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2,326,100 | Acute Shunt Malfunction Caused by Percutaneous Endoscopic Gastrostomy without Shunt Infection. | Percutaneous endoscopic gastrostomy tube placement is often performed in patients with a ventriculoperitoneal shunt and it has been accepted as a safe procedure. The authors report a case of a 50-year-old male who developed acute exacerbation of the hydrocephalus immediately after the percutaneous endoscopic gastrostom... |
2,326,101 | Late onset oral treatment with tranilast following large myocardial infarction has no beneficial effects on cardiac remodeling and mortality in rats. | Tranilast (Tra) reduces intracardiac interstitial fibrosis in the animal models of hypertensive heart failure and diabetic cardiomyopathy by inhibiting cardiac fibroblasts. The present study examined whether Tra has long-term effects on the cardiac remodeling in the remote area of the left ventricle (LV) following myoc... |
2,326,102 | Colloid cyst of the third ventricle presenting with features of Terson's syndrome. | This report describes a middle-aged man presenting to the ophthalmologist with history of seeing floaters before both eyes since 2-weeks duration. A history of intermittent headache and dizziness of recent onset was elicited on questioning. Ocular examination showed bilateral early papilloedema and mild vitreous hemorr... |
2,326,103 | Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity. | Sorafenib is associated with adverse cardiac effects, including left ventricular dysfunction. However, the precise mechanism remains unclear. Here, we aimed to establish the genes responsible for this cardiotoxicity using zebrafish and human cardiomyocytes. Fluorescent cardiac imaging using pigmentless zebrafish with g... |
2,326,104 | Regional choroidal blood flow and multifocal electroretinography in experimental glaucoma in rhesus macaques. | To test a hypothesis of regional variation in the effect of experimental glaucoma on choroidal blood flow (ChBF) and retinal function.</AbstractText>Five rhesus macaques underwent laser trabecular destruction (LTD) to induce elevated intraocular pressure (IOP). Intraocular pressures were elevated for 56 to 57 weeks. Mu... |
2,326,105 | Melatonin feedback on clock genes: a theory involving the proteasome. | The expression of 'clock' genes occurs in all tissues, but especially in the suprachiasmatic nuclei (SCN) of the hypothalamus, groups of neurons in the brain that regulate circadian rhythms. Melatonin is secreted by the pineal gland in a circadian manner as influenced by the SCN. There is also considerable evidence tha... |
2,326,106 | Thyroid Hormone-Regulated Cardiac microRNAs are Predicted to Suppress Pathological Hypertrophic Signaling. | Cardiomyocyte size in the healthy heart is in part determined by the level of circulating thyroid hormone (TH). Higher levels of TH induce ventricular hypertrophy, primarily in response to an increase in hemodynamic load. Normal cardiac function is maintained in this form of hypertrophy, whereas progressive contractile... |
2,326,107 | [Structure of the cortical cytoskeleton of the left cardiac ventricle hystiocytes and of soleus muscle fibers in rats following short-time suspension]. | Purpose of the investigation was to examine structural rearrangements in the cortical cytoskeleton as a result of changes in external mechanic conditions. Objects of the investigation were Wistar rat's m. soleus fibers and left ventricle hystiocytes. Suspension for 6, 12, 18, 24 and 72 hours was performed according to ... |
2,326,108 | Sporadic premature aging in a Japanese monkey: a primate model for progeria. | In our institute, we have recently found a child Japanese monkey who is characterized by deep wrinkles of the skin and cataract of bilateral eyes. Numbers of analyses were performed to identify symptoms representing different aspects of aging. In this monkey, the cell cycle of fibroblasts at early passage was significa... |
2,326,109 | Comparison of attenuation of striated muscle between postmortem and antemortem computed tomography: results of a longitudinal study. | We evaluated the postmortem changes of striated muscle by comparing computed tomography (CT) images obtained postmortem and antemortem in the same patients.</AbstractText>We studied 33 consecutive patients who underwent antemortem CT, postmortem CT, and pathological autopsy in our tertiary care hospital between April 2... |
2,326,110 | Respiratory inhibition after crying and feeding hypoxemia in infants. | To determine the incidence, risk factors and natural history of respiratory inhibition after crying (RIAC) and feeding hypoxemia.</AbstractText>We screened for RIAC and feeding hypoxemia among 393 infants with a gestational age ≥ 36 weeks using pulse oximetry. Twenty-seven infants were treated in the neon... |
2,326,111 | Neuroendoscopic biopsy of brain lesions: accuracy and complications. | The authors conducted a study to analyze the accuracy of neuroendoscopic biopsies of ventricular and periventricular lesions and record any difficulties or complications of the neuroendoscopic biopsy procedure.</AbstractText>A total of 50 patients with different diseases consecutively underwent endoscopic biopsy proced... |
2,326,112 | Design and evaluation of a new synthetic brain simulator for endoscopic third ventriculostomy. | Endoscopic third ventriculostomy (ETV) is an effective but technically demanding procedure with significant risk. Current simulators, including human cadavers, animal models, and virtual reality systems, are expensive, relatively inaccessible, and can lack realistic sensory feedback. The purpose of this study was to co... |
2,326,113 | Atrophy and other potential factors affecting long term deep brain stimulation response: a case series. | To describe three DBS cases which presented with new side effects or loss of benefit from stimulation after long-term follow-up and to discuss the potential contributing factors.</AbstractText>A University of Florida (UF) database (INFORM) search was performed, identifying three patients, two Parkinson's disease (PD) a... |
2,326,114 | Atlas-based quantification of cardiac remodeling due to myocardial infarction. | Myocardial infarction leads to changes in the geometry (remodeling) of the left ventricle (LV) of the heart. The degree and type of remodeling provides important diagnostic information for the therapeutic management of ischemic heart disease. In this paper, we present a novel analysis framework for characterizing remod... |
2,326,115 | Joubert syndrome: imaging features and illustration of a case. | Joubert Syndrome (JS) is a rare autosomal recessive disorder characterised clinically by neonatal breathing dysregulation, developmental delay, intellectual disability, hypotonia, ataxia, nystagmus.</AbstractText>We present another case of this uncommon syndrome in a 12 years old patient presenting with classical compl... |
2,326,116 | En bloc staining with hydroquinone treatment for block face imaging. | IntroductionBecause recent three-dimensional (3D) ultrastructural reconstruction techniques such as serial block face scanning electron microscopy (SBFSEM), obtain their images directly from the flat surface of specimens via material contrast[1], specimens should be strongly stained with heavy metals prior to resin emb... |
2,326,117 | A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces. | Experimental evidence has cast doubt on the classical model of river-like cerebrospinal fluid (CSF) flow from the choroid plexus to the arachnoid granulations. We propose a novel model of water transport through the parenchyma from the microcirculation as driven by Starling forces. This model investigates the effect of... |
2,326,118 | Evaluating indirect subthalamic nucleus targeting with validated 3-tesla magnetic resonance imaging. | <AbstractText Label="BACKGROUND/OBJECTIVES" NlmCategory="OBJECTIVE">Indirect targeting of the subthalamic nucleus (STN) is commonly utilized at deep brain stimulation (DBS) centers around the world. The superiority of either midcommissural point (MCP)-based or red nucleus (RN)-based indirect targeting remains to be est... |
2,326,119 | MRI characteristics and follow-up findings in patients with neurological complications of enterovirus 71-related hand, foot, and mouth disease. | This study aimed to investigate the magnetic resonance imaging (MRI) characteristics and clinical and MRI follow-up findings of patients with neurological complications of enterovirus 71-related hand, foot and mouth disease.</AbstractText>Data were collected from 12 patients who developed neurological complications of ... |
2,326,120 | Physiologic pineal region, choroid plexus, and dural calcifications in the first decade of life. | Calcifications of the pineal, habenula, choroid plexus, and dura are often physiologic. In the modern CT era with thin-section images and multiplanar reformats, intracranial calcifications have become more conspicuous. We aimed to discover the CT prevalence of pineal region, choroid plexus, and dural calcifications in ... |
2,326,121 | CSF Flow in the Brain in the Context of Normal Pressure Hydrocephalus. | CSF normally flows back and forth through the aqueduct during the cardiac cycle. During systole, the brain and intracranial vasculature expand and compress the lateral and third ventricles, forcing CSF craniocaudad. During diastole, they contract and flow through the aqueduct reverses. Hyperdynamic CSF flow through the... |
2,326,122 | Properly timed exposure to central ANG II prevents behavioral sensitization and changes in angiotensin receptor expression. | Previous studies show that the angiotensin type 1 receptor (AT1R) is susceptible to rapid desensitization, but that more chronic treatments that stimulate ANG II lead to sensitization of several responses. It is unclear, however, if the processes of desensitization and sensitization interact. To test for differences in... |
2,326,123 | Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes. | Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the mechanisms, we examined cardiac gene and microRNA (miRNA) expression in cardiomyocytes shortly after exposure to physi... |
2,326,124 | Ivabradine improves left ventricular function during chronic hypertension in conscious pigs. | During chronic hypertension, increases in heart rate (HR) or adrenergic stimulation are associated with maladaptive left ventricular responses as isovolumic contraction and relaxation durations failed to reduce, impeding filling. We, therefore, investigated the effects of acute selective HR reduction with ivabradine on... |
2,326,125 | Limitations in exercise and functional capacity in long-term postpneumonectomy patients.<Pagination><StartPage>56</StartPage><EndPage>64</EndPage><MedlinePgn>56-64</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/HCR.0000000000000085</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCa... | In cardiac myocytes a complex network of membrane tubules--the transverse-axial tubule system (TATS)--controls deep intracellular signaling functions. While the outer surface membrane and associated TATS membrane components appear to be continuous, there are substantial differences in lipid and protein content. In vent... |
2,326,126 | Glucocorticoids Induce Cardiac Fibrosis via Mineralocorticoid Receptor in Oxidative Stress: Contribution of Elongation Factor Eleven-Nineteen Lysine-Rich Leukemia (ELL). | Cardiac fibrosis is considered to be a crucial factor in the development of heart failure. Blockade of the mineralocorticoid receptor (MR) attenuated cardiac fibrosis and improved the prognosis of patients with chronic heart failure but the ligand for MR and the regulatory mechanism of MR pathway in the diseased heart ... |
2,326,127 | Attractive action of FGF-signaling contributes to the postnatal developing hippocampus. | During brain development neural cell migration is a crucial, well-orchestrated, process, which leads to the proper whole brain structural organization. As development proceeds, new neurons are continuously produced, and this protracted neurogenesis is maintained throughout life in specialized germinative areas inside t... |
2,326,128 | A rare case of multicystic disseminated astrocytoma with pilomyxoid characteristics in a 4-year-old child. | Pilomyxoid astrocytomas are a more aggressive variant of pilocytic astrocytoma. Over the last 14 years, there has been increasing evidence to suggest that these tumours are distinct pathological entities to pilocytic astrocytomas. Radiological features of these tumours are slowly emerging in the neuroradiological liter... |
2,326,129 | Central neurocytoma with ependymoma-like glial component. | We present the first case of central neurocytoma with a component suggesting ependymal-like differentiation as an unclassified glioneuronal tumor. The patient was a 26-year-old Japanese man with a brain tumor extending from the frontal wall of the bilateral lateral ventricles to the corpus callosum. Histologically, the... |
2,326,130 | Neisseria meningitidis elicits a pro-inflammatory response involving IκBζ in a human blood-cerebrospinal fluid barrier model. | The human-specific, Gram-negative bacterium Neisseria meningitidis (Nm) is a leading cause of bacterial meningitis worldwide. The blood-cerebrospinal fluid barrier (BCSFB), which is constituted by the epithelial cells of the choroid plexus (CP), has been suggested as one of the potential entry sites of Nm into the CSF ... |
2,326,131 | Cranial and cerebral signs in the diagnosis of spina bifida between 18 and 22 weeks of gestation: a German multicentre study. | The aim of this article is to study secondary cranial signs in fetuses with spina bifida in a precisely defined screening period between 18 + 0 and 22 + 0 weeks of gestation.</AbstractText>On the basis of retrospective analysis of 627 fetuses with spina bifida, the value of indirect c... |
2,326,132 | FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry. | Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities in the adult heart. Understanding the developmental processes controlling cardiomyocyte proliferation may thus identify new therapeutic targets to modulate the cell-cycle activity of cardiomyocytes ... |
2,326,133 | Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction. | Actin-binding protein filamin A (FLNA) regulates signal transduction important for cell locomotion, but the role of FLNA after myocardial infarction (MI) has not been explored. The main purpose of this study was to determine the impact of endothelial deletion of FLNA on post-MI remodelling of the left ventricle (LV).</... |
2,326,134 | Endoscopic fenestration at the splenial-habenular junctional area for symptomatic cavum and tumor at the foramen of Monro: case reports and anatomical review. | The splenial-habenular junctional area is an alternative site for neuroendoscopic fenestration to divert CSF flow into the quadrigeminal cistern in cases in which endoscopic third ventriculostomy is not amenable. In some patients with obstructive hydrocephalus, the splenium of the corpus callosum can be elevated from t... |
2,326,135 | Altered expression of aquaporin 1 and 5 in the choroid plexus following preterm intraventricular hemorrhage. | Intraventricular hemorrhage (IVH) with posthemorrhagic ventricular dilatation (PHVD) is a common cause of hydrocephalus in infants. Dysregulation of cerebrospinal fluid (CSF) production by the choroid plexus may contribute to the development of PHVD. The aquaporins (AQPs), transmural water transporting proteins, are be... |
2,326,136 | Pre- and postshunting magnetization transfer ratios are in accordance with neurological and behavioral changes in hydrocephalic immature rats. | Hydrocephalus is a common neurological condition in children characterized by an imbalance between the production and absorption of cerebrospinal fluid (CSF), causing abnormal fluid accumulation in the brain cavities. Shunt systems have been used to drain excess CSF and to prevent progressive ventricular enlargement. H... |
2,326,137 | Effect of nucleus accumbens shell infusions of ganaxolone or gaboxadol on ethanol consumption in mice. | Allopregnanolone (ALLO) is an endogenous neuroactive steroid thought to alter the reinforcement value of alcohol (ethanol) due to its actions as a positive modulator of the GABAA receptor (GABAAR). Extrasynaptic GABAARs may be a particularly sensitive target of ethanol and neuroactive steroids. Previous work showed tha... |
2,326,138 | The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease. | In neurodegeneration research, normalization of regional volumes by intracranial volume (ICV) is important to estimate the extent of disease-driven atrophy. There is little agreement as to whether raw volumes, volume-to-ICV fractions or regional volumes from which the ICV factor has been regressed out should be used fo... |
2,326,139 | Pretreatment diagnosis of suprasellar papillary craniopharyngioma and germ cell tumors of adult patients. | Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome.</AbstractText>We retrospectively enro... |
2,326,140 | Assessment of the relation between mean platelet volume, non-dipping blood pressure pattern, and left ventricular mass index in sustained hypertension. | Elevated mean platelet volume may reflect presence of active large platelets, which lead to fatal or non-fatal cardiovascular events. In recent studies, lack of nocturnal blood pressure fall was presented as an independent predictor of poor prognosis in essential hypertension. The relation of raised MPV with left ventr... |
2,326,141 | Meningeal carcinomatosis in a patient with Crohn's disease. | Leptomeningeal carcinomatosis, also known as carcinomatous meningitis, is defined by spreading of neoplastic cells to the meninges and ventricles, and is a form of cancer dissemination. In this case, a patient with inflammatory bowel disease had developed a neoplastic process that spread to the meninges. A 49-year-old ... |
2,326,142 | Microcephaly-chorioretinopathy syndrome, autosomal recessive form. A case report. | The autosomal recessive form of microcephaly-chorioretinopathy syndrome is a rare genetic condition that is considered to be an important differential diagnosis with congenital toxoplasmosis.</AbstractText>Our patient was a seven-year-old white boy who was initially diagnosed with congenital toxoplasmosis. However, his... |
2,326,143 | Intracerebroventricular injection of lipopolysaccharide increases gene expression of connexin32 gap junction in rat hippocampus. | Gap junctions are intercellular membrane channels that provide direct cytoplasmic continuity between adjacent cells. This communication can be affected by changes in expression of gap junctional subunits called Connexins (Cx). Changes in the expression and function of connexins are associated with number of brain neuro... |
2,326,144 | Primary gliosarcoma with long-survival: report of two cases and review of literature. | Gliosarcoma (GS) is a rare high-grade malignant tumor with poor prognosis. The survival period of GS ranges from 4 to 18.5 months. Rarely would it be over 40 months. Survival of intraventricular GS is less than 8 months.</AbstractText>There were 2 cases of primary gliosarcoma in our hospital with long-term survival aft... |
2,326,145 | Adrenalectomy is comparable with medical treatment for reduction of left ventricular mass in primary aldosteronism: meta-analysis of long-term studies. | Primary aldosteronism (PA) is associated with an increase in left ventricular (LV) mass beyond the amount needed to compensate the hypertension-related workload. Available evidence suggests effectiveness of surgical treatment of PA in decreasing LV mass, whereas data on medical treatment are controversial. We have cond... |
2,326,146 | Alcohol alters insulin-like growth factor-1-induced transforming growth factor β1 synthesis in the medial basal hypothalamus of the prepubertal female rat. | Insulin-like growth factor-1 (IGF-1) and transforming growth factor β1 (TGFβ1) are produced in hypothalamic astrocytes and facilitate luteinizing hormone-releasing hormone (LHRH) secretion. IGF-1 stimulates release by acting directly on the LHRH nerve terminals and both peptides act indirectly through speci... |
2,326,147 | Leptomeninges: a novel stem cell niche harboring ischemia-induced neural progenitors.<Pagination><StartPage>391</StartPage><EndPage>399</EndPage><MedlinePgn>391-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.14670/HH-30.391</ELocationID><Abstract><AbstractText>It is well known that neural stem cel... | It is well known that neural stem cells (NSCs) are present in many parts of the central nervous system (CNS), including the subventricular zone (SVZ) of the lateral ventricle, subgranular zone (SGZ) of the hippocampal dentate gyrus, cortex, and spinal cord. Using a mouse model of cortical infarction, we demonstrated fo... |
2,326,148 | [Effects of twirling-rotating reinforcing and reducing technique for left ventricular morphology, concentration of ET-1 and expression of type I, III collagen mRNA in spontaneous hypertensive rats]. | To explore the effect differences between twirling-rotating reinforcing and reducing technique of acupuncture on cardiac damage in spontaneous hypertensive rats (SHR).</AbstractText>Sixty male 11-week-old SHR were randomly divided into four groups: a model control group (group A), a twirling-rotating reinforcing techni... |
2,326,149 | Effect of cardiac resynchronization therapy on ventricular repolarization: a meta-analysis. | Cardiac resynchronization therapy (CRT) was thought to have a proarrhythmic effect on ventricular repolarization. But the results of previous studies were inconsistent. The aim of this study was to determine the effect of CRT on ventricular repolarization.</AbstractText>A meta-analysis of studies focused on the effect ... |
2,326,150 | Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat. | SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice die with hydrocephalus, and surviving males are sterile because of sperm motility defects. In further exploring the ciliary dysfunction in Spag6-null mice, we d... |
2,326,151 | Segmentation of the right ventricle using diffusion maps and Markov random fields. | Accurate automated segmentation of the right ventricle is difficult due in part to the large shape variation found between patients. We explore the ability of manifold learning based shape models to represent the complexity of shape variation found within an RV dataset as compared to a typical PCA based model. This is ... |
2,326,152 | Multi-atlas spectral PatchMatch: application to cardiac image segmentation. | The automatic segmentation of cardiac magnetic resonance images poses many challenges arising from the large variation between different anatomies, scanners and acquisition protocols. In this paper, we address these challenges with a global graph search method and a novel spectral embedding of the images. Firstly, we p... |
2,326,153 | Application-driven MRI: joint reconstruction and segmentation from undersampled MRI data. | Medical image segmentation has traditionally been regarded as a separate process from image acquisition and reconstruction, even though its performance directly depends on the quality and characteristics of these first stages of the imaging pipeline. Adopting an integrated acquisition-reconstruction-segmentation proces... |
2,326,154 | [Dynamic assembly of intercalated disc during postnatal development in the rat myocardium]. | The intercalated disc (ICD) complex of cardiomyocyte consists of fascia adherens, desmosomes and gap junctions which are mainly constructed by their transmembrane proteins: N-cadherin (N-cad), desmoglein-2 (DSG2) and connexin 43 (Cx43), respectively. The aim of this study was to observe the dynamic changes in colocaliz... |
2,326,155 | NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche. | Transcription factors of the nuclear factor one (NFI) family play a pivotal role in the development of the nervous system. One member, NFIX, regulates the development of the neocortex, hippocampus, and cerebellum. Postnatal Nfix(-/-) mice also display abnormalities within the subventricular zone (SVZ) lining the latera... |
2,326,156 | Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord. | Although the central nervous system is considered a comparatively static tissue with limited cell turnover, cells with stem cell properties have been isolated from most neural tissues. The spinal cord ependymal cells show neural stem cell potential in vitro and in vivo in injured spinal cord. However, very little is kn... |
2,326,157 | Placental abruption and fetal intraventricular hemorrhage after airbag deployment: a case report. | There has been very limited documentation of the adverse maternal and/or fetal consequences of airbag deployment in association with motor vehicle accidents.</AbstractText>A 20-year-old woman, gravida 1, para 0, at 31+ 4 weeks' gestation, was involved in a motor vehicle accident. The car had been hit from the passenger... |
2,326,158 | Neuregulin-1β induces mature ventricular cardiac differentiation from induced pluripotent stem cells contributing to cardiac tissue repair. | Stem cell-derived cardiomyocytes (CMs) are often electrophysiologically immature and heterogeneous, which represents a major barrier to their in vitro and in vivo application. Therefore, the purpose of this study was to examine whether Neuregulin-1β (NRG-1β) treatment could enhance in vitro generation of ma... |
2,326,159 | Magnetic resonance imaging measures of posterior cranial fossa morphology and cerebrospinal fluid physiology in Chiari malformation type I. | It has been well documented that, along with tonsillar herniation, Chiari Malformation Type I (CMI) is associated with smaller posterior cranial fossa (PCF) and altered cerebrospinal fluid (CSF) flow and tissue motion in the craniocervical junction.</AbstractText>This study assesses the relationship between PCF volumet... |
2,326,160 | Intraoperative visualization of bilateral thrombosis in the posterior inferior cerebellar artery apparent in the telovelomedullary segment. | Unilateral posterior inferior cerebellar artery (PICA) thrombosis is frequent. However, bilateral PICA thrombosis is rare. Herein we report about an intraoperative visualization of a bilateral thrombosis of the telovelomedullary segment of the PICA. A 74-year-old woman was admitted to our department on day two of a bil... |
2,326,161 | Reciprocal changes in leptin and NPY during nutritional acceleration of puberty in heifers. | Feeding a high-concentrate diet to heifers during the juvenile period, resulting in increased body weight (BW) gain and adiposity, leads to early-onset puberty. In this study, we tested the hypothesis that the increase in GnRH/LH release during nutritional acceleration of puberty is accompanied by reciprocal changes in... |
2,326,162 | Endoscopic disconnection of hypothalamic hamartomas: safety and feasibility of robot-assisted, thulium laser-based procedures. | Hypothalamic hamartomas (HH) may induce drug-resistant epilepsy (DRE), thereby requiring surgical treatment. Conventionally, treatment is aimed at removing the lesion, but a disconnection procedure has been shown to be safer and at least as effective. The thulium laser (Revolix) has been recently introduced in urologic... |
2,326,163 | A unifying theory for the multifactorial origin of cerebellar tonsillar herniation and hydrocephalus in osteopetrosis. | Osteopetrosis is a rare congenital metabolic bone disease. There are very few reports in the literature associating cerebellar tonsillar herniation (CTH) and hydrocephalus requiring neurosurgical attention. The authors present cases of osteopetrosis requiring neurosurgical intervention from their practice and offer a d... |
2,326,164 | Oral antioxidant therapy for juvenile rats with kaolin-induced hydrocephalus. | Oxidative and nitrosylative changes have been shown to occur in conjunction with the hypoxic changes and cellular/axonal damage in hydrocephalic rodent brains. We hypothesized that antioxidant therapy would improve behavioral, neurophysiological, and/or neurobiochemical outcomes in juvenile rats following induction of ... |
2,326,165 | Hydrocephalus and neurocysticercosis: cases illustrative of three distinct mechanisms. | Cysticercosis is the most frequent parasitic infection of the nervous system. Most lesions are intracranial, and spinal involvement is rare. We describe here in two cases of neurocysticercosis (NCC) in the brain and one in the spinal cord that illustrate three distinct mechanisms leading to symptomatic acute hydrocepha... |
2,326,166 | Diffusion-tensor magnetic resonance imaging for hand and foot fibers location at the corona radiata: comparison with two lesion studies. | The corticospinal tract is the motor pathway in the human brain, and corona radiata (CR) is an important location to diagnose stroke. We detected hand and foot motor fiber tracts in the CR to investigate accurate locations using diffusion-tensor imaging (DTI) and functional imaging. Ten right-handed normal volunteers p... |
2,326,167 | Endoscopic third ventriculostomy for post-inflammatory hydrocephalus in pediatric patients: is it worth a try? | Hydrocephalus is a very common disease in developing countries. Congenital aqueductal obstruction and post-inflammatory hydrocephalus come on the top of the list of causes of hydrocephalus. Till the recent introduction of cranial endoscopy and despite their frequent complications, shunts were considered as the mainstre... |
2,326,168 | Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination. | Parenchymal oligodendrocyte progenitor cells (pOPCs) are considered the principal cell type responsible for oligodendrogenesis and remyelinaton in demyelinating diseases. Recent studies have demonstrated that neural precursor cells (NPCs) from the adult subventricular zone (SVZ) can also generate new oligodendrocytes a... |
2,326,169 | Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury. | We reported previously the formation of ectopic colonies in widespread areas of the nervous system after transplantation of fetal neural stem cells (NSCs) into spinal cord transection sites. Here, we characterize the incidence, distribution, and cellular composition of the colonies. NSCs harvested from E14 spinal cords... |
2,326,170 | ConBr, a lectin from Canavalia brasiliensis seeds, modulates signaling pathways and increases BDNF expression probably via a glycosylated target. | In the central nervous system, many receptors, ion channels and neurotransmitter transporters are glycoproteins, where the glycan chains are modulator elements. Lectins are proteins, which recognize and bind carbohydrate complexes. We have previously shown that ConBr, a lectin purified from Canavalia brasiliensis seeds... |
2,326,171 | Baseline shape diffeomorphometry patterns of subcortical and ventricular structures in predicting conversion of mild cognitive impairment to Alzheimer's disease. | In this paper, we propose a novel predictor for the conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). This predictor is based on the shape diffeomorphometry patterns of subcortical and ventricular structures (left and right amygdala, hippocampus, thalamus, caudate, putamen, globus pallidus, a... |
2,326,172 | Anatomical localization of isocitrate dehydrogenase 1 mutation: a voxel-based radiographic study of 146 low-grade gliomas. | A brain tumor's location is associated with the genetic profile of its tumor precursor cells. Mutations in isocitrate dehydrogenase 1 (IDH1) are an early event in tumor development and play a critical role in gliomagenesis. This study was conducted to specify the anatomical characteristics of IDH1 mutation in low-grade... |
2,326,173 | Neurenteric cyst of the area postrema. | Neurenteric cysts are CNS lesions most frequently occurring in the spinal cord. Intracranial neurenteric cysts are rarer, typically presenting with headache, mass effect, or location-specific symptoms. The area postrema is known as the emetic center of the brain; lesions can cause nausea and vomiting. Our case, featuri... |
2,326,174 | Magnetic resonance study of the structure and function of the hippocampus and amygdala in patients with depression. | The hippocampus and amygdala exhibit structural and functional alterations in patients with depression. The objective of this study was to investigate the structural and functional relationships between these core regions.</AbstractText>Based on the severity of their condition, 60 patients and 20 healthy controls were ... |
2,326,175 | FLAIR images at 7 Tesla MRI highlight the ependyma and the outer layers of the cerebral cortex. | Fluid-attenuated inversion recovery (FLAIR) imaging is an important clinical 'work horse' for brain MRI and has proven to facilitate imaging of both intracortical lesions as well as cortical layers at 7T MRI. A prominent observation on 7T FLAIR images is a hyperintense rim at the cortical surface and around the ventric... |
2,326,176 | Estimating passive mechanical properties in a myocardial infarction using MRI and finite element simulations. | Myocardial infarction (MI) triggers a series of maladaptive events that lead to structural and functional changes in the left ventricle. It is crucial to better understand the progression of adverse remodeling, in order to develop effective treatment. In addition, being able to assess changes in vivo would be a powerfu... |
2,326,177 | A needleless liquid jet injection delivery method for cardiac gene therapy: a comparative evaluation versus standard routes of delivery reveals enhanced therapeutic retention and cardiac specific gene expression. | This study evaluates needleless liquid jet method and compares it with three common experimental methods: (1) intramuscular injection (IM), (2) left ventricular intracavitary infusion (LVIC), and (3) LV intracavitary infusion with aortic and pulmonary occlusion (LVIC-OCCL). Two protocols were executed. First (n ... |
2,326,178 | Ex vivo cardiovascular magnetic resonance measurements of right and left ventricular mass compared with direct mass measurement in excised hearts after transplantation: a first human SSFP comparison. | CMR is considered the 'gold standard' for non-invasive LV and RV mass quantitation. This information is solely based on gradient-recalled echo (GRE) sequences while contrast dependent on intrinsic T1/T2 characteristics potentially offers superior image contrast between blood and myocardium. This study aims, for the fir... |
2,326,179 | The Impact of Trans-thoracic Ultrasound on Cardiac Injuries. | To determine the impact of trans-thoracic ultrasound (TTUS) in patients with chest trauma and potential cardiac injuries and to determine the outcome of patients with cardiac injury detected on TTUS.</AbstractText>Data were obtained from the Trauma Registry for all patients presenting alive to the University Hospital o... |
2,326,180 | Mapping ventricular expansion onto cortical gray matter in older adults. | Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct r... |
2,326,181 | Disentangling normal aging from Alzheimer's disease in structural magnetic resonance images. | The morphology observed in the brains of patients affected by Alzheimer's disease (AD) is a combination of different biological processes, such as normal aging and the pathological matter loss specific to AD. The ability to differentiate between these biological factors is fundamental to reliably evaluate pathological ... |
2,326,182 | Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S. | Neural stem cells, whose major reservoir in the adult mammalian brain is the subventricular zone (SVZ), ensure neuropoiesis, a process during which many generated cells die. Removal of dead cells and debris by phagocytes is necessary for tissue homeostasis. Using confocal and electron microscopy, we demonstrate that cu... |
2,326,183 | The Netrin/RGM receptor, Neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit. | A comprehensive understanding of adult neurogenesis is essential for the development of effective strategies to enhance endogenous neurogenesis in the damaged brain. Olfactory interneurons arise throughout life from stem cells residing in the subventricular zone of the lateral ventricle. Neural precursors then migrate ... |
2,326,184 | Histomorphological spectrum and immunohistochemical characterization of hemangioblastomas: an entity of unclear histogenesis. | Hemangioblastomas (HBs) are rare WHO grade I neoplasms of uncertain histogenesis. Most are sporadic and association with von Hippel-Lindau disease (VHL) is uncommon.</AbstractText>Histomorphological and immunohistochemical evaluation of 24 cases of HBs was done.</AbstractText>Age range was 15-68 yrs (median: 30 yrs) wi... |
2,326,185 | Biomarkers in pediatric heart disease. | A biomarker is a characteristic that can be used as an indicator of a biological state. A biomarker can be a clinical observation, laboratory test or an imaging parameter. In this review, we discuss the use of biomarkers in differentiating cardiac from noncardiac disease; predicting the prognosis of patients with heart... |
2,326,186 | [Expression of the kisspeptin/kiss1r system in the hypothalamic arcuate nucleus of rats with diet-induced obesity and its influence on the hypothalamic-pituitary-testis axis]. | To explore the expressions and functions of the kisspeptin/kiss1r system and GnRH in the hypothalamic arcuate nucleus (HAN) and the influence of the kisspeptin/kiss1r system on the hypothalamic-pituitary-testis (HPT) axis in the rat models of diet-induced obesity.</AbstractText>Ninety newborn SD male rats were randomly... |
2,326,187 | [Structural changes in the germinal matrix of the brain of fetuses and neonatal infants with ventriculomegaly and congenital hydrocephalus]. | To study structural changes in the germinal matrix (GM) in 22-to-40-week fetuses with ventriculomegaly (VM) and hydrocephalus (HC).</AbstractText>The width of the ventricular groove was borne in mind while forming study groups (the brain in VM (n = 30), HC (n = 20)) and a comparison group (n = 30). To trace changes in ... |
2,326,188 | Acute growth hormone administration increases myoglobin expression and Glut4 translocation in rat cardiac muscle cells. | Oxygen (O2) and glucose are important energy sources for the heart. This study sought to investigate the effects of acute growth hormone (GH) administration on the expression of myoglobin (Mb) and Glut4 glucose transporter, two important limiting factors for O2 and glucose utilization for energy production, in cardiac ... |
2,326,189 | Hierarchical structure from motion optical flow algorithms to harvest three-dimensional features from two-dimensional neuro-endoscopic images. | Technical advances have led to an increase in the use of the endoscope in neurosurgery in recent years, particularly for intraventricular procedures and pituitary and anterior skull base surgery. Recently stereoscopic three-dimensional (3D) endoscopes have become available and may over time replace traditional two-dime... |
2,326,190 | Isolation and study of cardiac nuclei from canine myocardium and adult ventricular myocytes. | The nuclear envelope encloses the genome as well as the molecular machinery responsible for both the replication and transcription of DNA as well as the maturation of nascent RNA. Recent studies ascribe a growing number of functions to the nuclear membrane, in addition to sequestering the DNA, through receptors and the... |
2,326,191 | CNS imaging findings associated with Parry-Romberg syndrome and en coup de sabre: correlation to dermatologic and neurologic abnormalities. | Parry-Romberg syndrome (PRS) and en coup de sabre (ECS) are variants of morphea. Although numerous findings on central nervous system (CNS) imaging of PRS and ECS have been reported, the spectrum and frequency of CNS imaging findings and relation to cutaneous and neurologic abnormalities have not been fully characteriz... |
2,326,192 | Neuronal ceroid lipofuscinosis genes, CLN2, CLN3 and CLN5 are spatially and temporally co-expressed in a developing mouse brain. | Neuronal ceroid lipofuscinosis (NCL) diseases consist of a group of genetically inherited neurodegenerative disorders that share common symptoms such as seizures, psychomotor retardation, blindness, and premature death. Although gene defects behind the NCL diseases are well characterized, very little is known how these... |
2,326,193 | No evidence of persisting unrepaired nuclear DNA single strand breaks in distinct types of cells in the brain, kidney, and liver of adult mice after continuous eight-week 50 Hz magnetic field exposure with flux density of 0.1 mT or 1.0 mT. | It has been hypothesized in the literature that exposure to extremely low frequency electromagnetic fields (50 or 60 Hz) may lead to human health effects such as childhood leukemia or brain tumors. In a previous study investigating multiple types of cells from brain and kidney of the mouse (Acta Neuropathologica 2004; ... |
2,326,194 | Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb. | New subventricular zone (SVZ)-derived neuroblasts that migrate via the rostral migratory stream are continuously added to the olfactory bulb (OB) of the adult rodent brain. Anosmin-1 (A1) is an extracellular matrix protein that binds to FGF receptor 1 (FGFR1) to exert its biological effects. When mutated as in Kallmann... |
2,326,195 | The expanding family of SMARCB1(INI1)-deficient neoplasia: implications of phenotypic, biological, and molecular heterogeneity. | Since the description of atypical teratoid/rhabdoid tumors of the central nervous system and renal/extrarenal malignant rhabdoid tumors in children, the clinicopathologic spectrum of neoplasms having in common a highly variable rhabdoid cell component (0% to 100%) and consistent loss of nuclear SMARCB1 (INI1) expressio... |
2,326,196 | An unusual cardiac mass resolving with antitubercular treatment. | We present an interesting case of a 2½-year-old child with Tetrology of Fallot with a large intracardiac mass in the left ventricle presenting with fever and bilateral stroke, that resolving with antitubercular therapy alone. |
2,326,197 | Leptin receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake. | Pontine parabrachial nucleus (PBN) neurons integrate visceral, oral, and other sensory information, playing an integral role in the neural control of feeding. Current experiments probed whether lateral PBN (lPBN) leptin receptor (LepRb) signaling contributes to this function. Intra-lPBN leptin microinjection significan... |
2,326,198 | Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain. | Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 local... |
2,326,199 | Parasitoses with central nervous system involvement. | Most of the parasitoses manifest systemically, including the central nervous system (CNS). Among the most prevalent parasitoses in Central Europe (cysticercosis, toxocarosis, echinococcosis, and toxoplasmosis), cerebral involvement is well recognized and part of the clinical presentation, which cannot be neglected. CNS... |
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