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2,330,600 | Progesterone receptor-Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats. | Neural circuits in female rats are exposed to sequential estradiol and progesterone to regulate the release of luteinizing hormone (LH) and ultimately ovulation. Estradiol induces progesterone receptors (PGRs) in anteroventral periventricular nucleus (AVPV) kisspeptin neurons, and as estradiol reaches peak concentratio... |
2,330,601 | Sox-positive cell population in the adult cerebellum increases upon tissue degeneration. | Adult neurogenesis is well-described in the subventricular and subgranular zones of the mammalian brain. Recent observations that resident glia express stem cell markers in some areas of the brain not traditionally associated with neurogenesis hint to a possible role in tissue repair. The Bergmann glia (BG) population ... |
2,330,602 | Changes of healthy brain tissue after salvage radiotherapy of glioblastoma. | Salvage radiotherapy (SRT) with photons is a valid treatment option for patients suffering from recurrent glioblastoma (GBM). However, the tolerance of healthy brain to ionizing radiation (IR) is limited. The aim of this study was to determine to what extent brain structures in the radiographically tumor-free hemispher... |
2,330,603 | Erratum: A Dense RNN for Sequential Four-Chamber View Left Ventricle Wall Segmentation and Cardiac State Estimation. | [This corrects the article DOI: 10.3389/fbioe.2021.696227.]. |
2,330,604 | Cerebellar Liponeurocytoma Mimicking Medulloblastoma: Case Report of a Childhood and Literature Review. | Cerebellar liponeurocytoma is a rare benign neoplasm of the central nervous system, which arises mainly in adult patients with only 3 cases reported in children. Due to its rarity, the diagnosis and treatment strategies for cerebellar liponeurocytoma remain unclear. The purpose of this study was to explore the epidemio... |
2,330,605 | Lipopolysaccharide, Identified Using an Antibody and by PAS Staining, Is Associated With <i>Corpora amylacea</i> and White Matter Injury in Alzheimer's Disease and Aging Brain. | <i>Corpora amylacea</i> (CA) increase in number and size with aging. Their origins and functions remain unknown. Previously, we found that Alzheimer's disease (AD) brains have more <i>CA</i> in the periventricular white matter (PVWM) compared to aging controls. In addition, CA is associated with neurodegeneration as in... |
2,330,606 | The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis. | Trigeminal neuralgia (TN) is a severe chronic neuropathic pain. Despite numerous available medical interventions, the therapeutic effects are not ideal. To control the pain attacks, the need for more contemporary drugs continues to be a real challenge. Our previous study reported that Ca<sup>2+</sup>-activated K<sup>+<... |
2,330,607 | The cell type-specific ER membrane protein UGS148 is not essential in mice. | Genomes of higher eukaryotes encode many uncharacterized proteins, and the functions of these proteins cannot be predicted from the primary sequences due to a lack of conserved functional domains. In this study, we focused on a poorly characterized protein UGS148 that is highly expressed in a specialized cell type call... |
2,330,608 | Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH. | In cardiomyocytes, acute disturbances to intracellular pH (pHi) are promptly corrected by a system of finely tuned sarcolemmal acid-base transporters. However, these fluxes become thermodynamically re-balanced in acidic environments, which inadvertently causes their set-point pHi to fall outside the physiological range... |
2,330,609 | Experimental Hemodynamics Within the Penn State Fontan Circulatory Assist Device.<ELocationID EIdType="pii" ValidYN="Y">071004</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1115/1.4053210</ELocationID><Abstract><AbstractText>For children born with a single functional ventricle, the Fontan operation bypasses th... | For children born with a single functional ventricle, the Fontan operation bypasses the right ventricle by forming a four-way total cavopulmonary connection and adapts the existing ventricle for the systemic circulation. However, upon reaching adulthood, many Fontan patients exhibit low cardiac output and elevated veno... |
2,330,610 | Pathophysiology of the choroid plexus in brain diseases. | The choroid plexus, located in the ventricular system of the central nervous system (CNS), obtains numerous roles critical for the proper development and operating of the CNS. The functions range from the best-known ones of the barrier and cerebrospinal fluid (CSF) producer, through participation in immune answer, 'nou... |
2,330,611 | Adult Neural Stem Cell Migration Is Impaired in a Mouse Model of Alzheimer's Disease. | Neurogenesis in the adult brain takes place in two neurogenic niches: the ventricular-subventricular zone (V-SVZ) and the subgranular zone. After differentiation, neural precursor cells (neuroblasts) have to move to an adequate position, a process known as neuronal migration. Some studies show that in Alzheimer's disea... |
2,330,612 | Motion Extraction of the Right Ventricle from 4D Cardiac Cine MRI Using A Deep Learning-Based Deformable Registration Framework. | Cardiac Cine Magnetic Resonance (CMR) Imaging has made a significant paradigm shift in medical imaging technology, thanks to its capability of acquiring high spatial and temporal resolution images of different structures within the heart that can be used for reconstructing patient-specific ventricular computational mod... |
2,330,613 | Segmentation of Cardiac Structures via Successive Subspace Learning with Saab Transform from Cine MRI. | Assessment of cardiovascular disease (CVD) with cine magnetic resonance imaging (MRI) has been used to non-invasively evaluate detailed cardiac structure and function. Accurate segmentation of cardiac structures from cine MRI is a crucial step for early diagnosis and prognosis of CVD, and has been greatly improved with... |
2,330,614 | Optimization of a Thermal Flow Meter for Failure Management of the Shunt in Pediatric Hydrocephalus Patients<sup/>. | Hydrocephalus patients suffer from an abnormal buildup of cerebrospinal fluid (CSF) in their ventricles, and there is currently no known way to cure hydrocephalus. The most prevalent treatment for managing hydrocephalus is to implant a ventriculoperitoneal shunt, which diverts excess CSF out of the brain. However, shun... |
2,330,615 | Long-standing overt ventriculomegaly in adulthood with primary presentation of psychiatric disturbance: A case report. | Hydrocephalus is a common disease in neurosurgery. The typical symptoms of hydrocephalus include urinary incontinence, gait instability, and cognitive decline. Irritability rarely occurs in patients with hydrocephalus. Irritability rarely occurs in patients with hydrocephalus, especially in long-standing overt ventricu... |
2,330,616 | Defining the Spectrum, Treatment and Outcome of Patients With Genetically Confirmed Gorlin Syndrome From the HIT-MED Cohort. | Gorlin syndrome is a genetic condition associated with the occurrence of SHH activated medulloblastoma, basal cell carcinoma, macrocephaly and other congenital anomalies. It is caused by heterozygous pathogenic variants in <i>PTCH1</i> or <i>SUFU</i>. In this study we included 16 patients from the HIT2000, HIT2000inter... |
2,330,617 | Computational Fluid Dynamics Simulations of Mitral Paravalvular Leaks in Human Heart. | In recent years, computational fluid dynamics (CFD) has been extensively used in biomedical research on heart diseases due to its non-invasiveness and relative ease of use in predicting flow patterns inside the cardiovascular system. In this study, a modeling approach involving CFD simulations was employed to study hem... |
2,330,618 | Expression of D5 dopamine receptors in the lateral ventricle walls during post-weaning rat development. | Even before the first synapses appear, neurotransmitters and their receptors are present in the developing brain, regulating the cell fate of neuronal progenitors in neurogenic niches, such as the lateral ventricle. In particular, dopamine appears to play a pivotal role in the neurogenesis of the subventricular zone by... |
2,330,619 | Osteopontin levels are associated with late-time lower regional brain volumes in multiple sclerosis. | Osteopontin (OPN) is a proinflammatory marker produced by systemic immune and central nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal fluid (CSF) and blood is associated with late-time regional brain volumes and white matter (WM) lesion load in MS. Concentrations of OPN in blo... |
2,330,620 | Reference Ranges for Corpus Callosum and Cavum Septi Pellucidi Biometry on Prenatal Ultrasound: Systematic Review and Meta-Analysis. | We conducted a systematic review and meta-analysis of published nomograms for fetal corpus callosum and cavum septi pellucid biometry. A structured literature search was conducted to identify studies that reported normal measurements of the fetal corpus callosum and cavum septi pellucidi. Random effects metaanalysis wa... |
2,330,621 | Effects of a personalized home-based training program among patients suffering from Marfan syndrome: a pilot randomized and controlled study. | Marfan syndrome (MFS) is an autosomal hereditary pathology affecting 1:5000 peoples. Alteration of the fibrillin 1 gene (FBN1) results in haplo-insufficiency of the FBN1 protein mainly altering the vascular system. International recommendations have gradually allowed MFS patients to perform training programs because of... |
2,330,622 | Intracranial hemorrhage in a patient with severe COVID-19 acute respiratory distress syndrome on Veno-venous extra corporeal membrane oxygenation: A case report. | COVID-19 can lead to severe acute respiratory distress syndrome (ARDS) where Veno-Venous Extra Corporeal Membrane Oxygenation (V-V ECMO) may be utilized for patients with severe respiratory failure. Our case report highlights a life threatening complication of V-V ECMO - intracranial hemorrhage (ICH), in a patient bein... |
2,330,623 | Structural MRI profiles and tau correlates of atrophy in autopsy-confirmed CTE. | Chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy, cannot currently be diagnosed during life. Atrophy patterns on magnetic resonance imaging could be an effective in vivo biomarker of CTE, but have not been characterized. Mechanisms of neurodegeneration in CTE are unknown. Here, we characterized mac... |
2,330,624 | Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain. | Little is known about the extent of drug entry into developing brain, when administered to pregnant and lactating women. Lithium is commonly prescribed for bipolar disorder. Here we studied transfer of lithium given to dams, into blood, brain and cerebrospinal fluid (CSF) in embryonic and postnatal animals as well as a... |
2,330,625 | Dual feature correlation guided multi-task learning for Alzheimer's disease prediction. | Alzheimer's disease (AD) is a gradually progressive neurodegenerative disease affecting cognition functions. Predicting the cognitive scores from neuroimage measures and identifying relevant imaging biomarkers are important research topics in the study of AD. Despite machine learning algorithms having many successful a... |
2,330,626 | Guide to the Larval Zebrafish-Aspergillus Infection Model. | The larval zebrafish is an increasingly popular host model for the study of Aspergillosis. The visual accessibility, genetic resources, small size, and ease of handling make zebrafish larvae compatible with higher-throughput investigation of fungal virulence and host resistance mechanisms. This article provides the pro... |
2,330,627 | Toxicity of internalized polyalanine to cells depends on aggregation. | In polyalanine (PA) diseases, the disease-causing transcription factors contain an expansion of alanine repeats. While aggregated proteins that are responsible for the pathogenesis of neurodegenerative disorders show cell-to-cell propagation and thereby exert toxic effects on the recipient cells, whether this is also t... |
2,330,628 | Prediction of severe reflux after oesophageal cancer surgery. | A common and burdensome consequence of oesophagectomy for cancer is reflux. This study aimed to develop a risk prediction model for postoperative reflux using variables available at the time of surgery enabling tailored preventive symptom management.</AbstractText>Data were obtained from a nationwide, population-based ... |
2,330,629 | Rare case report and literature review of intracranial mesenchymal chondrosarcoma. | Intracranial mesenchymal chondrosarcoma (IMC) is a rare primary malignant tumor in the skull, but mostly originates from the abnormal residual chondrocytes in the embryonic period, which grow slowly, and primarily occurs at the junction of the cartilage of the skull base. IMC is difficult to diagnose by preoperative im... |
2,330,630 | Direct left-ventricular global longitudinal strain (GLS) computation with a fully convolutional network. | This study's purpose was to develop a direct MRI-based, deep-learning semantic segmentation approach for computing global longitudinal strain (GLS), a known metric for detecting left-ventricular (LV) cardiotoxicity in breast cancer. Displacement Encoding with Stimulated Echoes cardiac image phases acquired from 30 brea... |
2,330,631 | Severe fetal ventriculomegaly: Fetal morbidity and mortality, caesarean delivery rates and obstetrical challenges in a large prospective cohort. | Severe fetal ventriculomegaly (VM) is defined as an enlargement of the atria of the lateral cerebral ventricles (Vp) of greater than 15 mm. While it is well established that it confers significant risk of morbidity and mortality to the neonate, there is limited information pertaining to the caesarean delivery rate... |
2,330,632 | Clinical Analysis of Risk Factors of Postoperative Psychiatric Disorders in Patients With Adult Craniopharyngioma. | <b>Objective:</b> To analyze the risk factors relative to postoperative psychiatric disorders in adult patients with craniopharyngioma. <b>Methods:</b> A retrospective case-control study design was used in this study. The Neuropsychiatric Inventory-Questionnaire (NPI-Q) assessment tool was used to assess psychiatric di... |
2,330,633 | The Impact of Multimorbidity Burden, Frailty Risk Scoring, and 3-Directional Morphological Indices vs. Testing for CSF Responsiveness in Normal Pressure Hydrocephalus. | <b>Objective:</b> Multimorbidity burden across disease cohorts and variations in clinico-radiographic presentations within normal pressure hydrocephalus (NPH) confound its diagnosis, and the assessment of its amenability to interventions. We hypothesized that novel imaging techniques such as 3-directional linear morpho... |
2,330,634 | Astaxanthin Ameliorates high-fat diet-induced cardiac damage and fibrosis by upregulating and activating SIRT1. | This study evaluated the protective effect of astaxanthin (ASX) against high-fat diet (HFD)-induced cardiac damage and fibrosis in rats and examined if the mechanism of protection involves modulating SIRT1. Rat were divided into 5 groups (n = 10/group) as: 1) control: fed normal diet (3.82 kcal/g), 2) co... |
2,330,635 | Echo planar imaging-induced errors in intracardiac 4D flow MRI quantification. | To assess errors associated with EPI-accelerated intracardiac 4D flow MRI (4DEPI) with EPI factor 5, compared with non-EPI gradient echo (4DGRE).</AbstractText>Three 3T MRI experiments were performed comparing 4DEPI to 4DGRE: steady flow through straight tubes, pulsatile flow in a left-ventricle phantom, and intracardi... |
2,330,636 | A subject-specific assessment of measurement errors and their correction in cerebrospinal fluid velocity maps using 4D flow MRI. | Phase-contrast MRI (PC-MRI) of cerebrospinal fluid (CSF) velocity is used to evaluate the characteristics of intracranial diseases, such as normal-pressure hydrocephalus (NPH). Nevertheless, PC-MRI has several potential error sources, with eddy-current-based phase offset error being non-negligible in CSF measurement. I... |
2,330,637 | Frequency, shape, and estimated volume of intracranial physiologic calcification in different age groups investigated by brain computed tomography scan: a retrospective study. | Intracranial calcification is referred to calcification of parenchyma and vascular structures in brain which can be physiologic or pathologic. This study was conducted with the purpose of investigating the frequency, location, pattern, dimensions and estimated volume of intracranial physiologic calcification (IPC) by c... |
2,330,638 | [Clinical features and CT findings of Takayasu's arteritis associated pulmonary hypertension].<Pagination><StartPage>462</StartPage><EndPage>467</EndPage><MedlinePgn>462-467</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3760/cma.j.cn112147-20200510-00576</ELocationID><Abstract><AbstractText><b>Obje... | <b>Objective:</b> Takayasu's arteritis involving the pulmonary artery (PTA) is uncommon, and those with pulmonary hypertension (PH) are even rarer. This study investigated the clinical features and CT findings in PTA patients with PH. <b>Methods:</b> A total of 40 PTA patients were retrospective selected in the First H... |
2,330,639 | Recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps: A review. | The field of cardiac tissue engineering has advanced over the past decades; however, most research progress has been limited to engineered cardiac tissues (ECTs) at the microscale with minimal geometrical complexities such as 3D strips and patches. Although microscale ECTs are advantageous for drug screening applicatio... |
2,330,640 | Orthogonal external ventricular drain (EVD) trajectory from burr holes sited by junior neurosurgical staff is superior to freehand placement: An in-silico model. | External ventricular drain (EVD) or ventriculostomy placement is one of the most common neurosurgical procedures performed worldwide and is associated with complications including haemorrhage, malposition and infection. Several authors have attempted to define an ideal trajectory for placement, and scalp-mounted guidan... |
2,330,641 | Virtual endoscopy assisted pure ventriculoscopic resection of cavernomas occluding foramen of Monroe: Technical note and literature review. | Cavernomas at Foramen of Monroe (FoM) are rare cases among the intracranial cavernomas. Pure ventriculoscopic removal of cavernoma at FoM through a single burr hole is challenging and rarely reported.</AbstractText>We herein introduced the virtual endoscopy (VE) assisted ventriculoscopic resection to treat the cavernom... |
2,330,642 | Elevated CSF inflammatory markers in patients with idiopathic normal pressure hydrocephalus do not promote NKCC1 hyperactivity in rat choroid plexus. | Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurological condition of unresolved etiology characterized by a clinical triad of symptoms; gait disturbances, urinary incontinence, and cognitive deterioration. In the present study, we aimed to elucidate the molecular coupling between inflam... |
2,330,643 | Capsule-dependent impact of MAPK signalling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis. | The Gram-negative bacterium Neisseria meningitidis (Nm) can cause meningitis in humans, but the host signalling pathways manipulated by Nm during central nervous system (CNS) entry are not completely understood.</AbstractText>We investigate the role of the mitogen-activated protein kinases (MAPK) Erk1/2 and p38 in an i... |
2,330,644 | Outcome of Initial 3 Years of Cranial Endoscopy at DG Khan Medical College and Teaching Hospital, Dera Ghazi Khan. | With the evolution of surgical approaches, endoscopic skull base surgery has emerged as a suitable alternative to many other invasive methods. The aim of this study was to investigate the efficacy and outcome of cranial endoscopy in treating various neurosurgical intracranial pathologies in terms of procedural success ... |
2,330,645 | Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study. | Reduced volumes in brain regions of interest (ROIs), primarily from adult samples, are associated with posttraumatic stress disorder (PTSD). We extended this work to children using data from the Adolescent Brain Cognitive Development (ABCD) Study® (N = 11,848; M<sub>age</sub> = 9.92). S... |
2,330,646 | Fourth Ventricle Dimensions Increase in Chiari Malformation Type 1. | To investigate whether fourth ventricle dimensions and tentorial angulation differ in a healthy control population in our evaluation of patients with CM-1 malformation using MRI.</AbstractText>The radiological and demographic data from 251 patients with CM-1 followed in our clinic between 2014 and 2019 were compared wi... |
2,330,647 | Comparison of Different Endoscopic Techniques for the Treatment of Hydrocephalus in Children. | To present a series of hydrocephalus cases treated with different endoscopic techniques, and to compare their surgical outcomes.</AbstractText>Sixty-one patients underwent endoscopic approach for treating hydrocephalus over a 5-year period. Forty-six patients were children. Three surgical techniques [i.e., endoscopic t... |
2,330,648 | Isolated Lumbar Atypical Choroid Plexus Papilloma: A Case Report. | To report the first case of an isolated lumbar grade II atypical choroid plexus papilloma (CPP).</AbstractText>A 42-year-old man was admitted to the hospital because of back and leg pain. No urinary or rectal dysfunction was detected. Lumbar magnetic resonance imaging (MRI) showed a well-circumscribed, contrast-enhanci... |
2,330,649 | Single-cell RNA sequencing of mouse left ventricle reveals cellular diversity and intercommunication. | Previous studies have revealed the diversity of the whole cardiac cellulome but not refined the left ventricle, which was essential for finding therapeutic targets. Here, we characterized single-cell transcriptional profiles of the mouse left ventricular cellular landscape using single-cell RNA sequencing (10× Gen... |
2,330,650 | Leptomeningeal disease in neurosurgical brain metastases patients: A systematic review and meta-analysis. | Leptomeningeal disease (LMD) is a complication distinguished by progression of metastatic disease into the leptomeninges and subsequent spread via cerebrospinal fluid (CSF). Although treatments for LMD exist, it is considered fatal with a median survival of 2-4 months. A broader overview of the risk factors that increa... |
2,330,651 | The effects of cumulative antipsychotic dose on brain structures in patients with schizophrenia: Observational study of multiple CT scans over a long-term clinical course. | Multiple lines of evidence indicate that antipsychotic agents could affect brain structures of schizophrenia patients. However, the effect of antipsychotic dosage or type on brain structure is uncertain. The present study retrospectively analyzed brain computed tomography (CT) images from a psychiatric hospital to exam... |
2,330,652 | Qualitative and quantitative evaluation of the ventricular system and brain parenchyma in healthy dogs of different skull conformation on computed tomography scans. | This study aimed to perform quantitative and qualitative evaluations of the lateral and third ventricles, and brain parenchyma, in healthy dogs of different skull conformations on CT scans. Forty-five adult client-owned dogs were divided into three groups according to skull conformation: G1 (dolichocephalic)-15 German ... |
2,330,653 | Not all voxels are created equal: Reducing estimation bias in regional NODDI metrics using tissue-weighted means. | Neurite orientation dispersion and density imaging (NODDI) estimates microstructural properties of brain tissue relating to the organisation and processing capacity of neurites, which are essential elements for neuronal communication. Descriptive statistics of NODDI tissue metrics are commonly analyzed in regions-of-in... |
2,330,654 | Longitudinal magnetic resonance evaluation of the schizophrenia model of neonatal lesion in the ventral hippocampus. | To evaluate the progression by means of nuclear magnetic resonance of the lesion in the schizophrenia model of lesion of the ventral hippocampal nucleus (LVNH).</AbstractText>Magnetic resonance imaging (MRI) were performed in male Wistar rats, from 8 days postnatal to 139 days, in animals with LNHV and without lesion (... |
2,330,655 | Quantitative magnetic resonance imaging for segmentation and white matter extraction of the hypothalamus. | Since the hypothalamus is involved in many neuroendocrine, metabolic, and affective disorders, detailed hypothalamic imaging has become of major interest to better characterize disease-induced tissue damages and abnormalities. Still, image contrast of conventional anatomical magnetic resonance imaging lacks morphologic... |
2,330,656 | Cilia locally synthesize proteins to sustain their ultrastructure and functions. | Cilia are microtubule-based hair-like organelles propelling locomotion and extracellular liquid flow or sensing environmental stimuli. As cilia are diffusion barrier-gated subcellular compartments, their protein components are thought to come from the cell body through intraflagellar transport or diffusion. Here we sho... |
2,330,657 | Numerical wave speed sensitivity study for assessment of myocardial elasticity in a simplified linear elastic and isotropic left ventricle model. | Since tissue elasticity can change with pathology, noninvasive assessment of elasticity has received increasing attention. Emerging methods for assessing cardiac elasticity utilize either an external source to induce propagating shear waves or intrinsic longitudinal waves created by natural cardiac events such as left ... |
2,330,658 | Pre- and post-operative cardiovascular CT in Stage I single ventricle palliation. | The aim of this study is to describe clinical utility of low dose cardiac computed tomography (CT) in the evaluation of single ventricle physiology before and after Stage I palliation.</AbstractText>Despite the increased utilization of CT imaging and advancement of CT technology, there are limited studies describing th... |
2,330,659 | Antagonism of the ghrelin receptor type 1a in the rat brain induces status epilepticus in an electrical kindling model of epilepsy. | Studies have shown the anti-seizure properties of the ghrelin hormone in different models of epilepsy. Nevertheless, the role of the endogenous ghrelin is unknown in the electrical kindling model of epilepsy. In this study, we evaluated the effect of the antagonism of the ghrelin receptors in the brain of fully kindled... |
2,330,660 | Predicting neurodevelopmental outcomes in fetuses with isolated mild ventriculomegaly. | Fetal ventriculomegaly is the the most common intracranial abnormality detected antenatally. When ventriculomegaly is mild and the only, isolated, abnormality detected (isolated mild ventriculomegaly (IMVM)) the prognosis is generally considered to be good. We aim to determine if there are features on in utero MRI (iuM... |
2,330,661 | Establishment and validation of prognosis model for patients with cerebral contusion. | Cerebral Contusion (CC) is one of the most serious injury types in patients with traumatic brain injury (TBI). In this study, the baseline data, imaging features and laboratory examinations of patients with CC were summarized and analyzed to develop and validate a prediction model of nomogram to evaluate the clinical o... |
2,330,662 | Brain copper clearance by the blood-cerebrospinal fluid-barrier: Effects of lead exposure. | Lead (Pb) is a heavy metal commonly found in the environment and is known to have neurotoxic, hematological, and other toxic effects. It has been reported that Pb exposure can disturb metal regulation in the blood-cerebrospinal fluid-barrier (BCB). Copper (Cu) plays a key role in maintaining normal brain function and c... |
2,330,663 | Direct Removal of Fourth Ventricle Hematoma in Massive Intraventricular Hemorrhage. | Various grading systems and surgical techniques have been developed for the treatment of intraventricular hemorrhage (IVH); however, little attention has been paid to the fourth ventricle hematoma. Nonetheless, hemorrhagic dilation of the fourth ventricle may lead to catastrophic consequences for patients with massive ... |
2,330,664 | Use of Cardiac Contractility Modulation in an Older Patient with Non-Ischemic Dilated Cardiomyopathy: A Case Report. | Cardiac contractility modulation (CCM) is a novel device-based therapy used in patients with HFrEF. CCM therapy is associated with an improvement in exercise tolerance, increased quality of life, reduced HF hospitalizations, and reverse remodelling of the left ventricle in patients with HFrEF. In this case, we report t... |
2,330,665 | Quadriparesis Due to Delayed Tension Pneumoventricle. | Although pneumocephalus is very common after intracranial or spinal surgeries, pneumoventricle is uncommon. Tension pneumoventricle (tPV) occurs when air in the ventricles expands to cause neurological deficits or mass effect. It is usually seen with a combination of a ball-valve defect postoperatively that sucks in ai... |
2,330,666 | [Correlation of fetal ventriculomegaly with copy number variations and pregnancy outcome]. | To assess the correlation of borderline fetal ventriculomegaly with genomic copy number variations (CNVs) and outcome of pregnancy.</AbstractText>For 84 singleton pregnancies diagnosed with VM, chromosomal microarray analysis (CMA) was carried out to detect the CNVs of the fetal genome. Outcome of the pregnancy and neo... |
2,330,667 | Tongmai granules improve rat hippocampal injury by regulating TLR4/MyD88/AP-1 signaling pathway. | Tongmai granules (TMG) is composed of Salvia miltiorrhiza Bge., Radix puerariae Lobata., and Ligusticum chuanxiong hort. TMG is mainly used for ischemic cardiovascular, cerebrovascular diseases, atherosclerosis, coronary heart disease, cerebral infarction and cerebral ischemia. TMG is a kind of traditional compound gra... |
2,330,668 | Association of blood pressure in the first-week of hospitalization and long-term mortality in patients with acute left ventricular myocardial infarction. | Previous studies have shown that optimal blood pressure (BP) control is necessary to outcomes in patients with acute myocardial infarction (AMI). Acute left ventricular MI is a prevalent type of AMI with poor prognosis. We aimed to analyze the associations between BP control in the first 7 days of hospitalization ... |
2,330,669 | Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? | Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Ind... |
2,330,670 | The Anti-Tumoral Potential of Phosphonate Analog of Sulforaphane in Zebrafish Xenograft Model. | Isothiocyanates (ITCs) show strong activity against numerous human tumors. Five structurally diverse ITCs were tested in vivo using the zebrafish embryos 6 and 48 h post-fertilization (hpf). The survival rate, hatching time, and gross morphological changes were assessed 24, 48, and 72 h after treatment with all compoun... |
2,330,671 | Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases. | Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. Gal-3's role in the central nervous system has been less studied than in the immune system. However, recent studies show it exacerbates Alzheimer's disease and is upregulated in a large variety of brain in... |
2,330,672 | Myelin-Independent Therapeutic Potential of Canine Glial-Restricted Progenitors Transplanted in Mouse Model of Dysmyelinating Disease. | Dysfunction of glia contributes to the deterioration of the central nervous system in a wide array of neurological disorders, thus global replacement of glia is very attractive. Human glial-restricted precursors (hGRPs) transplanted intraventricularly into neonatal mice extensively migrated and rescued the lifespan in ... |
2,330,673 | TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization. | Transient receptor potential ankyrin 1 (TRPA1) plays a role in migraine and is proposed as a promising target for migraine therapy. However, TRPA1-induced signaling in migraine pathogenesis is poorly understood. In this study, we explored the hypothesis that Src family kinases (SFKs) transmit TRPA1 signaling in regulat... |
2,330,674 | Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts. | Although the roles of telomeres and oxidative stress in ischaemic cardiomyopathy (ICM) are known, mechanisms of telomere homeostasis and their relationship with oxidative stress are incompletely understood. We performed two RNA-seq analyses (mRNA <i>n</i> = 23; ncRNA <i>n</i> = 30) and protein validation on left ventri... |
2,330,675 | The Interplay between Myocardial Fibrosis, Strain Imaging and Collagen Biomarkers in Adults with Repaired Tetralogy of Fallot. | We sought to assess the interplay between right ventricle (RV) fibrosis, biventricular dysfunction based on global longitudinal strain (GLS) analysis, and biomarkers such as Galectin-3 (Gal-3), procollagen type III (PCIII), and NTproBNP.</AbstractText>We studied 35 adult patients with rToF. All patients underwent a car... |
2,330,676 | Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology. | Hypertension, a common chronic condition, may damage multiple organs, including the kidney, heart, and brain. Thus, it is essential to understand the pathology upon ectopic activation of the molecular pathways involved in mammalian hypertension to develop strategies to manage hypertension. Animal models play a crucial ... |
2,330,677 | Pectins from various sources inhibit galectin-3-related cardiac fibrosis. | A major challenge in cardiology remains in finding a therapy for cardiac fibrosis. Inhibition of galectin-3 with pectins attenuates fibrosis in animal models of heart failure. The purpose of this study is to identify pectins with the strongest galectin-3 inhibitory capacity. We evaluated the in vitro inhibitory capacit... |
2,330,678 | Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans. | The study of brain clearance mechanisms is an active area of research. While we know that the cerebrospinal fluid (CSF) plays a central role in one of the main existing clearance pathways, the exact processes for the secretion of CSF and the removal of waste products from tissue are under debate. CSF is thought to be c... |
2,330,679 | IMMUNOHISTOCHEMICAL CHARACTERIZATION OF HEPATIC NUCLEAR FACTOR 4 ALPHA EXPRESSION IN THE CHOROID PLEXUS OF THE LATERAL AND 4TH VENTRICLES OF ADULT MALE RAT BRAIN. | The aim: This study aims to compare the lateral and fourth ventricles of CPs using hepatocyte nuclear factor 4 alpha (HNF4α), metabolism marker, to evaluate the functional activity of this tissue in two regions.</AbstractText>Materials and methods: Ten adult male albino rats were used to study the histological fe... |
2,330,680 | Expression of cerebellar degeneration-related proteins CDR2 and CDR2L in human and rat brain tissue. | Patients with ovarian cancer and paraneoplastic cerebellar degeneration, a cancer-related immune disorder, often have anti-Yo antibody. Here we studied the distributions of anti-Yo antigens CDR2L and CDR2 in rat and human brain using immunohistochemistry and western blot. CDR2L localized mainly to the Purkinje cells an... |
2,330,681 | Choroid Plexus Tumors in Children: Long-Term Follow-Up of Consecutive Single-Institutional Series of 59 Patients Treated over a Period of 8 Decades (1939-2020). | To present long-term follow-up of a consecutive single-institutional series of patients treated for choroid plexus tumors over 8 decades.</AbstractText>From 1939 to 2020, 59 children were treated for choroid plexus tumors. Median age at diagnosis was 1.7 years.</AbstractText>Gross total resection was achieved in 51 pat... |
2,330,682 | Prion protein complexed to a DNA aptamer induce behavioral and synapse dysfunction in mice. | Conversion of the cellular prion protein (PrP<sup>C</sup>) into the scrapie form (PrP<sup>Sc</sup>) is the leading step to the development of transmissible spongiform encephalopathies (TSEs), still incurable neurodegenerative disorders. Interaction of PrP<sup>C</sup> with cellular and synthetic ligands that induce form... |
2,330,683 | The posterior interhemispheric transparieto-occipital fissure approach to the atrium of the lateral ventricle: a fiber microdissection study with case series. | The surgical approach to the atrium of the lateral ventricle remains a challenge because of its deep location and close relationship to important neurovascular structures. We present an alternative and safer approach to lesions of the atrium using a natural pathway through the parieto-occipital fissure. We demonstrate ... |
2,330,684 | Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes. | Myocardial infarction causes ventricular muscle loss and formation of scar tissue. The surviving myocardium in the border zone, located adjacent to the infarct, undergoes profound changes in function, structure and composition. How and to what extent these changes of border zone cardiomyocytes are regulated epigenetica... |
2,330,685 | [An improved method for isolation and culture of primary cardiomyocytes from SD neonatal rats]. | <b>Objective:</b> To establish a stable, rapid and improved method for isolation and culture of primary cardiomyocytes from neonatal rats. <b>Methods:</b> Ventricular tissues from neonatal SD rats were digested with 0.12% collagenase Ⅱ, and then subjected to Percoll density gradient centrifugation. The original ... |
2,330,686 | Isolation, culture, and immunostaining of neonatal rat ventricular myocytes. | Isolation and culture of ventricular cardiomyocytes from neonatal rats (NRVMs) is a powerful model to study neonatal cardiac development, cell cycle regulation, and cardiac physiology and pathology <i>in vitro</i>. Here, we present our modified enzymatic digestion protocol followed by two-step discontinuous Percoll gra... |
2,330,687 | Anterograde venous bullet embolism from the left facial vein to the right ventricle. | A young man presented to the emergency department reporting he had been recently shot in the face and chest with an unknown weapon. Initial physical examination only found bruising by the left hemimandible, but CT angiography of the thorax revealed a BB in the right ventricle. A subsequent CT angiography of the head an... |
2,330,688 | Acupuncture for treating symptoms associated with chorea-acanthocytosis: A CARE-compliant case report. | Chorea-acanthocytosis (ChAc) is the most common type of neuroacanthocytosis syndromes. Characteristic movement disorders of ChAc are choreiform movements affecting both trunk and extremities. Acanthocytosis in peripheral blood smear, elevated serum creatine kinase, atrophy of heads of caudate nuclei and dilation of the... |
2,330,689 | Medical image segmentation with generative adversarial semi-supervised network. | Recent medical image segmentation methods heavily rely on large-scale training data and high-quality annotations. However, these resources are hard to obtain due to the limitation of medical images and professional annotators. How to utilize limited annotations and maintain the performance is an essential yet challengi... |
2,330,690 | Microscopic focus on ependymal cells of the spinal cord of the one-humped camel (Camelus dromedarius): Histological, immunohistochemical, and transmission microscopic study. | The current study was designed to give a complete microscopic description of the ependymal cells of the one-humped camel (Camelus dromedarius) using histological, immunohistochemical, and transmission microscopic descriptions of the ependymal cells of the fresh 35 spinal cord samples immediately after their slaughterin... |
2,330,691 | The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation. | Hypoxia is involved in the regulation of various cell functions in the body, including the regulation of stem cells. The hypoxic microenvironment is indispensable from embryonic development to the regeneration and repair of adult cells. In addition to embryonic stem cells, which need to maintain their self-renewal prop... |
2,330,692 | Abdominal Pseudocyst: A Rare Complication of Ventriculoperitoneal Shunts. | We present the case of a 69-year-old man patient who was brought with a history of gait disturbances, memory impairment, and urinary incontinence with gradual worsening over the past six months. The patient underwent magnetic resonance imaging of the brain which demonstrated enlarged ventricles, widening of the Sylvian... |
2,330,693 | Direct effect of RFRP-3 microinjection into the lateral ventricle on the hypothalamic kisspeptin neurons in ovariectomized estrogen-primed rats. | RFamide-related peptide-3 (RFRP-3) may be involved in the inhibition of kisspeptin, but there is no direct evidence that RFRP-3 can directly act on kisspeptin neurons. The present study aimed to investigate the role and mechanism of RFRP-3 and kisspeptin in the hypothalamic-pituitary reproductive axis. In order to dete... |
2,330,694 | Loss of RNA-Binding Protein HuR Leads to Defective Ependymal Cells and Hydrocephalus. | Multiciliated ependymal cells line the ventricle wall and generate CSF flow through ciliary beating. Defects in ependymal cells cause hydrocephalus; however, there are still significant gaps in our understanding the molecular, cellular and developmental mechanisms involved in the pathogenesis of hydrocephalus. Here, we... |
2,330,695 | Comparative anatomy of dissected optic lobes, optic ventricles, midbrain tectum, collicular ventricles, and aqueduct: evolutionary modifications as potential explanation for non-tumoral aqueductal anomalies in humans. | An extensive literature has postulated multiple etiologies for aqueductal stenosis. No publications were found, discussing that evolutionary modifications might explain aqueductal anomalies. This study's objectives were to review the evolutionary modifications of vertebrates' tectum structures that might explain human ... |
2,330,696 | A historical appraisal of the techniques of left ventricular volume reduction in ischemic cardiomyopathy: Who did what? | Resection or exclusion of scars following a myocardial infarction on the left anterior descending artery territory started even before the beginning of the modern era of cardiac surgery. Many techniques were developed, but there is still confusion on who did what. The original techniques underwent modifications that br... |
2,330,697 | The effects of altered neurogenic microRNA levels and their involvement in the aggressiveness of periventricular glioblastoma. | Glioblastoma multiforme is the most common primary brain tumour, with the least favourable prognosis. Despite numerous studies and medical advances, it continues to be lethal, with an average life expectancy of 15 months after chemo-radiotherapy.</AbstractText>Recent research has addressed several factors associated wi... |
2,330,698 | Non-contrast enhanced magnetic resonance imaging for characterization of Fontan associated liver disease. | To evaluate the ability of non-contrast enhanced magnetic resonance imaging (MRI) techniques to characterize Fontan associated liver disease (FALD) in adolescent and adult Fontan patients.</AbstractText>Fontan patients (n = 29) and healthy controls (n = 13) underwent an MRI protocol with T1</sub>, T... |
2,330,699 | Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide. | Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify asso... |
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