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medium_convergence_02084 | GTF2B and ELL both interact with a shared protein partner. Evidence regarding this partner states: 'Analyses of the binding of this motif to other general transcription factors showed that the former class was defective in binding to the basic helix-loop-helix motif of TFIIEβ and the latter class was defective in bindi... | General transcription factor IIE subunit 1 | Medium | convergence | {"qa_id":"medium_convergence_02084","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2B and ELL both interact with a shared protein partner. Evidence regarding this partner states: 'Analyses of the binding of this motif to other general tr... | |
medium_convergence_02085 | The biological processes 'regulation of branching involved in mammary gland duct morphogenesis' and 'regulation of otic vesicle morphogenesis' share a common parent process. Evidence regarding this shared process states: 'Any process that modulates the rate, frequency, or extent of branching involved in mammary gland d... | morphogenesis of an epithelium | Medium | convergence | {"qa_id":"medium_convergence_02085","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The biological processes 'regulation of branching involved in mammary gland duct morphogenesis' and 'regulation of otic vesicle morphogenesis' share a common... | |
medium_convergence_02086 | Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) shows a log2 fold change of -1.187 and an adjusted p-value of 0.00324. Which protein is encoded by this gene? | Protein BTG2 | Medium | convergence | {"qa_id":"medium_convergence_02086","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Hepacivirus C are reported to downregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell li... | |
medium_convergence_02087 | AKT1 and MAPK8 share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation analysis revealed that endogenous Akt physically interacted with endogenous MAP2K4 in cells and that this interaction was promoted by insulin.' Which disease is associated with this specific i... | rheumatoid arthritis | Medium | convergence | {"qa_id":"medium_convergence_02087","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"AKT1 and MAPK8 share multiple interacting partners. One such partner is identified by evidence stating: 'Co-immunoprecipitation analysis revealed that endoge... | |
medium_convergence_02088 | NUDC and SUGT1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the essential outer-kinetochore protein SGT1 and stabilizes its protein levels. Which protein product is encoded by this shared protein? | PH domain leucine-rich repeat-containing protein phosphatase 1 | Medium | convergence | {"qa_id":"medium_convergence_02088","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUDC and SUGT1 both interact with a specific shared protein. Evidence indicates that this shared protein interacts with the essential outer-kinetochore prote... | |
medium_convergence_02089 | HSPA5 and MYC share multiple interacting partners. One of these shared partners is known to directly interact with c-Myc and stabilize its protein levels by preventing proteasomal degradation. Which disease is associated with this specific shared partner through genomic alterations? | hypercholesterolemia, familial, 4 | Medium | convergence | {"qa_id":"medium_convergence_02089","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HSPA5 and MYC share multiple interacting partners. One of these shared partners is known to directly interact with c-Myc and stabilize its protein levels by ... | |
medium_convergence_02090 | IFNA10 and IFNAR1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Quantitative single-molecule imaging of receptor assembly in the plasma membrane of living cells clearly identified IFN-induced dimerization of IFNAR1 and this shared entity.' Which protein is connected to... | Interferon alpha/beta receptor 2 | Medium | convergence | {"qa_id":"medium_convergence_02090","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IFNA10 and IFNAR1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Quantitative single-molecule imaging of re... | |
medium_convergence_02091 | PRKDC and NHEJ1 both interact with a shared protein entity. Evidence regarding this entity states: 'The DNA-dependent protein kinase (DNA-PK) controls the repair of double-stranded DNA breaks in mammalian cells. The protein kinase subunit of DNA-PK (DNA-PKcs) is targeted to DNA breaks by association with the Ku DNA-bin... | alcohol abuse | Medium | convergence | {"qa_id":"medium_convergence_02091","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKDC and NHEJ1 both interact with a shared protein entity. Evidence regarding this entity states: 'The DNA-dependent protein kinase (DNA-PK) controls the re... | |
medium_convergence_02092 | CREBBP and HDAC2 both interact with a specific shared protein. Experimental evidence for this shared protein indicates that an in vitro glutathione S-transferase (GST) pull-down assay revealed it strongly interacts with activating signal cointegrator (ASC)-2 and weakly with cyclic adenosine monophosphate responsive ele... | Heat shock factor protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02092","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and HDAC2 both interact with a specific shared protein. Experimental evidence for this shared protein indicates that an in vitro glutathione S-transfe... | |
medium_convergence_02093 | RANBP9 and HMG20B both interact with a shared protein. Evidence regarding this shared protein states: 'We also show that iBraf, a paralogue of Braf35, forms heterodimers with Braf35.' Which protein is encoded by the gene corresponding to this shared entity? | High mobility group protein 20A | Medium | convergence | {"qa_id":"medium_convergence_02093","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and HMG20B both interact with a shared protein. Evidence regarding this shared protein states: 'We also show that iBraf, a paralogue of Braf35, forms ... | |
medium_convergence_02094 | Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (from study GSE108897) indicates a log2 fold change of approximately -2.44 and an adjusted p-value of 0.00011. Which disease is associated with this gene via genomic alte... | tetralogy of fallot | Medium | convergence | {"qa_id":"medium_convergence_02094","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Dengue virus are known to downregulate a specific shared gene. Experimental data for this gene in macrophages (from s... | |
medium_convergence_02095 | SP1 and NCOR1 both interact with a shared protein. Evidence indicates that this shared protein interacts with SP1, binds to the p21(WAF1/Cip1) proximal promoter (which is rich in Sp1/Sp3 binding sites), and reduces histone H3 acetylation at this site. This activity suggests a key role for SP1 in the repression of p21(W... | Histone deacetylase 4 | Medium | convergence | {"qa_id":"medium_convergence_02095","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SP1 and NCOR1 both interact with a shared protein. Evidence indicates that this shared protein interacts with SP1, binds to the p21(WAF1/Cip1) proximal promo... | |
medium_convergence_02096 | NUP214 and NUPL1 share a common binding partner. Evidence indicates that both the FG-repeat domain of nucleoporin CAN/Nup214 and a novel human 15 kDa protein (p15) with homology to NTF2 (a nuclear transport factor which associates with RanGDP) directly bind to a nuclear export factor. Which protein is encoded by the ge... | Nuclear RNA export factor 1 | Medium | convergence | {"qa_id":"medium_convergence_02096","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NUP214 and NUPL1 share a common binding partner. Evidence indicates that both the FG-repeat domain of nucleoporin CAN/Nup214 and a novel human 15 kDa protein... | |
medium_convergence_02097 | ESR1 and POLR2E share a common interacting partner. Evidence regarding this shared partner states: 'Studies with extracts from TRAP220(-/-) fibroblasts reveal that these interactions depend on TRAP220, a TRAP/Mediator subunit previously shown to interact with ER and other nuclear receptors in a ligand-dependent manner.... | Mediator of RNA polymerase II transcription subunit 12 | Medium | convergence | {"qa_id":"medium_convergence_02097","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and POLR2E share a common interacting partner. Evidence regarding this shared partner states: 'Studies with extracts from TRAP220(-/-) fibroblasts revea... | |
medium_convergence_02098 | GIPC1 and ARHGAP32 each interact with more than one shared protein. Evidence concerning one shared entity reports that Grit was abundant in neuronal cells and directly interacted with a high-affinity receptor for nerve growth factor. Which protein is connected to that entity through the 'encodes' relationship? | High affinity nerve growth factor receptor | Medium | convergence | {"qa_id":"medium_convergence_02098","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GIPC1 and ARHGAP32 each interact with more than one shared protein. Evidence concerning one shared entity reports that Grit was abundant in neuronal cells an... | |
medium_convergence_02099 | CFL1 and NEDD4L share common interaction partners. One such partner is a beta-arrestin isoform that interacts with cofilin, LIMK, and chronophin, colocalizing with them in membrane protrusions to potentially spatially regulate their activities. Which cell type is this specific beta-arrestin isoform enriched in? | eosinophil | Medium | convergence | {"qa_id":"medium_convergence_02099","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CFL1 and NEDD4L share common interaction partners. One such partner is a beta-arrestin isoform that interacts with cofilin, LIMK, and chronophin, colocalizin... | |
medium_convergence_02100 | DNA2 and POLD2 both interact with a common protein partner. Evidence regarding this shared partner states: 'Using the two-hybrid system, we have mapped the interaction domains for binding to the p50 polymerase delta subunit and with PCNA to the N-terminus and the C-terminus of the protein encoded by this shared partner... | DNA polymerase delta subunit 3 | Medium | convergence | {"qa_id":"medium_convergence_02100","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNA2 and POLD2 both interact with a common protein partner. Evidence regarding this shared partner states: 'Using the two-hybrid system, we have mapped the i... | |
medium_convergence_02101 | EHMT2 and KDM1A share a common interacting partner. Evidence regarding this partner states: 'Strikingly, we found that this protein binds to both SUV39H1 and G9A histone methyl transferases, which provides a direct link between histone methylation and this protein at heterochromatic and euchromatic sites.' Which protei... | Zinc finger protein Gfi-1b | Medium | convergence | {"qa_id":"medium_convergence_02101","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and KDM1A share a common interacting partner. Evidence regarding this partner states: 'Strikingly, we found that this protein binds to both SUV39H1 and... | |
medium_convergence_02103 | Human immunodeficiency virus 1 and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene in natural killer cells reports a log2 fold change of approximately 1.602 and an adjusted p-value of 0.01575. Which biological process is this gene involved in? | regulation of RNA splicing | Medium | convergence | {"qa_id":"medium_convergence_02103","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human immunodeficiency virus 1 and Human mastadenovirus C both upregulate a specific gene. Evidence for this gene in natural killer cells reports a log2 fold... | |
medium_convergence_02104 | CTNNB1 and PRKN share multiple interacting partners. One such partner is implicated in a study demonstrating that cyclin-dependent kinase 2 (CDK2), in association with cyclin A or cyclin E, directly binds to beta-catenin. Which cellular component is this specific shared partner located in? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02104","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTNNB1 and PRKN share multiple interacting partners. One such partner is implicated in a study demonstrating that cyclin-dependent kinase 2 (CDK2), in associ... | |
medium_convergence_02105 | CDK2 and CLSPN share common binding partners. One such shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. Which disease is associated with this specific helicase subunit through genomic alterations? | Meier-Gorlin syndrome | Medium | convergence | {"qa_id":"medium_convergence_02105","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDK2 and CLSPN share common binding partners. One such shared partner is a DNA helicase subunit whose interaction with Claspin is lost upon Cdc7 inhibition. ... | |
medium_convergence_02106 | Insulin lispro and topical calcitriol share interactions with multiple drugs. One shared interacting agent is supported by evidence stating: 'The combination of hormone replacement therapy/estrogen replacement therapy + calcitriol increased bone mineral density 3.80% (+/-4.95%) at the femoral neck (P < 0.001), 4.91% (+... | postmenopausal osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_02106","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Insulin lispro and topical calcitriol share interactions with multiple drugs. One shared interacting agent is supported by evidence stating: 'The combination... | |
medium_convergence_02107 | SH3KBP1 and YWHAG both interact with a specific shared protein. Evidence regarding this shared entity states: 'Yeast two-hybrid screening of a p53(-/-) astrocyte cDNA library with this SH3 domain identified a novel gene, SETA binding protein 1, with 55% amino acid identity to the renal tumor antigen, NY-REN-45.' Which ... | SH3KBP1-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02107","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SH3KBP1 and YWHAG both interact with a specific shared protein. Evidence regarding this shared entity states: 'Yeast two-hybrid screening of a p53(-/-) astro... | |
medium_convergence_02108 | PES1 and SENP3 both interact with a specific protein that is a component of the PeBoW complex. Evidence indicates that mutant M1 and M5 proteins associate with large pre-ribosomal complexes and co-immunoprecipitate with Bop1 and this specific protein, confirming its proper incorporation into the PeBoW complex. Which pr... | Ribosome biogenesis protein WDR12 | Medium | convergence | {"qa_id":"medium_convergence_02108","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PES1 and SENP3 both interact with a specific protein that is a component of the PeBoW complex. Evidence indicates that mutant M1 and M5 proteins associate wi... | |
medium_convergence_02109 | Rhinovirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold change of -2.271 and an adjusted p-value of 0.008174. Which cell type is this gene enriched in? | mucosal-associated invariant T cell | Medium | convergence | {"qa_id":"medium_convergence_02109","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Primate bocaparvovirus 1 both downregulate a specific gene. Experimental data for this gene in cytotoxic T-lymphocytes shows a log2 fold cha... | |
medium_convergence_02110 | DNA2 and BLM both interact with a specific shared protein. Evidence indicates that BRCA1 and BLM interact with this shared protein predominantly in S- and G2-phases, respectively. Which protein is encoded by the gene corresponding to this shared entity? | DNA repair protein RAD50 | Medium | convergence | {"qa_id":"medium_convergence_02110","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DNA2 and BLM both interact with a specific shared protein. Evidence indicates that BRCA1 and BLM interact with this shared protein predominantly in S- and G2... | |
medium_convergence_02111 | EGFR and PTK2 both interact with a shared protein. Evidence indicates that this protein is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 cells by EGFRvIII. Which cell type is enriched in this shared protein? | natural killer cell | Medium | convergence | {"qa_id":"medium_convergence_02111","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EGFR and PTK2 both interact with a shared protein. Evidence indicates that this protein is recruited to EGFRvIII and inhibits the transformation of NIH 3T3 c... | |
medium_convergence_02112 | FKBP5 and HSP90AA1 share multiple interacting partners. One such shared partner is characterized by evidence stating that it specifically interacts with HSP90-1beta, HSC70, and HSP70 proteins, an association required for its kinase activity. Which gene does this specific shared partner interact with? | CCT6A | Medium | convergence | {"qa_id":"medium_convergence_02112","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FKBP5 and HSP90AA1 share multiple interacting partners. One such shared partner is characterized by evidence stating that it specifically interacts with HSP9... | |
medium_convergence_02113 | Human betaherpesvirus 5 and Dengue virus both upregulate a specific gene. Experimental evidence for this shared target indicates a log2 fold change of 1.316 and an adjusted p-value of 7.185e-07. Which protein is encoded by this gene? | Zinc finger protein 665 | Medium | convergence | {"qa_id":"medium_convergence_02113","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Dengue virus both upregulate a specific gene. Experimental evidence for this shared target indicates a log2 fold change of 1.316 ... | |
medium_convergence_02114 | Human respirovirus 3 and Dengue virus both downregulate a specific gene. Evidence for this shared target in non-small cell lung adenocarcinoma cells (study GSE147507) reports a log2 fold change of approximately -1.167 and an adjusted p-value of 0.04685. Which protein is encoded by this gene? | SAM and SH3 domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02114","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human respirovirus 3 and Dengue virus both downregulate a specific gene. Evidence for this shared target in non-small cell lung adenocarcinoma cells (study G... | |
medium_convergence_02115 | ATR and RPA3 share multiple binding partners. One such shared partner is involved in a complex with HCLK2, ATR-ATRIP, and an ATR activator. Which protein is encoded by this shared partner? | DNA topoisomerase 2-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02115","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATR and RPA3 share multiple binding partners. One such shared partner is involved in a complex with HCLK2, ATR-ATRIP, and an ATR activator. Which protein is ... | |
medium_convergence_02116 | ALK and NEDD4 both interact with a specific adaptor protein. Evidence indicates that this adaptor protein is a novel binding partner of NEDD4-1 and plays important roles in controlling PTEN ubiquitination by regulating NEDD4-1 activity and the association between PTEN and NEDD4-1. Which protein is encoded by the gene c... | Protein numb homolog | Medium | convergence | {"qa_id":"medium_convergence_02116","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ALK and NEDD4 both interact with a specific adaptor protein. Evidence indicates that this adaptor protein is a novel binding partner of NEDD4-1 and plays imp... | |
medium_convergence_02117 | HDAC6 and CSNK2A1 both interact with a shared protein partner. Evidence for the interaction with one specific partner states: 'The interaction between these proteins has been confirmed by co-immunoprecipitation, confocal immunofluorescence microscopy, and by density gradient separation of protein complexes.' Which prot... | Heat shock protein beta-1 | Medium | convergence | {"qa_id":"medium_convergence_02117","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC6 and CSNK2A1 both interact with a shared protein partner. Evidence for the interaction with one specific partner states: 'The interaction between these ... | |
medium_convergence_02118 | MAP4K1 and PPP2R1A share multiple interaction partners. One such shared partner is described in evidence stating that HPK1 interacts with this partner in a TCR stimulation-dependent manner and phosphorylates the linker region of this partner. Which cell type is enriched for this shared partner? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02118","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAP4K1 and PPP2R1A share multiple interaction partners. One such shared partner is described in evidence stating that HPK1 interacts with this partner in a T... | |
medium_convergence_02119 | DAB1 and FYN both interact with a shared intracellular adaptor protein. Evidence indicates that signaling through specific cell surface receptors requires the interaction of their cytoplasmic tails with this adaptor protein, identified as Disabled-1. Which protein is connected to Disabled-1 through the 'encodes' relati... | Low-density lipoprotein receptor-related protein 8 | Medium | convergence | {"qa_id":"medium_convergence_02119","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAB1 and FYN both interact with a shared intracellular adaptor protein. Evidence indicates that signaling through specific cell surface receptors requires th... | |
medium_convergence_02120 | EP300 and HIF1A share a common interaction partner that is a core component of the chaperone-mediated autophagy (CMA) machinery, specifically interacting with HSC70. Which disease is associated with this shared entity through genomic alterations? | Danon disease | Medium | convergence | {"qa_id":"medium_convergence_02120","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and HIF1A share a common interaction partner that is a core component of the chaperone-mediated autophagy (CMA) machinery, specifically interacting wit... | |
medium_convergence_02122 | RNF181 and PEX5 both interact with a common protein partner. Evidence regarding one such partner states: 'We identified RNF181 as an E3 ligase that interacts with the E2 enzyme [Partner].' Which protein is encoded by this specific partner? | Ubiquitin-conjugating enzyme E2 D2 | Medium | convergence | {"qa_id":"medium_convergence_02122","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF181 and PEX5 both interact with a common protein partner. Evidence regarding one such partner states: 'We identified RNF181 as an E3 ligase that interacts... | |
medium_convergence_02123 | Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE114966) reports a log2 fold change of approximately 1.036 and an adjusted p-value of 0.005641. Which protein is encoded by this gene? | TLC domain-containing protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02123","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human alphaherpesvirus 1 and Cardiovirus A both upregulate a specific gene. Experimental data for this gene in a monocytic leukemia cell line (study GSE11496... | |
medium_convergence_02124 | TP73 and UBE2D2 both interact with a specific shared protein. Experimental evidence indicates that UBE2D2, but not other E2 enzymes tested, specifically binds to the catalytic domain of this shared protein and promotes its catalyzed ubiquitin chain formation. Which protein product is encoded by this shared protein? | Ubiquitin-protein ligase E3C | Medium | convergence | {"qa_id":"medium_convergence_02124","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TP73 and UBE2D2 both interact with a specific shared protein. Experimental evidence indicates that UBE2D2, but not other E2 enzymes tested, specifically bind... | |
medium_convergence_02125 | BRCA1 and BRCC3 both interact with a shared protein. Evidence indicates that this shared protein possesses a COOH-terminal HECT-containing domain that interacts with an NH(2)-terminal degron domain in BRCA1. Which cell type is this shared protein enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02125","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BRCA1 and BRCC3 both interact with a shared protein. Evidence indicates that this shared protein possesses a COOH-terminal HECT-containing domain that intera... | |
medium_convergence_02126 | GSK3B and HDAC1 share multiple interacting partners. One such partner is described in evidence stating: 'Nondenaturing co-IP assays indicate that nuclear Bcl-3 associates with STAT-1 and histone deacetylase 1 (HDAC-1), increasing HDAC-1 recruitment to the IL-8 promoter.' Which protein is encoded by the gene correspondi... | B-cell lymphoma 3 protein | Medium | convergence | {"qa_id":"medium_convergence_02126","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GSK3B and HDAC1 share multiple interacting partners. One such partner is described in evidence stating: 'Nondenaturing co-IP assays indicate that nuclear Bcl... | |
medium_convergence_02128 | GTF2B and H3C1 share multiple binding partners. One shared partner is supported by evidence stating: 'Immunoprecipitation assay and GST pull down demonstrated that a histone acetyltransferase could interact directly with H3 in osteosarcoma cancer cells.' Which protein is connected to this shared partner through the 'en... | Histone acetyltransferase KAT2B | Medium | convergence | {"qa_id":"medium_convergence_02128","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2B and H3C1 share multiple binding partners. One shared partner is supported by evidence stating: 'Immunoprecipitation assay and GST pull down demonstrate... | |
medium_convergence_02129 | CDT1 and CDC7 both interact with a specific protein component of the MCM complex. Evidence indicates that poly-ubiquitination of Geminin prevents DNA replication over-firing by indirectly blocking the association of Cdt1 with this MCM protein complex, an interaction required for DNA unwinding and replication. Which pro... | DNA replication licensing factor MCM2 | Medium | convergence | {"qa_id":"medium_convergence_02129","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CDT1 and CDC7 both interact with a specific protein component of the MCM complex. Evidence indicates that poly-ubiquitination of Geminin prevents DNA replica... | |
medium_convergence_02130 | EP300 and TRIM33 both interact with a specific shared protein. Experimental evidence indicates that p300 coimmunoprecipitates with this protein in extracts from murine erythroleukemia (MEL) cells induced to differentiate with dimethylsulfoxide (DMSO), and that p300 and this protein are found together in a common E box ... | leukemia, acute lymphocytic, susceptibility to, 1 | Medium | convergence | {"qa_id":"medium_convergence_02130","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EP300 and TRIM33 both interact with a specific shared protein. Experimental evidence indicates that p300 coimmunoprecipitates with this protein in extracts f... | |
medium_convergence_02131 | IL12A and C1QBP are both involved in more than one shared biological process. Evidence indicates that IL12 significantly enhances the adhesion and subsequent migration of NK cells through 3-micron-pore-size polycarbonate filters. Which biological process, connected to the entity described in this evidence via a 'positi... | cell adhesion | Medium | convergence | {"qa_id":"medium_convergence_02131","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"IL12A and C1QBP are both involved in more than one shared biological process. Evidence indicates that IL12 significantly enhances the adhesion and subsequent... | |
medium_convergence_02132 | ESR1 and HDAC1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for the interaction with this partner, the suppression of ER by this partner could be reversed, suggesting that this suppression is confer... | negative regulation of transcription by RNA polymerase II | Medium | convergence | {"qa_id":"medium_convergence_02132","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ESR1 and HDAC1 share multiple interacting partners. One such partner is characterized by evidence stating: 'Utilizing an interaction blocker, ER-6 (amino aci... | |
medium_convergence_02133 | HNRNPA1 and MYC both interact with a shared protein. Evidence for one such shared partner states: 'In in vitro pull-down assays, HAP interacts with hnRNP A1, through its S/K-R/E-rich region, and with several other hnRNPs.' Which disease is genetically associated with this specific shared partner? | cervical cancer | Medium | convergence | {"qa_id":"medium_convergence_02133","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HNRNPA1 and MYC both interact with a shared protein. Evidence for one such shared partner states: 'In in vitro pull-down assays, HAP interacts with hnRNP A1,... | |
medium_convergence_02134 | RACK1 (GNB2L1) and SNRNP27 share interaction partners. One such shared partner is a deubiquitinating enzyme whose cellular interaction partners were analyzed via co-immunoprecipitation and MS/MS. These experiments demonstrated that FUS (also known as TLS or CHOP) and RACK1 are part of complexes containing this enzyme, ... | Ubiquitin thioesterase OTUB1 | Medium | convergence | {"qa_id":"medium_convergence_02134","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 (GNB2L1) and SNRNP27 share interaction partners. One such shared partner is a deubiquitinating enzyme whose cellular interaction partners were analyzed... | |
medium_convergence_02135 | FLNA and IKBKB each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Additional yeast two-hybrid assays indicated that filamin A specifically interacts with the p73alpha C-terminus, which is lacking in p53 and p73beta.' Which protein is encoded by that entity? | Tumor protein p73 | Medium | convergence | {"qa_id":"medium_convergence_02135","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FLNA and IKBKB each interact with more than one shared gene product. Evidence concerning one shared entity reports: 'Additional yeast two-hybrid assays indic... | |
medium_convergence_02136 | RACK1 and HSPA1A share common interacting partners. One such shared partner is characterized by evidence stating that phosphorylation at Thr50 enhances its direct binding to Vps15, Atg14L, and Beclin 1, thereby promoting the assembly of the autophagy-initiation complex. Which protein is encoded by the gene correspondin... | Phosphatidylinositol 3-kinase catalytic subunit type 3 | Medium | convergence | {"qa_id":"medium_convergence_02136","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RACK1 and HSPA1A share common interacting partners. One such shared partner is characterized by evidence stating that phosphorylation at Thr50 enhances its d... | |
medium_convergence_02137 | Both Human alphaherpesvirus 1 and Human gammaherpesvirus 4 are known to downregulate a specific shared gene. Experimental data from a monocytic leukemia cell line (study GSE114966) indicates that this gene exhibits a log2 fold change of approximately -1.016 and an adjusted p-value of 0.003743. Which protein is encoded ... | Dual specificity protein phosphatase 4 | Medium | convergence | {"qa_id":"medium_convergence_02137","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human alphaherpesvirus 1 and Human gammaherpesvirus 4 are known to downregulate a specific shared gene. Experimental data from a monocytic leukemia cell... | |
medium_convergence_02138 | Interferon beta-1a and Methotrexate share a common drug interaction partner. Evidence regarding one such partner states: 'The phosphorylation of 3TC was significantly increased in the presence of either hydroxyurea (HU), methotrexate (MTX), or fludarabine (FLU).' Which disease is this shared entity indicated for? | HIV infectious disease | Medium | convergence | {"qa_id":"medium_convergence_02138","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Interferon beta-1a and Methotrexate share a common drug interaction partner. Evidence regarding one such partner states: 'The phosphorylation of 3TC was sign... | |
medium_convergence_02139 | NFKB1 and SFPQ both interact with a shared gene product. Experimental evidence indicates that this shared entity, when tyrosine-phosphorylated, directly binds to NF-kappaB in vitro and in vivo, as demonstrated by glutathione S-transferase pulldown assays and coimmunoprecipitation. Which disease is associated with this ... | urinary tract obstruction | Medium | convergence | {"qa_id":"medium_convergence_02139","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NFKB1 and SFPQ both interact with a shared gene product. Experimental evidence indicates that this shared entity, when tyrosine-phosphorylated, directly bind... | |
medium_convergence_02140 | CSNK2A1 and BTRC both interact with a shared protein entity. Evidence regarding this entity states: 'We demonstrate here that the Ring-H2 finger-disrupted mutant of this entity does not interact with purified CKIIbeta in vitro, which shows that the Ring-H2 finger motif is critical for direct interaction with CKIIbeta.'... | RING-box protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02140","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CSNK2A1 and BTRC both interact with a shared protein entity. Evidence regarding this entity states: 'We demonstrate here that the Ring-H2 finger-disrupted mu... | |
medium_convergence_02141 | SLC8B1 and MCU are both involved in more than one shared biological process. Evidence concerning one shared entity reports: 'Mitochondrial calcium accumulation was recently shown to depend on a complex composed of an inner-membrane channel (MCU and MCUb) and regulatory subunits (MICU1, MCUR1, and EMRE).' Which biologic... | calcium ion transmembrane transport | Medium | convergence | {"qa_id":"medium_convergence_02141","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SLC8B1 and MCU are both involved in more than one shared biological process. Evidence concerning one shared entity reports: 'Mitochondrial calcium accumulati... | |
medium_convergence_02142 | GEMIN5 and MAP3K1 both interact with a specific shared protein. Experimental evidence indicates that this shared protein physically interacts with ASK1, as well as with the downstream kinases SEK1 and a c-Jun NH(2)-terminal kinase, and that it potentiates the H(2)O(2)-induced activation of these kinases in intact cells... | Mitogen-activated protein kinase 8 | Medium | convergence | {"qa_id":"medium_convergence_02142","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GEMIN5 and MAP3K1 both interact with a specific shared protein. Experimental evidence indicates that this shared protein physically interacts with ASK1, as w... | |
medium_convergence_02143 | CREBBP and EP300 both interact with a specific gene product. Evidence indicates that this product, a B-type myb proto-oncogene, is acetylated by the co-activator p300. Which disease is associated with this gene product through genomic alterations? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_02143","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CREBBP and EP300 both interact with a specific gene product. Evidence indicates that this product, a B-type myb proto-oncogene, is acetylated by the co-activ... | |
medium_convergence_02144 | PSMA4 and PSMB2 both interact with a shared protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subunit beta2 is required for beta2's interaction with adjacent beta3, whereas the C-terminal extension of immunosubunit beta2i is dispensable for beta2i's interaction ... | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02144","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PSMA4 and PSMB2 both interact with a shared protein partner. Evidence regarding this partner states: 'For example, the C-terminal extension of standard subun... | |
medium_convergence_02145 | Both ADRB2 and ARRB2 interact with a specific deubiquitinating enzyme. Evidence indicates that this enzyme, identified as ubiquitin-specific protease 33, binds to beta-arrestin2 and facilitates the deubiquitination of beta-arrestins. Which protein product is encoded by the gene corresponding to this enzyme? | Ubiquitin carboxyl-terminal hydrolase 33 | Medium | convergence | {"qa_id":"medium_convergence_02145","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both ADRB2 and ARRB2 interact with a specific deubiquitinating enzyme. Evidence indicates that this enzyme, identified as ubiquitin-specific protease 33, bin... | |
medium_convergence_02147 | FBP1 and KRAS share common interaction partners. One such shared partner has been experimentally demonstrated to bind FBP1 in breast cancer cells. Which protein is encoded by this shared interaction partner? | Neurogenic locus notch homolog protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02147","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"FBP1 and KRAS share common interaction partners. One such shared partner has been experimentally demonstrated to bind FBP1 in breast cancer cells. Which prot... | |
medium_convergence_02148 | RNF167 and PRKN (PARK2) share common interacting partners. One such shared partner is described by the following evidence: 'We found that this protein interacted with ring finger protein 167 (RNF167) through its C-terminal coupling of ubiquitin to ER degradation (CUE) domain.' Which protein is encoded by this shared in... | Toll-interacting protein | Medium | convergence | {"qa_id":"medium_convergence_02148","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RNF167 and PRKN (PARK2) share common interacting partners. One such shared partner is described by the following evidence: 'We found that this protein intera... | |
medium_convergence_02149 | ANAPC2 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Both APC11 and a ubiquitin-conjugating enzyme bind to the C-terminal cullin homology domain of APC2, whereas Ubc4 interacts with APC11 directly.' Which protein is connected to that entity through the 'encod... | Ubiquitin-conjugating enzyme E2 C | Medium | convergence | {"qa_id":"medium_convergence_02149","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC2 and BUB1B each interact with more than one shared protein. Evidence concerning one shared entity reports: 'Both APC11 and a ubiquitin-conjugating enzy... | |
medium_convergence_02150 | GRIN1 and GRIN2B both physically interact with a specific shared protein partner. Experimental evidence indicates that immunoprecipitation using an anti-NR1 antibody reveals that the majority of NR3A associates with NR1 in the postnatal day 10 rat cortex (80 +/- 8%), a level that decreases by half (38 +/- 4%) in the ad... | PTPA | Medium | convergence | {"qa_id":"medium_convergence_02150","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN1 and GRIN2B both physically interact with a specific shared protein partner. Experimental evidence indicates that immunoprecipitation using an anti-NR1 ... | |
medium_convergence_02151 | CPLX1 and RAB3A each interact with more than one shared protein partner. Evidence concerning one shared entity reports that Complexin binds in an antiparallel alpha-helical conformation to the groove between the synaptobrevin and syntaxin helices. Which protein is connected to that entity through the 'encodes' relation... | Synaptosomal-associated protein 25 | Medium | convergence | {"qa_id":"medium_convergence_02151","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CPLX1 and RAB3A each interact with more than one shared protein partner. Evidence concerning one shared entity reports that Complexin binds in an antiparalle... | |
medium_convergence_02152 | SMAD7 and RPS27A both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Similar to Smurfs, the protein associated with Smad7 and induced its nuclear export, and enhanced binding of Smad7 to TGF-beta type I receptor to cause ubiquitination and degradation of the receptor.' Whi... | NEDD4-like E3 ubiquitin-protein ligase WWP1 | Medium | convergence | {"qa_id":"medium_convergence_02152","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SMAD7 and RPS27A both interact with a specific protein. Evidence regarding this shared interaction partner states: 'Similar to Smurfs, the protein associated... | |
medium_convergence_02153 | MAPK1 and MAPK9 share a common interacting partner. Evidence regarding this partner indicates that full-length MAP2K7 with combined D1/D2 mutations showed compromised binding to JNK1 and reduced JNK1 kinase activity compared to wild-type MAP2K7. Which disease is associated with this interacting partner? | colon adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_02153","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"MAPK1 and MAPK9 share a common interacting partner. Evidence regarding this partner indicates that full-length MAP2K7 with combined D1/D2 mutations showed co... | |
medium_convergence_02155 | EIF3F and EIF3G each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and inactivation of cif-1 impairs translation in vivo.' Which protein is encoded by the gene corresponding to that shared entity? | Eukaryotic translation initiation factor 3 subunit M | Medium | convergence | {"qa_id":"medium_convergence_02155","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EIF3F and EIF3G each interact with more than one shared protein partner. Evidence concerning one such shared entity states: 'Indeed, CIF-1 binds eIF-3.F and ... | |
medium_convergence_02156 | ATM and NFIX share common interacting partners. One such shared partner is a protein whose N-terminal domain is vital for its interaction with ATM, a process that occurs independently of the DNA damage state. Which gene encodes this specific shared interacting protein? | E1A-binding protein p400 | Medium | convergence | {"qa_id":"medium_convergence_02156","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ATM and NFIX share common interacting partners. One such shared partner is a protein whose N-terminal domain is vital for its interaction with ATM, a process... | |
medium_convergence_02157 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this gene has a log2 fold change of approximately -2.60 and an adjusted p-value of 0.00126. Which protein is encoded by this gene? | Actin, alpha cardiac muscle 1 | Medium | convergence | {"qa_id":"medium_convergence_02157","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data from a study on rhabdomyosarcoma cells (GSE103308) indicates that this ge... | |
medium_convergence_02158 | Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T-lymphocytes reports a log2 fold change of approximately 3.48 and an adjusted p-value of 0.0309. Which cell type is this gene enriched in? | neutrophil | Medium | convergence | {"qa_id":"medium_convergence_02158","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human orthopneumovirus and Human immunodeficiency virus 1 are known to upregulate a specific shared gene. Experimental data for this gene in cytotoxic T... | |
medium_convergence_02159 | Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of approximately 1.117 and an adjusted p-value of 1.024e-05. In which cellular component is this gene product located? | nucleus | Medium | convergence | {"qa_id":"medium_convergence_02159","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both upregulate a specific gene. Experimental evidence for this gene shows a log2 fold change of approximately 1.117 and an ad... | |
medium_convergence_02160 | CTBP1 and AHR share a common interaction partner. Evidence regarding this partner states: 'Using glutathione S-transferase (GST) "pull-down" binding assays, we have mapped a major interaction between these factors to the silencing domain of the shared protein and the PAS B ligand binding domain of the shared protein, a... | Nuclear receptor corepressor 2 | Medium | convergence | {"qa_id":"medium_convergence_02160","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CTBP1 and AHR share a common interaction partner. Evidence regarding this partner states: 'Using glutathione S-transferase (GST) \"pull-down\" binding assays... | |
medium_convergence_02161 | RANBP9 and COPS5 both interact with a shared gene product. Experimental evidence indicates that RanBPM constitutively associates with the mu-opioid receptor in HEK293 cells via co-immunoprecipitation. Which disease is associated with this shared entity? | diabetes mellitus | Medium | convergence | {"qa_id":"medium_convergence_02161","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"RANBP9 and COPS5 both interact with a shared gene product. Experimental evidence indicates that RanBPM constitutively associates with the mu-opioid receptor ... | |
medium_convergence_02163 | SIN3A and HDAC1 share a common interacting partner. Evidence indicates that this partner interacts with histone methyltransferase (PRC2) and histone deacetylase (NuRD and SIN3A) complexes through their common subunit, RBBP4/7. Which disease is associated with this entity? | Dias-Logan syndrome | Medium | convergence | {"qa_id":"medium_convergence_02163","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"SIN3A and HDAC1 share a common interacting partner. Evidence indicates that this partner interacts with histone methyltransferase (PRC2) and histone deacetyl... | |
medium_convergence_02164 | Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 2.617 and an adjusted p-value of 0.03824. Which protein is encoded by this gene? | Growth-regulated alpha protein | Medium | convergence | {"qa_id":"medium_convergence_02164","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Rhinovirus A and Cardiovirus A both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 2.61... | |
medium_convergence_02165 | BMP5 and BMPR1B both interact with a common receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. Which disease is causally linked to this specific receptor? | portal hypertension | Medium | convergence | {"qa_id":"medium_convergence_02165","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BMP5 and BMPR1B both interact with a common receptor. Evidence indicates this receptor is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 ... | |
medium_convergence_02167 | Hepacivirus C and Dengue virus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 2.165 and an adjusted p-value of 0.01736. Which cell type is this gene enriched in? | plasmacytoid dendritic cell | Medium | convergence | {"qa_id":"medium_convergence_02167","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Hepacivirus C and Dengue virus both upregulate a specific gene. Evidence for this gene in a particular study reports a log2 fold change of approximately 2.16... | |
medium_convergence_02168 | ANAPC2 and ANAPC4 each interact with more than one shared partner. Evidence concerning one shared partner reports that the carboxy-terminal tail of Emi1 antagonizes chain elongation by this entity, by competitively preventing its binding to the APC cullin subunit through electrostatic interaction. Which cellular compon... | anaphase-promoting complex | Medium | convergence | {"qa_id":"medium_convergence_02168","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ANAPC2 and ANAPC4 each interact with more than one shared partner. Evidence concerning one shared partner reports that the carboxy-terminal tail of Emi1 anta... | |
medium_convergence_02169 | CBFB and HDAC4 both interact with a specific transcription factor. Evidence indicates that HDAC4 interacts with this factor, binds the MMP-13 promoter, and suppresses MMP-13 gene transcription in the rat osteoblastic cell line UMR 106-01. Which protein is encoded by this transcription factor? | Runt-related transcription factor 2 | Medium | convergence | {"qa_id":"medium_convergence_02169","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CBFB and HDAC4 both interact with a specific transcription factor. Evidence indicates that HDAC4 interacts with this factor, binds the MMP-13 promoter, and s... | |
medium_convergence_02170 | HRAS and BRAP share multiple binding partners. One such shared partner is known to interact with BRCA1-associated protein 2, thereby inhibiting the ERK signal transduction cascade. Which disease is associated with this specific shared partner? | squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_02170","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HRAS and BRAP share multiple binding partners. One such shared partner is known to interact with BRCA1-associated protein 2, thereby inhibiting the ERK signa... | |
medium_convergence_02171 | EHMT2 and HDAC1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that in the ovary, this entity interacted with NuRD proteins CHD4 and HDAC1, as well as the core cohesin complex protein RAD21. Which protein is encoded by that entity? | Metastasis-associated protein MTA3 | Medium | convergence | {"qa_id":"medium_convergence_02171","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"EHMT2 and HDAC1 each interact with more than one shared protein partner. Evidence concerning one of these shared partners reports that in the ovary, this ent... | |
medium_convergence_02172 | ERBB2 and ERBB3 share multiple binding partners. One such partner is a ligand whose EGF-like domain binds to domains I and II of HER3. Which disease is associated with this ligand through genomic alterations? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_02172","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ERBB2 and ERBB3 share multiple binding partners. One such partner is a ligand whose EGF-like domain binds to domains I and II of HER3. Which disease is assoc... | |
medium_convergence_02173 | ITCH and CASP8 both interact with a shared protein. Evidence indicates that TAX1BP1 recruits the E3 ligase ITCH to this shared protein to trigger its ubiquitination and degradation, and that loss of either TAX1BP1 or ITCH leads to increased expression of this shared protein. Which protein is encoded by the gene corresp... | Mitochondrial antiviral-signaling protein | Medium | convergence | {"qa_id":"medium_convergence_02173","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ITCH and CASP8 both interact with a shared protein. Evidence indicates that TAX1BP1 recruits the E3 ligase ITCH to this shared protein to trigger its ubiquit... | |
medium_convergence_02174 | ISL2 and YY1 both interact with a specific transcription factor. Evidence regarding this factor states: 'Although the interaction between most LIM homeodomain proteins is dependent on NLI, a direct interaction between the LIM domains of this factor and the homeodomains of Isl1 and Isl2 was also observed.' Which disease... | non-acquired combined pituitary hormone deficiency with spine abnormalities | Medium | convergence | {"qa_id":"medium_convergence_02174","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ISL2 and YY1 both interact with a specific transcription factor. Evidence regarding this factor states: 'Although the interaction between most LIM homeodomai... | |
medium_convergence_02175 | Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Evidence for this gene shows a log2 fold change of 1.563 and an adjusted p-value of 0.04004. Which disease is associated with this gene as a biomarker? | adult lymphoma | Medium | convergence | {"qa_id":"medium_convergence_02175","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Human betaherpesvirus 5 and Human orthopneumovirus both upregulate a specific gene. Evidence for this gene shows a log2 fold change of 1.563 and an adjusted ... | |
medium_convergence_02177 | GRIN1 and CAMK2A each interact with more than one shared protein partner. Evidence concerning one shared entity reports that Neto1(HA) was shown to co-immunoprecipitate with assembled NMDA receptors via GluN2A or a specific GluN2 subunit, whereas Neto1(HA) did not co-immunoprecipitate with APP695(FLAG). Which disease i... | fetal growth restriction | Medium | convergence | {"qa_id":"medium_convergence_02177","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GRIN1 and CAMK2A each interact with more than one shared protein partner. Evidence concerning one shared entity reports that Neto1(HA) was shown to co-immuno... | |
medium_convergence_02178 | DAG1 and CDC42 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it binds strongly to GTP-Cdc42 and weakly to GTP-Rac. Which protein is encoded by the gene corresponding to this shared entity? | Serine/threonine-protein kinase PAK 6 | Medium | convergence | {"qa_id":"medium_convergence_02178","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DAG1 and CDC42 each interact with more than one shared protein. Evidence concerning one of these shared proteins indicates that it binds strongly to GTP-Cdc4... | |
medium_convergence_02179 | Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately -1.69 and an adjusted p-value of approximately 0.0115. Which disease is associated with this gene as a biomarker? | lung adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_02179","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Enterovirus A and Rhinovirus A both downregulate a specific gene. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 ... | |
medium_convergence_02180 | TRAF2 and TRAF3 both interact with a specific shared receptor protein. Experimental evidence indicates that this shared entity, along with TRAF5, interacts with the D2 subdomain of this receptor in vitro and in vivo. Which cellular component is this shared entity located in? | extracellular exosome | Medium | convergence | {"qa_id":"medium_convergence_02180","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"TRAF2 and TRAF3 both interact with a specific shared receptor protein. Experimental evidence indicates that this shared entity, along with TRAF5, interacts w... | |
medium_convergence_02181 | BABAM1 and ATM each interact with more than one shared protein. Evidence concerning one shared entity reports that ATM forms a stable complex with a histone acetyltransferase through the conserved FATC domain of ATM. Which protein is connected to that entity through encodes? | Histone acetyltransferase KAT5 | Medium | convergence | {"qa_id":"medium_convergence_02181","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"BABAM1 and ATM each interact with more than one shared protein. Evidence concerning one shared entity reports that ATM forms a stable complex with a histone ... | |
medium_convergence_02182 | Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839) shows a log2 fold change of -1.458 and an adjusted p-value of 0.002794. Which disease is associated with this gene as a biomarker? | intrahepatic cholangiocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_02182","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Zaire ebolavirus and Zika virus both downregulate a specific gene. Experimental data for this gene in a retinal pigment epithelium cell line (study GSE100839... | |
medium_convergence_02183 | CHUK and IKBKG both interact with a shared protein. Experimental evidence indicates that IKKalpha and IKKbeta were coimmunoprecipitated with this shared interaction partner in the absence of TAB1. Which protein, encoded by the gene corresponding to this shared interaction partner, is linked to this entity via the 'enco... | Mitogen-activated protein kinase kinase kinase 7 | Medium | convergence | {"qa_id":"medium_convergence_02183","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"CHUK and IKBKG both interact with a shared protein. Experimental evidence indicates that IKKalpha and IKKbeta were coimmunoprecipitated with this shared inte... | |
medium_convergence_02185 | HDAC1 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'An affinity-purified HDAC1 corepressor complex also contains this entity, suggesting that MeCP1 corresponds to a fraction of this complex.' Which protein is connected to that entity through the 'encodes' rela... | Methyl-CpG-binding domain protein 2 | Medium | convergence | {"qa_id":"medium_convergence_02185","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"HDAC1 and H3C1 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'An affinity-purified HDAC1 corepressor comple... | |
medium_convergence_02186 | NBN and NSD2 both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between MRN and the tandem breast cancer carboxy-terminal (BRCT) repeats in [the shared protein], and is accompanied by hyper-phosphorylation of both Nbs1 and [the shared pr... | TP53-binding protein 1 | Medium | convergence | {"qa_id":"medium_convergence_02186","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"NBN and NSD2 both interact with a shared protein. Evidence regarding this shared protein states: 'This effect is dependent on a direct interaction between MR... | |
medium_convergence_02190 | Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately 2.23 and an adjusted p-value of 0.00135. What molecular function is enabled by this gene? | prostaglandin E receptor activity | Medium | convergence | {"qa_id":"medium_convergence_02190","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"Both Human immunodeficiency virus 1 and Human mastadenovirus C are known to upregulate a specific shared gene. Experimental data for this gene in macrophages... | |
medium_convergence_02191 | GTF2H2 and PCNA share common binding partners. One such shared partner is associated with evidence stating that a specific protein was shown to be a novel PCNA-binding protein. Which protein is encoded by this shared partner? | DNA polymerase delta subunit 4 | Medium | convergence | {"qa_id":"medium_convergence_02191","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"GTF2H2 and PCNA share common binding partners. One such shared partner is associated with evidence stating that a specific protein was shown to be a novel PC... | |
medium_convergence_02192 | The trigeminal neural crest and the facio-acoustic neural crest share a common anatomical classification. Evidence indicates that the entity giving rise to the trigeminal ganglion belongs to this shared classification. What is the broader anatomical category connected to this shared classification via an 'is a' relatio... | embryonic tissue | Medium | convergence | {"qa_id":"medium_convergence_02192","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"The trigeminal neural crest and the facio-acoustic neural crest share a common anatomical classification. Evidence indicates that the entity giving rise to t... | |
medium_convergence_02193 | DCUN1D3 and CRY2 both interact with a specific protein. Evidence indicates that this protein functions within the SCF ubiquitin ligase complex to mediate the ubiquitination and degradation of Cry1 and Cry2. Which protein is encoded by the gene corresponding to this shared interaction partner? | F-box/LRR-repeat protein 3 | Medium | convergence | {"qa_id":"medium_convergence_02193","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"DCUN1D3 and CRY2 both interact with a specific protein. Evidence indicates that this protein functions within the SCF ubiquitin ligase complex to mediate the... | |
medium_convergence_02194 | ARNT and CUL2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We have previously shown that the C-terminal PAS domains of an HIF-alpha isoform (HIF-2alpha) and ARNT interact in vitro, and that mutations in the solvent-exposed beta-sheet surface of the HIF-2alpha domain n... | transcription regulator complex | Medium | convergence | {"qa_id":"medium_convergence_02194","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"ARNT and CUL2 each interact with more than one shared protein. Evidence concerning one shared entity reports: 'We have previously shown that the C-terminal P... | |
medium_convergence_02195 | PRKN and DDX27 share common interaction partners. One such shared partner is described in evidence stating: 'Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex.' Which protein is encoded by this specific shared interaction partner? | Ribosome biogenesis protein WDR12 | Medium | convergence | {"qa_id":"medium_convergence_02195","difficulty":"medium","subtype":"convergence","detailed_subtype":"raw_json_two_anchor_context","locator":"context","question":"PRKN and DDX27 share common interaction partners. One such shared partner is described in evidence stating: 'Applying a mass spectrometric analysis, we ident... |
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