Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,324,700 | Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. | Recent studies in adult and weanling rats show that dietary fat, in close association with circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling food intake and body weight. In the present study, we examined the possibility that a fat-rich diet during pregnancy alters the develop... |
2,324,701 | microRNA-138 modulates cardiac patterning during embryonic development. | Organ patterning during embryonic development requires precise temporal and spatial regulation of protein activity. microRNAs (miRNAs), small noncoding RNAs that typically inhibit protein expression, are broadly important for proper development, but their individual functions during organogenesis are largely unknown. W... |
2,324,702 | ["Benign" intracranial hypertension: neuroradiology and endovascular treatments]. | Neuroimaging is useful in benign intracranial hypertension (BIH), contributing to its diagnosis criteria and ruling out other causes of intracranial hypertension. CT and/or MR results may be normal or may show small ventricles, an empty sella, or more frequently optic nerve sheath dilatation. Diffusion as well as perfu... |
2,324,703 | Normal sonographic development of the central nervous system from the second trimester onwards using 2D, 3D and transvaginal sonography. | The developmental changes of the fetal central nervous system (CNS) during the second and third trimesters, specifically the brain, relate mostly to changes in size. However, other changes do occur in the fetal brain during the second and third trimester such as: the union of the cerebellar hemispheres, development of ... |
2,324,704 | A restricted neuroendoscopic approach for pathological diagnosis of intraventricular and paraventricular tumours. | There is increasing interest in the use of neuroendoscopic techniques in neuro-oncology. We report our experience of endoscopic biopsy in patients harbouring intraventricular and paraventricular brain tumours in order to define criteria for the use of this technique.</AbstractText>We identified 23 patients (aged 7-78 y... |
2,324,705 | Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction. | Myocardial infarction (MI) and subsequent adverse remodeling cause heart failure. Previously we demonstrated a role for Kit ligand (KL) in improving cardiac function post-MI. KL has two major isoforms; KL-1 is secreted whereas KL-2 is predominantly membrane bound. We demonstrate here first that KL-2-deficient mice have... |
2,324,706 | CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. | Bone morphogenetic proteins such as BMP4 are essential for proper development of telencephalic forebrain structures and induce differentiation of telencephalic neural stem cells into a variety of cellular fates, including astrocytic, neuronal, and mesenchymal cells. Little is yet understood regarding the mechanisms tha... |
2,324,707 | Unique features of non-compaction of the ventricular myocardium in Arab and African patients.<Pagination><StartPage>241</StartPage><EndPage>245</EndPage><MedlinePgn>241-5</MedlinePgn></Pagination><Abstract><AbstractText>Non-compaction of the ventricular myocardium (NCVM) is an under-diagnosed cardiomyopathy. Patients d... | Non-compaction of the ventricular myocardium (NCVM) is an under-diagnosed cardiomyopathy. Patients diagnosed with NCVM at the King Abdulaziz Cardiac Centre, Riyadh, KSA from January 2000 to July 2004 and at the Sudan Heart Centre from August 2004 to July 2007 were included. Fifty-two patients with NCVM were identified ... |
2,324,708 | Role of heme oxygenase-1 in the cardioprotective effects of erythropoietin during myocardial ischemia and reperfusion. | We have recently demonstrated that erythropoietin (EPO) protects cardiomyocytes from apoptosis during myocardial ischemia-reperfusion (I/R). The objective of the present study was to investigate the role of heme oxygenase (HO)-1 in the antiapoptotic effects of EPO. Primary cultures of neonatal mouse cardiomyocytes were... |
2,324,709 | Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. | Periventricular heterotopia (PH) is a disorder characterized by neuronal nodules, ectopically positioned along the lateral ventricles of the cerebral cortex. Mutations in either of two human genes, Filamin A (FLNA) or ADP-ribosylation factor guanine exchange factor 2 (ARFGEF2), cause PH (Fox et al. in 'Mutations in fil... |
2,324,710 | [Childhood medulloblastoma]. | Medulloblastoma is one of the most common malignant childhood brain tumors. It is a primitive neuroectodermal tumor (PNET) and predominantly arises in the cerebellum and 4th ventricle. Most cases of medulloblastoma are sporadic, but some predisposition syndromes are known, such as SUFU and Gorlin syndromes. Most often ... |
2,324,711 | Segmental wall motion classification in echocardiograms using compact shape descriptors. | Parametric shape representations of endocardial contours, obtained with principal component analysis (PCA) and the orthomax criterion, provide compact descriptors for classifying segmental left ventricular wall motion.</AbstractText>Endocardial contours were delineated in the left ventricular echocardiograms of 129 pat... |
2,324,712 | The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid beta(1-40). | Amyloid beta (Abeta) peptide (1-40) can cause cognitive impairment.</AbstractText>We investigated whether dietary preadministration of eicosapentaenoic acid (EPA) is conducive to cognition learning ability and whether it protects against the impairment of learning ability in rats infused with Abeta peptide (1-40) into ... |
2,324,713 | Maturational and growth-related changes in left ventricular longitudinal strain and strain rate measured by two-dimensional speckle tracking echocardiography in healthy pediatric population. | We aimed to evaluate myocardial strain and strain rate (SR) by novel 2-dimensional speckle tracking echocardiography in a large pediatric cohort (1) to establish their normal values and (2) to discern the influence of maturation and cardiac growth on them.</AbstractText>Echocardiograms of 284 consecutive subjects of a ... |
2,324,714 | Hemodynamic failure as an indication to urgent liver transplantation in infants with giant hepatic hemangiomas or vascular malformations--report of four cases. | The aim of this study was to present acute hemodynamic failure as a rare indication for liver transplantation in neonates and infants with liver hemangiomatosis. We report four patients aged one to six months with giant liver hemangiomas, with huge arterio-venous shunting within these malformations. In three, many skin... |
2,324,715 | Changes in carbohydrate expression in the cervical spinal cord of rats during aging. | Aging is a process where histochemical changes occur. Some of these may consist of age-dependent loss of expression of some cell markers. Conversely, cell markers not expressed in young animals may be detectable in their older counterparts. Histochemical age changes in carbohydrate profiles in the spinal cord have not ... |
2,324,716 | Lethal effect of electric fields on isolated ventricular myocytes. | Defibrillator-type shocks may cause electric and contractile dysfunction. In this study, we determined the relationship between probability of lethal injury and electric field intensity (E in isolated rat ventricular myocytes, with emphasis on field orientation and stimulus waveform. This relationship was sigmoidal wit... |
2,324,717 | Incorporating temporal information into level set functional for robust ventricular boundary detection from echocardiographic image sequence. | Echocardiographic images often suffer from dropouts that lead to loss of signals on the ventricular boundary and cause the level set curve used to detect the boundary leaking out from the gaps on the boundary. In this paper, a novel method that incorporates temporal information into the level set functional is proposed... |
2,324,718 | Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly: a prospective study in a Japanese population. | We investigated if there are individuals at a preclinical stage of idiopathic normal pressure hydrocephalus (iNPH) in a general population. All the residents (n=1142) aged 61 years (n=306, men/women=156/150) and 70-72 years (n=836, men/women=356/480) in the two communities of Japan were requested to take brain MRI exam... |
2,324,719 | Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal. | Neural stem cells persist in the adult mammalian brain, within the subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ neural stem cell proliferation, self-renewal, and differentiation are not fully elucidated. In the present report, we describe a growth-stimulatory activity of liver explant-condition... |
2,324,720 | Hemodynamic performance of stage-2 univentricular reconstruction: Glenn vs. hemi-Fontan templates. | Flow structures, hemodynamics and the hydrodynamic surgical pathway resistances of the final stage functional single ventricle reconstruction, namely the total cavopulmonary connection (TCPC) anatomy, have been investigated extensively. However, the second stage surgical anatomy (i.e., bi-directional Glenn or hemi-Font... |
2,324,721 | Lead extraction: a new effective tool to overcome fibrous binding sites. | We report the case of a 50 year-old woman referred for extraction of an infected biventricular implantable cardioverter defibrillator (ICD) who underwent device and leads extraction. Due to adhesions at the level of the subclavian-innominate vein angle, manual traction with locking stylet was ineffective. A new mechani... |
2,324,722 | Chronic low-dose L-NAME treatment effect on cardiovascular system of borderline hypertensive rats: feedback regulation? | The effect of 8-week-lasting low-dose treatment of NG-Nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, was investigated in borderline hypertensive rats (BHR) to examine, whether dose of 1.5 mg/kg/day affects feedback regulation of NO synthesis.</AbstractText>Blood pressure (BP) of 12 week... |
2,324,723 | Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. | Neuromedin U-25 (NMU-25), a brain-gut peptide with anorexigenic actions, was paired with the G-protein-coupled receptors NMU1 and NMU2 in 2000. NMU-25 elicited a potent hypertensive effect in rats but little is known about its cardiovascular effects in humans. We examined the hypothesis that NMU fulfils the criteria fo... |
2,324,724 | Impact of natural sheep-goat transmission on detection and control of small ruminant lentivirus group C infections. | Dissemination of small ruminant lentivirus (SRLV) infections in Norway is affected by the different control strategies used for maedi-visna virus (MVV) infections in sheep and caprine arthritis-encephalitis virus (CAEV) infections in goats. Here we investigated SRLV phylogenetic group variants in sheep. CAEV-like isola... |
2,324,725 | PACAP27 regulates ciliary function in primary cultures of rat brain ependymal cells. | Ependymal cells line the brain ventricles and separate the CSF from the underlying neuronal tissue. The function of ependymal cilia is largely unclear however they are reported to be involved in the regulation of CSF homeostasis and host defence against pathogens. Here we present data that implicates a role of pituitar... |
2,324,726 | Biventricular noncompaction: a case report. | Myocardial noncompaction is an extremely uncommon cardiomyopathy. It can present as an isolated cardiac malformation or in association with other congenital anomalies. The left ventricle is usually affected, but a biventricular involvement rarely occurs. A predominant right ventricular involvement has not been reported... |
2,324,727 | Noncompaction myocardium imaging with multiple echocardiographic modalities. | Noncompaction myocardium of the left ventricle (LV) is a genetically heterogeneous congenital cardiomyopathy, that has only been described during the last two decades. Echocardiography plays a pivotal role as a first line diagnostic tool of this rare abnormality. The present case describes the imaging of the noncompact... |
2,324,728 | Effect of preload on left ventricular longitudinal strain by 2D speckle tracking. | Peak systolic longitudinal strain (PSLS) obtained using the 2D speckle tracking method is a novel indicator of the long-axis function of the left ventricle (LV). We used the 2D strain profile to examine the effect of preload reduction by hemodialysis (HD) on LV PSLS in patients with end-stage renal disease (ESRD).</Abs... |
2,324,729 | Assessment of systolic and diastolic left ventricular and left atrial function using vector velocity imaging in Takotsubo cardiomyopathy. | Five adult patients with Takotsubo cardiomyopathy (TC) diagnosed by usual criteria were studied with velocity vector imaging (VVI) on admission and at follow-up, when their LV function had improved, as assessed by 2D TTE wall-motion score (WMS) index. Averaged peak segmental longitudinal strain (S) in systole, and velo... |
2,324,730 | Distribution of beta-dystroglycan immunopositive globules in the subventricular zone of rat brain. | Present study demonstrates a novel localization of beta-dystroglycan in rat brain. Beside the meningeal surface and the cerebral vessels where beta-dystroglycan immunopositivity has been described, now immunopositive solid bodies were found at the basis of ependymocytes. Since they proved to be round in either coronal,... |
2,324,731 | Cerebellar ependymal cyst in a dog. | An 11-week-old, male, Staffordshire Bull Terrier had a history of generalized ataxia and falling since birth. The neurologic findings suggested a localization in the cerebellum. Magnetic resonance imaging of the brain was performed. In all sequences the area of the cerebellum was almost replaced by fluid isointense to ... |
2,324,732 | An active contour-based atlas registration model applied to automatic subthalamic nucleus targeting on MRI: method and validation. | This paper presents a new non parametric atlas registration framework, derived from the optical flow model and the active contour theory, applied to automatic subthalamic nucleus (STN) targeting in deep brain stimulation (DBS) surgery. In a previous work, we demonstrated that the STN position can be predicted based on ... |
2,324,733 | Passive ventricular mechanics modelling using MRI of structure and function. | Patients suffering from dilated cardiomyopathy or myocardial infarction can develop left ventricular (LV) diastolic impairment. The LV remodels its structure and function to adapt to pathophysiological changes in geometry and loading conditions and this remodeling process can alter the passive ventricular mechanics. In... |
2,324,734 | Evaluation of rigid and non-rigid motion compensation of cardiac perfusion MRI. | Although the evaluation of cardiac perfusion using MRI could be of crucial importance for the diagnosis of ischemic heart diseases, it is still not a routinely used technique. The major difficulty is that MR perfusion images are often corrupted by inconsistent myocardial motion. Although motion compensation methods hav... |
2,324,735 | Management of nosocomial external ventricular drain-related ventriculomeningitis. | Neurocritical care patients requiring external ventricular drainage are at risk for the development of a device-related infection. Infection rate of external ventriculostomy catheters is high with reported incidences ranging from 5% up to more than 20%. Nosocomial ventriculitis or ventriculomeningitis are potential lif... |
2,324,736 | Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain. | This study reports on the spatiotemporal dynamics of the expression of estrogen receptors (ERs) in the mouse central nervous system (CNS) during the early postnatal and the peripubertal period. At postnatal day 7 (P7), neurons with strong nuclear immunostaining for both ERalpha and ERbeta1 were widely distributed throu... |
2,324,737 | Resistance training and diastolic myocardial tissue velocities in obese children. | The primary purpose of this study was to determine the effects of resistance exercise training on early diastolic myocardial velocities (E') in an obese pediatric population.</AbstractText>Twenty-three obese adolescents were selected to participate in either a resistance-based training program (RT; n = 13, 12.2 +/- 0.4... |
2,324,738 | RAGE upregulation and nuclear factor-kappaB activation associated with ageing rat cardiomyocyte dysfunction. | Evidence suggests that ageing is a major risk factor for cardiac dysfunction. Interactions between advanced glycation endproducts (AGEs) and the receptor for AGEs (RAGE) are known to cause chronic cellular activation, including activation of nuclear factor-kappaB (NF-kappaB), which has been implicated as a causal facto... |
2,324,739 | Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. | Structural brain abnormalities have consistently been found in schizophrenia, with increased familial risk for the disease associated with these abnormalities. Some brain volume changes are progressive over the course of the illness. Whether these progressive brain volume changes are mediated by genetic or disease-rela... |
2,324,740 | N-terminal pro-B-type natriuretic peptide levels increases after hyperbaric oxygen therapy in diabetic patients. | Diabetic patients receive hyperbaric oxygen therapy for non-healing lower extremity ulcers. Exposure to hyperbaric hyperoxia during hyperbaric oxygen therapy may affect cardiovascular functions by different mechanisms. Patients may experience serious problems such as pulmonary edema and death during hyperbaric oxygen t... |
2,324,741 | Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. | Intracerebroventricular (i.c.v.) administration of colchicine, a microtubule-disrupting agent, causes cognitive dysfunction and oxidative stress. The present study was designed to investigate the protective effects of quercetin against colchicine-induced memory impairment and oxidative damage in rats. An i.c.v. cannula... |
2,324,742 | Spatio-temporal speckle reduction in ultrasound sequences. | In this paper we will be concerned with speckle removal in ultrasound images. To this end, we introduce a new spatio-temporal de-noising method based on a variational formulation. The regularization relies on a non parametric image model that describes the observed image structure and express inter-dependencies between... |
2,324,743 | Contractile analysis with kriging based on MR myocardial velocity imaging. | Diagnosis and treatment of coronary artery disease requires a full understanding of the intrinsic contractile mechanics of the heart. MR myocardial velocity imaging is a promising technique for revealing intramural cardiac motion but its ability to depict 3D strain tensor distribution is constrained by anisotropic voxe... |
2,324,744 | Epidemiology of peri/intraventricular haemorrhage in newborns at term. | Peri/intraventricular hemorrhage (PIVH) has significant consequences, particularly leading to cases of adverse neurodevelopment. The aim of this study was to asses the epidemiology of peri/intraventricular haemorrhage in newborns born at term. Study was designed and performed according to epidemiological model of case-... |
2,324,745 | Is necrotizing enterocolitis associated with development or progression of intraventricular hemorrhage? | An association between necrotizing enterocolitis (NEC) and poor neurodevelopmental outcome is increasingly recognized. A progression of preexisting intraventricular hemorrhage (IVH) or new IVH during an episode of NEC may be contributory. We investigated the incidence of IVH in infants with NEC. We performed an observa... |
2,324,746 | Involvement of cell-cell and cell-matrix interactions in bone destruction induced by metastatic MDA-MB-231 human breast cancer cells in nude mice. | To clarify the mechanisms of bone destruction associated with bone metastases, we studied an animal model in which inoculation of MDA-MB-231 human breast cancer cells into the left cardiac ventricle of female nude mice causes osteolytic lesions in bone using morphological techniques. On the bone surfaces facing the met... |
2,324,747 | Shared requirement for dynein function and intact microtubule cytoskeleton for normal surface expression of cardiac potassium channels. | Potassium channels at the cardiomyocyte surface must eventually be internalized and degraded, and changes in cardiac potassium channel expression are known to occur during myocardial disease. It is not known which trafficking pathways are involved in the control of cardiac potassium channel surface expression, and it i... |
2,324,748 | Inhalation of vasoactive intestinal peptide in pulmonary hypertension. | Pulmonary hypertension (PH) leads to an increased right ventricular workload, cardiac failure and death. In idiopathic pulmonary arterial hypertension (PAH) the vasodilating vasoactive intestinal peptide (aviptadil) is deficient. The aim of the present study was to test the acute effects on haemodynamics and blood gase... |
2,324,749 | Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium. | Reentrant arrhythmias often develop in the setting of myocardial infarction and ensuing slow propagation. Increased Na(+) channel expression could prevent or disrupt reentrant circuits by speeding conduction if channel availability is not limited by membrane depolarization within the diseased myocardium. We therefore a... |
2,324,750 | Measurements of ultrasonic attenuation properties of midgestational fetal pig hearts. | The objectives of this study were to measure the relative attenuation properties of the left and right ventricles in fetal pig hearts and to compare the spatial variation in attenuation measurements with those observed in previously published backscatter measurements. Approximately 1.0-mm-thick, short-axis slices of ex... |
2,324,751 | An unusual presentation of implantable cardioverter-defibrillator lead perforation. | Recently, there have been increased reports of implantable cardioverter-defibrillator (ICD) lead perforation. Controversy exists about the safety of certain leads.</AbstractText>A 37-year-old man with an ischemic cardiomyopathy presented four days postimplantation of an ICD lead with localized nonpleuritic chest wall p... |
2,324,752 | A new method for improving functional-to-structural MRI alignment using local Pearson correlation. | Accurate registration of Functional Magnetic Resonance Imaging (FMRI) T2-weighted volumes to same-subject high-resolution T1-weighted structural volumes is important for Blood Oxygenation Level Dependent (BOLD) FMRI and crucial for applications such as cortical surface-based analyses and pre-surgical planning. Such reg... |
2,324,753 | Combined endoscopic third ventriculostomy and choroid plexus cauterization as primary treatment of hydrocephalus for infants with myelomeningocele: long-term results of a prospective intent-to-treat study in 115 East African infants. | Shunt dependence is more dangerous for children in less developed countries. Combining endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) was previously shown to treat hydrocephalus more effectively than ETV alone in infants < 1 year of age. The goal of this prospective study was to evalu... |
2,324,754 | Failure to treat obstructive hydrocephalus with endoscopic third ventriculostomy in a patient with neurodegenerative Langerhans cell histiocytosis. | The second most frequent central nervous system involvement pattern in Langerhans cell histiocytosis (LCH) is a rare condition documented in a number of reports called "neurodegenerative LCH" (ND-LCH). Magnetic resonance images confirming the presence of the disease usually demonstrate striking symmetric bilateral hype... |
2,324,755 | Intraoperative assessment of endoscopic third ventriculostomy success. | The authors' aim in this study was to determine if standardizing the evaluation of intraoperative findings during endoscopic third ventriculostomy (ETV) could predict patients with hydrocephalus in whom endoscopic treatment will fail and require ventriculoperitoneal shunt treatment. The creation of a uniform scale with... |
2,324,756 | Sylvian aqueduct syndrome with slit ventricles in shunted hydrocephalus due to adult aqueduct stenosis. | The authors report on 3 patients who developed sylvian aqueduct syndrome (SAS) in the context of shunt dysfunction and slit ventricles. All 3 patients had received shunts for adult onset hydrocephalus due to aqueduct stenosis and were stable for years before presenting with loss of upward gaze, convergence-retraction n... |
2,324,757 | Three-dimensional constructive interference in steady-state magnetic resonance imaging in obstructive hydrocephalus: relevance for endoscopic third ventriculostomy and clinical results. | Endoscopic third ventriculostomy is the treatment of choice in patients with obstructive hydrocephalus caused by aqueductal stenosis. The authors examined the clinical course and results of surgical treatment for obstructive hydrocephalus with pre- and postoperative refined constructive interference in steady-state (CI... |
2,324,758 | Demonstration of uneven distribution of intracranial pulsatility in hydrocephalus patients. | Data from intracranial pressure (ICP) recordings in patients with hydrocephalus were reviewed to determine whether intracranial pulsatility within the cerebrospinal fluid (CSF) of cerebral ventricles (ICP(LV)) may differ from that within the brain parenchyma (ICP(PAR)), and whether pulsatility may differ between noncom... |
2,324,759 | Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. | The authors have shown that convection-enhanced delivery (CED) of gadoteridol-loaded liposomes (GDLs) into different regions of normal monkey brain results in predictable, widespread distribution of this tracking agent as detected by real-time MR imaging. They also have found that this tracking technique allows monitor... |
2,324,760 | Is the distance between mammillary bodies predictive of a thickened third ventricle floor? | Object The aim of this study was to correlate intraoperative endoscopic third ventriculostomy (ETV) findings in hydrocephalic patients with the MR imaging appearance of the mammillary bodies (MBs), the fundamental anatomical landmarks of the third ventricle floor (TVF) region. Methods The authors reviewed brain MR imag... |
2,324,761 | Intracranial epidermoid--a 10-year study. | Twenty-eight cases of intracranial epidermoids were operated over a period of 10 years at the Bangur Institute of Neurology, Kolkata; 17 of them were male and 11 were female with an age range of 11 to 55 (mean 28.21) years. Their locations include--cerebellopontine angle region (n = 15), fourth ventricle (n = 6), later... |
2,324,762 | [The effect of insulin on the spatial learning and memory abilities of the Alzheimer's disease model rats]. | To investigate the mechanism through which insulin affect the learning and memory abilities of the Alzheimer's disease-like rats.</AbstractText>Okadaic acid (OA) was injected into the CA1 region of the rat hippocampus and the insulin was injected into the lateral cerebral ventricle of the rats. The learning and memory ... |
2,324,763 | [Intracerebroventricular administration of adenosine A1 receptor antisense oligodeoxynucleotide inhibites the neuroprotective effect of the cerebral ischemic preconditioning in rats]. | To further explore the role of adenosine A1 receptor in the neuroprotective effect of cerebral ischemic preconditioning, the present study was undertaken to observe the effect of inhibiting expression of adenosine Al receptor with adenosine A1 receptor antisense oligodeoxynucleotide (ARA1 As-ODN) on the neuroprotective... |
2,324,764 | [The changes of funny currents in the ventricular myocytes of neonatal rats and adult rats]. | To record funny currents (If) of ventricular myocytes and to analysize hyperpolarization-activated cation channel(HCN) expression in the rats of different ages.</AbstractText>Fresh ventricular myocytes were isolated from 3 days rats and adult rats.HCN expressions were measured by real-time quantitative polymerase chain... |
2,324,765 | [Effects of genistein on contractility of isolated right ventricular muscles in guinea pig]. | To study the effect of genistein (GEN) on contractility of isolated right ventricular muscles in guinea pig and its mechanisms.</AbstractText>Isolated guinea pig ventricular muscles were suspended in organ baths containing K-H solution.After an equilibration period, the effect of GEN on contraction of myocardium was ob... |
2,324,766 | Potential effect of robust and simple IMRT approach for left-sided breast cancer on cardiac mortality. | Three-dimensional (3D) treatment planning has reduced the cardiac dose in postoperative radiotherapy for breast cancer; however, the overall cardiac toxicity is still an issue because of more aggressive adjuvant treatment. Toxicity models have suggested that a reduction of the heart volume treated to high doses might b... |
2,324,767 | Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats. | Intracerebral hemorrhage (ICH) usually affects older humans but almost no experimental studies have assessed aged animals. We address how aging alters inflammation, neuron death and lesion resolution after a hemorrhage in the rat striatum. In the normal aged brain, microglia displayed a 'dystrophic' phenotype, with sho... |
2,324,768 | Resection of ventricular rhabdomyomas in infants presenting with cardiac failure. | Rhabdomyomas are the most common cardiac tumours in children. They sometimes cause significant obstruction of the ventricular out flow tracts. We report a series of 3 neonates diagnosed antenatally with multiple rhabdomyomas, who developed significant obstruction of the ventricular outflow tracts following birth. They ... |
2,324,769 | [Left posterolateral extensive myocardial infarct. An electroanatomical comparison]. | A complete ECG thoracic circle allows exploring some heart structures not explored by the conventional electrocardiogram. It provides a direct indication on the location of the damaged myocardium. In fact, posterolateral infarctions can be limited to the inferior third of the left ventricle or can cover the entire free... |
2,324,770 | Highly k-t-space-accelerated phase-contrast MRI. | The purpose of this study was to combine a recently introduced spatiotemporal parallel imaging technique, PEAK-GRAPPA (parallel MRI with extended and averaged generalized autocalibrating partially parallel acquisition), with two-dimensional (2D) cine phase-contrast velocity mapping. Phase-contrast MRI was applied to me... |
2,324,771 | Pilomyxoid astrocytoma of the fourth ventricle in an adult. | Pilomyxoid astrocytomas have been identified as a variant of pilocytic astrocytoma. They are listed as a novel clinico-pathological entity in the 2007 World Health Organisation (WHO) classification of tumours of the central nervous system. This tumour corresponds to a WHO grade II neoplasm whereas pilocytic astrocytoma... |
2,324,772 | In Vivo 3D Digital Atlas Database of the Adult C57BL/6J Mouse Brain by Magnetic Resonance Microscopy. | In this study, a 3D digital atlas of the live mouse brain based on magnetic resonance microscopy (MRM) is presented. C57BL/6J adult mouse brains were imaged in vivo on a 9.4 Tesla MR instrument at an isotropic spatial resolution of 100 mum. With sufficient signal-to-noise (SNR) and contrast-to-noise ratio (CNR), 20 bra... |
2,324,773 | The brain expression of genes involved in inflammatory response, the ribosome, and learning and memory is altered by centrally injected lipopolysaccharide in mice. | Neuroinflammation plays a role in the progression of several neurodegenerative disorders. We used a lipopolysaccharide (LPS) model of neuroinflammation to characterize the gene expression changes underlying the inflammatory and behavioral effects of neuroinflammation. A single intracerebroventricular injection of LPS (... |
2,324,774 | Prenatal and postnatal follow-up of a fetal interhemispheric arachnoid cyst with partial corpus callosum agenesis, asymmetric ventriculomegaly and localized polymicrogyria. Case report. | We report a case of a fetal interhemispheric arachnoid cyst associated with partial callosal agenesis and asymmetric ventriculomegaly. After second trimester ultrasound diagnosis and evaluation, magnetic resonance imaging (MRI) at 28 weeks showed polymicrogyria laterally to the cyst. The parents decided to continue the... |
2,324,775 | Three-dimensional inversion rendering in the first- and early second-trimester fetal brain: its use in holoprosencephaly. | To explore the feasibility and added value of three-dimensional (3D) inversion rendering of the developing embryonic/fetal ventricular system, and to apply this display technique to enhance the sonographic examination of holoprosencephaly.</AbstractText>3D volumes of the embryonic/fetal brain were acquired from four no... |
2,324,776 | [Intracerebral bleeding as the first symptom of a congenital anaplastic astrocytoma]. | Anaplastic astrocytomas in neonates are extremely rare. Newborns, however, often have neuroectodermal central nervous tumours.</AbstractText>We report about a female term newborn (birth weight 3,600 g, APGAR 9/10/10), who had shrill screams, intermittent shivering and bradycardia. An ultrasound scan of the brain showed... |
2,324,777 | Acupuncture on the blood flow of various organs measured simultaneously by colored microspheres in rats. | We examined how acupuncture affected the blood flow of muscle, kidney, stomach, small intestine, brain, lung, heart, spleen and liver. Wistar rats anesthetized with urethane (n = 27) were allocated into the control (n = 10), ST-7 (Hsia-Kuan, n = 10) and LI-4 (Hoku, n = 7) groups. To measure organ blood flow, colored mi... |
2,324,778 | Noninvasive three-dimensional cardiac activation imaging from body surface potential maps: a computational and experimental study on a rabbit model. | Three-dimensional (3-D) cardiac activation imaging (3-DCAI) is a recently developed technique that aims at imaging the activation sequence throughout the the ventricular myocardium. 3-DCAI entails the modeling and estimation of the cardiac equivalent current density (ECD) distribution from which the activation time at ... |
2,324,779 | Three-dimensional cardiac strain estimation using spatio-temporal elastic registration of ultrasound images: a feasibility study. | Current ultrasound methods for measuring myocardial strain are often limited to measurements in one or two dimensions. Cardiac motion and deformation however are truly 3-D. With the introduction of matrix transducer technology, 3-D ultrasound imaging of the heart has become feasible but suffers from low temporal and sp... |
2,324,780 | Sparse registration for three-dimensional stress echocardiography. | Three-dimensional (3-D) stress echocardiography is a novel technique for diagnosing cardiac dysfunction. It involves evaluating wall motion of the left ventricle, by visually analyzing ultrasound images obtained in rest and in different stages of stress. Since the acquisitions are performed minutes apart, variabilities... |
2,324,781 | A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain. | Cells isolated from the ciliary body (CB) of the adult human eye possess properties of retinal stem/progenitor cells and can be propagated as spheres in culture. As these cells are isolated from a non-neural epithelium which has neuroepithelial origin, they may have both epithelial and neural lineages. Since it is the ... |
2,324,782 | Cardiac assistance from skeletal muscle: a reappraisal. | Cardiac assistance from skeletal muscle offers an attractive surgical solution to the problem of end-stage heart failure, yet it is widely regarded as a failed approach. I argue here that this is an outdated assessment. Systematic progress has been made over the last 25 years in understanding the relevant basic science... |
2,324,783 | Different Na+/K+-ATPase signal pathways was involved in the increase of [Ca2+]i induced by strophanthidin in normal and failing isolated guinea pig ventricular myocytes. | To determine whether different Na+/K+-ATPase signal transduction pathways have positive inotropic effects on normal ventricular myocytes (NC) and failing ventricular myocytes (FC), and are involved in an increase of [Ca2+]i induced by strophanthidin (Str).</AbstractText>A guinea pig model of congestive heart failure wa... |
2,324,784 | Centrally applied ghrelin affects feeding dynamics in male rats. | Ghrelin is 28-amino acid peptide, which is produced mainly in the stomach. Since plasma ghrelin are strictly dependent on food intake, this hormone has significant effects on appetite and energy balance. The aim of this investigation was to examine the effects of centrally applied ghrelin on feeding dynamism by measuri... |
2,324,785 | Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist. | The pathophysiological relevance of endothelial nitric-oxide synthase (eNOS)-induced superoxide production in cardiomyocyte injury after prolonged phenylephrine (PE) exposure remains unclear. The aims of this study were to define the mechanism of O2(*) production by uncoupled eNOS and evaluate the therapeutic potential... |
2,324,786 | The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. | Obstructive sleep apnea, characterized by intermittent periods of hypoxemia, is an independent risk factor for the development of pulmonary hypertension. However, the exact mechanisms of this disorder remain to be defined. Enhanced NADPH oxidase expression and superoxide (O2(-).) generation in the pulmonary vasculature... |
2,324,787 | Symptomatic bilateral cerebellar mass lesions: an unusual presentation of intracranial xanthogranuloma. | Xanthogranulomas are a group of benign lesions with an incidence of 1.6-7.0% in various autopsy series. Although the lateral ventricle is the most frequent intracranial site involved, most symptomatic cases occur in the choroid plexus, involving the third ventricle. Multicentric bilateral symptomatic cerebellar xanthog... |
2,324,788 | [Chronic meningococcal meningitis in an adult]. | A 46-year-old woman was admitted for a four-month history of progressive cognitive and behavioral disorders. MRI revealed hydrocephalus with meningeal enhancement after gadolinium infusion. The lumbar puncture found a purulent CSF containing 305 nucleate elements per cubic millimeter including 84% altered polymorphonuc... |
2,324,789 | Sporadic obstructive hydrocephalus in Aqp4 null mice. | Aquaporin-4 (Aqp4) is a water transport protein expressed in glia and ependymocytes in brain. We report here the unexpected occurrence of severe obstructive hydrocephalus in a random subset of Aqp4 knockout mice. Of 612 Aqp4 knockout mice produced by heterozygote-heterozygote or knockout-knockout breedings, 9.6% of off... |
2,324,790 | The influence of naturally occurring differences in birthweight on ventricular cardiomyocyte number in sheep. | In most species including man, cardiomyocytes cease proliferating soon after birth when they become terminally differentiated. A reduced complement of cardiomyocytes in infancy may adversely impact on the function and adaptive capabilities of the heart in later life. Low birthweight is associated with an increased risk... |
2,324,791 | Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation. | Taurine has been shown to prevent cardiomyocyte apoptosis. This study investigated the effects of taurine on NADPH oxidase and calpain activation in mediating apoptosis in cardiomyocytes. Apoptosis was induced by norepinephrine (NE) in cultured adult rat ventricular cardiomyocytes. NE (5 microM) increased NADPH oxidase... |
2,324,792 | An experimental in-vivo canine model for adult shunt infection. | Detailed human studies of the mechanisms and development of shunt infection in real time are not possible, and we have developed a canine hydrocephalus model to overcome this. The intention of this pilot study was to show that the canine hydrocephalus model could be shunted using conventional "human" shunts, and that a... |
2,324,793 | Persisting embryonal infundibular recess. | Persisting embryonal infundibular recess (PEIR) is a rare anomaly of the third ventricular floor that has an unclear pathogenesis. In all 7 previously described cases, PEIR was present in adult patients and was invariably associated with hydrocephalus and, in 4 reported cases, with an empty sella. These associated find... |
2,324,794 | Input impedance of distributed arterial structures as used in investigations of underlying concepts in arterial haemodynamics. | By definition, vascular impedance is described in the frequency domain as the ratio of sinusoidal functions of pressure and flow, yielding spectral values of impedance modulus and phase. The impedance spectrum is determined by the structure and physical properties of the vascular system, such that for a given system th... |
2,324,795 | Development of a quick reference table for setting programmable pressure valves in patients with idiopathic normal pressure hydrocephalus. | Quick and reliable setting of programmable pressure valves (PPVs) is important in the treatment of idiopathic normal pressure hydrocephalus (iNPH), especially for reducing overdrainage complications and related medical costs. A new quick reference table (QRT) was developed for improved PPV control and outcome. Shunt co... |
2,324,796 | Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. | Doxorubicin (DOX) is a widely used antitumor drug, but its application is limited because of its cardiotoxic side effects. Heat shock protein (Hsp)20 has been recently shown to protect cardiomyocytes against apoptosis, induced by ischemia/reperfusion injury or by prolonged beta-agonist stimulation. However, it is not c... |
2,324,797 | Glycolytic oscillations in isolated rabbit ventricular myocytes. | Previous studies have shown that glycolysis can oscillate periodically, driven by feedback loops in regulation of key glycolytic enzymes by free ADP and other metabolites. Here we show both theoretically and experimentally in cardiac myocytes that when the capacity of oxidative phosphorylation and the creatine kinase s... |
2,324,798 | Improvement of left ventricular function after modified surgical ventricular restoration: good, better, best. | The techniques of surgical reconstruction of the left ventricle after an anterior myocardial infarction have evolved toward an increasingly physiologic restoration of ventricular shape and volume, with increasing attention being paid to the multilayered structure of myocardial fibers.</AbstractText>We describe the case... |
2,324,799 | EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis. | Eph receptors have been implicated in regulating a diverse array of cellular functions in the developing nervous system. Recently, Eph receptors have been shown to promote cell death in adult germinal zones; however, their mechanisms of action remain ill-defined. In this study, we demonstrate that EphA4 is a new member... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.