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2,330,200 | HDL: Hybrid Deep Learning for the Synthesis of Myocardial Velocity Maps in Digital Twins for Cardiac Analysis. | Synthetic digital twins based on medical data accelerate the acquisition, labelling and decision making procedure in digital healthcare. A core part of digital healthcare twins is modelbased data synthesis, which permits the generation of realistic medical signals without requiring to cope with the modelling complexity... |
2,330,201 | A Retrospective Study of Intrathecal Pemetrexed Combined With Systemic Therapy for Leptomeningeal Metastasis of Lung Cancer. | <b>Objective</b> This retrospective study aimed to investigate the clinical features of lung cancer patients with leptomeningeal metastasis (LM) and explore the clinical efficacy and tolerance of intrathecal pemetrexed (IP) combined with systemic antitumor therapy. <b>Methods</b> Thirty-four lung cancer patients (11 me... |
2,330,202 | Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis.<Pagination><StartPage>1740</StartPage><EndPage>1749</EndPage><MedlinePgn>1740-1749</MedlinePgn></Pagination><ELocationID EIdType="... | Some clinical studies have indicated the patients with Alzheimer's disease (AD) display an increased risk of cardiovascular disease (CVD). Here, to examine the relationship between AD and CVDs, we investigated the changes in heart function in triple-transgenic late-stage AD model mice (3× Tg-AD; APPSwe, PS1M146V, ... |
2,330,203 | The right ventricle under pressure: Anatomy and imaging in sickness and health. | The right ventricle (RV) is an important structure which serves a multitude of vital physiological functions in health. For many years, the left ventricle has dominated the focus of understanding in both biology and pathophysiology and the RV was felt to be more of a passive structure which rarely had an effect on dise... |
2,330,204 | Risk factors for postresection shunting in children with suprasellar tumor: a retrospective analysis of 124 patients. | Hydrocephalus is one of the most significant comorbidities of pediatric suprasellar tumors. Up to 37.5-68.0% of patients were diagnosed with hydrocephalus at admission. However, after surgical resection of the tumor, 9.3-51.4% of the hydrocephalus will persist and require a ventriculoperitoneal shunt (VPS) surgery. The... |
2,330,205 | Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window. | In this study, second harmonic generation (SHG) and third harmonic generation (THG) spectroscopic imaging were performed on biological samples using a femtosecond laser source in the third near-infrared (NIR) optical window (NIR-III). Using a visible-NIR spectrometer, the SHG and THG signals were simultaneously detecte... |
2,330,206 | Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer's Disease. | Glycogen synthase kinase 3β (GSK3β) is a core protein, with a relevant role in many neurodegenerative disorders including Alzheimer's disease. The enzyme has been largely studied as a potential therapeutic target for several neurological diseases. Unfortunately, preclinical and clinical studies with several... |
2,330,207 | The Clinical and Prognostic Impact of the Choice of Surgical Approach to Fourth Ventricular Tumors in a Single-Center, Single-Surgeon Cohort of 92 Consecutive Pediatric Patients. | A single-institution cohort of 92 consecutive pediatric patients harboring tumors involving the fourth ventricle, surgically treated via</i> the telovelar or transvermian approach, was retrospectively reviewed in order to analyze the impact of surgical route on surgery-related outcomes and cumulative survival.</Abstrac... |
2,330,208 | Intrauterine inflammation exacerbates maladaptive remodeling of the immature myocardium after preterm birth in lambs. | Antenatal conditions that are linked with preterm birth, such as intrauterine inflammation, can influence fetal cardiac development thereby rendering the heart more vulnerable to the effects of prematurity. We aimed to investigate the effect of intrauterine inflammation, consequent to lipopolysaccharide exposure, on po... |
2,330,209 | A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development. | Heart development is topographically complex and requires visualization to understand its progression. No comprehensive 3-dimensional primer of human cardiac development is currently available. We prepared detailed reconstructions of 12 hearts between 3.5 and 8 weeks post fertilization, using Amira® 3D-reconstruct... |
2,330,210 | Morphometric study of the ventricular indexes in healthy ovine BRAIN using MRI. | Sheep (Ovis aries) have been largely used as animal models in a multitude of specialties in biomedical research. The similarity to human brain anatomy in terms of brain size, skull features, and gyrification index, gives to ovine as a large animal model a better translational value than small animal models in neuroscie... |
2,330,211 | LA-ICP-MS bioimaging demonstrated disturbance of metal ions in the brain of Parkinson's disease model mouse undergoing manganese-enhanced MRI. | Manganese-enhanced MRI (MEMRI) is a powerful tool to study neuronal activity and microarchitecture in vivo. Yet the influence of exogenous manganese on the brain of the Parkinson's disease (PD) model mouse is poorly understood. Laser ablation connected to inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging... |
2,330,212 | Intraventricular hemorrhage as complication after spinal surgery. Case report. | Remote intracranial hemorrhage (ICH) is a rare but dreaded complication after spinal surgery. The physiopathology of this phenomenon is closely related to a loss of cerebrospinal fluid (CSF) after an incidental durotomy during spine surgery. The most common remote ICH location is cerebellar, but few articles report int... |
2,330,213 | Protective effect of antioxidants on cardiac function in adult offspring exposed to prenatal overnutrition. | Maternal overnutrition-induced fetal programming predisposes offspring to cardiovascular health issues throughout life. Understanding how these adverse cardiovascular effects are regulated at the maternal-fetal crosstalk will provide insight into the mechanisms of these cardiovascular diseases, which will help in furth... |
2,330,214 | Sonography of fetal holoprosencephaly: a guide to recognize the lesser varieties. | Alobar holoprosencephaly (HPE) is easily detected during a first-trimester screening examination, conversely, recognizing the lesser varieties may be difficult even in the second trimester.</AbstractText>To describe the imaging findings of a cohort of fetuses with holoprosencephaly (HPE) and to elucidate the appearance... |
2,330,215 | The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate. | The choroid plexuses (CPs), located in the brain ventricles, form an interface between the blood and the cerebrospinal fluid named the blood-cerebrospinal barrier, which, by the presence of tight junctions, detoxification enzymes, and membrane transporters, limits the traffic of molecules into the central nervous syste... |
2,330,216 | Extracellular Matrix in Aging Aorta. | The aging population is booming all over the world and arterial aging causes various age-associated pathologies such as cardiovascular diseases (CVDs). The aorta is the largest elastic artery, and transforms pulsatile flow generated by the left ventricle into steady flow to maintain circulation in distal tissues and or... |
2,330,217 | Rosette Forming Glioneural Tumor Treated with Conformal Radiation. | Rosette forming glioneural tumors (RGNT) are a rare type of low-grade brain tumor included in 2007 in WHO classification. Given the benign nature of the disease, a complete surgical excision has been considered optimum. However, a handful of cases have reported the locally aggressive nature of RGNT. In addition, radiat... |
2,330,218 | Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction. | We aim to investigate the mechanisms underlying the beneficial effects of exercise rehabilitation (ER) and/or astragaloside (AST) in counteracting amyloid-beta (Aβ) pathology. Aβ oligomers were microinjected into the bilateral ventricles to induce Aβ neuropathology in rats. Neurobehavioral functions w... |
2,330,219 | Semi-supervised segmentation of echocardiography videos via noise-resilient spatiotemporal semantic calibration and fusion.<Pagination><StartPage>102397</StartPage><MedlinePgn>102397</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.media.2022.102397</ELocationID><ELocationID EIdType="pii" Valid... | We present a novel model for left ventricle endocardium segmentation from echocardiography video, which is of great significance in clinical practice and yet a challenging task due to (1) the severe speckle noise in echocardiography videos, (2) the irregular motion of pathological heart, and (3) the limited training da... |
2,330,220 | Dirofilaria immitis in an Asian small-clawed otter (Aonyx cinereus) from southeastern Louisiana, United States. | A single, male Dirofilaria immitis was found in the right ventricle of a captive, 10-month-old female Asian small-clawed otter (Aonyx cinereus) from East Feliciana parish in Louisiana, USA. Molecular analysis was performed for unequivocal species level identification using the cytochrome c oxidase subunit 1 (cox1) regi... |
2,330,221 | Influence of dietary lycopene on growth performance, antioxidant status, blood parameters and mortality in broiler chicken with cold-induced ascites. | The aim of this study was to determine the effects of dietary lycopene supplementation on growth performance and antioxidant status of broiler chickens exposed to cold environment to induce ascites. Three hundred male chickens were exposed full-day to cold stress (CT, 10°C) starting from day 15 of age until the en... |
2,330,222 | Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. | Using a partial hippocampal cholinergic denervation model, we assessed the effects of the RGTA<sup>®</sup> named OTR4132, a synthetic heparan-mimetic biopolymer with neuroprotective/neurotrophic properties. Long-Evans male rats were injected with the cholinergic immunotoxin 192 IgG-saporin into the medial septum/d... |
2,330,223 | A Targeted Association Study of Blood-Brain Barrier Gene SNPs and Brain Atrophy. | The blood-brain barrier (BBB) is formed by a high-density lining of endothelial cells, providing a border between circulating blood and the brain interstitial fluid. This structure plays a key role in protecting the brain microenvironment by restricting passage of certain molecules and circulating pathogens.</AbstractT... |
2,330,224 | A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma. | Glioblastoma (GBM) is one of the most malignant types of tumors in the central nervous system, and the 5-year survival remains low. Several studies have shown that preoperative peripheral blood tests and preoperative conventional Magnetic Resonance Imaging (MRI) examinations affect the prognosis of GBM patients. Theref... |
2,330,225 | Optimization of Left Ventricle Pace Maker Location Using Echo-Based Fluid-Structure Interaction Models. | Cardiac pacing has been an effective treatment in the management of patients with bradyarrhythmia and tachyarrhythmia. Different pacemaker location has different responses, and pacemaker effectiveness to each individual can also be different. A novel image-based ventricle animal modeling approach was proposed to optimi... |
2,330,226 | MRI-Based Classification of Neuropsychiatric Systemic Lupus Erythematosus Patients With Self-Supervised Contrastive Learning. | <AbstractText Label="INTRODUCTION/PURPOSE" NlmCategory="OBJECTIVE">Systemic lupus erythematosus (SLE) is a chronic auto-immune disease with a broad spectrum of clinical presentations, including heterogeneous neuropsychiatric (NP) syndromes. Structural brain abnormalities are commonly found in SLE and NPSLE, but their r... |
2,330,227 | Current Perspectives on the Diagnosis and Management of Healthcare-Associated Ventriculitis and Meningitis. | Ventriculitis or post-neurosurgical meningitis or healthcare-associated ventriculitis and meningitis (VM) is a severe infection that complicates central nervous system operations or is related to the use of neurosurgical devices or drainage catheters. It can further deteriorate patients who have already presented signi... |
2,330,228 | MicroRNA-193b-3p reduces oxidative stress and mitochondrial damage in rats with cerebral ischemia-reperfusion injury via the seven in absentia homolog 1/Jun N-terminal kinase pathway. | Ischemic stroke is one of the major causes of death and disability among adults. This study sought to explore the mechanism of microRNA (miR)-193b-3p in rats with cerebral ischemia-reperfusion (I/R) injury. The cerebral I/R injury models of rats were established using the suture-occluded method. The pathological change... |
2,330,229 | Clinical characteristics of glioblastoma with metastatic spinal dissemination. | Metastatic spinal dissemination (MSD) is a rare phenomenon in glioblastoma (GBM). The study aimed to analyze the clinical characteristics of GBM patients with MSD.</AbstractText>Fifteen GBM patients with MSD, who were treated and followed up with at the Department of Oncology, Beijing Shijitan Hospital, Capital Medical... |
2,330,230 | Efficacy and safety of intraventricular polymyxin B plus continuous ventricular drainage for the treatment of intracranial infection caused by drug-resistant Acinetobacter baumannii. | The bacterial resistance rate has risen in recent years, and polymyxin B has been used more frequently to treat severe intracranial infection. This study aimed to investigate the clinical efficacy and safety profiles of intraventricular polymyxin B plus continuous ventricular drainage for the treatment of intracranial ... |
2,330,231 | Endoscopic Management of Quadrigeminal Arachnoid Cyst with Neuronavigation Guidance. | Quadrigeminal cistern arachnoid cysts (ACs) are usually asymptomatic, may be accidental findings during radiological evaluation, and are rare (5%-10% of all intracranial ACs). We report a case of type I quadrigeminal cistern AC managed via navigation-guided cystoventriculostomy followed by endoscopic third ventriculost... |
2,330,232 | Single cardiomyocytes from papillary muscles show lower preload-dependent activation of force compared to cardiomyocytes from the left ventricular free wall.<Pagination><StartPage>127</StartPage><EndPage>136</EndPage><MedlinePgn>127-136</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.yjmcc.202... | Efficient pumping of the healthy left ventricle (LV) requires heterogeneities in mechanical function of individual cardiomyocytes (CM). Deformation of sub-endocardial (Endo) tissue is greater than that of sub-epicardial (Epi) regions. Papillary muscles (PM), often considered to be part of Endo tissue, show lower beat-b... |
2,330,233 | 3-Step didactic white matter dissection of human cerebellum: Micro-neuroanatomical training. | A thorough understanding of cerebellum anatomy is essential in 4th ventricle approaches (more frequent in pediatric neurosurgery), avoiding relevant complications such as cerebellar mutism. The aim of the present work is to show the feasibility of a didactic dissection of human cerebellum focusing on cerebellar peduncl... |
2,330,234 | Multiple-mouse magnetic resonance imaging with cryogenic radiofrequency probes for evaluation of brain development. | Multiple-mouse magnetic resonance imaging (MRI) increases scan throughput by imaging several mice simultaneously in the same magnet bore, enabling multiple images to be obtained in the same time as a single scan. This increase in throughput enables larger studies than otherwise feasible and is particularly advantageous... |
2,330,235 | Irx5 and transient outward K<sup>+</sup> currents contribute to transmural contractile heterogeneities in the mouse ventricle. | Previous studies have established that transmural gradients of the fast transient outward K<sup>+</sup> current (<i>I</i><sub>to,f</sub>) correlate with regional differences in action potential (AP) profile and excitation-contraction coupling (ECC) with high <i>I</i><sub>to,f</sub> expression in the epimyocardium (EPI)... |
2,330,236 | Normal pressure hydrocephalus: Neurophysiological and neuropsychological aspects: a narrative review. | Idiopathic normal pressure hydrocephalus (NPH) is a syndrome that affects elderly people and is characterized by excessive accumulation of cerebrospinal fluid in the brain ventricles. Diagnosis is based on the evaluation of clinical symptoms, which consists of a classic triad (Hakim triad), gait disturbances, cognitive... |
2,330,237 | Intracranial Epstein-Barr virus-associated smooth muscle tumor with superimposed cryptococcal infection: A case report. | Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are rare, virally-induced malignancies that occur almost exclusively in immunocompromised individuals. We report a very rare case of a dura-based EBV-SMT with superimposed local cryptococcal infection.</AbstractText>An adult male with a history of untreated a... |
2,330,238 | Familial colloid cysts: not a chance occurrence. | Colloid cysts are rare, benign brain tumors of the third ventricle with an estimated population prevalence of 1 in 5800. Sudden deterioration and death secondary to obstructive hydrocephalus are well-described presentations in patients with a colloid cyst. Although historically conceptualized as driven by sporadic gene... |
2,330,239 | Regulation of collagen deposition in the trout heart during thermal acclimation. | The passive mechanical properties of the vertebrate heart are controlled in part by the composition of the extracellular matrix (ECM). Changes in the ECM, caused by increased blood pressure, injury or disease can affect the capacity of the heart to fill with blood during diastole. In mammalian species, cardiac fibrosis... |
2,330,240 | Dihydroquercetin ameliorates LPS-induced neuroinflammation and memory deficit. | Dihydroquercetin (DHQ) is a pentahydroxyflavanone that has been used as an important suppliment against oxidative stress related inflammation and neuroinflammation. Neuroinflammation, which is the activation of the defense mechanism of the central nervous system, upon exposure to stimuli like amyloid β, Lewy bodi... |
2,330,241 | Deficiency of <i>nde1</i> in zebrafish induces brain inflammatory responses and autism-like behavior. | The cytoskeletal protein NDE1 plays an important role in chromosome segregation, neural precursor differentiation, and neuronal migration. Clinical studies have shown that NDE1 deficiency is associated with several neuropsychiatric disorders including autism. Here, we generated <i>nde1</i> homologous deficiency zebrafi... |
2,330,242 | Cerebellar liponeurocytoma with an unusual metastatic CSF spinal seeding. | Cerebellar liponeurocytoma is rare intracranial tumor appearing mostly in the posterior fossa.</AbstractText>We hereby report a long follow-up of a case of cerebellar liponeurocytoma in a 60-year-old female. At first, she presented in March of 2010 with the symptoms of hydrocephalus and was found to have a lesion locat... |
2,330,243 | Numerical biomechanics modelling of indirect mitral annuloplasty treatments for functional mitral regurgitation.<Pagination><StartPage>211464</StartPage><MedlinePgn>211464</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">211464</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1098/rsos.211464</ELoc... | Mitral valve regurgitation (MR) is a common valvular heart disease where an improper closure leads to leakage from the left ventricle into the left atrium. There is a need for less-invasive treatments such as percutaneous repairs for a large inoperable patient population. The aim of this study is to compare several ind... |
2,330,244 | Microsurgical Technique for Resection of a Cerebellopontine Angle Epidermoid Tumor. | Epidermoid tumors are slow-growing, benign, congenital lesions.<sup>1</sup> They commonly arise in the cerebellopontine angle, fourth ventricle, suprasellar region, or spinal cord.<sup>2</sup> Symptoms may include hearing loss, facial pain, and headaches. The management options include observation or surgical resection... |
2,330,245 | Heterogeneity of quiescent and active neural stem cells in the postnatal brain. | In the postnatal mammalian brain, neurogenic activity is retained in anatomically restricted areas, driven by pools of Neural Stem Cells (NSCs). These cells and their progeny have been studied intensively as potential targets for regenerative treatments, aiming at either their <i>in situ</i> manipulation or their use a... |
2,330,246 | p140Cap Controls Female Fertility in Mice Acting <i>via</i> Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons. | p140Cap, encoded by the gene <i>SRCIN1</i> (<i>SRC kinase signaling inhibitor 1)</i>, is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic mechanisms. <i>p140Cap</i> knock-out (KO) female mice show severe hypofertility, delayed puberty onset, altered estrus... |
2,330,247 | Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia. | The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical thickness and investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data were acquired in 24 patients with treatment... |
2,330,248 | The dysfunctional right ventricle: the importance of multi-modality imaging.<Pagination><StartPage>885</StartPage><EndPage>897</EndPage><MedlinePgn>885-897</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ehjci/jeac037</ELocationID><Abstract><AbstractText>Assessment of right ventricular (RV) func... | Assessment of right ventricular (RV) function is crucial for the evaluation of the dyspnoeic patient and/or with systemic venous congestion and provides powerful prognostic insights. It can be performed using different imaging modalities including standard and advanced echocardiographic techniques, cardiac magnetic res... |
2,330,249 | Reduction in the cerebrospinal fluid protein level after bevacizumab treatment in patients with optic pathway low-grade gliomas. | Optic pathway gliomas (OPG) can cause elevated cerebrospinal fluid (CSF) protein concentrations. We report on two patients with suprasellar low-grade gliomas and high CSF protein levels (590 and 551 mg/dl) that precluded shunt implantation. After two and three doses of bevacizumab, respectively, the levels dropped... |
2,330,250 | Bifocal lesions have a poorer treatment outcome than a single lesion in adult patients with intracranial germinoma. | Intracranial germinoma (IG) rarely occurs in adults. Its optimal treatment strategy is unclear. We evaluated the outcomes of radiotherapy in adults with intracranial germinoma. Data of 29 adult patients (age, 18-52 years; median age, 24.3 years) with IG treated with radiotherapy at Taipei Veterans General Hospital were... |
2,330,251 | Anemia and outcomes following left ventricular assist device implantation.<Pagination><StartPage>1626</StartPage><EndPage>1635</EndPage><MedlinePgn>1626-1635</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/aor.14224</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND"... | Few data are available on the prevalence of right ventricle (RV) systolic dysfunction, assessed including RV strain, and RV to pulmonary artery (PA) coupling in patients with aortic stenosis (AS) submitted to TAVI and the early effect of the procedure. We performed standard and speckle tracking echocardiography in 80 p... |
2,330,252 | Effects of lysophosphatidic acid receptor 5 on NLRC4 inflammasome in brain tissues of transient cerebral ischemia/reperfusion rat. | To explore whether LPA5 was involved in the inflammatory responses in CI/R injury by regulation of NLRC4.</AbstractText>The cerebral I/R model in rats was constructed with ischemia of 2h and different time points of reperfusion. After that, western blot was used to determine protein expression (LPA5, NLRC4, AIM2, caspa... |
2,330,253 | Heart injuries related to cardiopulmonary resuscitation: a risk often overlooked. | Current studies focus primarily on skeletal injuries following cardiopulmonary resuscitation (CPR). Few studies report on intrathoracic injuries (ITI) and none, to our knowledge, focus exclusively on cardiovascular injuries related to cardiac massage. This study was based on autopsy findings and assessed the incidence ... |
2,330,254 | AI-based medical e-diagnosis for fast and automatic ventricular volume measurement in patients with normal pressure hydrocephalus. | Based on CT and MRI images acquired from normal pressure hydrocephalus (NPH) patients, using machine learning methods, we aim to establish a multimodal and high-performance automatic ventricle segmentation method to achieve an efficient and accurate automatic measurement of the ventricular volume. First, we extract the... |
2,330,255 | Intracranial ependymal cyst - A modern systematic review with a pathway to diagnosis. | Intracranial ependymal cysts (IECs) are rare, histologically benign neuroepithelial cysts that mostly occur in the cerebral parenchyma. The majority of these cysts are clinically silent and discovered incidentally, but when symptomatic they may compress surrounding structures, thus surgical intervention is needed. The ... |
2,330,256 | Influence of interaction of cerebral fluids on ventricular deformation: A mathematical approach. | This paper describes the effects of the interaction of cerebral fluids (arterial, capillary and venous blood, cerebrospinal fluid) on ventricular wall displacement and periventricular pressure using a mathematical multiphase poroelasticity model for the cerebral parenchyma. The interaction of cerebral fluids is given b... |
2,330,257 | Assessing Fluid Intolerance with Doppler Ultrasonography: A Physiological Framework.<ELocationID EIdType="pii" ValidYN="Y">12</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/medsci10010012</ELocationID><Abstract><AbstractText>Ultrasonography is becoming the favored hemodynamic monitoring utensil of emergent... | Ultrasonography is becoming the favored hemodynamic monitoring utensil of emergentologists, anesthesiologists and intensivists. While the roles of ultrasound grow and evolve, many clinical applications of ultrasound stem from qualitative, image-based protocols, especially for diagnosing and managing circulatory failure... |
2,330,258 | Laryngeal Cavernous Lymphangioma in an Adult Patient. | Lymphangiomas are uncommon congenital lesions of the lymphatic system, and most of them are detected by the second year of life. Although head and neck region is the most common location, laryngeal involvement isextremely rare, and the literature is largely limited to few case reports.</AbstractText>A 51-year-old male ... |
2,330,259 | Fetal Ventriculomegaly: A Review of Literature. | Fetal ventriculomegaly refers to ventricular enlargement that is diagnosed prenatally. It is one of the most common fetal anomalies. The diagnosis is made by ultrasound when the arterial diameter of the ventricle is more than 10 mm. Once it is diagnosed, further evaluation by detailed ultrasound, fetal MRI, and genetic... |
2,330,260 | miR-155-5p in Extracellular Vesicles Derived from Choroid Plexus Epithelial Cells Promotes Autophagy and Inflammation to Aggravate Ischemic Brain Injury in Mice. | Ischemic stroke is a common disease of the central nervous system, and ischemic brain injury (IBI) is its main manifestation. Recently, extracellular vesicles (EVs) have been strongly related to the diagnosis and treatment of IBI. However, the underlying mechanism of their effects remains enigmatic. In the present stud... |
2,330,261 | Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus. | Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved in plaque formation in Alzheimer`s diseases (AD). A potential role of such vesicles in AD pathology is unexplored.</AbstractText>In a case-cont... |
2,330,262 | Comparison of microscopic and endoscopic resection of third-ventricular colloid cysts: A systematic review and meta-analysis. | Colloid cysts are uncommon benign lesions. There is a lack of consensus regarding the preferred surgical strategy for colloid cyst resection; the technique with the optimal rates of remission, recurrence, mortality, and complications is debatable.</AbstractText>To determine surgical outcomes, we performed a systematic ... |
2,330,263 | Inhibiting microRNA-142-5p improves learning and memory in Alzheimer's disease rats via targeted regulation of the PTPN1-mediated Akt pathway. | MicroRNAs (miRNAs) have been recognized as possible biomarkers for Alzheimer's disease (AD). MiR-142-5p has been reported to be abnormally expressed in brain tissues. However, the role of miR-142-5p in AD pathogenesis keeps unclear. This study aimed to investigate the effect of miR-142-5p on the learning and memory of ... |
2,330,264 | A potential future Fontan modification: preliminary in vitro data of a pressure-generating tube from engineered heart tissue. | Univentricular malformations are severe cardiac lesions with limited therapeutic options and a poor long-term outcome. The staged surgical palliation (Fontan principle) results in a circulation in which venous return is conducted to the pulmonary arteries via passive laminar flow. We aimed to generate a contractile sub... |
2,330,265 | Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis. | The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the choroid plexus is similarly involved in MS and in neuromyelitis optica spectrum disorder (NMOSD). Thu... |
2,330,266 | Delayed Minocycline Treatment Ameliorates Hydrocephalus Development and Choroid Plexus Inflammation in Spontaneously Hypertensive Rats. | Hydrocephalus is a complicated disorder that affects both adult and pediatric populations. The mechanism of hydrocephalus development, especially when there is no mass lesion present causing an obstructive, is poorly understood. Prior studies have demonstrated that spontaneously hypertensive rats (SHRs) develop hydroce... |
2,330,267 | Severe Acute Hepatic Dysfunction Induced by Ammonium Acetate Treatment Results in Choroid Plexus Swelling and Ventricle Enlargement in the Brain. | Hepatic encephalopathy is a major cause of liver failure. However, the pathophysiological role of ventricle enlargement in brain edema remains unclear. Here, we used an acute hepatic encephalopathy mouse model to examine the sequential pathological changes in the brain associated with this condition. We collected tissu... |
2,330,268 | Visualization of the Third Ventricle, the Future Cavum Septi Pellucidi, and the Cavum Veli Interpositi at 11+3 to 13+6 Gestational Weeks on 3D Transvaginal Ultrasound Including Normative Data. | To show the development of the third ventricle, commissural plate, future cavum septi pellucidi, and cavum veli interpositi in weeks 12-14 by transvaginal 3D ultrasound.</AbstractText>This is a prospective transvaginal 3D study carried out to define the third ventricle and the diencephalic midline structures surroundin... |
2,330,269 | Semi-Quantitative Scoring of Late Gadolinium Enhancement of the Left Ventricle in Patients with Ischemic Cardiomyopathy: Improving Interobserver Reliability and Agreement Using Consensus Guidance from the Asian Society of Cardiovascular Imaging-Practical Tutorial (ASCI-PT) 2020. | This study aimed to evaluate the effect of implementing the consensus statement from the Asian Society of Cardiovascular Imaging-Practical Tutorial 2020 (ASCI-PT 2020) on the reliability of cardiac MR with late gadolinium enhancement (CMR-LGE) myocardial viability scoring between observers in the context of ischemic ca... |
2,330,270 | Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections. | The use of antisense oligonucleotides (AONs) is a promising therapeutic strategy for central nervous system disorders. However, the delivery of AONs to the central nervous system is challenging because their size does not allow them to diffuse over the blood-brain barrier (BBB) when injected systemically. The BBB can b... |
2,330,271 | An audit of endoscopic third ventriculostomy (ETV) in a regional paediatric neurosurgical centre assessing the accuracy and feasibility of the ETV success score. | Endoscopic third ventriculostomy success score (ETVss) is widely utilised to predict outcomes for ETV. Accurate prediction of success for a procedure is of vital importance both for selecting the optimal management plan and for obtaining informed consent. Existing literature demonstrates a variety of opinions on the ac... |
2,330,272 | A Rare Case of Dandy-Walker Syndrome. | Dandy-Walker syndrome (DWS) is a rare congenital malformation characterized by hypoplasia of the cerebellar vermis and its upward rotation and cystic enlargement of the fourth ventricle. The clinical manifestations include psychomotor retardation, ataxia and hydrocephalus. We report a case of 16-year-old female patient... |
2,330,273 | Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors. | Following the decline of neurogenesis at birth, progenitors of the subventricular zone (SVZ) remain mostly in a quiescent state in the adult human brain. The mechanisms that regulate this quiescent state are still unclear. Here, we isolate CD271<sup>+</sup> progenitors from the aged human SVZ for single-cell RNA sequen... |
2,330,274 | Treatment of Posthemorrhagic Hydrocephalus. | The incidence of intraventricular hemorrhage (IVH) has overall declined to 15% to 20% of preterm infants with birth weight less than 1500 g. One of the major complications of severe IVH is posthemorrhagic ventricular dilation (PHVD). Nearly 10% of all infants with IVH and 20% of infants with severe IVH will develop pro... |
2,330,275 | Impact of IFN-γ Deficiency on the Cardiomyocyte Function in the First Stage of Experimental Chagas Disease. | Chagas disease (CD) is caused by the parasitic protozoan <i>T. cruzi.</i> The progression of CD in ~30% of patients results in Chagasic Cardiomyopathy (CCM). Currently, it is known that the inflammatory system plays a significant role in the CCM. Interferon-gamma (IFN-γ) is the major cytokine involved in parasite... |
2,330,276 | Resolution of Papilledema Following Ventriculoperitoneal Shunt or Endoscopic Third Ventriculostomy for Obstructive Hydrocephalus: A Pilot Study. | <i>Background and Objectives:</i> Ventriculoperitoneal Shunt (VPS) and Endoscopic Third Ventriculostomy (ETV) are both gold standard procedures to reduce intracranial pressure (ICP) in patients with obstructive hydrocephalus, which often results in papilledema. This comparative study was carried out at the Department o... |
2,330,277 | Comparison of the Functional State and Motor Skills of Patients after Cerebral Hemisphere, Ventricular System, and Cerebellopontine Angle Tumor Surgery. | Brain tumor location is an important factor determining the functional state after brain tumor surgery. We assessed the functional state and course of rehabilitation of patients undergoing surgery for brain tumors and assessed the location-dependent risk of loss of basic motor skills and the time needed for improvement... |
2,330,278 | Surgical Treatment of Long-Standing Overt Ventriculomegaly in Adults (LOVA): A Comparative Case Series between Ventriculoperitoneal Shunt (VPS) and Endoscopic Third Ventriculostomy (ETV). | <i>Background:</i> Long-standing overt ventriculomegaly in adults (LOVA) is an uncommon type of adult chronic hydrocephalus. In recent years, conflicting case series described different outcomes after treatment of LOVA with endoscopic third ventriculostomy (ETV) or ventriculoperitoneal shunt (VPS). The aim of this stud... |
2,330,279 | Expanding the Clinical Phenotype of 19q Interstitial Deletions: A New Case with 19q13.32-q13.33 Deletion and Short Review of the Literature. | 19q13 microdeletion syndrome is a very rare genetic disease characterized by pre- and postnatal growth retardation, intellectual disability, expressive language impairment, ectodermal dysplasia, and slender habitus. Since the description of the first case in 1998, less than 30 cases have been reported worldwide. This a... |
2,330,280 | Diagnostic Value of Preoperative Electrodiagnostic Analysis in a Patient with Facial Palsy and a Large Vestibular Schwannoma: Case Report. | Although radiologic methods confirm the diagnosis of patients with large vestibular schwannomas, these methods usually indicate only the size of the tumor and its possible nerve compression. Electrodiagnostic methods can reveal the functional state of the nerves, particularly the trigeminal and facial nerves, as well a... |
2,330,281 | Quantifying Myocardial Strain of the Left Ventricle in Normal People Using Feature-Tracking Based on Computed Tomography Imaging. | The objective was to evaluate the normal value of left ventricular myocardial strain using the computed tomography feature-tracking technique and to explore the correlation between myocardial strains and cardiac function parameters.</AbstractText>Participants suspected of coronary heart disease were selected from 17 Au... |
2,330,282 | Cardiac Computed Tomography Radiomics-Based Approach for the Detection of Left Ventricular Remodeling in Patients with Arterial Hypertension. | The aim of the study is to verify the feasibility of a radiomics based approach for the detection of LV remodeling in patients with arterial hypertension. Cardiac Computed Tomography (CCT) and clinical data of patients with and without history of arterial hypertension were collected. In one image per patient, on a 4-ch... |
2,330,283 | Oxidative Stress and Diseases Associated with High-Altitude Exposure. | Several diseases associated with high-altitude exposure affect unacclimated individuals. These diseases include acute mountain sickness (AMS), high-altitude cerebral edema (HACE), high-altitude pulmonary edema (HAPE), chronic mountain sickness (CMS), and, notably, high-altitude pulmonary hypertension (HAPH), which can ... |
2,330,284 | <i>mdka</i> Expression Is Associated with Quiescent Neural Stem Cells during Constitutive and Reactive Neurogenesis in the Adult Zebrafish Telencephalon. | In contrast to mammals, adult zebrafish display an extraordinary capacity to heal injuries and repair damage in the central nervous system. Pivotal for the regenerative capacity of the zebrafish brain at adult stages is the precise control of neural stem cell (NSC) behavior and the maintenance of the stem cell pool. Th... |
2,330,285 | Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension. | Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to sustained pulmonary vasoconstriction and excessive obliterative pulmonary vascular remodeling. Work over the last decade has led to the identi... |
2,330,286 | Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat. | Mutations of the <i>TMEM70</i> gene disrupt the biogenesis of the ATP synthase and represent the most frequent cause of autosomal recessive encephalo-cardio-myopathy with neonatal onset. Patient tissues show isolated defects in the ATP synthase, leading to the impaired mitochondrial synthesis of ATP and insufficient en... |
2,330,287 | Choroid Plexus in Alzheimer's Disease-The Current State of Knowledge. | The choroid plexus (CP), located in each of the four ventricles of the brain, is formed by a monolayer of epithelial cells that surrounds a highly vascularized connective tissue with permeable capillaries. These cells are joined by tight junctions forming the blood-cerebrospinal fluid barrier (BCSFB), which strictly re... |
2,330,288 | Generation and Characterization of an Inducible Cx43 Overexpression System in Mouse Embryonic Stem Cells. | Connexins (Cx) are a large family of membrane proteins that can form intercellular connections, so-called gap junctions between adjacent cells. Cx43 is widely expressed in mammals and has a variety of different functions, such as the propagation of electrical conduction in the cardiac ventricle. Despite Cx43 knockout m... |
2,330,289 | Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study. | Dandy-Walker malformation (DWM) is a common prenatally diagnosed cerebellar malformation, characterized by cystic dilatation of the fourth ventricle, upward rotation of the hypoplastic vermis, and posterior fossa enlargement with torcular elevation. DWM is associated with a broad spectrum of neurodevelopmental abnormal... |
2,330,290 | Effector mechanisms in the baroreceptor control of blood pressure. | While the effects of changing heart rate and systemic vascular resistance have been generally understood and appreciated, the effects of changes in left ventricular contractility on end-systolic volume may have been less understood and appreciated and the effects of changes in venous capacitance on end-diastolic volume... |
2,330,291 | No evidence for pericardial restraint in the snapping turtle (<i>Chelydra serpentina</i>) following pharmacologically induced bradycardia at rest or during exercise.<Pagination><StartPage>R389</StartPage><EndPage>R399</EndPage><MedlinePgn>R389-R399</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1152... | Most animals elevate cardiac output during exercise through a rise in heart rate (<i>f</i><sub>H</sub>), whereas stroke volume (V<sub>S</sub>) remains relatively unchanged. Cardiac pacing reveals that elevating <i>f</i><sub>H</sub> alone does not alter cardiac output, which is instead largely regulated by the periphera... |
2,330,292 | Persisting embryonal infundibular recess in a case of TITF-1 gene mutation. | The thyroid transcription factor 1 (TITF-1) gene plays an important role in the development of the ventral forebrain, thyroid and lungs. Mutations of this gene are known to cause benign hereditary chorea (BHC) and can cause the full spectrum of abnormalities seen in the brain-thyroid-lung syndrome. Abnormalities of the... |
2,330,293 | Seasonal changes of electrophysiological heterogeneities in the rainbow trout ventricular myocardium. | Thermal adaptation in fish is accompanied by morphological and electrophysiological changes in the myocardium. Little is known regarding seasonal changes of spatiotemporal organization of ventricular excitation and repolarization processes. We aimed to evaluate transmural and apicobasal heterogeneity of depolarization ... |
2,330,294 | Ventricular Infusion and Nanoprobes Identify Cerebrospinal Fluid and Glymphatic Circulation in Human Nerves. | Growing evidence suggests that cerebrospinal fluid circulates in human nerves. Several conditions encountered by the plastic surgeon may be related to dysregulation of this system, including nerve transection, stretch injuries, and peripheral neuropathy. The purpose of this study was to show how ventricular infusion an... |
2,330,295 | Altered subcortical and cortical brain morphology in adult women with 47,XXX: a 7-Tesla magnetic resonance imaging study. | Triple X syndrome (47,XXX) is a relatively common sex chromosomal aneuploidy characterized by the presence of a supernumerary X chromosome in females and has been associated with a variable cognitive, behavioural and psychiatric phenotype. 47,XXX may serve as a suitable model for studying the effect of genetic architec... |
2,330,296 | Live Tissue Imaging Reveals Distinct Transcellular Pathways for Organic Cations and Anions at the Blood-Cerebrospinal Fluid Barrier. | Formed by the choroid plexus epithelial (CPE) cells, the blood-cerebrospinal fluid barrier (BCSFB) plays an active role in removing drugs, toxins, and metabolic wastes from the brain. Several organic cation and anion transporters are expressed in the CPE cells, but how they functionally mediate transepithelial transpor... |
2,330,297 | Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter. | Hydrocephalus is a neurological disease with an incidence of 80-125 per 100,000 births in the United States. Neuropathology comprises ventriculomegaly, periventricular white matter (PVWM) alterations, inflammation, and gliosis. We hypothesized that hydrocephalus in a pig model is associated with subventricular and PVWM... |
2,330,298 | Four-dimensional computed tomography of the left ventricle, Part II: Estimation of mechanical activation times. | We demonstrate the viability of a four-dimensional X-ray computed tomography (4DCT) imaging system to accurately and precisely estimate mechanical activation times of left ventricular (LV) wall motion. Accurate and reproducible timing estimates of LV wall motion may be beneficial in the successful planning and manageme... |
2,330,299 | Persisting embryonal infundibular recess (PEIR) and transsphenoidal-transsellar encephaloceles: distinct entities or constituents of one continuum? | Persisting embryonal infundibular recess (PEIR) is a very rare anomaly of the floor of the third ventricle in which the embryonic morphology of the infundibular recess (IR) persists. The exact underlying mechanism of development of PEIR is unknown, and the anomaly has been reported as an isolated finding or in associat... |
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