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2,329,300 | Impact of severe valvular heart disease in adult congenital heart disease patients.<Pagination><StartPage>983308</StartPage><MedlinePgn>983308</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">983308</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3389/fcvm.2022.983308</ELocationID><Abstract><Abstr... | A 16-month-old girl was referred for tachycardia and upper respiratory tract infection. Echocardiographic examination revealed pericardial effusion, mild mitral regurgitation, and left ventricle systolic dysfunction. Patient was positive for Parainfluenza type 4 virus. Her laboratory tests revealed increased troponin I... |
2,329,301 | Rare adult pilocytic astrocytoma of the septum pellucidum with novel RIN2::BRAF fusion. | Pilocytic astrocytoma is mostly a pediatric tumor with the majority of patients under age 20. Although tumors can occur throughout neuraxis, most tumors are in the cerebellum and optic chiasm. Pilocytic astrocytoma in unusual locations is often associated with different genetic alterations than the classic KIAA1549::BR... |
2,329,302 | Personalization of biomechanical simulations of the left ventricle by in-vivo cardiac DTI data: Impact of fiber interpolation methods. | Simulations of cardiac electrophysiology and mechanics have been reported to be sensitive to the microstructural anisotropy of the myocardium. Consequently, a personalized representation of cardiac microstructure is a crucial component of accurate, personalized cardiac biomechanical models. <i>In-vivo</i> cardiac Diffu... |
2,329,303 | [The relationship between left ventricular artery coupling and left ventricular work and their predictive value on prognosis in septic shock].<Pagination><StartPage>3749</StartPage><EndPage>3755</EndPage><MedlinePgn>3749-3755</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3760/cma.j.cn112137-2022062... | <b>Objective:</b> To explore the relationship between left ventricular artery coupling and left ventricular work in patients with septic shock, and further clarified their predictive value for the prognosis of septic shock. <b>Methods:</b> In total, 56 patients with septic shock admitted in the Department of Critical C... |
2,329,304 | p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1. | Multiciliated ependymal cells and adult neural stem cells are components of the adult neurogenic niche, essential for brain homeostasis. These cells share a common glial cell lineage regulated by the Geminin family members Geminin and GemC1/Mcidas. Ependymal precursors require GemC1/Mcidas expression to massively ampli... |
2,329,305 | Endurance exercise under short-duration intermittent hypoxia promotes endurance performance via improving muscle metabolic properties in mice. | This study was designed to (1) investigate the effects of acute exercise under intermittent hypoxia on muscle mRNA and protein levels, and (2) clarify the mechanisms by which exercise under intermittent hypoxia improves endurance capacity. Experiment-1: Male mice were subjected to either acute endurance exercise, exerc... |
2,329,306 | A rare coronary anomaly: The single left coronary artery with coronary artery fistula draining into the right ventricular outflow tract.<Pagination><StartPage>65</StartPage><EndPage>66</EndPage><MedlinePgn>65-66</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/echo.15508</ELocationID><Abstract><A... | A previously healthy 9-year-old girl was referred to us for the evaluation of a murmur on a routine clinical examination. Routine electrocardiogram and chest x-ray were normal. The cardiac enzymes were normal. Combining ultrasound and CCTA, it was confirmed that the hemodynamics of the heart was a left-to-right shunt a... |
2,329,307 | Development of the Periventricular Nucleus as a Brain Center, Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis. | We have recently shown that the periventricular nucleus (PeVN) of adult rats is a "mixed dopaminergic (DAergic) center" containing three thousand neurons: DAergic neurons and those expressing one of the dopamine (DA)-synthesizing enzymes. This study aims to evaluate the development of the PeVN as a mixed DAergic center... |
2,329,308 | Zebrafish as an Orthotopic Tumor Model for Retinoblastoma Mimicking Routes of Human Metastasis. | Retinoblastoma (RB) is the most common eye cancer in children that has a high mortality rate when left untreated. Mouse models for retinoblastoma have been established but are time- and cost-intensive. The aim of this work was to evaluate an orthotopic transplantation model of retinoblastoma in zebrafish that also allo... |
2,329,309 | Early Coronary Artery Calcification Progression over Two Years in Breast Cancer Patients Treated with Radiation Therapy: Association with Cardiac Exposure (BACCARAT Study).<ELocationID EIdType="pii" ValidYN="Y">5724</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/cancers14235724</ELocationID><Abstract><Abst... | Background: Radiotherapy (RT) for breast cancer (BC) can induce coronary artery disease many years after RT. At an earlier stage, during the first two years after RT, we aimed to evaluate the occurrence of increased coronary artery calcium (CAC) and its association with cardiac exposure. Methods: This prospective study... |
2,329,310 | Systemic arterial pulsatility (SAPi) in advanced heart failure: a novel hemodynamic risk stratification tool.<Pagination><StartPage>1093</StartPage><EndPage>1094</EndPage><MedlinePgn>1093-1094</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00380-022-02217-6</ELocationID><Abstract><AbstractText... | Systemic arterial pulsatility index (SAPi) is a novel hemodynamic marker for ventriculo-arterial coupling (VAC), as it integrates the contractile properties of the left ventricle with the aortic impendence. SAPi can identify heart failure patients at increased risk for adverse events. Systemic pulsatility decrease... |
2,329,311 | Different profiles of lipoprotein particles associate various degrees of cardiac involvement in adolescents with morbid obesity.<Pagination><StartPage>887771</StartPage><MedlinePgn>887771</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">887771</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3389/f... | Dyslipidemia secondary to obesity is a risk factor related to cardiovascular disease events, however a pathological conventional lipid profile (CLP) is infrequently found in obese children. The objective is to evaluate the advanced lipoprotein testing (ALT) and its relationship with cardiac changes, metabolic syndrome ... |
2,329,312 | Neural precursor cells tune striatal connectivity through the release of IGFBPL1. | The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these cells exert physiological functions is still unclear. In the present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of stri... |
2,329,313 | Kisspeptin-neuron control of LH pulsatility and ovulation. | Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads to ovulation. E2 predominantly exerts its action <i>via</i> oestr... |
2,329,314 | Experimental brain infection with cysticercosis in sheep. | <AbstractText Label="OBJECTIVE." NlmCategory="UNASSIGNED">To explore the feasibility of developing a sheep model of neurocysticercosis (NCC) by intracranial infection with T. solium oncospheres.</AbstractText><AbstractText Label="MATERIALS AND METHODS." NlmCategory="UNASSIGNED">We carried out an experimental infection ... |
2,329,315 | Superior cardiometabolic and cellular adaptive responses to multiple versus single daily sessions of high-intensity interval training in Wistar rats. | This study aimed to compare in rats the cardiometabolic and cellular adaptative responses to 8 weeks of high-intensity interval training (HIIT) performed in a single (1xHIIT) or three shorter daily sessions (3xHIIT). Male Wistar rats were assigned to untrained (n = 10), 1xHIIT (n = 10),... |
2,329,316 | Comparing the findings and diagnostic sensitivity of cardiovascular magnetic resonance in biopsy confirmed acute myocarditis with infarct-like vs. heart failure presentation.<Pagination><StartPage>69</StartPage><MedlinePgn>69</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">69</ELocationID><ELocationID E... | Cardiovascular magnetic resonance (CMR) is considered the reference imaging modality in providing a non-invasive diagnosis of acute myocarditis (AM), as it allows for the detection of myocardial injury associated with AM. However, the diagnostic sensitivity and pattern of CMR findings appear to differ according to clin... |
2,329,317 | Connecting the dots: alterations in bioelectric activity at acupuncture Ting (Jing-Well) points following CV4 cranial manipulation. | The mechanisms by which osteopathic cranial manipulative medicine (OCMM) promotes health and healing have yet to be fully elucidated. One commonly utilized OCMM technique, compression of the fourth ventricle (CV4), has been theorized to balance autonomic nervous system (ANS) activity. There is growing evidence that the... |
2,329,318 | Role of cardiac mitofusins in cardiac conduction following simulated ischemia-reperfusion.<Pagination><StartPage>21049</StartPage><MedlinePgn>21049</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">21049</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-022-25625-0</ELocationID><Abstract>... | Mitochondrial dysfunction induced by acute cardiac ischemia-reperfusion (IR), may increase susceptibility to arrhythmias by perturbing energetics, oxidative stress production and calcium homeostasis. Although changes in mitochondrial morphology are known to impact on mitochondrial function, their role in cardiac arrhyt... |
2,329,319 | A finite element model of the embryonic zebrafish heart electrophysiology.<Pagination><StartPage>107281</StartPage><MedlinePgn>107281</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmpb.2022.107281</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0169-2607(22)00662-9</ELocationID><Abstrac... | In the last 30 years, a growing interest has involved the study of zebrafish thanks to its physiological characteristics similar to those of humans. The aim of the following work is to create an electrophysiological computational model of the zebrafish heart and lay the foundation for the development of an in-silico mo... |
2,329,320 | A compartmentalized mathematical model of the β<sub>1</sub>- and β<sub>2</sub>-adrenergic signaling systems in ventricular myocytes from mouse in heart failure.<Pagination><StartPage>C263</StartPage><EndPage>C291</EndPage><MedlinePgn>C263-C291</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">... | Mouse models of heart failure are extensively used to research human cardiovascular diseases. In particular, one of the most common is the mouse model of heart failure resulting from transverse aortic constriction (TAC). Despite this, there are no comprehensive compartmentalized mathematical models that describe the co... |
2,329,321 | Expansion of the mutation spectrum and phenotype of <i>USP7</i>-related neurodevelopmental disorder. | Hao-fountain syndrome (HAFOUS) is a neurodevelopmental syndrome characterized by global developmental and severe language delays, behavioral abnormalities (including autism), and mild dysmorphic impairment of intellectual development. It is a dominant genetic disease caused by USP7</i> gene (*602519) mutations on chrom... |
2,329,322 | Incidental and Clinical Significance of Slit Ventricles in Fixed Pressure Valves. | Slit ventricle syndrome (SVS) is a recognized delayed complication of cerebrospinal fluid (CSF) shunting in children. It had been linked to the use of low-pressure shunts and considered an argument for the use of programmable valves. In this study, we aim... |
2,329,323 | Sublethal exposure to Microcystis aeruginosa extracts during the yolk-sac larval stage reduces aerobic swimming speed in juvenile zebrafish.<Pagination><StartPage>1443</StartPage><EndPage>1447</EndPage><MedlinePgn>1443-1447</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10695-022-01151-8</ELoc... | This study examined whether the aerobic swimming capacity of zebrafish juveniles is affected by the exposure of the yolk-sac larvae to sublethal concentration of Microcystis aeruginosa extract (200 mg dw L<sup>-1</sup>). Critical swimming speed significantly decreased in the pre-exposed fish (9.2 ±... |
2,329,324 | External-internal cranial expansion to treat patients with craniocerebral disproportion due to post-shunt craniosynostosis: a case series. | Secondary craniosynostosis subsequent to shunting is one of the late complications of ventricular shunt placement in the early childhood. Several interventions have been used to treat high intracranial pressure associated with this condition. This study aimed to evaluate the patients' clinical symptoms and head circumf... |
2,329,325 | [Immediate, medium- and long-term outcomes of percutaneous coronary intervention with very long drug eluting stent : An observational multicentric study].<Pagination><StartPage>8</StartPage><EndPage>15</EndPage><MedlinePgn>8-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ancard.2... | Congenital heart disease (CHD) is a well-established risk factor for inferior waitlist and post-heart transplant survival in children. Differences in outcomes between CHD subgroups are understudied. The present study compared outcomes for palliated hypoplastic left heart syndrome (HLHS) patients to other non-single ven... |
2,329,326 | Difficulties interpreting concentrations in fatal cases: example of 2,5-dimethoxy-4-chloroamphetamine.<Pagination><StartPage>383</StartPage><EndPage>392</EndPage><MedlinePgn>383-392</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11419-022-00628-8</ELocationID><Abstract><AbstractText Label="PUR... | There is currently no clear consensus on screening techniques to evaluate the presence or severity of Fontan-associated liver disease (FALD). Cardiac MRI (CMR) is used routinely for post-Fontan surveillance, but CMR-derived measures that relate to the severity of FALD are not yet defined. This was a cross-sectional sin... |
2,329,327 | [Diagnosis a fetus with Coffin-Siris syndrome due to variant of SMARCA4 gene by whole exome sequencing]. | To explore the clinical phenotype and genetic basis for a fetus suspected for Coffin-Siris syndrome.</AbstractText>Chromosomal microarray analysis (CMA) and whole exome sequencing (WES) were carried out for the fetus. Candidate variant was verified by Sanger sequencing.</AbstractText>Prenatal ultrasound at 23rd gestati... |
2,329,328 | Novel de novo ZNF148 truncating variant causing autism spectrum disorder, attention deficit hyperactivity disorder, and intellectual disability. | ZNF148 gene is a Krüppel-type transcription factor that has transcriptional regulatory function. Heterozygous variant in ZNF148 gene causes an intellectual disability syndrome characterized by global developmental delay, absence, or hypoplasia of corpus callosum, wide intracerebral ventricles, and dysmorphic facia... |
2,329,329 | Loculated hydrocephalus: is neuroendoscopy effective and safe? A 90 patients' case series and literature review. | Loculated hydrocephalus is a complex condition in which different non-communicating compartments form within the ventricular system due to different etiology, mainly intraventricular hemorrhage and infection. Since the end of the twentieth century, neuroendoscopy has been explored as a therapeutic option for loculated ... |
2,329,330 | Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet-induced obese male mice.<Pagination><StartPage>R90</StartPage><EndPage>R101</EndPage><MedlinePgn>R90-R101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152/ajpregu.00274.2021</ELocationID><Abstra... | Widespread consumption of diets high in fat and fructose (Western diet, WD) has led to increased prevalence of obesity and diastolic dysfunction (DD). DD is a prominent feature of heart failure with preserved ejection fraction (HFpEF). However, the underlying mechanisms of DD are poorly understood, and treatment option... |
2,329,331 | Identifying susceptibility genes for essential hypertension by transcriptome-wide association study.<Pagination><StartPage>101387</StartPage><MedlinePgn>101387</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">101387</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrep.2022.101387</ELocatio... | Hypertension is a leading risk factor of cardiovascular disease and mortality in the population worldwide. Recently, hundreds of genomic loci were reported for hypertension by GWAS, however, the most SNPs are located in intergenic regions of genome, where a functional cause is difficult to determine. In the current stu... |
2,329,332 | Modulation of striatal glutamatergic, dopaminergic and cholinergic neurotransmission pathways concomitant with motor disturbance in rats with kaolin-induced hydrocephalus. | Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid in the cerebral ventricles and causes motor impairments. The mechanisms underlying the motor changes remain elusive. Enlargement of ventricles compresses the striatum of the basal ganglia, a group of nuclei involved in the subcortical motor ... |
2,329,333 | [Endoscopic Endonasal Surgery for Pediatric Suprasellar Tumors]. | Pediatric suprasellar tumors are difficult to treat. Their sellar-suprasellar location frequently results in compression of the adjacent critical neurovascular structures, making them a challenging surgical entity. Our surgical strategy emphasizes on radical resection of the tumor without compromising visual or cogniti... |
2,329,334 | [Original Ventriculoperitoneal Shunt for Pediatric Hydrocephalus]. | Although the use of newly developed procedures such as endoscopic third ventriculostomy or coagulation of the choroid plexus has gradually expanded, ventriculoperitoneal(VP)shunts are still not obsolete. They are the most commonly performed surgery for treating pediatric hydrocephalus. Young neurosurgeons may frequentl... |
2,329,335 | The Effects of Cuprizone on Murine Subventricular Zone-Derived Neural Stem Cells and Progenitor Cells Grown as Neurospheres. | Despite the extensive use of the cuprizone (CPZ) demyelination animal model, there is little evidence regarding the effects of CPZ on a cellular level. Initial studies have suggested that oligodendrocytes (OL) are the main cell targets for CPZ toxicity. However, recent data have revealed additional effects on neural st... |
2,329,336 | Giant intracardiac medullary thyroid cancer metastasis.<Pagination><StartPage>5455</StartPage><EndPage>5456</EndPage><MedlinePgn>5455-5456</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/jocs.17162</ELocationID><Abstract><AbstractText>We report an unusual case of giant intracardiac medullary thy... | We report an unusual case of giant intracardiac medullary thyroid cancer metastasis. A 76-year-old woman with a 9-year history of medullary thyroid cancer presented an unexpected 7.5 cm mass in the right ventricle. Complete resection and tricuspid valve replacement led to 40 months survival.<CopyrightInformation... |
2,329,337 | Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain. | There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first time, untargeted metabolomics were employed to ascertain the perturbations of brain metabolism in th... |
2,329,338 | Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease. | Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different body compartments and their use as a biomarker in AD remains elusive. Here, we perform multiple state-of-the-art analyses to phenotypically and metabolically ... |
2,329,339 | [Evaluation of left ventricular function with left atrio-ventricular longitudinal strain in patients with lymphoma underwent anthracycline therapy].<Pagination><StartPage>1064</StartPage><EndPage>1068</EndPage><MedlinePgn>1064-1068</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3760/cma.j.cn112148-2... | <b>Objective:</b> To analyze the value of 3-dimensional speckle tracking echocardiograghy (3D-STE) derived strain parameters on the detection of subclinical myocardial deformation alterations in patients with lymphoma treated with anthracycline agents. <b>Methods:</b> This study was a retrospective study. A total of 37... |
2,329,340 | Decline of stress resilience in aging rats: Focus on choroid plexus-cerebrospinal fluid-hippocampus. | This study was designed to examine the mechanisms underlying decline of stress resilience in aged rats from the perspective of CP-CSF-hippocampus.</AbstractText>Male Wistar rats (7-8 weeks old or 20 months old) were subjected to chronic unpredictable mild stress (CUMS) for 6 weeks. The behavioral tests were conducted t... |
2,329,341 | [The effects of vagus nerve stimulation on hippocampal neuro-inflammatory and α7nAChR expression in rats with intractable epilepsy]. | <b>Objective:</b> To investigate the effects of vagus nerve stimulation(VNS) on hippocampal neuro-inflammatory and α7 nicotinic acetylcholine receptor (α7nAChR) expression in rats with intractable epilepsy (IE). <b>Methods:</b> Eighty adult male SD rats (SPF) were randomly divided into control group, model ... |
2,329,342 | Coordination of Cilia Movements in Multi-Ciliated Cells. | Multiple motile cilia are formed at the apical surface of multi-ciliated cells in the epithelium of the oviduct or the fallopian tube, the trachea, and the ventricle of the brain. Those cilia beat unidirectionally along the tissue axis, and this provides a driving force for directed movements of ovulated oocytes, mucus... |
2,329,343 | Inflammation of the cardiac coronary artery in ICR mice. | Inflammation of the cardiac coronary artery in ICR mice is occasionally observed in toxicity studies; however, this has not been well explored histologically. Herein, we investigated the detailed histology of the associated lesions in 6-8-week-old ICR mice. Coronary artery inflammation in the right ventricular wall was... |
2,329,344 | The predictive value of changes in left atrial volume index for rehospitalization in heart failure with preserved ejection fraction.<Pagination><StartPage>151</StartPage><EndPage>158</EndPage><MedlinePgn>151-158</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/clc.23952</ELocationID><Abstract><Ab... | Digoxin is used in children with heart failure and tachyarrhythmia. Its use in patients with single ventricle anatomy has increased following evidence of improved interstage survival after the Norwood procedure. Digoxin has a narrow therapeutic window and may alter serum potassium balance, inducing arrhythmias. We hypo... |
2,329,345 | Refractory psychiatric symptoms and seizure associated with Dandy-Walker syndrome: A case report and literature review. | Dandy-Walker syndrome (DWS) is a group of brain malformations which occasionally accompanied by psychotic symptoms. The co-occurrence of DWS and epilepsy in children is quite rare.</AbstractText>We reported a 14-year-old male who presented with a 8-month history of inconsistent upper limb tremor and accidental seizure.... |
2,329,346 | Von Hippel-Lindau syndrome with a rare complication of dilated cardiomyopathy: a case report.<Pagination><StartPage>489</StartPage><MedlinePgn>489</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">489</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12872-022-02913-1</ELocationID><Abstract><Ab... | Cardiomegaly means enlargement of the heart. The definition is when the transverse diameter of the cardiac silhouette is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography. It should not ... |
2,329,347 | Complete intraventricular migration of ventriculo-peritoneal shunt: A rare case report. | A ventriculoperitoneal (VP) shunt is a cerebral shunt used to treat hydrocephalus. This is used to remove the excessive accumulation of cerebrospinal fluid inside the ventricles.</AbstractText>We are reporting a rare case of complete intracranial migration of a ventriculoperitoneal shunt, a potentially fatal complicati... |
2,329,348 | Cell proliferation and neurogenesis in the adult telencephalon of the newt Cynops pyrrhogaster. | Urodele amphibians have the ability to regenerate several organs, including the brain. For this reason, the research on neurogenesis in these species after ablation of some parts of the brain has markedly progressed. However, detailed information on the characteristics and fate of proliferated cells as well as the func... |
2,329,349 | Interleukin-17 Promotes the Infiltration of CD8+ T Cells into the Brain in a Mouse Model for Alzheimer's Disease. | Interleukin-17 (IL-17) family cytokines play critical roles in inflammation and pathogen resistance. Inflammation in the central nervous system, denoted as neuroinflammation, promotes the onset and progression of Alzheimer's disease (AD). Previous studies showed that IL-17A neutralizing antibody treatment alleviated Am... |
2,329,350 | Cardio-sarcopenia: A syndrome of concern in aging. | Cardiac alterations in structure and function, namely, the left ventricle, have been intensely studied for decades, in association with aging. In recent times, there has been keen interest in describing myocardial changes that accompany skeletal muscle changes in older adults. Initially described as a cardio-sarcopenia... |
2,329,351 | Stereology of gonadotropin-releasing hormone and kisspeptin neurons in PACAP gene-deficient female mice. | The hypothalamic gonadotropin-releasing hormone (GnRH)-kisspeptin neuronal network regulates fertility in all mammals. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide isolated from the hypothalamus that is involved in the regulation of several releasing hormones and trop hormones. It is wel... |
2,329,352 | Case report and literature review: Resection of retroinfundibular craniopharyngioma via endoscopic far-lateral supracerebellar infratentorial approach. | The management of retroinfundibular craniopharyngioma (CP) remains the ultimate challenge for both transsphenoidal and open transcranial surgery because of their anatomical location and proximity to vital neurovascular structures. In this report, we aim to describe the technique and feasibility of a novel approach, the... |
2,329,353 | Right heart failure in left heart disease: imaging, functional, and biochemical aspects of right ventricular dysfunction.<Pagination><StartPage>1009</StartPage><EndPage>1022</EndPage><MedlinePgn>1009-1022</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10741-022-10276-0</ELocationID><Abstract><... | For decades, cardiologists have largely underestimated the role of the right heart in heart failure due to left heart disease. Nowadays, the importance of evaluating right ventricular (RV) structure and function in left heart failure is well documented and this concept has been emphasized in the most recent heart failu... |
2,329,354 | Solitary intraventricular tumors in dogs and cats treated with radiotherapy alone or combined with ventriculoperitoneal shunts: A retrospective descriptive case series. | Intraventricular tumors are rare, optimal treatment is not defined. Symptomatic patients often exhibit life-threatening hydrocephalus. With several months time-to-effect after radiotherapy (RT), increased intracranial pressure is concerning. This increase in pressure can be overcome by ventriculoperitoneal shunting (VP... |
2,329,355 | Management of pseudomeningocele following posterior fossa tumor surgery with absence of hydrocephalus: A case report.<Pagination><StartPage>107552</StartPage><MedlinePgn>107552</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">107552</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijscr.2022... | Tricuspid regurgitation is comparatively a common anomaly. Structural modifications of any or all of the tricuspid valve apparatus may cause the development of tricuspid regurgitation. <b>Anatomy</b> The right atrioventricular valve apparatus, or tricuspid valve, consists of the following components: 1. Three valv... |
2,329,356 | InsP<sub>3</sub>R-RyR Ca<sup>2+</sup> channel crosstalk facilitates arrhythmias in the failing human ventricle.<Pagination><StartPage>60</StartPage><MedlinePgn>60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00395-022-00967-y</ELocationID><Abstract><AbstractText>Dysregulated intracellular Ca... | Dysregulated intracellular Ca<sup>2+</sup> handling involving altered Ca<sup>2+</sup> release from intracellular stores via RyR channels underlies both arrhythmias and reduced function in heart failure (HF). Mechanisms linking RyR dysregulation and disease are not fully established. Studies in animals support a role fo... |
2,329,357 | Analysis of a cell niche with proliferative potential at the roof of the aqueduct of Sylvius. | The aqueduct of Sylvius connects the third with the fourth ventricle and is surrounded by the Periaqueductal Grey. Here, we report a novel niche of cells in the dorsal section of the aqueduct, hereby named dorsal aqueduct niche or DAN, by applying a battery of selective markers and transgenic mouse lines. The somata of... |
2,329,358 | Mitral Valve Re-Repair Due to Chordal Pseudo-Elongation Through Repeated Right Anterior Minithoracotomy.<Pagination><StartPage>548</StartPage><EndPage>552</EndPage><MedlinePgn>548-552</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/15569845221130038</ELocationID><Abstract><AbstractText Label="OB... | We aim to show the step-by-step surgical technique of mitral valve re-repair by means of a repeated right anterior minithoracotomy in a case of a procedure-related early mitral valve repair failure due to left ventricular positive remodeling and chordal pseudo-elongation.</AbstractText>The patient was readdressed to ou... |
2,329,359 | Fetal cerebral ventriculomegaly: What do we tell the prospective parents? | Fetal cerebral ventriculomegaly is a relatively common finding, observed during approximately 1% of obstetric ultrasounds. In the second and third trimester, mild (≥10 mm) and severe ventriculomegaly (≥15 mm) are defined according to the measurement of distal lateral ventricles that is included ... |
2,329,360 | Disruption of the anterior commissure in Olig2 deficient mice. | In the present study, we examined neural circuit formation in the forebrain of the Olig2 knockout (Olig2-KO) mouse model and found disruption of the anterior commissure at the late foetal stage. Axon bundles of the anterior commissure encountered the wall of the third ventricle and ceased axonal extension. L1-CAM immun... |
2,329,361 | Unusual Localization of <i>Hysterothylacium incurvum</i> in <i>Xiphias gladius</i> (Linnaeus 1758) Caught in the Atlantic Ocean. | This study represents the first report of <i>Hysterothylacium incurvum</i> within swordfish (<i>Xiphias gladius</i>) heart chambers. Swordfish is a large pelagic teleost, considered one of the most appreciated fish worldwide. Among swordfish parasites, <i>Anisakis</i> sp. and <i>Hysterothylacium</i> sp. have been used ... |
2,329,362 | Improved Locomotor Recovery in a Rat Model of Spinal Cord Injury by BioLuminescent-OptoGenetic (BL-OG) Stimulation with an Enhanced Luminopsin. | Irrespective of the many strategies focused on dealing with spinal cord injury (SCI), there is still no way to restore motor function efficiently or an adequate regenerative therapy. One promising method that could potentially prove highly beneficial for rehabilitation in patients is to re-engage specific neuronal popu... |
2,329,363 | Multiple Machine Learning Approaches for Morphometric Parameters in Prediction of Hydrocephalus. | The diagnosis of hydrocephalus is mainly based on imaging findings. However, the significance of many imaging indicators may change, especially in some degenerative diseases, and even lead to misdiagnosis.</AbstractText>This study explored the effectiveness of commonly used morphological parameters and typical radiogra... |
2,329,364 | The Ipsilateral Interhemispheric Transprecuneal Approach to the Atrium: Technical Considerations and Clinical Outcome on a Series of 7 Patients. | Surgical removal of tumors of the atrium is challenging due to their deep location, vascularization, and to their complex three-dimensional relationships with the highly functional white matter fibers of the region. To assess the feasibility and the effectiveness of the ipsilateral interhemispheric transprecuneus appro... |
2,329,365 | Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism. | Dopaminergic neuron degeneration is a hallmark of Parkinson's disease (PD). We previously reported that the inactivation of von Hippel‒Lindau (VHL) alleviated dopaminergic neuron degeneration in a C. elegans model. In this study, we investigated the specific effects of VHL loss and the underlying mechanisms in m... |
2,329,366 | Application of AP-MALDI Imaging Mass Microscope for the Rapid Mapping of Imipramine, Chloroquine, and Their Metabolites in the Kidney and Brain of Wild-Type Mice. | Mass spectrometry imaging (MSI) is well-known for the non-labeling visualization of analytes, including drugs and their metabolites in biological samples. In this study, we applied three different tools of MSI, desorption electrospray ionization (DESI)-MSI, matrix-assisted laser desorption ionization (MALDI)-MSI, and a... |
2,329,367 | Molecular and Functional Characterization of a Novel Kunitz-Type Toxin-like Peptide in the Giant Triton Snail <i>Charonia tritonis</i>. | It has been reported that the giant triton snail (<i>Charonia tritonis</i>) inserts its large proboscis and then injects venom or acid saliva from its salivary gland into its prey, the crown-of-thorns starfish <i>Acanthaster planci</i> (COTS), paralyzing it. A full-length cDNA sequence of the <i>C. tritonis</i> Ct-kuni... |
2,329,368 | The Nematic Chiral Liquid Crystal Structure of the Cardiac Myoarchitecture: Disclinations and Topological Singularities. | This is our second article devoted to the cardiac myoarchitecture considered as a nematic chiral liquid crystal (NCLC). While the first article focused on the myoarchitecture of the left ventricle (LV), this new article extends to the whole ventricular mass and introduces the concept of disclinations and topological si... |
2,329,369 | From Macro to Micro: Comparison of Imaging Techniques to Detect Vascular Network Formation in Left Ventricle Decellularized Extracellular Matrix Hydrogels. | <b>Background:</b> Angiogenesis is a crucial process in physiological maintenance and tissue regeneration. To understand the contribution of angiogenesis, it is essential to replicate this process in an environment that reproduces the biochemical and physical properties which are largely governed by the extracellular m... |
2,329,370 | Isolated Fetal Ventriculomegaly- Postnatal Outcomes and Proposed New Prognostication Classification. | Outcome of Isolated ventriculomegaly diagnosed antenatally depends on size of ventricles and associated malformations. There is scarcity of literature on the guidelines for prognostication based on outcomes as per the ventricle size.</AbstractText>The aim of this work was to study outcome of antenatally detected isolat... |
2,329,371 | BAM! Pathogen control at the brain border. | Border-associated macrophages (BAMs) reside at the interface between the brain and the periphery, including the meninges and choroid plexus. In this issue of Immunity, two studies report the dynamics, diversity, and fate of murine BAMs during infection, assigning these cells a neuroprotective role. |
2,329,372 | Echoencephalography of Möbius sequence: A congenital cranial dysinnervation disorder with brainstem calcifications. | Möbius sequence (MBS) previously known as Möbius syndrome is a rare nonprogressive developmental defect of the rhombencephalon leading to congenital abducens (VIth) and facial (VIIth) nerve palsy. Echoencephalography is the first, safe, noninvasive, and cost-effective imaging modality available at bedside. No... |
2,329,373 | Lumboperitoneal Shunt Combined With Ommaya Reservoir Enables Continued Intraventricular Chemotherapy for Leptomeningeal Metastasis With Increased Intracranial Pressure. | Intra-cerebrospinal fluid (CSF) chemotherapy for leptomeningeal metastasis (LM) can be delivered intraventricularly via an Ommaya reservoir. However, hydrocephalus associated with LM can interfere with chemotherapeutic drug distribution, and ventriculoperitoneal shunts can prevent drug distribution to the extra-ventric... |
2,329,374 | Endoscopic transcortical expanded transforaminal transvenous transchoroidal approach to third ventricle lesion resection using an endoport. | To investigate the clinical experience and application value of endoscopic resection of lesions in and around the third ventricle using a transcortical expanded transforaminal transvenous transchoroidal approach with an endoport.</AbstractText>Clinical data and follow-up results of seven patients who underwent the remo... |
2,329,375 | Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. | Foxl2 plays conserved central function in ovarian differentiation and maintenance in several fish species. However, its expression pattern and function in fish embryogenesis are still largely unknown. In this study, we first presented a sequential expression pattern of zebrafish foxl2a and foxl2b during embryo developm... |
2,329,376 | Rethinking the cilia hypothesis of hydrocephalus. | Dysfunction of motile cilia in ependymal cells has been proposed to be a pathogenic cause of cerebrospinal fluid (CSF) overaccumulation leading to ventricular expansion in hydrocephalus, primarily based on observations of enlarged ventricles in mouse models of primary ciliary dyskinesia. Here, we review human and anima... |
2,329,377 | Detection of multidrug-resistant <i>Acinetobacter baumannii</i> by metagenomic next-generation sequencing in central nervous system infection after neurosurgery: A case report. | Central nervous system (CNS) infection is one of the most serious complications after neurosurgery. Traditional clinical methods are difficult to diagnose the pathogen of intracranial infection. Due to recent advances in genomic approaches, especially sequencing technologies, metagenomic next-generation sequencing (mNG... |
2,329,378 | Case report: Prenatal diagnosis of fetal intracranial hemorrhage due to compound mutations in the <i>JAM3</i> gene. | Intracranial hemorrhage is a common complication in preterm infants but occasionally occurs in fetuses. Disruptions of the genes, such as the <i>COL4A1</i> and <i>COL4A2</i> genes<i>,</i> are common genetic causes identified in fetal intracranial hemorrhage; however, the disruptions of the <i>JAM3</i> gene are rarely r... |
2,329,379 | Acute Glycogen Synthase Kinase-3 Inhibition Modulates Human Cardiac Conduction. | Glycogen synthase kinase 3 (GSK-3) inhibition has emerged as a potential therapeutic target for several diseases, including cancer. However, the role for GSK-3 regulation of human cardiac electrophysiology remains ill-defined. We demonstrate that SB216763, a GSK-3 inhibitor, can acutely reduce conduction velocity in hu... |
2,329,380 | Novel insights into the origin and development of CNS macrophage subsets. | The central nervous system (CNS) hosts a variety of immune cells, including two distinct macrophage populations: microglia are found in the parenchyma, whereas CNS-associated macrophages (CAMs) cover the CNS interfaces, such as the perivascular spaces, the meninges and the choroid plexus. Recent studies have given nove... |
2,329,381 | Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice. | Repeat-associated non-AUG translation (RAN translation) is observed in transcripts that are causative for polyglutamine (polyQ) diseases and generates proteins with mono amino acid tracts such as polyalanine (polyA), polyleucine (polyL) and polyserine (polyS) in neurons, astrocytes and microglia. We have previously sho... |
2,329,382 | Postoperative opioid administration and post-traumatic stress symptoms in preschool children after cardiac surgery. | The purpose of this study was to explore relationships between postoperative opioid administration and posttraumatic stress symptoms (PTSS) in preschool-aged children surviving cardiac surgery.</AbstractText>This was a cross-sectional, descriptive study using survey administration and medical chart review. Primary care... |
2,329,383 | Pre-operative external ventricle drainage improves neurological outcomes for patients with traumatic intracerebellar hematomas. | Traumatic intracerebellar hematoma (TICH) is a very rare entity with a high morbidity and mortality rate, and there is no consensus on its optimal surgical management. In particular, whether and when to place external ventricle drainage in TICH patients without acute hydrocephalus pre-operation is still controversial.<... |
2,329,384 | Extracellular vesicles derived from the choroid plexus trigger the differentiation of neural stem cells. | The choroid plexus secrets cerebrospinal fluid (CSF) composed of electrolytes, cytokines, growth factors, metabolites and extracellular vesicles (EVs) that flow through the interconnected brain ventricles. On their course, CSF components can act as signals that affect, for example, neural stem cells (NSCs) residing in ... |
2,329,385 | Sinking skin syndrome in a decompressive craniectomy series: Clinical and radiological features. | The sinking skin syndrome (SSS) is a particular complication after a decompressive craniectomy (DC). It still remains a poorly understood and underestimated entity.</AbstractText>Retrospective case series of craniectomized patients with and without SSS. Clinical and radiological features (DC diameter, shape of craniect... |
2,329,386 | The development of a new, ultra-fine, and flexible neuroendoscope for intracranial observation. | A neuroendoscope is a technical advance that allows surgeons to visualize certain regions of the brain that was previously inaccessible through the use of a surgical microscope. Several neuroendoscope designs have been implemented by other neurosurgeons over the past 5 years. The advantage of a neuroendoscope is the ad... |
2,329,387 | HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression. | Heat-shock protein B (HSPB1) has a neuroprotective effect on brain injury and is a negative regulator of ferroptosis. Therefore, we infer that HSPB1 plays a protective role in hypoxic-ischemic (HI) brain damage by inhibiting ferroptosis. A neonatal rat model of hypoxic-ischemic (HI) brain damage was established. HSPB1 ... |
2,329,388 | Gene therapy using human FMRP isoforms driven by the human <i>FMR1</i> promoter rescues fragile X syndrome mouse deficits. | Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein 1 (FMRP) encoded by the <i>FMR1</i> gene. Gene therapy using adeno-associated virus (AAV) to restore FMRP expression is a promising therapeutic strategy. However, so far AAV gene therapy tests for FXS only utilized rodent FMRPs ... |
2,329,389 | Frontotemporal-Orbitozygomatic Approach and Its Variants: Technical Nuances and Video Illustration. | The frontotemporal-orbitozygomatic (FTOz) approach is an extension of the traditional pterional approach. It provides the neurosurgeon with a wide access to the skull base with minimal or no brain retraction needed; it also offers a panoramic view that enables various trajectories toward the anterior, middle, and centr... |
2,329,390 | Preoperative Management of Neonates With Congenital Heart Disease.<ELocationID EIdType="pii" ValidYN="Y">e2022056415F</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1542/peds.2022-056415F</ELocationID><Abstract><AbstractText>Clinicians caring for neonates with congenital heart disease encounter challenges in cl... | Clinicians caring for neonates with congenital heart disease encounter challenges in clinical care as these infants await surgery or are evaluated for further potential interventions. The newborn with heart disease can present with significant pathophysiologic heterogeneity and therefore requires a personalized therape... |
2,329,391 | Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β<sub>1-42</sub>. | It is possible that increased synthesis of metallothioneins (MTs), Zn2+</sup>-binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn2+</sup> toxicity ferried by amyloid β1-42</sub> (Aβ1-42</sub>).</AbstractText>Judging from the biological half-life (18-20 h) of MTs, the effectiv... |
2,329,392 | Novel <i>TPR::ROS1</i> Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma. | <AbstractText Label="BACKGROUND/AIM" NlmCategory="OBJECTIVE">Although fusion genes involving the proto-oncogene receptor tyrosine kinase ROS1 are rare in pediatric glioma, targeted therapies with small inhibitors are increasingly being approved for histology-agnostic fusion-positive solid tumors.</AbstractText>Here, we... |
2,329,393 | <i>Npas3</i> regulates stemness maintenance of radial glial cells and neuronal migration in the developing mouse cerebral cortex. | The neuronal PAS domain 3 (NPAS3) is a member of the basic helix-loop-helix (bHLH) PAS family of transcription factors and is implicated in psychiatric and neurodevelopmental disorders. <i>NPAS3</i> is robustly expressed in the cortical ventricle zone (VZ), a transient proliferative zone containing progenitor cells, ma... |
2,329,394 | Noninvasive Respiratory Support Does Not Prevent Extubation Failure in High-Risk Norwood Patients. | This study aims to determine whether bilevel positive airway pressure (BiPAP) and continuous positive airway pressure (CPAP) effectively mitigate the risk of extubation failure in children status post-Norwood procedure.</AbstractText>Single-center, retrospective analysis. Extubation events were collected from January 2... |
2,329,395 | Spontaneous regression of colloid cyst on the third ventricle: a case report with the review of the literature.<Pagination><StartPage>397</StartPage><MedlinePgn>397</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">397</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12883-022-02933-6</ELocati... | Hypertrophic obstructive cardiomyopathy (HOCM) is a relatively common disorder. Historically, it has been referred to as idiopathic hypertrophic subaortic stenosis.  HOCM is a significant cause of sudden cardiac death in young people, including well-trained athletes, affecting men and women equally across all race... |
2,329,396 | Comparison of surgery with or without adjuvant radiotherapy in treating central neurocytoma: a single-center retrospective real-world study. | To investigate the efficacy and safety of adjuvant radiotherapy (RT) in patients with central neurocytoma (CN).</AbstractText>The study included 68 patients with CN retrospectively, was further divided into surgery + RT group (31 patients) and surgery alone group (37 patients). Progression-free survi... |
2,329,397 | Shunt freedom in slit ventricle syndrome: using paradoxical ventriculomegaly following lumbar shunting to our advantage. Illustrative cases. | The authors present two cases of paradoxical ventriculomegaly after lumboperitoneal (LP) shunting in patients with slit ventricle syndrome (SVS).</AbstractText>After placement of an LP shunt, both patients rapidly developed radiographic and clinically symptomatic ventricular enlargement. The then generous ventricular c... |
2,329,398 | Conservative management of intraventricular migration of a gelatin sponge: illustrative case. | Gelatin sponges, such as Gelfoam, are used as hemostatic agents during surgery and are generally absorbed over the course of 4-6 weeks in most body cavities. The time course of the dissolution of Gelfoam sponges within the cerebral ventricles has not been described.</AbstractText>The authors present a case of intravent... |
2,329,399 | Neuromedin U-deficient rats do not lose body weight or food intake. | Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic regulation, indicating that NMU is expected to be a potential target for anti-obesity agents. However, in central administration experiments in rats, inconsistent results have bee... |
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