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2,331,400 | Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias. | The inherited mutation (R14del) in the calcium regulatory protein phospholamban (PLN) is linked to malignant ventricular arrhythmia with poor prognosis starting at adolescence. However, the underlying early mechanisms that may serve as prognostic factors remain elusive. This study generated humanized mice in which the ... |
2,331,401 | Caloric Restriction and Hypothalamic Leptin Gene Therapy Have Differential Effects on Energy Partitioning in Adult Female Rats. | Dieting is a common but often ineffective long-term strategy for preventing weight gain. Similar to humans, adult rats exhibit progressive weight gain. The adipokine leptin regulates appetite and energy expenditure but hyperleptinemia is associated with leptin resistance. Here, we compared the effects of increasing lep... |
2,331,402 | The Right Ventricle in COVID-19. | Infection with the novel severe acute respiratory coronavirus-2 (SARS-CoV2) results in COVID-19, a disease primarily affecting the respiratory system to provoke a spectrum of clinical manifestations, the most severe being acute respiratory distress syndrome (ARDS). A significant proportion of COVID-19 patients also dev... |
2,331,403 | Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model. | Preclinical drug development studies rarely consider the impact of a candidate drug on established metastatic disease. This may explain why agents that are successful in subcutaneous and even orthotopic preclinical models often fail to demonstrate efficacy in clinical trials. It is reasonable to anticipate that sites o... |
2,331,404 | Tenorio syndrome: Description of 14 novel cases and review of the clinical and molecular features. | Tenorio syndrome (TNORS) (OMIM #616260) is a relatively recent disorder with very few cases described so far. Clinical features included macrocephaly, intellectual disability, hypotonia, enlarged ventricles and autoimmune diseases. Molecular underlying mechanism demonstrated missense variants and a large deletion encom... |
2,331,405 | Cardiocutaneous fistula secondary to left ventricular pseudo-aneurysm rupture. | Cardiocutaneous fistula (CF) is a potentially serious and catastrophic complication. Infection the suture line after left ventricular aneurysm repair, presenting with the CF. We present an unusual case of CF due to staphylococcus infection 6 months after repair of a myocardial rupture secondary to dehiscence ... |
2,331,406 | Multimodal Simulation of a Novel Device for a Safe and Effective External Ventricular Drain Placement. | External ventricular drain (EVD) placement is mandatory for several pathologies. The misplacement rate of the EVD varies widely in literature, ranging from 12.3 to 60%. The purpose of this simulation study is to provide preliminary data about the possibility of increasing the safety of one of the most common life-savin... |
2,331,407 | [Penetrating Right Ventricular Injury by Suicide Attempt:Report of a Case]. | Penetrating heart injury is rare in Japan. A 35-year-old man stabbed himself with a fruit knife that was about 10 cm in length on the left precordium in an attempt to commit suicide and was transferred to our hospital. His vital signs were stable, and the knife remained stabbed in the left precordium. Cardiac injury an... |
2,331,408 | Evaluation of prenatal changes in fetal cardiac morphology and function in maternal diabetes mellitus using a novel fetal speckle-tracking analysis: a prospective cohort study. | Due to metabolic changes in the second trimester and the increasing number of pregnant women with obesity and advanced maternal age, the incidence of gestational diabetes mellitus (GDM) remains high. This study aimed to evaluate the effects of GDM on fetal cardiac morphology and function, and to determine whether these... |
2,331,409 | Combined microsurgical-endoscopic paramedian supracerebellar-infratentorial approach for resection of a pineal low-grade glioma. | The authors present the case of a 20-year-old male with a history of headaches and blurred vision found to have a pineal mass and chronic hydrocephalus. The patient initially underwent an endoscopic third ventriculostomy and pineal mass biopsy that revealed a low-grade neuroepithelial neoplasm. A microsurgery-endoscope... |
2,331,410 | Retractorless interforniceal approach for microsurgical resection of a papillary tumor of the pineal region: operative video and technical nuances. | In this illustrative video, the authors demonstrate microsurgical resection of a papillary tumor of the pineal region using a retractorless interforniceal approach via the anterior interhemispheric transcallosal route. The tumor presented to the posterior third ventricle occluding the cerebral aqueduct, resulting in ob... |
2,331,411 | Anterior endoscopic transcortical approach to a pineal region cavernous hemangioma. | A 57-year-old female presented with headache and dizziness for 3 months. Preoperative MRI revealed a lesion located at the pineal region and back side of the third ventricle, accompanied by hydrocephalus. The infratentorial supracerebellar approach may cause visuomotor, acousticomotor, and hearing disturbances. With th... |
2,331,412 | Interhemispheric transcallosal transchoroidal approach to a pineal teratoma in a 15-year-old boy. | In this video, the authors present an interhemispheric transcallosal transchoroidal approach to a pineal mass in a 15-year-old boy. He received emergency endoscopic third ventriculostomy (ETV), then an endoscopic biopsy that revealed an immature teratoma. Surgical removal was selected. The mass was located very high in... |
2,331,413 | Cardiac Papillary Fibroelastoma in Left Ventricular Trabeculation as a Potential Cause of Cerebral Infarction: A Case Report. | Cardiac papillary fibroelastoma (CPF) is the second or third most common primary cardiac tumor. Although histologically benign, it can cause serious symptoms depending on its location of occurrence, size, and motility. Herein, we report CPF in the left ventricular trabeculation as a potential cause of cerebral infarcti... |
2,331,414 | Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales. | New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence o... |
2,331,415 | Endoscopic Third Ventriculostomy With "Rescue" Fourth Ventriculocisternostomy: 2-Dimensional Operative Video. | This case of endoscopic third ventriculostomy (ETV) and flexible endoscopy for lysis of fourth ventricle adhesions for obstructive hydrocephalus illustrates a key anatomical variant (anastomosis of posterior communicating arteries) that increases the difficulty of ETV and should be recognized preoperatively. The video ... |
2,331,416 | Neonatal susceptibility to meningitis results from the immaturity of epithelial barriers and gut microbiota. | Neonates are highly susceptible to bacterial meningitis as compared to children and adults. Group B streptococcus (GBS) is a major cause of neonatal meningitis. Neonatal meningitis can result from GBS intestinal colonization and translocation across the intestinal barrier (IB). Here, we show that the immaturity of the ... |
2,331,417 | Accuracy of thin-slice model-based iterative reconstruction designed for brain CT to diagnose acute ischemic stroke in the middle cerebral artery territory: a multicenter study. | Model-based iterative reconstruction (MBIR) yields higher spatial resolution and a lower image noise than conventional reconstruction methods. We hypothesized that thin-slice MBIR designed for brain CT could improve the detectability of acute ischemic stroke in the middle cerebral artery (MCA) territory.</AbstractText>... |
2,331,418 | Case report of a coronary artery-right ventricular fistula following repeat endomyocardial biopsies in a heart transplant patient. | Endomyocardial biopsy (EMB) remains the gold standard for cellular rejection surveillance in heart transplant recipients. Coronary artery fistula formation is a rare late and potentially catastrophic complication of repeated endomyocardial biopsies, without contemporary evidence on incidence or management.</AbstractTex... |
2,331,419 | Successful recovery of central venous catheter fragment from coronary venous sinus and right ventricle: A case report.<Pagination><StartPage>2261</StartPage><EndPage>2265</EndPage><MedlinePgn>2261-2265</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.radcr.2021.03.064</ELocationID><Abstract><Ab... | Catheter fracture with subsequent embolization is a well known but a potentially serious late complication of central venous catheter placement. Central venous catheters are frequently implanted for the purpose of chemotherapy and parenteral nutrition. Most common vein used for the placement of central venous catheter ... |
2,331,420 | A reversible cause of left ventricular dysfunction: Case report and brief review.<Pagination><StartPage>383</StartPage><EndPage>388</EndPage><MedlinePgn>383-388</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.repce.2018.12.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S2174-2049(21)0... | The authors describe a case of a patient admitted to the emergency department with diabetic ketoacidosis. Although there were no symptoms attributable to the cardiovascular system, lab tests revealed elevated troponin I and natriuretic peptides, coupled with repolarization abnormalities on the ECG. The transthoracic ec... |
2,331,421 | Multiphysics Computational Modelling of the Cardiac Ventricles. | Development of cardiac multiphysics models has progressed significantly over the decades and simulations combining multiple physics interactions have become increasingly common. In this review, we summarise the progress in this field focusing on various approaches of integrating ventricular structures. electrophysiolog... |
2,331,422 | MRI Natural History of the Leukodystrophy Vanishing White Matter. | Background In vanishing white matter (VWM), a form of leukodystrophy, earlier onset is associated with faster clinical progression. MRI typically shows rarefaction and cystic destruction of the cerebral white matter. Information on the evolution of VWM according to age at onset is lacking. Purpose To determine whether ... |
2,331,423 | Treatment Outcome of Hydrocephalus Associated with Vestibular Schwannoma. | Managing hydrocephalus in patients with vestibular schwannoma (VS) is controversial. We evaluated the clinical factors associated with hydrocephalus.</AbstractText>Between 2000 and 2019, 562 patients with VS were treated at our institute. We applied endoscopic third ventriculostomy (ETV), external ventricular drainage ... |
2,331,424 | Localization of fibroblast growth factor 23 protein in the rat hypothalamus. | Fibroblast growth factor 23 (FGF23) is an endocrine growth factor and known to play a pivotal role in phosphate homeostasis. Interestingly, several studies point towards a function of FGF23 in the hypothalamus. FGF23 classically activates the FGF receptor 1 in the presence of the co-receptor αKlotho, of both gene... |
2,331,425 | Inversion-recovery MR elastography of the human brain for improved stiffness quantification near fluid-solid boundaries. | In vivo MR elastography (MRE) holds promise as a neuroimaging marker. In cerebral MRE, shear waves are introduced into the brain, which also stimulate vibrations in adjacent CSF, resulting in blurring and biased stiffness values near brain surfaces. We here propose inversion-recovery MRE (IR-MRE) to suppress CSF signal... |
2,331,426 | Extra-axial tentorial medulloblastoma: a rare presentation of a common posterior fossa tumour. | Medulloblastoma is a common paediatric posterior fossa tumour typically presenting as midline intra-axial mass involving the cerebellar vermis and/or roof of fourth ventricle with typical radiological features. These can be extra-axial in extremely rare instances with less than 50 cases reported so far in literature. W... |
2,331,427 | Breaking the barrier: In vitro models to study choroid plexus development. | The choroid plexus is central to normal brain function by secreting cerebrospinal fluid and dynamically regulating its composition throughout development and homoeostasis. Much of our current understanding of this region of the brain comes from studies in animal models. These fundamental studies have shed light on chor... |
2,331,428 | Cardiac mechanical efficiency is preserved in primary cardiac hypertrophy despite impaired mechanical function.<ELocationID EIdType="pii" ValidYN="Y">e202012841</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1085/jgp.202012841</ELocationID><Abstract><AbstractText>Increased heart size is a major risk factor for ... | Increased heart size is a major risk factor for heart failure and premature mortality. Although abnormal heart growth subsequent to hypertension often accompanies disturbances in mechano-energetics and cardiac efficiency, it remains uncertain whether hypertrophy is their primary driver. In this study, we aimed to inves... |
2,331,429 | <i>In silico</i> investigation of pro-arrhythmic effects of azithromycin on the human ventricle. | The macrolide antibiotic azithromycin (AZM) is widely used for respiratory infections and has been suggested to be a possible treatment for the Coronavirus Disease of 2019 (COVID-19). However, AZM-associated QT interval prolongation and arrhythmias have been reported. Integrated mechanistic information on AZM actions o... |
2,331,430 | Sex-Specific Association of Left Ventricular Hypertrophy With Rheumatoid Arthritis. | <b>Objectives:</b> Clinical expression of rheumatoid arthritis (RA) varies by gender, but whether cardiovascular disease (CVD) is gender related in RA is unknown. Left ventricular (LV) hypertrophy (LVH) is a hallmark of CVD in RA patients. We investigated whether the association of LVH with RA is gender driven. <b>Meth... |
2,331,431 | Automatic Segmentation and Cardiac Mechanics Analysis of Evolving Zebrafish Using Deep Learning. | <b>Background:</b> In the study of early cardiac development, it is essential to acquire accurate volume changes of the heart chambers. Although advanced imaging techniques, such as light-sheet fluorescent microscopy (LSFM), provide an accurate procedure for analyzing the heart structure, rapid, and robust segmentation... |
2,331,432 | Solitary Metastasis of Colon Adenocarcinoma Mimicking Colloid Cyst of the Third Ventricle. | Metastatic lesions to the choroid plexus, although far less common than colloid cysts, can present very similarly both symptomatically and radiographically. Choroid plexus metastases are most common in the lateral ventricles, however, when they occur in the third and fourth ventricles they may cause obstructive hy... |
2,331,433 | Imaging Findings of Lipomatous Hypertrophy of the Interventricular Septum: A Case Report. | Primary cardiac tumors are rare. We report a case of lipomatous hypertrophy of the interventricular septum in a healthy, asymptomatic, 16 year old female, diagnosed initially by echocardiogram. Non contrast Computed tomography (CT) and Cardiac magnetic resonance imaging (CMR) were also performed to confirm the d... |
2,331,434 | Ventricle shape analysis using modified WKS for atrophy detection. | Brain ventricle is one of the biomarkers for detecting neurological disorders. Studying the shape of the ventricles will aid in the diagnosis process of atrophy and other CSF-related neurological disorders, as ventricles are filled with CSF. This paper introduces a spectral analysis algorithm based on wave kernel signa... |
2,331,435 | Efficacy and safety of flexible versus rigid endoscopic third ventriculostomy in pediatric and adult populations: a systematic review and meta-analysis. | Endoscopic third ventriculostomy (ETV) is a well-established surgical procedure for hydrocephalus treatment, but there is sparse evidence on the optimal choice between flexible and rigid approaches. A meta-analysis was conducted to compare efficacy and safety profiles of both techniques in pediatrics and adults. A comp... |
2,331,436 | Endoscopic Placement of Fourth Ventricular Catheter Using Seldinger Technique: Description of Technique and Case Series. | Neonatal intraventricular hemorrhage remains a significant source of morbidity in premature and low-weight patients. Approximately 15% of patients who require cerebrospinal fluid shunting develop trapped fourth ventricle (TFV). Surgical treatment presents challenges with short- and long-term complications.</AbstractTex... |
2,331,437 | Fourth ventricle roof angle as a measure of fourth ventricle bowing and a radiographic predictor of brainstem dysfunction in Chiari malformation type I. | Chiari malformation type I (CM-I) is a congenital and developmental abnormality that results in tonsillar descent 5 mm below the foramen magnum. However, this cutoff value has poor specificity as a predictor of clinical severity. Therefore, the authors sought to identify a novel radiographic marker predictive of clinic... |
2,331,438 | Left Ventricular Decompression by Transaortic Catheter Venting in Extracorporeal Membrane Oxygenation. | Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely applied to patients with cardiogenic shock. Left ventricle (LV) decompression is important when LV distension develops with pulmonary edema. The purpose of this study was to present the results of transaortic catheter venting (TACV) performed du... |
2,331,439 | Early and late brain resonance findings of two siblings with Hunter syndrome. | Mucopolysaccharidosis type II (MPS II) is a lysosomal disease caused by deficiency of the enzyme iduronate-2-sulfatase (IDS), linked to the X chromosome, producing a wide spectrum of clinical manifestations.</AbstractText>We present the case of two siblings with MPS II of different paternal origin with the same genetic... |
2,331,440 | Tuberculoma in the Fourth Ventricle: An Unusual Location. | To present a young immunocompetent patient with a fourth ventricle tuberculoma without pulmonary tuberculosis. A previously healthy young male patient presented with a history of headache, nausea, and blurred vision. Neuroimaging revealed a mass present in the fourth ventricle. The lesion was successfully resected. His... |
2,331,441 | Bilateral Lambdoid and Sagittal Craniosynostosis with Hydrocephalus: ETV, Bifrontal Craniotomy, Anterior Cranial Vault Remodeling, and Posterior Cranial Vault Expansion. | Bilateral lambdoid and sagittal craniosynostosis (BLSS), also known as Mercedes Benz pattern craniosynostosis, is a rare form of craniosynostosis. The whole cranial vault remodeling gives the best result.</AbstractText>To describe the role of endoscopic third ventriculostomy (ETV) and whole cranial vault remodeling for... |
2,331,442 | SHAPE-REGULARIZED UNSUPERVISED LEFT VENTRICULAR MOTION NETWORK WITH SEGMENTATION CAPABILITY IN 3D+TIME ECHOCARDIOGRAPHY. | Accurate motion estimation and segmentation of the left ventricle from medical images are important tasks for quantitative evaluation of cardiovascular health. Echocardiography offers a cost-efficient and non-invasive modality for examining the heart, but provides additional challenges for automated analyses due to the... |
2,331,443 | A case of chronic dysaesthesia in the torso and upper limbs: lessons from a cervical spinal cord subependymoma. | Subependymomas are slow growing WHO grade 1 tumours, typically attached to the ventricular wall of the fourth or lateral ventricles. Spinal subependymomas are rarer still and experience of their biological characteristics remains limited.</AbstractText>A 29-year-old lady presented with chronic attacks of itchy dysaesth... |
2,331,444 | Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians: The Strong Heart Study. | <b>Objectives:</b> American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). <b>Methods:</b> We used linear and Poisson ... |
2,331,445 | How I do it: parietal trans-sulcal para-fascicular approach to lateral thalamic/internal capsule cavernous malformation. | The surgical management of deep brain lesions is challenging, with significant morbidity. Advances in surgical technology have presented the opportunity to tackle these lesions.</AbstractText>We performed a complete resection of a thalamic/internal capsule CM using a tubular retractor system via a parietal trans-sulcal... |
2,331,446 | Assessment of Myocardial Dysfunction by Three-Dimensional Echocardiography Combined With Myocardial Contrast Echocardiography in Type 2 Diabetes Mellitus. | <b>Background:</b> We aimed to explore the value of combining real-time three-dimensional echocardiography (RT-3DE) and myocardial contrast echocardiography (MCE) in the left ventricle (LV) evaluating myocardial dysfunction in type 2 diabetes mellitus (T2DM) patients. <b>Patients and Methods:</b> A total of 58 T2DM pat... |
2,331,447 | 1p36 Deletion Syndrome and Left Ventricular Non-compaction Cardiomyopathy-Two Cases Report. | 1p36 deletion is the most common terminal deletion syndrome in humans. Herein, we report two cases, a 5-month-old female and a 14.5-year-old female, both with 1p36 deletion and left ventricular non-compaction cardiomyopathy. They presented with severely depressed left ventricle function and underwent heart transplantat... |
2,331,448 | Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for <i>In Vivo</i> Studies. | The cardiac sodium-calcium exchanger (NCX1) is important for normal Na<sup>+</sup>- and Ca<sup>2+</sup>-homeostasis and cardiomyocyte relaxation and contraction. It has been suggested that NCX1 activity is reduced by phosphorylated phospholemman (pSer68-PLM); however its direct interaction with PLM is debated. Disrupti... |
2,331,449 | The Ependymal Region Prevents Glioblastoma From Penetrating Into the Ventricle via a Nonmechanical Force. | Intraventricular penetration is rare in glioblastoma (GBM). Whether the ependymal region including the ependyma and subventricular zone (SVZ) can prevent GBM invasion remains unclear.</AbstractText>Magnetic resonance imaging (MRI) and haematoxylin-eosin (HE) staining were performed to evaluate the size and anatomical l... |
2,331,450 | Spatiotemporal dynamics of γH2AX in the mouse brain after acute irradiation at different postnatal days with special reference to the dentate gyrus of the hippocampus. | Gamma H2A histone family member X (γH2AX) is a molecular marker of aging and disease. However, radiosensitivity of the different brain cells, including neurons, glial cells, cells in cerebrovascular system, epithelial cells in pia mater, ependymal cells lining the ventricles of the brain in immature animals at di... |
2,331,451 | Cardiac fibroma with cardiac arrest: a rare clinical presentation of Gorlin syndrome in an 8-month-old infant. | Paediatric cardiac tumours are rare, often benign and carry associations with genetic conditions. Cardiac fibromas are mainly composed of fibroblast and connective tissue . They can lead to symptoms due to obstruction of blood flow or arrythmias. In this case, we report an 8-month-old girl child who presented to paedia... |
2,331,452 | Spindle Cell Squamous Cell Carcinoma of the Larynx with Malignant Osteoid Differentiation: A Case Report and Review of Literature. | Spindle cell squamous cell carcinoma of the larynx is a rare, aggressive variant of squamous cell carcinoma. It comprises 0.6-1.5% of all laryngeal cancers. Heterologous mesenchymal differentiation as bone, cartilage, and muscle is uncommon, especially malignant osteoid differentiation, as a handful of cases reported i... |
2,331,453 | Evaluation of the sphericity index of the fetal heart during middle and late pregnancy using fetalHQ. | To explore the feasibility of the fetal heart quantitative technique (fetalHQ) for evaluating the sphericity index (SI) of the fetal heart during middle and late pregnancy.</AbstractText>Ninety-six normal fetuses in middle and late gestation who underwent systemic ultrasound examination in the Department of Ultrasound ... |
2,331,454 | Effects of platelet rich plasma on experimentally induced diabetic heart injury. | Diabetic heart is one of the common complications of diabetes mellitus. Platelet-rich plasma (PRP) is an autologous product rich in growth factors that can enhance tissue regeneration. This work was conducted to study the PRP ability to improve diabetes-inducing cardiac changes. Also, it sheds more light on the possibl... |
2,331,455 | Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation. | Lowered glucose availability, sensed by the hindbrain, has been suggested to enhance gluconeogenesis and food intake as well as suppress reproductive function. In fact, our previous histological and in vitro studies suggest that hindbrain ependymal cells function as a glucose sensor. The present study aimed to clarify ... |
2,331,456 | The Heart of Pediatric Patients with COVID-19: New Insights from a Systematic Echocardiographic Study in a Tertiary Hospital in Brazil. | COVID-19 pandemic represents a huge burden to the health system in the world. Although pediatric COVID-19 patients have been relatively spared compared with adults, recent reports showed an increasing number of critically ill patients with multisystemic inflammatory syndrome in children (MIS-c), with marked cardiovascu... |
2,331,457 | Malignant intraventricular meningioma: literature review and case report. | Malignant intraventricular meningiomas (IVMs) are very rare with only a few reported cases. A midline search up to December 2020 selected 40 articles for a total of 65 patients. The inclusion criteria were series and case reports in English language, as well as papers written in other languages, but with abstracts writ... |
2,331,458 | Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data. | The relaxin peptide signaling system is involved in diverse physiological processes, but its possible roles in the brain, including nociception, are largely unexplored.</AbstractText>In light of abundant expression of relaxin receptor (RXFP1) mRNA/protein in brain regions involved in pain processing, we investigated th... |
2,331,459 | miRNAs generated from Meg3-Mirg locus are downregulated during aging. | Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies. MicroRNAs are recognized as fine tuners of all cellular functions, being involved in various cardiac diseases. The heart is one of the most affected organs in aged individuals, however little is known about the exten... |
2,331,460 | Hidden danger of COVID-19 outbreak: evaluation of subclinical myocardial dysfunction in patients with mild symptoms. | The COVID-19 infection, which is caused by the novel coronavirus SARS-CoV-2, has rapidly emerged as a global public health issue. Cardiac complications secondary to this infection are common and associated with mortality. This study aimed to evaluate whether subclinical myocardial dysfunction exists in non-hospitalized... |
2,331,461 | Dysregulation of brain and choroid plexus cell types in severe COVID-19. | Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of COVID-19 can suffer neurological symptoms<sup>1-3</sup>. However, an unbiased understanding of the cellular and molecular processes that are affected in the brains of patients with COVID-19 is missing. Here we profile 65,309&#x... |
2,331,462 | Glucose fluctuation accelerates cardiac injury of diabetic mice via sodium-dependent glucose cotransporter 1 (SGLT1). | Recent studies have shown that blood glucose fluctuation is associated with complications of diabetes mellitus (DM). SGLT1 (sodium-dependent glucose cotransporter 1), is highly expressed in pathological conditions of heart, and is expressed in cardiomyocytes induced by high glucose. Herein, we constructed a diabetic mo... |
2,331,463 | Hemorrhagic transformation and stroke recurrence in children with cardiac disease receiving antithrombotic therapy for secondary stroke prevention. | Antithrombotic therapy is currently recommended for stroke prevention in pediatric cardioembolic stroke where the recurrence risk is high; however, safety concerns remain. The primary objective of this study was to evaluate clinical and radiographic predictors of hemorrhagic transformation and stroke recurrence in chil... |
2,331,464 | FACS Enrichment of Total Interstitial Cells and Fibroblasts from Adult Mouse Ventricles. | Besides cardiomyocytes, the heart contains numerous interstitial cell types, including cardiac fibroblasts, endothelial cells, immune (myeloid and lymphoid) cells, and mural cells (pericytes and vascular smooth muscle cells), which play key roles in heart repair, regeneration, and disease. We recently published a compr... |
2,331,465 | Magnetic resonance imaging of a third ventricular chordoid glioma. | Chordoid gliomas are uncommon neoplasms located within the anterior portion of the third ventricle. In this article, we aimed to describe the clinical presentation, magnetic resonance imaging characteristics, histological findings, and surgical treatment applied to a case of chordoid glioma. Chordoid gliomas are typica... |
2,331,466 | Influence of Fibrosis Amount and Patterns on Ventricular Arrhythmogenesis and Pumping Efficacy: Computational Study. | Myocardial fibrosis is an integral component of most forms of heart failure. Clinical and computational studies have reported that spatial fibrosis pattern and fibrosis amount play a significant role in ventricular arrhythmogenicity. This study investigated the effect of the spatial distribution of fibrosis and fibrosi... |
2,331,467 | Left Ventricular Pressure Ratio Predicts In-Hospital Outcomes in Hospitalized Heart Failure With Reduced Ejection Fraction.<Pagination><StartPage>E507</StartPage><EndPage>E515</EndPage><MedlinePgn>E507-E515</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">JIC20210616-1</ELocationID><Abstract><AbstractTex... | Remote intracranial hemorrhage (ICH) is a rare but dreaded complication after spinal surgery. The physiopathology of this phenomenon is closely related to a loss of cerebrospinal fluid (CSF) after an incidental durotomy during spine surgery. The most common remote ICH location is cerebellar, but few articles report int... |
2,331,468 | Customising the surgical management for intraventricular meningiomas - 'one size doesn't fit all'. | Intraventricular meningiomas are uncommon and gross total resection is the recommended treatment. However, total resection may not always be possible, especially in locations in which the lesions are adherent to veins and neural structures. We share our experience with intraventricular meningiomas, focusing on the mana... |
2,331,469 | Implantation of Carmustine wafers after resection of malignant glioma with and without opening of the ventricular system. | Implantation of biodegradable Carmustine wafers in patients with malignant glioma is not generally recommended when the ventricular system is opened during tumor resection. Thrombin/fibrinogenn-covered collagen fleeces showed promising results in sufficiently closing ventricular defects. The aim of this study was to ev... |
2,331,470 | Ependymoma Presenting as a -Rim-Enhancing Lesion in the Brainstem. | The posterior fossa is the most common intracranial location for pediatric ependymoma. While ependymoma usually arises from the ventricular lining of the fourth ventricle as a solid mass, it rarely originates from the brainstem. Grade II ependymomas also infrequently appear as a cavitary ring-enhancing lesion.</Abstrac... |
2,331,471 | Quadrigeminal Cistern Epidermoid Cyst: Neuroendoscopy and Endoscope-Assisted Supracerebellar Infratentorial Approach. | The pineal region is a complex anatomical location with multiple surrounding important neurovascular structures.<sup>1</sup><sup>,</sup><sup>2</sup> Several approaches to this region have been described, including posterior interhemispheric, transchoroidal, infratentorial supracerebellar, supracerebellar and infracereb... |
2,331,472 | Brain ventricular volume changes in schizophrenia. A narrative review. | Brain ventricles are among the most studied structures in psychotic illness. In our mini-review we present available evidence on brain ventricle changes during the course of schizophrenia, from high-risk subjects and the first episode of schizophrenia to patients with chronic schizophrenia. We present current findings ... |
2,331,473 | Automatic left ventricular cavity segmentation via deep spatial sequential network in 4D computed tomography. | Automated segmentation of left ventricular cavity (LVC) in temporal cardiac image sequences (consisting of multiple time-points) is a fundamental requirement for quantitative analysis of cardiac structural and functional changes. Deep learning methods for segmentation are the state-of-the-art in performance; however, t... |
2,331,474 | Identification to cardiac conduction cells in humans and pigs according to their zonal distribution, using histological, immunohistochemical and morphometric study. | Histologically, the cardiac conduction network is formed of electrically isolated subendocardial fibers that comprise specialized cells with fewer myofibrils and mitochondria than cardiomyocytes. Our aim is to uncover regional variations of cardiac conduction fibers through histological and morphometric study in a porc... |
2,331,475 | Massa intermedia of the thalamus: an anatomical study using magnetic resonance imaging. | Few studies have explored the morphology of massa intermedia (MI). The aim of the present study was to characterize it using magnetic resonance imaging (MRI).</AbstractText>A total of 205 patients were enrolled in this study. Following initial examinations with conventional MRI sequences, thin-slice coronal and sagitta... |
2,331,476 | Deep learning prediction of mild cognitive impairment conversion to Alzheimer's disease at 3 years after diagnosis using longitudinal and whole-brain 3D MRI. | While there is no cure for Alzheimer's disease (AD), early diagnosis and accurate prognosis of AD may enable or encourage lifestyle changes, neurocognitive enrichment, and interventions to slow the rate of cognitive decline. The goal of our study was to develop and evaluate a novel deep learning algorithm to predict mi... |
2,331,477 | Asymptomatic traumatic rupture of an intracranial dermoid cyst: A case report. | Previous studies reported that most of the intracranial dermoid cyst ruptures were spontaneous, and only a few were traumatic, with asymptomatic much rarer than the symptomatic ruptures. Hence, how to deal with the asymptomatic traumatic rupture of intracranial dermoid cyst remains a challenge in the clinic.</AbstractT... |
2,331,478 | Sex Differences in Cardiac Adaptation to Distinct Modalities of Exercise: A Cardiac Magnetic Resonance Study.<Pagination><StartPage>2543</StartPage><EndPage>2552</EndPage><MedlinePgn>2543-2552</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1249/MSS.0000000000002729</ELocationID><Abstract><AbstractTe... | No previous study has described sex differences in chronic cardiac adaptation in response to distinct modalities of exercise training in humans.</AbstractText>Cardiac magnetic resonance imaging (1.5 T) was used to assess left ventricular (LV) outcomes in 78 untrained subjects (46F, 26 M; 26.1 ± 5.4 yr). Subjects u... |
2,331,479 | Early Myocardial Dysfunction and Benefits of Cardiac Treatment in Young X-Linked Duchenne Muscular Dystrophy Mice. | Duchenne muscular dystrophy (DMD) is associated with a progressive alteration in cardiac function.</AbstractText>The aim of this study was to detect early cardiac dysfunction using the high sensitive two-dimensional speckle-tracking echocardiography (2D strain) in mdx mouse model and to investigate the potential preven... |
2,331,480 | Induction of autophagy has protective roles in imatinib-induced cardiotoxicity. | Cardiotoxicity is one of the severe adverse effects of chemotherapeutic agents. Imatinib was previously reported to induce cardiotoxicity. Autophagy is an intracellular bulk protein and organelle degradation process, but its roles in cardiac diseases are unclear. We examined whether imatinib induces cardiomyocyte autop... |
2,331,481 | Physiological Effects of Intermittent Passive Exposure to Hypobaric Hypoxia and Cold in Rats. | The benefits of intermittent hypobaric hypoxia (IHH) exposure for health and its potential use as a training tool are well-documented. However, since hypobaric hypoxia and cold are environmental factors always strongly associated in the biosphere, additive or synergistic adaptations could have evolved in animals' genom... |
2,331,482 | Radiomics side experiments and DAFIT approach in identifying pulmonary hypertension using Cardiac MRI derived radiomics based machine learning models. | Side experiments are performed on radiomics models to improve their reproducibility. We measure the impact of myocardial masks, radiomic side experiments and data augmentation for information transfer (DAFIT) approach to differentiate patients with and without pulmonary hypertension (PH) using cardiac MRI (CMRI) derive... |
2,331,483 | [DJ-1 alleviates oxidative stress injury by activating the Nrf2 pathway in rats with cerebral ischemia-reperfusion injury]. | To investigate the antioxidant effect of DJ-1 (Park7) in rats with cerebral ischemia/reperfusion (IR) injury and its potential mechanism.</AbstractText>A total of 108 SD rats were randomly divided into sham-operated group, middle cerebral artery occlusion (MCAO) group, Scramble group, DJ-1 siRNA group, negative control... |
2,331,484 | Chordoid glioma in the thalamus of a child: Rare location and atypical imaging findings. | Chordoid glioma is a rare intracranial tumour, which usually occurs in middle-aged female patients, mainly in the third ventricle, hypothalamus and suprasellar region. It can reportedly occur in the temporal-parietal lobe, occipital horn of the lateral ventricle and left thalamus. Here, we report a case of chordoid gli... |
2,331,485 | Freshly Thawed Cryobanked Human Neural Stem Cells Engraft within Endogenous Neurogenic Niches and Restore Cognitive Function after Chronic Traumatic Brain Injury. | Human neural stem cells (hNSCs) have potential as a cell therapy after traumatic brain injury (TBI). While various studies have demonstrated the efficacy of NSCs from ongoing culture, there is a significant gap in our understanding of freshly thawed cells from cryobanked stocks-a more clinically relevant source. To add... |
2,331,486 | Basement Membrane Extracellular Matrix Proteins in Pulmonary Vascular and Right Ventricular Remodeling in Pulmonary Hypertension. | The extracellular matrix (ECM), a highly organized network of structural and nonstructural proteins, plays a pivotal role in cellular and tissue homeostasis. Changes in the ECM are critical for normal tissue repair, whereas dysregulation contributes to aberrant tissue remodeling. Pulmonary arterial hypertension is a se... |
2,331,487 | Neurosurgical anatomy of the floor of the third ventricle and related vascular structures. | Anatomical knowledge of the floor of the third ventricle (FTV) is essential in avoiding surgical complications during endoscopic third ventriculostomy. The purpose of this study was to characterize the morphometry of FTV and related arteries, particularly the basilar artery (BA), as well as the factors that influence i... |
2,331,488 | The impact of real-time fMRI denoising on online evaluation of brain activity and functional connectivity. | <i>Objective</i>. Comprehensive denoising is imperative in functional magnetic resonance imaging (fMRI) analysis to reliably evaluate neural activity from the blood oxygenation level dependent signal. In real-time fMRI, however, only a minimal denoising process has been applied and the impact of insufficient denoising ... |
2,331,489 | Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma. | Central nervous system (CNS) germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus (BGTGs) have proven challenging to treat giv... |
2,331,490 | Cardiac Abnormalities in COVID-19 Patients: Should a Cardiac Echocardiogram be Routine? | Current scientific evidence shows that SARS-CoV-2 infection is associated with an increased risk of thromboembolic events. In patients with ischaemic heart disease and heart failure, thrombi of the left ventricle can increase patient mortality, mainly due to the risk of systemic embolization. Given the hypercoagulable ... |
2,331,491 | Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension. | Pulmonary arterial hypertension (PAH) is a disease resulting in increased right ventricular (RV) afterload and RV remodeling. PAH results in altered RV structure and function at different scales from organ-level hemodynamics to tissue-level biomechanical properties, fiber-level architecture, and cardiomyocyte-level con... |
2,331,492 | Cerebrospinal Fluid Leaks From the Lateral Ventricle: A Case Series. | Describe the diagnosis and management of lateral skull base (LSB) cerebrospinal fluid (CSF) leaks originating from the lateral ventricle.</AbstractText>Retrospective case review.</AbstractText>Tertiary referral academic center.</AbstractText>Patients with CSF leaks with direct communication to the lateral ventricle on ... |
2,331,493 | Segmented Linear Mixed Model Analysis Reveals Association of the APOEɛ4 Allele with Faster Rate of Alzheimer's Disease Dementia Progression. | APOEɛ4 allele carriers present with an increased risk for late-onset Alzheimer's disease (AD), show cognitive symptoms at an earlier age, and are more likely to transition from mild cognitive impairment (MCI) to dementia but despite this, it remains unclear whether or not the ɛ4 allele controls the rate of ... |
2,331,494 | Choroid plexus epithelial cells as a model to study nongenomic steroid signaling and its effect on ion channel function. | The choroid plexus (CP) is an epithelial tissue primarily responsible for the secretion of the cerebrospinal fluid (CSF). Choroid plexuses are found in each of the four brain ventricles: two laterals, third and fourth. They ensure continuous production of CSF to provide nutrients, remove waste products and provide a me... |
2,331,495 | Regional adiposity, cardiorespiratory fitness, and left ventricular strain: an analysis from the Dallas Heart Study. | Low cardiorespiratory fitness (CRF), high body mass index, and excess visceral adiposity are each associated with impairment in left ventricular (LV) peak circumferential strain (Ecc</sub>), an intermediate phenotype that precedes the development of clinical heart failure (HF). However, the association of regional... |
2,331,496 | Clinical features, diagnosis, and survival analysis of dogs with glioma. | Gliomas in dogs remain poorly understood.</AbstractText>To characterize the clinicopathologic findings, diagnostic imaging features and survival of a large sample of dogs with glioma using the Comparative Brain Tumor Consortium diagnostic classification.</AbstractText>Ninety-one dogs with histopathological diagnosis of... |
2,331,497 | Distribution and morphology of ventricular bands in the hearts of ringed seals. | In contrast to studies on domestic animals, few reports describe ventricular bands in wildlife, and none in aquatic mammals. Ventricular bands in the endangered Saimaa ringed seal (Pusa hispida saimensis) and the Baltic ringed seal (Pusa hispida botnica) were examined as part of an ongoing research on the comparative a... |
2,331,498 | Left ventricle motion estimation for cine MR images using sparse representation with shape constraint. | To propose a left ventricle (LV) motion estimation method based on sparse representation, in order to handle the spatial-varying intensity distortions caused by tissue deformation.</AbstractText>For each myocardial landmark, an adaptive dictionary was generated by learning transformations from a training dataset. Then ... |
2,331,499 | Combining stem cells in myocardial infarction: The road to superior repair? | Myocardial infarction irreversibly destroys millions of cardiomyocytes in the ventricle, making it the leading cause of heart failure worldwide. Over the past two decades, many progenitor and stem cell types were proposed as the ideal candidate to regenerate the heart after injury. The potential of stem cell therapy ha... |
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