Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
2,326,000 | Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning. | In Parkinson's disease (PD), neurogenesis in the subventricular zone (SVZ)-olfactory bulb (OB) axis is affected as the result of the lack of dopaminergic innervations reaching the SVZ. This aberrant network has been related to the hyposmia of PD patients, which is an early diagnostic marker of the disease. Consequently... |
2,326,001 | Acute enlargement of subdural hygroma due to subdural hemorrhage in a victim of child abuse. | An 11-month-old female baby was found dead by her mother. Cranial postmortem CT prior to the forensic autopsy showed dilatation of bilateral extra-axial spaces and ventricles. The autopsy revealed a new linear fracture of the left parietal bone and occipital bone, and a healed linear fracture of the right parietal bone... |
2,326,002 | Antecedents and correlates of visual field deficits in children born extremely preterm. | We sought to identify the antecedents and correlates of visual field deficits (VFDs) at age 2 years among infants born before the 28th week of gestation.</AbstractText>The visual fields of 1023 infants were assessed by confrontation at age 2 years. We compared the ante-and postnatal characteristics and exposures of the... |
2,326,003 | Left ventricular non-compaction cardiomyopathy associated with epidermolysis bullosa simplex with muscular dystrophy and PLEC1 mutation. | Plectin mutations have been reported in epidermolysis bullosa simplex with muscular dystrophy. We report the first case of left ventricular non-compaction in an 18-year-old male with epidermolysis bullosa simplex with muscular dystrophy. The patient was diagnosed with epidermolysis bullosa simplex after blistering was ... |
2,326,004 | Pilocytic astrocytoma presenting with atypical features on magnetic resonance imaging. | Pilocytic astrocytoma, which is classified as a grade I astrocytic tumor by the World Health Organization, is the most common type of glioma in children and young adults. Pilocytic astrocytoma generally appears as a well-circumscribed, contrast-enhancing lesion, frequently with cystic components on magnetic resonance i... |
2,326,005 | [DRESS in intensive care unit: a challenging diagnosis and treatment]. | Drug reaction with eosinophilia ans systemic symptoms (DRESS) is a severe medication-induced adverse reaction, which can threaten patient's life. Clinical symptoms and organ failures present wide variability. Furthermore, the latency period is long, so that diagnosis could be a real challenge in the intensive care unit... |
2,326,006 | Fluorocitrate induced the alterations of memory-related proteins and tau hyperphosphorylation in SD rats. | Astrocytes provide structural, metabolic and trophic supports for neurons. However, there are no direct evidences whether astrocytes involve in the regulation of synaptic proteins expression and tau phosphorylation until now. Here, we injected 1 nmol fluorocitrate (FC), which preferentially taken up by astrocytes and r... |
2,326,007 | IL-1β increases necrotic neuronal cell death in the developing rat hippocampus after status epilepticus by activating type I IL-1 receptor (IL-1RI). | Interleukin-1β (IL-1β) is associated with seizure-induced neuronal cell death in the adult brain. The contribution of IL-1β to neuronal injury induced by status epilepticus (SE) in the immature brain remains unclear. In the present study, we investigated the effects of IL-1β administration on hi... |
2,326,008 | The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats. | Poststroke depression (PSD) is the most common psychological sequel after stroke. Although the neurological mechanisms of PSD remain to be fully elucidated, numerous studies have implicated the calcitonin gene-related peptide (CGRP), a potent vasodilatory neuropeptide, as key modulator of the depression. A PSD rat mode... |
2,326,009 | Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. | Intracerebroventricular injection of oxytocin (Oxt), a neuropeptide produced in hypothalamic paraventricular (PVN) and supraoptic nuclei (SON), melanocortin-dependently suppresses feeding. However, the underlying neuronal pathway is unclear. This study aimed to determine whether Oxt regulates propiomelanocortin (POMC) ... |
2,326,010 | Intraventricular pleomorphic xanthoastrocytoma: a case report. | Pleomorphic xanthoastrocytoma (PXA), an uncommon glial neoplasm, typically affects adolescents and young adults and accounts for less than 1% of all astrocytic neoplasms. The authors present a case of PXA located entirely in the third ventricle in a 24-year-old male patient. The patient presented with a 6-month history... |
2,326,011 | Intraventricular lymphoplasmacyte-rich meningioma: a case report. | Lymphoplasmacyte-rich meningioma (LPM) is one of the rarest variants of meningioma and those LPMs that arise in the intraventricular space are even rarer. LPMs are classified as grade I (benign) tumors with a low proliferative rate and diagnosis is made through the histological identification of high numbers of inflamm... |
2,326,012 | A difficult Endoscopic Third Ventriculostomy procedure: perforation of a thick Liliequist membrane with high basilar artery location. | Endoscopic Third Ventriculostomy (ETV) is a minimally invasive and safe method used in the treatment of obstructive hydrocephalus. However, arterial bleeding episodes that arise from narrowing of the safe perforation area due to a higher location of the basilar artery (BA) may have tragic consequences. Liliequist membr... |
2,326,013 | Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models. | Several studies have shown that elevated plasma cholesterol levels (i.e. hypercholesterolemia) serve as a risk factor for late-onset Alzheimer's disease (AD). However, it remains unclear how hypercholesterolemia may contribute to the onset and progression of AD pathology. In order to determine the role of hypercholeste... |
2,326,014 | The balance between stress resilience and vulnerability is regulated by corticotropin-releasing hormone during the critical postnatal period for sensory development. | Determining whether a stressful event will lead to stress-resilience or vulnerability depends probably on an adjustable stress response set point, which is most likely effective during postnatal sensory development and involves the regulation of corticotrophin-releasing hormone (CRH) expression. During the critical per... |
2,326,015 | Neuropeptide-Y modulates eating patterns and masticatory muscle activity in rats. | Neuropeptide Y (NPY) is a powerful orexigenic peptide secreted by hypothalamic neurons. The present study investigates how NPY injection into the lateral ventricle modulates masticatory movements and eating behavior. Behavioral experiments showed that cumulative food intake over a 4-h period and latency to eating were ... |
2,326,016 | H2 and H3 relaxin inhibit high glucose-induced apoptosis in neonatal rat ventricular myocytes. | High concentrations of glucose induce cardiomyocyte apoptosis, and contribute to diabetic cardiomyopathy. Relaxin-2 and relaxin-3 are two members of the relaxin peptide family that are cardioprotective. However, it remains unknown whether relaxin-2 or relaxin-3 can regulate apoptosis in high glucose treated-neonatal ra... |
2,326,017 | Third Ventriculostomy in Late-onset Idiopathic Aqueductal Stenosis Treatment: A Focus on Clinical Presentation and Radiological Diagnosis. | Endoscopic third ventriculostomy (ETV) is considered the gold standard treatment for obstructive hydrocephalus due to partial or complete obstruction of cerebrospinal fluid (CSF) ventricular pathways caused by mass lesions. However long-term efficacy of this procedure remains controversial as treatment of chronic adult... |
2,326,018 | Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. | Rats offered 30% sucrose solution in addition to chow and water become leptin resistant therefore we investigated the effect of sucrose solution consumption on leptin signaling. In Experiment 1 rats were resistant to 3rd ventricle injections of1.5 μg leptin after 36 days of sucrose and western blot indicated that... |
2,326,019 | Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism. | We previously found that TIGAR (TP53-induced glycolysis and apoptosis regulator) was upregulated in response to ischemia/reperfusion insult in a TP53-independent manner. The present study sought to investigate the regulatory mechanisms of TIGAR upregulation in animal and cellular models of stroke. The animal and cellul... |
2,326,020 | Insulin and IGF receptor signalling in neural-stem-cell homeostasis. | Neural stem cells (NSCs) are found in two regions in the adult brain: the subgranular zone (SGZ) in the hippocampal dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. Similarly to other somatic stem cells, adult NSCs are found within specialized niches that are organized to facilitate N... |
2,326,021 | Spinal Cord Ependymal Responses to Naturally Occurring Traumatic Spinal Cord Injury in Dogs. | The spinal cord ependymal layer (SEL) is a recent focus in spinal cord injury (SCI) research because of its potential to serve as a source of endogenous neural stem cells. Dogs are an important spontaneous model of SCI; however, there is a paucity of information available in the literature regarding the canine SEL. Her... |
2,326,022 | Silibinin ameliorates LPS-induced memory deficits in experimental animals. | Neuroinflammation is considered as one of the predisposing factor in the etiology of several neurodegenerative disorders. Therefore, the objective of the present study was to evaluate the protective effect of silibinin (SIL) in the lipopolysaccharide (LPS)-induced neuroinflammatory model. The effect of SIL on memory fu... |
2,326,023 | Neurological form of Erdheim-Chester disease : Case report and review of the literature. | Report an unusual presentation of Erdheim-Chester disease revealed by a severe hypothalamic syndrome due to a hypothalamic infiltration and a review of the literature.</AbstractText>A 28-year-old man was admitted for a previous three-month history of asthenia, weight loss, and polyuria-polydipsia. Magnetic resonance im... |
2,326,024 | Extracellular hemoglobin - mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage. | Intraventricular hemorrhage (IVH) with post-hemorrhagic ventricular dilatation (PHVD) is a major cause of neurodevelopmental impairment and mortality in preterm infants. The mechanisms leading to PHVD and brain damage remain largely unknown. The choroid plexus and the ependyma, which constitute an essential part of the... |
2,326,025 | Stroke increases neural stem cells and angiogenesis in the neurogenic niche of the adult mouse. | The unique cellular and vascular architecture of the adult ventricular-subventricular zone (V/SVZ) neurogenic niche plays an important role in regulating neural stem cell function. However, the in vivo identification of neural stem cells and their relationship to blood vessels within this niche in response to stroke re... |
2,326,026 | Endoscopic excision of a lateral ventricular epidermoid-A case report of a novel technique. | Epidermoids of the lateral ventricle are relatively rare tumours. As these tumours are soft and relatively avascular, they appear to be ideally suited for endoscopic surgical excision. At present the instruments available are specifically designed for endoscopic intra ventricular surgeries, limitations being inability ... |
2,326,027 | Stereotactic radiosurgery for intraventricular brain metastases. | The authors' institution previously reported a 69% rate of crude local control for surgical management of lateral ventricle metastases at the University of Texas MD Anderson Cancer Center. For comparison, the authors here report their institutional experience with use of stereotactic radiosurgery (SRS) to treat intrave... |
2,326,028 | [Penetrating injury of the right ventricle by nail gun; report of a case]. | A 43-year-old man accidentally shot himself with a nail gun. He was seen in the other hospital. Chest computed tomography showed nail penetrating the thorax, and a small amount of pericardial effusion. He was transferred to our hospital and underwent an operation on emergency. After sternotomy and pericardiotomy, the n... |
2,326,029 | Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients. | Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the central nervous system with different pathogenesis, brain lesion patterns, and treatment strategies. However, it is still difficult to distinguish these two disease entities by neuroimaging studies. Herein, we at... |
2,326,030 | Glial tumors with neuronal differentiation. | Immunohistochemical studies for neuronal differentiation in glial tumors revealed subsets of tumors having both characteristics of glial and neuronal lineages. Glial tumors with neuronal differentiation can be observed with diverse phenotypes and histologic grades. The rosette-forming glioneuronal tumor of the fourth v... |
2,326,031 | The management of central neurocytoma: radiosurgery. | Stereotactic radiosurgery (SRS) has evolved into a mainstay in the primary and adjuvant management of most intracranial tumors. Central neurocytomas are rare, usually benign, intraventricular tumors that can be challenging to completely resect and often recur. Adjuvant therapy has been suggested for residual or recurre... |
2,326,032 | Histology and molecular aspects of central neurocytoma. | Central neurocytoma (CN) is a well-differentiated tumor of neural cells occurring within the ventricles. It is composed of monomorphic cells with round, regular nuclei within clear cytoplasm and must be distinguished from other clear cell tumors. Immunohistochemical markers of CN that aid in diagnosis include synaptoph... |
2,326,033 | Imaging of central neurocytomas. | Central neurocytoma (CN) is an important consideration in the differential diagnosis of any intraventricular lesion. Initial evaluation should include noncontrast CT, MRI with and without gadolinium contrast, and magnetic resonance (MR) spectroscopy, if available. CN classically appear as a partially calcified mass on ... |
2,326,034 | Clinical manifestations of central neurocytoma. | Central neurocytomas (CNs) are rare central nervous system tumors that occur in the lateral ventricles. They are prevalent in young adults and are typically benign with excellent prognosis following surgical resection. Because of the rarity of the disease and its similar features with more common tumors, misdiagnosis b... |
2,326,035 | An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease. | Voxel-based morphometry from conventional T1-weighted images has proved effective to quantify Alzheimer's disease (AD) related brain atrophy and to enable fairly accurate automated classification of AD patients, mild cognitive impaired patients (MCI) and elderly controls. Little is known, however, about the classificat... |
2,326,036 | Targeted disruption of the heat shock protein 20-phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy. | Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of the HSP20-phosphodiesterase 4D (PDE4D) complex results in attenuation of action p... |
2,326,037 | Early stages of the natriuretic hormone story. | The paper reviews the early stages of the research on natriuretic hormone. The described experimental work was designed and accomplished in several internationally recognized laboratories where the author was invited to extend his projects. The cross-circulation experiments in animals with acutely increased extracellul... |
2,326,038 | Functional and genetic analysis of choroid plexus development in zebrafish. | The choroid plexus, an epithelial-based structure localized in the brain ventricle, is the major component of the blood-cerebrospinal fluid barrier. The choroid plexus produces the cerebrospinal fluid and regulates the components of the cerebrospinal fluid. Abnormal choroid plexus function is associated with neurodegen... |
2,326,039 | De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair. | The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation of organotypic hippocampal slice cultures... |
2,326,040 | Cerebrospinal fluid extracellular vesicles undergo age dependent declines and contain known and novel non-coding RNAs. | Brain development requires precise orchestration of cellular events through the coordinate exchange of information between distally located cells. One mechanism by which intercellular communication is achieved is through the transfer of extracellular vesicles (EVs). Exosomes are EVs that carry lipids, nucleic acids, an... |
2,326,041 | Microalbuminuria in untreated prehypertension and hypertension without diabetes. | Hypertension (HT) and prehypertension (preHT) were independent predictors of cardiovascular diseases. Urinary albumin leakage is a manifestation of generalized vascular damage. B-type natriuretic peptide (BNP) is a vasoactive peptide secreted by left ventricle in response to myocytic stretch. We aimed to investigate re... |
2,326,042 | Structural gray matter change early in male patients with HIV. | The purpose of this study is to characterize brain gray matter volumetric changes in HIV seropositive without neurocognitive impairment and seronegative men in Asia. We investigate 36 males with HIV seropositive (mean age 34.5±9.1 years) and 33 age- and gender-matched seronegative controls (mean age 31.4±7.6 ... |
2,326,043 | [Cardiac and renal hydatid disease--contribution of imaging: report of a case]. | L’échinococcose cardiaque est rare, elle représente 0.2 à 2% des cas d'hydatidose. Elle siège essentiellement au niveau du ventricule gauche. La localisation péricardique est exceptionnelle. L’échocardiographie et la tomodensitométrie jouent un rôle primordial et so... |
2,326,044 | Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery. | Mucopolysaccharidoses (MPS) are inborn metabolic disorders caused by a deficiency of glycosaminoglycan degrading enzymes. Although intravenous enzyme replacement therapy is a viable approach for the treatment of non-neuronopathic forms of MPS, its effectiveness in the central nervous system (CNS) is limited by the bloo... |
2,326,045 | Profile of St. Jude Medical's Allure Quadra quadripolar pacemaker system for cardiac resynchronization therapy. | Congestive heart failure is a major public health epidemic and economic burden in the USA and worldwide. Cardiac resynchronization therapy is an effective therapy for treating congestive heart failure in conjunction with pharmacologic therapy. The average congestive heart failure admission costs approximately US$ 8 bil... |
2,326,046 | Anterior and posterior complexes: a step towards improving neurosonographic screening of midline and cortical anomalies. | To describe the anatomical structures that form the anterior (AC) and posterior (PC) complexes of the fetal brain and to categorize their anomalies in fetuses with cerebral abnormalities.</AbstractText>We analyzed retrospectively volume datasets from 100 normal fetuses between 20 and 30 weeks' gestation. On the axial t... |
2,326,047 | Effect of transporter inhibition on the distribution of cefadroxil in rat brain. | Cefadroxil, a cephalosporin antibiotic, is a substrate for several membrane transporters including peptide transporter 2 (PEPT2), organic anion transporters (OATs), multidrug resistance-associated proteins (MRPs), and organic anion transporting polypeptides (OATPs). These transporters are expressed at the blood-brain b... |
2,326,048 | Astrocyte development and heterogeneity. | Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to germinal niches functions as neural stem cells (NSCs) that produce various types of neuronal progeny in relation to spatiotemporal factors. A growing body of evidence supports the concept of morphological and molecular differences... |
2,326,049 | Characteristics of long non-coding RNAs in the Brown Norway rat and alterations in the Dahl salt-sensitive rat. | Long non-coding RNAs (lncRNAs) are potentially important mediators of genomic regulation. lncRNAs, however, remain poorly characterized in the rat model organism widely used in biomedical research. Using poly(A)-independent and strand-specific RNA-seq, we identified 1,500 to 1,800 lncRNAs expressed in each of the follo... |
2,326,050 | Regulation of the neural stem cell compartment by extracellular matrix constituents. | Neural stem cells (NSCs) derive from the neuroepithelium of the neural tube, develop into radial glial cells, and recede at later developmental stages. In the adult, late descendants of these embryonic NSCs reside in discretely confined areas of the central nervous system, the stem cell niches. The best accepted canoni... |
2,326,051 | Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. | Proopiomelanocortin (POMC) is a precursor gene of the neuropeptide β-endorphin in the hypothalamus and is known to regulate various physiological functions including stress response. Several recent reports showed that fetal alcohol exposure programs the hypothalamus to produce lower levels of POMC gene transcript... |
2,326,052 | Supratentorial extraventricular anaplastic ependymoma presenting with repeated intratumoral hemorrhage. | Supratentorial extraventricular anaplastic ependymomas are extremely rare. We report the case of a 23-year-old male with a supratentorial extraventricular anaplastic ependymoma that presented with repeated intratumoral hemorrhage. The patient was diagnosed with an intracerebral hematoma in the left occipital lobe and u... |
2,326,053 | Proteomics of pulmonary hypertension: could personalized profiles lead to personalized medicine? | Pulmonary hypertension (PH) is a fatal syndrome that arises from a multifactorial and complex background, is characterized by increased pulmonary vascular resistance and right heart afterload, and often leads to cor pulmonale. Over the past decades, remarkable progress has been made in reducing patient symptoms and del... |
2,326,054 | Morphometry-based measurements of the structural response to whole-brain radiation. | Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies.</AbstractText>Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect t... |
2,326,055 | The role of automatic computer-aided surgical trajectory planning in improving the expected safety of stereotactic neurosurgery.<Pagination><StartPage>1127</StartPage><EndPage>1140</EndPage><MedlinePgn>1127-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11548-014-1126-5</ELocationID><Abstra... | Investigation of the interactions between animal host and bacterial pathogen is only meaningful if the infection model employed replicates the principal features of the natural infection. This protocol describes procedures for the establishment and evaluation of systemic infection due to neuropathogenic Escherichia col... |
2,326,056 | Automated left ventricle segmentation in late gadolinium-enhanced MRI for objective myocardial scar assessment. | To develop and validate an objective and reproducible left ventricle (LV) segmentation method for late gadolinium enhanced (LGE) magnetic resonance imaging (MRI), which can facilitate accurate myocardial scar assessment.</AbstractText>A cohort of 25 ischemic patients and 25 nonischemic patients were included. A four-st... |
2,326,057 | Influence of mefloquine administration during early pregnancy on rat embryonic development. | Mefloquine (MQ) is a potent effective antimalarial drug against multiple drug-resistant Plasmodium falciparum. It has been proved that MQ can be given safely during the second and third trimesters. However, there is very limited information on the drug safety during the first trimester. The aim of the present work was ... |
2,326,058 | Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. | Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization ... |
2,326,059 | Sex-specific effects of relaxin-3 on food intake and brain expression of corticotropin-releasing factor in rats. | This study compared the effects of relaxin-3 (RLN3) on food intake, plasma corticosterone, and the expression of corticotropin-releasing factor (CRF) in male and female rats. RLN3 was injected into the lateral ventricle at 25, 200, and 800 pmol concentrations. RLN3 at 25 pmol increased food intake (grams) at 30 and 60 ... |
2,326,060 | Cardiovascular abnormalities and impaired exercise performance in adolescents with congenital adrenal hyperplasia. | PATIENTS with classic congenital adrenal hyperplasia (CAH) are treated with lifelong glucocorticoids (GCs). Cardiovascular and metabolic effects of such therapy in adolescents have never been quantified.</AbstractText>Our objective was to investigate left ventricular (LV) morphology, function, and exercise performance ... |
2,326,061 | Segmentation of ventricles in Alzheimer mr images using anisotropic diffusion filtering and level set method. | Ventricle enlargement is a useful structural biomarker for the diagnosis of Alzheimer’s Disease (AD). This devastating neurodegenerative disorder results in progression of dementia. Although AD results in the passive increment of ventricle volume, there exists a large overlap in the volume measurements of AD and n... |
2,326,062 | miR-429 inhibits migration and invasion of breast cancer cells in vitro. | Accumulating evidence indicates that microRNAs (miRNAs) are involved in regulating cancer invasion and metastasis, and an increasing number of research demonstrates that miRNAs can promote or inhibit cell motility depending on genetic background of different cancers and the microenvironment. In the present study, we es... |
2,326,063 | The influence of type 2 diabetes on left atrial remodeling. | The influence of type 2 diabetes mellitus on cardiac remodeling has been evaluated for decades; however, the majority of investigations were focused only on the left ventricle. The impact of diabetes on the left atrial (LA) function is less researched. LA enlargement has been shown as an independent predictor of cardio... |
2,326,064 | Laryngo-tracheobronchial amyloidosis: a case report and review of literature. | Amyloidosis is a spectrum of diseases characterized by abnormal extracellular accumulation of proteinaceous material; its precise etiology still remains unclear. It may affect multiple organs, of which the commonest sites are larynx, bronchus and kidney. Laryngeal amyloidosis is usually a localized phenomenon rarely as... |
2,326,065 | Systemic factors mediate reversible age-associated brain dysfunction. | Brain function declines in aging mammals. Recent work has identified dysregulation of key blood-borne factors whose altered expression during aging diminishes brain function in mice. Increased C-C motif chemokine 11 (CCL11) expression with aging is detrimental to brain function. On the other hand, plasma levels of the ... |
2,326,066 | Validating whole slide digital morphometric analysis as a microscopy tool. | Whole slide imaging (WSI) can be used to quantify multiple responses within tissue sections during histological analysis. Feature Analysis on Consecutive Tissue Sections (FACTS®) allows the investigator to perform digital morphometric analysis (DMA) within specified regions of interest (ROI) across multiple serial... |
2,326,067 | [Pregnancy and delivery in patients with an implanted shunt for hydrocephalus]. | Hydrocephalus is a disorder of abnormal accumulation of cerebrospinal fluid in the intracranial space, usually in the cerebral ventricles. The number of patients reaching reproductive age and intending to become pregnant has increased in recent years because of treatment advances. An implanted shunt is usually introduc... |
2,326,068 | Effect of chronic continual- and intermittent hypoxia-induced systemic inflammation on the cardiovascular system in rats. | Obstructive sleep apnea syndrome (OSAS) has been recognized as an important risk factor for cardiovascular morbidity and mortality. However, the underlying mechanisms are poorly understood. Present study aimed to investigate the role of NF-κB-dependent inflammation pathways in pathophysiological responses of card... |
2,326,069 | NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. | Hindbrain injection of a melanocortin-3/4 receptor agonist, MTII, reduces food intake primarily by reducing meal size. Our previously reported results indicate that N-methyl-D-aspartate-type glutamate receptors (NMDAR) in the nucleus of the solitary tract (NTS) play an important role in the control of meal size and foo... |
2,326,070 | Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice. | Mammalian SPAG6 protein is localized to the axoneme central apparatus, and it is required for normal flagella and cilia motility. Recent studies demonstrated that the protein also regulates ciliogenesis and cilia polarity in the epithelial cells of brain ventricles and trachea. Motile cilia are also present in the epit... |
2,326,071 | Quantitative analysis of somatosensory cortex development in metatherians and monotremes, with comparison to the laboratory rat. | Metatherians and monotremes are born in an immature state, followed by prolonged nurturing by maternal lactation. Quantitative analysis of isocortical sections held in the collections at the Museum für Naturkunde, Berlin was used to compare the pace of somatosensory cortex development relative to body size and pal... |
2,326,072 | Expression of glucocorticoid receptor and coactivators in ependymal cells of male rats. | Glucocorticoid receptor (GR) is a ligand-activated nuclear receptor which is widely distributed in the brain. Many types of neurons and glial cells are known to express GR, but the expression of GR in ependymal cells has yet to be identified. The present study therefore was undertaken to determine whether ependymal cel... |
2,326,073 | Role of neuronal nitric oxide synthase in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis. | Since estradiol attenuates cannabinoid-induced increases in energy intake, energy expenditure, and transmission at proopiomelanocortin (POMC) synapses in the hypothalamic arcuate nucleus (ARC), we tested the hypothesis that neuronal nitric oxide synthase (nNOS) plays an integral role. To this end, whole animal experime... |
2,326,074 | Hydrocephalus with spontaneous regression in a 14-year-old girl. | We report on a 14-year-old girl with hydrocephalus that underwent spontaneous regression without any specific treatment, such as ventriculoperitoneal shunt surgery. A 14-year-old girl was referred to our hospital with severe headache, dizziness, nausea, and vomiting. Computed tomography and FLAIR-MRI findings on admiss... |
2,326,075 | Neuropsychological outcome after endoscopic third ventriculostomy. | Cognitive dysfunction is a common complaint associated with obstructive hydrocephalus. The purpose of this study was to determine the effect of endoscopic third ventriculostomy (ETV) on the neuropsychological outcome in patients presenting with cognitive decline and obstructive hydrocephalus.</AbstractText>A retrospect... |
2,326,076 | Peroxisome proliferator-activated receptor γ inhibits pulmonary hypertension targeting store-operated calcium entry. | In this study, we investigated the role of peroxisome proliferator-activated receptor γ (PPARγ) on store-operated calcium entry (SOCE) and expression of the main store-operated calcium channel (SOCCs) components, canonical transient receptor potential (TRPC) in chronic hypoxia (CH)-induced pulmonary hyperte... |
2,326,077 | Embryonic blood-cerebrospinal fluid barrier formation and function. | During embryonic development and adult life, brain cavities and ventricles are filled with cerebrospinal fluid (CSF). CSF has attracted interest as an active signaling medium that regulates brain development, homeostasis and disease. CSF is a complex protein-rich fluid containing growth factors and signaling molecules ... |
2,326,078 | C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma. | Ependymomas are rare glial tumors of the central nervous system that arise from the cells lining the ventricles and central canal within the spinal cord. The distribution of these tumors along the neuroaxis varies by age, most commonly involving the spinal cord in adults and the posterior fossa in children. It is becom... |
2,326,079 | Takotsubo's Cardiomyopathy in a Patient with Kartagener's Syndrome. | A 46-year-old African-American male with past medical history significant for Kartagener's syndrome, essential hypertension, and HIV presented with acute chest pain. ECG and troponins indicated an acute myocardial infarction. Ventriculography confirmed dyskinesia of the left ventricle, with an EF of 25%. However the co... |
2,326,080 | The choroid plexuses and their impact on developmental neurogenesis. | During brain development the neural stem cells are regulated by both intrinsic and extrinsic sources. One site of origin of extrinsic regulation is the developing choroid plexuses, primely situated inside the cerebral ventricles. The choroid plexuses are very active in terms of both secretion and barrier function as so... |
2,326,081 | A comparative study of intraventricular central neurocytomas and extraventricular neurocytomas. | Similar histology and clinical behavior of both intraventricular central neurocytomas (CNs) and extraventricular neurocytomas (EVNs) may argue against the idea that EVNs were the distinct entity to distinguish from CNs in the 2007 World Health Organization classification. To explore respective characteristics and compa... |
2,326,082 | MRI characteristics of fourth ventricle arachnoid diverticula in five dogs. | Intracranial arachnoid diverticula (cysts) are rare accumulations of cerebrospinal fluid (CSF) within the arachnoid membrane. The purpose of this retrospective study was to describe magnetic resonance imaging (MRI) characteristics of fourth ventricle arachnoid diverticula in a group of dogs. The hospital's medical reco... |
2,326,083 | Mesenchymal stem cells can prevent alterations in behavior and neurogenesis induced by Aß25-35 administration. | Mesenchymal stem cells (MSCs) are known to enhance neurogenesis in the dentate gyrus, as well as to modulate immune cell activity and inflammation. Easily obtained and expanded from the bone marrow and other tissues, MSCs have been proposed as candidates for stem cell therapy in various neurodegenerartive diseases... |
2,326,084 | Choroid plexus in the eye: a case study. | The purpose of this report is to describe a pediatric case of total retinal detachment (RD) with secondary glaucoma in the setting of posterior coloboma with the metaplastic retinal pigment epithelium showing abrupt transition to choroid plexus tissue.</AbstractText>Retrospective case report.</AbstractText>A 3-month-ol... |
2,326,085 | Posterior cranial vault distraction osteogenesis: evolution of technique. | The rapid growth of the brain in the first few years of life drives the expansion of the cranial vault. This expansion occurs primarily at the cranial sutures; premature fusion of these results in growth restriction perpendicular to the axis of the suture. The result of this is physical deformation of the cranial and f... |
2,326,086 | Longitudinal volumetric brain changes in autism spectrum disorder ages 6-35 years. | Since the impairments associated with autism spectrum disorder (ASD) tend to persist or worsen from childhood into adulthood, it is of critical importance to examine how the brain develops over this growth epoch. We report initial findings on whole and regional longitudinal brain development in 100 male participants wi... |
2,326,087 | Downsizing of lean body mass is a key determinant of Alzheimer's disease. | Lean body mass (LBM) encompasses all metabolically active organs distributed into visceral and structural tissue compartments and collecting the bulk of N and K stores of the human body. Transthyretin (TTR) is a plasma protein mainly secreted by the liver within a trimolecular TTR-RBP-retinol complex revealing from bir... |
2,326,088 | Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain. | Brain ependymal cells, which form an epithelial layer covering the cerebral ventricles, have been shown to play a role in the regulation of cerebrospinal and interstitial fluids. The machinery underlying this, however, remains largely unknown. Here, we report the specific localization of an inwardly rectifying K(+) cha... |
2,326,089 | MRI correlates of disability progression in patients with CIS over 48 months. | Gray matter (GM) and white matter (WM) pathology has an important role in disease progression of multiple sclerosis (MS).</AbstractText>To investigate the association between the development of GM and WM pathology and clinical disease progression in patients with clinically isolated syndrome (CIS).</AbstractText>This p... |
2,326,090 | Myocardial performance index in fetal anemia. | The objective of the study was to examine the correlation between fetal myocardial performance index (MPI) and hemoglobin (Hb) levels.</AbstractText>It is a prospective study involving singleton pregnancies at risk of fetal anemia as a result of maternal anti-D alloimmune disease. Right and left ventricle (LV) MPIs wer... |
2,326,091 | The distribution of doublecortin-immunopositive cells in the brains of four afrotherian mammals: the Hottentot golden mole (Amblysomus hottentotus), the rock hyrax (Procavia capensis), the eastern rock sengi (Elephantulus myurus) and the four-toed sengi (Petrodromus tetradactylus). | Adult neurogenesis in the mammalian brain is now a widely accepted phenomenon, typically occurring in two forebrain structures: the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ). Until recently, the majority of studies have focused on laboratory rodents, and it is under debat... |
2,326,092 | Neural stem cells in the immature, but not the mature, subventricular zone respond robustly to traumatic brain injury. | Pediatric traumatic brain injury is a significant problem that affects many children each year. Progress is being made in developing neuroprotective strategies to combat these injuries. However, investigators are a long way from therapies to fully preserve injured neurons and glia. To restore neurological function, reg... |
2,326,093 | True aqueductal tumors: a unique entity. | Pure aqueductal tumors (ATs) differ from pineal region and tectal/tegmental tumors in that they are epicentered within the aqueduct. Nevertheless, these tumors are rarely described as a separate type of tumor, and are often grouped with other lesions located in the same vicinity. The present multicenter study focuses o... |
2,326,094 | Progesterone and allopregnanolone improves stroke outcome in male mice via distinct mechanisms but neither promotes neurogenesis. | Based on the outcome of a number of experimental studies, progesterone (PROG) holds promise as a new therapy for stroke. To understand more about the mechanisms involved, we administered PROG (or the major metabolite, allopregnanolone, ALLO), intra-peritoneally, for a period of 24 h after transient middle cerebral... |
2,326,095 | Neuroacanthocytosis in china: a review of published reports. | Neuroacanthocytosis (NA) syndromes are a group of rare diseases characterized by the presence of acanthocytes and neuronal multisystem pathology, including chorea-acanthocytosis (ChAc), McLeod syndrome (MLS), Huntington's disease-like 2 (HDL-2), and pantothenate kinase-associated neurodegeneration (PKAN). China has the... |
2,326,096 | The impact of surgical resection of giant supratentorial brain tumor in pediatric patients: safety and neurological outcome evaluated in 23 consecutive cases. | This study aims to evaluate the impact of gross total resection of giant supratentorial brain tumors (GSBT) on survival and neurological outcome in a consecutive single-center pediatric series.</AbstractText>Clinical data of 23 patients under 18 years of age operated with GSBT (≥5 cm in diameter) were reviewed t... |
2,326,097 | Profile of toll-like receptor mRNA expression in the choroid plexus in adult ewes. | The blood-cerebrospinal fluid barrier (BCSFB) located in the epithelial cells of the choroid plexus (CP) forms the interface between the cerebrospinal fluid (CSF) and pathogen components circulating in the blood. The CP is also implicated in the passage of peripheral immune signals and circulation of immune cells into ... |
2,326,098 | Rosette-forming glioneuronal tumor with dissemination throughout the ventricular system: a case report. | A 33-year-old female was found to have a rosette-forming glioneuronal tumor (RGNT) occurring within the fourth ventricle with multifocal extension to the third and lateral ventricles. She presented with headaches, blurred vision, nausea, and intermittent dizziness. A brain magnetic resonance imaging (MRI) scan showed h... |
2,326,099 | Fatal air embolism during endoresection of choroidal melanoma. | To describe a case of intraoperative mortality because of air embolism during resection of a choroidal melanoma by pars plana vitrectomy.</AbstractText>Retrospective interventional case report.</AbstractText>A 69-year-old man died unexpectedly at the time of pars plana vitrectomy. The operative technique involved the u... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.