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12,200 | Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction. | Circulating growth differentiation factor 15 (GDF-15) levels correlate with heart mass and fibrosis; however, little is known about its value in predicting the prognosis of patients with heart failure with preserved ejection fraction (HFpEF).</AbstractText>We measured serum GDF-15 levels in 149 consecutive patients wit... |
12,201 | Electrophysiological and haemodynamic effects of vernakalant and flecainide in dyssynchronous canine hearts. | About one-third of patients with mild dyssynchronous heart failure suffer from atrial fibrillation (AF). Drugs that convert AF to sinus rhythm may further slowdown ventricular conduction. We aimed to investigate the electrophysiological and haemodynamic effects of vernakalant and flecainide in a canine model of chronic... |
12,202 | Implantable cardioverter-defibrillators for treatment of sustained ventricular arrhythmias in patients with Chagas' heart disease: comparison with a control group treated with amiodarone alone. | Evidence is inconclusive concerning the benefit of implantable cardioverter-defibrillators (ICDs) for secondary prevention of mortality in patients with Chagas' heart disease (ChHD). The aim of this study was to compare the outcomes of ChHD patients with life-threatening ventricular arrhythmias (VAs), who were treated ... |
12,203 | A diagnostic dilemma: early repolarization syndrome associated with ventricular fibrillation. | An early repolarization (ER) pattern, characterized by J-point elevation, slurring of the terminal part of the QRS and ST-segment elevation, is a common finding on the 12-lead electrocardiogram. It has been suggested that J-point elevation, which was considered benign for many years, may play a critical role in the pat... |
12,204 | The degree of left atrial structural remodeling impacts left ventricular ejection fraction in patients with atrial fibrillation. | The extent of left atrial (LA) wall structural remodeling (fibrosis) detected by late gadolinium enhancement-magnetic resonance imaging (LGE-MRI) is correlated with advanced atrial fibrillation (AF). The concomitant occurrence of AF and left ventricular (LV) dysfunction is not uncommon. We studied the effect of LA fibr... |
12,205 | Pharmacokinetics of pilsicainide hydrochloride for injection in healthy Chinese volunteers: a randomized, parallel-group, open-label, single-dose study. | Pilsicainide hydrochloride is a class IC antiarrhythmic agent used for the treatment of supraventricular and ventricular arrhythmias and atrial fibrillation.</AbstractText>The objective of the present study was to determine the pharmacokinetics (PK) of a pilsicainide hydrochloride injection in healthy Chinese adults. T... |
12,206 | Application of machine learning techniques to analyse the effects of physical exercise in ventricular fibrillation. | This work presents the application of machine learning techniques to analyse the influence of physical exercise in the physiological properties of the heart, during ventricular fibrillation. To this end, different kinds of classifiers (linear and neural models) are used to classify between trained and sedentary rabbit ... |
12,207 | Vasospastic angina and Ca channel blockers. | Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina (VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However... |
12,208 | Cardiac arrythmias: multimodal assessment integrating body surface ECG mapping into cardiac imaging. | To demonstrate the feasibility of comprehensive assessment of cardiac arrhythmias by combining body surface electrocardiographic (ECG) mapping (BSM) and imaging.</AbstractText>This study was approved by the institutional review board, and all patients gave written informed consent. Twenty-seven patients referred for el... |
12,209 | [Masquerading bundle branch block]. | We here describe a surface 12-lead electrocardiogram (ECG) of a 72-year-old female with a prior history of breast cancer and chemotherapy-induced cardiomyopathy. An echocardiogram revealed left ventricular dysfunction, ejection fraction of 23%, with mild enlarged left ventricle. The 12-lead ECG showed atrial fibrillati... |
12,210 | Cardiac acceleration at the onset of exercise: a potential parameter for monitoring progress during physical training in sports and rehabilitation. | There is a need for easy-to-use methods to assess training progress in sports and rehabilitation research. The present review investigated whether cardiac acceleration at the onset of physical exercise (HRonset) can be used as a monitoring variable. The digital databases of Scopus and PubMed were searched to retrieve s... |
12,211 | Multidetector computed tomography may be an adequate screening test to reduce periprocedural stroke in atrial fibrillation ablation: a multicenter propensity-matched analysis. | Whether routine transesophageal echocardiography (TEE) in addition to multidetector computed tomography (MDCT) has incremental value in preventing periprocedural stroke before atrial fibrillation (AF) ablation is unclear.</AbstractText>The purpose of this study was to evaluate whether screening with MDCT is sufficient ... |
12,212 | A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure. | Heart failure (HF) is associated with development of AF and life-threatening ventricular tachycardia and fibrillation (VT/VF). Vulnerability to development of AF and VT/VF at different stages of HF and the underlying pathophysiological mechanisms are poorly defined. The present study was designed to determine the time-... |
12,213 | Mechanism of reentry induction by a 9-V battery in rabbit ventricles. | Although the application of a 9-V battery to the epicardial surface is a simple method of ventricular fibrillation induction, the fundamental mechanisms underlying this process remain unstudied. We used a combined experimental and modelling approach to understand how the interaction of direct current (DC) from a batter... |
12,214 | Heart failure highlights in 2012-2013. | Heart failure has become the cardiovascular epidemic of the century. The European Journal of Heart Failure is dedicated to the advancement of knowledge in the field of heart failure management. In 2012 and 2013, several pioneering scientific discoveries and paradigm-shifting clinical trials have been published. In the ... |
12,215 | Evaluation of repolarization dynamics using the QT-RR regression line slope and intercept relationship during 24-h Holter ECG. | QT-RR linear regression consists of two parameters, slope and intercept, and the aim of this study was to evaluate repolarization dynamics using the QT-RR linear regression slope and intercept relationship during 24-h Holter ECG. This study included 466 healthy subjects (54.6 ± 14.6 years; 200 men and 266 women) a... |
12,216 | Circumstances and outcomes of out-of-hospital cardiac arrest in elementary and middle school students in the era of public-access defibrillation. |  Circumstances and outcomes of out-of-hospital cardiac arrest (OHCA) in elementary and middle school students while at school in the era of public-access defibrillation are unknown.</AbstractText> We conducted a nationwide hospital-based survey of elementary and middle school students who had had OHCA of ... |
12,217 | [Current indications for an implantable cardioverter defibrillator (ICD)]. | Sudden cardiac death is one of the leading causes of death in industrialized countries. The implantable cardioverter/defibrillator (ICD) is the most effective treatment for malignant ventricular tachyarrhythmias. Current guidelines recommend the implantation of a defibrillator in patients who experienced ventricular ta... |
12,218 | Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation. | Little is known about the mechanisms underlying the transition from paroxysmal to persistent atrial fibrillation (AF). In an ovine model of long-standing persistent AF we tested the hypothesis that the rate of electric and structural remodeling, assessed by dominant frequency (DF) changes, determines the time at which ... |
12,219 | Miniaturized mechanical chest compressor improves calculated cerebral perfusion pressure without compromising intracranial pressure during cardiopulmonary resuscitation in a porcine model of cardiac arrest. | One of the major goals of cardiopulmonary resuscitation (CPR) is to provide adequate oxygen delivery to the brain for minimizing cerebral injury resulted from cardiac arrest. The optimal chest compression during CPR should effectively improve brain perfusion without compromising intracranial pressure (ICP). Our previou... |
12,220 | Atrial fibrillation from the pathologist's perspective. | Atrial fibrillation (AF), the most common sustained cardiac arrhythmia encountered in clinical practice, is associated with increased morbidity and mortality. Electrophysiologically, it is characterized by a high rate of asynchronous atrial cell depolarization causing a loss of atrial contractile function and irregular... |
12,221 | Double simultaneous defibrillators for refractory ventricular fibrillation. | Out-of-hospital cardiac arrest is a leading cause of death in the United States. Ventricular fibrillation (VF) is the most common initial rhythm after cardiac arrest.</AbstractText>To describe a novel approach to the patient with intractable VF after cardiac arrest.</AbstractText>A 51-year old man presented in cardiac ... |
12,222 | Risk factors for progression of functional tricuspid regurgitation. | The aim of this study was to determine the risk factors for tricuspid regurgitation (TR) progression in a contemporary population of patients referred for echocardiography. In a case-control study, we compared 100 consecutive patients with TR progression on serial echocardiograms (trivial or mild TR on the first echoca... |
12,223 | Radiofrequency catheter ablation of atypical atrial flutter in dogs. | Five dogs were presented to our institution for fatigue caused by an incessant supraventricular tachycardia. In all dogs, an ECG on admission showed a narrow QRS complex tachycardia with a median ventricular cycle length of 220 ms (range 180-360 ms), and a positive atrial depolarization identifiable in the ST segment f... |
12,224 | Very early recurrence of Takotsubo syndrome. | An 82-year-old female presented lasting chest pain for stimulation and the ECG revealed ventricular fibrillation and ST segment elevation, so we considered acute myocardial infarction. However, after the clinical condition of the patient improved, symptoms recurred for stimulation again on day 4. An echocardiogram show... |
12,225 | Effect of mitral inflow pattern on diagnosis of severe mitral regurgitation in patients with chronic organic mitral regurgitation. | To determine sensitivity and specificity of E wave velocity in patients with severe chronic organic mitral regurgitation (MR) and normal left ventricular ejection fraction (EF) and to evaluate prevalence of A wave dominance in patients with severe MR.</AbstractText>We compared 35 patients with quantified severe, chroni... |
12,226 | Cardiac contractility modulation increases action potential duration dispersion and decreases ventricular fibrillation threshold via β1-adrenoceptor activation in the crystalloid perfused normal rabbit heart. | <AbstractText Label="BACKGROUND/OBJECTIVES" NlmCategory="OBJECTIVE">Cardiac contractility modulation (CCM) is a new treatment being developed for heart failure (HF) involving application of electrical current during the absolute refractory period. We have previously shown that CCM increases ventricular force through &#... |
12,227 | Outcome of prolonged ventricular fibrillation and CPR in a rat model of chronic ischemic left ventricular dysfunction. | Patients with chronic left ventricular (LV) dysfunction are assumed to have a lower chance of successful CPR and lower likelihood of ultimate survival. However, these assumptions have rarely been documented. Therefore, we investigated the outcome of prolonged ventricular fibrillation (VF) and CPR in a rat model of chro... |
12,228 | 3DQRS: a method to obtain reliable QRS complex detection within high field MRI using 12-lead electrocardiogram traces. | To develop a technique that accurately detects the QRS complex in 1.5 Tesla (T), 3T, and 7T MRI scanners.</AbstractText>During early systole, blood is rapidly ejected into the aortic arch, traveling perpendicular to the MRI's main field, which produces a strong voltage (V(MHD)) that eclipses the QRS complex. Greater co... |
12,229 | Devices for mitral valve repair. | The natural history of severe mitral regurgitation (MR) is unfavorable, leading to left ventricular failure, atrial fibrillation, stroke, and death. Many patients affected by severe regurgitation (MR) do not currently undergo surgery, mainly due to the perceived risk of the procedure (old age, impaired left ventricular... |
12,230 | Safety and tolerability of regadenoson CMR. | Knowledge of adverse events associated with regadenoson perfusion cardiac magnetic resonance (CMR) and patient tolerability has implications for patient safety and staff training. We sought to assess the safety and tolerability of regadenoson stress CMR.</AbstractText>A group of 728 consecutive patients (median age 58,... |
12,231 | Cardiac sarcoidosis: the Christchurch experience. | To present an overview of the diagnosis, treatment and outcomes of patients with cardiac sarcoidosis managed in Christchurch Hospital, New Zealand.</AbstractText>A retrospective review of patients with cardiac sarcoidosis at Christchurch Hospital from January 2005 to December 2012.</AbstractText>Eighteen patients were ... |
12,232 | The QT prolongation and clinical features in patients with takotsubo cardiomyopathy: Experiences of two tertiary cardiovascular centers. | There are few data regarding clinical characteristics, laboratory parameters, electrocardiographic and echocardiographic findings in takotsubo cardiomyopathy patients presenting with QT prolongation. Aim of this study was to investigate the differences in these parameters between takotsubo cardiomyopathy patients prese... |
12,233 | [Cardiac resynchronization therapy in patients with heart failure: a 10-year experience]. | Multiple randomized trials support the clinical benefits of cardiac resynchronization therapy (CRT) in patients with heart failure (HF) and ventricular dyssynchrony. Since the year 2000 this therapy has been increasingly used in Chile.</AbstractText>To describe the clinical characteristics and follow-up of HF patients ... |
12,234 | Tachycardia mediated cardiomyopathy: pathophysiology, mechanisms, clinical features and management. | Tachycardia mediated cardiomyopathy (TMC) is a reversible form of dilated cardiomyopathy that can occur with most supraventricular and ventricular arrhythmias. Despite the plethora of literature describing this entity in animal models, as well as humans, it remains poorly understood. Over the last decade, new etiologie... |
12,235 | Hypertrophic cardiomyopathy with intermittent free mitral regurgitation-a surgical dilemma. | We describe the case of a 52-year-old woman presenting with non-ST elevation myocardial infarction, atrial fibrillation, and a new diagnosis of hypertrophic cardiomyopathy. Transesophageal echocardiography following hemodynamic deterioration revealed completely restricted mitral leaflet motion with free mitral regurgit... |
12,236 | Safety and feasibility of concomitant surgical ablation of atrial fibrillation in patients with severely reduced left ventricular ejection fraction. | Concomitant surgical ablation of atrial fibrillation (AF) is a safe and feasible procedure. However, many surgeons are reluctant to perform it in patients with heart failure. We investigated the safety and efficacy of AF ablation in patients with a severely reduced left ventricular ejection fraction (LVEF <35%).</Ab... |
12,237 | [Device therapy after acute coronary syndrome]. | Acute coronary syndromes are seldom accompanied by high degree AV blocks. Implantation of a permanent pacemaker is rarely necessary.There is a high incidence of ventricular tachyarrhythmias during the acute phase of myocardial infarctions. Sustained VT or VF beyond 48 hours of the infarction indicate the need for an im... |
12,238 | A rare loss-of-function SCN5A variant is associated with lidocaine-induced ventricular fibrillation. | The human genome contains over 4 million variant sites, as compared with the reference genome, including rare sequence variants, which have the potential to exert large phenotypic effects, such as susceptibility to drug toxicity. We report identification and functional characterization of a rare non-synonymous (p.A1427... |
12,239 | Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity. | Rats selectively bred for inborn low capacity of running (LCR) display a series of poor health indices, whereas rats selected for high capacity of running (HCR) display a healthy profile. We hypothesized that selection of low aerobic capacity over generations leads to a phenotype with increased diastolic Ca(2+) leak th... |
12,240 | Impact of the presence and amount of myocardial fibrosis by cardiac magnetic resonance on arrhythmic outcome and sudden cardiac death in nonischemic dilated cardiomyopathy. | Current risk stratification for sudden cardiac death (SCD) in nonischemic dilated cardiomyopathy (NIDC) relies on left ventricular (LV) dysfunction, a poor marker of ventricular electrical instability. Contrast-enhanced cardiac magnetic resonance has the ability to accurately identify and quantify ventricular myocardia... |
12,241 | Atrial flutter with 1:1 conduction in undiagnosed Wolff-Parkinson-White syndrome. | Atrial flutter with 1:1 atrioventricular conduction via an accessory pathway is an uncommon presentation of Wolff-Parkinson-White syndrome not previously reported in the emergency medicine literature. Wolff-Parkinson-White syndrome, a form of ventricular preexcitation sometimes initially seen and diagnosed in the emerg... |
12,242 | Comparison of the safety and feasibility of arrhythmia ablation using the Amigo Robotic Remote Catheter System versus manual ablation. | The aim of this study is to evaluate the safety and feasibility of using the Amigo Remote Catheter System (RCS) in arrhythmia ablation procedures. Because Amigo allows the physician to operate all catheter function outside of the radiation field, operator exposure time was also evaluated. This is a nonrandomized, prosp... |
12,243 | Usefulness of right ventricular dysfunction to predict new-onset atrial fibrillation following coronary artery bypass grafting. | Postoperative atrial fibrillation (AF) is a serious yet common complication after coronary artery bypass grafting (CABG) surgery. Risk factors for postoperative AF have been identified, including echocardiographic parameters, and these are relied on to implement preventative strategies that reduce the incidence of AF. ... |
12,244 | Absolute survival after cardiac resynchronization therapy according to baseline QRS duration: a multinational 10-year experience: data from the Multicenter International CRT Study. | In the major trials of cardiac resynchronization therapy (CRT), the survival benefit of the therapy, relative to control subjects, increases with QRS duration. In the non-CRT heart failure population, however, a wide QRS duration is associated with a shorter survival. Relative survival benefit from a therapy, however, ... |
12,245 | Ablation of idiopathic ventricular fibrillation targeting short coupled ventricular premature contractions originating from a right ventricular papillary muscle. | We describe a 38-year-old male who experienced several episodes of syncope after having ventricular fibrillation. The electrocardiographic monitoring after his hospitalization revealed repetitive polymorphic ventricular tachycardias. All polymorphic ventricular tachycardias were consistently initiated by a short-couple... |
12,246 | The effects of the rate of postresuscitation rewarming following hypothermia on outcomes of cardiopulmonary resuscitation in a rat model. | To investigate the optimal rewarming rate following therapeutic hypothermia in a rate model of cardiopulmonary resuscitation. Both clinical and laboratory studies have demonstrated that mild therapeutic hypothermia following cardiopulmonary resuscitation improves myocardial and neurologic outcomes of cardiac arrest. Ho... |
12,247 | Ischaemic hepatitis precipitated by recurrent episodes of atrial fibrillation. | We report a case of ischaemic hepatitis associated with recurrent fast atrial fibrillation (AF) episodes in a 59-year-old male who presented with shortness of breath, nausea and vomiting. The patient had a history of ischaemic cardiomyopathy. An emergency electrocardiogram showed fast AF with a ventricular rate of 190 ... |
12,248 | Non-fluoroscopic catheter visualization using MediGuide™ technology: experience from the first 600 procedures. | A novel cardiovascular navigation system known as MediGuide™ (MG) which allows non-fluoroscopic catheter tracking over a background of pre-recorded cine loops was recently introduced. This system allows significant reduction of fluoroscopy exposure which is one of the potentially harmful aspects of today's elect... |
12,249 | [A man in his eighties with recurrent syncope]. | Syncope is usually a benign event that affects up to 50% of people over a lifetime, needing no extensive examination. The challenge is to diagnose the few with underlying life-threatening disease in need of immediate medical attention. Guidelines are clear, but unfortunately, clinical practice does not always follow re... |
12,250 | Feasibility and efficacy of mitral valve repair for degenerative mitral regurgitation in the elderly. | The number of elderly patients who require surgical treatment for mitral regurgitation (MR) is increasing. However, the feasibility and efficacy of mitral valve repair in elderly patients are unclear.</AbstractText>We retrospectively reviewed 55 patients, aged ≥75 years, who underwent mitral valve repair for deg... |
12,251 | Cellular mechanism underlying hypothermia-induced ventricular tachycardia/ventricular fibrillation in the setting of early repolarization and the protective effect of quinidine, cilostazol, and milrinone. | Hypothermia has been reported to induce ventricular tachycardia and fibrillation (VT/VF) in patients with early repolarization (ER) pattern. This study examines the cellular mechanisms underlying VT/VF associated with hypothermia in an experimental model of ER syndrome and examines the effectiveness of quinidine, cilos... |
12,252 | A study of early afterdepolarizations in a model for human ventricular tissue. | Sudden cardiac death is often caused by cardiac arrhythmias. Recently, special attention has been given to a certain arrhythmogenic condition, the long-QT syndrome, which occurs as a result of genetic mutations or drug toxicity. The underlying mechanisms of arrhythmias, caused by the long-QT syndrome, are not fully und... |
12,253 | Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. | Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role.</AbstractText>To define regional ion channel expression in myopathic hearts compared to normal hearts, and correlate expression to regional VF dyna... |
12,254 | Periodic limb movements during sleep and cardiac arrhythmia in older men (MrOS sleep). | To determine if periodic limb movements during sleep (PLMS) are associated with nocturnal cardiac arrhythmia.</AbstractText>2,793 community-dwelling older men underwent polysomnography with measurement of limb movements and EKG. Logistic regression assessed association of periodic limb movement index and periodic limb ... |
12,255 | Seizure secondary to cardiac arrythmias. | The relationship between seizure activity and arrhythmias is not well established. Sinus tachycardia is commonly seen post seizure. Bradyarrythmias leading to seizure activity is rarely reported in the literature thus far.</AbstractText>A 62-year-old lady presented with nocturnal seizures and was subsequently started o... |
12,256 | Assessment of atrial electromechanical delay using tissue Doppler echocardiography in children with asthma. | Right ventricular (RV) dysfunction, pulmonary hypertension, atrial enlargement, and cor pulmonale may be associated with asthma. These pathological conditions may disturb the electrophysiological properties of the right atrium. This study investigated the atrial electromechanical delay and P-wave dispersion (PWD) in pa... |
12,257 | Nav1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility. | Emerging evidences indicate that SCN10A/NaV1.8 is associated with cardiac conduction and atrial fibrillation, but the exact role of NaV1.8 in cardiac electrophysiology remains poorly understood. The present study was designed to investigate the effects of blocking NaV1.8 channels in cardiac ganglionated plexi (GP) on m... |
12,258 | Elevated plasma free fatty acids are associated with sudden death: a prospective community-based evaluation at the time of cardiac arrest. | In cohort studies, elevated levels of plasma nonesterified free fatty acids (NEFAs) have been associated with increased risk of sudden cardiac death (SCD) in men, but blood samples were drawn several years before SCD.</AbstractText>To confirm this relationship by evaluating levels of plasma NEFAs at the time of the SCD... |
12,259 | Active or passive pulmonary vein in atrial fibrillation: is pulmonary vein isolation always essential? | The role of pulmonary veins (PVs) in persistent atrial fibrillation (AF) perpetuation appears less important than in paroxysmal AF. Electrogram-based substrate ablation is not widely performed as a stand-alone strategy.</AbstractText>To evaluate PV activity in AF perpetuation and efficacy of our patient-tailored ablati... |
12,260 | Managed ventricular pacing compared with conventional dual-chamber pacing for elective replacement in chronically paced patients: results of the Prefer for Elective Replacement Managed Ventricular Pacing randomized study. | Several studies have shown that unnecessary right ventricular pacing has detrimental effects.</AbstractText>To evaluate whether minimization of ventricular pacing as compared with standard dual-chamber pacing (DDD) improves clinical outcomes in patients referred for pacemaker or implantable cardioverter-defibrillator (... |
12,261 | Absolute beat-to-beat variability and instability parameters of ECG intervals: biomarkers for predicting ischaemia-induced ventricular fibrillation. | Predicting lethal arrhythmia liability from beat-to-beat variability and instability (BVI) of the ECG intervals is a useful technique in drug assessment. Most investigators use only arrhythmia-free ECGs for this. Recently, it was shown that drug-induced torsades de pointes (TdP) liability can be predicted more accurate... |
12,262 | Application of a mortality risk score in a general population of patients with an implantable cardioverter defibrillator (ICD). | The implantable cardioverter defibrillator (ICD) is very effective in the prevention of sudden cardiac death, but its benefit is impaired by competing risks. A simple risk model to predict mortality was designed for patients with primary prevention and ischaemic cardiomyopathy. We aimed to apply this score to a general... |
12,263 | Comparison of heat donation through the head or torso on mild hypothermia rewarming. | The purpose of the study was to compare the effectiveness of head vs torso warming in rewarming mildly hypothermic, vigorously shivering subjects using a similar source of heat donation.</AbstractText>Six subjects (1 female) were cooled on 3 occasions in 8 ºC water for 60 minutes or to a core temperature of 35 &#x... |
12,264 | In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation. | Mutations in transmembrane domains of the KCNQ1 subunit of the I(Ks) potassium channel have been associated with familial atrial fibrillation. We have investigated mechanisms by which the S1 domain S140G KCNQ1 mutation influences atrial arrhythmia risk and, additionally, whether it can affect ventricular electrophysiol... |
12,265 | Short term administration of L-carnitine can be detrimental to the ischemic heart. | Previous studies have shown that L-carnitine (LC) supplementation may exert a cardioprotective effect in cardiomyopathy, prevent arrhythmias in myocardial infarction and increase exercise tolerance in angina. Interestingly, we demonstrated that short term preischemic administration of LC can be detrimental to ischemic ... |
12,266 | Marathon run: cardiovascular adaptation and cardiovascular risk. | The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the ... |
12,267 | Intravenous metoprolol versus diltiazem for rate control in noncardiac, nonthoracic postoperative atrial fibrillation. | Little guidance exists on effective management of postoperative atrial fibrillation (POAF) following noncardiac, nonthoracic (NCNT) surgery.</AbstractText>The purpose of this study was to identify whether a difference exists between intravenous (IV) metoprolol and diltiazem when used to achieve hemodynamically stable r... |
12,268 | The effect of mild left ventricular diastolic dysfunction on outcome after isolated coronary bypass surgery. | Although moderate to severe diastolic dysfunction (DD) seems to be associated with poor prognosis after isolated coronary bypass surgery, the impact of mild DD has not been investigated extensively in this group of patients.</AbstractText>We evaluated the prognostic implication of mild left ventricular (LV) DD on outco... |
12,269 | Brain natriuretic peptide: a biomarker for all cardiac disease? | To evaluate new development in the utility of brain natriuretic peptide and N-Terminal brain natriuretic peptide (BNP/NT-Pro-BNP) in the management of various cardiovascular diseases. The determination of plasma BNP levels has an established role in the discrimination of pulmonary oedema from other causes of acute dysp... |
12,270 | Dantrolene improves survival after ventricular fibrillation by mitigating impaired calcium handling in animal models. | Resistant ventricular fibrillation, refibrillation. and diminished myocardial contractility are important factors leading to poor survival after cardiac arrest. We hypothesized that dantrolene improves survival after ventricular fibrillation (VF) by rectifying the calcium dysregulation caused by VF.</AbstractText>VF wa... |
12,271 | Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. | Sudden cardiac death (SCD) is the leading global cause of mortality, exhibiting increased incidence in patients with diabetes mellitus. Ion channel gene perturbations provide a well-established ventricular arrhythmogenic substrate for SCD. However, most arrhythmia-susceptibility genes, including the KCNE2 K(+) channel ... |
12,272 | Resuscitation of a neonate with medium chain acyl-coenzyme a dehydrogenase deficiency using extracorporeal life support. | We report a neonate with medium chain acyl-coenzyme A dehydrogenase deficiency (MCAD) who had a cardiac arrest due to ventricular tachycardia and fibrillation. Extracorporeal life support (ECLS) was deployed, from which the baby was subsequently separated and discharged from hospital. This case was a rare neonatal pres... |
12,273 | Survival with good neurological outcome in a patient with prolonged ischemic cardiac arrest--utility of automated chest compression systems in the cardiac catheterization laboratory. | The management of refractory cardiac arrest during invasive coronary procedures has substantial logistical challenges and is typically associated with disappointing outcomes. We describe the case of a young woman with recalcitrant ventricular fibrillation due to acute anterior ST-elevation myocardial infarction caused ... |
12,274 | Multiple and recurrent coronary stent fractures. | Coronary stent fracture is an increasingly recognized complication mainly involving drug-eluting stents. Important clinical implications, including in-stent restenosis and stent thrombosis, have been associated with this phenomenon. Variable incidence rates and several predisposing factors have been reported, but no ge... |
12,275 | Use of novel oral anticoagulants in patients with heart failure. | Pathophysiologically, there is a prothrombotic state evident in heart failure (HF). This is particularly evident within atria in patients whose course of the disease is complicated by concomitant atrial fibrillation (AF). A predisposition for thrombogenesis exists in patients with dilated dysfunctional cardiac chambers... |
12,276 | Probability of a shockable presenting rhythm as a function of EMS response time. | Survival from cardiac arrest is associated with having a shockable presenting rhythm (VF/pulseless VT) upon EMS arrival. A concern is that several studies have reported a decline in the incidence of VF/PVT over the past few decades. One plausible explanation is that contemporary cardiovascular therapies, such as increa... |
12,277 | Osteopontin and galectin-3 predict the risk of ventricular tachycardia and fibrillation in heart failure patients with implantable defibrillators. | Myocardial extracellular matrix remodelling provides electrical heterogeneity entailing ventricular tachycardia/fibrillation (VT/VF) in heart failure (HF) patients. Osteopontin (OPN) and Galectin-3 (Gal-3) are fibrosis markers and may reflect the extension of the arrhythmogenic substrate. We assessed whether plasma OPN... |
12,278 | Gain-of-function KCNH2 mutations in patients with Brugada syndrome. | Brugada syndrome (BrS) is an inherited disease characterized by right precordial ST segment elevation on electrocardiograms (ECGs) that predisposes patients to sudden cardiac death as a result of polymorphic ventricular tachyarrhythmia or ventricular fibrillation (VF). In BrS patients, except for SCN5A, mutations in ot... |
12,279 | Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia. | Primary cardiac arrhythmias are often caused by defects, predominantly in the genes responsible for generation of cardiac electrical potential, i.e., cardiac rhythm generation. Due to the variability in underlying genetic defects, type, and location of the mutations and putative modifiers, clinical phenotypes could be ... |
12,280 | Profile of cardiac disease in Cameroon and impact on health care services. | Cardiovascular diseases (CVD) have emerged as a major public health problem and impose an escalating burden on the health care system in Cameroon. The aim of the study was to investigate the preparedness of health care services for patients presenting with CVD in general and specifically, in St. Elizabeth catholic gene... |
12,281 | Catheter ablation of ventricular fibrillation: importance of left ventricular outflow tract and papillary muscle triggers. | Monomorphic ventricular premature depolarizations (VPDs) have been found to initiate ventricular fibrillation (VF) or polymorphic ventricular tachycardia (PMVT) in patients with and without structural heart disease.</AbstractText>The purpose of this study was to describe and characterize sites of origin of VPDs trigger... |
12,282 | Predictors of long-term outcomes in patients with significant myxomatous mitral regurgitation undergoing exercise echocardiography. | Significant myxomatous mitral regurgitation leads to progressive left ventricular (LV) decline, resulting in congestive heart failure and death. Such patients benefit from mitral valve surgery. Exercise echocardiography aids in risk stratification and helps decide surgical timing. We sought to assess predictors of outc... |
12,283 | Cardioembolic stroke: practical considerations for patient risk management and secondary prevention. | Cardioembolic (CE) stroke constitutes approximately 20% of all occurrence of ischemic stroke in patients. Atrial fibrillation remains the most common and most studied mechanism underlying CE stroke events. Cardioembolic strokes carry high morbidity and are associated with early recurrence in patients. Our understanding... |
12,284 | Predictors of severe tricuspid regurgitation in patients with permanent pacemaker or automatic implantable cardioverter-defibrillator leads. | Patients with permanent pacemaker or automatic implantable cardioverter-defibrillator (AICD) leads have an increased prevalence of tricuspid regurgitation. However, the roles of cardiac rhythm and lead-placement duration in the development of severe tricuspid regurgitation are unclear. We reviewed echocardiographic dat... |
12,285 | Changes in medication preceding out-of-hospital cardiac arrest where resuscitation was attempted. | To describe recent changes in medication preceding out-of-hospital cardiac arrest (OHCA) where resuscitation was attempted.</AbstractText>OHCA victims were identified by the Swedish Cardiac Arrest Register and linked by means of their unique 10-digit personal identification numbers to the Prescribed Drug Register. We i... |
12,286 | Comparison of nifekalant and amiodarone for resuscitation of out-of-hospital cardiopulmonary arrest resulting from shock-resistant ventricular fibrillation. | Nifekalant is a pure potassium channel blocker that has been used to treat ventricular tachyarrhythmias since 1999 in Japan. Intravenous amiodarone was approved later than nifekalant in Japan, and it is still unclear which of the two agents is superior. The aim of this study was to compare the efficacy of nifekalant an... |
12,287 | ST-elevation myocardial infarction diagnosed after hospital admission. | Treatment times for ST-elevation myocardial infarction (STEMI) patients presenting to percutaneous coronary intervention hospitals have improved dramatically over the past 10 years, particularly for patients using emergency medical services. Limited data exist regarding treatment times and outcomes for patients who dev... |
12,288 | Piceatannol facilitates conduction block and ventricular fibrillation induction in ischemia-reperfused rabbit hearts with pacing-induced heart failure. | Piceatannol, a hydroxystilbene natural product, has been reported to exert antiarrhythmic action via INa inhibition and slow INa inactivation in ischemia-reperfused (IR) rat hearts. The present study aimed to clarify the proarrhythmic property of piceatannol during regional IR injury in failing rabbit hearts.</Abstract... |
12,289 | Ventricular fibrillation in a patient with tachycardia-induced cardiomyopathy after liver transplantation. | We report a case of atrial fibrillation-related tachycardia induced cardiomyopathy and ventricular fibrillation after liver transplantation in a 41-year-old man with end-stage liver failure. Atrial fibrillation and congestive heart failure occurred postoperatively. Cardiac arrests due to ventricular fibrillation occurr... |
12,290 | Comparison of 24-hour Holter monitoring with 14-day novel adhesive patch electrocardiographic monitoring. | Cardiac arrhythmias are remarkably common and routinely go undiagnosed because they are often transient and asymptomatic. Effective diagnosis and treatment can substantially reduce the morbidity and mortality associated with cardiac arrhythmias. The Zio Patch (iRhythm Technologies, Inc, San Francisco, Calif) is a novel... |
12,291 | Organizational index mapping to identify focal sources during persistent atrial fibrillation. | Localized rotors have been implicated in the mechanism of persistent atrial fibrillation (AF). Although regions of highest dominant frequency (DF) on spectral analysis of the left atrium (LA) have been said to identify rotors, other mechanisms such as wavefront collisions will sporadically also generate an inconsistent... |
12,292 | Stroke and thrombus formation appending to the MitraClip: what is the appropriate anticoagulation regimen? | Percutaneous mitral valve repair with the MitraClip system (Abbot Vascular, USA) is a promising technique for the non-surgical treatment of mitral regurgitation in special situations. The case is reported of a 72-year-old patient with history of atrial fibrillation and a severely impaired left ventricular function who ... |
12,293 | Takotsubo cardiomyopathy after minimally invasive mitral valve surgery: clinical case and review. | A sudden, unexpected, reversible, severe left ventricular dysfunction, mimicking an acute myocardial infarction without demonstrable obstructive coronary artery stenosis, was first recognized in Japan in 1990 and originally termed takotsubo cardiomyopathy. In 2006, the American Heart Association included takotsubo card... |
12,294 | Minimally invasive mitral valve reconstruction on the fibrillating heart for high-risk patients. | Mitral valve surgery after previous cardiac surgery is technically demanding and risky. In patients after coronary artery bypass grafting (CABG), mitral valve surgery is associated with a high risk of injury to the bypass graft with concomitant myocardial ischemia. An aortic valve prosthesis usually severely impairs ac... |
12,295 | A randomized controlled trial of catheter ablation versus medical treatment of atrial fibrillation in heart failure (the CAMTAF trial). | Restoring sinus rhythm in patients with heart failure (HF) and atrial fibrillation (AF) may improve left ventricular (LV) function and HF symptoms. We sought to compare the effect of a catheter ablation strategy with that of a medical rate control strategy in patients with persistent AF and HF.</AbstractText>Patients w... |
12,296 | Quantitative assessment of the effects of therapeutic hypothermia on early repolarization in idiopathic ventricular fibrillation survivors: a 7-year cohort study. | The early repolarization (ER) pattern on ECG is associated with an increased risk of idiopathic ventricular fibrillation (ID-VF). Hypothermia is known to result in similar electrocardiographic changes. In this retrospective cohort study, we examine the impact of therapeutic hypothermia on ER in survivors of cardiac arr... |
12,297 | Long-term arrhythmia-free survival in patients with severe left ventricular dysfunction and no inducible ventricular tachycardia after myocardial infarction. | A negative electrophysiology study (EPS) may delineate a subgroup of patients with severely impaired left ventricular ejection fraction (LVEF) whose care can be safely managed long-term without an implantable cardioverter-defibrillator.</AbstractText>Consecutive patients treated with primary percutaneous coronary inter... |
12,298 | [Ambulatory Electrocardiogram In Stroke Patients At The University Hospital Of Brazzaville: 81 Cases]. | To assess the value of Holter ECG in the assessment of patients experiencing ischemic stroke.</AbstractText>This was a prospective descriptive study conducted in the Department of Neurology of the University Hospital Center in Brazzaville between June 2011 and June 2012.</AbstractText>There were 53 men (63.9%) and 30 w... |
12,299 | Is There a Role for Tissue Doppler Imaging in Infective Endocarditis? | An 87-year-old woman was admitted to our Cardiology Department with symptoms and signs of acute congestive heart failure and fever. She had a long history of hypertension and chronic atrial fibrillation. Transthoracic echocardiography showed a large (>10 mm) and mobile mitral valve vegetation, prolapsing into the le... |
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