iron between binding sites of rat transferrin has been studied. In the absence of citrate, diferric transferrin shows stepwise loss of iron atoms with the first atom of iron released at approximately pH 5.2. Citrate at physiologic concentrations (1.10(-3) M) or great... | The effect of acid pH and citrate on the release and exchange of iron on rat transferrin. The effect of acid pH and citrate on the exchange of iron between binding sites of rat transferrin has been studied. In the absence of citrate, diferric transferrin shows stepwise loss of iron atoms with the first atom of iron rel... | [
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PMID:30490 | Origin of the ribityl side-chain of riboflavin from the ribose moiety of guanosine triphosphate in Pichia guilliermondii yeast. | In wild-type cells and some riboflavin-deficient mutants of P. guilliermondii GTP is transformed to the ribitylated intermediates 2,5-diamino-6-hydroxy-4-ribitylaminopyrimidine and 5-amino-2,6-dihydroxy-4-ribitylaminopyrimidine of the riboflavin biosynthetic path. We were able to show that these compounds were formed i... | Origin of the ribityl side-chain of riboflavin from the ribose moiety of guanosine triphosphate in Pichia guilliermondii yeast. In wild-type cells and some riboflavin-deficient mutants of P. guilliermondii GTP is transformed to the ribitylated intermediates 2,5-diamino-6-hydroxy-4-ribitylaminopyrimidine and 5-amino-2,6... | [
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PMID:30491 | Characterization of an agglutinin from human serum. | After exposure to serum, an agglutination of mitochondria from yeast, liver, heart and kidney was observed. The degree of agglutination was dependent on the ratio between the amount of serum proteins and mitochondrial protein. The serum protein which induced agglutination was bound irreversibly to the mitochondria, was... | Characterization of an agglutinin from human serum. After exposure to serum, an agglutination of mitochondria from yeast, liver, heart and kidney was observed. The degree of agglutination was dependent on the ratio between the amount of serum proteins and mitochondrial protein. The serum protein which induced agglutina... | [
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PMID:30492 | The relation between carbon monoxide binding and the conformational change of hemoglobin. | The spectral difference between normal and rapidly reacting deoxyhemoglobin (Sawicki and Gibson (1976), J. Biol Chem. 251:1533-1542) is used to study the relationship between CO binding to hemoglobin and the conformational changes to the rapidly reacting form in a combined flow-laser flash experiment. In both pH 7 phos... | The relation between carbon monoxide binding and the conformational change of hemoglobin. The spectral difference between normal and rapidly reacting deoxyhemoglobin (Sawicki and Gibson (1976), J. Biol Chem. 251:1533-1542) is used to study the relationship between CO binding to hemoglobin and the conformational changes... | [
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PMID:30493 | Bicarbonate-chloride exchange in erythrocyte suspensions. Stopped-flow pH electrode measurements. | A pH-sensitive glass electrode was used in a temperature-controlled stopped-flow rapid reaction apparatus to determine rates of pH equilibration in red cell suspensions. The apparatus requires less than 2 ml of reactants. The electrode is insensitive to pressure and flow variations, and has a response time of < 5 ms... | Bicarbonate-chloride exchange in erythrocyte suspensions. Stopped-flow pH electrode measurements. A pH-sensitive glass electrode was used in a temperature-controlled stopped-flow rapid reaction apparatus to determine rates of pH equilibration in red cell suspensions. The apparatus requires less than 2 ml of reactants. ... | [
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PMID:30497 | [Change in the concentration of nicotinamide nucleotides in rat brain and myocardium under the influence of factors inducing neurogenic dystrophy]. | The content of nicotinamide dinucleotides in the brain and myocardium induced by electrical stimulation of rats and by injection of toxic noradrenaline doses was investigated. The total level of pyridine nucleotides and of their oxidized forms proved to be decreased, and the content of triphosphopyridine nucleotides an... | [Change in the concentration of nicotinamide nucleotides in rat brain and myocardium under the influence of factors inducing neurogenic dystrophy]. The content of nicotinamide dinucleotides in the brain and myocardium induced by electrical stimulation of rats and by injection of toxic noradrenaline doses was investigat... | [
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PMID:30503 | beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. | 1 The effect of various beta-adrenoceptor blocking agents on the 5-hydroxytryptamine (5-HT)-induced hyperactivity response produced in rats by administration of tranylcypromine (10 mg/kg i.p.) followed by L-tryptophan (50 mg/kg i.p.) has been investigated. 2 (+/-)-Alprenolol, (+/-)-timolol, (+/-)-sotalol, (+/-)-pindolo... | beta-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. 1 The effect of various beta-adrenoceptor blocking agents on the 5-hydroxytryptamine (5-HT)-induced hyperactivity response produced in rats by administration of tranylcypromine (10 mg/kg i.p.) followed by L-t... | [
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PMID:30504 | Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ. | 1 Histamine has a dual action on the in situ gall bladder of the guinea-pig: a spasmogenic and a relaxant effect mediated through H1- and H2-receptor stimulation respectively. 2 The contracturant action, mimicked by 2-(2-aminoethyl) thiazole (a specific H1-receptor agonist), is blocked by mepyramine and the relaxation,... | Occurrence of H1- and H2-histamine receptors in the guinea-pig gall bladder in situ. 1 Histamine has a dual action on the in situ gall bladder of the guinea-pig: a spasmogenic and a relaxant effect mediated through H1- and H2-receptor stimulation respectively. 2 The contracturant action, mimicked by 2-(2-aminoethyl) th... | [
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PMID:30505 | Release of 3H-purines from [3H]-adenine labelled rabbit kidney following sympathetic nerve stimulation, and its inhibition by alpha-adrenoceptor blockage. | 1 Rabbit kidneys were isolated and perfused with Tyrode solution. Release of 3H-purines was studied after labeling of the adenine-nucleotide stores with [3H]adenine (more than 60% uptake during a single passage). 2 One hour after labelling the spontaneous 3H-outflow amounted to 0.1 to 0.2% of the total tissue content p... | Release of 3H-purines from [3H]-adenine labelled rabbit kidney following sympathetic nerve stimulation, and its inhibition by alpha-adrenoceptor blockage. 1 Rabbit kidneys were isolated and perfused with Tyrode solution. Release of 3H-purines was studied after labeling of the adenine-nucleotide stores with [3H]adenine ... | [
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PMID:30506 | Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline. | The alpha-adrenoceptor blocking agent, tolazoline, and the O-methylated metabolite of adrenaline, metanephrine, produced a concentration-dependent increase of tension in the smooth muscle of the cat isolated nictitating membrane. These effects were considered to be due to the activation of postsynaptic alpha-adrenocept... | Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline. The alpha-adrenoceptor blocking agent, tolazoline, and the O-methylated metabolite of adrenaline, metanephrine, produced a concentration-dependent increase of ten... | [
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PMID:30507 | Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum. | 1 The presynaptic alpha-adrenoceptors located on the terminals of the cholinergic nerves of the guineapig myenteric plexus have been characterized according to their sensitivities to alpha-adrenoceptor agonists and antagonists.2 Electrical stimulation of the cholinergic nerves supplying the longitudinal muscle of the g... | Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum. 1 The presynaptic alpha-adrenoceptors located on the terminals of the cholinergic nerves of the guineapig myenteric plexus have been characterized according to their sensitivities to alpha-ad... | [
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PMID:30510 | Radiologic manifestations of epidemic haemorrhagic fever with renal syndrome. | Epidemic haemorrhagic fever is a viral disease characterized by acute febrile onset followed by profound renal dysfunction. The endemic areas are widespread throughout the Eurasian continent and the Japanese islands. The patient with EHF usually seeks medical care as an emergency for an "acute abdomen". Consequently th... | Radiologic manifestations of epidemic haemorrhagic fever with renal syndrome. Epidemic haemorrhagic fever is a viral disease characterized by acute febrile onset followed by profound renal dysfunction. The endemic areas are widespread throughout the Eurasian continent and the Japanese islands. The patient with EHF usua... | [
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PMID:30519 | Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus. | Evidence from studies involving release, postsynaptic responses, inactivation, storage and synthesis etc. support the contention that glutamate may be the transmitter of the perforant input to the granule cells in the dentate gyrus of the hippocampus. In the present report the release of endogenous glutamate and the le... | Glutamate secretion and NAD(P)H levels during calcium-dependent depolarization of slices of the dentate gyrus. Evidence from studies involving release, postsynaptic responses, inactivation, storage and synthesis etc. support the contention that glutamate may be the transmitter of the perforant input to the granule cell... | [
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PMID:30523 | A thermodynamic analysis of the secondary transition in the spontaneous precipitation of calcium phosphate. | A thermodynamic analysis has been made of the secondary transition stage in the spontaneous precipitation of calcium phosphate following the amorphous-crystalline transformation. The first formed crystalline material has a solubility similar to that of octacalcium phosphate (OCP) and the computed thermodynamic solubili... | A thermodynamic analysis of the secondary transition in the spontaneous precipitation of calcium phosphate. A thermodynamic analysis has been made of the secondary transition stage in the spontaneous precipitation of calcium phosphate following the amorphous-crystalline transformation. The first formed crystalline mate... | [
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PMID:30524 | The role of renal nerves in the response to dipsogenic stimuli in the rat. | The effect of bilateral renal denervation on water intake and urine volume during specific thirst challenges was studied in rats. Renal denervation attenuated significantly the drinking response elicited by the administration of 30% polyethylene glycol (PG, extracellular challenge) but had no effect on the drinking res... | The role of renal nerves in the response to dipsogenic stimuli in the rat. The effect of bilateral renal denervation on water intake and urine volume during specific thirst challenges was studied in rats. Renal denervation attenuated significantly the drinking response elicited by the administration of 30% polyethylene... | [
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PMID:30526 | Pharmacological studies on the pulmonary vein of the horse. I. Effects of selected spasmogens. | Horses suffer from a respiratory condition, similar to human allergic asthma, that is characterized by severe dyspnea, wheezing, coughing, and mucus production. Mediator substances released during the allergic reaction may contract airways and pulmonary vasculature. Nothing is known of the effects of autacoids and othe... | Pharmacological studies on the pulmonary vein of the horse. I. Effects of selected spasmogens. Horses suffer from a respiratory condition, similar to human allergic asthma, that is characterized by severe dyspnea, wheezing, coughing, and mucus production. Mediator substances released during the allergic reaction may co... | [
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PMID:30527 | The ganglionic blocking properties of the cholinesterase reactivator, HS-6. | Following intravenous administration of the cholinesterase reactivator HS-6 (30 mg/kg), blood pressure fell (up to 50 mmHg) and maximal blood levels of HS-6 reached 242 microgram/ml. HS-6 attenuated the pressor response resulting from carotid occlusion and the depressor effect of vagal stimulation. Doses of HS-6 below ... | The ganglionic blocking properties of the cholinesterase reactivator, HS-6. Following intravenous administration of the cholinesterase reactivator HS-6 (30 mg/kg), blood pressure fell (up to 50 mmHg) and maximal blood levels of HS-6 reached 242 microgram/ml. HS-6 attenuated the pressor response resulting from carotid o... | [
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PMID:30528 | A presynaptic component of the action of iontophoretically applied flurazepam on feline cortical neurones. | The effect of iontophoretically applied flurazepam on the spike activity of pericruciate cortical neurones of the cat was studied. Flurazepam increased cortical inhibition produced either by local electrical stimulation (which is known to release gamma-aminobutyric acid (GABA) or by iontophoretically applied GABA. Foll... | A presynaptic component of the action of iontophoretically applied flurazepam on feline cortical neurones. The effect of iontophoretically applied flurazepam on the spike activity of pericruciate cortical neurones of the cat was studied. Flurazepam increased cortical inhibition produced either by local electrical stimu... | [
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PMID:30529 | Intracellular actions of monoamine transmitters. | Intracellular injections of noradrenaline or dopamine in spinal motoneurones of cats have a clear depolarizing action associated with particularly marked depression of spike potentials and their after-hyperpolarization, but with little slowing-down of the falling phase of the action potential. These effects are associa... | Intracellular actions of monoamine transmitters. Intracellular injections of noradrenaline or dopamine in spinal motoneurones of cats have a clear depolarizing action associated with particularly marked depression of spike potentials and their after-hyperpolarization, but with little slowing-down of the falling phase o... | [
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PMID:30530 | Purification and properties of amylase produced by a moderately halophilic Acinetobacter sp. | A moderately halophilic Acinetobacter sp., capable of producing dextrinogenic amylase, was isolated from sea-sands. Maximum enzyme production was obtained when the bacterium was cultivated aerobically in media containing 1 to 2M NaCl or 1M KCl. Two kinds of amylase, amylases I and II were purified from the culture filt... | Purification and properties of amylase produced by a moderately halophilic Acinetobacter sp. A moderately halophilic Acinetobacter sp., capable of producing dextrinogenic amylase, was isolated from sea-sands. Maximum enzyme production was obtained when the bacterium was cultivated aerobically in media containing 1 to 2... | [
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PMID:30533 | Effects of antianxiety agents on relaxation training: a preliminary investigation. | The purpose of this preliminary study was to investigate the effects of certain antianxiety agents, that is, minor tranquilizers, sedatives, and hypnotics, on relaxation training. Twelve inpatients and two outpatients were referred to group relaxation training because of tension-anxiety complaints and underwent three t... | Effects of antianxiety agents on relaxation training: a preliminary investigation. The purpose of this preliminary study was to investigate the effects of certain antianxiety agents, that is, minor tranquilizers, sedatives, and hypnotics, on relaxation training. Twelve inpatients and two outpatients were referred to gr... | [
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PMID:30534 | Therapeutic trials in tardive dyskinesia. | The search for a treatment of tardive dyskinesia has generally been guided by the putative biochemical mechanisms underlying the extrapyramidal disorders, but no markedly effective treatment has yet been found. The currently postulated mechanism in tardive dyskinesia involves namely an imbalance between the central dop... | Therapeutic trials in tardive dyskinesia. The search for a treatment of tardive dyskinesia has generally been guided by the putative biochemical mechanisms underlying the extrapyramidal disorders, but no markedly effective treatment has yet been found. The currently postulated mechanism in tardive dyskinesia involves n... | [
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PMID:30536 | Carcinoembryonic antigen (CEA) and other tumor markers in ovarian and cervical cancer. | Combinations of carcinoembryonic antigen (CEA), gamma glutamyl transpeptidase (GGT), pregnancy-associated macroglobulin (PAM) and placenta-like alkaline phosphatase (PLAP) were studied in groups of patients with ovarian and cervical cancer. In ovarian cancer, only CEA and PLAP levels appeared to reflect tumor burden an... | Carcinoembryonic antigen (CEA) and other tumor markers in ovarian and cervical cancer. Combinations of carcinoembryonic antigen (CEA), gamma glutamyl transpeptidase (GGT), pregnancy-associated macroglobulin (PAM) and placenta-like alkaline phosphatase (PLAP) were studied in groups of patients with ovarian and cervical ... | [
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PMID:30537 | Seminoma in a 12-year-old male with 46 XY/45 XO karyotype. | A pure seminoma in a 12-year-old boy with an undescended testis and 46 XY/45 XO karyotype is presented. The relationships between an undescended testis, an abnormal karyotype, dysgenetic gonads and cancer are discussed. | Seminoma in a 12-year-old male with 46 XY/45 XO karyotype. A pure seminoma in a 12-year-old boy with an undescended testis and 46 XY/45 XO karyotype is presented. The relationships between an undescended testis, an abnormal karyotype, dysgenetic gonads and cancer are discussed. | [
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PMID:30539 | Adenosine triphosphate induced change in light scattering of isolated basal bodies. | Suspensions of isolated basal bodies undergo a characteristic decrease in turbidity following their exposure to 10(-3) M ATP. Typically, turbidity changes range from 8% to 20%, depending on the preparation, with an average change of 12%. Nucleotides other than ATP did not cause a turbidity decrease. The reaction has a ... | Adenosine triphosphate induced change in light scattering of isolated basal bodies. Suspensions of isolated basal bodies undergo a characteristic decrease in turbidity following their exposure to 10(-3) M ATP. Typically, turbidity changes range from 8% to 20%, depending on the preparation, with an average change of 12%... | [
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PMID:30541 | Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro. | Following the simultaneous subcutaneous administration of CdCl2 and Na2SeO3 to rats, evidence of a Cd-Se complex was detected in plasma by gel filtration chromatography. A similar complex was found in plasma after incubation of selenite, Cd, rat erythrocytes, and plasma in vitro, and after incubation of H2Se, Cd, and p... | Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro. Following the simultaneous subcutaneous administration of CdCl2 and Na2SeO3 to rats, evidence of a Cd-Se complex was detected in plasma by gel filtration chromatography. A similar complex was found in plasma after incubation of se... | [
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PMID:30542 | Lymphocyte surface poisons: disulfides and thiolsulfonates. | Eight disulfides (I-VIII) and a thiolsulfonate (IX) were promising blocking agents of lymphocytes in graft-versus-host reactions (GvHR) without comensurate intracellular effects. The blocking effects were assayed through inhibition of the local GvHR after parental lymphocytes had been incubated with agents at suitable ... | Lymphocyte surface poisons: disulfides and thiolsulfonates. Eight disulfides (I-VIII) and a thiolsulfonate (IX) were promising blocking agents of lymphocytes in graft-versus-host reactions (GvHR) without comensurate intracellular effects. The blocking effects were assayed through inhibition of the local GvHR after pare... | [
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PMID:30543 | Correlation between tissue pH, cellular transmembrane potentials, and cellular energy metabolism during shock and during ischemia. | The relevance of two direct techniques for monitoring of cellular function during tissue hypoxia has been evaluated. Tissue pH and cellular transmembrane potentials were registered in canine skeletal muscle during intestinal exteriorization shock and during prolonged local tourniquet ischemia. The obtained pH and trans... | Correlation between tissue pH, cellular transmembrane potentials, and cellular energy metabolism during shock and during ischemia. The relevance of two direct techniques for monitoring of cellular function during tissue hypoxia has been evaluated. Tissue pH and cellular transmembrane potentials were registered in canin... | [
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PMID:30545 | Chemical characteristics of a high molecular weight renin from the renal cortex of the dog. | We found an acid extract of normal dog kidneys to contain two distinct molecular weight forms of renin-like activity. Gel filtration chromatography showed peaks of activity as estimated molecular weights of 65,000 and 41,000. The high molecular weight fraction (HMW) comprised only 1% of the total activity of the extrac... | Chemical characteristics of a high molecular weight renin from the renal cortex of the dog. We found an acid extract of normal dog kidneys to contain two distinct molecular weight forms of renin-like activity. Gel filtration chromatography showed peaks of activity as estimated molecular weights of 65,000 and 41,000. Th... | [
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PMID:30546 | Treatment of chronic idiopathic urticaria with combined H1 and H2 blockers. | Combined H1 (cyproheptadine) and H2 antihistamines (cimetidine) were tried in eight patients with chronic urticaria who were previously unresponsive to conventional anti-urticarial regimens, including type I antihistamines, hydroxyzine, ephedrine and corticosteroids. 50% of the patients responded with 90% or greater im... | Treatment of chronic idiopathic urticaria with combined H1 and H2 blockers. Combined H1 (cyproheptadine) and H2 antihistamines (cimetidine) were tried in eight patients with chronic urticaria who were previously unresponsive to conventional anti-urticarial regimens, including type I antihistamines, hydroxyzine, ephedri... | [
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PMID:30547 | Specific method for serum creatinine determination based on ion exchange chromatography and an automated alkaline picrate reaction -- a proposed reference method. | A proposed reference method for serum creatinine has been developed under the auspices of the Committee on Reference Methods and Reference Materials of the Canadian Society of Clinical Chemists. A serum ultrafiltrate at pH 2.0 is applied through a closed sample loop injection system to a short column containing cationi... | Specific method for serum creatinine determination based on ion exchange chromatography and an automated alkaline picrate reaction -- a proposed reference method. A proposed reference method for serum creatinine has been developed under the auspices of the Committee on Reference Methods and Reference Materials of the C... | [
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PMID:30549 | Multiple molecular forms of certain lysosomal enzymes separated by isoelectric focusing on cellulose acetate membranes. | Analytical isoelectric focusing on cellulose acetate membranes offers greater resolution of the enzyme pattern than does standard electrophoresis and offers numerous advantages over other support media in isoelectric focusing. A series of lysosomal enzymes, deficiencies of which cause lethal storage diseases in infants... | Multiple molecular forms of certain lysosomal enzymes separated by isoelectric focusing on cellulose acetate membranes. Analytical isoelectric focusing on cellulose acetate membranes offers greater resolution of the enzyme pattern than does standard electrophoresis and offers numerous advantages over other support medi... | [
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PMID:30550 | Measurement of serum thyroxine-binding capacity. | A new method for free thyroxine-binding sites on thyroxine-binding globulin has been described. This method for thyroxine-binding capacity has the virtues of reasonable specificity and convenience for routine use. When used with serum thyroxine levels it should be valuable in the calculation of free thyroxine and total... | Measurement of serum thyroxine-binding capacity. A new method for free thyroxine-binding sites on thyroxine-binding globulin has been described. This method for thyroxine-binding capacity has the virtues of reasonable specificity and convenience for routine use. When used with serum thyroxine levels it should be valuab... | [
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PMID:30551 | A new automated method for the determination of true creatinine in serum by means of the centrifichem centrifugal analyzer, based on Slot's principle; with special reference to low substrate concentrations. | A new automated method is proposed for the accurate determination of the true creatinine concentration in 20 microliter serum, based on the measurement of the initial rate of the decomposition reaction of the creatinine picrate complex caused by decreasing the pH. The results of this method, performed with a Centrifich... | A new automated method for the determination of true creatinine in serum by means of the centrifichem centrifugal analyzer, based on Slot's principle; with special reference to low substrate concentrations. A new automated method is proposed for the accurate determination of the true creatinine concentration in 20 micr... | [
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