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PMID:3605 | Influence of protein restriction on immune functions in NZB mice. | The influence of a low protein (6%) diet on the immunologic function of NZB mice was investigated. The low protein intake was associated with decreased weight gain in both male and female NZB mice. The mice fed the low protein diet did not develop splenomegaly, which generally occurs by 7 to 10 months of age in NZB mic... | Influence of protein restriction on immune functions in NZB mice. The influence of a low protein (6%) diet on the immunologic function of NZB mice was investigated. The low protein intake was associated with decreased weight gain in both male and female NZB mice. The mice fed the low protein diet did not develop spleno... | [
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PMID:3606 | Characterization of cells that suppress the cytotoxic activity of T lymphocytes. I. Quantitative measurement of inhibitor cells. | Target cell lysis by sensitized cytolytic T lymphocytes (CTL) may be conveniently quantitated by 51Cr release. By fitting to the formula, P (% specfic release) = 100 (1-e-Nat) one obtains alpha, the relative frequency of CTL in N lymphoid cells. Using a microassay and murine sarcoma target cells, we observed an unexpec... | Characterization of cells that suppress the cytotoxic activity of T lymphocytes. I. Quantitative measurement of inhibitor cells. Target cell lysis by sensitized cytolytic T lymphocytes (CTL) may be conveniently quantitated by 51Cr release. By fitting to the formula, P (% specfic release) = 100 (1-e-Nat) one obtains alp... | [
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PMID:3607 | IgM-mediated, T cell-independent suppression of humoral immunity. | The immunological unreactive state occurring in (T,G)-A-L nonresponder mice after secondary antigen challenge was investigated. Syngeneic IgM anti-(T,G)-A-L antibody-containing plasma, transferred at the time of the time of primary challenge, induced persistent suppression of autologous specific antibody production. Re... | IgM-mediated, T cell-independent suppression of humoral immunity. The immunological unreactive state occurring in (T,G)-A-L nonresponder mice after secondary antigen challenge was investigated. Syngeneic IgM anti-(T,G)-A-L antibody-containing plasma, transferred at the time of the time of primary challenge, induced per... | [
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PMID:3609 | Secondary IgG responses to type III pneumococcal polysaccharide. II. Different cellular requirements for induction and elicitation. | Mice primed with a thymus- (T) dependent form of Type III pneumococcal polysaccharide (S3), i.e., S3 coupled to erythrocytes (S3-RBC) produce S3-specific IgG antibody after secondary challenge with either S3 or S3-RBC. The production of IgG antibody by mice challenged with S3 was shown to be T independent since seconda... | Secondary IgG responses to type III pneumococcal polysaccharide. II. Different cellular requirements for induction and elicitation. Mice primed with a thymus- (T) dependent form of Type III pneumococcal polysaccharide (S3), i.e., S3 coupled to erythrocytes (S3-RBC) produce S3-specific IgG antibody after secondary chall... | [
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PMID:3610 | The effect of Bordetella pertussis on the antibody response in mice to type III pneumococcal polysaccharide. | The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibo... | The effect of Bordetella pertussis on the antibody response in mice to type III pneumococcal polysaccharide. The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when ... | [
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PMID:3611 | Immunology of DNA. I. The influence of reaction conditions on the Farr assay as used for the detection of anti-ds DNA. | The sensitivity and the specificity of the Farr assay for the detection of antibodies to double stranded (ds) DNA depends very much on the reaction conditions. The interaction between ds DNA and anti-ds DNA is inhibited when ionic strength and pH are increased. ds DNA is bound by normal sera at ionic strength lower tha... | Immunology of DNA. I. The influence of reaction conditions on the Farr assay as used for the detection of anti-ds DNA. The sensitivity and the specificity of the Farr assay for the detection of antibodies to double stranded (ds) DNA depends very much on the reaction conditions. The interaction between ds DNA and anti-d... | [
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PMID:3612 | A Doppler assay for the antigen--antibody reaction. | The specific combination of antigen with antibody was detected rapidly and with high sensitivity by an assay based on particle electrophoresis and laser light scattering. Antibody attachment to dilute suspensions of submicroscopic polystyrene spheres coated with antigen was detected as changes in the Doppler shift of s... | A Doppler assay for the antigen--antibody reaction. The specific combination of antigen with antibody was detected rapidly and with high sensitivity by an assay based on particle electrophoresis and laser light scattering. Antibody attachment to dilute suspensions of submicroscopic polystyrene spheres coated with antig... | [
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PMID:3613 | California arbovirus (La Crosse) infections. III. Epidemiology of California encephalitis in Minnesota. | Mosquitoes (eggs, larvae, and adults), small woodland animals, and residents of an area where California encephalitis is endemic were studied to elucidate the host-vector cycle of La Crosse virus. Elementary schoolchildren from surrounding communities and gray squirrels from another area were tested to compare the prev... | California arbovirus (La Crosse) infections. III. Epidemiology of California encephalitis in Minnesota. Mosquitoes (eggs, larvae, and adults), small woodland animals, and residents of an area where California encephalitis is endemic were studied to elucidate the host-vector cycle of La Crosse virus. Elementary schoolch... | [
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PMID:3614 | Characterization of fatty acid desaturase activity in rat lung microsomes. | Preparations of rat lung microsomes containing 0.030-0.050 nmole of cytochromes P-450 and b5 per mg microsomal protein have been observed to contain significant levels of fatty acid desaturase activity. Both stearoyl CoA and palmitoyl CoA are desaturated to their monounsaturated analogues, oleic acid and palmitoleic ac... | Characterization of fatty acid desaturase activity in rat lung microsomes. Preparations of rat lung microsomes containing 0.030-0.050 nmole of cytochromes P-450 and b5 per mg microsomal protein have been observed to contain significant levels of fatty acid desaturase activity. Both stearoyl CoA and palmitoyl CoA are de... | [
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PMID:3615 | Effect of unilateral and bilateral castration and cryptorchidism on serum gonadotrophins in the rat. | The effects of unilateral and bilateral cryptorchidism and castration on serum concentrations of testosterone, FSH and LH in adult male rats were examined. The results provide no evidence for compensatory growth or development of the remaining scrotal testes up to 32 days after unilateral castration, although the scrot... | Effect of unilateral and bilateral castration and cryptorchidism on serum gonadotrophins in the rat. The effects of unilateral and bilateral cryptorchidism and castration on serum concentrations of testosterone, FSH and LH in adult male rats were examined. The results provide no evidence for compensatory growth or deve... | [
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PMID:3616 | Further evidence for histamine facilitating oestrogen action in the uterus. | The effect of doses of estradiol ranging from 0-0125 to 1-6 mug on the uterine weight of the spayed rat was studied 24 h after a single s.c. injection of the hormone. The lowest dose inducing a significant increase in uterine weight was 0-32 mug. When histamine dihydrochloride (50 mg) was simultaneously injected with t... | Further evidence for histamine facilitating oestrogen action in the uterus. The effect of doses of estradiol ranging from 0-0125 to 1-6 mug on the uterine weight of the spayed rat was studied 24 h after a single s.c. injection of the hormone. The lowest dose inducing a significant increase in uterine weight was 0-32 mu... | [
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PMID:3617 | Prolactin stimulation test with perphenazine: an evaluation of plasma prolactin levels and pituitary secretory activity in the rat. | Many investigations of the regulation of prolactin synthesis and release are based on single plasma prolactin determinations. The purpose of the present experiment was to ascertain whether groups of rats (i.e. young or adult, male or female animals, being either intact, gonadectomized or gonadectomized and treated with... | Prolactin stimulation test with perphenazine: an evaluation of plasma prolactin levels and pituitary secretory activity in the rat. Many investigations of the regulation of prolactin synthesis and release are based on single plasma prolactin determinations. The purpose of the present experiment was to ascertain whether... | [
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PMID:3618 | Activation and desensitization of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response. | The secretion of vasoactive amines from rabbit platelets induced by the platelet-activating factor (PAF) derived from IgE-sensitized rabbit basophils, was examined. The secretion required calcium has previously been shown to be noncytotoxic and was optimal in both rate and extent at 37 degrees C and pH 7.2. Different t... | Activation and desensitization of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response. The secretion of vasoactive amines from rabbit platelets induced by the platelet-activating factor (PAF) derived from IgE-sensitized rabbit basophils, was ... | [
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PMID:3619 | Activation of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. II. The role of serine proteases, cyclic nucleotides, and contractile elements in PAF-induced secretion. | Secretion of serotonin from platelets induced by platelet-activating factor (PAF) derived from antigen-stimulated, IgE-sensitized rabbit basophils was studied to further characterize the biochemical requirements. Inhibition of secretion with diisopropylphosphofluoridate (DFP) was observed if the DFP was present during ... | Activation of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. II. The role of serine proteases, cyclic nucleotides, and contractile elements in PAF-induced secretion. Secretion of serotonin from platelets induced by platelet-activating factor (PAF) derived from antigen-stimulated, I... | [
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PMID:3620 | Acid hydrolases in leukocytes and platelets of normal subjects and in patients with Gaucher's and Fabry's disease. | Lymphocytes, monocytes, neutrophilic granulocytes and platelets were each separated to greater than 95% purity from six normal subjects, three patients with Gaucher's disease, two heterozygotes for Gaucher's disease, and one patient with Fabry's disease. Activities of the following acid hydrolases were determined: "aci... | Acid hydrolases in leukocytes and platelets of normal subjects and in patients with Gaucher's and Fabry's disease. Lymphocytes, monocytes, neutrophilic granulocytes and platelets were each separated to greater than 95% purity from six normal subjects, three patients with Gaucher's disease, two heterozygotes for Gaucher... | [
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PMID:3621 | Regulation of the oxidative NADP-enzyme tissue levels in Drosophila melanogaster. I. Modulation by dietary carbohydrate and lipid. | Wild-type third instar larvae of Drosophilia melanogaster fed a casein-sucrose synthetic diet supplemented with phosphatidylcholine (4 mg/ml) possessed 33% more tissue lipid and a modified fatty acid profile compared to larvae fed a fat free-sucrose diet. The rates of lipid synthesis and pentose shunt activity were 2.1... | Regulation of the oxidative NADP-enzyme tissue levels in Drosophila melanogaster. I. Modulation by dietary carbohydrate and lipid. Wild-type third instar larvae of Drosophilia melanogaster fed a casein-sucrose synthetic diet supplemented with phosphatidylcholine (4 mg/ml) possessed 33% more tissue lipid and a modified ... | [
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PMID:3622 | Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans. | Genetic analysis of 119 acetate non-utilizing (acu) mutants in Aspergillus nidulans revealed ten new loci affecting acetate metabolism in addition to the three previously recognized on the basis of resistance to fluoroacetate and acetate non-utilization. The enzyme lesions associated with mutations at seven of the acu ... | Analysis of acetate non-utilizing (acu) mutants in Aspergillus nidulans. Genetic analysis of 119 acetate non-utilizing (acu) mutants in Aspergillus nidulans revealed ten new loci affecting acetate metabolism in addition to the three previously recognized on the basis of resistance to fluoroacetate and acetate non-utili... | [
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PMID:3623 | Predicting individual responses to drug treatment in schizophrenia: a test dose model. | The literature and the findings from the Camarillo Schizophrenia Research Project reported in this paper indicate that a satisfactory method for predicting the response of an individual schizophrenic patient to antipsychotic drugs has yet to be devised. A test dose procedure is described which offers promise of a pract... | Predicting individual responses to drug treatment in schizophrenia: a test dose model. The literature and the findings from the Camarillo Schizophrenia Research Project reported in this paper indicate that a satisfactory method for predicting the response of an individual schizophrenic patient to antipsychotic drugs ha... | [
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PMID:3624 | On the bimodality of the distribution of electrodermal orienting responses in schizophrenic patients. | Data are presented from four of the author's studies on the electrodermal orienting responss which fail to confirm the findings of Gruzelier and Venables of a markedly bimodal distribution of ORs in schizophrenic populations. A review of the findings of other earlier studies, none of which confirm the bimodal hypothesi... | On the bimodality of the distribution of electrodermal orienting responses in schizophrenic patients. Data are presented from four of the author's studies on the electrodermal orienting responss which fail to confirm the findings of Gruzelier and Venables of a markedly bimodal distribution of ORs in schizophrenic popul... | [
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PMID:3632 | Sudden hemorrhage in metastatic thyroid carcinoma of the brain during treatment with iodine-131. | A patient with papillary--follicular carcinoma of the thyroid, with metastases to the lungs, skeleton, and brain was treated 5 weeks after thyroidectomy with 135 mCi of 131I. Although preliminary studies with 1 mCi had not shown any iodine uptake by the brain metastasis, this lesion showed intense concentration at the ... | Sudden hemorrhage in metastatic thyroid carcinoma of the brain during treatment with iodine-131. A patient with papillary--follicular carcinoma of the thyroid, with metastases to the lungs, skeleton, and brain was treated 5 weeks after thyroidectomy with 135 mCi of 131I. Although preliminary studies with 1 mCi had not ... | [
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PMID:3635 | Concentrations of bacteria in cerebrospinal fluid of patients with bacterial meningitis. | Concentrations of bacteria in cerebrospinal fluid ranged from 4.5 X 10(3) to 3 X 10(8) colony-forming units/ml in 27 patients with bacterial meningitis before antibiotic therapy and from 4 X 10(1) to 1.4 X 10(6) CFU/ml in four patients after one to two days of antibiotic therapy. All patients with persistent positive c... | Concentrations of bacteria in cerebrospinal fluid of patients with bacterial meningitis. Concentrations of bacteria in cerebrospinal fluid ranged from 4.5 X 10(3) to 3 X 10(8) colony-forming units/ml in 27 patients with bacterial meningitis before antibiotic therapy and from 4 X 10(1) to 1.4 X 10(6) CFU/ml in four pati... | [
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PMID:3638 | Quantitative determination of resorcinol in presence of phenol. | A simple and accurate method for the quantitative determination of resorcinol in the presence of phenol is reported. The method is based on the formation of indophenol by reacting resorcinol with 2, 6-dibromoquinone-4-chlorimide. The concentration of indophenol can be measured spectrophotometrically. This method is rec... | Quantitative determination of resorcinol in presence of phenol. A simple and accurate method for the quantitative determination of resorcinol in the presence of phenol is reported. The method is based on the formation of indophenol by reacting resorcinol with 2, 6-dibromoquinone-4-chlorimide. The concentration of indop... | [
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PMID:3639 | Oil-water distribution of p-alkylpyridines. | The distribution of a homologous series of p-alkylpyridines between water and six organic solvents with varying degrees of polarity was investigated. The distribution coefficients were considered as reflections of the strength of net interactions involved in the solvents. The order was chloroform greater than octanol g... | Oil-water distribution of p-alkylpyridines. The distribution of a homologous series of p-alkylpyridines between water and six organic solvents with varying degrees of polarity was investigated. The distribution coefficients were considered as reflections of the strength of net interactions involved in the solvents. The... | [
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PMID:3640 | Neurogenic influences of bilateral adrenalectomy on monoamine oxidase. | Bilateral adrenalectomy (10 days) increased the monoamine oxidase activity of the rat heart, vas deferens, spleen, superior cervical ganglion, and hypothalamus but not that of the rest of the brain, kidney, and liver. Experiments were made to determine whether the increased activity was due to neurogenic influences and... | Neurogenic influences of bilateral adrenalectomy on monoamine oxidase. Bilateral adrenalectomy (10 days) increased the monoamine oxidase activity of the rat heart, vas deferens, spleen, superior cervical ganglion, and hypothalamus but not that of the rest of the brain, kidney, and liver. Experiments were made to determ... | [
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PMID:3641 | Binding study of tetracyclines to human serum albumin using difference spectrophotometry. | The binding of several tetracyclines to human serum albumin was studied using difference spectrophotometry and a spectrophotometric probe, 2-(4'-hydroxybenzeneazo)benzoic acid. Difference spectra observed for the interaction between the probe and human serum albumin were similar to probe-bovine serum albumin spectra bu... | Binding study of tetracyclines to human serum albumin using difference spectrophotometry. The binding of several tetracyclines to human serum albumin was studied using difference spectrophotometry and a spectrophotometric probe, 2-(4'-hydroxybenzeneazo)benzoic acid. Difference spectra observed for the interaction betwe... | [
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PMID:3642 | Fluorescence of hydralazine in concentrated sulfuric acid. | Hydralazine shows intense fluorescence at 353 nm in concentrated sulfuric acid when excited at 320 nm. This fluorescence can be utilized for the quantitative analysis of the drug in dosage forms. | Fluorescence of hydralazine in concentrated sulfuric acid. Hydralazine shows intense fluorescence at 353 nm in concentrated sulfuric acid when excited at 320 nm. This fluorescence can be utilized for the quantitative analysis of the drug in dosage forms. | [
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PMID:3643 | The antiarrhythmic and cardiovascular properties of 1-dimethyl isopropylamino-3-(2-phenylphenoxy)-propan-2-ol chloride, UM-424. | The quarternary ammonium compound, UM-424 [1-dimethyl isopropylamino-3-(2-phenylphenoxy)-propan-2-ol chloride], was evaluated for its antiarrhythmic and hemodynamic effects. UM-424 converted ouabain-induced ventricular tachycardia in the anesthetized dog when administered in an average dose of 4.6 mg/kg i.v. Pretreatme... | The antiarrhythmic and cardiovascular properties of 1-dimethyl isopropylamino-3-(2-phenylphenoxy)-propan-2-ol chloride, UM-424. The quarternary ammonium compound, UM-424 [1-dimethyl isopropylamino-3-(2-phenylphenoxy)-propan-2-ol chloride], was evaluated for its antiarrhythmic and hemodynamic effects. UM-424 converted o... | [
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PMID:3644 | Acid secretion by guinea-pig isolated stomach. | An isolated stomach preparation from the guinea-pig is described. 2. Both histamine acid phosphate (1-4 mug/ml.) and theophylline hydrate (0-2-3-2 mg/ml.) separately stimulated hydrochloric acid, HCl, secretion from the guinea-pig stomach preparation. A linear dose-response relationship was obtained for theophylline. 3... | Acid secretion by guinea-pig isolated stomach. An isolated stomach preparation from the guinea-pig is described. 2. Both histamine acid phosphate (1-4 mug/ml.) and theophylline hydrate (0-2-3-2 mg/ml.) separately stimulated hydrochloric acid, HCl, secretion from the guinea-pig stomach preparation. A linear dose-respons... | [
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PMID:3645 | Two components of the calcium current in the egg cell membrane of the tunicate. | The Ca current of the egg cell membrane of a certain tunicate, Halocynthia roretzi Drasche, was studied by the voltage-clamp technique. 2. The Ca current in the standard artificial sea water (ASW) was produced at the critical membrane potential of -10 mV after inactivating the Na current by conditioning depolarization,... | Two components of the calcium current in the egg cell membrane of the tunicate. The Ca current of the egg cell membrane of a certain tunicate, Halocynthia roretzi Drasche, was studied by the voltage-clamp technique. 2. The Ca current in the standard artificial sea water (ASW) was produced at the critical membrane poten... | [
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PMID:3646 | Oestrogenic sensitivity of rat uterine secretion. | Ovariectomized adult rats with closed uteri were treated for 7 days with different oral and s..c. doses of oestradiol, oestrone, oestriol and ethinyl oestradiol. All treatments elicited the production of uterine fluid and the potencies of oestrogens were related to the amount of fluid secreted. Ethinyl oestradiol and o... | Oestrogenic sensitivity of rat uterine secretion. Ovariectomized adult rats with closed uteri were treated for 7 days with different oral and s..c. doses of oestradiol, oestrone, oestriol and ethinyl oestradiol. All treatments elicited the production of uterine fluid and the potencies of oestrogens were related to the ... | [
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PMID:3647 | A new series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols. | A series of 1-(2-acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols has been synthesized and examined for beta-receptor blocking and antiarrhythmic activity. Several of these compounds are more than 20 times as active in blocking cardiac beta-receptors than vascular beta-receptors when given intravenously to anesthe... | A new series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols. A series of 1-(2-acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols has been synthesized and examined for beta-receptor blocking and antiarrhythmic activity. Several of these compo... | [
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PMID:3648 | Teaching interviewing for pediatrics. | This paper describes a structured course for teaching interviewing which focuses on the interaction between the patient and the practitioner. Three main areas of learning were selected because of their universal application: relationship, communication, and feelings. Theoretical material is related to positive and nega... | Teaching interviewing for pediatrics. This paper describes a structured course for teaching interviewing which focuses on the interaction between the patient and the practitioner. Three main areas of learning were selected because of their universal application: relationship, communication, and feelings. Theoretical ma... | [
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PMID:3652 | Effect of calcium on the membrane potential of Amphiuma red cells. | An increase in extracellular Ca concentration causes the membrane of giant red cells of the salamander, Amphiuma means, to undergo a marked, transient hyperpolarization. This hyperpolarization is caused by an increase in K permeability of the membrane as judged from the K sensitivity of the membrane potential and from ... | Effect of calcium on the membrane potential of Amphiuma red cells. An increase in extracellular Ca concentration causes the membrane of giant red cells of the salamander, Amphiuma means, to undergo a marked, transient hyperpolarization. This hyperpolarization is caused by an increase in K permeability of the membrane a... | [
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PMID:3653 | Transitory postnatal hemolysis of calf red cells by amino acids. | Among the amino acids which can be solubilized to give a concentration of 300 mm at near physiological pH, histidine and proline caused a complete hemolysis of newborn calf but not of adult cow red cells within 20 to 30 minutes at 38 degrees C. While hydroxyproline, valine, and serine resulted in a partial lysis of cal... | Transitory postnatal hemolysis of calf red cells by amino acids. Among the amino acids which can be solubilized to give a concentration of 300 mm at near physiological pH, histidine and proline caused a complete hemolysis of newborn calf but not of adult cow red cells within 20 to 30 minutes at 38 degrees C. While hydr... | [
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PMID:3650 | ATP synthesis driven by a protonmotive force in Streptococcus lactis. | An electrochemical potential difference for hydrogen ions ( a protonmotive force) was artifically imposed across the membrane of the anaerobic bacterium Streptococcus lactis. When cells were exposed to the ionophore, valinomycin, the electrical gradient was established by a potassium diffusion potential. A chemical gra... | ATP synthesis driven by a protonmotive force in Streptococcus lactis. An electrochemical potential difference for hydrogen ions ( a protonmotive force) was artifically imposed across the membrane of the anaerobic bacterium Streptococcus lactis. When cells were exposed to the ionophore, valinomycin, the electrical gradi... | [
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PMID:3651 | Effect of local anesthetics on chloride transport in erythrocytes. | The self-exchange of chloride isotopes across the human erythrocyte membrane was inhibited by tetracaine, benzocaine, and lidocaine. The inhibition by tetracaine was increased at higher pH values, but was not exclusively due to the uncharged form of tetracaine. The inhibition was effective within 5 seconds, was reversi... | Effect of local anesthetics on chloride transport in erythrocytes. The self-exchange of chloride isotopes across the human erythrocyte membrane was inhibited by tetracaine, benzocaine, and lidocaine. The inhibition by tetracaine was increased at higher pH values, but was not exclusively due to the uncharged form of tet... | [
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PMID:3660 | Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas. | The biochemical properties of cyclic nucleotide phosphodiesterases in a nonmetastasizing and a spontaneously metastasizing rat mammary carcinoma were compared. The phosphooiesterases in both tumors had a pH optimum of around 8.0 and preferentially hydrolysed cyclic purine nucleotides. The rate of hydrolysis of purine n... | Biochemical properties of cyclic nucleotide phosphodiesterase in metastasizing and nonmetastasizing rat mammary carcinomas. The biochemical properties of cyclic nucleotide phosphodiesterases in a nonmetastasizing and a spontaneously metastasizing rat mammary carcinoma were compared. The phosphooiesterases in both tumor... | [
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PMID:3661 | Hybrid-versus-parental strain reaction. III. Comparative mortality in parental strain mice of the H-2k genotype. | Lethally irradiated parental strain male and female mice were inoculated with marrow from reciprocal hybrid donors of the same sex. Hybrid cells homozygous for the H-2k genotype could recognize the quantitatively greater antigenicity of the parental strain CBA male recipients only. The more severe reaction occurred whe... | Hybrid-versus-parental strain reaction. III. Comparative mortality in parental strain mice of the H-2k genotype. Lethally irradiated parental strain male and female mice were inoculated with marrow from reciprocal hybrid donors of the same sex. Hybrid cells homozygous for the H-2k genotype could recognize the quantitat... | [
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PMID:3662 | Cryptorchidism, hernia, and cancer of the testis. | Risk of cancer of the testis was related to nondescent and hernia in a comparison of 596 testicular cancer patients and 602 unaffected men who had been in active service in the U.S. Army between 1950 and 1970. Medical histories were obtained from routine service records. Undescended testis was associated with a testicu... | Cryptorchidism, hernia, and cancer of the testis. Risk of cancer of the testis was related to nondescent and hernia in a comparison of 596 testicular cancer patients and 602 unaffected men who had been in active service in the U.S. Army between 1950 and 1970. Medical histories were obtained from routine service records... | [
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PMID:3664 | Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. | The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in PAP and a decrease in LAP. This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to demonstrated multiple pulmonary microemboli. Hypoxemia developed in only four ... | Hemodynamic and respiratory responses of conscious swine to E. coli endotoxin. The injection of a sublethal bolus of E. coli into conscious swine produces an early increase in PAP and a decrease in LAP. This hemodynamic effect may be secondary to the pulmonary venous constriction seen in other species, or may relate to... | [
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PMID:3665 | Isoaccepting species of serine tRNA coded by bacteriophage T5sto. | By aminoacyl-tRNA-DNA hybridization and chromatographic analysis, evidence was provided that the bacteriophage T5stO codes for two tRNAser species. Trinucleotide- or polynucleotide-stimulated binding experiments assigned the codons UCC or UCU to these two tRNAser species. They also suggested that the synthesis of these... | Isoaccepting species of serine tRNA coded by bacteriophage T5sto. By aminoacyl-tRNA-DNA hybridization and chromatographic analysis, evidence was provided that the bacteriophage T5stO codes for two tRNAser species. Trinucleotide- or polynucleotide-stimulated binding experiments assigned the codons UCC or UCU to these tw... | [
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PMID:3666 | Purification and characterization of mouse interferon with novel affinity sorbents. | Several novel selective sorbents for mouse interferon are described that exploit the hydrophobic property and glycoprotein nature of this molecule. Low-molecular-weight ligands (hydrocarbons) and high-molecular-weight ligands (bovine serum albumin) immobilized on agarose bind selectively mouse L-cell interferon. The hi... | Purification and characterization of mouse interferon with novel affinity sorbents. Several novel selective sorbents for mouse interferon are described that exploit the hydrophobic property and glycoprotein nature of this molecule. Low-molecular-weight ligands (hydrocarbons) and high-molecular-weight ligands (bovine se... | [
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PMID:3667 | Induction of prophage SPO2 in Bacillus subtilis: isolation of excised prophage DNA as a covently closed circle. | Bacillus subtilis tryC2, thyA, thyB, lysogenic for the phage DNA polymerase negative mutant SPO2 susL244, was induced under conditions preventing phage and bacterial DNA synthesis. The biological activity of DNA from induced cells and from uninduced controls was assayed by transformation and transfection, respectively.... | Induction of prophage SPO2 in Bacillus subtilis: isolation of excised prophage DNA as a covently closed circle. Bacillus subtilis tryC2, thyA, thyB, lysogenic for the phage DNA polymerase negative mutant SPO2 susL244, was induced under conditions preventing phage and bacterial DNA synthesis. The biological activity of ... | [
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PMID:3668 | Escherichia coli capsule bacteriophages. VIII. Fragments of bacteriophage 28-1. | As described previously, a host capsule depolymerase activity is associated with the particles of Escherichia coli capsule bacteriophage 28-1. This is a large virus with a long, contractile tail terminating in a base plate with spikes. In the present work, isolated virions were exposed to a variety of dissociative reag... | Escherichia coli capsule bacteriophages. VIII. Fragments of bacteriophage 28-1. As described previously, a host capsule depolymerase activity is associated with the particles of Escherichia coli capsule bacteriophage 28-1. This is a large virus with a long, contractile tail terminating in a base plate with spikes. In t... | [
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PMID:3674 | Studies on mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (I). Beta-blocking action of mescaline and its derivatives. | In order to clarify whether or not trimetoquinol (TMQ) and isoproterenol (ISO) interact with the same receptor, the pA2 values of propranolol (PR) and certain trimethoxybenzene derivatives were measured, using isolated guinea pig tracheal chains. Each of PR, mescaline (MES) and its derivatives gave almost the same pA2 ... | Studies on mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (I). Beta-blocking action of mescaline and its derivatives. In order to clarify whether or not trimetoquinol (TMQ) and isoproterenol (ISO) interact with the same receptor, the pA2 values of propranolol (PR) and certain trimethoxyben... | [
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PMID:3675 | Regulation of tyrosine hydroxylase activity by prostaglandin E1 in guinea pig adrenal gland. | The action of prostaglandin E1 on tyrosine hydroxylase activity in adrenal slices of guinea pig was studied. The activity of tyrosine hydroxylase and was decreased by the incubation of adrenal slices with prostaglandin E1 at concentrations beyond 2 mug per ml for 2 hours. The activity of tyrosine hydroxylase was stimul... | Regulation of tyrosine hydroxylase activity by prostaglandin E1 in guinea pig adrenal gland. The action of prostaglandin E1 on tyrosine hydroxylase activity in adrenal slices of guinea pig was studied. The activity of tyrosine hydroxylase and was decreased by the incubation of adrenal slices with prostaglandin E1 at co... | [
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PMID:3681 | [The role of HCO3- ATPase in H+ /HCO3-Secretion (author's transl)]. | Active buffer transport, e.g. H+ -secretion by stomach and kidney and HCO3--secretion by pancreas and salivary glands, is linked with the presence of a HCO3-stimulated ATP-Phosphohydrolase. In contrast to (Na+ -k+)-ATPase which is considered to be equivalent to the Na+ pump, the HCO3--ATPase requires only one ion for a... | [The role of HCO3- ATPase in H+ /HCO3-Secretion (author's transl)]. Active buffer transport, e.g. H+ -secretion by stomach and kidney and HCO3--secretion by pancreas and salivary glands, is linked with the presence of a HCO3-stimulated ATP-Phosphohydrolase. In contrast to (Na+ -k+)-ATPase which is considered to be equi... | [
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PMID:3684 | [Interlocking medullary nailing. Indications, technic with a new guiding instrument. Analysis of the 1st 50 operations]. | After a review of Küntsher's intramedullary nailing, the author resumed the informations about the interlocking medullary nail and its technique. A new device, as a guide instrument for easier application of the transverse bolts was constructed on the basis of authors concept. Using the new technique and guide instrume... | [Interlocking medullary nailing. Indications, technic with a new guiding instrument. Analysis of the 1st 50 operations]. After a review of Küntsher's intramedullary nailing, the author resumed the informations about the interlocking medullary nail and its technique. A new device, as a guide instrument for easier applic... | [
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PMID:3682 | [Tissue specific inhibition of lymphocyte proliferation by spleen extract (lymphocyte chalone) (author's transl)]. | Aqueous spleen extracts were purified using acetone precipitation, membrane filtration, affinity chromatography, and dialysis. These extracts were able to inhibit thymidine incorporation into lymphoid cells (MKT-CH and PHA-stimulated lymphocyte cultures). They did not influence non lymphoid tissue (melanoma cells Mel E... | [Tissue specific inhibition of lymphocyte proliferation by spleen extract (lymphocyte chalone) (author's transl)]. Aqueous spleen extracts were purified using acetone precipitation, membrane filtration, affinity chromatography, and dialysis. These extracts were able to inhibit thymidine incorporation into lymphoid cell... | [
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PMID:3685 | [Supporting role of the fibula in tibial fractures]. | The possibilities of the supporting effect of the fibula and of its preclusion are discussed. The indication of the fibulotomia is dealt with. According to the authors' standpoint in the case of the anatomical reposition of the tibial fracture and after its staple synthesis the supporting effect of the fibula is not be... | [Supporting role of the fibula in tibial fractures]. The possibilities of the supporting effect of the fibula and of its preclusion are discussed. The indication of the fibulotomia is dealt with. According to the authors' standpoint in the case of the anatomical reposition of the tibial fracture and after its staple sy... | [
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PMID:3686 | [Clinical aspects and pathology of traumatic lesions of the optic nerve]. | The cause of the unilateral complete blindness (amaurosis traumatica) occurring in the case of closed cranial injury has been sought for in the optic nerve canal (canalis opticus syndrome). For the decompression of the optic nerve surgical approach has been performed in several institutes and by various neurosurgeons. ... | [Clinical aspects and pathology of traumatic lesions of the optic nerve]. The cause of the unilateral complete blindness (amaurosis traumatica) occurring in the case of closed cranial injury has been sought for in the optic nerve canal (canalis opticus syndrome). For the decompression of the optic nerve surgical approa... | [
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PMID:3687 | [Preservation of crushed extremities]. | For the conservation of crushed extremities all achievements of up-to-date traumatology are to be used. The impairement of the seriously crushed extremity displays a certain similarity to the polytraumatism involving the whole organism. This is to be taken into consideration in the surgical treatment. Conserving the vi... | [Preservation of crushed extremities]. For the conservation of crushed extremities all achievements of up-to-date traumatology are to be used. The impairement of the seriously crushed extremity displays a certain similarity to the polytraumatism involving the whole organism. This is to be taken into consideration in th... | [
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PMID:3689 | [Experience with the management of subtalar dislocation]. | In 10 and 3 years resp., material of two surgical departments - with great material - 10 cases of luxation - without fracture - occurred in the subtaler joint have been treated. All 10 patients suffered covered, subtaler dislocations. After conservative treatment all 10 patients recovered and are back at work. | [Experience with the management of subtalar dislocation]. In 10 and 3 years resp., material of two surgical departments - with great material - 10 cases of luxation - without fracture - occurred in the subtaler joint have been treated. All 10 patients suffered covered, subtaler dislocations. After conservative treatmen... | [
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PMID:3690 | [Treatment of contracture of the finger joints by capsulectomy and spring-splints]. | The treatment performed in 84 cases of contracted PIP articulations is reported, -in 50 cases the treatment has been carried out with spring-actuated splint and in 34 cases with capsulectomy. It has been found by the authors that the results of the physico-therapeutic treatment used so-far may be still more improved, -... | [Treatment of contracture of the finger joints by capsulectomy and spring-splints]. The treatment performed in 84 cases of contracted PIP articulations is reported, -in 50 cases the treatment has been carried out with spring-actuated splint and in 34 cases with capsulectomy. It has been found by the authors that the re... | [
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PMID:3691 | [Experimental single-stage reconstruction of the tendon sheath and flexor tendon (free tendon graft, using a vein for sheath on the flexor tendon in dogs)]. | In dog experiments the flexor tendons of the 2nd toe together with their tendon sheaths have been extirpated by the authors. Then on the place of the tendon sheath complex-resembling the human hand's "no man's land" -for the substitution of the tendon sheath-free inautotransplants with long vein-segments have been graf... | [Experimental single-stage reconstruction of the tendon sheath and flexor tendon (free tendon graft, using a vein for sheath on the flexor tendon in dogs)]. In dog experiments the flexor tendons of the 2nd toe together with their tendon sheaths have been extirpated by the authors. Then on the place of the tendon sheath... | [
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PMID:3692 | [Reconstruction of the injured flexor tendon in the proximal half of the "no man's land" by a modified method (tendon sheath reconstruction using a vein graft)]. | On the basis of long years' experiences the "no man's land" has been divided by the author into 2 parts: the proximal and the distal part. For the treatment of the flexor tendon lesions occurred in the distal part of the author advocates his method already published: in the "tendon sheath" formed from the vein its "bri... | [Reconstruction of the injured flexor tendon in the proximal half of the "no man's land" by a modified method (tendon sheath reconstruction using a vein graft)]. On the basis of long years' experiences the "no man's land" has been divided by the author into 2 parts: the proximal and the distal part. For the treatment o... | [
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PMID:3693 | [Isolated luxation of the trapezium bone]. | The luxation of the os trapezium without fracture - a very rare lesion - is reported. This is the first publication in the Hungarian literature of this sort. Proper diagnosis was established after the patient's admission. Covered reduction of the luxation was made, and the luxated bone was fixed by percutaneous wiring ... | [Isolated luxation of the trapezium bone]. The luxation of the os trapezium without fracture - a very rare lesion - is reported. This is the first publication in the Hungarian literature of this sort. Proper diagnosis was established after the patient's admission. Covered reduction of the luxation was made, and the lux... | [
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PMID:3694 | [Amputation and rehabilitation]. | Amputation is maybe the oldest and most frequent surgical intervention. After the review of the concept of rehabilitation, its methods and the improvement of the rehabilitation technique the earling opinions in respect of the height of the amputation, the surgical technique and the post-operative treatment - the use of... | [Amputation and rehabilitation]. Amputation is maybe the oldest and most frequent surgical intervention. After the review of the concept of rehabilitation, its methods and the improvement of the rehabilitation technique the earling opinions in respect of the height of the amputation, the surgical technique and the post... | [
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PMID:3695 | [Special care of injured patients after returning to work]. | The changes in the type of injury, as well as in the treatment, and the consequences observed during the check-up of the injured patients set the problem of the prolonged care of the patients after the articular fractions of the lower extremity, amputation, arthroplasty, and severe lesions of the hand. Systematic obser... | [Special care of injured patients after returning to work]. The changes in the type of injury, as well as in the treatment, and the consequences observed during the check-up of the injured patients set the problem of the prolonged care of the patients after the articular fractions of the lower extremity, amputation, ar... | [
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PMID:3697 | Chemical injuries of the upper extremity. | The prompt recognition and management (Tables 8-1 and 8-2) of chemical burns of the upper extremity may prevent injury to the deep structures of the hand and may make the difference between satisfactory rehabilitation and crippling deformities. Immediate irrigation with water is the single most important treatment that... | Chemical injuries of the upper extremity. The prompt recognition and management (Tables 8-1 and 8-2) of chemical burns of the upper extremity may prevent injury to the deep structures of the hand and may make the difference between satisfactory rehabilitation and crippling deformities. Immediate irrigation with water i... | [
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PMID:3698 | Intraspecific variations in the hemolymph of Biomphalaria glabrata, a snail host of Schistosoma mansoni. | An attempt was made to characterize the hemolymph of Biomphalaria glabrata with reference to "normal" intra-specific variation, i.e., both inter- and intra-strain differences. Total protein concentration, per cent hemoglobin, pH, and osmolarity were studied. Seven geographic strains of B, glabrata were examined. In add... | Intraspecific variations in the hemolymph of Biomphalaria glabrata, a snail host of Schistosoma mansoni. An attempt was made to characterize the hemolymph of Biomphalaria glabrata with reference to "normal" intra-specific variation, i.e., both inter- and intra-strain differences. Total protein concentration, per cent h... | [
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PMID:3720 | [Relevance of biochemistry in diagnosis and development of alcoholic liver disease (author's transl)]. | In a group of 205 patients with alcoholic diseases of liver the diagnostic relevance of biochemical tests (GOT, GPT, AP, GGTP, BSP) was reconsidered with discriminatory process (separation of diagnosis). The group contained 16 patients with nutritional-caused and 41 cases with alcoholic-caused fatty-infiltration of liv... | [Relevance of biochemistry in diagnosis and development of alcoholic liver disease (author's transl)]. In a group of 205 patients with alcoholic diseases of liver the diagnostic relevance of biochemical tests (GOT, GPT, AP, GGTP, BSP) was reconsidered with discriminatory process (separation of diagnosis). The group con... | [
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PMID:3727 | Proline endopeptidase and exopeptidase activity in polymorphonuclear granulocytes. | Peptidases capable of releasing proline residues from polypeptides are present in the cytoplasmic fraction of rabbit polymorphonuclear granulocytes. This was shown with peptide substrates where proline is present either at the carboxy-terminal or within the polypeptide chain. Lysosomal and plasma membrane enzymes were ... | Proline endopeptidase and exopeptidase activity in polymorphonuclear granulocytes. Peptidases capable of releasing proline residues from polypeptides are present in the cytoplasmic fraction of rabbit polymorphonuclear granulocytes. This was shown with peptide substrates where proline is present either at the carboxy-te... | [
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PMID:3728 | [A compact form of DNA in solution. 2. Peculiarities of acidic titration of double-stranded DNA in PEG-containing water-salt solutions]. | The formation of compact double-stranded DNA molecules in PEG-containing watersalt solutions (0.3 M NaCl) may be observed within the pH-range 3-10; i.e. under conditions at which parameters of double-stranded DNA helices are not strongly different from those of B-form. At pH less than 3, when regularity of double helic... | [A compact form of DNA in solution. 2. Peculiarities of acidic titration of double-stranded DNA in PEG-containing water-salt solutions]. The formation of compact double-stranded DNA molecules in PEG-containing watersalt solutions (0.3 M NaCl) may be observed within the pH-range 3-10; i.e. under conditions at which para... | [
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PMID:3729 | [Changes in the chemical composition and physico-chemical characteristics of chromatin from spleens of mice during immunogenesis]. | Comparative studies have been carried out for the chemical composition and physico-chemical characteristics of chromatin isolated from spleens of non-immunized and immunized mice. It is found that the chromatin from spleens of immunized mice contains significantly more non-histone proteins and RNA, while the quantity o... | [Changes in the chemical composition and physico-chemical characteristics of chromatin from spleens of mice during immunogenesis]. Comparative studies have been carried out for the chemical composition and physico-chemical characteristics of chromatin isolated from spleens of non-immunized and immunized mice. It is fou... | [
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PMID:3737 | Correction of severe combined immunodeficiency by fetal liver cells. | As an alternative to bone-marrow transplantation, two infants with severe combined immunodeficiency who had no histocompatible donors were given intraperitoneal infusions of fresh liver cells from fetuses of eight and nine to 10 weeks. Transient graft-versus-host disease began at 42 and 52 days, respectively. Both infa... | Correction of severe combined immunodeficiency by fetal liver cells. As an alternative to bone-marrow transplantation, two infants with severe combined immunodeficiency who had no histocompatible donors were given intraperitoneal infusions of fresh liver cells from fetuses of eight and nine to 10 weeks. Transient graft... | [
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PMID:3730 | [Kinetics and mechanism of the 3H to 1H in C(8)H groups of purine derivatives]. | The pH-dependence of the 3H to 1H exchange between water and C(8)H groups of purine, adenine, 9-methyladenine, 7-methyladenine, hypoxanthine, guanine, xanthine as well as C(2)H groups of imidazole and benzimidazole was studied. It was shown that within the pH-ranges, where the majority of molecules under study are non... | [Kinetics and mechanism of the 3H to 1H in C(8)H groups of purine derivatives]. The pH-dependence of the 3H to 1H exchange between water and C(8)H groups of purine, adenine, 9-methyladenine, 7-methyladenine, hypoxanthine, guanine, xanthine as well as C(2)H groups of imidazole and benzimidazole was studied. It was shown... | [
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PMID:3753 | Cyclic AMP and neuroendocrine influence upon forelimb regeneration in the adult newt, Notophthalmus viridescens. | The influence of the nervous and endocrine systems upon successive stages of limb regeneration suggest possible neuroendocrine interaction(s). Intraperitoneal injections of various agents had no effects upon blastema formation. Chlorpromazine, administered alone or with hormones, retarded morphogenesis. Prolactin, dibu... | Cyclic AMP and neuroendocrine influence upon forelimb regeneration in the adult newt, Notophthalmus viridescens. The influence of the nervous and endocrine systems upon successive stages of limb regeneration suggest possible neuroendocrine interaction(s). Intraperitoneal injections of various agents had no effects upon... | [
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PMID:3759 | Impaired urinary acidification in the hypothyroid rat. | Since abnormalities in the renal handling of sodium and water in both the proximal and distal tubule have been described in primary hypothyroidism, this study was undertaken to examine renal tubular hydrogen secretion in this disorder. Metabolic acidosis was induced in hypothyroid rats (H) and their age matched control... | Impaired urinary acidification in the hypothyroid rat. Since abnormalities in the renal handling of sodium and water in both the proximal and distal tubule have been described in primary hypothyroidism, this study was undertaken to examine renal tubular hydrogen secretion in this disorder. Metabolic acidosis was induce... | [
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PMID:3757 | [2 new species of microsporidians (Protozoa, Microsporidia) from mosquitoes of the family Chironomidae]. | Two new species of microsporidians are described from the mosquitoes of the genus Chironomus collected in water bodies of the north-eastern USSR. Bacillidium chironomi sp. n. injuring the adipose tissue of the fourth stage larvae of Chironomus dorsalis Mg. has rod-shaped spores 15 (11 to 19) x 0.7 (0.6 to 0.9) mu in si... | [2 new species of microsporidians (Protozoa, Microsporidia) from mosquitoes of the family Chironomidae]. Two new species of microsporidians are described from the mosquitoes of the genus Chironomus collected in water bodies of the north-eastern USSR. Bacillidium chironomi sp. n. injuring the adipose tissue of the fourt... | [
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PMID:3760 | Electrical responses of isolated Nitella protoplasm--excitations or artifacts? | Isolated protoplasmic droplets of the alga Nitella were investigated with microelectrodes under current clamp conditions. The following observations were made: 1. Long pulses of either polarity yielded almost symmetric current-voltage relations. Near the rather small resting potential (inside negative) the measuring po... | Electrical responses of isolated Nitella protoplasm--excitations or artifacts? Isolated protoplasmic droplets of the alga Nitella were investigated with microelectrodes under current clamp conditions. The following observations were made: 1. Long pulses of either polarity yielded almost symmetric current-voltage relati... | [
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PMID:3761 | The action of Ca2+ , Mg2+ and H+ on the contraction threshold of frog skeletal muscle: Evidence for surface charges controlling electro-mechanical coupling. | The dependence of the threshold potential for contraction of pH and the concentration of Ca2+ and Mg2+ in the bathing solution was measured in frog skeletal muscle. Decreasing the pH from 10.3 to 4.65 resulted in a threshold shift to more positive potentials. Between pH 6.5 and 8.5 the concentration threshold was almos... | The action of Ca2+ , Mg2+ and H+ on the contraction threshold of frog skeletal muscle: Evidence for surface charges controlling electro-mechanical coupling. The dependence of the threshold potential for contraction of pH and the concentration of Ca2+ and Mg2+ in the bathing solution was measured in frog skeletal muscle... | [
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PMID:3766 | [Comparison of the pA2 of various beta blocking agents]. | The drug industry is now putting out specific beta 1 or beta 2 beta-blocking agents. The pA2 of various beta-blocking agents were determined on isolated organs-guinea pig atrium and trachea: practolol and acebutolol were considered as specific beta-1 inhibitors; butoxamine was a specific beta-2 inhibitor, while pindolo... | [Comparison of the pA2 of various beta blocking agents]. The drug industry is now putting out specific beta 1 or beta 2 beta-blocking agents. The pA2 of various beta-blocking agents were determined on isolated organs-guinea pig atrium and trachea: practolol and acebutolol were considered as specific beta-1 inhibitors; ... | [
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PMID:3767 | [Effects of adrenergic blockade on adipose tissue lipolysis provoked in cats and humans by intravenous perfusion of isoprenaline]. | An intravenous infusion of isoprenaline (1 mug/kg/mn during 4 h) elicited a rise in serum free fatty acids (FFA) and glucose in anaesthetised cats. The effect reached a peak in 1 h and was then maintained at a plateau level for the remainder of the infusion. Acebutolol and practolol (0,1-10 mg/kg, p.o.) were more poten... | [Effects of adrenergic blockade on adipose tissue lipolysis provoked in cats and humans by intravenous perfusion of isoprenaline]. An intravenous infusion of isoprenaline (1 mug/kg/mn during 4 h) elicited a rise in serum free fatty acids (FFA) and glucose in anaesthetised cats. The effect reached a peak in 1 h and was ... | [
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PMID:3769 | Bone marrow transplantation in children. | Bone marrow transplantation is a new concept in the treatment of leukemia and aplastic anemia. The problems seen in the transplanted patient are abundant and often life-threatening. Caring for these patients offers one of the most exciting challenges of nursing. The nurse not only acquires skill in caring for a patient... | Bone marrow transplantation in children. Bone marrow transplantation is a new concept in the treatment of leukemia and aplastic anemia. The problems seen in the transplanted patient are abundant and often life-threatening. Caring for these patients offers one of the most exciting challenges of nursing. The nurse not on... | [
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PMID:3780 | Control of adenylate cyclase from secretory vesicle membranes by beta-adrenergic agents and nerve growth factor. | Adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity of purified secretory vesicle membranes from the adrenal medulla is inhibited by I-isoproterenol and I-epinephrine, as well as by nerve growth factor (NGF). The effect of these agents was found to be dose-dependent and, in the case of the cate... | Control of adenylate cyclase from secretory vesicle membranes by beta-adrenergic agents and nerve growth factor. Adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity of purified secretory vesicle membranes from the adrenal medulla is inhibited by I-isoproterenol and I-epinephrine, as well as by ... | [
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PMID:3781 | Preliminary characterization of the acrasin of the cellular slime mold Polysphondylium violaceum. | Some species of cellular slime mold do not respond to cyclic AMP as an acrasin, or chemoattractant. In one such species, Polysphondylium violaceum, we have isolated and purified its acrasin and determined some of its chemical properties, which lead us to believe it is a small molecule of less than 1500 daltons. One pos... | Preliminary characterization of the acrasin of the cellular slime mold Polysphondylium violaceum. Some species of cellular slime mold do not respond to cyclic AMP as an acrasin, or chemoattractant. In one such species, Polysphondylium violaceum, we have isolated and purified its acrasin and determined some of its chemi... | [
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PMID:3778 | [The effect of hydrocortisone and insulin on the activity and isoenzymes of typrosine-alpha-ketoglutarate transaminase in the ctyostructures of the livers of rats of different ages]. | Administration of hydrocortisone or insulin and also a simultaneous use of these hormones in a high dose caused a marked elevation of the total activity of tyrosine-alpha-ketoglutaric transaminase and its anode and cathode isoenzymes in the soluble fraction of the liver in the sexually immature (weighing 100-110 g) and... | [The effect of hydrocortisone and insulin on the activity and isoenzymes of typrosine-alpha-ketoglutarate transaminase in the ctyostructures of the livers of rats of different ages]. Administration of hydrocortisone or insulin and also a simultaneous use of these hormones in a high dose caused a marked elevation of the... | [
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PMID:3797 | Effects of dietary vitamin D and calcium on lysyl oxidase activity in chick bone metaphyses. | Activity of lysyl oxidase, an enzyme responsible for production of aldehydic precursors for lysine-derived collagen crosslinks, was measured in tibial metaphyses from chicks receiving different dietary levels of vitamin D and Ca for 2 weeks after hatching. Enzyme activities were increased twofold in D-deficient chicks ... | Effects of dietary vitamin D and calcium on lysyl oxidase activity in chick bone metaphyses. Activity of lysyl oxidase, an enzyme responsible for production of aldehydic precursors for lysine-derived collagen crosslinks, was measured in tibial metaphyses from chicks receiving different dietary levels of vitamin D and C... | [
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PMID:3798 | Factors influencing nonspecific binding of glucocorticoids in myocardial tissue. | Myocardial slices from the left ventricle of cat hearts were incubated in Krebs-Henseleit buffer containing 10 mM glucose which were gassed with 95% O2 and 5% CO2. Tritiated dexamethasone (DEXA 0.171 MM) or methylprednisolone (MP 0.805 mM) was added under varying conditions of temperature, pH, and in the presence of va... | Factors influencing nonspecific binding of glucocorticoids in myocardial tissue. Myocardial slices from the left ventricle of cat hearts were incubated in Krebs-Henseleit buffer containing 10 mM glucose which were gassed with 95% O2 and 5% CO2. Tritiated dexamethasone (DEXA 0.171 MM) or methylprednisolone (MP 0.805 mM)... | [
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PMID:3799 | Arylamidase and cathepsin-A activity of normal and dystrophic human muscle. | Human skeletal muscle homogenate has been shown to contain enzymes that catalyze the hydrolysis of L-leucyl p-nitroanilide and carbobenzoxyglutamyl-L-tyrosine, known substrates, respectively, for arylamidase and cathepsin A. The muscle arylamidase was found to be inhibited by p-chloromercuribenzoate. Addition of Co2+ r... | Arylamidase and cathepsin-A activity of normal and dystrophic human muscle. Human skeletal muscle homogenate has been shown to contain enzymes that catalyze the hydrolysis of L-leucyl p-nitroanilide and carbobenzoxyglutamyl-L-tyrosine, known substrates, respectively, for arylamidase and cathepsin A. The muscle arylamid... | [
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PMID:3808 | Synthesis of some new phenothiazine derivatives of expected medicinal value. | 2-Chloroacetyl phenothiazines were reacted with certain phenols and salts of some acids under different conditions to yield 2-substituted acetylphenothiazines. Another series of 10-substituted phenothiazines was synthesized by treatment of 10-chloroacetylphenothiazine with either the appropriate amines or salts of the ... | Synthesis of some new phenothiazine derivatives of expected medicinal value. 2-Chloroacetyl phenothiazines were reacted with certain phenols and salts of some acids under different conditions to yield 2-substituted acetylphenothiazines. Another series of 10-substituted phenothiazines was synthesized by treatment of 10-... | [
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PMID:3810 | Morphological changes in the thymus of young and adult red-billed queleas Quelea quelea (aves). | In a wild population of red-billed queleas Quelea quelea L. (Ploceidae: weaver-birds) sampled throughout the year in East Africa, the thymus was found to enlarge in young birds shortly after hatching, remain enlarged during the juvenile stage, and regress towards the end of the postjuvenile moult. In adults, recrudesce... | Morphological changes in the thymus of young and adult red-billed queleas Quelea quelea (aves). In a wild population of red-billed queleas Quelea quelea L. (Ploceidae: weaver-birds) sampled throughout the year in East Africa, the thymus was found to enlarge in young birds shortly after hatching, remain enlarged during ... | [
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PMID:3811 | Histological changes associated with enlargement and regression of the thymus glands of the red-billed quelea Quelea quelea L. (Ploceidae: weaver-birds). | Thymic lobes form over 200 red-billed queleas, Quelea quelea L., were examined histologically. Samples were taken from embryos about to hatch, juveniles and adults. The lobes varied in size from very small to very enlarged (1- greater than 5 mm long). The constituent cell types are described in detail and the occurrenc... | Histological changes associated with enlargement and regression of the thymus glands of the red-billed quelea Quelea quelea L. (Ploceidae: weaver-birds). Thymic lobes form over 200 red-billed queleas, Quelea quelea L., were examined histologically. Samples were taken from embryos about to hatch, juveniles and adults. T... | [
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PMID:3812 | EMMA-4 analysis of iron in cells of the thymic cortex of a weaver-bird (Quelea quelea). | Combined morphological and analytical studies with the EMMA-4 analytical electron microscope have enabled very early erythroid cells to be identified within the cortex of enlarging thymic lobes of Quelea quelea. These early erythroid cells have pale cytoplasm (sometimes with ferritin-like crystals present), slightly pa... | EMMA-4 analysis of iron in cells of the thymic cortex of a weaver-bird (Quelea quelea). Combined morphological and analytical studies with the EMMA-4 analytical electron microscope have enabled very early erythroid cells to be identified within the cortex of enlarging thymic lobes of Quelea quelea. These early erythroi... | [
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PMID:3813 | The postcranial skeletons of the Triassic mammals Eozostrodon, Megazostrodon and Erythrotherium. | The purposes of this monograph are to describe the postcranial skeletons of the earliest known mammals, and to probe, in so far as possible by osteological study, biological questions concerning the habits and adaptations of these late Triassic forms. In this context, information on the background of this investigation... | The postcranial skeletons of the Triassic mammals Eozostrodon, Megazostrodon and Erythrotherium. The purposes of this monograph are to describe the postcranial skeletons of the earliest known mammals, and to probe, in so far as possible by osteological study, biological questions concerning the habits and adaptations o... | [
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PMID:3815 | Classical conditioning in the sea anemone, Cribrina xanthogrammica. | Earlier attempts to classically condition sea anemones have yielded inconclusive results. Using light as CS and shock as US, conditioning as distinguished from sensitization and pseudoconditioning was demonstrated in anemones. Procedural controls included substitution of light alone, shock alone, and random light and s... | Classical conditioning in the sea anemone, Cribrina xanthogrammica. Earlier attempts to classically condition sea anemones have yielded inconclusive results. Using light as CS and shock as US, conditioning as distinguished from sensitization and pseudoconditioning was demonstrated in anemones. Procedural controls inclu... | [
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PMID:3816 | Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats. | A multiple behavioral schedule with food reinforcement was designed to measure the drug-induced performance enhancement and non-effective activity in rats. The schedule, 20 min in duration, had CRF components in the 33 trials and extinction components in the inter-trial periods. During each trial, food reinforcement wa... | Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats. A multiple behavioral schedule with food reinforcement was designed to measure the drug-induced performance enhancement and non-effective activity in rats. The schedule, 20 min in duration, had CRF components in the 3... | [
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PMID:3821 | [Automatic method for determination of serum antistreptolysin]. | The AA. describe a method of determination of serum antistreptolysin employing "Technicon" AutoAnalyzer, this method permitting the execution of 40 determinations in an hour, with a time of analysis of about 16 minutes. The procedure of analysis is very easy, with a very high selectivity of values; a variation coeffici... | [Automatic method for determination of serum antistreptolysin]. The AA. describe a method of determination of serum antistreptolysin employing "Technicon" AutoAnalyzer, this method permitting the execution of 40 determinations in an hour, with a time of analysis of about 16 minutes. The procedure of analysis is very ea... | [
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PMID:3823 | On the influence of prostaglandin F2alpha-induced labor at term on the metabolism and coagulation of mother and fetus. | 11 pregnancies at term were terminated by dilatation of the uterine cervix, low amniotomy, and by intravenous administration of PGF2alpha. The average infusion time was 3 hours 55 minutes, and the average total dose of PGF2alpha amounted to 2.0 mg. Parameters of acid-base changes, carbohydrate and energic state changes... | On the influence of prostaglandin F2alpha-induced labor at term on the metabolism and coagulation of mother and fetus. 11 pregnancies at term were terminated by dilatation of the uterine cervix, low amniotomy, and by intravenous administration of PGF2alpha. The average infusion time was 3 hours 55 minutes, and the aver... | [
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PMID:3824 | Pulmonary microembolism: attenuated pulmonary vasoconstriction with prostaglandin inhibitors and antihistamines. | The mechanism(s) involved in the pulmonary vascular and airway responses to pulmonary microembolism have not been clearly defined. Therefore, we determined the effects of specific prostaglandin and histamine blockade on the hemodynamic and arterial blood gas tension responses to particulate microembolism (200 mu glass ... | Pulmonary microembolism: attenuated pulmonary vasoconstriction with prostaglandin inhibitors and antihistamines. The mechanism(s) involved in the pulmonary vascular and airway responses to pulmonary microembolism have not been clearly defined. Therefore, we determined the effects of specific prostaglandin and histamine... | [
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PMID:3828 | Carotid body control of coronary flow, myocardial oxidative metabolism, and cardiac catecholamines in the dog. | In a series of 11 dogs, selective stimulation of the carotid body receptors by hypoxic, hypercapnic, acidotic blood produces bradycardia, an increase of coronary flow, and greater release of norepinephrine from the heart; the coronary resistances are decreased. The same stimulation after vagotomy is no longer accompani... | Carotid body control of coronary flow, myocardial oxidative metabolism, and cardiac catecholamines in the dog. In a series of 11 dogs, selective stimulation of the carotid body receptors by hypoxic, hypercapnic, acidotic blood produces bradycardia, an increase of coronary flow, and greater release of norepinephrine fro... | [
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PMID:3831 | Noradrenergic subsensitivity of rat liver homogenates during chronic ethanol ingestion. | Prior studies indicated that chronic ethanol feeding induced noradrenergic subsensitivity of the cerebral cortex. Sensitivity was measured using the cAMP response of brain slices to norepinephrine (NE). In the present report we investigated the possibility that noradrenergic receptors in a visceral organ might be simil... | Noradrenergic subsensitivity of rat liver homogenates during chronic ethanol ingestion. Prior studies indicated that chronic ethanol feeding induced noradrenergic subsensitivity of the cerebral cortex. Sensitivity was measured using the cAMP response of brain slices to norepinephrine (NE). In the present report we inve... | [
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PMID:3832 | Interactions between drugs and saliva-stimulating parafilm and their implications in measurements of saliva drug levels. | The interaction between Parafilm and four tranquilizers in their neutral phosphate buffer solutions resulted in various degrees of loss of the drugs from the solutions. The values of loss ranged from 15 to 34% for chlorpromazine and 8 to 42% for butaperazine at the initial concentration range of 2 to 20 mug/ml at room ... | Interactions between drugs and saliva-stimulating parafilm and their implications in measurements of saliva drug levels. The interaction between Parafilm and four tranquilizers in their neutral phosphate buffer solutions resulted in various degrees of loss of the drugs from the solutions. The values of loss ranged from... | [
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PMID:3847 | Acid hydrolases in the odontoblast-predentin region of dentinogenically active teeth. | The presence of hyaluronoglucosidase (EC 3.2.1.35; hyaluronidase), beta-N-acetylglucosaminidase (EC 3.2.1.30), exo-1,4-beta-xylosidase (EC 3.2.1.37), and arylsulfatase (EC 3.1.6.1) in dentinogenically active odontoblasts isolated from the rat incisor has been demonstrated by means of biochemical methods. The possible f... | Acid hydrolases in the odontoblast-predentin region of dentinogenically active teeth. The presence of hyaluronoglucosidase (EC 3.2.1.35; hyaluronidase), beta-N-acetylglucosaminidase (EC 3.2.1.30), exo-1,4-beta-xylosidase (EC 3.2.1.37), and arylsulfatase (EC 3.1.6.1) in dentinogenically active odontoblasts isolated from... | [
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0.010... |
PMID:3848 | N-acetyl-beta-D-hexosaminidase system in synovial fluid. | The present study was undertaken with the object of examining the N-Acetyl-beta-D-hexosaminidase activity in joint effusions from non-inflammatory (osteoarthrosis) and inflammatory (rheumatoid arthritis, gouty arthritis and chondrocalcinosis) joint diseases. The biochemical properties of four purified molecular forms w... | N-acetyl-beta-D-hexosaminidase system in synovial fluid. The present study was undertaken with the object of examining the N-Acetyl-beta-D-hexosaminidase activity in joint effusions from non-inflammatory (osteoarthrosis) and inflammatory (rheumatoid arthritis, gouty arthritis and chondrocalcinosis) joint diseases. The ... | [
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PMID:3849 | [Gastroenterology yesterday and today]. | In the 40 years since the foundation of the "Schweizerische Gesellschaft fur Gastroenterologie", medicine - and with it gastroenterology - have markedly changed. New diseases and syndromes have been discovered and others have disappeared. New knowledge in basic sciences influences progress in diagnosis and therapy. In ... | [Gastroenterology yesterday and today]. In the 40 years since the foundation of the "Schweizerische Gesellschaft fur Gastroenterologie", medicine - and with it gastroenterology - have markedly changed. New diseases and syndromes have been discovered and others have disappeared. New knowledge in basic sciences influence... | [
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PMID:3851 | Sperm diaphorase: genetic polymorphism of a sperm-specific enzyme in man. | Human sperm contains en enzyme with diaphorase activity that appears to be unique to sperm. Electrophoretic analysis of the diaphorase activity in sperm of different individuals reveals three phenotypic patterns. This polymorphism can be explained in terms of two alleles segregating at an autosomal locus; the allele fr... | Sperm diaphorase: genetic polymorphism of a sperm-specific enzyme in man. Human sperm contains en enzyme with diaphorase activity that appears to be unique to sperm. Electrophoretic analysis of the diaphorase activity in sperm of different individuals reveals three phenotypic patterns. This polymorphism can be explaine... | [
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PMID:3852 | Acid precipitation and embryonic mortality of spotted salamanders, Ambystoma maculatum. | Spotted salamanders breed in temporary pools formed in early spring by melted snow and rain. Many of these pools reflect the low pH of precipitation in the northeastern United States. Egg mortality is low (less than 1 percent) in pools near neutrality, but high (greater than 60 percent) in pools more acid than pH 6. De... | Acid precipitation and embryonic mortality of spotted salamanders, Ambystoma maculatum. Spotted salamanders breed in temporary pools formed in early spring by melted snow and rain. Many of these pools reflect the low pH of precipitation in the northeastern United States. Egg mortality is low (less than 1 percent) in po... | [
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PMID:3853 | Antibodies to histones and histone-histone complexes: immunochemical evidence for secondary structure in histone 1. | Highly specific antibodies were raised to histone 1 (H 1) and the histone complexes H32-H42 AND H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in acid- or urea-treated H1. The antibodies showed different reactivities with chromosomes as compared to antibodies in ac... | Antibodies to histones and histone-histone complexes: immunochemical evidence for secondary structure in histone 1. Highly specific antibodies were raised to histone 1 (H 1) and the histone complexes H32-H42 AND H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in aci... | [
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0.027087360620498657,
-0.0... |
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