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PMID:4834 | Biosynthesis of uroporphyrinogens from porphobilinogen: mechanism and the nature of the process. | The enzymic self-polymerization of prophobilinogen gives rise to the cyclic tetrapyrroles uroporphyrinogen III and uroporphyrinogen I. The former is the precursor of all the natural porphyrins and chlorins. The formation of uroporphyrinogen III is catalysed by a dual enzymic system, porphobilinogen deaminase and uropor... | Biosynthesis of uroporphyrinogens from porphobilinogen: mechanism and the nature of the process. The enzymic self-polymerization of prophobilinogen gives rise to the cyclic tetrapyrroles uroporphyrinogen III and uroporphyrinogen I. The former is the precursor of all the natural porphyrins and chlorins. The formation of... | [
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PMID:4835 | Biosynthesis of porphyrins and corrins. | Haem, chlorophyll and vitamin B12 are all derived ultimately from four molecules of the pyrrole porphobilinogen (PBG) and the initial enzyme catalysed condensation of PBG leads to the unsymmetrical type III isomer of uroporphyrinogen. On the basis of straightforward chemical considerations the type I isomer should be f... | Biosynthesis of porphyrins and corrins. Haem, chlorophyll and vitamin B12 are all derived ultimately from four molecules of the pyrrole porphobilinogen (PBG) and the initial enzyme catalysed condensation of PBG leads to the unsymmetrical type III isomer of uroporphyrinogen. On the basis of straightforward chemical cons... | [
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PMID:4836 | Synthesis of probable and improbable precursors for porphyrin biosynthesis. | Insights into details of the biomechanism by which porphobilinogen (1) cyclotetramerizes to uroporphyrinogen III (2) as well as promising synthetic applications are provided by investigation of this reaction in vitro. The cyclotetramerization of newly prepared norporphobilinogen (5) proved to be extemely specific due t... | Synthesis of probable and improbable precursors for porphyrin biosynthesis. Insights into details of the biomechanism by which porphobilinogen (1) cyclotetramerizes to uroporphyrinogen III (2) as well as promising synthetic applications are provided by investigation of this reaction in vitro. The cyclotetramerization o... | [
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PMID:4837 | Macrocyclic intermediates in the biosynthesis of porphyrins. | The hepta-, hexa- and penta-carboxylic porphyrins found in the faeces of rats poisoned with hexachlorobenzene have been separated by high-pressure liquid chromatography and characterized largely by spectroscopie methods. Their structures were confirmed by total synthesis, as part of a programme in which eleven of the f... | Macrocyclic intermediates in the biosynthesis of porphyrins. The hepta-, hexa- and penta-carboxylic porphyrins found in the faeces of rats poisoned with hexachlorobenzene have been separated by high-pressure liquid chromatography and characterized largely by spectroscopie methods. Their structures were confirmed by tot... | [
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PMID:4838 | Neovitamin B12 (cyano-13-epicobalamin). | Beta-Epimerization in the corrinoid system has recently emerged as a complicating factor in the latter stages of the total synthesis of vitamin B12 (Eschenmoser 1971; Woodward 1973). It has also found some application in biosynthetic studies on the origin of the methyl groups in ring C (Scott, Townsend & Cushley 19... | Neovitamin B12 (cyano-13-epicobalamin). Beta-Epimerization in the corrinoid system has recently emerged as a complicating factor in the latter stages of the total synthesis of vitamin B12 (Eschenmoser 1971; Woodward 1973). It has also found some application in biosynthetic studies on the origin of the methyl groups in ... | [
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PMID:4839 | The biosynthesis of vitamin B12. | The use of 13C-Fourier transform nuclear magnetic resonance (F.t.-n.m.r.) has led to the observation that while 8 molecules of [2-13C]ALA are incorporated into vitamin B12 in P. shermanii, [5-13C]ALA labels only seven of the carbon atoms of cyanocobalamin, i.e. one of the amino methyl groups of ALA is "lost" in the pro... | The biosynthesis of vitamin B12. The use of 13C-Fourier transform nuclear magnetic resonance (F.t.-n.m.r.) has led to the observation that while 8 molecules of [2-13C]ALA are incorporated into vitamin B12 in P. shermanii, [5-13C]ALA labels only seven of the carbon atoms of cyanocobalamin, i.e. one of the amino methyl g... | [
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PMID:4840 | Synthesis of corrins and related macrocycles based on pyrrolic intermediates. | Intermediate in structure between porphyrins and corrins are the corroles and 1-methyltetradehydrocorrins. These ring systems, like the porphyrins, can be obtained by cyclization of linear tetrapyrrolic compounds, reactions which have been shown to proceed by orbital symmetry-allowed electrocyclic processes, and exampl... | Synthesis of corrins and related macrocycles based on pyrrolic intermediates. Intermediate in structure between porphyrins and corrins are the corroles and 1-methyltetradehydrocorrins. These ring systems, like the porphyrins, can be obtained by cyclization of linear tetrapyrrolic compounds, reactions which have been sh... | [
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PMID:4841 | Chemical behavior of dicyanocob(III)yrinic acid heptamethyl ester and cob(I)yrinic acid heptamethyl ester in some preparative experiments. | Preparations of C10 acetate, trifluoroacetate, and chloro derivatives of dicyanocobyrinic acid heptamethyl ester ('cobester') are described. The nature and properties of intermediates in the synthesis of the 10-chloro derivative are discussed, and the electronic absorption spectra of the products are presented. | Chemical behavior of dicyanocob(III)yrinic acid heptamethyl ester and cob(I)yrinic acid heptamethyl ester in some preparative experiments. Preparations of C10 acetate, trifluoroacetate, and chloro derivatives of dicyanocobyrinic acid heptamethyl ester ('cobester') are described. The nature and properties of intermediat... | [
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PMID:4842 | Chemical reactivities of tetrapyrrole pigments: a comparison of experimentalbehaviour with the results of s.c.f.-pi-m.o. calculations. | Porphyrins are highly sigma-electron donating bases and very weak pi-acids. Hence they increase the electron density on central metal ions, e.g. iron, which leads to the specific reactivity of haem cytochromes, haemoglobin and oxidizing enzymes. The macrocyclic chlorin ligand behaves similarly but to a lesser degree w... | Chemical reactivities of tetrapyrrole pigments: a comparison of experimentalbehaviour with the results of s.c.f.-pi-m.o. calculations. Porphyrins are highly sigma-electron donating bases and very weak pi-acids. Hence they increase the electron density on central metal ions, e.g. iron, which leads to the specific react... | [
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PMID:4843 | The structures of some cobalamins in solution. | Nuclear magnetic resonance spectroscopy has been used to examine the conformations of cobalamins in solution. The perturbation of the resonances in the n.m.r. spectra by lanthanide probes provided particularly valuable information. Except for minor details the conformations are the same as those in the crystalline stat... | The structures of some cobalamins in solution. Nuclear magnetic resonance spectroscopy has been used to examine the conformations of cobalamins in solution. The perturbation of the resonances in the n.m.r. spectra by lanthanide probes provided particularly valuable information. Except for minor details the conformation... | [
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PMID:4844 | Control of 5-aminolaevulinate synthetase activity in Rhodopseudomonas spheroides. | Rhodopseudomonas spheroides can grow in a defined medium with either light or oxygen as an energy source. Cells grown anaerobically or at very low oxygen tensions are rich in the photosynthetic pigment bacteriochlorophyll, whereas this pigment is virtually absent in cells grown under high oxygen tensions. Aminolaevulin... | Control of 5-aminolaevulinate synthetase activity in Rhodopseudomonas spheroides. Rhodopseudomonas spheroides can grow in a defined medium with either light or oxygen as an energy source. Cells grown anaerobically or at very low oxygen tensions are rich in the photosynthetic pigment bacteriochlorophyll, whereas this pi... | [
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PMID:4847 | The structural subunit of glucose-6-phosphate dehydrogenase (baker's yeast). | The subunit molecular weight of glucose-6-phosphate dehydrogenase (G6PD) from baker's yeast has been evaluated. The subunit molecular weight value is shown to be 25,500 daltons by analytical ultracentrifugation, SDS-polyacrylamide gel electrophoresis, and the number of peptides produced by CNBr cleavage. The number of ... | The structural subunit of glucose-6-phosphate dehydrogenase (baker's yeast). The subunit molecular weight of glucose-6-phosphate dehydrogenase (G6PD) from baker's yeast has been evaluated. The subunit molecular weight value is shown to be 25,500 daltons by analytical ultracentrifugation, SDS-polyacrylamide gel electrop... | [
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PMID:4848 | Study of cystinaminopeptidase heterogeneity in animal sera by the isoelectric focusing method. | Study of the quantitative distribution of cystinaminopeptidase activity in the serum of pregnant and control animals (cow, sheep and rat) by the isoelectric focusing method showed heterogeneity of the cystinaminopeptidase activity of the animals' serum enzymatic system, which was well pronounced in the cow and rat and ... | Study of cystinaminopeptidase heterogeneity in animal sera by the isoelectric focusing method. Study of the quantitative distribution of cystinaminopeptidase activity in the serum of pregnant and control animals (cow, sheep and rat) by the isoelectric focusing method showed heterogeneity of the cystinaminopeptidase act... | [
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PMID:4849 | Thiopental anaesthesia and the acid-base balance in the blood of experimental dogs. | An analysis of basic parameters representative of the acid-base balance was made in arterial blood samples from 140 clinically healthy dogs, under a general intravenous Thiopental anaesthesia. The following mean values +/- S.E.M. were obtained: pH = 7.33 +/- 0.01; pCO2 = 47.16 +/- 0.95; base excess = -2.12 +/- 0.27; bu... | Thiopental anaesthesia and the acid-base balance in the blood of experimental dogs. An analysis of basic parameters representative of the acid-base balance was made in arterial blood samples from 140 clinically healthy dogs, under a general intravenous Thiopental anaesthesia. The following mean values +/- S.E.M. were o... | [
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PMID:4853 | Fast neutron and x-ray induced single strand DNA breaks in cultured mammalian cells. | The relative biologic effectiveness (RBE) of fast neutrons in the production of single strand DNA breaks is 1.6 as compared to that of 250 kVp x rays. Monolayers of L-929 cells were treated with dinitrophenol during irradiation to prevent the DNA strands from rejoining; the extent of DNA damage was measured by the alka... | Fast neutron and x-ray induced single strand DNA breaks in cultured mammalian cells. The relative biologic effectiveness (RBE) of fast neutrons in the production of single strand DNA breaks is 1.6 as compared to that of 250 kVp x rays. Monolayers of L-929 cells were treated with dinitrophenol during irradiation to prev... | [
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PMID:4854 | Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites. | Sulphasalazine (SZ) inhibits prostaglandin (PG) biosynthesis in vitro with a potency comparable to that of aceylsalicylate. The metabolites of SZ, sulphapyridine and 5-aminosalicylic acid, were of considerably lower potency as inhibitors of PG biosynthesis in the synthetase preparations used. Th inhibition of prostagla... | Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites. Sulphasalazine (SZ) inhibits prostaglandin (PG) biosynthesis in vitro with a potency comparable to that of aceylsalicylate. The metabolites of SZ, sulphapyridine and 5-aminosalicylic acid, were of considerably lower potency as inhibitors of... | [
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PMID:4855 | Partial characterization of prostaglandin synthetase in the reproductive tract of the male house cricket, Acheta domesticus. | An active prostaglandin (PG) synthetase was found in the 12100 g pellet of reproductive tract homogenates of the male house cricket, Acheta domesticus. Comparatively, the 12100 g supernatant and the microsomal fractions were inactive. The PG synthetase in the pellet fraction was characterized in terms of cofactor, temp... | Partial characterization of prostaglandin synthetase in the reproductive tract of the male house cricket, Acheta domesticus. An active prostaglandin (PG) synthetase was found in the 12100 g pellet of reproductive tract homogenates of the male house cricket, Acheta domesticus. Comparatively, the 12100 g supernatant and ... | [
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PMID:4857 | Hydroxyzine hydrochloride: possible adverse cardiac interactions. | Hydroxyzine hydrochloride may produce abnormal ventricular repolarization when given in substratial doses or to susceptible individuals. Phenothiazines, such as thioridazine, tricyclic antidepressants, or antiparkinson drugs, any of which may be given concurrently to psychiatric patients, may augment this effect as wel... | Hydroxyzine hydrochloride: possible adverse cardiac interactions. Hydroxyzine hydrochloride may produce abnormal ventricular repolarization when given in substratial doses or to susceptible individuals. Phenothiazines, such as thioridazine, tricyclic antidepressants, or antiparkinson drugs, any of which may be given co... | [
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PMID:4858 | Assessment of antipsychotic activity of an unique agent: SU-23397. | SU-23397 is a unique new hybrid molecule, the animal profile being characteristic of neuroleptic activity. Although the trial was uncontrolled, there appears to be no doubt that SU-23397 exerts antipsychotic activity between 20 mg and 250 mg daily in severely ill schizophrenic patients. Seven of the ten subjects requir... | Assessment of antipsychotic activity of an unique agent: SU-23397. SU-23397 is a unique new hybrid molecule, the animal profile being characteristic of neuroleptic activity. Although the trial was uncontrolled, there appears to be no doubt that SU-23397 exerts antipsychotic activity between 20 mg and 250 mg daily in se... | [
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PMID:4859 | The effect of various chlorpromazine derivatives on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. | The effects of chlorpromazine and of some metabolites of chlorpromazine on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity were investigated. Chlorpromazine, nor1-chlorpromazine and 7-hydroxychlorpromazine reverse the apomorphine-elicited inhibition of tyrosine hydroxylase activity whi... | The effect of various chlorpromazine derivatives on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. The effects of chlorpromazine and of some metabolites of chlorpromazine on the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity were investigated. Chlorprom... | [
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PMID:4860 | Effects of benzodiazepines on the binding of tryptophan in serum. Consequences on 5-hydroxyindoles concentrations in the rat brain. | Benzodiazepines (diazepam, oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin. As a result, in vivo treatment with one of these compounds (chlordiazepoxide for instance) induced a significant increase in the concentration of free tryptophan in serum. These observations ... | Effects of benzodiazepines on the binding of tryptophan in serum. Consequences on 5-hydroxyindoles concentrations in the rat brain. Benzodiazepines (diazepam, oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin. As a result, in vivo treatment with one of these compounds ... | [
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PMID:4861 | The search for the dopamine receptor: tribulations. | In an attempt to identify specific binding to dopamine receptors the binding of 3H-pimozide to preparations of brain and to an artificial cellulose membrane was examined. Binding occurred rapidly, was pH and temperature dependent, and was displaceable by other neuroleptics. Displaceable binding was saturable at 5 X 10(... | The search for the dopamine receptor: tribulations. In an attempt to identify specific binding to dopamine receptors the binding of 3H-pimozide to preparations of brain and to an artificial cellulose membrane was examined. Binding occurred rapidly, was pH and temperature dependent, and was displaceable by other neurole... | [
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PMID:4862 | Functional heterogeneity within neurotransmitter systems. | This paper reviews experiments that have revealed distinct differences between the dorsal and median raphe nuclei in the rat midbrain. The raphe nuclei appear to be hetrogeneous with respect to their anatomical projections to the forebrain, their relevance to specific behaviors, and their pharmacological responses. Sta... | Functional heterogeneity within neurotransmitter systems. This paper reviews experiments that have revealed distinct differences between the dorsal and median raphe nuclei in the rat midbrain. The raphe nuclei appear to be hetrogeneous with respect to their anatomical projections to the forebrain, their relevance to sp... | [
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PMID:4863 | Benzodiazepines and reproduction of swiss-webster mice. | Chronic dietary administration of 6 different benzodiazepine tranquilizers (chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, and nitrazepam) to breeding pairs of Swiss-Webster mice resulted in alterations of the normal patterns of reproductive behavior and fetal growth. Significant decreases in mating perfor... | Benzodiazepines and reproduction of swiss-webster mice. Chronic dietary administration of 6 different benzodiazepine tranquilizers (chlordiazepoxide, diazepam, oxazepam, prazepam, flurazepam, and nitrazepam) to breeding pairs of Swiss-Webster mice resulted in alterations of the normal patterns of reproductive behavior ... | [
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PMID:4864 | In vitro and in vivo studies of (1-sarcosine, 8-threonine) angiotensin II. | The capacity of (1-Sarcosine, 8-Threonine) angiotensin II to block the contractile and pressor effects of exogenous and endogenous angiotensin II was examined. In isolated rabbit aorta, the pA2 value (from pA2 plots) for the analog was 8.75 +/- 0.11. Both the maximum response and the slope of the dose-response curve to... | In vitro and in vivo studies of (1-sarcosine, 8-threonine) angiotensin II. The capacity of (1-Sarcosine, 8-Threonine) angiotensin II to block the contractile and pressor effects of exogenous and endogenous angiotensin II was examined. In isolated rabbit aorta, the pA2 value (from pA2 plots) for the analog was 8.75 +/- ... | [
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PMID:4865 | The effect of mercuric chloride intoxication on urinary psi-glutamyl transpeptidase excretion in the sheep. | The activity of the enzyme psi-glutamyl transpeptidase (psi-GT) was measured in the urine of sheep. In clinically normal animals the mean value was 6-3+/-0-6 mU/ml. In sheep with kidney damage induced by the administration of mercuric chloride there were marked increases in urinary concentrations of psi-GT, in some ca... | The effect of mercuric chloride intoxication on urinary psi-glutamyl transpeptidase excretion in the sheep. The activity of the enzyme psi-glutamyl transpeptidase (psi-GT) was measured in the urine of sheep. In clinically normal animals the mean value was 6-3+/-0-6 mU/ml. In sheep with kidney damage induced by the adm... | [
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PMID:4880 | Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease. | Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 and is inhibited by EDTA. Phosphodiesterase I (hydrolysis of thymidine-5'-monophospho-p-nitrophenylester) was also found in normal human seru... | Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease. Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 ... | [
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PMID:4881 | [The value of renin determination in the diagnosis of hypertension]. | Primary aldosteronism and renovascular hypertension are two different diseases in which renin determinations are necessary for establishment of diagnosis or therapeutic procedure. Low renin values which are not stimulated by acute stimuli combined with elevated plasma aldosterone concentrations confirm the diagnosis of... | [The value of renin determination in the diagnosis of hypertension]. Primary aldosteronism and renovascular hypertension are two different diseases in which renin determinations are necessary for establishment of diagnosis or therapeutic procedure. Low renin values which are not stimulated by acute stimuli combined wit... | [
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PMID:4894 | Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding. | A radioactively labeled alpha-adrenergic antagonist, [3H]dihydroergocryptine, binds specifically to a site on rabbit uterine membranes. Binding is rapid, reaching equilibrium in less than 17 minutes at 25 degrees C. Adrenergic agonists compete for this binding site with an order of affinities identical to the pharmacol... | Alpha-adrenergic receptor identification by (3H)dihydroergocryptine binding. A radioactively labeled alpha-adrenergic antagonist, [3H]dihydroergocryptine, binds specifically to a site on rabbit uterine membranes. Binding is rapid, reaching equilibrium in less than 17 minutes at 25 degrees C. Adrenergic agonists compete... | [
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PMID:4895 | Aspartate: distinct receptors on Aplysia neurons. | Aplysia neurons have specific aspartate receptors that are distinct from those to glutamate. In some cells, asparate selectively increases the membrane permeability to chloride, giving rise to a hyperpolarization, while on other cells it increases the permeability to sodium, causing a depolarization. There are also spe... | Aspartate: distinct receptors on Aplysia neurons. Aplysia neurons have specific aspartate receptors that are distinct from those to glutamate. In some cells, asparate selectively increases the membrane permeability to chloride, giving rise to a hyperpolarization, while on other cells it increases the permeability to so... | [
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PMID:4896 | Reduction in myocardial infarct size: prevention of heart cell death. | The course of myocardial necrosis, the clinical syndrome, and methods of treatment are presented. Heart cell death may be prevented by maintaining the balance between myocardial oxygen and energy supply and consumption. New technics of improving this balance by reducing myocardial energy demand, altering metabolism, in... | Reduction in myocardial infarct size: prevention of heart cell death. The course of myocardial necrosis, the clinical syndrome, and methods of treatment are presented. Heart cell death may be prevented by maintaining the balance between myocardial oxygen and energy supply and consumption. New technics of improving this... | [
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PMID:4897 | Hypo-acidity of gastric juice in chronic gastric ulceration caused by neutralisation. | Samples of gastric juice were aspirated every 15 minutes from 54 normal subjects and 31 patients with chronic gastric ulcers during a maximal histamine infusion test. The known tendency of patients with gastric ulcers to secrete a less acid gastric juice than that of normal subjects was confirmed. However, the hypo-aci... | Hypo-acidity of gastric juice in chronic gastric ulceration caused by neutralisation. Samples of gastric juice were aspirated every 15 minutes from 54 normal subjects and 31 patients with chronic gastric ulcers during a maximal histamine infusion test. The known tendency of patients with gastric ulcers to secrete a les... | [
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PMID:4898 | Antihypertensive therapy with timolol and alpha-methyldopa. A double-blind trial in patients with moderately severe hypertension. | After 24 moderately severe hypertensive patients had been treated for 4 weeks with a placebo for timolol, alpha-methyldopa was added and titrated until control of the blood pressure or a total daily dose of 2 500 mg was achieved. At the 9th week, the dose of alpha-methyldopa was halved and either timolol or its placebo... | Antihypertensive therapy with timolol and alpha-methyldopa. A double-blind trial in patients with moderately severe hypertension. After 24 moderately severe hypertensive patients had been treated for 4 weeks with a placebo for timolol, alpha-methyldopa was added and titrated until control of the blood pressure or a tot... | [
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PMID:4900 | Iatrogenic cryptorchidism resulting from hernia repair. | Nine children have been examined for iatrogenic cryptorchidism during a four year period. Wound infection and testicular retractility appear to be factors predisposing to this complication. Routine testicular palpation for position at the completion of hernia repair and the use of orchidopexy in selected patients shoul... | Iatrogenic cryptorchidism resulting from hernia repair. Nine children have been examined for iatrogenic cryptorchidism during a four year period. Wound infection and testicular retractility appear to be factors predisposing to this complication. Routine testicular palpation for position at the completion of hernia repa... | [
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PMID:4901 | The effect of antihistamines on experimental posttraumatic edema of the spinal cord. | The present experiments were designed to test the effect of antihistamines on the formation of post-traumatic edema of the spinal cord. Ten rhesus monkeys received 600 gm cm injuries to the T10 level of the spinal cord. Five animals received antihistamine treatment and five animals acted as untreated controls. Posttrau... | The effect of antihistamines on experimental posttraumatic edema of the spinal cord. The present experiments were designed to test the effect of antihistamines on the formation of post-traumatic edema of the spinal cord. Ten rhesus monkeys received 600 gm cm injuries to the T10 level of the spinal cord. Five animals re... | [
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PMID:4904 | Chemical studies of marine invertebrates. XVI. Structure and absolute configuration of lobosterol, a novel polyoxygenated sterol from the alcyonacean Lobophytum pauciflorum (clelenterata, octocorallia). | Lobosterol [(24S)-24-methylcholestane-3beta,4beta,5beta,25-tetrol-6-one 25 monoacetate] has been isolated from the Alcyonacean Lobophytum pauciflorum. The structural elucidation of this novel polyoxygenated sterol was achieved by chemical and spectroscopic evidence, and by X-ray diffraction analysis. | Chemical studies of marine invertebrates. XVI. Structure and absolute configuration of lobosterol, a novel polyoxygenated sterol from the alcyonacean Lobophytum pauciflorum (clelenterata, octocorallia). Lobosterol [(24S)-24-methylcholestane-3beta,4beta,5beta,25-tetrol-6-one 25 monoacetate] has been isolated from the Al... | [
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PMID:4905 | Irreversible protein binding of norethisterone (norethindrone) epoxide. | 14,15-3H-Norethisterone-4 beta, 5 beta-epoxide, a metabolite of norethisterone, was incubated with several proteins and nucleic acids. After 30 min incubation 0.19 nmol of the epoxide were irreversibly bound per mg albumin which contains free sulfhydryl groups; proteins without SH-groups, such as concanavalin A, gamma-... | Irreversible protein binding of norethisterone (norethindrone) epoxide. 14,15-3H-Norethisterone-4 beta, 5 beta-epoxide, a metabolite of norethisterone, was incubated with several proteins and nucleic acids. After 30 min incubation 0.19 nmol of the epoxide were irreversibly bound per mg albumin which contains free sulfh... | [
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PMID:4906 | Hydroxyapatite - a reagent for the separation of free and antibody-bound steroid during the radioimmunoassay. | The use of hydroxyapatite to absorb antibody-bound steroid and thus separate free and antibody-bound steroid during radioimmunoassay has been examined using three steroid antisera (to testosterone, to 17-hydroxyprogesterone and to estradiol-17beta). For all three antisera studied the separation was shown to be independ... | Hydroxyapatite - a reagent for the separation of free and antibody-bound steroid during the radioimmunoassay. The use of hydroxyapatite to absorb antibody-bound steroid and thus separate free and antibody-bound steroid during radioimmunoassay has been examined using three steroid antisera (to testosterone, to 17-hydrox... | [
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PMID:4907 | Influence of adrenergic receptor blockade on circulatory and metabolic effects of disordered neurotransmitter function in stroke patients. | Cerebral hemispheric blood flow and metabolism were measured before and after therapy with intracarotid infusion of combined PBZ and PPL in 15 patients with recent cerebral infarction. HBF was unaltered despite decrease in cerebral perfusion pressure. Cerebral hemispheric oxygen comsumption and carbon dioxide productio... | Influence of adrenergic receptor blockade on circulatory and metabolic effects of disordered neurotransmitter function in stroke patients. Cerebral hemispheric blood flow and metabolism were measured before and after therapy with intracarotid infusion of combined PBZ and PPL in 15 patients with recent cerebral infarcti... | [
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PMID:4913 | Action of beta-adrenergic blocking agents on the urethral pressure profile. | The action of beta-adrenergic blocking agents on the urethral pressure profile was studied. Sotalol, 20 mg, and inderal, 7 mg, were administered intravenously. Whereas the alpha-adrenergic blocking drug phentolamine, as already known, changed the maximum value of the pressure profile with an average decrease of 33%, th... | Action of beta-adrenergic blocking agents on the urethral pressure profile. The action of beta-adrenergic blocking agents on the urethral pressure profile was studied. Sotalol, 20 mg, and inderal, 7 mg, were administered intravenously. Whereas the alpha-adrenergic blocking drug phentolamine, as already known, changed t... | [
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PMID:4914 | [Urodynamic measurements in enuretics]. | Distal urethral stenosis in girls as well as meatal and bulbar narrowed urethral segments in boys are still subjects of discussion about their pathologic value in the literature. The urodynamic findings in enuretic children by urethral pressure profile and cystometry frequently point to a outflow resistance. Calibratio... | [Urodynamic measurements in enuretics]. Distal urethral stenosis in girls as well as meatal and bulbar narrowed urethral segments in boys are still subjects of discussion about their pathologic value in the literature. The urodynamic findings in enuretic children by urethral pressure profile and cystometry frequently p... | [
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PMID:4915 | Conservative bladder treatment in myelodysplasia. Differentiation of patients by cystomanometry. | Urodynamic evaluation was performed in 75 patients with congenital neuropathic bladder. Concerning treatment the most important parameters were detrusor tone, detrusor activity and bladder outlet resistance. Based on these findings individual conservative therapy was applied. Reflux or dilatation of the upper urinary t... | Conservative bladder treatment in myelodysplasia. Differentiation of patients by cystomanometry. Urodynamic evaluation was performed in 75 patients with congenital neuropathic bladder. Concerning treatment the most important parameters were detrusor tone, detrusor activity and bladder outlet resistance. Based on these ... | [
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PMID:4929 | [Treatment of hypertonus in diabetes mellitus]. | When pathophysiological and pathogenetic aspects of hypertension are taken into consideration with special regard to diabetes mellitus the exhaustion of the "insulin enhancement" within the cerebrovisceral functional systems (Baumann) are discussed and the authors enter possible connections of diabetes mellitus to the ... | [Treatment of hypertonus in diabetes mellitus]. When pathophysiological and pathogenetic aspects of hypertension are taken into consideration with special regard to diabetes mellitus the exhaustion of the "insulin enhancement" within the cerebrovisceral functional systems (Baumann) are discussed and the authors enter p... | [
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PMID:4930 | [The reaction of chorion epitheliums of human placentae to beta-sympathocomimetics (author's transl)]. | The enzyme histochemical response of chorionic epithelium after treatment with Dilatel has been examined on 50 placentae of classified eutrophic premature and full-term births. In relation to the degree of damage to trophoblasts at the start of treatment and to dosage the response is mobilisation and further differenti... | [The reaction of chorion epitheliums of human placentae to beta-sympathocomimetics (author's transl)]. The enzyme histochemical response of chorionic epithelium after treatment with Dilatel has been examined on 50 placentae of classified eutrophic premature and full-term births. In relation to the degree of damage to t... | [
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PMID:4932 | [PH-static pectin esterase analysis in sweet cherries (author's transl)]. | For the analysis of pectin esterase (PE) activities in sweet cherries some methods, as described in literature, were tested as to their usefulness in this specific range of application. The PE activities in dependence of the methods of extraction, the pH-value and the temperature were examined and a suitable procedure ... | [PH-static pectin esterase analysis in sweet cherries (author's transl)]. For the analysis of pectin esterase (PE) activities in sweet cherries some methods, as described in literature, were tested as to their usefulness in this specific range of application. The PE activities in dependence of the methods of extraction... | [
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PMID:4933 | [Phospholipase D - a review (author's transl)]. | Phospholipase D (phosphatidylcholine-phosphatidohydrolase, EC 3.1.4.4) hydrolyses lecithin into phosphatidic acid and choline. A review is given on the properties of phospholipase D described in the literature; it deals with the occurrence and distribution of phospholipase D in higher plants, with it's pH and temperatu... | [Phospholipase D - a review (author's transl)]. Phospholipase D (phosphatidylcholine-phosphatidohydrolase, EC 3.1.4.4) hydrolyses lecithin into phosphatidic acid and choline. A review is given on the properties of phospholipase D described in the literature; it deals with the occurrence and distribution of phospholipas... | [
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PMID:4938 | [Differential pharmacotherapy of neurotic conditions (comparative effectiveness of benzodiazepine derivatives)]. | The effectiveness in treating borderline states to a certain degree depends upon the pole (sthenic or asthenic) of the corresponding disturbance. Tranquilizers are the preparations of choice in the treatment of disorders of an asthenic pole (psychopathy of the asthenic range, neurotic states). In borderline conditions ... | [Differential pharmacotherapy of neurotic conditions (comparative effectiveness of benzodiazepine derivatives)]. The effectiveness in treating borderline states to a certain degree depends upon the pole (sthenic or asthenic) of the corresponding disturbance. Tranquilizers are the preparations of choice in the treatment... | [
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PMID:4939 | [The relationship between the state of the pulmonary circulation and indices of cerebral gas exchange in patients with acquired heart defects]. | The author studied the state of hemeostasis in normals and in patients with acquired heart insufficiency. By means of bloody methods of triple probe samples of the blood inflow and outflow from the brain, and by biochemical methods they also studied 22 normals and 100 patients with acquired heart insufficiency for inte... | [The relationship between the state of the pulmonary circulation and indices of cerebral gas exchange in patients with acquired heart defects]. The author studied the state of hemeostasis in normals and in patients with acquired heart insufficiency. By means of bloody methods of triple probe samples of the blood inflow... | [
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PMID:4941 | Effect of laser irradiation and immunosuppressive treatment on survival of mouse skin allotransplants. | The effect of laser beam on the survival of skin allotransplants has been studied. Irradiation of the donor skin and of the recipient graft bed improved the survival of the graft. The graft protecting effect of anti-thymocyte serum was considerably enhanced by laser irradiation. | Effect of laser irradiation and immunosuppressive treatment on survival of mouse skin allotransplants. The effect of laser beam on the survival of skin allotransplants has been studied. Irradiation of the donor skin and of the recipient graft bed improved the survival of the graft. The graft protecting effect of anti-t... | [
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PMID:4947 | Anesthesia for cesarean section III: effects of epidural analgesia on the respiratory adaptation of the newborn in elective cesarean section. | A rise in fetal Paco2 was observed after elective cesarean section in patients anesthetized both with a barbiturate and with nitrous oxide/oxygen. Epidural analgesia seemed to be a good alternative in order to attain better blood gas values in the newborn infant. Fourteen healthy mothers and their infants were studied ... | Anesthesia for cesarean section III: effects of epidural analgesia on the respiratory adaptation of the newborn in elective cesarean section. A rise in fetal Paco2 was observed after elective cesarean section in patients anesthetized both with a barbiturate and with nitrous oxide/oxygen. Epidural analgesia seemed to be... | [
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PMID:4948 | The effect of halothane anaesthesia upon cerebral oxygen consumption in the rat. | The influence of halothane (0.6 and 2%) upon cerebral (cortical) blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo2) was studied in artificially ventilated rats, using a modified technique of Kety & Schmidt (1948). The values obtained in halothane anaesthesia were compared to those recorded in nitrous o... | The effect of halothane anaesthesia upon cerebral oxygen consumption in the rat. The influence of halothane (0.6 and 2%) upon cerebral (cortical) blood flow (CBF) and cerebral metabolic rate for oxygen (CMRo2) was studied in artificially ventilated rats, using a modified technique of Kety & Schmidt (1948). The valu... | [
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PMID:4950 | Treatment of comatose patients by mechanical hyperventilation. | In case of cranial trauma, early respiratory troubles either of central or peripheral origin often accelerate the deterioration of the neurological situation. The different values of PCO2, PO2, pH and alcaline reserve measured on samples of CSF in comatose patients prove the central acidosis related to metabolic and va... | Treatment of comatose patients by mechanical hyperventilation. In case of cranial trauma, early respiratory troubles either of central or peripheral origin often accelerate the deterioration of the neurological situation. The different values of PCO2, PO2, pH and alcaline reserve measured on samples of CSF in comatose ... | [
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PMID:4952 | Resistant transitory epilepsy in children. | Three case histories are presented which are characterized by progressive, severe symptoms of mental and epileptic nature with EEG abnormalities of increasing severity culminating in "hypsarhythmia". The seizures were resistant to any treatment over a period of several months. Apparently spontaneous cures followed, and... | Resistant transitory epilepsy in children. Three case histories are presented which are characterized by progressive, severe symptoms of mental and epileptic nature with EEG abnormalities of increasing severity culminating in "hypsarhythmia". The seizures were resistant to any treatment over a period of several months.... | [
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PMID:4951 | A comparison of the cardiovascular effects of enflurane, halothane, methoxyflurane and fluroxene during open cardiac surgery. | During open heart surgery hemodynamic changes due to 1.5% enflurane, 0.75% halothane, 0.18% methoxyflurane and 3.4% fluroxene have been compared. The following parameters have been measured: arterial pressure, heart rate, cardiac output, right and left atrial pressure, left ventricular pressure and dp/dt. The strongest... | A comparison of the cardiovascular effects of enflurane, halothane, methoxyflurane and fluroxene during open cardiac surgery. During open heart surgery hemodynamic changes due to 1.5% enflurane, 0.75% halothane, 0.18% methoxyflurane and 3.4% fluroxene have been compared. The following parameters have been measured: art... | [
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PMID:4956 | Long-term hypotensive effect of atenolol (ICI 66.082), a new beta-adrenergic blocking agent. | A report is given from an on-going multicenter trial in Sweden, in which 117 hypertensive patients have been treated with a new cardioselective beta-adrenergic blocking agent, atenolol (ICI 66.082, Tenormin) for an average of six months (range 2-21). Statistically significant reductions of BP were observed, recumbent b... | Long-term hypotensive effect of atenolol (ICI 66.082), a new beta-adrenergic blocking agent. A report is given from an on-going multicenter trial in Sweden, in which 117 hypertensive patients have been treated with a new cardioselective beta-adrenergic blocking agent, atenolol (ICI 66.082, Tenormin) for an average of s... | [
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PMID:4953 | Bacteremia after tonsillectomy and adenectomy. | 40% of negative hemocultures become positive immediately after tonsillectomies and/or adenectomies. This bacteremia is asymptomatic and remains no longer than one hour. | Bacteremia after tonsillectomy and adenectomy. 40% of negative hemocultures become positive immediately after tonsillectomies and/or adenectomies. This bacteremia is asymptomatic and remains no longer than one hour. | [
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PMID:4957 | Hemodynamic long-term effects of timolol at rest and during exercise in essential hypertension. | Sixteen men with previously untreated essential hypertension in WHO stage I have been studied as out-patients. Oxygen consumption, heart rate (HR), cardiac output (Q) (Cardiogreen) and intraarterial brachial pressure were recorded at rest in supine and sitting position and during steady state work at 300, 600 and 900 k... | Hemodynamic long-term effects of timolol at rest and during exercise in essential hypertension. Sixteen men with previously untreated essential hypertension in WHO stage I have been studied as out-patients. Oxygen consumption, heart rate (HR), cardiac output (Q) (Cardiogreen) and intraarterial brachial pressure were re... | [
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PMID:4958 | [Energy state of the cerebral cortex of the cat during hyperventilation (author's transl)]. | Average Po2 and Pco2, local blood flow and pH values in the cerebral cortex of the cat were measured during passive hyperventilation (arterial Pco2 below 19 mm Hg). At defined intervals tissue samples were taken for metabolite analysis. The object of the study was to correlate the data obtained on the brain surface wit... | [Energy state of the cerebral cortex of the cat during hyperventilation (author's transl)]. Average Po2 and Pco2, local blood flow and pH values in the cerebral cortex of the cat were measured during passive hyperventilation (arterial Pco2 below 19 mm Hg). At defined intervals tissue samples were taken for metabolite a... | [
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PMID:4959 | [Postoperative mental blocking in a continuous reaction task. With supplementary results showing the influence of age (author's transl)]. | By means of a four colour device for measuring continuous reaction sequences the mental blockings of brain damaged patients in comparison with patients suffering from skin disease were determined. Differences due to age were also investigated. The analysis of frequency distribution of reaction times (dissection method ... | [Postoperative mental blocking in a continuous reaction task. With supplementary results showing the influence of age (author's transl)]. By means of a four colour device for measuring continuous reaction sequences the mental blockings of brain damaged patients in comparison with patients suffering from skin disease we... | [
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PMID:4963 | Immunosuppression by fetal liver as a model for tolerance to self. | The embryonic liver chimera system was used as a model to study the development of tolerance to self antigens. It was found that the permanent tolerant state which was induced in (C3H/eb x C57BL/6)F1 irradiated hosts following reconstitution with parental C57BL liver cells could be due to the development of suppressor ... | Immunosuppression by fetal liver as a model for tolerance to self. The embryonic liver chimera system was used as a model to study the development of tolerance to self antigens. It was found that the permanent tolerant state which was induced in (C3H/eb x C57BL/6)F1 irradiated hosts following reconstitution with parent... | [
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PMID:4964 | Suppressor cells in the embryonic thymus mediate allograft tolerance. | Thymus cells from non-immunized young chickens suppress the allograft rejection in lightly irradiated syngeneic or allogeneic recipients and mediate longlasting skingraft survival in a significant proportion of recipients across a strong histocompatibility difference. Suppressive activity of this kind is already found ... | Suppressor cells in the embryonic thymus mediate allograft tolerance. Thymus cells from non-immunized young chickens suppress the allograft rejection in lightly irradiated syngeneic or allogeneic recipients and mediate longlasting skingraft survival in a significant proportion of recipients across a strong histocompati... | [
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PMID:4970 | Internal mammary artery bypass graft in reoperative myocardioal revascularization. | Thirty-two consecutive patients who earlier received indirect or direct myocardial revascularization underwent reoperation with one or more internal mammary artery grafts either alone or in combination with saphenous vein grafts. The main indication for reoperation was graft closure or progression of coronary atheroscl... | Internal mammary artery bypass graft in reoperative myocardioal revascularization. Thirty-two consecutive patients who earlier received indirect or direct myocardial revascularization underwent reoperation with one or more internal mammary artery grafts either alone or in combination with saphenous vein grafts. The mai... | [
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PMID:4972 | Evaluation of a 5-mum stainless steel filter as an intravenous inline filter or prefilter. | The suitability of a 5-mum stainless steel filter as an inline filter or a protective prefilter during simulated i.v. therapy was evaluated using flow rate measurements of two routinely used i.v. fluids and parenteral nutrition fluid. As an inline i.v. filter, the 5-mum stainless steel filter was capable of maintaining... | Evaluation of a 5-mum stainless steel filter as an intravenous inline filter or prefilter. The suitability of a 5-mum stainless steel filter as an inline filter or a protective prefilter during simulated i.v. therapy was evaluated using flow rate measurements of two routinely used i.v. fluids and parenteral nutrition f... | [
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PMID:4973 | Hyperactive children and the efficacy of psychoactive drugs as a treatment intervention. | Characteristics of hyperactive children, including speculation in regard to etiology, are reviewed. Drug effects studies and drug treatment of hyperactive behavior are examined, and unresolved issues are discussed. Conclusions indicate that individual differences in hyperative children should form the basis for treatme... | Hyperactive children and the efficacy of psychoactive drugs as a treatment intervention. Characteristics of hyperactive children, including speculation in regard to etiology, are reviewed. Drug effects studies and drug treatment of hyperactive behavior are examined, and unresolved issues are discussed. Conclusions indi... | [
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PMID:4969 | Experiments on the role of virus infections in the pathogenesis of bronchial asthma. The role of innate or acquired insufficiency or ergotropic adaptation in the mechanism of genesis of bronchial asthma. | The wide mosaic of congruent clinical and experimental observations led to the postulation that the cause of the pharmacological abnormality of the asthmatic patient, i.e. the immensely increased reactivity of the bronchial smooth muscles, is to be sought in an insufficiency of the beta-adrenergic receptor system. It i... | Experiments on the role of virus infections in the pathogenesis of bronchial asthma. The role of innate or acquired insufficiency or ergotropic adaptation in the mechanism of genesis of bronchial asthma. The wide mosaic of congruent clinical and experimental observations led to the postulation that the cause of the pha... | [
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PMID:4974 | Ventilatory response to hypercapnia in the larger spotted dogfish Scyliorhinus stellaris. | Dogfish were exposed to sudden changes of Pco2 in inspired seawater. During hypercapnia breathing frequency remained constant, but gill ventilation was transiently increased to about 140% of control levels in the 1st h. O2 uptake was significantly increased also, but returned to the initial level before nomalization of... | Ventilatory response to hypercapnia in the larger spotted dogfish Scyliorhinus stellaris. Dogfish were exposed to sudden changes of Pco2 in inspired seawater. During hypercapnia breathing frequency remained constant, but gill ventilation was transiently increased to about 140% of control levels in the 1st h. O2 uptake ... | [
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PMID:4975 | Does hyperinsulinemia in ob/ob mice cause an insulin-stimulated adipose tissue? | After a 1-h preincubation to remove endogenous insulin, adipose tissue of obese mice (C57BL/L4 ob/ob) had a lower rate of glucose metabolism than tissue which was not preincubated. In contrast, preincubation did not change the metabolism of adipose tissue from lean mice (C57B1/6J +/+). The preincubation effect was abol... | Does hyperinsulinemia in ob/ob mice cause an insulin-stimulated adipose tissue? After a 1-h preincubation to remove endogenous insulin, adipose tissue of obese mice (C57BL/L4 ob/ob) had a lower rate of glucose metabolism than tissue which was not preincubated. In contrast, preincubation did not change the metabolism of... | [
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PMID:4976 | Importance of pulmonary ventilation in respiratory control in the bullfrog. | Pulmonary and cutaneous O2 consumption (Vo2) and CO2 production (Vco2) were measured simultaneously in bullfrogs Rana catesbeiana at 20 degrees C. The lungs were responsible for 77.3-91.0% of the total Vo2 and 28.5-74.9% of the total VCO2. The distribution of the total exchange between the lungs and skin depended on me... | Importance of pulmonary ventilation in respiratory control in the bullfrog. Pulmonary and cutaneous O2 consumption (Vo2) and CO2 production (Vco2) were measured simultaneously in bullfrogs Rana catesbeiana at 20 degrees C. The lungs were responsible for 77.3-91.0% of the total Vo2 and 28.5-74.9% of the total VCO2. The ... | [
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PMID:4977 | Electromyographic response of respiratory muscles during elastic loading. | The response of respiratory motor neurons to graded elastic loading was assessed in anesthetized dogs by recording the electromyogram (EMG) from the diaphragm (ED) and the intercostal muscle (EIC). Elastic loads were applied for 1-20 breaths. The effects of changes in PCO2 on respiratory motor neuron output was assesse... | Electromyographic response of respiratory muscles during elastic loading. The response of respiratory motor neurons to graded elastic loading was assessed in anesthetized dogs by recording the electromyogram (EMG) from the diaphragm (ED) and the intercostal muscle (EIC). Elastic loads were applied for 1-20 breaths. The... | [
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PMID:4978 | Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. | In five conscious dogs with gastric fistula and two duodenal cannulas, plasma RIA secretin and gastrin levels were determined in response to 1) infusion of 0.1 N HCl in the proximal duodenal cannula, 2) ingestion of a meal, and 3) intraduodenal infusion of 0.1 N HCl following ingestion of a meal. Significant increases ... | Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. In five conscious dogs with gastric fistula and two duodenal cannulas, plasma RIA secretin and gastrin levels were determined in response to 1) infusion of 0.1 N HCl in the proximal duodenal cannula, 2) ingestion of a meal, and 3) ... | [
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PMID:4979 | Intracellular pH of brain: alterations in acute respiratory acidosis and alkalosis. | To evaluate the metabolic adaptations of the brain to acute respiratory acid-base disturbances, a method was developed to measure intracellular pH (pHi) in the brain of dogs under conditions in which arterial pH is rapidly altered. Brain pHi was determined by measuring the distribution of 14C-labeled dimethadione (DMO)... | Intracellular pH of brain: alterations in acute respiratory acidosis and alkalosis. To evaluate the metabolic adaptations of the brain to acute respiratory acid-base disturbances, a method was developed to measure intracellular pH (pHi) in the brain of dogs under conditions in which arterial pH is rapidly altered. Brai... | [
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PMID:4980 | Myocardial CO2 buffering: role of transmembrane transport of H+ or HCO3-ions. | Isolated rabbit hearts were perfused with rabbit red cells suspended in Ringer solution. A small volume of perfusate was recirculated for 10 min at Pco2 of 33.4 +/- 0.9 or 150.8 +/- 7.5 mmHg. Hypercapnia resulted in an increase in perfusate HCO3- concentration that was smaller than that observed when isolated perfusate... | Myocardial CO2 buffering: role of transmembrane transport of H+ or HCO3-ions. Isolated rabbit hearts were perfused with rabbit red cells suspended in Ringer solution. A small volume of perfusate was recirculated for 10 min at Pco2 of 33.4 +/- 0.9 or 150.8 +/- 7.5 mmHg. Hypercapnia resulted in an increase in perfusate H... | [
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PMID:4981 | Cardiovascular effects of cerebroventricular ouabain perfusion in the adult dog. | Cerebroventricular perfusion with artificial cerebrospinal fluid containing 10(-5) M ouabain was performed in adult dogs in order to describe the time course of the cardiovascular effect of intraventricular ouabain and to evaluate treatments to eliminate the cardiovascular effect. The central effect of ouabain caused a... | Cardiovascular effects of cerebroventricular ouabain perfusion in the adult dog. Cerebroventricular perfusion with artificial cerebrospinal fluid containing 10(-5) M ouabain was performed in adult dogs in order to describe the time course of the cardiovascular effect of intraventricular ouabain and to evaluate treatmen... | [
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PMID:4982 | Effect of beta-adrenoreceptor blockade on rat cardiac and skeletal muscle pH. | The effect of catecholamines on the intracellular pH of rat cardiac and skeletal muscle during varying extracellular acid-base states was determined. Intracellualr pH (pHi) was calculated from the distribution of [14C]DMO. Acid-base disturbances were produced by placing the animals in an environmental chamber containin... | Effect of beta-adrenoreceptor blockade on rat cardiac and skeletal muscle pH. The effect of catecholamines on the intracellular pH of rat cardiac and skeletal muscle during varying extracellular acid-base states was determined. Intracellualr pH (pHi) was calculated from the distribution of [14C]DMO. Acid-base disturban... | [
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PMID:4983 | Biliary secretion in elasmobranchs. I. Bile collection and composition. | Bile composition and secretion were studied in tow elasmobranch species, Squalus acanthias (spiny dogfish shark) and Raja erinacea (small skate), after ligation of the common duct and insertion of cannulas into the gallbladder lumen. Fish were then allowed to swim freely in large pools and bile was collected in balloon... | Biliary secretion in elasmobranchs. I. Bile collection and composition. Bile composition and secretion were studied in tow elasmobranch species, Squalus acanthias (spiny dogfish shark) and Raja erinacea (small skate), after ligation of the common duct and insertion of cannulas into the gallbladder lumen. Fish were then... | [
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PMID:4984 | Film screening by physician assistants in diagnostic radiology. | Data are presented which indicate that specially selected ART students can be trained to evaluate radiographs as to the presence or absence of significant pathology with an accuracy equivalent to that of experienced staff radiologists. The methods employed in this training program-namely, stressing perceptual recogniti... | Film screening by physician assistants in diagnostic radiology. Data are presented which indicate that specially selected ART students can be trained to evaluate radiographs as to the presence or absence of significant pathology with an accuracy equivalent to that of experienced staff radiologists. The methods employed... | [
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PMID:4985 | Use of physician's assistants in a general surgical practice. | A study has been made of three PAS employed in a rural, small town, general surgical practice during a four year period. Their work was equally divided among three areas: minor trauma, obtaining and recording data for history and physical examinations, and assisting at routine surgical procedures and endoscopies. This ... | Use of physician's assistants in a general surgical practice. A study has been made of three PAS employed in a rural, small town, general surgical practice during a four year period. Their work was equally divided among three areas: minor trauma, obtaining and recording data for history and physical examinations, and a... | [
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PMID:4989 | [The influence of PaCO2 on oxygen consumption during extracorporeal circulation in hypothermia (author's transl)]. | Hypocapnia during extracorporeal circulation in hypothermia increases oxygen consumption. Po2 in mixed venous blood decreases. This probably reflects a decrease in tissue oxygen tension. Hyperventilation will therefore increase the risk of hypoxia in critically perfused tissues. Therefore we recommend to keep PaCO2 (T)... | [The influence of PaCO2 on oxygen consumption during extracorporeal circulation in hypothermia (author's transl)]. Hypocapnia during extracorporeal circulation in hypothermia increases oxygen consumption. Po2 in mixed venous blood decreases. This probably reflects a decrease in tissue oxygen tension. Hyperventilation w... | [
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PMID:4990 | [Clinical studies on the use of ketalar in obstetric anesthesia (author's transl)]. | 26 healthy pregnant women at term were divided into 2 groups and anaesthetized with either 1 mg/kh or 2 mg/kg ketamine - N20/02 - for primary caesarean section. Maternal venous ketamine plasma levels, neonatal ketamine plasma levels (umbilical artery and umbilical vein) and blood gases were measured. Maternal venous ke... | [Clinical studies on the use of ketalar in obstetric anesthesia (author's transl)]. 26 healthy pregnant women at term were divided into 2 groups and anaesthetized with either 1 mg/kh or 2 mg/kg ketamine - N20/02 - for primary caesarean section. Maternal venous ketamine plasma levels, neonatal ketamine plasma levels (um... | [
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PMID:4998 | Effect of abdominal compression on minute ventilation of patients with chronic obstructive lung disease and bronchial asthma. | The effects of manual compression of the upper lateral abdomen (C) of 73 cases of obstructive airway disease were studied in respect to the change in minute ventilation (V) 10 minutes after the procedure was performed. A mean decrease of 13% in V was found in the majority of 15 cases of bronchial asthma or chronic bron... | Effect of abdominal compression on minute ventilation of patients with chronic obstructive lung disease and bronchial asthma. The effects of manual compression of the upper lateral abdomen (C) of 73 cases of obstructive airway disease were studied in respect to the change in minute ventilation (V) 10 minutes after the ... | [
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PMID:5005 | [Accidental peroperative hypothermia during rapid transfusion]. | Six cases of grave hypothermias are reported, having arisen during surgical interventions which necessitated a rapid and abundant transfusion of badly warmed blood. The role of favouring factors, surrounding cold due to the air-conditioning, anaesthesia, extent of the area of operation, seems important. The symptomatol... | [Accidental peroperative hypothermia during rapid transfusion]. Six cases of grave hypothermias are reported, having arisen during surgical interventions which necessitated a rapid and abundant transfusion of badly warmed blood. The role of favouring factors, surrounding cold due to the air-conditioning, anaesthesia, e... | [
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PMID:5006 | [Information science in intensive care medicine. Examples of the European approach]. | The modern treatment of patients in a precarious state requires the use of technical appliances which become more complex and more numerous day by day. The data generated by these appliances, together with the conventional measurements of physiological parameters carried out by the nursing ataff during care, with the r... | [Information science in intensive care medicine. Examples of the European approach]. The modern treatment of patients in a precarious state requires the use of technical appliances which become more complex and more numerous day by day. The data generated by these appliances, together with the conventional measurements... | [
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PMID:5007 | [Iskedyl and general anesthesia. Measurement of the systolic ejection volume and peripheral resistance using the arterial pressure curves]. | ISKEDYL (PF 50), which is sold as a vasoregulator of cerebral irrigation, consists of a mixture of dihydroergocristine and raubasine. This work aims at determining possible interactions between this product and certain drugs used in anesthesia from the cardiovascular point of view. ISKEDYL does not seem to be a contrai... | [Iskedyl and general anesthesia. Measurement of the systolic ejection volume and peripheral resistance using the arterial pressure curves]. ISKEDYL (PF 50), which is sold as a vasoregulator of cerebral irrigation, consists of a mixture of dihydroergocristine and raubasine. This work aims at determining possible interac... | [
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PMID:5008 | [Continuous peridural anesthesia in traumatological and reparative surgery of the lower extremities]. | The authors give an account of their experience of peridural anaesthesia in 250 cases at the Centre for traumatological and reparative surgery. They demonstrate the advantages derived from this type of anaesthesia: in elderly subjects manifesting an organic defect, and in emergency cases with "full stomach". | [Continuous peridural anesthesia in traumatological and reparative surgery of the lower extremities]. The authors give an account of their experience of peridural anaesthesia in 250 cases at the Centre for traumatological and reparative surgery. They demonstrate the advantages derived from this type of anaesthesia: in ... | [
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PMID:5004 | [Disorders of body temperature regulation. 1. Physiopathological study]. | In this work, disorders of thermo-regulation are first studied in a synthetic manner from the angle of cellular and haemodynamic disturbances. Then the particular physiopathological aspects concerning hypothermia and hyperthermia are looked at in succession. In his next work, the author will view the clinical and thera... | [Disorders of body temperature regulation. 1. Physiopathological study]. In this work, disorders of thermo-regulation are first studied in a synthetic manner from the angle of cellular and haemodynamic disturbances. Then the particular physiopathological aspects concerning hypothermia and hyperthermia are looked at in ... | [
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PMID:5014 | [Physico-chemical characteristics, absorption and elimination kinetics and technics of use of enflurane]. | Physical-chemical properties, uptake und elemination of enflurane are described with particular references to halothane. The ratio potency/vapor pressure, the blood and tissues solubility of this agent provide a good flexibility of uptake and elemination in response to changes in alveolar ventilation. When used with ni... | [Physico-chemical characteristics, absorption and elimination kinetics and technics of use of enflurane]. Physical-chemical properties, uptake und elemination of enflurane are described with particular references to halothane. The ratio potency/vapor pressure, the blood and tissues solubility of this agent provide a go... | [
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PMID:5009 | [Impact of alfatesine anesthesia on cerebrospinal fluid pressure in man]. | The variations in pressure of the cerebrospinal fluid was studied in 20 patients before and after induction of anesthesia with alfatesine (0.1 ml/Kg). 14 patients received no other complementary drug (group 1); in the six other cases, 1 g. of acetylsalicylic acid was administered as an analgesic complement (group II). ... | [Impact of alfatesine anesthesia on cerebrospinal fluid pressure in man]. The variations in pressure of the cerebrospinal fluid was studied in 20 patients before and after induction of anesthesia with alfatesine (0.1 ml/Kg). 14 patients received no other complementary drug (group 1); in the six other cases, 1 g. of ace... | [
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PMID:5010 | [Transformation of sorbitol to mannitol when used in parenteral administration]. | This was shown by the unexpected discovery of the urinary excretion of mannitol when urinary sorbitol levels were being measured in connection with the surveillance of patients suffering from malnutrition and head injury and receiving total parenteral nutrition: glucose, sorbitol, amino-acids, soya oil. The presence of... | [Transformation of sorbitol to mannitol when used in parenteral administration]. This was shown by the unexpected discovery of the urinary excretion of mannitol when urinary sorbitol levels were being measured in connection with the surveillance of patients suffering from malnutrition and head injury and receiving tota... | [
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PMID:5015 | [Clinical evaluation of the new anesthetic "Ethrane"]. | Seventy-four patients aged 14 months to 71 years, classified as ASA I and II were anesthetised with Ethrane for surgical interventions of mean duration 117 minutes. With the exception of 5 patients who were directly anesthetised with Ethrane, the others received Ethrane after induction with Penthiobarbitone. Maintenanc... | [Clinical evaluation of the new anesthetic "Ethrane"]. Seventy-four patients aged 14 months to 71 years, classified as ASA I and II were anesthetised with Ethrane for surgical interventions of mean duration 117 minutes. With the exception of 5 patients who were directly anesthetised with Ethrane, the others received Et... | [
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PMID:5011 | [A case of acute tobacco poisoning by enema]. | The authors report the case of a 5 month old child intoxicated with nicotine through an enema. A mother who wished to treat her infant for constipation had administered to him as an enema a decoction of green tobacco leaves; 15 to 20 minutes after the enema, the child showed diarrhoea and respiratory disturbances. The ... | [A case of acute tobacco poisoning by enema]. The authors report the case of a 5 month old child intoxicated with nicotine through an enema. A mother who wished to treat her infant for constipation had administered to him as an enema a decoction of green tobacco leaves; 15 to 20 minutes after the enema, the child showe... | [
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PMID:5016 | [Hemodynamic effect of enflurane in man]. | The following hemodynamic parameters: cardiac frequency, peripheral arterial pressure, pulmonary pressure and cardiac output were measured by direct catheterisation, as the total peripheral vascular resistance and the systolic ejection volume were calculated from the registered results. The cardiac frequency and the pu... | [Hemodynamic effect of enflurane in man]. The following hemodynamic parameters: cardiac frequency, peripheral arterial pressure, pulmonary pressure and cardiac output were measured by direct catheterisation, as the total peripheral vascular resistance and the systolic ejection volume were calculated from the registered... | [
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PMID:5017 | [Postoperative circulatory arrest (apropos of 37 cases)]. | Within five years, the authors received 37 patients who had presented a post-operative cardiac arrest. Most of them came from the Bordeaux district (from the hospital as well as the public sector) although they did not represent the totality of such accidents. The study bears first of all upon the data concerning the p... | [Postoperative circulatory arrest (apropos of 37 cases)]. Within five years, the authors received 37 patients who had presented a post-operative cardiac arrest. Most of them came from the Bordeaux district (from the hospital as well as the public sector) although they did not represent the totality of such accidents. T... | [
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PMID:5018 | [New ventilation technic in anesthesia for direct suspension laryngoscopy]. | The authors bring not only the results of their experience but a solution of the respiratory problems during anaesthesia in suspension laryngoscopy, thanks to the devising of a new intubation probe and a pre-set automatic insufflator with varying volum flow. | [New ventilation technic in anesthesia for direct suspension laryngoscopy]. The authors bring not only the results of their experience but a solution of the respiratory problems during anaesthesia in suspension laryngoscopy, thanks to the devising of a new intubation probe and a pre-set automatic insufflator with varyi... | [
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PMID:5019 | [The second electromyographic study of surgical curarization with AH.8165, a new pachycurare derivative of azobis-arylimidazo(1-2a) pyridinium]. | This second electromyographic study of AH-8165, a product derived from azobis-arymilidazo-(1-2a) pyridinium, carried out with a special apparatus which both stimulates and records, specifies the characteristics of the neuro-muscular block induced by this new non-depolarizing type curarizing substance while taking into ... | [The second electromyographic study of surgical curarization with AH.8165, a new pachycurare derivative of azobis-arylimidazo(1-2a) pyridinium]. This second electromyographic study of AH-8165, a product derived from azobis-arymilidazo-(1-2a) pyridinium, carried out with a special apparatus which both stimulates and rec... | [
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PMID:5020 | [Contribution to the study of Trive 1000]. | A glucid-lipid and protein compound nutriment: Trive 1000 was administered to 53 patients during the first three postoperative days in varying doses: -1.000 ml per day to a first group -1.500 ml per day to a second group. The local tolerance was quite good. However, a few accidents of a general character were noted: th... | [Contribution to the study of Trive 1000]. A glucid-lipid and protein compound nutriment: Trive 1000 was administered to 53 patients during the first three postoperative days in varying doses: -1.000 ml per day to a first group -1.500 ml per day to a second group. The local tolerance was quite good. However, a few acci... | [
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PMID:5021 | [Comparative study of nitrogen savings during enteral and parenteral feeding (Trive 1000)]. | Through a study of Nitrogen balances, the authors compare the effectiveness of a proteinic intake carried out per os or by intravenous route. The study involved 22 different carcinoma carriers and lasted for 9 days during which the Nitrogen intake was effected either by the digestive tract or by intravenous route suppl... | [Comparative study of nitrogen savings during enteral and parenteral feeding (Trive 1000)]. Through a study of Nitrogen balances, the authors compare the effectiveness of a proteinic intake carried out per os or by intravenous route. The study involved 22 different carcinoma carriers and lasted for 9 days during which ... | [
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PMID:5022 | [The utilization of EB 51 in parenteral feeding. Clinical, biological and anatomopathological control. Statistical study on 30 patients]. | Two groups of patients (comas of central origin and serious digestive undernourished) were submitted to an exclusive or a supplementary parenteral feeding for a short or a long period of time totaling over 500 days. The catheter was placed (in 80 p. cent of the cases) in a deep vein and was tunnellized. EB 51 (Trivemil... | [The utilization of EB 51 in parenteral feeding. Clinical, biological and anatomopathological control. Statistical study on 30 patients]. Two groups of patients (comas of central origin and serious digestive undernourished) were submitted to an exclusive or a supplementary parenteral feeding for a short or a long perio... | [
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PMID:5026 | [Effect of increasing doses of dopamine on the left ventricular function in the dog]. | A study on eleven dogs of the effects of increasing doses of dopamine on the left ventricular function. A description of the method which consists of a venous shunt connected to an extra-corporeal circuit and which allows modification simply and rapidly of the state of vascular refilling of the animal. The results diff... | [Effect of increasing doses of dopamine on the left ventricular function in the dog]. A study on eleven dogs of the effects of increasing doses of dopamine on the left ventricular function. A description of the method which consists of a venous shunt connected to an extra-corporeal circuit and which allows modification... | [
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PMID:5027 | [The effect of intravenous dopamine on the hemodynamics of the heart]. | The pharmacological study of dopamine was conducted on 14 patients: eleven normal patients and three with incipient myocardiopathies. The dosages used were 3, 6 and 12 mug/kg/min. The "pump" function, the peripheral resistances, the contractility and the ventricular compliance were studied. Dopamine is a positive inotr... | [The effect of intravenous dopamine on the hemodynamics of the heart]. The pharmacological study of dopamine was conducted on 14 patients: eleven normal patients and three with incipient myocardiopathies. The dosages used were 3, 6 and 12 mug/kg/min. The "pump" function, the peripheral resistances, the contractility an... | [
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PMID:5028 | [Hemodynamic study of dopamine used in chronic heart failures and in cardiogenic shock as a complication of acute myocardial infarct]. | The object of this study is to examine the properties of dopamine at the hemodynamic and renal level in 16 patients with decompensated chronic cardiopathies or very serious cardiogenic shock due to myocardial infarction. The results show an increase in the cardiac index in 75 p. 100 of the cases with a favourable dimin... | [Hemodynamic study of dopamine used in chronic heart failures and in cardiogenic shock as a complication of acute myocardial infarct]. The object of this study is to examine the properties of dopamine at the hemodynamic and renal level in 16 patients with decompensated chronic cardiopathies or very serious cardiogenic ... | [
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0.07... |
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