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2,332,900 | In vivo implantation of 2,2'-bis(oxazoline)-linked poly-epsilon-caprolactone: proof for enzyme sensitive surface erosion and biocompatibility. | Previously, we have demonstrated that 2,2-bis(2-oxazoline) linked poly-epsilon-caprolactone (PCL-O) is degraded in vitro enzymatically by surface erosion which could enable the novel use of this material for drug delivery and other biomedical applications. In this study, degradation, erosion (weight loss) and toxicity ... |
2,332,901 | Pharmacokinetics, pharmacodynamics, and tolerability of the dipeptidyl peptidase IV inhibitor LC15-0444 in healthy Korean men: a dose-block-randomized, double-blind, placebo-controlled, ascending single-dose, Phase I study. | LC15-0444 is a selective inhibitor of dipeptidyl peptidase (DPP) IV under investigation in Korea for the treatment of type 2 diabetes.</AbstractText>The aim of this study was to investigate the pharmacokinetic (PK), pharmacodynamic (PD), and tolerability profiles of a single dose of LC15-0444 in healthy male subjects.<... |
2,332,902 | Urbanization and coronary heart disease: a study of urban-rural differences in northern India. | In the West, urbanization has been accompanied by a rise in the rate of coronary heart disease. This trend has gone hand in hand with an increased consumption of processed, energy-dense food and dependence on machines for physical work. To examine whether a similar trend is underway in northern India, the prevalence of... |
2,332,903 | Midazolam with bupivacaine for improving analgesia quality in brachial plexus block for upper limb surgeries. | To compare the onset, duration and postoperative pain scores of supraclavicular block with bupivacaine alone and bupivacaine-midazolam combination.</AbstractText>Randomized controlled clinical trial.</AbstractText>The Postgraduate Medical Institute, Hayatabad Medical Complex, Peshawar, from April 2005 to June 2007.</Ab... |
2,332,904 | Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen. | Nitric oxide (NO) inhibits platelet adhesion to collagen, although the precise molecular mechanisms underlying this process are unclear.</AbstractText>Collagen-mediated adhesion is a multifaceted event requiring multiple receptors and platelet-derived soluble agonists. We investigated the influence of NO on these proce... |
2,332,905 | Expression of cardiac alpha-actin spares extraocular muscles in skeletal muscle alpha-actin diseases--quantification of striated alpha-actins by MRM-mass spectrometry. | As with many skeletal muscle diseases, the extraocular muscles (EOMs) are spared in skeletal muscle alpha-actin diseases, with no ophthalmoplegia even in severely affected patients. We hypothesised that the extraocular muscles sparing in these patients was due to significant expression of cardiac alpha-actin, the alpha... |
2,332,906 | Superficial versus combined (deep and superficial) cervical plexus block for carotid endarterectomy. | It is not clear if any technique of regional anesthesia for carotid endarterectomy has an advantage over another. Therefore, we analyzed analgesic efficacy side effects and complication rate in patients undergoing carotid surgery either under combined (deep and superficial) or superficial cervical block alone. Data on ... |
2,332,907 | Red blood cell accumulation in a rat model of pulmonary ischemia/reperfusion injury. | Red blood cell (RBC) accumulation in lung tissue during ischemia/reperfusion has not been studied extensively. A warm lung ischemia/reperfusion-injury model was developed to determine RBC trapping.</AbstractText>Twenty-four rats were randomized into 5 groups. In 4 groups, the left lung was submitted to 20 minutes of wa... |
2,332,908 | Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. | Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate se... |
2,332,909 | Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer. | The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated cellular binding and ... |
2,332,910 | Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model. | In the situation that it would not be able to produce model animals for mitochondrial diseases caused by mitochondrial DNA (mtDNA) with pathogenic mutations, we succeeded in generating mice with pathogenic deletion mutant mtDNA (DeltamtDNA), named "mito-mice", by direct introduction of mitochondria with DeltamtDNA into... |
2,332,911 | Clinical pharmacology of cisatracurium during nitrous oxide-propofol anesthesia in children. | To describe, in pediatric patients, the effects of three doses of cisatracurium during nitrous oxide-propofol anesthesia and to determine if larger doses result in faster onset time.</AbstractText>College hospital.</AbstractText>75 ASA physical status I and II children, aged 15 to 60 months, undergoing surgery for hypo... |
2,332,912 | Priming donor lungs with thioredoxin-1 attenuates acute allograft injury in a rat model of lung transplantation. | Lung graft dysfunction and rejection are significant causes of morbidity and mortality in transplant recipients. Thioredoxin-1, a redox-regulatory protein, functions as an antioxidant in multiple organs, including lungs. We examined whether priming of the donor lungs with thioredoxin-1 before transplantation attenuates... |
2,332,913 | [Clinical and genetic analysis of a pedigree of myotonic dystrophy disease]. | To investigate the clinical manifestations and to make genetic analysis in a pedigree with myotonic dystrophy disease.</AbstractText>The proband and available family members were identified by neurological examination. The clinical manifestation of 8 patients (including the proband) was analyzed; the electromyographic ... |
2,332,914 | The physiological effects of thoracic epidural anesthesia and analgesia on the cardiovascular, respiratory and gastrointestinal systems. | Studies of regional anesthesia are increasing in popularity not only for the purpose of technical advancement, but also to better understand the effects of neural deafferentation on the function of various organs. Thoracic epidural anesthesia (TEA) is one of the most versatile and widely utilized neural deafferentation... |
2,332,915 | Surgical stress index as a measure of nociception/antinociception balance during general anesthesia. | No validated monitoring method is available for evaluating the nociception/antinociception balance. We assessed the surgical stress index (SSI), computed from finger photoplethysmographic waveform amplitudes and pulse-to-pulse intervals, in patients undergoing shoulder surgery under general anesthesia (GA) and intersca... |
2,332,916 | Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes. | Cardiac voltage-gated sodium channels control action potential (AP) upstroke and cell excitability. Intracellular calcium (Ca(i)(2+)) regulates AP properties by modulating various ion channels. Whether Ca(i)(2+) modulates sodium channels in ventricular myocytes is unresolved. We studied whether Ca(i)(2+) modulates sodi... |
2,332,917 | A comparison of paracervical block with single-shot spinal for labour analgesia in multiparous women: a randomised controlled trial. | Epidural and spinal analgesia may be contraindicated or unavailable in labour. This randomised controlled study examined the suitability of paracervical block as an alternative method of labour analgesia.</AbstractText>Multiparous women in labour were randomised to receive either paracervical block or single-shot spina... |
2,332,918 | Influence of Home Monitoring on the clinical status of heart failure patients: Design and rationale of the IN-TIME study. | Despite optimal drug and device therapy, frequent hospitalisations due to decompensated heart failure remain an issue. Early detection of decompensation could prevent hospitalisation in patients with congestive heart failure. The recently introduced Home Monitoring functionality of implanted devices is a promising new ... |
2,332,919 | [Diagnostics of autoimmune diseases]. | Autoantibodies play a key role in diagnostic laboratories as markers of autoimmune diseases. In addition to their role as markers they mediate diverse effects in vivo. Autoantibodies with protective effect have been described. Natural protective IgM autoantibodies against tumour-antigens of malignant cells or their pre... |
2,332,920 | Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity. | KCNQ1-5 (Kv7.1-7.5) subunits assemble to form a variety of functional K(+) channels in the nervous system, heart, and epithelia. KCNQ1 and KCNQ4 homomers and KCNQ2/3 heteromers yield large currents, whereas KCNQ2 and KCNQ3 homomers yield small currents. Since the unitary conductance of KCNQ3 is five- to 10-fold greater... |
2,332,921 | PPADS does not block contraction-induced prostaglandin E2 synthesis in cat skeletal muscle. | Pyridoxal-phosphate-6-azophenyl-2'-4-disulfonate (PPADS), a purinergic 2 (P2) receptor antagonist, has been shown to attenuate the exercise pressor reflex in cats. In vitro, however, PPADS has been shown to block the production of prostaglandins, some of which play a role in evoking the exercise pressor reflex. Thus th... |
2,332,922 | Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. | Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na(+) channels. However, it remains unknown whether it has any effects on K(+) currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular ... |
2,332,923 | Perspectives on interactions between antiepileptic drugs (AEDs) and antimicrobial agents. | In the treatment of seizures and epilepsy associated with central nervous system (CNS) infections, drug-drug interactions may significantly and unexpectedly impact outcome not only of epilepsy but also of the infectious disorders in both emergent and chronic care situations. A case is described in whom, the administrat... |
2,332,924 | The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB. | The role of PKB in platelet function is poorly defined due to the lack of genuinely selective small-molecule inhibitors and limiting genetic models. Recently, a selective, non-ATP-competitive PKB inhibitor, Akti-1/2 has been reported, but the efficacy and specificity against PKB activation in platelet function is unkno... |
2,332,925 | Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis. | Farnesyltransferase inhibitors (FTIs) are novel anticancer drugs that inhibit the secretion of pro-angiogenic factors by Ras-transformed cancer cells. FTIs also inhibit angiogenesis in a rat corneal model, suggesting that FTIs have anti-angiogenic properties that extend beyond targeting cancer cells. Our hypothesis was... |
2,332,926 | [Effect of intrathecal administration of sufentanil at different doses on bupivacaine spinal anesthesia in gynecologic laparoscopy]. | To investigate the effect of sufentanil administered intrathecally at different doses on the clinical effect of bupivacaine spinal anesthesia in gynecologic laparoscopy.</AbstractText>Sixty patients with ectopic pregnancy undergoing elective laparoscopy (ASA class I-II) were randomized into 4 groups (groups A, B, C and... |
2,332,927 | Automated correction of room location errors in anesthesia information management systems. | Anesthesia information management systems (AIMS) and operating room information management systems (ORIMS) are both used in operating rooms (OR). Anesthesia providers use AIMS to document their care in near real-time, including milestone events, and these systems automatically record vital signs from patient monitors. ... |
2,332,928 | The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons. | GPIHBP1, a glycosylphosphatidylinositol-anchored endothelial cell protein of the lymphocyte antigen 6 (Ly6) family, plays a key role in the lipolysis of triglyceride-rich lipoproteins (e.g. chylomicrons). GPIHBP1 is expressed along the luminal surface of endothelial cells of heart, skeletal muscle, and adipose tissue, ... |
2,332,929 | [General anesthesia with remifentanil for a patient having sinoatrial block and constrictive pulmonary disorder]. | There is little report describing the effect of remifentanil on cardiac conduction system. We present a successful anesthetic management with remifentanil in a patient with sick sinus syndrome. A 66-year-old woman (31-kg, 121-cm) having sinoatrial (SA) block was diagnosed as having hepatic cell carcinoma, and radiofreq... |
2,332,930 | Transient trifascicular block complicating myocardial contusion after blunt chest trauma: a case report. | Cardiac contusion may be frequently found in patients with blunt chest trauma, and it presents clinically as a spectrum of injuries of varying severity, including transient disorders of impulse formation and propagation. A rare observation of transient trifascicular block in a previously fit 32-year-old man involved in... |
2,332,931 | The risks and benefits of therapy with aldosterone receptor antagonist therapy. | Spironolacotone and eplerenone are mineralocorticoid-blocking agents. These compounds block both the epithelial and non-epithelial actions of aldosterone with the latter assuming increasing clinical importance. Spironolactone and eplerenone both effectively reduce blood pressure either as mono- or add-on therapy; moreo... |
2,332,932 | An evaluation of the psychometric properties of the Smoking Self-Efficacy Questionnaire (SEQ-12) among Chinese cardiac patients who smoke. | Smoking cessation can reduce both morbidity and mortality among patients who have heart disease. China has the largest number of smokers in the world, and most smokers have low motivation to quit. Regular smoking cessation services are almost nonexistent in China, and little is known about the psychometric properties o... |
2,332,933 | Dietary tryptophan helps to preserve tryptophan homeostasis in pigs suffering from lung inflammation. | In pigs, inflammation modifies Trp metabolism and consequently could impact on Trp requirement for growth. In this study, the effects of lung inflammation, induced by the intravenous injection of complete Freund's adjuvant, and dietary Trp content on Trp metabolism and availability were investigated. Two dietary Trp co... |
2,332,934 | RXP-E: a connexin43-binding peptide that prevents action potential propagation block. | Gap junctions provide a low-resistance pathway for cardiac electric propagation. The role of GJ regulation in arrhythmia is unclear, partly because of limited availability of pharmacological tools. Recently, we showed that a peptide called "RXP-E" binds to the carboxyl terminal of connexin43 and prevents chemically ind... |
2,332,935 | [Arrhythmia triggered by stretching rabbit left ventricles and the block effect of streptomysin]. | To observe the effect of stretching left ventricles in the end of action potential on rabbit cardiac activity, and to investigate its possible mechanisms.</AbstractText>Stretch (120 mmHg, 50 ms) was applied in the end of action potential by the pressure-clamp technique to observe if there would be any changes in rabbit... |
2,332,936 | Thirty-year trends (1975-2005) in the magnitude and hospital death rates associated with complete heart block in patients with acute myocardial infarction: a population-based perspective. | The contemporary magnitude and prognostic implications of complete heart block (CHB) in patients with acute myocardial infarction (AMI) are unknown. As part of a community-based study of patients hospitalized with AMI in the Worcester, MA, metropolitan area, changes over time in the incidence rates of CHB complicating ... |
2,332,937 | The influence of permanent cardiac pacing on plasma levels of B-type natriuretic peptide in patients with sick sinus syndrome. | Unequivocal data presenting the impact of different pacing modes on B-type natriuretic peptide levels has never been published. The aim of the study was to assess changes of plasma B-type natriuretic peptide (BNP) during permanent cardiac pacing in patients with sick sinus syndrome (SSS).</AbstractText>Patients with SS... |
2,332,938 | ECGs in the ED.<Pagination><StartPage>499</StartPage><EndPage>500</EndPage><MedlinePgn>499-500</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/PEC.0b013e3181823a8c</ELocationID><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tanel</LastName><ForeName>Ronn E</ForeName><Initials>RE</Initi... | Disrrhythmia is frequent finding in high competitive athletes. Majority of heart rhythm abnormalities in athletes, suggested being benign, however, prognostic value of it is not yet well established. Purpose of the present study was to investigate heart rhythm and relationship of heart rhythm abnormalities with LV mass... |
2,332,939 | Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel. | We compared the clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in domain II (S5-S6) of human, hNa(v)1.5, cardiac Na(+) channels.</AbstractText>Full clinical evaluation of pedigree members through three generations of a Chinese family combined with SCN5A sequencing... |
2,332,940 | Cardiovascular magnetic resonance of the charcoal heart. | We report a case of malignant melanoma metastasis to the heart presenting as complete heart block. The highlight of the case is to demonstrate that silent cardiac metastasis is not uncommon and CMR has the potential to characterize these cardiac metastases and should be used routinely as a screening tool for those canc... |
2,332,941 | Feasibility of concurrent treatment with the scanning ultrasound reflector linear array system (SURLAS) and the helical tomotherapy system. | To evaluate the feasibility of concurrent treatment with the scanning ultrasound reflector linear array system (SURLAS) and helical tomotherapy (HT) intensity modulated radiation therapy (IMRT).</AbstractText>The SURLAS was placed on a RANDO phantom simulating a patient with superficial or deep recurrent breast cancer.... |
2,332,942 | Comparative study between bupivacaine heavy vs pethidine intrathecally to study early haemodynamic changes and postoperative analgesia in patients undergoing caesarean section. | To study early hemodynamic changes and duration of postoperative analgesia between two study groups of intrathecal pethidine and bupivacaine heavy in patients undergoing caesarean section.</AbstractText>Total number of 60 patients of ASA I and II, undergoing caesarean section were enrolled in the study. All the patient... |
2,332,943 | Acid-sensing ion and epithelial sodium channels do not contribute to the mechanoreceptor component of the exercise pressor reflex. | Amiloride, injected into the popliteal artery, has been reported to attenuate the reflex pressor response to static contraction of the triceps surae muscles. Both mechanical and metabolic stimuli arising in contracting skeletal muscle are believed to evoke this effect, which has been named the exercise pressor reflex. ... |
2,332,944 | Effect of ropivacaine skull block on perioperative outcomes in patients with supratentorial brain tumors and comparison with remifentanil: a pilot study. | Skull blockade for craniotomy may result in the reduction of sympathetic stimulation associated with the application of head pins ("pinning"), improvement in intraoperative hemodynamic stability, and a decrease in intraoperative anesthetic requirements. Postoperative benefits may include a decrease in pain, in analgesi... |
2,332,945 | [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. | The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). EAAs sustain seizure activity and induce neuropathology due to o... |
2,332,946 | Sedative and cardiorespiratory effects of acepromazine or atropine given before dexmedetomidine in dogs. | To test the hypothesis that acepromazine could potentiate the sedative actions and attenuate the pressor response induced by dexmedetomidine, the effects of acepromazine or atropine were compared in six healthy adult dogs treated with this alpha2-agonist. In a randomised block design, the dogs received intravenous dose... |
2,332,947 | [Night cardiac rhythm and conduction disturbances revealing obstructive sleep apnoea syndrome]. | There is a strong prevalence of sleep apnoea syndrome in general population. Cardiac arrhythmia and conduction disturbances during sleep may complicate this syndrome. We report the case of a 73-year-old patient to whom the sleep apnoea syndrome was diagnosed after varied heart blocks during the sleep. A treatment by co... |
2,332,948 | The efficacy of the psoas compartment block versus the intrathecal combination of morphine, fentanyl and bupivacaine for postoperative analgesia after primary hip arthroplasty: a randomized single-blinded study. | Intrathecal morphine and psoas compartment block represent two accepted techniques to provide postoperative analgesia after hip arthroplasty. We designed a prospective, randomized, single-blinded study to compare these two techniques.</AbstractText>Forty patients scheduled for primary hip arthroplasty under general ane... |
2,332,949 | The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels. | Ketanserin, a selective 5-HT receptor antagonist, prolongs the QT interval of ECG in patients. The purpose of the present study was to determine whether ketanserin would block human cardiac ether-à-go-go-related gene (hERG) potassium channels.</AbstractText>Whole-cell patch voltage-clamp technique was used to reco... |
2,332,950 | Repression of prespliceosome complex formation at two distinct steps by Fox-1/Fox-2 proteins. | Precise and robust regulation of alternative splicing provides cells with an essential means of gene expression control. However, the mechanisms that ensure the tight control of tissue-specific alternative splicing are not well understood. It has been demonstrated that robust regulation often results from the contribut... |
2,332,951 | Serpins show structural basis for oligomer toxicity and amyloid ubiquity. | Many disorders, including Alzheimer's, the prion encephalopathies and other neurodegenerative diseases, result from aberrant protein aggregation. Surprisingly, cellular toxicity is often due not to the highly-ordered aggregates but to the oligomers that precede their formation. Using serpins as a paradigm, we show how ... |
2,332,952 | Complex temporal patterns of spontaneous initiation and termination of reentry in a loop of cardiac tissue. | A two-component model is developed consisting of a discrete loop of cardiac cells that circulates action potentials as well as a pacing mechanism. Physiological properties of cells such as restitutions of refractoriness and of conduction velocity are given via experimentally measured functions. The dynamics of circulat... |
2,332,953 | [Loco-regional analgesia]. | The epidural analgesia is one of the most effective techniques for pain relief when it is indicated, but it can present potentially serious complications that must precociously be diagnosed and be treated. In the Critical Care setting, epidural analgesia is used for pain control after surgery or major trauma. The techn... |
2,332,954 | Comparison of potency of ephedrine and mephentermine for prevention of post-spinal hypotension in caesarean section. | The dosages and potency of intravenous mephentermine for prevention of post-spinal hypotension are not available in English literature. This study was designed to determine the minimum effective dose (ED50) of mephentermine and to compare its potency with that of ephedrine for prevention of post-spinal hypotension in p... |
2,332,955 | Endoscopic thoracic sympathectomy: at what level should you perform surgery? | Several interventions are possible on the sympathetic chain and the nomenclature has been confusing. The authors propose a uniform nomenclature for each procedure, mainly, sympathectomy for resection or ablation of the ganglion, sympathicotomy for the transaction of the chain, ramicotomy for the procedure preserving th... |
2,332,956 | In vivo PET imaging of cardiac presynaptic sympathoneuronal mechanisms in the rat. | The sympathetic nervous system of the heart plays a key role in the pathophysiology of various cardiac diseases. Small-animal models are valuable for obtaining further insight into mechanisms of cardiac disease and therapy. To determine the translational potential of cardiac neuronal imaging from rodents to humans, we ... |
2,332,957 | Efficacy and safety of morphine-6-glucuronide (M6G) for postoperative pain relief: a randomized, double-blind study. | The aim of the study was to assess analgesia and safety effects of a range of intravenous doses of M6G (10, 20 and 30 mg/70 kg), compared to placebo, in postoperative patients.</AbstractText>In a randomized, multicentre, double-blind study, patients undergoing knee replacement surgery under spinal anaesthesia were admi... |
2,332,958 | Quantitative overload: a source of stress in data-entry VDT work induced by time pressure and work difficulty. | It is hypothesized that quantitative overload impacts psycho-physiological attributes of data-entry operators, although previous research has focused primarily on different aspects of VDT work, such as working time and environment, work station, keyboards and so forth. The objective of this study was to examine the inf... |
2,332,959 | Emotional catharsis and aggression revisited: heart rate reduction following aggressive responding. | The authors tested two components of the catharsis theory of aggression: physiological tension reduction and aggressive drive reduction. On the basis of work in the stress-aggression literature, they also examined the moderating effect of impersonal stress exposure on cathartic reductions in heart rate following aggres... |
2,332,960 | Angiotensin II-dependent loss of cardiac function: mechanisms and pharmacological targets attenuating this effect. | Pharmacological inhibition of components of the renin-angiotensin-system is one of the major therapeutically options to treat patients with heart failure. This study hypothesized that angiotensin II (Ang II) directly depresses contractile function (cell shortening) by activation of transforming growth factor-beta(1) (T... |
2,332,961 | Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study. | Mechanical alternans in cardiac muscle is associated with intracellular Ca(2+) alternans. Mechanisms underlying intracellular Ca(2+) alternans are unclear. In previous experimental studies, we produced alternans of systolic Ca(2+) under voltage clamp, either by partially inhibiting the Ca(2+) release mechanism, or by a... |
2,332,962 | Rapid resensitization of purinergic receptor function in human platelets. | Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors (GPCRs), the P2Y(1) and P2Y(12) purinergic receptors. Recently, we demonstrated that both receptors desensitize and internalize in human platelets by differential kinase-dependent me... |
2,332,963 | B cell apotopes of the 60-kDa Ro/SSA and La/SSB autoantigens. | Apoptosis has been proposed to influence the initiation and diversification of autoimmunity to the Ro (SSA)/La (SSB) ribonucleoprotein (RNP) particle and serve as a target for autoantibody-mediated tissue injury. We have developed a new approach to B cell epitope mapping which identifies "apotopes," defined as epitopes... |
2,332,964 | Molecular analysis of early host cell infection by Trypanosoma cruzi. | Trypanosoma cruzi, the causative agent of Chagas heart disease, infects heart and other cells leading to cardiac arrest frequently followed by death. The disease affects millions of individuals in the Americas and is posing health problems because of blood transmission in the US due to large Latin American immigration.... |
2,332,965 | Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics. | Biological therapeutic agents (biologicals), such as monoclonal antibodies (mAbs), are increasingly important in the treatment of human disease, and many types of biologicals are in clinical development. During preclinical drug development, cardiovascular safety pharmacology studies are performed to assess cardiac safe... |
2,332,966 | The link between repolarisation alternans and ventricular arrhythmia: does the cellular phenomenon extend to the clinical problem? | T-wave alternans is considered a potentially useful clinical marker for the risk of ventricular arrhythmia in patients with heart disease. Cellular repolarisation alternans is thought to underlie T-wave alternans, and moreover, to cause re-entrant ventricular arrhythmia. This review examines the experimental and clinic... |
2,332,967 | Extremely low ventricular rate in a fetus with an isolated non-autoimmune complete congenital heart block. Case report. | Congenital complete heart block (CCHB) is an uncommon disorder with an incidence of about 1/20,000 in liveborn infants. It can occur in the setting of structurally normal heart or with structural disease; it is associated with high mortality and morbidity and requires a high index of suspicion for early diagnosis and t... |
2,332,968 | Prospective assessment of cardiovascular events in patients with partial and advanced interatrial conduction delay: a preliminary observation. | Major adverse cardiovascular events (MACE) have been investigated with partial interatrial block (IAB; P wave > or = 110 ms) but not with advanced IAB.</AbstractText>Twenty-four advanced IAB and 34 partial IAB patients were followed for 24 months for MACE, change in renal function and death.</AbstractText>Three pati... |
2,332,969 | Efficacy of monensin and tylosin in finishing diets based on steam-flaked corn with and without corn wet distillers grains with solubles. | Three hundred seventy-one crossbred-yearling heifers (299 +/- 9 kg initial BW) were obtained from a common source and used in a randomized complete-block designed finishing study. A 2 x 3 factorial arrangement of treatments was used with one factor being diet: based on steam-flaked corn finishing diet (SFC) or SFC plus... |
2,332,970 | Comparison of midazolam sedation with or without fentanyl in cataract surgery. | We compared the effect of midazolam sedation with or without fentanyl on the hemodynamic parameters, sedation, and pain and satisfaction profile in cataract surgery. Two hundred and ten patients were randomly allocated to receive either midazolam 1 mg i.v. (Group M, n = 101) alone or with fentanyl 25 microg (Group MF, ... |
2,332,971 | Post-mastectomy radiotherapy in Denmark: from 2D to 3D treatment planning guidelines of The Danish Breast Cancer Cooperative Group. | This paper describes the procedure of changing from 2D to 3D treatment planning guidelines for post-mastectomy radiotherapy in Denmark. The aim of introducing 3D planning for post-mastectomy radiotherapy was to optimize the target coverage and minimize the dose to the normal tissues. Initially, it was investigated whet... |
2,332,972 | Inhibition of MCP-1/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model. | Transplant arteriopathy is the leading cause of long term morbidity and mortality following heart transplantation. Animal models have demonstrated that monocyte chemoattractant protein (MCP)-1 is induced early after transplant in cardiac and aortic allografts. We have previously reported that deficiency of MCP-1 or its... |
2,332,973 | Frontrunners in novel pharmacotherapy of COPD. | The mainstay of current drug therapy is long-acting bronchodilators; several longer acting inhaled beta(2)-agonists and muscarinic antagonists (and combinations) are now in development. No treatments reduce the progression or suppress the inflammation of COPD. With better understanding of the inflammatory and destructi... |
2,332,974 | Expression profile and characterisation of a truncated KCNQ5 splice variant. | Ion channels encoded by KCNQ genes (1-5) are key regulators of membrane properties in many cell types. The KCNQ5 gene was the last to be identified and has three splice variants that are expressed in human brain and skeletal muscle. The KCNQ5 encoded channel possesses M-current properties and so far no channelopathy ha... |
2,332,975 | Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model. | Dysfunction or pharmacologic inhibition of repolarizing cardiac ionic currents can lead to fatal arrhythmias. The hERG potassium channel underlies the repolarizing current I(Kr), and mutations therein can produce both long and short QT syndromes (LQT2 and SQT1). We previously reported on the diphenylurea compound NS164... |
2,332,976 | Peripheral heart blocks associated with myocardial infarcts: clinical diagnosis based on experimental findings. | Septal necrosis + peripheral left blocks. Because of an extensive septal necrosis, the manifestation of the initial ventricular activation forces decreases in the precordial leads. With left bifascicular block (LASB + LPSB), the first ventricular activation forces become more evident and the electrical signs of septal ... |
2,332,977 | Enhanced calreticulin expression promotes calcium-dependent apoptosis in postnatal cardiomyocytes. | Calreticulin (CRT) is one of the major Ca2+ binding chaperone proteins of the endoplasmic reticulum (ER) and an unusual luminal ER protein. Postnatally elevated expression of CRT leads to impaired development of the cardiac conductive system and may be responsible for the pathology of complete heart block. In this stud... |
2,332,978 | Validation of the MEDFICTS dietary assessment questionnaire in a diverse population. | The National Cholesterol Education Program (NCEP) recommends MEDFICTS, a rapid screening instrument for dietary fat, to assess adherence to the Adult Treatment Panel (ATP) III Therapeutic Lifestyle Changes (TLC) diet (score <40 points indicates intake of <7% of energy from saturated fat, <30% of energy from to... |
2,332,979 | The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling. | Endogenous platelet activating factor (PAF) is involved in heart ischemic preconditioning. PAF can also afford pharmacological preconditioning. We studied whether mitochondrial-ATP-sensitive K(+) (mK(ATP)) channels and reactive oxygen species (ROS) are involved in PAF-induced cardioprotection. In Group 1 control hearts... |
2,332,980 | Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans. | Passive muscle stretch performed during a period of post-exercise muscle ischemia (PEMI) increases muscle sympathetic nerve activity (MSNA), and this suggests that the muscle metabolites may sensitize mechanoreceptors in healthy humans. However, the responsible substance(s) has not been studied thoroughly in humans. Hu... |
2,332,981 | Regulation of apoptosis by the redox state of cytochrome c. | Cytochrome c, released from mitochondria into the cytosol, triggers formation of the apoptosome resulting in activation of caspases. This paper reviews the evidence for and against the redox state of cytochrome c regulating apoptosis, and possible mechanisms of this. Three research groups have found that the oxidized f... |
2,332,982 | Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. | Hsc70 with its cochaperone, either auxilin or GAK, not only uncoats clathrin-coated vesicles but also acts as a chaperone during clathrin-mediated endocytosis. However, because synaptojanin is also involved in uncoating, it is not clear whether GAK is an essential gene. To answer this question, GAK conditional knockout... |
2,332,983 | Sevoflurane concentrations required to block autonomic hyperreflexia during transurethral litholapaxy in patients with complete spinal cord injury. | Autonomic hyperreflexia (AHR) is a potentially life-threatening hypertensive condition that occurs in patients with high spinal cord injury (SCI). The current study was aimed to determine sevoflurane concentrations that block AHR in SCI patients.</AbstractText>The study involved 28 patients with chronic, complete SCI s... |
2,332,984 | Relapsing polychondritis presenting with complete heart block. | Relapsing polychondritis (RP) is a rare autoimmune disease characterized by recurrent inflammation of cartilagenous structures, including the ears, nose, trachea, and joints. Cardiovascular involvement is relatively common, but involvement of the conduction system leading to various degrees of heart block is a rare and... |
2,332,985 | [Neuroprotection in perinatal hypoxic-ischemic encephalopathy. Effective treatment and future perspectives]. | The aim of this paper is to review the results of recent clinical studies of some therapies that have demonstrated a neuroprotective effect in perinatal hypoxic-ischemic encephalopathy (HIE) and to present the future perspectives of other clinical and basic research investigations. THERAPIES WITH DEMONSTRATED CLINICAL ... |
2,332,986 | Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. | We describe a case of successful resuscitation with an i.v. lipid infusion of local anesthetic-induced cardiovascular toxicity after supraclavicular brachial plexus block with mepivacaine and bupivacaine. Lipid therapy was initiated after 10 min of unsuccessful resuscitation and resulted in restoration of cardiovascula... |
2,332,987 | Acute inhibition of superoxide formation and Rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane A2 analogue, U46619. | The over-production of superoxide (O(2)(-)) derived from NADPH oxidase (NOX) plays a central role in cardiovascular diseases. By contrast, nitric oxide (NO) and prostacyclin (PGI(2)) are vasculoprotective. The effect of the NO donor, NONOate and iloprost on O(2)(-) formation, p47(phox) and Rac(1) activation in human va... |
2,332,988 | [Real time intracardiac electrograms for the diagnosis of pacemaker malfunction]. | Chronic ventricular lead dislodgement is an infrequent complication of pacemaker implantation. Occasionally, the dislodged lead may sense and capture a chamber in which the lead was not originally positioned. Intracardiac real time electrograms and channel markers are useful tools for the diagnosis of pacemaker malfunc... |
2,332,989 | [Peculiarities of Ca2+ regulation of functional activity of myocardium of frog Rana temporaria]. | To elucidate role of intra- and extracellular Ca2+ in regulation of rhythm and strength of frog heart contractions, there were studied ECC and isometric contraction of myocardium preparations in response to verapamil, adrenaline, and blockers of alpha- and beta-adrenoreceptors. It has been shown that after an intramusc... |
2,332,990 | Enflurane requirement for blocking adrenergic responses to incision in infants and children. | Enflurane is one of the most commonly used inhaled anesthetics in China, but its requirement to block adrenergic responses after skin incision in pediatric patients is still unknown. This study was to determine the minimum alveolar anesthetic concentration (MAC) of potent inhaled anesthetics required to blunt the adren... |
2,332,991 | Clinical comparison of cardiorespiratory effects during unilateral and conventional spinal anaesthesia. | Spinal anaesthesia is widely employed in clinical practice but has the main drawback of post-spinal block hypotension. Efforts must therefore continue to be made to obviate this setback</AbstractText>To evaluate the cardiovascular and respiratory changes during unilateral and conventional spinal anaesthesia.</AbstractT... |
2,332,992 | Life-threatening pacemaker dysfunction associated with therapeutic radiation: a case report. | Reports about pacemaker (PM) dysfunction during irradiation (IR) are very rare, which is because of the extensive protective mechanisms that exist in these devices against electromagnetic interference (EMI). We report a case in which one of the most clinically relevant type of PM malfunctions, a runaway PM, occurred du... |
2,332,993 | Signs of myocardial ischaemia after injection of oxytocin: a randomized double-blind comparison of oxytocin and methylergometrine during Caesarean section. | ECG changes, similar to those seen during myocardial ischaemia, together with symptoms of chest pain, are common during Caesarean section (CS). We hypothesized that oxytocin administration has cardiovascular effects leading to these symptoms and ECG changes.</AbstractText>Forty women undergoing elective CS under spinal... |
2,332,994 | Remifentanil versus fentanyl in combination with midazolam for retrobulbar block in cataract surgery. | To compare the effects of fentanyl or remifentanil in combination with midazolam on hemodynamic parameters, pain, and satisfaction profile in cataract surgery.</AbstractText>This randomized, double blind, prospective study was conducted between 10 and 20th July 2005 at Kudret Eye Hospital, Ankara, Turkey. Patients sche... |
2,332,995 | Is sitaxsentan a good therapeutic option for pulmonary arterial hypertension associated with connective tissue disease? | Agents that indiscriminately block endothelin receptors have been shown to cause moderate improvements in the outcomes of patients who have pulmonary arterial hypertension (PAH) as a complication of connective tissue disease (CTD). Girgis et al. investigated the effects of sitaxsentan, a selective endothelin receptor t... |
2,332,996 | Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply. | During low-to-high work transition in adult mammalian heart in vivo the concentrations of free ADP, ATP, PCr (phosphocreatine), P(i) and NADH are essentially constant, in striking contrast with skeletal muscle. The direct activation by calcium ions of ATP usage and feedback activation of ATP production by ADP (and P(i)... |
2,332,997 | Bending of z-lines by mechanical stimuli: an input signal for integrin dependent modulation of ion channels? | We studied which components of mechanical cell deformation are involved in "stretch modulated ion currents" (SMIC). Murine ventricular myocytes were attached to glass coverslips and deformed in x, y and z with a 16 microm thin glass stylus (S) of calibrated stiffness. Three-dimensional confocal microscopy characterized... |
2,332,998 | Lipid emulsion as rescue for local anesthetic-related cardiotoxicity. | Regional anesthesia techniques use local anesthetics to provide sensory and motor block for surgical intervention. Intravascular absorption of the local anesthetics may induce toxic effects, such as seizure activity or cardiac depression, leading to cardiac arrest. Standard, prolonged resuscitation efforts are not alwa... |
2,332,999 | Factors that affect pulse wave time transmission in the monitoring of cardiovascular system. | Vascular transit time (VTT) can be defined as the first heart sound of the phonocardiography (PCG) signal to its arrival at the photoplethysmography (PPG). Studies have shown that monitoring VTT can be useful as an early prognosis of cardiac diseases. However, there is limited study conducted to understand the physiolo... |
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