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medium_convergence_00001 | BHLHE22 and RBCK1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a RING finger protein functioning as an E3 ligase for oxidized iron regulatory protein suggesting oxidation signals ubiquitination. For which disea... | alpha 1-antitrypsin deficiency | Medium | convergence | {"qa_id":"medium_convergence_00001","source_qa_id":"medium_convergence_two_branch_unequal_context_0316","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BHLHE22 and RBCK1 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00002 | CENPW and CCND1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes phosphorylated cyclin D1 recognition by a ubiquitin ligase where FBX4 and alphaB crystallin govern substrate specificity. For which disease is this protein reported as a biomarker? | malignant pleural mesothelioma | Medium | convergence | {"qa_id":"medium_convergence_00002","source_qa_id":"medium_convergence_two_branch_equal_context_0783","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CENPW and CCND1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00003 | AKAP8L, LMNA, and TOPBP1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the physical interaction between a nuclear matrix protein and a nuclear lamina protein with the binding site located at the carboxy terminus. Which disease is linked to genomic alterations i... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_00003","source_qa_id":"medium_convergence_three_branch_context_0672","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"AKAP8L, LMNA, and TOPBP1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00004 | BATF2 and CREBBP have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a binding interaction that prevents the phosphorylation of a transcription factor during cellular differentiation. Which disease is linked to genomi... | obesity disorder | Medium | convergence | {"qa_id":"medium_convergence_00004","source_qa_id":"medium_convergence_two_branch_unequal_context_0770","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BATF2 and CREBBP have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00005 | West Nile virus and Influenza A virus alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in bronchial epithelial cells with a log2 fold-change of about 1.35 and an adjusted p-value of about 0.00063. For which disease is this gene reported as a biomarker? | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00005","source_qa_id":"medium_convergence_two_branch_equal_context_1124","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Influenza A virus alter the expression of several genes in common. Express... | |
medium_convergence_00006 | KLF2, USP9X, and CTNNB1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a HECT-type ubiquitin ligase interacting with and targeting a transcription factor for poly-ubiquitination and proteasomal degradation in cells of a specific malignancy. For which disease is ... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_00006","source_qa_id":"medium_convergence_three_branch_context_0971","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"KLF2, USP9X, and CTNNB1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00007 | West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a melanoma cell line with a log2 fold-change of about 3.80 and an adjusted p-value of about 4.8e-13. For which disease is this gene reported as a biomarker? | squamous cell carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00007","source_qa_id":"medium_convergence_two_branch_equal_context_1092","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. ... | |
medium_convergence_00008 | CLEC1B and CFTR share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this protein's gen... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00008","source_qa_id":"medium_convergence_two_branch_equal_context_0703","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and CFTR share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00009 | HEYL and VHL have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how reducing the levels of a deubiquitinase decreases the interaction between a dishevelled protein and a von Hippel Lindau tumor suppressor. Which dise... | osteoarthritis, knee | Medium | convergence | {"qa_id":"medium_convergence_00009","source_qa_id":"medium_convergence_two_branch_unequal_context_0286","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"HEYL and VHL have overlapping extended protein-interaction neighborhoods containing severa... | |
medium_convergence_00010 | POU2F2 and KMT2D share more than one reported protein partner. Evidence concerning one of these shared proteins describes co-immunoprecipitation assays revealing that a histone methyltransferase associates with a steroid receptor in a ligand-independent manner in specific cells. Which disease has a therapeutic associat... | asthma | Medium | convergence | {"qa_id":"medium_convergence_00010","source_qa_id":"medium_convergence_two_branch_equal_context_0966","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"POU2F2 and KMT2D share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00011 | MUC12 and USP7 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes direct interaction between a deubiquitinase and a checkpoint ligand that serves to stabilize the ligand protein levels. Which disease has a causal ass... | enteritis | Medium | convergence | {"qa_id":"medium_convergence_00011","source_qa_id":"medium_convergence_two_branch_unequal_context_0063","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"MUC12 and USP7 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00012 | MME, CDK1, and ANLN share more than one reported protein partner. Evidence concerning one of these shared proteins describes the identification of a fifty-six kiloDalton phosphoprotein associated with a membrane metalloendopeptidase as a src-related kinase via immunoprecipitation. Which disease is linked to genomic alt... | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00012","source_qa_id":"medium_convergence_three_branch_context_0423","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"MME, CDK1, and ANLN share more than one reported protein partner. Evidence concerning one of these sha... | |
medium_convergence_00013 | MRPL53 and SP1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes an association between a kinase and a transcription factor that is strengthened by a histone deacetylase inhibitor treatment. Which disease has a causal association with this protein? | kidney cancer | Medium | convergence | {"qa_id":"medium_convergence_00013","source_qa_id":"medium_convergence_two_branch_equal_context_0153","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"MRPL53 and SP1 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00014 | GRIN2C and PTPN11 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the rapid recruitment of a phosphatase to a receptor leading to substrate dephosphorylation and complex dissociation upon ligand stimulation. Which... | cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00014","source_qa_id":"medium_convergence_two_branch_unequal_context_0380","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"GRIN2C and PTPN11 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00015 | INSRR, SOCS1, and EMD share more than one reported protein partner. Evidence concerning one of these shared proteins describes a strong physical interaction between a suppressor of cytokine signaling protein and an insulin-like growth factor receptor detected via yeast two-hybrid assay. Which disease has a therapeutic ... | prostate adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00015","source_qa_id":"medium_convergence_three_branch_context_0136","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"INSRR, SOCS1, and EMD share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00016 | FBXO18 and ATP6V1A share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical interaction between a DNA helicase and the major cellular single-stranded DNA binding protein complex. Which disease is associated with this protein? | leukemia | Medium | convergence | {"qa_id":"medium_convergence_00016","source_qa_id":"medium_convergence_two_branch_equal_context_0049","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"FBXO18 and ATP6V1A share more than one reported protein partner. Evidence concerning one of th... | |
medium_convergence_00017 | PLG and NR3C1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the detection of interactions between mitochondrial glucocorticoid receptor and pyruvate dehydrogenase and heat shock protein sixty. Which disease has a therapeutic association with this protein? | cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00017","source_qa_id":"medium_convergence_two_branch_equal_context_0680","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"PLG and NR3C1 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00018 | EPS8L1 and ABL1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct binding of an SH3 domain to a proline-rich site within the C-terminal region of Arg. Which disease is associated with this protein? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_00018","source_qa_id":"medium_convergence_two_branch_equal_context_0317","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"EPS8L1 and ABL1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00019 | IGFBP3 and SART1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the formation of complexes between an RNA binding protein and its dimerization partner with an insulin like growth factor binding protein. For which disease is this protein reported as a biomarker? | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00019","source_qa_id":"medium_convergence_two_branch_equal_context_0094","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IGFBP3 and SART1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00020 | ZNF366 and TP73 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes phosphorylation abrogating transactivation function and causing cytoplasmic sequestration in a complex with a chaperone protein. Which disease is lin... | even-plus syndrome | Medium | convergence | {"qa_id":"medium_convergence_00020","source_qa_id":"medium_convergence_two_branch_unequal_context_0973","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"ZNF366 and TP73 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00021 | CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one of these shared proteins describes a conserved tyrosine residue in a cdk binding domain being phosphorylated by a src family kinase and an oncogene product. Which disease is linked to genomic alterations in this protein's gene? | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00021","source_qa_id":"medium_convergence_two_branch_equal_context_0411","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00022 | Human gammaherpesvirus 4 and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in a monocytic leukemia cell line with a log2 fold-change of about -1.02 and an adjusted p-value of about 0.0037. For which disease is this gene rep... | depressive disorder | Medium | convergence | {"qa_id":"medium_convergence_00022","source_qa_id":"medium_convergence_two_branch_equal_context_1169","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human gammaherpesvirus 4 and Human alphaherpesvirus 1 alter the expression of several genes in... | |
medium_convergence_00023 | CLEC1B and ESR1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this protein's gen... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00023","source_qa_id":"medium_convergence_two_branch_equal_context_0704","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and ESR1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00024 | IGFBP3 and U2AF2 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a drug-induced complex formation between a DNA/RNA-binding protein and its dimerization partner with an insulin-like growth factor binding protein in basal-like breast cancer cells. For which diseas... | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00024","source_qa_id":"medium_convergence_two_branch_equal_context_0101","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IGFBP3 and U2AF2 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00025 | West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a melanoma cell line with a log2 fold-change of about 5.57 and an adjusted p-value of about 2.7e-16. For which disease is this gene reported as a biomarker? | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00025","source_qa_id":"medium_convergence_two_branch_equal_context_1088","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. ... | |
medium_convergence_00026 | ENAH and ABL1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct binding of an SH3 domain to a proline-rich site within the C-terminal region of Arg. Which disease is associated with this protein? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_00026","source_qa_id":"medium_convergence_two_branch_equal_context_0321","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"ENAH and ABL1 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00027 | CDH16 and SYVN1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes colocalization and physical interaction between an E3 ubiquitin ligase and amyloid precursor protein via a proline-rich domain. Which disease has a c... | aneuploidy | Medium | convergence | {"qa_id":"medium_convergence_00027","source_qa_id":"medium_convergence_two_branch_unequal_context_0249","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"CDH16 and SYVN1 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00028 | Human respirovirus 3 and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a monocytic leukemia cell line with a log2 fold-change of about 1.06 and an adjusted p-value of about 0.0074. For which disease is this gene reported a... | oral cavity cancer | Medium | convergence | {"qa_id":"medium_convergence_00028","source_qa_id":"medium_convergence_two_branch_equal_context_1245","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human respirovirus 3 and Human alphaherpesvirus 1 alter the expression of several genes in com... | |
medium_convergence_00029 | IGFBP3 and ERCC6 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the formation of complexes between an RNA binding protein and its dimerization partner with an insulin like growth factor binding protein. For which disease is this protein reported as a biomarker? | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00029","source_qa_id":"medium_convergence_two_branch_equal_context_0097","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IGFBP3 and ERCC6 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00030 | NRF1 and POLR2A share more than one reported protein partner. Evidence concerning one of these shared proteins describes the experimental confirmation of a molecular interaction using both immunoprecipitation and chromatin immunoprecipitation techniques to validate binding. Which disease is associated with this protein... | chondrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_00030","source_qa_id":"medium_convergence_two_branch_equal_context_0210","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NRF1 and POLR2A share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00031 | PIK3AP1 and KHDRBS1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a drug disrupting in vivo interactions between an RNA binding protein and other SH3 domain containing proteins. Which disease is linked to genomic alterations in this protein's gene? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00031","source_qa_id":"medium_convergence_two_branch_equal_context_0729","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"PIK3AP1 and KHDRBS1 share more than one reported protein partner. Evidence concerning one of t... | |
medium_convergence_00032 | CENPW and RNF7 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the differential interaction patterns of two ring finger proteins with various cullin family members and a specific related subunit. For which disease is this protein reported as a biomarker? | malignant pleural mesothelioma | Medium | convergence | {"qa_id":"medium_convergence_00032","source_qa_id":"medium_convergence_two_branch_equal_context_0781","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CENPW and RNF7 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00033 | LTB4R and MTOR have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the direct binding of an oncogenic GTPase to kinase complex components to promote enzymatic activity at the plasma membrane. Which disease has a thera... | renal fibrosis | Medium | convergence | {"qa_id":"medium_convergence_00033","source_qa_id":"medium_convergence_two_branch_unequal_context_0815","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"LTB4R and MTOR have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00034 | PDX1 and ATM share more than one reported protein partner. Evidence concerning one of these shared proteins describes an adaptor protein binding to a target to trigger ubiquitin attachment and subsequent degradation by the proteasome. For which disease is this protein reported as a biomarker? | clear cell renal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00034","source_qa_id":"medium_convergence_two_branch_equal_context_0957","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"PDX1 and ATM share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00035 | NPHP3 and KHDRBS1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the association of an RNA binding protein with specific structural domains of two distinct Src family kinases. Which disease is linked to genomic a... | type 1 diabetes mellitus 1 | Medium | convergence | {"qa_id":"medium_convergence_00035","source_qa_id":"medium_convergence_two_branch_unequal_context_0301","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"NPHP3 and KHDRBS1 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00036 | HOMER3 and ABL1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct binding of an SH3 domain to a proline-rich site within the C-terminal region of Arg. Which disease is associated with this protein? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_00036","source_qa_id":"medium_convergence_two_branch_equal_context_0320","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"HOMER3 and ABL1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00037 | Several genes responsive to Rhinovirus A exposure encode proteins within the extended interaction neighborhood of TGFB1I1. Expression data distinguish one of these genes: it was upregulated in cytotoxic T cells with a log2 fold-change of about 1.06 and an adjusted p-value of about 0.023. Which disease is associated wit... | B-cell chronic lymphocytic leukemia | Medium | convergence | {"qa_id":"medium_convergence_00037","source_qa_id":"medium_convergence_two_branch_unequal_context_1212","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Rhinovirus A exposure encode proteins within the extended inte... | |
medium_convergence_00038 | BATF2 and SMAD3 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes a microRNA binding to a ligase transcript while the ligase protein directly binds a signaling mediator. For which disease is this protein reported as... | lung cancer | Medium | convergence | {"qa_id":"medium_convergence_00038","source_qa_id":"medium_convergence_two_branch_unequal_context_0769","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"BATF2 and SMAD3 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00039 | IGFBP3 and HEXIM1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a drug-induced complex formation between a DNA/RNA-binding protein and its dimerization partner with an insulin-like growth factor binding protein in basal-like breast cancer cells. For which disea... | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00039","source_qa_id":"medium_convergence_two_branch_equal_context_0099","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IGFBP3 and HEXIM1 share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00040 | West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a foreskin fibroblast cell line with a log2 fold-change of about 1.26 and an adjusted p-value of about 0.00022. Which disease is associated with this gene? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_00040","source_qa_id":"medium_convergence_two_branch_equal_context_1107","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. E... | |
medium_convergence_00041 | POU2F2 and SMARCE1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct interactions made by a steroid receptor with specific chromatin remodeling complex subunits but not with other core subunits. Which disease has a therapeutic association with this protein? | asthma | Medium | convergence | {"qa_id":"medium_convergence_00041","source_qa_id":"medium_convergence_two_branch_equal_context_0968","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"POU2F2 and SMARCE1 share more than one reported protein partner. Evidence concerning one of th... | |
medium_convergence_00042 | IDH2 and CDC6 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the interaction between a cell cycle regulator and a cyclin protein through defined motifs that promote ubiquitylation and degradation of the regulator. Which disease is linked to genomic alterations i... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_00042","source_qa_id":"medium_convergence_two_branch_equal_context_0008","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IDH2 and CDC6 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00043 | CLEC1B and CDK9 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical association between a receptor for activated C kinase and the cytoplasmic tail of a C type lectin domain family member. Which disease is linked to genomic alterations in this protein's gen... | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00043","source_qa_id":"medium_convergence_two_branch_equal_context_0701","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and CDK9 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00044 | MPG and HDAC1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a physical interaction between a key regulator of eukaryotic gene expression and an adaptor protein involved in cellular events. Which disease is linked to genomic alterations in this protein's gene? | systemic lupus erythematosus | Medium | convergence | {"qa_id":"medium_convergence_00044","source_qa_id":"medium_convergence_two_branch_equal_context_1027","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"MPG and HDAC1 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00045 | Zaire ebolavirus and Human respirovirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a non-small cell lung adenocarcinoma cell line with a log2 fold-change of about 1.66 and an adjusted p-value of about 0.042. Which disease is associated with t... | testicular cancer | Medium | convergence | {"qa_id":"medium_convergence_00045","source_qa_id":"medium_convergence_two_branch_equal_context_1230","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Zaire ebolavirus and Human respirovirus 3 alter the expression of several genes in common. Exp... | |
medium_convergence_00046 | West Nile virus and Zaire ebolavirus alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a retinal pigment epithelium cell line with a log2 fold-change of about 6.06 and an adjusted p-value of about 0.00021. For which disease is this gene reported as a ... | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00046","source_qa_id":"medium_convergence_two_branch_equal_context_1114","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Zaire ebolavirus alter the expression of several genes in common. Expressi... | |
medium_convergence_00047 | SPIN1 and CSNK2A1 share more than one reported protein partner. Evidence concerning one of these shared proteins indicates that a ribosomal protein associates with the beta subunit of protein kinase CKII as reported in previous biochemical studies. Which disease is linked to genomic alterations in this protein's gene? | melanoma | Medium | convergence | {"qa_id":"medium_convergence_00047","source_qa_id":"medium_convergence_two_branch_equal_context_0185","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"SPIN1 and CSNK2A1 share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00048 | West Nile virus and Rhinovirus A alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in cytotoxic T cells with a log2 fold-change of about -1.32 and an adjusted p-value of about 8.6e-05. Which disease is associated with this gene? | acute myeloid leukemia | Medium | convergence | {"qa_id":"medium_convergence_00048","source_qa_id":"medium_convergence_two_branch_equal_context_1080","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Rhinovirus A alter the expression of several genes in common. Expression d... | |
medium_convergence_00049 | MRPL53 and RAF1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes an interaction between a kinase and a serine threonine kinase mediated by adaptor proteins in cellular and test tube settings. Which disease has a causal association with this protein? | kidney cancer | Medium | convergence | {"qa_id":"medium_convergence_00049","source_qa_id":"medium_convergence_two_branch_equal_context_0156","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"MRPL53 and RAF1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00050 | Human gammaherpesvirus 4 and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was downregulated in a monocytic leukemia cell line with a log2 fold-change of about -1.32 and an adjusted p-value of about 0.0018. Which disease is linked to genomic... | esophageal adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00050","source_qa_id":"medium_convergence_two_branch_equal_context_1170","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human gammaherpesvirus 4 and Human alphaherpesvirus 1 alter the expression of several genes in... | |
medium_convergence_00051 | AKAP8L, LMNA, and MYC share more than one reported protein partner. Evidence concerning one of these shared proteins describes a lamina binding partner exhibiting strong affinity for pocket C and weak affinity for pocket B within the nuclear structural framework. Which disease is linked to genomic alterations in this p... | familial dilated cardiomyopathy | Medium | convergence | {"qa_id":"medium_convergence_00051","source_qa_id":"medium_convergence_three_branch_context_0961","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"AKAP8L, LMNA, and MYC share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00052 | TP53INP1, NEK9, and RB1CC1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a molecular interaction mediated by a specific functional binding motif within the protein structure. For which disease is this protein reported as a biomarker? | hyperphosphatemia | Medium | convergence | {"qa_id":"medium_convergence_00052","source_qa_id":"medium_convergence_three_branch_context_0073","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"TP53INP1, NEK9, and RB1CC1 share more than one reported protein partner. Evidence concerning one of th... | |
medium_convergence_00053 | ADRBK2 and MAPK10 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how two beta arrestin isoforms associate with a kinase via its N-terminal domain lacking a common docking motif. Which disease is associated with t... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_00053","source_qa_id":"medium_convergence_two_branch_unequal_context_0944","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"ADRBK2 and MAPK10 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00054 | NUBP2 and HSPA1A share more than one reported protein partner. Evidence concerning one of these shared proteins describes the binding interaction between a chaperone co-chaperone and a heat shock protein in intact cells which increases upon short term chemical exposure. For which disease is this protein reported as a b... | pituitary gigantism | Medium | convergence | {"qa_id":"medium_convergence_00054","source_qa_id":"medium_convergence_two_branch_equal_context_0716","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NUBP2 and HSPA1A share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00055 | LSM8 and USP4 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a ternary complex formation between two deubiquitinating enzymes and an adaptor that serves as a platform for substrate deubiquitination. For which disease is this protein reported as a biomarker? | Moyamoya disease | Medium | convergence | {"qa_id":"medium_convergence_00055","source_qa_id":"medium_convergence_two_branch_equal_context_1032","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"LSM8 and USP4 share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00056 | PIK3AP1 and DAG1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct interaction between a glycoprotein component of the dystrophin complex and an adapter protein involved in signal transduction. Which disease is linked to genomic alterations in this protein's... | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00056","source_qa_id":"medium_convergence_two_branch_equal_context_0728","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"PIK3AP1 and DAG1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00057 | MME and EGFR share more than one reported protein partner. Evidence concerning one of these shared proteins describes the immunoprecipitation of a phosphoprotein with a specific antibody to confirm its identity as a src-related kinase. Which disease is linked to genomic alterations in this protein's gene? | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00057","source_qa_id":"medium_convergence_two_branch_equal_context_0415","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"MME and EGFR share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00058 | ENAH, VASP, and ABL1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes direct binding of c-Abl SH3 domain to a proline-rich site in the Arg C-terminal region. Which disease is associated with this protein? | adenoviridae infectious disease | Medium | convergence | {"qa_id":"medium_convergence_00058","source_qa_id":"medium_convergence_three_branch_context_0309","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ENAH, VASP, and ABL1 share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00059 | ZNF366 and SNAI1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes TPA triggering association of EGR-1 with Snail or SP-1 via immunoprecipitation and western blotting. Which disease is linked to genomic alterations ... | myocardial infarction | Medium | convergence | {"qa_id":"medium_convergence_00059","source_qa_id":"medium_convergence_two_branch_unequal_context_0975","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"ZNF366 and SNAI1 have overlapping extended protein-interaction neighborhoods containing se... | |
medium_convergence_00060 | LRIG3 and SNCA have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes selective interaction of a synuclein protein with neurotrophic receptors leading to inhibited signaling and subsequent neuronal death. Which disease i... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_00060","source_qa_id":"medium_convergence_two_branch_unequal_context_0788","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"LRIG3 and SNCA have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00061 | DOK7 and NEDD9 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes specific binding of a kinase to a proline-rich sequence at the C-terminus of an adaptor protein. Which disease is linked to genomic alterations in thi... | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00061","source_qa_id":"medium_convergence_two_branch_unequal_context_0357","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"DOK7 and NEDD9 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00062 | USP26 and TP53 share more than one reported protein partner. Evidence concerning one of these shared proteins describes an elongation factor coimmunoprecipitating in a salt stable complex with a tumor suppressor protein. For which disease is this protein reported as a biomarker? | myocardial ischemia | Medium | convergence | {"qa_id":"medium_convergence_00062","source_qa_id":"medium_convergence_two_branch_equal_context_0408","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"USP26 and TP53 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00063 | Several genes responsive to Rhinovirus A exposure encode proteins within the extended interaction neighborhood of RGS6. Expression data distinguish one of these genes: it was upregulated in cytotoxic T cells with a log2 fold-change of about 1.22 and an adjusted p-value of about 0.0078. Which disease is linked to genomi... | Squamous cell carcinoma of the head and neck | Medium | convergence | {"qa_id":"medium_convergence_00063","source_qa_id":"medium_convergence_two_branch_unequal_context_1222","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Rhinovirus A exposure encode proteins within the extended inte... | |
medium_convergence_00064 | C1orf86 and MCL1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes how a viral protein motif interacts with an E3 ligase to competitively inhibit binding of an anti-apoptotic protein. For which disease is this protein reported as a biomarker? | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_00064","source_qa_id":"medium_convergence_two_branch_equal_context_0646","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"C1orf86 and MCL1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00065 | ADRBK2 and MAP3K5 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes physical association of beta-Arrestins with the C-terminal domain of an apoptosis signal-regulating kinase. Which disease is associated with this p... | melanoma | Medium | convergence | {"qa_id":"medium_convergence_00065","source_qa_id":"medium_convergence_two_branch_unequal_context_0945","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"ADRBK2 and MAP3K5 have overlapping extended protein-interaction neighborhoods containing s... | |
medium_convergence_00066 | INSRR and SOCS3 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the direct physical interaction between a suppressor of cytokine signaling protein and the cytoplasmic regions of activated insulin-like growth factor and insulin receptors. Which disease has a thera... | prostate adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00066","source_qa_id":"medium_convergence_two_branch_equal_context_0178","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"INSRR and SOCS3 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00067 | INSRR, SOCS1, and EGFR share more than one reported protein partner. Evidence concerning one of these shared proteins describes a strong physical interaction between a suppressor of cytokine signaling protein and an insulin-like growth factor receptor detected via yeast two-hybrid assay. Which disease has a therapeutic... | prostate adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00067","source_qa_id":"medium_convergence_three_branch_context_0137","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"INSRR, SOCS1, and EGFR share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00068 | ZKSCAN8 and HDAC6 share more than one reported protein partner. Evidence concerning one of these shared proteins describes two ribosomal proteins being detected within an immunocomplex of a histone deacetylase isolated from stressed cells. Which disease is linked to genomic alterations in this protein's gene? | malignant peripheral nerve sheath tumor | Medium | convergence | {"qa_id":"medium_convergence_00068","source_qa_id":"medium_convergence_two_branch_equal_context_0625","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"ZKSCAN8 and HDAC6 share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00069 | CD22 and KHDRBS1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the identification of high confidence ligands for a rna binding protein including members of the src kinase family and other binders. Which disease is linked to genomic alterations in this protein's... | diffuse large B-cell lymphoma | Medium | convergence | {"qa_id":"medium_convergence_00069","source_qa_id":"medium_convergence_two_branch_equal_context_0412","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CD22 and KHDRBS1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00070 | CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one of these shared proteins describes specific direct binding of adaptor molecules to a regulatory protein in the cytoplasm to participate in its regulation. Which disease is linked to genomic alterations in this protein's gene? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00070","source_qa_id":"medium_convergence_two_branch_equal_context_0725","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CD22 and CDKN1B share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00071 | West Nile virus and Zaire ebolavirus alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a retinal pigment epithelium cell line with a log2 fold-change of about 6.22 and an adjusted p-value of about 0.00047. For which disease is this gene reported as a ... | asthma | Medium | convergence | {"qa_id":"medium_convergence_00071","source_qa_id":"medium_convergence_two_branch_equal_context_1118","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Zaire ebolavirus alter the expression of several genes in common. Expressi... | |
medium_convergence_00072 | HECW2 and NUP50 share more than one reported protein partner. Evidence concerning one of these shared proteins describes an interaction between an E3 ubiquitin ligase and a proliferating cell nuclear antigen via a canonical motif. For which disease is this protein reported as a biomarker? | histiocytic sarcoma | Medium | convergence | {"qa_id":"medium_convergence_00072","source_qa_id":"medium_convergence_two_branch_equal_context_0353","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"HECW2 and NUP50 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00073 | ZNF281, ELMSAN1, and GCN1L1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a zinc finger protein physically interacting with three core transcription factors essential for maintaining pluripotency in stem cells. Which disease has a causal association with this p... | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00073","source_qa_id":"medium_convergence_three_branch_context_0214","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZNF281, ELMSAN1, and GCN1L1 share more than one reported protein partner. Evidence concerning one of t... | |
medium_convergence_00074 | IGFBP3 and RBM14 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a drug-induced complex formation between a DNA/RNA-binding protein and its dimerization partner with an insulin-like growth factor binding protein in basal-like breast cancer cells. For which diseas... | kidney neoplasm | Medium | convergence | {"qa_id":"medium_convergence_00074","source_qa_id":"medium_convergence_two_branch_equal_context_0100","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"IGFBP3 and RBM14 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00075 | NPHP1 and HSP90AB1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes filamin family actin-binding proteins interacting with the NHD domain identified via two-hybrid screen and coimmunoprecipitation. For which disease is this protein reported as a biomarker? | FG syndrome | Medium | convergence | {"qa_id":"medium_convergence_00075","source_qa_id":"medium_convergence_two_branch_equal_context_0937","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NPHP1 and HSP90AB1 share more than one reported protein partner. Evidence concerning one of th... | |
medium_convergence_00076 | CLEC1B and JAK1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the reported association between a specific scaffold protein and the cytoplasmic tail of CLEC-2 in this study. Which disease is linked to genomic alterations in this protein's gene? | hepatocellular carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00076","source_qa_id":"medium_convergence_two_branch_equal_context_0698","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"CLEC1B and JAK1 share more than one reported protein partner. Evidence concerning one of these... | |
medium_convergence_00077 | ZMYND19 and HDAC6 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the physical interaction between beta-tubulin and a histone deacetylase enzyme demonstrated through yeast two-hybrid assays and in vitro experiments. Which disease is linked to genomic alterations ... | scoliosis | Medium | convergence | {"qa_id":"medium_convergence_00077","source_qa_id":"medium_convergence_two_branch_equal_context_0071","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"ZMYND19 and HDAC6 share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00078 | PIK3AP1 and ABL1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes phosphorylation by a kinase inducing the binding of an adaptor protein to a specific tyrosine residue on an oncogene product. Which disease is linked to genomic alterations in this protein's gene? | schizophrenia | Medium | convergence | {"qa_id":"medium_convergence_00078","source_qa_id":"medium_convergence_two_branch_equal_context_0730","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"PIK3AP1 and ABL1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00079 | TRIO and SNCA share more than one reported protein partner. Evidence concerning one of these shared proteins describes the interaction between a guanine nucleotide exchange factor domain and an actin-crosslinking protein along with their cellular colocalization. For which disease is this protein reported as a biomarker... | FG syndrome | Medium | convergence | {"qa_id":"medium_convergence_00079","source_qa_id":"medium_convergence_two_branch_equal_context_0939","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"TRIO and SNCA share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00080 | ZCCHC3 and BRCA1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes stress-induced polyubiquitination of an RNA binding protein leading to its degradation via the proteasome pathway. Which disease is linked to genomic alterations in this protein's gene? | microcephalic primordial dwarfism, Alazami type | Medium | convergence | {"qa_id":"medium_convergence_00080","source_qa_id":"medium_convergence_two_branch_equal_context_0753","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"ZCCHC3 and BRCA1 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00081 | DCST1 and CCNE1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes how phosphorylation of a cyclin by its associated kinase allows binding to the receptor subunit of a ubiquitin ligase. For which disease is this prot... | glioblastoma | Medium | convergence | {"qa_id":"medium_convergence_00081","source_qa_id":"medium_convergence_two_branch_unequal_context_0905","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"DCST1 and CCNE1 have overlapping extended protein-interaction neighborhoods containing sev... | |
medium_convergence_00082 | Human respirovirus 3 and Human alphaherpesvirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a monocytic leukemia cell line with a log2 fold-change of about 1.74 and an adjusted p-value of about 0.011. For which disease is this gene reported as... | Borjeson-Forssman-Lehmann syndrome | Medium | convergence | {"qa_id":"medium_convergence_00082","source_qa_id":"medium_convergence_two_branch_equal_context_1244","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Human respirovirus 3 and Human alphaherpesvirus 1 alter the expression of several genes in com... | |
medium_convergence_00083 | ZNF281, ELMSAN1, and HNRNPA3 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a zinc finger protein physically interacting with three core transcription factors essential for maintaining pluripotency in stem cells. Which disease has a causal association with this ... | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00083","source_qa_id":"medium_convergence_three_branch_context_0239","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZNF281, ELMSAN1, and HNRNPA3 share more than one reported protein partner. Evidence concerning one of ... | |
medium_convergence_00084 | ZHX1, RELA, and USP7 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a specific binding interaction between a transcription factor and a deubiquitination enzyme involved in protein regulation. For which disease is this protein reported as a biomarker? | carcinoma of esophagus | Medium | convergence | {"qa_id":"medium_convergence_00084","source_qa_id":"medium_convergence_three_branch_context_0328","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"ZHX1, RELA, and USP7 share more than one reported protein partner. Evidence concerning one of these sh... | |
medium_convergence_00085 | Several genes responsive to Rhinovirus A exposure encode proteins within the extended interaction neighborhood of MLLT4. Expression data distinguish one of these genes: it was downregulated in bronchial epithelial cells with a log2 fold-change of about -1.21 and an adjusted p-value of about 0.021. For which disease is ... | non-small cell lung carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00085","source_qa_id":"medium_convergence_two_branch_unequal_context_1180","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Rhinovirus A exposure encode proteins within the extended inte... | |
medium_convergence_00086 | AKAP8L, LMNA, and MYC share more than one reported protein partner. Evidence concerning one of these shared proteins describes the physical interaction between a nuclear matrix protein and a nuclear lamina protein with the binding site located at the carboxy terminus. Which disease is linked to genomic alterations in t... | amyotrophic lateral sclerosis | Medium | convergence | {"qa_id":"medium_convergence_00086","source_qa_id":"medium_convergence_three_branch_context_0673","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"AKAP8L, LMNA, and MYC share more than one reported protein partner. Evidence concerning one of these s... | |
medium_convergence_00087 | West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in dendritic cells with a log2 fold-change of about 5.12 and an adjusted p-value of about 0.014. For which disease is this gene reported as a biomarker? | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00087","source_qa_id":"medium_convergence_two_branch_equal_context_1108","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human betaherpesvirus 5 alter the expression of several genes in common. E... | |
medium_convergence_00088 | Vaccinia virus and Human orthopneumovirus alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in cytotoxic T cells with a log2 fold-change of about 1.04 and an adjusted p-value of about 0.033. For which disease is this gene reported as a biomarker? | colorectal carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00088","source_qa_id":"medium_convergence_two_branch_equal_context_1143","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"Vaccinia virus and Human orthopneumovirus alter the expression of several genes in common. Exp... | |
medium_convergence_00089 | GLP1R, CKAP4, and DPP4 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the validation of three novel interactors for a glucagon-like peptide one receptor using co-immunoprecipitation fluorescence resonance energy transfer and immunofluorescence. For which disease... | Alzheimer disease | Medium | convergence | {"qa_id":"medium_convergence_00089","source_qa_id":"medium_convergence_three_branch_context_0505","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"GLP1R, CKAP4, and DPP4 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00090 | CDH16 and CAV1 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes reduction in coimmunoprecipitation and plasma membrane colocalization between a caveolar protein and a signaling molecule by prostaglandin E2. Which d... | proteinuria | Medium | convergence | {"qa_id":"medium_convergence_00090","source_qa_id":"medium_convergence_two_branch_unequal_context_0291","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"CDH16 and CAV1 have overlapping extended protein-interaction neighborhoods containing seve... | |
medium_convergence_00091 | ADCYAP1R1 and TRAF6 have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes the specific requirement of an E3 ligase for kinase activation and its physical interaction with beta receptors via a homology domain. For which ... | nervous system disorder | Medium | convergence | {"qa_id":"medium_convergence_00091","source_qa_id":"medium_convergence_two_branch_unequal_context_0783","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"ADCYAP1R1 and TRAF6 have overlapping extended protein-interaction neighborhoods containing... | |
medium_convergence_00092 | West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in a melanoma cell line with a log2 fold-change of about 4.79 and an adjusted p-value of about 8e-15. Which disease is associated with this gene? | thrombocytopenia | Medium | convergence | {"qa_id":"medium_convergence_00092","source_qa_id":"medium_convergence_two_branch_equal_context_1089","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Human alphaherpesvirus 3 alter the expression of several genes in common. ... | |
medium_convergence_00093 | ZNF384 and ZNF281 share more than one reported protein partner. Evidence concerning one of these shared proteins describes physical interactions between a zinc finger protein and three core pluripotency transcription factors in cellular complexes. Which disease has a causal association with this protein? | papillary adenocarcinoma | Medium | convergence | {"qa_id":"medium_convergence_00093","source_qa_id":"medium_convergence_two_branch_equal_context_0574","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"ZNF384 and ZNF281 share more than one reported protein partner. Evidence concerning one of the... | |
medium_convergence_00094 | West Nile virus and Primate bocaparvovirus 1 alter the expression of several genes in common. Expression data distinguish one of these genes: it was upregulated in tracheobronchial epithelial cells with a log2 fold-change of about 1.27 and an adjusted p-value of about 0.041. For which disease is this gene reported as a... | osteoporosis | Medium | convergence | {"qa_id":"medium_convergence_00094","source_qa_id":"medium_convergence_two_branch_equal_context_1083","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"West Nile virus and Primate bocaparvovirus 1 alter the expression of several genes in common. ... | |
medium_convergence_00095 | Several genes responsive to Human polyomavirus 1 exposure encode proteins within the extended interaction neighborhood of PHLDA1. Expression data distinguish one of these genes: it was upregulated in renal epithelial cells with a log2 fold-change of about 1.06 and an adjusted p-value of about 0.018. Which disease is as... | arthritic joint disease | Medium | convergence | {"qa_id":"medium_convergence_00095","source_qa_id":"medium_convergence_two_branch_unequal_context_1042","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Human polyomavirus 1 exposure encode proteins within the exten... | |
medium_convergence_00096 | WRAP53 and CDC16 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a direct physical interaction between a helicase and a scaffold protein that enhances the helicase association with an E3 ligase at DNA breaks. For which disease is this protein reported as a biomar... | carcinoma | Medium | convergence | {"qa_id":"medium_convergence_00096","source_qa_id":"medium_convergence_two_branch_equal_context_0894","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"WRAP53 and CDC16 share more than one reported protein partner. Evidence concerning one of thes... | |
medium_convergence_00097 | NRF1 and HDAC1 share more than one reported protein partner. Evidence concerning one of these shared proteins describes the experimental confirmation of a molecular interaction using both immunoprecipitation and chromatin immunoprecipitation techniques to validate binding. Which disease is associated with this protein? | chondrosarcoma | Medium | convergence | {"qa_id":"medium_convergence_00097","source_qa_id":"medium_convergence_two_branch_equal_context_0211","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_equal_context","locator":"context","question":"NRF1 and HDAC1 share more than one reported protein partner. Evidence concerning one of these ... | |
medium_convergence_00098 | SERF2 and VHL have overlapping extended protein-interaction neighborhoods containing several shared proteins. Evidence concerning one of these shared proteins describes reduced protein interaction and subsequent ubiquitination resulting from the knockdown of a specific deubiquitinase. Which disease is associated with t... | osteoarthritis, knee | Medium | convergence | {"qa_id":"medium_convergence_00098","source_qa_id":"medium_convergence_two_branch_unequal_context_0414","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"SERF2 and VHL have overlapping extended protein-interaction neighborhoods containing sever... | |
medium_convergence_00099 | Several genes responsive to Rhinovirus A exposure encode proteins within the extended interaction neighborhood of RGS6. Expression data distinguish one of these genes: it was upregulated in cytotoxic T cells with a log2 fold-change of about 1.38 and an adjusted p-value of about 0.011. Which disease is linked to genomic... | intraepithelial neoplasia | Medium | convergence | {"qa_id":"medium_convergence_00099","source_qa_id":"medium_convergence_two_branch_unequal_context_1221","difficulty":"medium","subtype":"convergence","detailed_subtype":"two_branch_unequal_context","locator":"context","question":"Several genes responsive to Rhinovirus A exposure encode proteins within the extended inte... | |
medium_convergence_00100 | TP53INP1, NEK9, and CCT2 share more than one reported protein partner. Evidence concerning one of these shared proteins describes a molecular interaction mediated by a specific functional binding motif within the protein structure. For which disease is this protein reported as a biomarker? | hyperphosphatemia | Medium | convergence | {"qa_id":"medium_convergence_00100","source_qa_id":"medium_convergence_three_branch_context_0075","difficulty":"medium","subtype":"convergence","detailed_subtype":"three_branch_context","locator":"context","question":"TP53INP1, NEK9, and CCT2 share more than one reported protein partner. Evidence concerning one of thes... |
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