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PMID:4577 | Kinetic and pharmacological properties of the sodium channel of frog skeletal muscle. | Na channels of frog skeletal muscle are studied under voltage clamp and their properties compared with those of frog myelinated nerve. A standard mathematical model is fitted to the sodium currents measured in nerve and in muscle to obtain a quantitative description of the gating kinetics. At 5 degrees C the kinetics i... | Kinetic and pharmacological properties of the sodium channel of frog skeletal muscle. Na channels of frog skeletal muscle are studied under voltage clamp and their properties compared with those of frog myelinated nerve. A standard mathematical model is fitted to the sodium currents measured in nerve and in muscle to o... | [
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PMID:4578 | Cation transport in Escherichia coli. VIII. Potassium transport mutants. | Analysis of K transport mutants indicates the existence of four separate K uptake systems in Escherichia coli K-12. A high affinity system called Kdp has a Km of 2 muM, and Vmax at 37 degrees C of 150 mumol/g min. This system is repressed by growth in high concentrations of K. Two constitutive systems, TrkA and TrkD, h... | Cation transport in Escherichia coli. VIII. Potassium transport mutants. Analysis of K transport mutants indicates the existence of four separate K uptake systems in Escherichia coli K-12. A high affinity system called Kdp has a Km of 2 muM, and Vmax at 37 degrees C of 150 mumol/g min. This system is repressed by growt... | [
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PMID:4579 | Some properties of the pyruvate carboxylase from Pseudomonas fluorescens. | The pyruvate carboxylase of Pseudonomas fluorescens was purified 160-fold from cells grown on glucose at 20 degrees C. The activity of this purified enzyme was not affected by acetyl-coenzyme A or L-aspartate, but was strongly inhibited by ADP, which was competitive towards ATP. Pyruvate gave a broken double reciproca... | Some properties of the pyruvate carboxylase from Pseudomonas fluorescens. The pyruvate carboxylase of Pseudonomas fluorescens was purified 160-fold from cells grown on glucose at 20 degrees C. The activity of this purified enzyme was not affected by acetyl-coenzyme A or L-aspartate, but was strongly inhibited by ADP, ... | [
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PMID:4588 | Cyanide intoxication in the rat: physiological and neuropathological aspects. | Sodium cyanide was given to rats by intravenous infusion at a rate that would avert apnoea (the first sign of overdosage) in the majority. There was full physiological monitoring in a group under anaesthesia and more limited monitoring in an unanaesthetized group. White matter was damaged in six animals and grey matter... | Cyanide intoxication in the rat: physiological and neuropathological aspects. Sodium cyanide was given to rats by intravenous infusion at a rate that would avert apnoea (the first sign of overdosage) in the majority. There was full physiological monitoring in a group under anaesthesia and more limited monitoring in an ... | [
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PMID:4595 | Summer sequential graduate programs in nursing. | In 1970 Texas Woman's University, College of Nursing instituted summer sequential programs in nursing whereby a student could study for a master's degree by attending the University for three summers. A different clinical focus was added each year from 1970 to 1973. Three sequences have been completed, i.e., clinical f... | Summer sequential graduate programs in nursing. In 1970 Texas Woman's University, College of Nursing instituted summer sequential programs in nursing whereby a student could study for a master's degree by attending the University for three summers. A different clinical focus was added each year from 1970 to 1973. Three... | [
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PMID:4598 | The multiple assignment: an effective alternative for laboratory experiences. | The purpose of the study was to test out the efficacy of both the Traditional and the Multiple Assignment approaches to the laboratory experiences of students of nursing. The subjects were 22 students enrolled in the first quarter of an Associate Degree Nursing Program and placed in either the multiple or the tradition... | The multiple assignment: an effective alternative for laboratory experiences. The purpose of the study was to test out the efficacy of both the Traditional and the Multiple Assignment approaches to the laboratory experiences of students of nursing. The subjects were 22 students enrolled in the first quarter of an Assoc... | [
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PMID:4599 | Stability of some pyridoxal phosphate-dependent enzymes in vitamin B-6 deficient rats. | The effects of lowering the liver pyridoxal phosphate (PLP) concentration by vitamin B-6 deficiency on the stability of several rat liver enzymes were examined. Three PLP-dependent enzymes (serine dehydratase, ornithine-delta-aminotransferase, and tyrosine aminotransferase) and two non-PLP-dependent enzymes (glucose-6-... | Stability of some pyridoxal phosphate-dependent enzymes in vitamin B-6 deficient rats. The effects of lowering the liver pyridoxal phosphate (PLP) concentration by vitamin B-6 deficiency on the stability of several rat liver enzymes were examined. Three PLP-dependent enzymes (serine dehydratase, ornithine-delta-aminotr... | [
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PMID:4601 | Adsorption sites of kaolin. | The electrophoretic mobility and adsorptive properties of kaolin and kaolin pretreated with anionic and cationic materials were examined over a range of pH values. Pretreatment with anionic compounds had little effect on mobility, while adsorption of cationic species markedly reduced mobility. These results are explain... | Adsorption sites of kaolin. The electrophoretic mobility and adsorptive properties of kaolin and kaolin pretreated with anionic and cationic materials were examined over a range of pH values. Pretreatment with anionic compounds had little effect on mobility, while adsorption of cationic species markedly reduced mobilit... | [
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PMID:4602 | Electrode sensitive to sulfa drugs. | An electrode sensitive to sulfa drugs was constructed by using the iron(II)-bathophenanthroline chelate embedded in a liquid membrane. Rapid and Nernstian responses were exhibited against solutions of sulfamerazine and sulfisomidine ranging between 10(-3) and 10(-1) M in concentration. High selectivity was observed in ... | Electrode sensitive to sulfa drugs. An electrode sensitive to sulfa drugs was constructed by using the iron(II)-bathophenanthroline chelate embedded in a liquid membrane. Rapid and Nernstian responses were exhibited against solutions of sulfamerazine and sulfisomidine ranging between 10(-3) and 10(-1) M in concentratio... | [
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PMID:4603 | Liquid-solid chromatographic determination of 6-demethylgriseofulvin in urine. | A specific and quantitative liquid-solid chromatographic method for the determination of 6-demethylgriseofulvin in human urine is reported. The method consists of extraction into an organic solvent, addition of internal standard, and analysis by liquid-solid chromatography using a UV detector. Griseofulvin, if present,... | Liquid-solid chromatographic determination of 6-demethylgriseofulvin in urine. A specific and quantitative liquid-solid chromatographic method for the determination of 6-demethylgriseofulvin in human urine is reported. The method consists of extraction into an organic solvent, addition of internal standard, and analysi... | [
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PMID:4605 | Mass fragmentography of morphine: relationship between brain levels and analgesic activity. | Morphine levels in rat brain were measured by the multiple ion detection method (mass fragmentography), using a computer-controlled gas chromatograph-mass spectrometer, and were correlated with the analgesic activity of the narcotic at intervals up to 6 hours after the injection. Morphine levels in brain reached a peak... | Mass fragmentography of morphine: relationship between brain levels and analgesic activity. Morphine levels in rat brain were measured by the multiple ion detection method (mass fragmentography), using a computer-controlled gas chromatograph-mass spectrometer, and were correlated with the analgesic activity of the narc... | [
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PMID:4606 | Vasoconstrictor actions of delta8- and delta9-tetrahydrocannabinol in the rat. | Cardiovascular effects of delta8- and delta9-tetrahydrocannabinol (THC) were studied after systemic intravenous administration and intra-arterial administration into a perfused vascular bed in the urethane-anesthetized rat. Intravenous administration of delta8- and delta9-THC produced dose-related transient increases i... | Vasoconstrictor actions of delta8- and delta9-tetrahydrocannabinol in the rat. Cardiovascular effects of delta8- and delta9-tetrahydrocannabinol (THC) were studied after systemic intravenous administration and intra-arterial administration into a perfused vascular bed in the urethane-anesthetized rat. Intravenous admin... | [
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PMID:4607 | Possible involvement of a transmitter different from norepinephrine in the residual responses to nerve stimulation of the cat nictitating membrane after pretreatment with reserpine. | Pretreatment with reserpine (0.3 or 3 mg/kg, 24 hours before the experiment) reduced the norepinephrine (NE) levels in the medial muscle of the cat nictitating membrane to approximately 2% of the control values. Under these experimental conditions, the responses to postganglionic nerve stimulation were not abolished, r... | Possible involvement of a transmitter different from norepinephrine in the residual responses to nerve stimulation of the cat nictitating membrane after pretreatment with reserpine. Pretreatment with reserpine (0.3 or 3 mg/kg, 24 hours before the experiment) reduced the norepinephrine (NE) levels in the medial muscle o... | [
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PMID:4608 | Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase. | 3H-l-Alprenolol, a potent competitive beta adrenergic antagonist, binds to sites in rat pineal gland membranes. The properties of these binding sites were compared to those of the receptors which mediate the beta adrenergic activation of pineal adenylate cyclase. Both sites are highly stereospecific. The l-stereoisomer... | Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase. 3H-l-Alprenolol, a potent competitive beta adrenergic antagonist, binds to sites in rat pineal gland membranes. The properties of these binding sites were compared to those of the receptors which mediate th... | [
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PMID:4609 | A pharmacological analysis of neurally induced inhibition of carotid body chemoreceptor activity in cats. | Experiments were performed to determine the mechanism by which centrifugal impulses in the carotid sinus nerve (CSN) reduce the frequency of impulse traffic in afferent chemoreceptor fibers from the carotid body in cats. Recordings of chemoreceptor activity were made from single- or few-fiber preparations dissected off... | A pharmacological analysis of neurally induced inhibition of carotid body chemoreceptor activity in cats. Experiments were performed to determine the mechanism by which centrifugal impulses in the carotid sinus nerve (CSN) reduce the frequency of impulse traffic in afferent chemoreceptor fibers from the carotid body in... | [
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PMID:4610 | On the ability of narcotic antagonists to produce the narcotic cue. | The ability of narcotic antagonists to produce the narcotic cue was investigated in rats trained to discriminate fentanyl (0.04 mg/kg) from solvent. The partial antagonists pentazocine, cyclazocine and nalorphine were found to possess narcotic cuing activity whereas naloxone lacked any such action at doses up to 160 mg... | On the ability of narcotic antagonists to produce the narcotic cue. The ability of narcotic antagonists to produce the narcotic cue was investigated in rats trained to discriminate fentanyl (0.04 mg/kg) from solvent. The partial antagonists pentazocine, cyclazocine and nalorphine were found to possess narcotic cuing ac... | [
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PMID:4611 | Effect of para-aminohippurate on renal glutamine metabolism in the rat. | After para-aminohippurate (PAH) infusion into rats, urine pH decreased and urine ammonium excretion increased. Because augmented urine flow and decreased urine pH could not explain entirely the enhanced ammonium excretion, an increased ammonia production was postulated as a contributing influence. This was supported by... | Effect of para-aminohippurate on renal glutamine metabolism in the rat. After para-aminohippurate (PAH) infusion into rats, urine pH decreased and urine ammonium excretion increased. Because augmented urine flow and decreased urine pH could not explain entirely the enhanced ammonium excretion, an increased ammonia prod... | [
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PMID:4612 | Inhibition by sulfobromophthalein of mitochondrial translocation of anions and adenine nucleotides: effects upon liver adenosine triphosphate and possible correlation with inhibition of bile flow in the rat. | Unconjugated sulfobromophthalein (BSP) inhibits state III respiration of rat liver mitochondria. It competitively inhibits the translocation into mitochondria of citrate, malate, phosphate and adenosine diphosphate, as studied by the inhibitor stop method. A double-beam spectrophotometric study strongly suggests that g... | Inhibition by sulfobromophthalein of mitochondrial translocation of anions and adenine nucleotides: effects upon liver adenosine triphosphate and possible correlation with inhibition of bile flow in the rat. Unconjugated sulfobromophthalein (BSP) inhibits state III respiration of rat liver mitochondria. It competitivel... | [
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PMID:4613 | Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta. | The dissociation constants (KA values) of l-norepinephrine (l-NE) and seven other agonists acting on alpha adrenergic receptors in rabbit aorta strips were determined by analysis of concentration-response data before and after fractional inactivation of receptors with Dibenamine. In experiments to determine KA values, ... | Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta. The dissociation constants (KA values) of l-norepinephrine (l-NE) and seven other agonists acting on alpha adrenergic receptors in rabbit aorta strips were determined by analysis of concentration-response da... | [
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PMID:4614 | The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones. | 1. Intracellular pH (pHi) was measured using pH-sensitive glass micro-electrodes. The effects on pHi of CO2 applied externally and HCO3-, H+ and NH4+ injected iontophoretically, were investigated. 2. The transport numbers for iontophoretic injection into aqueous micro-droples were found by potentiometric titration to b... | The effect of carbon dioxide on the intracellular pH and buffering power of snail neurones. 1. Intracellular pH (pHi) was measured using pH-sensitive glass micro-electrodes. The effects on pHi of CO2 applied externally and HCO3-, H+ and NH4+ injected iontophoretically, were investigated. 2. The transport numbers for io... | [
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PMID:4615 | [Blood acid-base changes produced by variations of water oxygenation in the crab Carcinus maenas (author's transl)]. | 10 Blood acid-base changes were studied at 17 degrees C in immersed crabs (Carcinus maenas) exposed to hypoxic and hyperoxic conditions, by measuring the pH and the CO2 partial pressure, PbCO2, and by calculating the bicarbonate concentration. 20 Hyperoxia first induces a marked respiratory acidosis with a rise of PbCO... | [Blood acid-base changes produced by variations of water oxygenation in the crab Carcinus maenas (author's transl)]. 10 Blood acid-base changes were studied at 17 degrees C in immersed crabs (Carcinus maenas) exposed to hypoxic and hyperoxic conditions, by measuring the pH and the CO2 partial pressure, PbCO2, and by ca... | [
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PMID:4617 | The diagnosis and treatment of acid-base deranged dogs infected with Babesia canis. | A study was made of the acid-base status of Babesia canis infected dogs judged unlikely to recover after specific babesicidal drug therapy despite the use of blood transfusion and other conventional supportive measures. Such cases were invariably acidotic and responded well and often dramatically to supportive intraven... | The diagnosis and treatment of acid-base deranged dogs infected with Babesia canis. A study was made of the acid-base status of Babesia canis infected dogs judged unlikely to recover after specific babesicidal drug therapy despite the use of blood transfusion and other conventional supportive measures. Such cases were ... | [
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PMID:4624 | Regulation of cell volume and ion concentrations in a Halobacterium. | Changes in cell volume and ion content of a Halobacterium species are described in terms of the NaCl concentration (0.5--3.5M) and pH(4-8) of the suspending medium. Cell volume, per unit content of protein of bacteria in stationary phase cultures, rose as the [NaCl] of the growth medium was increased. Logarithmic-phase... | Regulation of cell volume and ion concentrations in a Halobacterium. Changes in cell volume and ion content of a Halobacterium species are described in terms of the NaCl concentration (0.5--3.5M) and pH(4-8) of the suspending medium. Cell volume, per unit content of protein of bacteria in stationary phase cultures, ros... | [
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PMID:4627 | Behavioral and psychodynamic dimensions of the new sex therapy. | The new sexual therapy, a brief outpatient treatment of sexual dysfunction consisting of structured sexual exercises and conjoint therapeutic sessions, is a systematic intergration of behavioral and psychodynamic elements. Formally consisting of many defining characteristics of a behavior therapy including the direct t... | Behavioral and psychodynamic dimensions of the new sex therapy. The new sexual therapy, a brief outpatient treatment of sexual dysfunction consisting of structured sexual exercises and conjoint therapeutic sessions, is a systematic intergration of behavioral and psychodynamic elements. Formally consisting of many defin... | [
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PMID:4628 | The use of microchemical techniques for the identification of new transmitter molecules in neurons. | The author reviews available microtechniques and results on cellular analysis of single neurons emphasizing the identification of putative neurotransmitter molecules. Highly sensitive microquantitative methods for identification and assay of known and putative neurotransmitters have been developed within the last 15 ye... | The use of microchemical techniques for the identification of new transmitter molecules in neurons. The author reviews available microtechniques and results on cellular analysis of single neurons emphasizing the identification of putative neurotransmitter molecules. Highly sensitive microquantitative methods for identi... | [
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PMID:4631 | Studies of introital colonization in women with recurrent urinary infections. V. The inhibitory activity of normal vaginal fluid on Proteus mirabilis and Pseudomonas aeruginosa. | Normal vaginal fluid from premenopausal volunteers was inoculated with 10 strains of Proteus mirabilis and 14 strains of Pseudomonas aeruginosa at pH's of 4.3, 4.6 and 4.9. All bacteria were killed at pH 4.3. Nine of 10 strains of Proteus mirabilis and 12 of 14 Pseudomonas aeruginosa were killed at pH 4.6. Only 4 of 14... | Studies of introital colonization in women with recurrent urinary infections. V. The inhibitory activity of normal vaginal fluid on Proteus mirabilis and Pseudomonas aeruginosa. Normal vaginal fluid from premenopausal volunteers was inoculated with 10 strains of Proteus mirabilis and 14 strains of Pseudomonas aeruginos... | [
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PMID:4632 | Successful autotransplantation of an intra-abdominal testis to the scrotum by microvascular technique. | An intra-abdominal testis in a child with prune belly syndrome was successfully transplanted to the scrotum by a microvascular technique. Immediate results were good with no palpable atrophy of the testis. Long-term results (fertility) will not be known for many years. The technique of microvascular anastomosis and its... | Successful autotransplantation of an intra-abdominal testis to the scrotum by microvascular technique. An intra-abdominal testis in a child with prune belly syndrome was successfully transplanted to the scrotum by a microvascular technique. Immediate results were good with no palpable atrophy of the testis. Long-term r... | [
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PMID:4633 | Two rare cases of ectopic testis. | A case of pubopenile testis and a case of perineal ectopic testis are presented. The mechanism of descensus is largely positive, possibly facilitated by raised intra-abdominal pressure. The testis is usually guided by the gubernaculum and ectopia results from gubernacular failure. The ectopic testis is relatively rare ... | Two rare cases of ectopic testis. A case of pubopenile testis and a case of perineal ectopic testis are presented. The mechanism of descensus is largely positive, possibly facilitated by raised intra-abdominal pressure. The testis is usually guided by the gubernaculum and ectopia results from gubernacular failure. The ... | [
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PMID:4634 | Familial persistent Müllerian duct syndrome. | Two phenotypically normal pre-adolescent brothers with bilateral undescended testes were found to have bilateral fallopian tubes, a uterus and a vagina that drained into the prostatic utricle. We have documented this condition radiographically for the first time, gained some insight into the pattern of inheritance and ... | Familial persistent Müllerian duct syndrome. Two phenotypically normal pre-adolescent brothers with bilateral undescended testes were found to have bilateral fallopian tubes, a uterus and a vagina that drained into the prostatic utricle. We have documented this condition radiographically for the first time, gained some... | [
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PMID:4640 | Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (II). Analysis by the uptake saturation model. | Curves of experimentally plotted log (dose ratio-1) vs.-log [B] for the antagonism between adrenergic beta-mimetics, isoproterenol (ISO) and trimetoquinol (TMQ), and various beta-antagonists in relaxation of guinea-pig trachea could not be reasonably fitted to Schild's equation which has been commonly used in the analy... | Studies on the mode of antagonism between adrenergic beta-mimetics and beta-blocking agents (II). Analysis by the uptake saturation model. Curves of experimentally plotted log (dose ratio-1) vs.-log [B] for the antagonism between adrenergic beta-mimetics, isoproterenol (ISO) and trimetoquinol (TMQ), and various beta-an... | [
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PMID:4645 | pH of sweat of patients with cystic fibrosis. | pH of the sweat from patients with cystic fibrosis and in controls was measured as a function of the sweat-rate using a fluorescence-pH-indicator (umbelliferone). In both populations sweat is acid at low sweat-rates and alkaline at high ones. The results do not favour an abnormality of the ductal H+-secretion as the pa... | pH of sweat of patients with cystic fibrosis. pH of the sweat from patients with cystic fibrosis and in controls was measured as a function of the sweat-rate using a fluorescence-pH-indicator (umbelliferone). In both populations sweat is acid at low sweat-rates and alkaline at high ones. The results do not favour an ab... | [
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PMID:4649 | Morphologic and biochemical changes in autolysing dog heart muscle. | The progressive changes in pH, lactate content, and light and electron microscopic appearances were studied in dog myocardium undergoing a 6-hour period of autolysis in vitro at 37 degrees C. and at room temperature. At 37 degrees C. there was a rapid cumulative fall in pH during the 1st hour after excision of the hear... | Morphologic and biochemical changes in autolysing dog heart muscle. The progressive changes in pH, lactate content, and light and electron microscopic appearances were studied in dog myocardium undergoing a 6-hour period of autolysis in vitro at 37 degrees C. and at room temperature. At 37 degrees C. there was a rapid ... | [
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PMID:4648 | [Conditioning of water regenerated from moisture-containing wastes]. | Conditioning of reclaimed water with minerals and trace elements by means of filters made of silver-plated natural minerals containing calcium, magnesium, fluoride and iodine ions has been investigated. On the basis of the investigations a complex filter made of silver plated minerals--dolomite and fluorite--has been d... | [Conditioning of water regenerated from moisture-containing wastes]. Conditioning of reclaimed water with minerals and trace elements by means of filters made of silver-plated natural minerals containing calcium, magnesium, fluoride and iodine ions has been investigated. On the basis of the investigations a complex fil... | [
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PMID:4647 | [Problem of "biological compatibility" of crew members during prolonged space flight and possible directions for its solution]. | The concept of biological compatibility of men can be defined as a phenomenon which includes an effect (that might be favorable or unfavorable) of one individuum on the other via trace amounts of chemicals released into their environment and micro-organisms. The paper presents the main results of studies of biological ... | [Problem of "biological compatibility" of crew members during prolonged space flight and possible directions for its solution]. The concept of biological compatibility of men can be defined as a phenomenon which includes an effect (that might be favorable or unfavorable) of one individuum on the other via trace amounts... | [
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PMID:4657 | Proteins of the hepatoma tissue culture cell plasma membrane. | The specificity of lactoperoxidase-catalyzed iodination for the proteins of the hepatoma tissue culture cell plasma membrane was examined by histochemical, biochemical, and cell fractionation techniques. Light microscope autoradiography of sectioned cells shows the incorporated label to be localized primarily at the pe... | Proteins of the hepatoma tissue culture cell plasma membrane. The specificity of lactoperoxidase-catalyzed iodination for the proteins of the hepatoma tissue culture cell plasma membrane was examined by histochemical, biochemical, and cell fractionation techniques. Light microscope autoradiography of sectioned cells sh... | [
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PMID:4658 | Lesion-induced synaptogenesis in brain: a study of dynamic changes in neuronal membrane specializations. | When incoming fibers to a given brain region are damaged and degenerate, the remaining undamaged fibers can, in some cases, form new synapses, and restore physiologically functional circuitry. Synaptic membrane events underlie this reconstruction: the connection between membranes is broken and reformed. | Lesion-induced synaptogenesis in brain: a study of dynamic changes in neuronal membrane specializations. When incoming fibers to a given brain region are damaged and degenerate, the remaining undamaged fibers can, in some cases, form new synapses, and restore physiologically functional circuitry. Synaptic membrane even... | [
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PMID:4659 | Preliminary characterization of the acetylcholine receptor in human erythrocytes. | The response of human erythrocytes to cholinergic ligands was studied with an electron spin resonance assay. The membrane response to carbamyl choline was found to be antagonized by atropine and, in the absence of calcium, by tetrodotoxin. Experiments with resealed ghosts showed that the membrane response to carbamyl c... | Preliminary characterization of the acetylcholine receptor in human erythrocytes. The response of human erythrocytes to cholinergic ligands was studied with an electron spin resonance assay. The membrane response to carbamyl choline was found to be antagonized by atropine and, in the absence of calcium, by tetrodotoxin... | [
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PMID:4660 | Effect of alcohol on elicited male sexual response. | Sixteen young men drunk three doses of alcohol and their sexual arousal was measured by the changes in penile diameter. The lowest alcohol dose (BAC of 0.025%) was associated with maximum penile diameter increase; marked suppression of response was found at BACs of 0.05% and above. | Effect of alcohol on elicited male sexual response. Sixteen young men drunk three doses of alcohol and their sexual arousal was measured by the changes in penile diameter. The lowest alcohol dose (BAC of 0.025%) was associated with maximum penile diameter increase; marked suppression of response was found at BACs of 0.... | [
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PMID:4661 | "Feeling no pain" differential responses to pain by alcoholics and nonalcoholics before and after drinking. | Whisky reduced the level of pain reported by alcoholics but had no effect on that reported by nonalcoholics. The results appear to be based on the joint effects of the alcoholic's expectation that alcohol has an analgesic effect and the physiological cues accompanying alcohol consumption. | "Feeling no pain" differential responses to pain by alcoholics and nonalcoholics before and after drinking. Whisky reduced the level of pain reported by alcoholics but had no effect on that reported by nonalcoholics. The results appear to be based on the joint effects of the alcoholic's expectation that alcohol has an ... | [
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PMID:4662 | Decrease of iconic memory after alcohol. | Alcohol did not alter the rate of information loss from iconic memory. However, there was a dose-related decrease in the total amount of information reported which was independent of the rate of information loss. | Decrease of iconic memory after alcohol. Alcohol did not alter the rate of information loss from iconic memory. However, there was a dose-related decrease in the total amount of information reported which was independent of the rate of information loss. | [
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PMID:4663 | The relationship between alcohol dosage and performance decrement in humans. | The effects of alcohol on human perceptual, cognitive and motor performance was assessed in a battery of tests, and the dose-response relationships for alcohol, important for the study of drug-alcohol interactions, established. | The relationship between alcohol dosage and performance decrement in humans. The effects of alcohol on human perceptual, cognitive and motor performance was assessed in a battery of tests, and the dose-response relationships for alcohol, important for the study of drug-alcohol interactions, established. | [
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PMID:4664 | Personality impairment in alcoholism. Its relation to regional cerebral blood flow and psychometric performance. | The psychiatric symptoms constituting three main syndromes of personality impairment ("defense," "low vitality" and "emotional deficiency") were homogeneous in alcoholic patients. Only the "low vitality" syndrome was associated with impaired psychometric performance and reduced cerebral blood flow. | Personality impairment in alcoholism. Its relation to regional cerebral blood flow and psychometric performance. The psychiatric symptoms constituting three main syndromes of personality impairment ("defense," "low vitality" and "emotional deficiency") were homogeneous in alcoholic patients. Only the "low vitality" syn... | [
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PMID:4665 | Group assertiveness training for alcoholics. | Six men alcoholics showed increased assertiveness and improvement in social and occupational status after attending a group assertiveness training program. | Group assertiveness training for alcoholics. Six men alcoholics showed increased assertiveness and improvement in social and occupational status after attending a group assertiveness training program. | [
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PMID:4666 | Viability of cells in ethanol. Role of alcohol dehydrogenase. | Rodent cells were found to contain a high level of alcohol dehydrogenase activity which was not inducible. Other hepatoma and nonhepatoma cell lines were tested and found to contain lower but measurable levels of alcohol dehydrogenase. | Viability of cells in ethanol. Role of alcohol dehydrogenase. Rodent cells were found to contain a high level of alcohol dehydrogenase activity which was not inducible. Other hepatoma and nonhepatoma cell lines were tested and found to contain lower but measurable levels of alcohol dehydrogenase. | [
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PMID:4668 | Alcohol-induced conditioned taste aversion in rats. Effect of concentration and prior exposure to alcohol. | The effects of prior opportunities to drink alcohol solutions on the subsequent production of conditioned taste aversion by the oral ingestion of alcohol were evaluated. The consumption of 5 and 7% alcohol solutions produced conditioned aversion; the consumption of 3% alcohol solution did not result in aversion. Prior ... | Alcohol-induced conditioned taste aversion in rats. Effect of concentration and prior exposure to alcohol. The effects of prior opportunities to drink alcohol solutions on the subsequent production of conditioned taste aversion by the oral ingestion of alcohol were evaluated. The consumption of 5 and 7% alcohol solutio... | [
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PMID:4667 | Plasma immunoreactive insulin and somatotropin in delirium tremens and alcoholic hallucinosis. | The glucose tolerance curve in alcoholics in delirium tremens was similar to that seen in hepatogenic diabetes. The secretion of immunoreactive insulin and somatotropin after glucose was similar in patients with delirium tremens and alcoholic hallucinosis. | Plasma immunoreactive insulin and somatotropin in delirium tremens and alcoholic hallucinosis. The glucose tolerance curve in alcoholics in delirium tremens was similar to that seen in hepatogenic diabetes. The secretion of immunoreactive insulin and somatotropin after glucose was similar in patients with delirium trem... | [
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PMID:4669 | Alcohol toxicity, blood alcohol concentration and body water in young and adult rats. | Young rats, with more body water, had lower blood alcohol concentrations than did older ones at several times after various doses. The young also recovered sooner from intoxication. The age difference in recovery increased with increasing dose. | Alcohol toxicity, blood alcohol concentration and body water in young and adult rats. Young rats, with more body water, had lower blood alcohol concentrations than did older ones at several times after various doses. The young also recovered sooner from intoxication. The age difference in recovery increased with increa... | [
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PMID:4670 | Estimated U.S. alcoholic beverage consumption, 1790-1860. | From 1790 to 1830 American consumption of alcoholic beverages generally rose, with an increased use of spirits, a high but declining consumption of hard cider, and a negligible intake of wine and beer. Intake of absolute alcohol peaked in 1830, at a rate twice that estimated for 1970. From 1830 to 1860 consumption fell... | Estimated U.S. alcoholic beverage consumption, 1790-1860. From 1790 to 1830 American consumption of alcoholic beverages generally rose, with an increased use of spirits, a high but declining consumption of hard cider, and a negligible intake of wine and beer. Intake of absolute alcohol peaked in 1830, at a rate twice t... | [
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PMID:4671 | Philosophies for educating about alcohol and other mood-modifying substance. Personal or social controls. | Groups of students, teachers, adult advisers to youth, civil-service supervisors and occupational-program consultants were in basic agreement on philosophies for educating about alcohol, marihuana, lysergide (LSD) and heroin. | Philosophies for educating about alcohol and other mood-modifying substance. Personal or social controls. Groups of students, teachers, adult advisers to youth, civil-service supervisors and occupational-program consultants were in basic agreement on philosophies for educating about alcohol, marihuana, lysergide (LSD) ... | [
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PMID:4672 | Drinking during pregnancy. | Pregnant women reported a decrease in the use of alcoholic beverages during pregnancy, often citing adverse physiological effects as a reason for the decline. | Drinking during pregnancy. Pregnant women reported a decrease in the use of alcoholic beverages during pregnancy, often citing adverse physiological effects as a reason for the decline. | [
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PMID:4676 | The APUD cell concept. | Embryonic neural crest cells have been traced to the primitive entoderm where they differentiate into a family of hormone-producing cells, APUD cells. The APUD cell concept explains many otherwise seemingly dissociated clinical circumstances involving endocrine glands and hormone production by tumors. | The APUD cell concept. Embryonic neural crest cells have been traced to the primitive entoderm where they differentiate into a family of hormone-producing cells, APUD cells. The APUD cell concept explains many otherwise seemingly dissociated clinical circumstances involving endocrine glands and hormone production by tu... | [
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PMID:4679 | Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect. | The effects of various narcotic analgesics on striatal homovanillic acid (HVA) content, hot plate time and rectal temperature in mice were compared in relation to dose and time. The hypothermia induced by narcotic analgesics did not correlate with the striat"al HVA increase. Pentazocine, cyclazocine and thebaine had no... | Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect. The effects of various narcotic analgesics on striatal homovanillic acid (HVA) content, hot plate time and rectal temperature in mice were compared in relation to dose and time. The hypothermia induced b... | [
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PMID:4680 | The role of new health practitioners in a prepaid group practice: provider differences in process and outcomes of medical care. | Practice patterns and patient-reported outcomes of care are compared in detail for ten physicians and 12 new health practitioners delivering ambulatory care in two departments of a prepaid group practice, the Columbia Medical Plan (CMP). All providers completed questionnaires for a 50 per cent random sample of patients... | The role of new health practitioners in a prepaid group practice: provider differences in process and outcomes of medical care. Practice patterns and patient-reported outcomes of care are compared in detail for ten physicians and 12 new health practitioners delivering ambulatory care in two departments of a prepaid gro... | [
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PMID:4681 | Communication patterns of doctors and their assistants. | Communication patterns between physicians and their assistants (Medex) were observed in 19 practices to describe and evaluated the nature of their relationship. Observations demonstrated that interaction around patient problems was approximately 30 minures per day and informal, with the Medex more often initiating the ... | Communication patterns of doctors and their assistants. Communication patterns between physicians and their assistants (Medex) were observed in 19 practices to describe and evaluated the nature of their relationship. Observations demonstrated that interaction around patient problems was approximately 30 minures per day... | [
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PMID:4689 | Sterol synthesis in the liver, intestine, and lung of the guinea pig. | The relative rates of sterol synthesis in the liver, ileum, and lung of the guinea pig have been studied by measuring the incorporation by tissue slices of 14C-labeled acetate into digitonin-precipitable sterols. The liver showed maximum incorporation of acetate at pH 6.5, the ileum at pH 7.5, and the lung at pH 6.0. T... | Sterol synthesis in the liver, intestine, and lung of the guinea pig. The relative rates of sterol synthesis in the liver, ileum, and lung of the guinea pig have been studied by measuring the incorporation by tissue slices of 14C-labeled acetate into digitonin-precipitable sterols. The liver showed maximum incorporatio... | [
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PMID:4693 | Autoregulatory system of insulin degradation in liver. II. Relationship between blood insulin levels and GSH-dependent insulin degrading activity in liver and blood. | An autoregulatory system of insulin degradation in the liver in which the rate of insulin metabolism changes in response to fluctuation in its blood levels, was investigated. In the plasma of rats and man in the absence of reduced glutathione (GSH), insulin degradation was not observed, but when a sufficient amount of ... | Autoregulatory system of insulin degradation in liver. II. Relationship between blood insulin levels and GSH-dependent insulin degrading activity in liver and blood. An autoregulatory system of insulin degradation in the liver in which the rate of insulin metabolism changes in response to fluctuation in its blood level... | [
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PMID:4722 | Envelope mutation promoting autolysis in Salmonella typhimurium. | Two strains independently isolated in Salmonella typhimurium display abnormal autolytic activity when nutrient broth becomes alkaline. They also show increased sensitivity to deoxycholate, EDTA, and sodium dodecyl sulfate. Response to acridine orange remains normal. In both strains a single stable mutation is responsib... | Envelope mutation promoting autolysis in Salmonella typhimurium. Two strains independently isolated in Salmonella typhimurium display abnormal autolytic activity when nutrient broth becomes alkaline. They also show increased sensitivity to deoxycholate, EDTA, and sodium dodecyl sulfate. Response to acridine orange rema... | [
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PMID:4727 | Ferredoxin-dependent photosynthetic reduction of nitrate and nitrite by particles of Anacystis nidulans. | The dark and light reduction of nitrate and nitrite by cell-free preparations of the blue-green alga Anacystis nidulans has been investigated. The three following methods have been successfully applied to the preparation of active particulate fractions from the alga cells: (a) shaking with glass beads, (b) lysozyme tre... | Ferredoxin-dependent photosynthetic reduction of nitrate and nitrite by particles of Anacystis nidulans. The dark and light reduction of nitrate and nitrite by cell-free preparations of the blue-green alga Anacystis nidulans has been investigated. The three following methods have been successfully applied to the prepar... | [
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PMID:4728 | Appearance of a syndrome similar to graft versus host reaction in C57 B1/6 mice bearing skin allogenic graft. | A syndrome similar to GVHR is described in mice of C57B1/6 strain during the WHT/Ht skin allografts rejection period. In all the cases the described thymus involution was associated with the hypertrophy of lymph nodes. Their volume increase is due to the high number of blastic pyroninophilic and plasma cells concomitan... | Appearance of a syndrome similar to graft versus host reaction in C57 B1/6 mice bearing skin allogenic graft. A syndrome similar to GVHR is described in mice of C57B1/6 strain during the WHT/Ht skin allografts rejection period. In all the cases the described thymus involution was associated with the hypertrophy of lymp... | [
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PMID:4729 | [Mycoplasma-like micro-organisms in malignant tumors and non-tumours dermatovenerological diseases. Electron microscopic investigations (author's transl)]. | In examination of the ultrastructure of excised tissue and other material from patients with various diseases, principally dermatovenerological affections and with malignant tumors, and in healthy control subjects, patterns suggesting mycoplasma were repeatedly found in certain diseases only. Specific attempts to isola... | [Mycoplasma-like micro-organisms in malignant tumors and non-tumours dermatovenerological diseases. Electron microscopic investigations (author's transl)]. In examination of the ultrastructure of excised tissue and other material from patients with various diseases, principally dermatovenerological affections and with ... | [
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PMID:4730 | [Chemical Investigation of Chronic Pancreatitis]. | We differentiate indirect and direct methods. The indirect methods include the examination of the blood (ESR, blood picture, electrolytes, especially calcium, for the exclusion of hyperparathyroidism, status of fat and liver enzymes, activity of alpha-amylase and lipase. More informative than a serum determination is t... | [Chemical Investigation of Chronic Pancreatitis]. We differentiate indirect and direct methods. The indirect methods include the examination of the blood (ESR, blood picture, electrolytes, especially calcium, for the exclusion of hyperparathyroidism, status of fat and liver enzymes, activity of alpha-amylase and lipase... | [
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PMID:4733 | Huntington's chorea. Changes in neurotransmitter receptors in the brain. | Neurotransmitter-receptor binding sites for apparent muscarinic cholinergic, beta-adrenergic, gamma-aminobutyric acid and serotonin receptors were measured in the caudate nucleus and frontal cerebral cortex from post-mortem brains of 16 patients with Huntington's chorea and 16 controls. In addition, the samples were as... | Huntington's chorea. Changes in neurotransmitter receptors in the brain. Neurotransmitter-receptor binding sites for apparent muscarinic cholinergic, beta-adrenergic, gamma-aminobutyric acid and serotonin receptors were measured in the caudate nucleus and frontal cerebral cortex from post-mortem brains of 16 patients w... | [
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PMID:4739 | [The effect of changes in the pH of the external solution on the afterpotentials of individual frog nodes of Ranvier]. | A decrease in pH to 5 elicited a small increase in afterdepolarization of a single Ranvier node and an increase in pH to 9 had no effect. Post-tetanic hyperpolarization decreases at pH 5 and its duration somewhat increases. An increase in pH to 9 also had no effect. Similar changes in afterdepolarization and post-tetan... | [The effect of changes in the pH of the external solution on the afterpotentials of individual frog nodes of Ranvier]. A decrease in pH to 5 elicited a small increase in afterdepolarization of a single Ranvier node and an increase in pH to 9 had no effect. Post-tetanic hyperpolarization decreases at pH 5 and its durati... | [
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PMID:4744 | Prolonged clinical and experimental follow-up of hospitalized schizophrenics. | 148 chronic schizophrenics admitted between 1938 and 1961 had previously been followed up. In 1972, they were re-examined, on the average 10 years after the first follow-up. 44 belonged to a series of patients studied between 1955 and 1957 with a battery of conditional reflex tests. The patients belonging to the experi... | Prolonged clinical and experimental follow-up of hospitalized schizophrenics. 148 chronic schizophrenics admitted between 1938 and 1961 had previously been followed up. In 1972, they were re-examined, on the average 10 years after the first follow-up. 44 belonged to a series of patients studied between 1955 and 1957 wi... | [
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PMID:4759 | [The state of prothrombin, plasminogen and fibrinogen in the newborn infant]. | The esterase activity of thrombin and plasmin on artificial substrates was used to study the kinetics of these enzymes by Lineweaver and Burk's method. In the plasma of new-born infants, plasmin obtained from streptokinase has an avidity comparable with that in adults. Thrombin is obtained by the action of staphylocoag... | [The state of prothrombin, plasminogen and fibrinogen in the newborn infant]. The esterase activity of thrombin and plasmin on artificial substrates was used to study the kinetics of these enzymes by Lineweaver and Burk's method. In the plasma of new-born infants, plasmin obtained from streptokinase has an avidity comp... | [
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PMID:4760 | Local renal graft-versus-host reaction: sequential ultrastructural study. | A sequential study has been made of the ultrastructure of local renal graft-versus-host reactions produced in cyclophosphamide-pretreated rats by injection of either allogeneic or xenogeneic (mouse) spleen cells beneath the renal capsule. Early in the reaction, immunoblasts were seen between the outer cortical tubules,... | Local renal graft-versus-host reaction: sequential ultrastructural study. A sequential study has been made of the ultrastructure of local renal graft-versus-host reactions produced in cyclophosphamide-pretreated rats by injection of either allogeneic or xenogeneic (mouse) spleen cells beneath the renal capsule. Early i... | [
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PMID:4765 | Functional abnormalities in renal cystic diseases. | The functions of a kidney, whether normal or cystic, can be conceptualized in terms of anatomy (glomerulus, proximal tubule, loop of Henle, distal convolution, and collecting duct), activity (volume regulation, dilution and concentration, acid-base regulation, potassium excretion, transport of organic molecules, and ca... | Functional abnormalities in renal cystic diseases. The functions of a kidney, whether normal or cystic, can be conceptualized in terms of anatomy (glomerulus, proximal tubule, loop of Henle, distal convolution, and collecting duct), activity (volume regulation, dilution and concentration, acid-base regulation, potassiu... | [
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PMID:4766 | Phosphate transport by isolated renal brush border vesicles. | A sodium dependent specific transport system for phosphate is present in the brush border microvilli but absent from the basal-lateral plasma membranes. The apparent affinity of this transport system for phosphate is 0.08 mM at 100 mM sodium and pH 7.4. It is inhibited competitively by arsenate with an apparent inhibit... | Phosphate transport by isolated renal brush border vesicles. A sodium dependent specific transport system for phosphate is present in the brush border microvilli but absent from the basal-lateral plasma membranes. The apparent affinity of this transport system for phosphate is 0.08 mM at 100 mM sodium and pH 7.4. It is... | [
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PMID:4767 | The effect of carbonic anhydrase inhibition on bicarbonate reabsorption. | Renal reabsorption of bicarbonate was studied in Merino ewes during carbonic anhydrase inhibition. Bicarbonate reabsorption was directly proportional to plasma bicarbonate concentration. No tubular maximum for bicarbonate was demonstrated. Elevation of arterial PCO2 or depression of arterial pH caused slight increases ... | The effect of carbonic anhydrase inhibition on bicarbonate reabsorption. Renal reabsorption of bicarbonate was studied in Merino ewes during carbonic anhydrase inhibition. Bicarbonate reabsorption was directly proportional to plasma bicarbonate concentration. No tubular maximum for bicarbonate was demonstrated. Elevati... | [
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PMID:4779 | Atherosclerotic cerebral infarction: pathophysiologic aspects. | When the supply of substrate to the brain is threatened, homeostatic mechanisms induce cerebral vasodilatation to compensate for the insufficiency. When a region of the brain is rendered completely ischemic, local infarction occurs. The size of the infarct depends partly on the availability of collateral circulation an... | Atherosclerotic cerebral infarction: pathophysiologic aspects. When the supply of substrate to the brain is threatened, homeostatic mechanisms induce cerebral vasodilatation to compensate for the insufficiency. When a region of the brain is rendered completely ischemic, local infarction occurs. The size of the infarct ... | [
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PMID:4780 | Pharmacologic therapy of asthma. | Asthma is treated by avoiding the precipitants of symptoms, by a trial of hyposensitization (immunotherapy) if the precipitant cannot be avoided, and principally by pharmacologic therapy. Acute attacks have been most widely treated with epinephrine, but adrenergic aerosol bronchodilators and aminophylline are being use... | Pharmacologic therapy of asthma. Asthma is treated by avoiding the precipitants of symptoms, by a trial of hyposensitization (immunotherapy) if the precipitant cannot be avoided, and principally by pharmacologic therapy. Acute attacks have been most widely treated with epinephrine, but adrenergic aerosol bronchodilator... | [
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PMID:4781 | Managing acute urticaria. | The physician should be familiar with preventive measures for acute urticaria or its most severe form, anaphylaxis, and with the general principles of management. Treatment does not differ basically whether given in a nonmedical setting, the emergency room, or the office, except for the availability of special supplies... | Managing acute urticaria. The physician should be familiar with preventive measures for acute urticaria or its most severe form, anaphylaxis, and with the general principles of management. Treatment does not differ basically whether given in a nonmedical setting, the emergency room, or the office, except for the availa... | [
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PMID:4782 | Myocardial ischemia from coronary arterial spasm. | Spasm of coronary arteries can cause chest pain indistinguishable from classic angina pectoris in patients without atherosclerosis of these vessels or recognizable heart disease. Associated electrocardiographic changes usually correspond to the coronary artery affected and disappear when the attack of pain ends. Sublin... | Myocardial ischemia from coronary arterial spasm. Spasm of coronary arteries can cause chest pain indistinguishable from classic angina pectoris in patients without atherosclerosis of these vessels or recognizable heart disease. Associated electrocardiographic changes usually correspond to the coronary artery affected ... | [
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PMID:4777 | Preparation of drugs used in hyperacidity. Part I. Effects of pH of precipitation on the neutralizing properties of alumina gels. | Alumina gels were obtained from sodium aluminate by addition of 3 N HNO3, HCl or H2SO4 solutions or by saturation with gaseous CO2. The effect of several physicochemical factors (pH of precipitation, kind and concentration of precipitating agent, temperature) on the neutralizing properties of the obtained forms of Al(O... | Preparation of drugs used in hyperacidity. Part I. Effects of pH of precipitation on the neutralizing properties of alumina gels. Alumina gels were obtained from sodium aluminate by addition of 3 N HNO3, HCl or H2SO4 solutions or by saturation with gaseous CO2. The effect of several physicochemical factors (pH of preci... | [
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PMID:4778 | Nephron function in acute glycerol-induced renal insufficiency in rabbits. | The effect of acute experimentally induced renal failure after intramuscular injection of glycerol on serum and urine GGTP, LAP and AP activities was studied in 30 rabbits. High doses of glycerol caused shock, myolysis and hemolysis, leading to acute renal insufficiency. Serum urea and creatinine levels significantly i... | Nephron function in acute glycerol-induced renal insufficiency in rabbits. The effect of acute experimentally induced renal failure after intramuscular injection of glycerol on serum and urine GGTP, LAP and AP activities was studied in 30 rabbits. High doses of glycerol caused shock, myolysis and hemolysis, leading to ... | [
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PMID:4783 | Angina pectoris. Diagnosis and treatment. | The physician who understands the pathophysiology of angina pectoris can apply rational therapeutic measures based on an appreciation of the determinants of myocardial oxygen supply and demand. Most patients with angina secondary to coronary atherosclerosis can be treated conservatively using a systematic approach that... | Angina pectoris. Diagnosis and treatment. The physician who understands the pathophysiology of angina pectoris can apply rational therapeutic measures based on an appreciation of the determinants of myocardial oxygen supply and demand. Most patients with angina secondary to coronary atherosclerosis can be treated conse... | [
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PMID:4785 | Intranasal beclomethasone dipropionate in seasonal rhinitis in general practice. | Thirty-five patients with seasonal allergic rhinitis were treated in a double-blind comparative trial in and East London Group Practice with either beclomethasone dipropionate (50 micrograms in each nostril four times a day) or a placebo aerosol preparation identical in appearance. There was a statistically significant... | Intranasal beclomethasone dipropionate in seasonal rhinitis in general practice. Thirty-five patients with seasonal allergic rhinitis were treated in a double-blind comparative trial in and East London Group Practice with either beclomethasone dipropionate (50 micrograms in each nostril four times a day) or a placebo a... | [
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PMID:4786 | [Cerebral palsy--early diagnosis and treatment (author's transl)]. | The main aim of the present Conference has been to debate that early diagnosis and treatment of cerebral palsy. The Conference was attended by specialists taking care of the child with cerebral palsy (C.P.): child neurologists, surgeons--orthopedists, psychologists, rehabilitants, pediatricians. In connection with the ... | [Cerebral palsy--early diagnosis and treatment (author's transl)]. The main aim of the present Conference has been to debate that early diagnosis and treatment of cerebral palsy. The Conference was attended by specialists taking care of the child with cerebral palsy (C.P.): child neurologists, surgeons--orthopedists, p... | [
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PMID:4787 | [Congenital heart malformations in neonates, infants and young children (author's transl)]. | Congenital heart malformations in neonates, infants and young children represent the main problem of paediatric cardiology in Poland. Congenital cardiovascular diseases (incidence also approximately 8 per 1000 in liveborn infants) cause very high mortality, particularly in the neonatal and infantile period. Approximate... | [Congenital heart malformations in neonates, infants and young children (author's transl)]. Congenital heart malformations in neonates, infants and young children represent the main problem of paediatric cardiology in Poland. Congenital cardiovascular diseases (incidence also approximately 8 per 1000 in liveborn infant... | [
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PMID:4788 | [Ribonuclease activity in the serum of children of various ages (author's transl)]. | The normal levels of ribonuclease activity in the serum of children of both sexes of various ages. The children into four age groups: thee 1st grous--from 1 to 7 days of age, the 2nd--from 1 to 12 months, 3rd--from 1 to 3 years, 4th--from 7 to 14 years of age. The ribonuclease activity amounted, in the various age grou... | [Ribonuclease activity in the serum of children of various ages (author's transl)]. The normal levels of ribonuclease activity in the serum of children of both sexes of various ages. The children into four age groups: thee 1st grous--from 1 to 7 days of age, the 2nd--from 1 to 12 months, 3rd--from 1 to 3 years, 4th--fr... | [
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PMID:4793 | Activation and nuclear translocation of protein kinase during transsynaptic induction of tyrosine 3-monooxygenase. | The tyrosine-3-monooxygenase activity [L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] of rat adrenal medulla is induced 20-24 hr after the injection of reserpine (16 mumol/kg intraperitoneally). This and other inducing stimuli increase the 3': 5'-cyclic AMP (cAMP) content in the... | Activation and nuclear translocation of protein kinase during transsynaptic induction of tyrosine 3-monooxygenase. The tyrosine-3-monooxygenase activity [L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating); EC 1.14.16.2] of rat adrenal medulla is induced 20-24 hr after the injection of reserpine (1... | [
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PMID:4794 | A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney. | Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not substrates for this enzyme. In agreement with published data, the 15-hydroxyprostagland... | A 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin A in rabbit kidney. Examination of a soluble fraction derived from homogenates of rabbit kidney papilla revealed the existence of a 15-hydroxyprostaglandin dehydrogenase specific for A-type prostaglandins. Prostaglandins of the E- and F-series were not ... | [
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PMID:4795 | Specific positions involved in enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G). | Covalent binding of benzo[a]pyrene to poly(G) was studied with the use of a radioactive assay and specifically labeled substrates to define the role of the 1, 3- and 6-positions of the hydrocarbon during this process. Binding was shown to be dependent on microsomes, NADPH, O2 and poly(G). 7, 8-Benzoflavone and 2', 2'-d... | Specific positions involved in enzyme catalyzed covalent binding of benzo[a]pyrene to poly(G). Covalent binding of benzo[a]pyrene to poly(G) was studied with the use of a radioactive assay and specifically labeled substrates to define the role of the 1, 3- and 6-positions of the hydrocarbon during this process. Binding... | [
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PMID:4796 | Simple model for hormone-activated adenylate cyclase systems. | A simple model is developed to explain the activation of rat liver plasma membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] by guanosine nucleotides and glucagon and the dependence of the cATALYTIC RATE ON Mg2+, H+, and substrate concentrations. The basic model proposes that the adenylate cyc... | Simple model for hormone-activated adenylate cyclase systems. A simple model is developed to explain the activation of rat liver plasma membrane adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] by guanosine nucleotides and glucagon and the dependence of the cATALYTIC RATE ON Mg2+, H+, and substrate c... | [
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PMID:4797 | Heat mutagenesis in bacteriophage T4: the transition pathway. | G-C leads to A-T transitions are induced by heat, and arise from the deamination of cytosine (5-hydroxymethylcytosine in the case of bacteriophage T4) generating uracil. The reaction is proton-catalyzed, and is also characteristic of acid mutagenesis. Mutation rates and activation energies of mutation are site-specific... | Heat mutagenesis in bacteriophage T4: the transition pathway. G-C leads to A-T transitions are induced by heat, and arise from the deamination of cytosine (5-hydroxymethylcytosine in the case of bacteriophage T4) generating uracil. The reaction is proton-catalyzed, and is also characteristic of acid mutagenesis. Mutati... | [
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PMID:4798 | beta-adrenergic receptors in rat liver: effects of adrenalectomy. | The response of rat liver adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] to catecholamines is enhanced after adrenalectomy. To investigate this phenomenon, we developed an in vitro assay for beta-adrenergic receptors of plasma membranes derived from livers of control and adrenalectomized rats, usin... | beta-adrenergic receptors in rat liver: effects of adrenalectomy. The response of rat liver adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] to catecholamines is enhanced after adrenalectomy. To investigate this phenomenon, we developed an in vitro assay for beta-adrenergic receptors of plasma membra... | [
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PMID:4799 | Thermodynamic studies of polymerization of deoxygenated sickle cell hemoglobin. | Solubilities of deoxygenated sickle cell hemoglobin (deoxy-Hb S), at varying pH and temperature over a range of concentrations encompassing those found in erythrocytes, were measured. The technique involved ultracentrifugation, which gave values of the supernatant concentration and the mass of the sedimented material. ... | Thermodynamic studies of polymerization of deoxygenated sickle cell hemoglobin. Solubilities of deoxygenated sickle cell hemoglobin (deoxy-Hb S), at varying pH and temperature over a range of concentrations encompassing those found in erythrocytes, were measured. The technique involved ultracentrifugation, which gave v... | [
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PMID:4812 | Difference in the number of insulin binding sites between cortisol-sensitive and cortisol-resistant lymphoma P1798 cells. | Cortisol-sensitive and cortisol-resistant lymphoma P1798 cells specifically bind [25I]insulin. Resistant lymphocytes bind 40% less insulin than sensitive cells. These results suggest that insulin (or insulin-like substances) may play a role in growth regulation and/or response of this tumor to glucocorticoid therapy. | Difference in the number of insulin binding sites between cortisol-sensitive and cortisol-resistant lymphoma P1798 cells. Cortisol-sensitive and cortisol-resistant lymphoma P1798 cells specifically bind [25I]insulin. Resistant lymphocytes bind 40% less insulin than sensitive cells. These results suggest that insulin (o... | [
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PMID:4813 | Action of histamine and its receptor blockers on uterine circulation in sheep. | Effects of iv and ia administration of histamine and its H1 and H2 blockers (diphenhydramine and metiamide) on systemic arterial pressure, heart rate, and uterine and iliac blood flows were investigated in unanesthetized, chronically instrumented nonpregnant ewes. Intravenous histamine produced tachycardia, hypotension... | Action of histamine and its receptor blockers on uterine circulation in sheep. Effects of iv and ia administration of histamine and its H1 and H2 blockers (diphenhydramine and metiamide) on systemic arterial pressure, heart rate, and uterine and iliac blood flows were investigated in unanesthetized, chronically instrum... | [
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PMID:4814 | Alpha-MSH and MIF-2 effects on serotonin levels and accumulation in various rat brain areas. | Levels as well as accumulation of serotonin (5-HT) were measured in various brain regions of the rat after administration of alpha-melanocyte-stimulating hormone (MSH) and Pro-Leu-Gly-NH2 (MIF-I). The method used in determining the serotonin measured both 5-OH-tryptamine (5-HT) and 5-methoxytryptamine (5-MT). No statis... | Alpha-MSH and MIF-2 effects on serotonin levels and accumulation in various rat brain areas. Levels as well as accumulation of serotonin (5-HT) were measured in various brain regions of the rat after administration of alpha-melanocyte-stimulating hormone (MSH) and Pro-Leu-Gly-NH2 (MIF-I). The method used in determining... | [
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PMID:4815 | Alpha-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areas. | Attempts were made to find a biochemical correlate with previously observed behavioral alterations after administration of alpha-melanocyte-stimulating hormone (MSH) and MSH release-inhibiting factor (MIF-I). Brains of intact and hypophysectomized (hypox) rats were analyzed for endogenous catecholamine levels and the d... | Alpha-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areas. Attempts were made to find a biochemical correlate with previously observed behavioral alterations after administration of alpha-melanocyte-stimulating hormone (MSH) and MSH release-inhibiting factor (MIF-I). Brains of intact ... | [
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PMID:4818 | Self-administration of psychomotor stimulant drugs: the effects of unlimited access. | Rhesus monkeys surgically prepared with intravenous catheters were given 23 hr daily access to injection of either cocaine, d-amphetamine, 1-amphetamine, d-methamphetamine or diethylpropion on a fixed ratio 1 schedule of reinforcement for a maximum of 30 days. Responding was maintained by all these drugs but showed bot... | Self-administration of psychomotor stimulant drugs: the effects of unlimited access. Rhesus monkeys surgically prepared with intravenous catheters were given 23 hr daily access to injection of either cocaine, d-amphetamine, 1-amphetamine, d-methamphetamine or diethylpropion on a fixed ratio 1 schedule of reinforcement ... | [
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PMID:4819 | Rate-dependent effects of drugs: a review of the literature. | It has been claimed that the effects of amphetamines on schedule-controlled behavior depend to a large extent on the rate of responding in control conditions. A review of the literature shows that there is considerable support for this hypothesis if the behavior is not suppressed by aversive procedures, is not under th... | Rate-dependent effects of drugs: a review of the literature. It has been claimed that the effects of amphetamines on schedule-controlled behavior depend to a large extent on the rate of responding in control conditions. A review of the literature shows that there is considerable support for this hypothesis if the behav... | [
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PMID:4816 | Effect of various 6-hydroxydopamine treatments during development on growth and ingestive behavior. | Destruction of catecholamine-containing fibers in brain at 5 days of age with intracisternal injection of 6-hydroxydopamine reduced body growth, intake of a sucrose solution, and acquisition of an active avoidance response. Further characterization of behavioral deficits indicated that treated animals also showed reduc... | Effect of various 6-hydroxydopamine treatments during development on growth and ingestive behavior. Destruction of catecholamine-containing fibers in brain at 5 days of age with intracisternal injection of 6-hydroxydopamine reduced body growth, intake of a sucrose solution, and acquisition of an active avoidance respon... | [
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PMID:4820 | Schedule-induced oral self administration of etonitazene. | Rats were induced to drink either a saline-etonitazene solution or a saline solution with a schedule-induced polydipsia paradigm. When water was freely available, the rats continued to drink the saline solution or the saline-etonitazene solution, rather than the water. When the locations of the solutions were switched,... | Schedule-induced oral self administration of etonitazene. Rats were induced to drink either a saline-etonitazene solution or a saline solution with a schedule-induced polydipsia paradigm. When water was freely available, the rats continued to drink the saline solution or the saline-etonitazene solution, rather than the... | [
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PMID:4817 | Enzyme activity in sleep and sleep deprivation. | Liver tyrosine transaminase activity is low during the day when the rats are mostly asleep and high during the night when they are awake. When wakefulness was imposed for 8 hr during daylight on the day of the experiment and the rats were allowed to sleep for the following 3 hr during darkness, the tyrosine transaminas... | Enzyme activity in sleep and sleep deprivation. Liver tyrosine transaminase activity is low during the day when the rats are mostly asleep and high during the night when they are awake. When wakefulness was imposed for 8 hr during daylight on the day of the experiment and the rats were allowed to sleep for the followin... | [
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PMID:4830 | The genetics of the mimetic butterfly Hypolimnas bolina (L.). | Hypolimnas bolina is a Nymphalid butterfly having a west to east distribution from Madagascar to Easter Island, and a north to south one from Japan to Australasia. It is highly migratory in some areas. In much of the western part of its range the female is both monomorphic and a mimic of Euploea. Further east it is fre... | The genetics of the mimetic butterfly Hypolimnas bolina (L.). Hypolimnas bolina is a Nymphalid butterfly having a west to east distribution from Madagascar to Easter Island, and a north to south one from Japan to Australasia. It is highly migratory in some areas. In much of the western part of its range the female is b... | [
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PMID:4831 | Terrestrial vertebrates of the New Hebrides: origin and distribution. | The known terrestrial vertebrate fauna of the New Hebrides consists of 16 species of mammals (excluding feral domestic stock), 61 species of resident land- and freshwater birds, 20 species of reptiles and one amphibian. Of these, three, five, four and one species respectively have apparently been introduced by man. The... | Terrestrial vertebrates of the New Hebrides: origin and distribution. The known terrestrial vertebrate fauna of the New Hebrides consists of 16 species of mammals (excluding feral domestic stock), 61 species of resident land- and freshwater birds, 20 species of reptiles and one amphibian. Of these, three, five, four an... | [
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PMID:4832 | 5-Aminolaevulinic acid dehydratase: structure, function, and mechanism. | delta-Aminolaevulinic acid dehydratase catalyses the synthesis of porphobilinogen. The enzyme has a molecular mass of 285000 and is composed of eight similar subunits of molecular mass 35000. The N-terminal amino acid is acylated, and the number of peptides found on tryptic digestion equals the number of lysine and arg... | 5-Aminolaevulinic acid dehydratase: structure, function, and mechanism. delta-Aminolaevulinic acid dehydratase catalyses the synthesis of porphobilinogen. The enzyme has a molecular mass of 285000 and is composed of eight similar subunits of molecular mass 35000. The N-terminal amino acid is acylated, and the number of... | [
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PMID:4833 | Mechanism and stereochemistry of enzymic reactions involved in porphyrin biosynthesis. | 5-Aminolaevulinate synthetase cataylses the condensation of glycine and succinyl-CoA to give 5-aminolaevulinic acid. At least two broad pathways may be considered for the initial C--C bond forming step in the reaction. In pathway A the Schiff base of glycine and enzyme bound pyridoxal phosphate (a) undergoes decarboxyl... | Mechanism and stereochemistry of enzymic reactions involved in porphyrin biosynthesis. 5-Aminolaevulinate synthetase cataylses the condensation of glycine and succinyl-CoA to give 5-aminolaevulinic acid. At least two broad pathways may be considered for the initial C--C bond forming step in the reaction. In pathway A t... | [
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0.04986171796917915,
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0.02684740163385868,
-... |
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