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2,324,500
[Laser surgery of malignant tumors of the glottic region of the larynx].
The Nomenclature Committee of the European Laryngological Society taken the personal classification used by various members were analyzed and integrated into a common format. Thus, a new classification (Remacle et al., 2000) end next modification (Remacle et al., 2007) in was proposed and accepted by the members. This ...
2,324,501
Live monitoring of brain damage in the rat model of amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder affecting upper and lower motoneurons. The transgenic ALS rat model (hSOD-1(G93A)) was used for magnetic resonance imaging (MRI) study using a low field wide bore magnet. T2-weighted hyperintensities were observed in the brainstem, rubrospinal t...
2,324,502
X-ray exposure induces apoptosis of some proliferative epidermal cells following traumatic spinal cord injury in adult rats.
We investigated whether X-ray radiation induced apoptosis of the proliferative ependymal cells (ECs) in adult rats with spinal cord injury (SCI) and the effect of X-ray radiation on the proliferative activities of ECs. A rat model with SCI was developed and used to determine the proliferation and apoptosis of ECs in th...
2,324,503
Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance.
The fuel-sensing enzyme AMP-activated protein kinase (AMPK) has been implicated in central nervous system control of energy balance. Hypothalamic AMPK activity is increased by food deprivation, and this elevation is inhibited by refeeding or by leptin treatment. The contribution of extrahypothalamic AMPK activity in en...
2,324,504
Acute left ventricular dilatation and shock-induced myocardial dysfunction.
Whether cardiac ventricles can acutely dilate during septic myocardial dysfunction.</AbstractText>A prospective echocardiographic study was performed to assess changes of left ventricular dimensions over time in patients with septic shock.</AbstractText>A 20-bed surgical intensive care unit of Piti&#xe9;-Salp&#xea;tri&...
2,324,505
[Secondary amenorrhea and cerebral ventriculomegaly].
Cerebral ventriculomegaly and hydrocephalus are not frequently associated with endocrine disorders of the gonadotropic axis. The mechanism of this association is not clarified. The most probable cause is however a partial hypothalamic dysfunction. The examination of the few reported cases is in favour of this explanati...
2,324,506
Survival and differentiation of neuroepithelial stem cells following transplantation into the lateral ventricle of rats.
Neuroepithelial stem cells (NEPs) demonstrate a high potential for self-renewal and differentiation during embryonic development. To explore the survival and differentiation of NEPs in vivo, we isolated NEPs from green fluorescence protein (GFP) transgenic embryos and transplanted into the lateral ventricle of rats. In...
2,324,507
The effect of leptin on the tonic secretion of gonadotropins in the female rats.
This study is an attempt to determine, the in vivo action of leptin on this hypophysiotropic hypothalamic area, by evaluating the concentrations of luteinizing hormone (LH) and follicular stimulating hormone (FSH) in the serum.</AbstractText>The experiments were done by stereotaxic injection of recombinant rat leptin (...
2,324,508
Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport.
Phospholamban has been suggested to be a key regulator of cardiac sarcoplasmic reticulum (SR) Ca cycling and contractility and a potential therapeutic target in restoring the depressed Ca cycling in failing hearts. Our understanding of the function of phospholamban stems primarily from studies in genetically altered mo...
2,324,509
New experimental model of acute aqueductal blockage in cats: effects on cerebrospinal fluid pressure and the size of brain ventricles.
It is generally assumed that cerebrospinal fluid (CSF) is secreted in the brain ventricles, and so after an acute blockage of the aqueduct of Sylvius an increase in the ventricular CSF pressure and dilation of isolated ventricles may be expected. We have tested this hypothesis in cats. After blocking the aqueduct, we m...
2,324,510
Laryngeal amyloidosis causing hoarseness and airway obstruction.
Amyloidosis constitutes a fraction of 1% of benign localized laryngeal tumors and may occasionally be associated with systemic disease. A chronic, insidious, progressive, recurrent disease characterized by hoarseness, dyspnea, and stridor, it is caused by extracellular deposition of insoluble, abnormal tissue injurious...
2,324,511
[A study of the relationship between remodeling of left ventricle and endothelial injury and pro-inflammatory mediators in different stages of essential hypertension].
To explore the relationship between left ventricular remodeling and vascular endothelial injury and pro-inflammatory mediators in different stages of essential hypertension.</AbstractText>Patients were grouped in according to the duration of the disease. The control group consisted of patients with history of hypertens...
2,324,512
Interthalamic hematoma secondary to cerebrovascular atherosclerosis in an aged grizzly bear (Ursus arctos horribilis) with primary cardiac schwannoma.
A 38-year-old intact female Grizzly bear (Ursus arctos horribilis) was evaluated for progressive seizure activity, pale mucous membranes, deficient pupillary light and menace responses, and irregular shallow respiration. Because of poor response to treatment, the animal was euthanized. Gross examination revealed abunda...
2,324,513
Specific function and morphology of the right ventricle of the heart during ischemic injury of the left ventricle.
Focal ischemia of the left ventricular myocardium was modeled by surgical ligation of the descending branch of the left coronary artery at the junction of the lower and middle thirds of this artery in anesthetized rabbits. Contractility and morphological characteristics of the right ventricular myocardium were evaluate...
2,324,514
Sudden unexpected death in a female fitness athlete, with a possible connection to the use of anabolic androgenic steroids (AAS) and ephedrine.
The use of anabolic androgenic steroids (AAS) has been associated with different adverse effects, some of which potentially lethal. Most users of AAS are male, but the prevalence of such use appears to be increasing in females. Here we present a sudden unexpected death in a female fitness athlete with a possible connec...
2,324,515
Behavioral effects of systemic transforming growth factor-alpha in Syrian hamsters.
The growth factor, transforming growth factor-alpha (TGF-alpha) is strongly expressed in the hypothalamic circadian pacemaker, the suprachiasmatic nucleus (SCN). TGF-alpha is one of several SCN peptides recently suggested to function as a circadian output signal for the regulation of locomotor activity rhythms in noctu...
2,324,516
Genomic anatomy of the hippocampus.
Availability of genome-scale in situ hybridization data allows systematic analysis of genetic neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and imaging studies demonstrate functional heterogeneity along the septotemporal axis, although precise underlying circuitry and molecular subs...
2,324,517
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8.
Melanocortin 4 receptors (MC4R) are hypothesized to mediate the central nervous system actions of leptin to enhance the satiety effects of cholecystokinin (CCK). To further elucidate this mechanism, we confirmed that peripheral administration of CCK-8 is less effective in producing this effect in MC4R-deficient mice (M...
2,324,518
Morphological and histological organization of the pyriform appendage of the tetrabranchiate Nautilus pompilius (Cephalopoda, Mollusca).
The pyriform appendage, an organ only found in nautiloid cephalopods was investigated with histological, histochemical and ultrastructural methods in order to characterize the anatomical and the cytological structure of this organ. The pyriform appendage is situated within the genital septum and lies in close contact w...
2,324,519
Development of the mouse amygdala as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation.
The amygdala is located in the caudal part of the ventral telencephalon. It is composed of many subdivisions and is involved in the control of emotion. It is important to know the mechanisms of amygdalar development in order to analyze the pathogenesis of emotional disorders, but they are still not adequately understoo...
2,324,520
Tumors of the lateral ventricle: the factors that affected the preference of the surgical approach in 46 patiens.
Optimal surgical pathway for lateral ventricle tumors is still controversial. The purpose of this study is to discuss the factors that affected the preference of the surgical techniques for removing lateral ventricle tumors.</AbstractText>46 consecutive patients underwent operation for lateral ventricle tumors. The mea...
2,324,521
Minicraniotomy for endoscopic third ventriculostomy in babies: technical note with a 7-year-segment analysis.
An alternative approach to the burr hole technique for endoscopic third ventriculostomy (ETV) in babes, the minicraniotomy, is described. It is easily performed and allows to close the dura mater and restore the bone integrity. Since 2002, it is the approach to ETV in babes with open fontanel in our service.</AbstractT...
2,324,522
Hydrogen peroxide at a concentration used during neurosurgery disrupts ciliary function and causes extensive damage to the ciliated ependyma of the brain.
Hydrogen peroxide [H(2)O(2): 3% w/v (1.1 M)] has been used as a haemostatic agent during neurosurgery applied to both the external and ventricular surface of the brain. We hypothesised that H(2)O(2) would be toxic to the ciliated ependyma, a single layer of cells that separates cerebrospinal fluid from the neuronal tis...
2,324,523
Supratentorial abnormalities in the Chiari II malformation, II: tectal morphologic changes.
The sonographic diagnosis of fetal myelomeningocele has improved mainly because the diagnostic focus has shifted from observation of spinal manifestations to observation of cranial abnormalities. Intracranial diagnostic criteria rely on abnormalities in the posterior fossa. We describe abnormalities in tectal morpholog...
2,324,524
Echocardiography in the diagnosis left ventricular noncompaction.<Pagination><StartPage>64</StartPage><MedlinePgn>64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1476-7120-6-64</ELocationID><Abstract><AbstractText>Echocardiography is the method of choice to establish a diagnosis and determine...
Echocardiography is the method of choice to establish a diagnosis and determine a treatment plan for patients with noncompaction of ventricular myocardium (NVM). The 2-dimentional echocardiography, 3-dimentional echocardiography, color Doppler echocardiography and contrast-enhanced echocardiography are of critical impo...
2,324,525
Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle.
Our previous studies have shown that morphine withdrawal induced hyperactivity of cardiac noradrenergic pathways. The purpose of the present study was to evaluate the effects of morphine withdrawal on site-specific tyrosine hydroxylase (TH) phosphorylation in the rat left ventricle. Dependence on morphine was induced b...
2,324,526
Egr-1 negatively regulates calsequestrin expression and calcium dynamics in ventricular cells.
The transcription factor early growth response-1 (Egr-1) is increased in models of cardiac pathology; however, it is unclear how Egr-1 impacts the heart. We sought to identify how Egr-1 regulates expression of proteins involved in cardiomyocyte calcium homeostasis.</AbstractText>Protein expression was measured by immun...
2,324,527
Substance P expression in the distal cerebrospinal fluid-contacting neurons and spinal trigeminal nucleus in formalin-induced the orofacial inflammatory pain in rats.
The distal cerebrospinal fluid-contacting neuron (dCSF-CN) is a peculiar type of neuron whose body is in the parenchyma of the brain and processes extend into cerebrospinal fluid (CSF) in the cavity of the ventricle in the central nervous system. Because most of the dCSF-CNs are found in the dorsal raphe nucleus (DR) o...
2,324,528
Three-dimensional computational modeling of subject-specific cerebrospinal fluid flow in the subarachnoid space.
This study aims at investigating three-dimensional subject-specific cerebrospinal fluid (CSF) dynamics in the inferior cranial space, the superior spinal subarachnoid space (SAS), and the fourth cerebral ventricle using a combination of a finite-volume computational fluid dynamics (CFD) approach and magnetic resonance ...
2,324,529
[The role of structural changes of the endothelium and myocardium in the development of experimental heart failure].
The aim of the investigation was to study the role of structural myocardial and endothelial reorganization during the experimental heart failure (doxorubicin model). Rat endocardial and aortal endothelium as well as left ventricular myocardium, were studied using the methods of light and electron microscopy and immunoc...
2,324,530
Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?
Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfusi...
2,324,531
[Myocardial expression and distribution of calcineurin in normal and failing human ventricular myocardium].
To explore the expression and distribution of calcineurin (CaN) in normal and failing human myocardium.</AbstractText>Left and right ventricles were obtained from end-staged heart failure patients (n = 12) undergoing heart transplantation and donor hearts (n = 5) taken from victims of vehicle accidents. Immunohistochem...
2,324,532
[Pneumocephalus caused by neonatal Enterobacter cloacae infection in a case].
Gas-containing encephalo-meningitis is very rare. There have only been a few cases reported in the literature. The majority of neonatal cases reported in literature died. We report a case of a 5-day-old neonate who developed diffuse pneumocephalus from Enterobacter cloacae septicemia and intracranial infection.</Abstra...
2,324,533
[Effects of hypoxia-ischemia on different neural cells in subventricular zone of human fetus].
To investigate the effects of hypoxia-ischemia (HI) on different neural cells and their survival in subventricular zone (SVZ) of human fetus in mid trimester of pregnancy and thus to explore the pathogenesis of hypoxic-ischemic brain damage on the cellular level.</AbstractText>Acutely dissociated SVZ cells, prepared fr...
2,324,534
[Brain-derived neurotrophic factor and neural stem cells transplantation in treatment of hypoxic-ischemic brain injury in rats].
To investigate the effects of brain-derived neurotrophic factor (BDNF) on survival, migration and differentiation of neural stem cells (NSCs) transplanted into the brain of newborn rats with hypoxic-ischemic brain damage and the recovery of nervous functions.</AbstractText>The NSCs were separated from hippocampus of ne...
2,324,535
[Values of diffusion-weighted magnetic resonance imaging in the early detection of periventricular leukomalacia in preterm infants].
Periventricular leukomalacia (PVL), the principal form of brain injury in the premature infant, is characterized by overt focal necrotic lesions in periventricular white matter and diffuse cerebral white matter injury. The early detection of the disease is not consistently possible with cranial ultrasonography or conve...
2,324,536
The expanding family of glioneuronal tumors.
Three new entities have been recently added to the group of glioneuronal tumors in the most recent update of the World Health Organization classification of tumors of the central nervous system: papillary glioneuronal tumor, rosetted glioneuronal tumor with neuropil-like islands, and rosette-forming glioneuronal tumor ...
2,324,537
Cone-beam technique for 64-MDCT of lung: image quality comparison with stepwise (step-and-shoot) technique.
The purpose of this study was to use phantom and patient data acquired with 64-MDCT to compare the image quality and characteristics of helical high-resolution CT images obtained with cone-beam reconstruction with those of stepwise high-resolution CT images obtained with fan-beam reconstruction.</AbstractText>We recons...
2,324,538
Spectrum of choroid plexus lesions in children.
The aim of this article is to review the embryology of the choroid plexus and the spectrum of disorders involving the choroid plexus in children and to illustrate their radiologic features.</AbstractText>The choroid plexus is an important part of the CNS that can be the primary or secondary location for many congenital...
2,324,539
Relationship of gliomas to the ventricular walls.
The role of neural stem cells in gliomagenesis remains controversial. The aim of this study was to determine the anatomic relationship of human gliomas to the lining of the ventricular walls, known as the subventricular zone, an area replete with neural stem cells. We performed a retrospective radiographic analysis of ...
2,324,540
Strain-encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers: Comparison with conventional tagging.
To evaluate the ability of strain-encoded (SENC) magnetic resonance imaging (MRI) for regional systolic and diastolic strain analysis of the myocardium in healthy volunteers.</AbstractText>Circumferential and longitudinal peak systolic strain values of 75 healthy volunteers (35 women and 40 men, mean age 44 +/- 12 year...
2,324,541
Absolute blood contrast concentration and blood signal saturation on myocardial perfusion MRI: estimation from CT data.
To determine the optimal contrast injection rate and absolute blood gadolinium concentration for optimal first-pass imaging.</AbstractText>The concentration of contrast medium in left ventricle (LV) was estimated from dynamic computed tomography (CT) by administering iodinated contrast medium of volume (0.2 mL/kg) equi...
2,324,542
Cerebellar ganglioglioma.
The location of ganglioglioma (GG) within the infratentorial compartment is unusual. The authors report a rare case of GG in the cerebellar hemisphere. A 12-year-old boy suffered from headache and gait disturbance. Neuroimaging studies demonstrated a large enhancing cerebellar mass with cystic components compressing th...
2,324,543
Changes of biochemical parameters and enzyme activities in broiler chickens with cold-induced ascites.
An experiment with 250 one-day-old male broilers (Ross 308) was conducted to investigate the differences of some blood parameters of cold-induced ascitic and healthy broiler chicks in a 6-wk period. The chickens were divided into 2 groups of 5 replicates each. One group of these chickens was raised in normal temperatur...
2,324,544
In- and outpatients with noncompaction: differences in cardiac and neuromuscular co-morbidity.
The prognosis of patients with left ventricular hypertrabeculation/noncompaction (LVHT) is controversial. LVHT is associated with neuromuscular disorders (NMD) and diagnosed echocardiographically in in- as well as outpatients. We compared cardiologic and neurologic findings and mortality in LVHT-patients according to t...
2,324,545
Expression of leptin receptor by glial cells of the nucleus tractus solitarius: possible involvement in energy homeostasis.
Leptin, an adipocyte-derived hormone, regulates food intake and body weight by acting principally on the hypothalamus, which displays the highest expression of leptin receptor (Ob-R). Nevertheless, other regions of the brain express Ob-R and constitute leptin's target sites. The dorsal vagal complex (DVC), an integrati...
2,324,546
Death of hypothalamic astrocytes in poorly controlled diabetic rats is associated with nuclear translocation of apoptosis inducing factor.
Astrocytes in the hypothalamus of poorly controlled diabetic rats are reduced in number, due to increased apoptosis and decreased proliferation, and undergo morphological changes, including a decrease in projections. These changes are associated with modifications in synaptic proteins and most likely affect neuroendocr...
2,324,547
Extracellular hypotonicity induces disturbance of sodium currents in rat ventricular myocytes.
Hypotonic solution alters ion channel activity, but little attention has been paid to voltage-dependent sodium channels. The aim of this study was to investigate the effects of hypotonic solution on transient sodium currents (I(NaT)) and persistent sodium currents (I(NaP)). We also explored whether the intracellular si...
2,324,548
K(ATP) channels are involved in regulatory volume decrease in rat cardiac myocytes.
Regulatory volume decrease (RVD) is essential for the survival of animal cells. The aim of this study was to observe the RVD process in rat ventricular myocytes, and to determine if the K(ATP) channels are involved in the RVD process in these cells. By using reverse transcriptase polymerase chain reaction and Western b...
2,324,549
Ouabain-insensitive, Na(+)-stimulated ATPase of several rat tissues: activity during a 24 h period.
Rhythmic daily changes in the Na,K-ATPase activity have been previously described for rat kidney cortex, showing two peaks: at 0900 h and 2100 h, and two valleys: at 1500 h and 0100 h -0300 h. The oscillations in Na,K-ATPase activity are produced by an inhibitor, which binds the enzyme and is present in the rat blood p...
2,324,550
A rare case of vomiting: fourth ventricular B-cell lymphoma.
We document the case of a 69-year-old man presenting with 6 weeks of intractable vomiting. Magnetic Resonance Imaging showed a homogenously enhancing mass in the caudal fourth ventricle. Surgical exploration and biopsy was performed and pathological examination demonstrated a high-grade B-cell lymphoma. The lesion was ...
2,324,551
Central primitive neuroectodermal tumour with ependymal differentiation in a dog.
A central primitive neuroectodermal tumour (PNET) with ependymal differentiation was identified in an 18-month-old female Australian terrier dog that died following signs of central nervous system disease. A large space-occupying haemorrhagic mass replaced the thalamus and part of the hypothalamus of the brain. Microsc...
2,324,552
Mechanical axial flow blood pump to support cavopulmonary circulation.<Pagination><StartPage>970</StartPage><EndPage>982</EndPage><MedlinePgn>970-82</MedlinePgn></Pagination><Abstract><AbstractText>We are developing a collapsible, percutaneously inserted, axial flow blood pump to support the cavopulmonary circulation i...
We are developing a collapsible, percutaneously inserted, axial flow blood pump to support the cavopulmonary circulation in infants with a failing single ventricle physiology. An initial design of the impeller for this axial flow blood pump was performed using computational fluid dynamics analysis, including pressure-f...
2,324,553
SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes.
<AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">Somatostatin-14 (SRIF-14), a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts both positive and negative influences directly on contraction of ventricular cardiomyocytes, indicative of involvement of more than one ...
2,324,554
The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.
In mouse, the LIM-homeodomain transcription factor Islet1 (Isl1) has been shown to demarcate a separate cardiac cell population that is essential for the formation of the right ventricle and the outflow tract of the heart. Whether Isl1 plays a crucial role in the early regulatory network of transcription factors that e...
2,324,555
[MRI diagnosis and analysis of 104 cases of fetal ventriculomegaly by ultrasonography].
To evaluate the diagnostic value of MRI in the cases suspected of ventriculomegaly by prenatal ultrasonography.</AbstractText>104 patients of suspected fetal ventriculomegaly (VM) diagnosed by ultrasonography were included from the Shengjing Hospital, China Medical University from March 2006 to October 2007. All cases ...
2,324,556
Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide.
Although receptors for the pro-inflammatory cytokine interleukin-1 have long been known to be expressed in the brain, their role in fever and behavioural depression observed during the acute phase response (APR) to tissue infection remains unclear. This may in part be due to the fact that interleukin-1 in the brain is ...
2,324,557
Rhythmic expression of clock genes in the ependymal cell layer of the third ventricle of rodents is independent of melatonin signaling.
Reproductive physiology is regulated by the photoperiod in many mammals. Decoding of the photoperiod involves circadian clock mechanisms, although the molecular basis remains unclear. Recent studies have shown that the ependymal cell layer lining the infundibular recess of the third ventricle (EC) is a key structure fo...
2,324,558
Impairment of short-term memory and Korsakoff syndrome are common in AIDS patients with cytomegalovirus encephalitis.
The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV diagnosis to death before...
2,324,559
Real-time observations of intracellular Mg2+ signaling and waves in a single living ventricular myocyte cell.
Despite the important regulatory role of Mg(2+) in metabolic pathways, its underlying mechanism is not completely understood at the single-cell level. This study examined the propagation and dynamics of Mg(2+) signaling across the cell membrane by employing the real-time visualization of intracellular Mg(2+) waves in l...
2,324,560
[Three cases of small brain infarction in the lateral wall of the fourth ventricle presenting with paroxysmal positional vertigo and vomiting].
A lesion responsible for central paroxysmal positional vertigo (PPV) is often found in the dorsolateral wall of the fourth ventricle. A relatively large tumor or hemorrhage in the dorsolateral wall of the fourth ventricle usually causes central PPV, but small brain infarction has hardly been reported to cause central P...
2,324,561
Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei.
This evidence suggests that both CB1 and CB2 receptors are important in the control of balance and hearing.</AbstractText>Although the cannabinoid CB1 receptor has been identified in the brainstem vestibular and cochlear nuclei, the existence of the second cannabinoid receptor subtype, the CB2 receptor, has been more c...
2,324,562
Cisternal neurocysticercosis.
Endoscopic third-ventriculostomy followed by removal of multiple cisternal cysts was performed in a patient with hydrocephalus secondary to cisternal cysticercosis. Adjuvant pharmacological therapy with cystocidal drugs and steroids, was administered in the postoperative period.
2,324,563
Age and gender based biomechanical shape and size analysis of the pediatric brain.
Injuries caused by motor vehicle crashes (MVCs) are the leading cause of head injury and death for children in the United States. This study aims to describe the shape and size (morphologic) changes of the cerebrum, cerebellum, brainstem, and ventricles of the pediatric occupant to better predict injury and assess how ...
2,324,564
Investigation of traumatic brain injuries using the next generation of simulated injury monitor (SIMon) finite element head model.
The objective of this study was to investigate potential for traumatic brain injuries (TBI) using a newly developed, geometrically detailed, finite element head model (FEHM) within the concept of a simulated injury monitor (SIMon). The new FEHM is comprised of several parts: cerebrum, cerebellum, falx, tentorium, combi...
2,324,565
[Expression of Ref-1 in hippocampus CA1 area of rats with Alzheimer's disease].
To investigate the expression of Redox factor-1(Ref-1) in rats with Alzheimer's disease (AD).</AbstractText>AD rat model was established by a single injection of beta-amyloid peptide (Abeta25-35) into the lateral cerebral ventricle of rats. Y-shape maze task was conducted to check the ethology. At 4th, 7th and 14th day...
2,324,566
Endoscopic removal of a central neurocytoma from the posterior third ventricle.
Central neurocytoma is a rare benign tumor that most commonly arises within the ventricular system of young adults. Its occurrence in the posterior third ventricle is one of the least reported presentations. These tumors are usually treated by a combination of either biopsy or open surgical resection, often followed by...
2,324,567
Endoscopic third ventriculostomy for malfunction in previously shunted infants.
The usage of endoscopic third ventriculostomy (ETV) as an alternative to shunt revision in the management of shunt malfunction is gaining popularity.</AbstractText>We review the clinical data of 45 patients who underwent ETV because of ventriculopritoneal shunt malfunction at Hacettepe University School of Medicine Dep...
2,324,568
Tumor necrosis factor-alpha, interleukin-1beta and nitric oxide induce calcium transients in distinct populations of cells cultured from the rat area postrema.
The area postrema (AP) represents the medullary sensory circumventricular organ lacking endothelial blood-brain barrier function at the base of the 4th cerebral ventricle. Administration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) or the nitric oxide (NO) donor diethylamino-diazenolate-2-ox...
2,324,569
No differences in MR-based volumetry between 2- and 7-year-old children with autism spectrum disorder and developmental delay.
To study brain volumes in children with ASD as compared to children with a mental retardation or a language delay (developmentally delayed). In addition, to study the association of intellectual functioning on brain volumes in children with ASD or developmental delay.</AbstractText>Thirty-four children with ASD and 13 ...
2,324,570
Intranasal delivery of transforming growth factor-beta1 in mice after stroke reduces infarct volume and increases neurogenesis in the subventricular zone.
The effect of neurotrophic factors in enhancing stroke-induced neurogenesis in the adult subventricular zone (SVZ) is limited by their poor blood-brain barrier (BBB) permeability.Intranasal administration is a noninvasive and valid method for delivery of neuropeptides into the brain, to bypass the BBB. We investigated ...
2,324,571
Electrode configurations for detection of intraventricular haemorrhage in the premature neonate.
Intraventricular haemorrhage is a common cause of death in premature human infants. As preventative measures and treatments become available, a method for monitoring and detection is required. Electrical impedance tomography (EIT) is a viable monitoring method compared to modalities such as ultrasound, MRI or CT becaus...
2,324,572
Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure.
The aim of this study was to investigate whether torasemide modifies collagen cross-linking in the failing human heart. We analyzed the degree of cross-linking and the expression of the enzyme lysyl oxidase, which regulates cross-linking, in the myocardium of patients with chronic heart failure at baseline and after 8 ...
2,324,573
Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety.
A physiological role in satiety is proposed for glucagon-like peptide-1 (GLP-1), secreted by the distal intestine in response to ingested nutrients. Here we report that in rats, ip injection of the GLP-1 receptor (GLP-1-R) antagonist exendin 9-39 (Ex9) elicited hyperphagia, but only at times of day when intake is other...
2,324,574
Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats.
In rodents, the adult subventricular zone (SVZ) generates neuroblasts which migrate to the olfactory bulb (OB) and differentiate into interneurons. Recent work suggests that the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) can enhance adult SVZ neurogenesis, but the mechanism by which it acts is unknown. Here,...
2,324,575
Periventricular heterotopia, mental retardation, and epilepsy associated with 5q14.3-q15 deletion.
Periventricular heterotopia (PH) is an etiologically heterogeneous disorder characterized by nodules of neurons ectopically placed along the lateral ventricles. Most affected patients have seizures and their cognitive level varies from normal to severely impaired. At present, two genes have been identified to cause PH ...
2,324,576
Endoscopic cystoventriculostomy for treatment of paraxial arachnoid cysts.
The optimal therapy of arachnoid cysts is controversial. In symptomatic extraventricular arachnoid cysts, fenestration into the basal cisterns is the gold standard. If this is not feasible, shunt placement is frequently performed although another endoscopic option is available.</AbstractText>Between March 1997 and June...
2,324,577
[Pediatric intraventricular tumors].
Pediatric intraventricular tumors present a well circumscribed group from surgical point of view. These tumors growing in the ventricular system cause hydrocephalus in most of the cases, the presenting symptoms are the signs of raised intracranial pressure. The mass lesion may remain silent for a long period, especiall...
2,324,578
Heart status following high G exposure in rats and the effect of brief preconditioning.
Acceleration on the +Gz axis increases pressure in the cardiac chambers. Our research was designed to study whether: 1) such acceleration would impair cardiac function; and 2) a "preconditioning" exposure to +Gz would protect the heart from any such effects.</AbstractText>There were 45 male Sprague-Dawley rats that wer...
2,324,579
Ventricular non-compaction cardiomyopathy.
Non-compaction of the left ventricle is an extremely rare cardiomyopathy resulting from a defective morphogenesis of the endomyocardium. It results in an architecturally aberrant ventricular wall consisting of two layers: a compacted layer and a loose interwoven meshwork with prominent trabeculae and deep intertrabecul...
2,324,580
Gomez-Lopez-Hernandez syndrome: two new cases and review of the literature.
Gomez-Lopez-Hernandez syndrome, or cerebellotrigeminal-dermal dysplasia, is a rare neurocutaneous syndrome of trigeminal anesthesia, scalp alopecia and cerebellar anomalies. Other features include craniosynostosis, short stature, hypertelorism, down-slanting palpebral fissures, corneal opacities, mediofacial hypoplasia...
2,324,581
A late complication of CSF shunting: acquired Chiari I malformation.
Acquired Chiari I malformation developing after cerebrospinal fluid (CSF) shunting is an intriguing late complication of CSF shunt surgery and not only raises questions as to its pathogenesis but also poses many queries about the possible adverse effects on the subsequent child development as well as on the indications...
2,324,582
Cardiac-targeted expression of soluble fas attenuates doxorubicin-induced cardiotoxicity in mice.
Doxorubicin (Dox) is known to cause cardiomyopathy and congestive heart failure upon chronic administration. The mechanisms underlying these toxicities remain uncertain but have been attributed, at least in part, by induction of cardiac cell apoptosis. Fas ligation with its cognate ligand (FasL) induces apoptosis and a...
2,324,583
Evaluation of poor left ventricle: multislice computer tomography in the assessment of myocardial viability.
The evaluation of left ventricular function and viability is critical in patients with suspected or documented ischemic heart disease. Recently, cardiac multislice computed tomography (MSCT) has emerged as a powerful modality for cardiac imaging. In addition to coronary artery assessment, contrast enhanced MSCT can pro...
2,324,584
Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage.
Auditory hair cell defect is a major cause of hearing impairment, often leading to spiral ganglia neuron (SGN) degeneration. The cell loss that follows is irreversible in mammals, because inner ear hair cells (HCs) have a limited capacity to regenerate. Here, we report that in the adult brain of both rodents and humans...
2,324,585
Exophytic giant cell glioblastoma of the medulla oblongata.
Giant cell glioblastoma is a rare variant within the spectrum of glioblastoma multiforme (GBM) tumors. A giant cell glioblastoma may be associated with a better prognosis than the common type of GBM after combined treatment involving tumor resection and radiochemotherapy. A giant cell glioblastoma may occur at various ...
2,324,586
Neuroendoscopic removal of intraventricular hemorrhage combined with hydrocephalus.
The neuroendoscope is playing an increasing role in the diagnosis and treatment of several types of lesions, in particular in the ventricular system. Hydrocephalus associated with intraventricular hemorrhage (IVH) is a good indication for neuroendoscopic surgery. We describe herein our experiences with 17 cases of IVH ...
2,324,587
Neuroendoscopic trans-third ventricle approach for lesions of the ventral brainstem surface.
Due to the establishment in recent years of neuroendoscopic third ventriculostomy (ETV), it has become possible during ETV to observe the ventral brainstem surface--particularly the prepontine cistern--in a minimally invasive manner via the third ventricular base with a neuroendoscope. As an adaptation of that techniqu...
2,324,588
Use of posterior fontanelle in the ultrasound diagnosis of intraventricular/periventricular hemorrhage.
To evaluate the use of the posterior fontanelle in premature neonates (&lt; 37 weeks) with a birth weight &lt; 1,500 g in the ultrasound diagnosis of intraventricular/periventricular hemorrhage and to assess whether the use of the anterior fontanelle associated with the posterior fontanelle changes the interrater agree...
2,324,589
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain.
The neural circuits that regulate sleep and arousal as well as their integration with circadian circuits remain unclear, especially in Drosophila. This issue intersects with that of photoreception, because light is both an arousal signal in diurnal animals and an entraining signal for the circadian clock. To identify n...
2,324,590
Low extracellular K+ increases intracellular Ca2+ oscillation and injury by activating the reverse mode Na+-Ca2+ exchanger and inhibiting the Na+, K+ ATPase in rat cardiomyocytes.
The effects of low K(+) on post-ischemic reperfused heart cells are not clearly understood. Calcium overload is one of the major causes for myocardial reperfusion injury, the present study was to investigate the role of intracellular calcium oscillations in the effects of reperfusion with low K(+) on rat myocytes.</Abs...
2,324,591
In vivo magnetic resonance imaging of endogenous neuroblasts labelled with a ferumoxide-polycation complex.
Neurogenesis occurs at the subependymal zone (SEZ) of the adult brain. Neural progenitor cells give rise to neuroblasts, which migrate to the olfactory bulb (OB) via the rostral migratory stream (RMS). Development of methods capable of labelling and tracking these cells in vivo would be of great benefit to the understa...
2,324,592
Impact of very old age on the expression of cervical spinal cord cell markers in rats.
Aging is a process associated with both anatomical changes and loss of expression of some cell markers. Intermediate filaments are known to impart mechanical stability to cells and tissues. Some of them are present in different cell populations of the central nervous system. In order to explore the impact of extreme ag...
2,324,593
The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke.
Molecular mechanisms by which stroke increases neurogenesis have not been fully investigated. Using neural progenitor cells isolated from the subventricular zone (SVZ) of the adult rat subjected to focal cerebral ischemia, we investigated the Notch pathway in regulating proliferation and differentiation of adult neural...
2,324,594
Effect of intracerebroventricular infusion of leptin on the secretory activity of the GnRH/LH axis in fasted prepubertal lambs.
Leptin is believed to link metabolic status to reproductive processes. The aim of the present study was to investigate the effect of exogenous leptin on the secretory activity of GnRH/LH system in acutely undernourished prepubertal, female lambs. Merino lambs were randomly divided into four groups, two standard-fed and...
2,324,595
Intracerebroventricular infusion of neuropeptide Y modulates VIP secretion in the fasting conscious dog.
Intracerebroventricular (icv) injection of neuropeptide Y (NPY), which is a widely-distributed neurotransmitter, into the paraventricular nuclear area has been shown previously to increase secretion of insulin and glucagon from the pancreatic islets. Vasoactive intestinal polypeptide (VIP) is a 28-amino-acid peptide th...
2,324,596
A neuregulin 1 variant is associated with increased lateral ventricle volume in patients with first-episode schizophrenia.
Structural brain abnormalities are already present at early phases of psychosis and might be the consequence of neurodevelopmental deviance. Neuregulin 1 gene (NRG1) is a candidate gene for schizophrenia, and its protein has different roles in nervous system development and plasticity. A single nucleotide polymorphism ...
2,324,597
[Takotsubo cardiomyopathy: a consensus document].
Takotsubo cardiomyopathy is a syndrome characterized by acute regional systolic dysfunction of the left ventricle, frequently related to psycho-physical acute stress, and usually reversible. This rare syndrome involves more often the female sex with the highest frequency of occurrence between the seventh and eighth dec...
2,324,598
Rhombencephalosynapsis and related anomalies: a neuropathological study of 40 fetal cases.
Rhombencephalosynapsis is an uncommon cerebellar malformation defined by vermian agenesis with fusion of the hemispheres and of the dentate nuclei. Embryologic and genetic mechanisms are still unknown, and to date, no animal models are available. Ultrasound diagnosis is generally suspected after 22 weeks of gestation, ...
2,324,599
Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation.
Radiation therapy is a widely used treatment for malignant central nervous system tumors. Mature neurons are terminally differentiated, whereas stem and progenitor cells have a prominent proliferative capacity and are therefore highly vulnerable to irradiation. Our aim was to investigate how cranial radiation in young ...