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medium_hidden_intermediate_10944 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables serine-type endopeptidase inhibitor activity. Evidence for one such gene reports a log2 fold change of 1.327 and an adjusted p-value of 0.0166. Which biological process is that gene involved in? | regulation of acrosome reaction | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10944","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that enables serine-type endopeptidase inhibitor ac... | |
medium_hidden_intermediate_10945 | Human immunodeficiency virus 1 upregulates a gene that is associated with hyperplasia. Evidence for this gene in macrophages (study GSE108897) reports a log2 fold change of 1.274 and an adjusted p-value of 6.065e-05. Which protein is encoded by this gene? | Cell growth regulator with RING finger domain protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10945","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 upregulates a gene that is associated with hyperplasia. Evidence for this gene in macrophages... | |
medium_hidden_intermediate_10948 | Human alphaherpesvirus 3 upregulates a gene that participates in the antimicrobial mechanism of IFN-stimulated genes. Evidence for one such gene reports a log2 fold change of 3.504 and an adjusted p-value of 6.193e-11. Which protein is encoded by that gene? | Guanylate-binding protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10948","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in the antimicrobial mechanism of IFN-stimulated genes. Eviden... | |
medium_hidden_intermediate_10950 | Human betaherpesvirus 5 is associated with the downregulation of a gene that serves as a biomarker for colorectal carcinoma. In a study of foreskin fibroblast cell lines (GSE132081), this gene exhibited a log2 fold change of approximately -1.21 and an adjusted p-value of 0.0061. Which protein is encoded by this gene? | CDK5 and ABL1 enzyme substrate 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10950","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human betaherpesvirus 5 is associated with the downregulation of a gene that serves as a biomarker for colorectal carcinoma.... | |
medium_hidden_intermediate_10951 | CPAP is known to bind to a specific protein that enables protein binding. A study provides evidence stating: 'we show that Rab11 can simultaneously bind FIP3 and a Rab11-interacting protein.' This evidence pertains to one of the proteins connected to CPAP. Which protein is encoded by the gene corresponding to this enti... | Rab-3A-interacting protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10951","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"CPAP is known to bind to a specific protein that enables protein binding. A study provides evidence stating: 'we show that R... | |
medium_hidden_intermediate_10952 | Zika virus downregulates a gene that participates in Ub-specific processing proteases. In a study of glioma stem cells (GSE114907), one such gene showed a log2 fold change of -1.093 and an adjusted p-value of 0.02866. Which protein is encoded by this gene? | 26S proteasome non-ATPase regulatory subunit 11 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10952","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that participates in Ub-specific processing proteases. In a study of glioma stem cells (GSE1... | |
medium_hidden_intermediate_10953 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with NFIA. One of these genes was reported in a study of colonic adenocarcinoma cell lines with a log2 fold change of approximately 1.254 and an adjusted p-value of 0.0309. Which protein is encoded by this specific gene? | High mobility group protein 20A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10953","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with NFIA. One of these gene... | |
medium_hidden_intermediate_10955 | TRIM28 interacts with a gene that is enriched in neutrophils. Evidence for this gene includes a mean expression of 19.00 TPM, a z-score of 3.58, and a fold enrichment of 19.98. Which molecular function is enabled by this gene? | transcription cis-regulatory region binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10955","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"TRIM28 interacts with a gene that is enriched in neutrophils. Evidence for this gene includes a mean expression of 19.00 TPM... | |
medium_hidden_intermediate_10957 | Human polyomavirus 1 upregulates a gene that enables protein binding. Evidence for this gene in renal epithelial cells (study GSE135833) reports a log2 fold change of approximately 1.40 and an adjusted p-value of approximately 0.020. Which cellular component is this gene located in? | nucleus | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10957","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that enables protein binding. Evidence for this gene in renal epithelial cells (stud... | |
medium_hidden_intermediate_10958 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the toxicity of botulinum toxin type A (botA) via a participation relationship. One of these genes exhibits a log2 fold change of 1.278 and an adjusted p-value of 0.001343 in a specific study. Which pro... | Synaptic vesicle glycoprotein 2C | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10958","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the to... | |
medium_hidden_intermediate_10960 | Zika virus downregulates a specific gene that participates in biological oxidations. Transcriptomic data from glioma stem cells (study GSE114907) indicates this gene has a log2 fold change of approximately -2.015 and an adjusted p-value of 0.01131. Which cellular component is this gene located in? | extracellular exosome | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10960","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that participates in biological oxidations. Transcriptomic data from glioma stem ce... | |
medium_hidden_intermediate_10961 | Zika virus is reported to downregulate a gene that serves as a biomarker for prostate cancer. In a specific study (GSE114907) involving glioma stem cells, one such gene exhibited a log2 fold change of -2.501 and an adjusted p-value of 0.01234. Which protein is encoded by this gene? | Testis-specific Y-encoded-like protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10961","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus is reported to downregulate a gene that serves as a biomarker for prostate cancer. In a specific study (GSE114907... | |
medium_hidden_intermediate_10963 | Two genes are downregulated by Pegivirus C and both interact with YWHAZ. One of these genes exhibits a log2 fold change of -1.789 and an adjusted p-value of 0.007725 in peripheral blood mononuclear cells. Which disease is associated with this specific gene? | B-cell chronic lymphocytic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10963","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Pegivirus C and both interact with YWHAZ. One of these genes exhibits a log2 fold change of -... | |
medium_hidden_intermediate_10965 | Zika virus downregulates a gene that interacts with LATS1. Experimental data for this gene in glioma stem cells (study GSE114907) shows a log2 fold change of -1.597 and an adjusted p-value of 0.01445. Which protein is encoded by this gene? | Tyrosine-protein phosphatase non-receptor type 13 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10965","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with LATS1. Experimental data for this gene in glioma stem cells (study GSE11... | |
medium_hidden_intermediate_10966 | Two genes are linked to Measles morbillivirus via upregulation and to essential thrombocythemia via association. One of these genes has a reported log2 fold change of 1.261 and an adjusted p-value of 0.001189. Which protein is encoded by this specific gene? | HMG domain-containing protein 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10966","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Measles morbillivirus via upregulation and to essential thrombocythemia via association. One of thes... | |
medium_hidden_intermediate_10967 | A gene is upregulated by Measles morbillivirus and participates in chromatin organization. Experimental data for this gene shows a log2 fold change of 1.091 and an adjusted p-value of 0.0002255. Which disease is associated with this gene as a biomarker? | childhood kidney Wilms tumor | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10967","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in chromatin organization. Experimental data for this gene s... | |
medium_hidden_intermediate_10968 | In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a specific gene that participates in the Cell Cycle. This gene exhibited a log2 fold change of approximately 1.063 and an adjusted p-value of 0.0001089. Which gene interacts with this upregulated entity? | TARS2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10968","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of pleural mesothelioma cells (GSE117668), Measles morbillivirus was found to upregulate a specific gene that par... | |
medium_hidden_intermediate_10969 | In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and interacts with TRAF6. This gene exhibits a log2 fold change of -2.418 and an adjusted p-value of 0.006381. Which protein is encoded by this gene? | Legumain | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10969","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and interacts with TRAF6. T... | |
medium_hidden_intermediate_10972 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables ubiquitin-like protein transferase activity. Evidence for one such gene reports a log2 fold change of -1.013 and an adjusted p-value of 0.03375. Which protein is encoded by that gene? | E3 ubiquitin-protein ligase RNF139 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10972","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that enables ubiquitin-like protein transferase a... | |
medium_hidden_intermediate_10974 | A gene serves as a marker for Myeloid conventional dendritic cells and is localized to the lysosome. Evidence regarding this gene states: 'The two proteins are highly expressed in CTLs and mast cells where they colocalize on secretory lysosomes.' Which disease is associated with genomic alterations in this gene? | Griscelli syndrome type 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10974","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene serves as a marker for Myeloid conventional dendritic cells and is localized to the lysosome. Evidence regarding this... | |
medium_hidden_intermediate_10976 | Zika virus downregulates a specific gene product that is located in the autophagosome membrane. In a study of glioma stem cells (GSE114907), this entity exhibited a log2 fold change of approximately -1.92 and an adjusted p-value of 0.016. Which protein is encoded by this gene? | Synaptosomal-associated protein 47 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10976","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene product that is located in the autophagosome membrane. In a study of glioma stem ce... | |
medium_hidden_intermediate_10977 | Zaire ebolavirus upregulates a gene that participates in the Innate Immune System. In a study of retinal pigment epithelium cells (GSE100839), this gene showed a log2 fold change of approximately 1.143 and an adjusted p-value of 0.01901. Which gene interacts with this upregulated gene? | H2AC25 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10977","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a gene that participates in the Innate Immune System. In a study of retinal pigment epithelium ... | |
medium_hidden_intermediate_10978 | A gene is downregulated by Vaccinia virus and is involved in the epigenetic regulation of gene expression. Transcriptomic data for this gene in a cervical adenocarcinoma cell line (study GSE11238) reports a log2 fold change of -1.664 and an adjusted p-value of 0.007058. Which cellular component is this gene located in? | Cul4-RING E3 ubiquitin ligase complex | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10978","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Vaccinia virus and is involved in the epigenetic regulation of gene expression. Transcriptomic da... | |
medium_hidden_intermediate_10979 | Measles morbillivirus downregulates a gene that is located in the plasma membrane. Evidence for one such gene reports a log2 fold change of -1.207 and an adjusted p-value of 0.001873. Which biological process is this gene involved in? | leukocyte tethering or rolling | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10979","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus downregulates a gene that is located in the plasma membrane. Evidence for one such gene reports a log2... | |
medium_hidden_intermediate_10980 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to TAF9B via a binding relationship. One of these genes exhibits a log2 fold change of 1.175 and an adjusted p-value of 0.000268 in a specific study. Which disease is associated with this spec... | small cell lung carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10980","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship ... | |
medium_hidden_intermediate_10981 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes involved in the fatty acid biosynthetic process. One such gene exhibited a log2 fold change of 2.083 and an adjusted p-value of 8.89e-07. Which protein interacts with this specific upregulated ge... | MRPS16 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10981","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate multiple genes... | |
medium_hidden_intermediate_10982 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Sphingolipid de novo biosynthesis. One of these genes has a reported log2 fold change of 1.221 and an adjusted p-value of 0.0295. Which protein is encoded by this specific gene? | Protein phosphatase 1L | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10982","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and participate in Sphingolipid de novo b... | |
medium_hidden_intermediate_10983 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and bind to COMMD1. One of these genes exhibits a log2 fold change of 1.304 and an adjusted p-value of 0.002691 in a specific study. Which protein is encoded by this gene? | Ankyrin repeat domain-containing protein 9 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10983","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and bind to COMMD1. One of these genes ex... | |
medium_hidden_intermediate_10986 | A gene is downregulated by Enterovirus A and participates in axon guidance. Experimental data for this gene in rhabdomyosarcoma cells (study GSE103308) reports a log2 fold change of approximately -1.64 and an adjusted p-value of 0.0012. Which disease is associated with this gene through genomic alterations? | childhood acute lymphoblastic leukemia | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10986","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Enterovirus A and participates in axon guidance. Experimental data for this gene in rhabdomyosarc... | |
medium_hidden_intermediate_10987 | A gene is upregulated by Measles morbillivirus and participates in HCMV Early Events. Evidence for this gene reports a log2 fold change of approximately 3.03 and an adjusted p-value of approximately 0.005. Which cell type is this gene enriched in? | naive B cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10987","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Measles morbillivirus and participates in HCMV Early Events. Evidence for this gene reports a log2 ... | |
medium_hidden_intermediate_10990 | Pegivirus C is reported to downregulate a gene that is located in the centrosome. Experimental data for this gene in peripheral blood mononuclear cells (study GSE131504) show a log2 fold change of approximately -1.87 and an adjusted p-value of 0.001372. Which disease is associated with this gene? | breast carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10990","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the centrosome. Experimental data for this gene in periphe... | |
medium_hidden_intermediate_10991 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BRCA1. One of these genes was reported in a study of non-small cell lung adenocarcinoma cell lines (GSE147507) with a log2 fold change of approximately 1.435 and an adjusted p-value of 4.801e-05. Which protein is encode... | XIAP-associated factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10991","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with BRCA1. One of these gen... | |
medium_hidden_intermediate_10994 | Human alphaherpesvirus 1 upregulates a gene that subsequently binds to NFATC2. In a study of monocytic leukemia cell lines (GSE114966), one such gene was found to have a log2 fold change of 2.356 and an adjusted p-value of 0.02937. Which protein is encoded by this specific gene? | Protein c-Fos | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10994","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 1 upregulates a gene that subsequently binds to NFATC2. In a study of monocytic leukemia cell lines (... | |
medium_hidden_intermediate_10996 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of the canonical Wnt signaling pathway. Evidence for one such gene reports a log2 fold change of -2.370 and an adjusted p-value of 8.372e-05. Which protein is encoded by that gene? | Notch-regulated ankyrin repeat-containing protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10996","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in the positive regulation of th... | |
medium_hidden_intermediate_10997 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables histone H2AXY142 phosphatase activity. Experimental data for this gene in lung cells (study GSE155241) show a log2 fold change of approximately 3.10 and an adjusted p-value of 0.0022. Which disease is associated with this gene? | adenoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10997","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and enables histone H2AXY142 phosphatase acti... | |
medium_hidden_intermediate_10998 | Zika virus downregulates a specific gene that enables transcription cis-regulatory region binding. In a study of glioma stem cells (GSE114907), this gene exhibited a log2 fold change of -2.141 and an adjusted p-value of 0.04591. Which disease is associated with this gene as a biomarker? | colon carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10998","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a specific gene that enables transcription cis-regulatory region binding. In a study of glioma stem... | |
medium_hidden_intermediate_10999 | Measles morbillivirus upregulates a gene that is involved in the negative regulation of the apoptotic process. Evidence for one such gene reports a log2 fold change of 5.480 and an adjusted p-value of 0.01518. Which disease is associated with that gene? | anencephaly 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_10999","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that is involved in the negative regulation of the apoptotic process. Evidence for ... | |
medium_hidden_intermediate_11001 | Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and onward to neuroblastoma via a biomarker relationship. One of these genes is associated with experimental data reporting a log2 fold change of approximately -3.286 and an adjusted p-value of... | Insulin gene enhancer protein ISL-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11001","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Severe acute respiratory syndrome-related coronavirus via a downregulation relationsh... | |
medium_hidden_intermediate_11002 | Zaire ebolavirus upregulates a specific gene that is enriched in plasmacytoid dendritic cells. Evidence for this gene reports a log2 fold change of 1.108 and an adjusted p-value of 2.831e-07. Which cellular component is this gene located in? | mitochondrion | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11002","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zaire ebolavirus upregulates a specific gene that is enriched in plasmacytoid dendritic cells. Evidence for this gene report... | |
medium_hidden_intermediate_11004 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in 3'-UTR-mediated mRNA destabilization. Evidence for this specific gene reports a log2 fold change of -1.215 and an adjusted p-value of 0.001582. Which protein is encoded by this gene? | E3 ubiquitin-protein ligase TRIM71 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11004","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that is involved in 3'-UTR-mediated mRNA destabil... | |
medium_hidden_intermediate_11005 | Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the proteasome-mediated ubiquitin-dependent protein catabolic process. One of these genes exhibits a log2 fold change of -2.518 and an adjusted p-value of 0.04072. Which cellular component is the location of this sp... | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11005","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are downregulated by Severe acute respiratory syndrome-related coronavirus and are involved in the proteasome-medi... | |
medium_hidden_intermediate_11006 | In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is downregulated by the virus and participates in the 'Phase I - Functionalization of compounds' pathway. This gene exhibits a log2 fold change of approximately -1.97 and an adjusted p-value of 0.00... | Mitochondrial amidoxime-reducing component 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11006","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of lung cells infected with Severe acute respiratory syndrome-related coronavirus (GSE148697), a specific gene is... | |
medium_hidden_intermediate_11009 | Hepacivirus C infection is associated with the upregulation of genes involved in nicotinate metabolism. One such gene exhibits a log2 fold change of 4.747 and an adjusted p-value of 0.02119 in hepatocytes. Which protein is encoded by this specific gene? | Nicotinate phosphoribosyltransferase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11009","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C infection is associated with the upregulation of genes involved in nicotinate metabolism. One such gene exhibi... | |
medium_hidden_intermediate_11013 | Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the RHO GTPase cycle. Evidence for one such gene reports a log2 fold change of -1.535 and an adjusted p-value of 0.0004172. Which biological process is this gene involved in? | positive regulation of cell migration | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11013","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus downregulates a gene that participates in the RHO GTPase cycle. Eviden... | |
medium_hidden_intermediate_11015 | In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and interacts with RHOA. This gene exhibits a log2 fold change of -1.909 and an adjusted p-value of 0.00356. Which protein is encoded by this gene? | InaD-like protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11015","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is downregulated by Human immunodeficiency virus 1 and interacts with RHOA. Th... | |
medium_hidden_intermediate_11016 | Pegivirus C is reported to downregulate a gene that is located in the extracellular region. Evidence for one such gene shows a log2 fold change of -1.335 and an adjusted p-value of 0.0009008. Which disease is associated with this gene as a biomarker? | seminoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11016","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in the extracellular region. Evidence for one such gene shows... | |
medium_hidden_intermediate_11018 | Cardiovirus A upregulates a gene that enables peptidoglycan immune receptor activity. In a study of cervical adenocarcinoma cell lines (GSE122967), one such gene showed a log2 fold change of 1.231 and an adjusted p-value of 0.03476. Which protein is encoded by this gene? | Peptidoglycan recognition protein 4 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11018","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that enables peptidoglycan immune receptor activity. In a study of cervical adenocarcinoma ... | |
medium_hidden_intermediate_11020 | Human polyomavirus 1 upregulates a gene that is located in the sperm flagellum. Evidence for one such gene reports a log2 fold change of 5.191 and an adjusted p-value of 0.03263. Which protein is encoded by that gene? | Cytochrome b5 domain-containing protein 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11020","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human polyomavirus 1 upregulates a gene that is located in the sperm flagellum. Evidence for one such gene reports a log2 fo... | |
medium_hidden_intermediate_11021 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with ELOC. Experimental data for this gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.97 and an adjusted p-value of 0.000148. Which protein is encoded by this gene? | Amyloid protein-binding protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11021","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with ELOC. Experimental data for this gene ... | |
medium_hidden_intermediate_11022 | In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Cytokine Signaling in the Immune system. This specific gene exhibits a log2 fold change of 3.107 and an adjusted p-value of 0.0103. Which cellular component is this gene located in? | cytoplasm | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11022","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is upregulated by Human immunodeficiency virus 1 and participates in Cytokine ... | |
medium_hidden_intermediate_11024 | Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to GOLPH3 via an 'interacts with' relationship. One of these genes is associated with a log2 fold change of approximately -1.017 and an adjusted p-value of 0.03175. Which cell type is this specific gene enriched i... | eosinophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11024","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Human immunodeficiency virus 1 via a 'downregulates' relationship and to GOLPH3 via an ... | |
medium_hidden_intermediate_11025 | Human immunodeficiency virus 1 downregulates a gene that is located in the kinetochore. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.283 and an adjusted p-value of 0.001369. Which protein is encoded by this gene? | Microtubule cross-linking factor 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11025","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is located in the kinetochore. In a study of macrophages (GSE108897... | |
medium_hidden_intermediate_11026 | Pegivirus C is reported to downregulate a specific gene, which in turn interacts with COMMD8. Experimental data for this intermediate gene in peripheral blood mononuclear cells (from study GSE131504) shows a log2 fold change of approximately -1.122 and an adjusted p-value of 0.02043. Which protein is encoded by this in... | COMM domain-containing protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11026","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a specific gene, which in turn interacts with COMMD8. Experimental data for this int... | |
medium_hidden_intermediate_11028 | A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with KIAA0753. Experimental data for this gene reports a log2 fold change of approximately 1.806 and an adjusted p-value of 0.01008. In which cell type is this gene enriched? | plasmacytoid dendritic cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11028","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Severe acute respiratory syndrome-related coronavirus and interacts with KIAA0753. Experimental dat... | |
medium_hidden_intermediate_11030 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involved in nucleobase-containing compound metabolic process. One such gene exhibited a log2 fold change of 1.562 and an adjusted p-value of 0.02943. Which protein is encoded by this specific gene? | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11030","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene involve... | |
medium_hidden_intermediate_11031 | Hepacivirus C is reported to upregulate a gene that is associated with neuroblastoma. One such gene exhibits a log2 fold change of 1.083 and an adjusted p-value of 3.357e-07 in liver cells. Which protein is encoded by this specific gene? | NBPF family member NBPF10 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11031","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that is associated with neuroblastoma. One such gene exhibits a log2 fold cha... | |
medium_hidden_intermediate_11032 | Human alphaherpesvirus 3 upregulates a gene that participates in Cytokine Signaling in the Immune system. Evidence for this specific gene reports a log2 fold change of 3.571 and an adjusted p-value of 3.23e-13. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11032","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human alphaherpesvirus 3 upregulates a gene that participates in Cytokine Signaling in the Immune system. Evidence for this ... | |
medium_hidden_intermediate_11034 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell-cell signaling. Evidence for one such gene reports a log2 fold change of 2.886 and an adjusted p-value of 0.0008942. Which protein is encoded by that gene? | C-C motif chemokine 17 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11034","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in cell-cell signaling. Evidence f... | |
medium_hidden_intermediate_11036 | In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in SRP-dependent cotranslational protein targeting to the membrane. This gene exhibits a log2 fold change of approximately 1.154 and an adjusted p-value of 0.001322. Which biological process is this... | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11036","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cells infected with Vaccinia virus, a specific gene is upregulated and participates in... | |
medium_hidden_intermediate_11038 | In a study of Influenza A virus infection, two genes are identified as being upregulated by the virus and enriched in eosinophils. One of these genes exhibits a log2 fold change of approximately 1.008 and an adjusted p-value of 4.578e-07. What molecular function is enabled by this specific gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11038","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, two genes are identified as being upregulated by the virus and enriched in eosino... | |
medium_hidden_intermediate_11041 | In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and serving as a biomarker for breast cancer. This specific gene exhibits a log2 fold change of approximately -5.66 and an adjusted p-value of 0.01647. Which protein is encoded by this gene? | Myelin and lymphocyte protein | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11041","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), a gene is identified as being downregulated by Human immunodeficiency virus 1 and ser... | |
medium_hidden_intermediate_11043 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the process of Degradation of CRY and PER proteins via a participation relationship. One of these genes is associated with a log2 fold change of 1.236 and an adjusted p-value of 0.002074. Which protein ... | Cryptochrome-2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11043","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via an upregulation relationship and to the pr... | |
medium_hidden_intermediate_11044 | A gene is downregulated by Measles morbillivirus and located in extracellular exosomes. Experimental evidence for this gene reports a log2 fold change of -1.027 and an adjusted p-value of 0.000276. Which biological process is this gene involved in? | quinone catabolic process | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11044","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Measles morbillivirus and located in extracellular exosomes. Experimental evidence for this gene ... | |
medium_hidden_intermediate_11045 | Zika virus infection leads to the downregulation of certain genes that are localized to focal adhesions. In a study of glioma stem cells (GSE114907), one such downregulated gene exhibited a log2 fold change of approximately -1.91 and an adjusted p-value of 0.016. Which protein is encoded by this specific gene? | Sodium/hydrogen exchanger 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11045","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus infection leads to the downregulation of certain genes that are localized to focal adhesions. In a study of gliom... | |
medium_hidden_intermediate_11046 | In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in the response to tumor necrosis factor. Experimental data for this gene reports a log2 fold change of 1.437 and an adjusted p-value of 7.955e-08. Which protein is encoded by this gene? | Mitogen-activated protein kinase kinase kinase kinase 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11046","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Influenza A virus infection, a specific gene is upregulated by the virus and is involved in the response to tu... | |
medium_hidden_intermediate_11047 | Pegivirus C is reported to downregulate a gene that is located in an organelle membrane contact site. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibits a log2 fold change of -1.110 and an adjusted p-value of 0.01498. Which protein is encoded by this specific gene? | Autophagy-related protein 2 homolog A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11047","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that is located in an organelle membrane contact site. In a study of peripher... | |
medium_hidden_intermediate_11048 | Cardiovirus A upregulates a gene that is associated with melanoma. Evidence for this gene in a cervical adenocarcinoma cell line (study GSE122967) reports a log2 fold change of 3.648 and an adjusted p-value of 0.04924. Which protein is encoded by this gene? | Defensin beta 4A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11048","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Cardiovirus A upregulates a gene that is associated with melanoma. Evidence for this gene in a cervical adenocarcinoma cell ... | |
medium_hidden_intermediate_11049 | Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is involved in the positive regulation of amyloid-beta formation. Experimental data for one such gene indicates a log2 fold change of -1.050 and an adjusted p-value of 0.00876. Which protein is encoded by this specific gene? | Proton myo-inositol cotransporter | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11049","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus is reported to downregulate a gene that is involved in the positive re... | |
medium_hidden_intermediate_11050 | Rift Valley fever phlebovirus upregulates a gene that participates in the Immune System. In a study using SAEC cells (GSE102481), one such gene showed a log2 fold change of 2.238 and an adjusted p-value of 0.005848. Which protein is encoded by this gene? | ATP-dependent RNA helicase DHX58 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11050","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Rift Valley fever phlebovirus upregulates a gene that participates in the Immune System. In a study using SAEC cells (GSE102... | |
medium_hidden_intermediate_11051 | Enterovirus A is reported to upregulate a gene that is enriched in intermediate monocytes. Evidence for this specific gene in rhabdomyosarcoma cells (study GSE103308) indicates a log2 fold change of approximately 2.80 and an adjusted p-value of 0.04015. Which protein is encoded by this gene? | FERM domain containing 3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11051","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Enterovirus A is reported to upregulate a gene that is enriched in intermediate monocytes. Evidence for this specific gene i... | |
medium_hidden_intermediate_11053 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to MAPT via interaction. One of these genes exhibits a log2 fold change of -1.261 and an adjusted p-value of 0.0003906 in lung tissue. Which disease is associated with this specific gene as a biomarker? | adult T-cell leukemia/lymphoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11053","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via downregulation and to MAPT vi... | |
medium_hidden_intermediate_11056 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the cell surface receptor signaling pathway. Evidence for this gene reports a log2 fold change of -1.085 and an adjusted p-value of 0.01129. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11056","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in the cell surface recepto... | |
medium_hidden_intermediate_11057 | Two genes are structurally linked from Human immunodeficiency virus 1 via an upregulation relationship and onward to blast phase chronic myelogenous leukemia, BCR-ABL1 positive via an association relationship. One of these genes is reported in a study (GSE108897) on macrophages with a log2 fold change of 2.652 and an a... | cyclooxygenase pathway | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11057","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked from Human immunodeficiency virus 1 via an upregulation relationship and onward to blast p... | |
medium_hidden_intermediate_11059 | Measles morbillivirus upregulates a gene that enables small GTPase binding. Evidence for this gene in study GSE131840 reports a log2 fold change of 1.052 and an adjusted p-value of 0.01266. Which cell type is this gene enriched in? | non-classical monocyte | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11059","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Measles morbillivirus upregulates a gene that enables small GTPase binding. Evidence for this gene in study GSE131840 report... | |
medium_hidden_intermediate_11060 | Zika virus downregulates a gene that interacts with UBE3A. In a study of glioma stem cells (GSE114907), one such gene exhibited a log2 fold change of -1.687 and an adjusted p-value of 0.01134. Which protein is encoded by this gene? | Max-binding protein MNT | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11060","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Zika virus downregulates a gene that interacts with UBE3A. In a study of glioma stem cells (GSE114907), one such gene exhibi... | |
medium_hidden_intermediate_11061 | Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationship and to Transcriptional Regulation by TP53 via a 'participates in' relationship. One of these genes is associated with experimental data showing a log2 fold change of approximately -1.085 and an ... | Sestrin-1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11061","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are structurally linked to Severe acute respiratory syndrome-related coronavirus via a 'downregulates' relationshi... | |
medium_hidden_intermediate_11062 | Human immunodeficiency virus 1 downregulates a gene that is involved in signal transduction. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of -1.417 and an adjusted p-value of 0.005906. Which gene does this entity bind to? | XPO1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11062","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in signal transduction. In a study of macrophages (GSE1... | |
medium_hidden_intermediate_11065 | A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in actin cytoskeleton organization. Transcriptomic data for this gene shows a log2 fold change of -5.036 and an adjusted p-value of 0.01688. Which disease is associated with this gene through genomic alterations? | gastrointestinal mucositis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11065","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is downregulated by Severe acute respiratory syndrome-related coronavirus and is involved in actin cytoskeleton organ... | |
medium_hidden_intermediate_11066 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in nervous system development. One of these genes exhibits a log2 fold change of 2.680 and an adjusted p-value of 0.007746 in a specific study. Which disease is associated with this specific gene? | nephrotic syndrome, type 21 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11066","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and are involved in nervous system develo... | |
medium_hidden_intermediate_11067 | Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to leukemia via an association relationship. One of these genes was reported in a study (GSE157852) involving choroid plexus epithelium cells, showing a log2 fold change of -1.453 and an adjusted p-value ... | Nurim | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11067","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are linked to Severe acute respiratory syndrome-related coronavirus via a downregulation relationship and to leuke... | |
medium_hidden_intermediate_11069 | Two genes are upregulated by Human immunodeficiency virus 1 and participate in GPCR ligand binding. One of these genes exhibits a log2 fold change of approximately 1.066 and an adjusted p-value of 0.0001438 in macrophages (study GSE108897). Which disease is associated with this specific gene? | carcinoma | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11069","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Human immunodeficiency virus 1 and participate in GPCR ligand binding. One of these genes exhib... | |
medium_hidden_intermediate_11070 | Two genes are identified as markers on Natural killer T cells and are both localized to the basolateral plasma membrane. One of these genes is specifically noted in the kidney, where it is predominantly found along the basolateral membrane of distal tubular segments involved in magnesium ion reabsorption. Which biologi... | magnesium ion homeostasis | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11070","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are identified as markers on Natural killer T cells and are both localized to the basolateral plasma membrane. One... | |
medium_hidden_intermediate_11073 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein serine/threonine kinase activity. One of these genes shows a log2 fold change of 1.193 and an adjusted p-value of 0.007923 in a specific study. Which cell type is this gene enriched in? | neutrophil | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11073","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and both enable protein serine/threonine ... | |
medium_hidden_intermediate_11075 | In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with HSPA5. One such gene exhibits a log2 fold change of 1.383 and an adjusted p-value of 7.904e-05. Which protein is encoded by this specific gene? | Mitochondrial cardiolipin hydrolase | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11075","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of macrophages (GSE108897), Human immunodeficiency virus 1 upregulates a gene that subsequently interacts with HS... | |
medium_hidden_intermediate_11076 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of chromatin organization. Evidence for this specific gene reports a log2 fold change of 10.472 and an adjusted p-value of 0.005345. Which protein is encoded by this gene? | Methyl-CpG-binding domain protein 3-like 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11076","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that is involved in the regulation of chromatin org... | |
medium_hidden_intermediate_11077 | In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and interacting with DYNLL1. One of these genes exhibits a log2 fold change of 3.222 and an adjusted p-value of 0.02637. Which protein is encoded by this specific gene? | Angiomotin-like protein 2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11077","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, two genes are identified as being upregulated by the virus and interacting wi... | |
medium_hidden_intermediate_11078 | Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of histamine secretion by mast cells. Evidence for this gene in macrophages (from study GSE108897) reports a log2 fold change of approximately -5.04 and an adjusted p-value of approximately 0.036. Which protein is encoded by... | Group 3 secretory phospholipase A2 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11078","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that is involved in the positive regulation of histamine secretion by ma... | |
medium_hidden_intermediate_11080 | Pegivirus C is reported to downregulate a gene that enables mitogen-activated protein kinase binding. In a study of peripheral blood mononuclear cells (GSE131504), one such gene exhibited a log2 fold change of approximately -1.76 and an adjusted p-value of 0.0172. Which protein is encoded by this specific gene? | Cyclic AMP-dependent transcription factor ATF-7 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11080","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Pegivirus C is reported to downregulate a gene that enables mitogen-activated protein kinase binding. In a study of peripher... | |
medium_hidden_intermediate_11081 | A specific protein entity is known to interact with Ring-box protein 1 (RBX1). Mechanistic evidence indicates that platinum treatment impairs the complex formation required for the proteasome-mediated degradation of this entity, resulting in its accumulation due to a weakened association with RBX1. This entity is also ... | natural killer cell | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11081","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A specific protein entity is known to interact with Ring-box protein 1 (RBX1). Mechanistic evidence indicates that platinum ... | |
medium_hidden_intermediate_11082 | Human immunodeficiency virus 1 downregulates a gene that participates in RNA metabolism. In a study of macrophages (GSE108897), this gene exhibited a log2 fold change of approximately -1.008 and an adjusted p-value of 0.03536. Which protein is encoded by this gene? | rRNA methyltransferase 2, mitochondrial | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11082","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Human immunodeficiency virus 1 downregulates a gene that participates in RNA metabolism. In a study of macrophages (GSE10889... | |
medium_hidden_intermediate_11083 | A gene is upregulated by Human gammaherpesvirus 8 and is enriched in basophils. Experimental data for this gene reports a log2 fold change of 1.312 and an adjusted p-value of 0.04969. Which molecular function is enabled by this gene? | protein binding | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11083","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"A gene is upregulated by Human gammaherpesvirus 8 and is enriched in basophils. Experimental data for this gene reports a lo... | |
medium_hidden_intermediate_11087 | Hepacivirus C upregulates multiple genes that participate in Nuclear Events (kinase and transcription factor activation). One such gene exhibits a log2 fold change of 2.852 and an adjusted p-value of 5.242e-06 in hepatocytes. Which protein is encoded by this specific gene? | DNA-binding protein inhibitor ID-3 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11087","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates multiple genes that participate in Nuclear Events (kinase and transcription factor activation). On... | |
medium_hidden_intermediate_11088 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that enables GTPase activator activity. One such gene exhibited a log2 fold change of 4.797 and an adjusted p-value of 8.948e-12. Which protein is encoded by this specific gene? | Rho GTPase-activating protein 11A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11088","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to upregulate a gene that en... | |
medium_hidden_intermediate_11089 | Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SNAI1. One of these genes was reported in a study on colonic adenocarcinoma cell lines with a log2 fold change of approximately 1.254 and an adjusted p-value of 0.0309. Which protein is encoded by this specific gene? | High mobility group protein 20A | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11089","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Two genes are upregulated by Severe acute respiratory syndrome-related coronavirus and interact with SNAI1. One of these gen... | |
medium_hidden_intermediate_11090 | Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in tRNA processing in the nucleus. Evidence for this gene reports a log2 fold change of 1.109 and an adjusted p-value of 0.03944. Which protein is encoded by this gene? | Ribonuclease P protein subunit p20 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11090","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Severe acute respiratory syndrome-related coronavirus upregulates a gene that participates in tRNA processing in the nucleus... | |
medium_hidden_intermediate_11091 | In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and participates in Sensory Perception. This specific gene exhibits a log2 fold change of approximately -1.54 and an adjusted p-value of approximately 0.026. Which protein is encoded by this gene? | Methionine aminopeptidase 1 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11091","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of peripheral blood mononuclear cells (GSE131504), a gene is identified that is downregulated by Pegivirus C and ... | |
medium_hidden_intermediate_11092 | Hepacivirus C is reported to upregulate a gene that subsequently interacts with REEP5. Experimental data for one such intermediate gene indicates a log2 fold change of approximately 1.01 and an adjusted p-value of 5.64e-05. Which protein is encoded by this specific gene? | Vesicle transport protein GOT1B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11092","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C is reported to upregulate a gene that subsequently interacts with REEP5. Experimental data for one such interm... | |
medium_hidden_intermediate_11093 | Hepacivirus C upregulates a gene that participates in the transport of small molecules. Evidence for one such gene reports a log2 fold change of 1.325 and an adjusted p-value of 0.007729. Which disease is connected to that gene through genomic alterations? | acquired polycythemia vera | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11093","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"Hepacivirus C upregulates a gene that participates in the transport of small molecules. Evidence for one such gene reports a... | |
medium_hidden_intermediate_11094 | In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain genes involved in nervous system development. One such gene exhibited a log2 fold change of approximately -1.45 and an adjusted p-value of 0.0287. Which protein is encoded by this specific gene? | Repulsive guidance molecule B | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11094","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of cervical adenocarcinoma cell lines (GSE11238), Vaccinia virus infection was found to downregulate certain gene... | |
medium_hidden_intermediate_11095 | In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product binds to RET. This gene exhibits a log2 fold change of 2.980 and an adjusted p-value of 0.03153. Which protein is encoded by this gene? | Docking protein 5 | Medium | hidden_intermediate | {"qa_id":"medium_hidden_intermediate_11095","difficulty":"medium","subtype":"hidden_intermediate","detailed_subtype":"upstream_downstream_context_joint","locator":"node_context_joint","question":"In a study of Measles morbillivirus infection, a specific gene is upregulated by the virus and its product binds to RET. Thi... |
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