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27,900 | [Diagnosis and treatment of pulmonary heart before and after hospitalization]. | Prevalence of pulmonary heart among patients with cardiovascular pathology is
5%. Clinical picture of pulmonary heart comprises symptoms of underlying disease
and signs of pulmonary and cardiac failure. The following instrumental methods
of investigation are very helpful for diagnosis of pulmonary heart: chest
roen... |
27,901 | [Epidemiological aspects of metabolic syndrome.]. | During 15 years criteria of metabolic syndrome has undergone definite changes.
According to Adult Treatment Panel III of National Cholesterol Education Program
metabolic syndrome is diagnosed in the presence of 3 of 5 following signs: waist
circumference>/=102 or small i, Ukrainian88 cm in men and women, respectivel... |
27,902 | [Effect of moxonidine on parameters of lipid metabolism in patients with
metabolic syndrome.]. | AIM: To compare effects of moxonidine and lisinopril on parameters of lipid
metabolism in patients with metabolic syndrome.
METHODS: Moxonidine (0.2-04 mg/day) and lisinopril (10-20 mg/day) were given to
25 and 24 patients, respectively. Blood pressure, heart rate, parameters of
lipid profile and fasting blood gluco... |
27,903 | [First experience with the use of bone marrow stem cells for regeneration
therapy of ischemic heart disease.]. | AIM: To elucidate feasibility of the use of autologous bone marrow stem cells in
candidates to myocardial revascularization- patients with ischemic heart disease
and cardiosclerosis after myocardial infarction.
METHODS: Between January 2003 and January 2004 25 men aged 56.3+/-5.4 years with
ischemic heart disease we... |
27,904 | [Assessment of antianginal and antiischemic effect of trimetazidine and its
effects on myocardial perfusion in patients with ischemic heart disease and
stable angina.]. | AIM: To assess antianginal and antiischemic effects of trimetazidine and its
action on myocardial perfusion in patients with ischemic heart disease and
stable angina.
MATERIAL: Open trimetazidine was given for 3 months to 53 nitroglycerine and
beta-blocker treated men aged 47-69 (mean age 60.2+/-0.85) years with isc... |
27,905 | [The study of cerebral oxygenation and central hemodynamics in patients with
ischemic heart disease at rest and during physical effort.]. | Cerebral oxygenation (rSO(2)) in the region of sagittal sinus and main
hemodynamic parameters were measured in 112 patients with ischemic heart disease
and class II-III angina. Four groups of patients were distinguished according to
degree of rSO(2) lowering. Hemodynamics and oxygen transport function of the
blood ... |
27,906 | [Comparison of various methods of assessment of heart rate variability including
simple cardiovascular reflex tests as predictors of sudden cardiac death after
myocardial infarction.]. | Long term heart rate variability is used for prediction of sudden cardiac death
(SD). There are simpler methods of assessment of autonomic cardiac control -
registration of heart rate response to reflex tests and determination of heart
rate variability (HRV) on short ECG recordins. Comparative value for prognosis
o... |
27,907 | [The Use of Clopidogrel in Conjunction With Thrombolytic Therapy in PatientsWith
ST-Elevation Acute Myocardial Infarction.]. | Clopidogrel (300 mg before initiation of thrombolysis and 75 mg/day thereafter)
was given to 46 of 131 patients with streptokinase treated ST-elevation acute
myocardial infarction. Mortality and efficacy of thrombolysis were similar in 2
groups, however deaths of acute heart failure were distributed unevenly (0 in
... |
27,908 | [Effect of carvedilol on blood levels of cytokines and symptoms of heart failure
in patients with postinfarction cardiac dysfunction.]. | Effect of 6 months treatment with carvedilol (25 mg/day) on blood levels of
cytokines (interleukins 1alpha, 2, 6, 8, tumor necrosis factor alpha) and
clinical symptoms of heart failure was studied in patients with cardiac
dysfunction after myocardial infarction. Patients with NYHA class II heart
failure, ejection f... |
27,909 | [Low density lipoprotein receptor gene mutations in patients with clinical
diagnosis of familial hypercholesterolemia.]. | Low density lipoprotein receptor (LDLR) gene mutations cause familial
hypercholesterolemia which is associated with elevated risk of ischemic heart
disease.
AIM: To define LDLR gene mutations in unrelated patients with heterozygous
familial hypercholesterolemia in Russia.
METHODS: PCR- single-strand conformation pol... |
27,910 | [Stroke and Other Thromboembolic Complications of Atrial Fibrillation. Part III.
Prevention With Other Antithrombotic Agents.]. | In part IV of a series of papers on epidemiology and drug prevention of stroke
and other thromboembolic complications of atrial fibrillation the authors
present data on clinical pharmacology of low molecular weight heparins,
ximelagatran, indobufen, triflusal, dipyridamole, ticlopidine, and clopidogrel.
Efficacy of... |
27,911 | [Simple cardiovascular reflex tests in prediction of sudden death after
myocardial infarction: which method to prefer?]. | BACKGROUND: Some evidence exists that heart rate response to simple provocative
maneuvers may predict sudden cardiac death (SD) after myocardial infarction
(MI). However optimal test has not been not established yet. Aim of this study
was to compare prognostic value of different noninvasive reflex tests after MI.
ME... |
27,912 | [Correction of baroreflex sensitivity impairment and efficacy of prevention of
sudden arrhythmic death in patients with postinfarction left ventricular
dysfunction]. | Baroreflex sensitivity was assessed in 287 patients with history of myocardial
infarction and left ventricular ejection fraction < or =40% by phenylephrine
test and was found to be depressed (4.44+/-0.38 ms/mm Hg). Repeat study in 3, 6
and 12 months revealed substantial improvement of baroreflex sensitivity in
pati... |
27,913 | [Prognostication of the course of stable ischemic heart disease by exercise
stress echocardiography]. | We analyzed data from 549 patients (450 with high and 99 -- low pretest
probability of ischemic events). Duration of observation was 12-42 (mean
20.1+/-11.6) months. End points were death, nonfatal myocardial infarction, and
revascularization. Cox proportional hazards model was used for assessment of
relationship b... |
27,914 | [Amiodarone-associated thyroid dysfunction: prevalence and possibilities of
correction]. | During 1 year of amiodarone intake development of amiodarone-associated thyroid
dysfunction was observed in 25% of patients (hypothyroidism and thyrotoxicosis
in 19.2 and 5.8%, respectively). Development of hypothyroidism was not
accompanied with loss of antiarrhythmic efficacy of amiodarone and therapy with
L-thyr... |
27,915 | [Assessment of efficacy of combined therapy with antihypertensive agents and
biguanides in patients with metabolic syndrome]. | To compare effects of antihypertensive and combined therapy on 24-hour blood
pressure, biochemical parameters and chronic hyperinsulinemia in patients with
metabolic syndrome. 54 patients with metabolic syndrome were observed during 8
weeks. 28 patients (group A) were treated with antihypertensive agents (calcium
a... |
27,916 | [Clinical value of degree of blood pressure lowering during use of effective
doses of antianginal drugs]. | Paired exercise tests with single doses of verapamil, nifedipine, propranolol,
buccal nitroglycerin (trinitrolong), sustained release oral nitroglycerin, and
placebo were performed in 101 patients with stable class II-III angina and the
drug causing longest exercise duration was selected for long term therapy.
Effi... |
27,917 | [Clinical efficacy of citalopram in patients with hypertension and concomitant
depression]. | Patients (n=28) with mild to moderate hypertension and depression were given
enalapril (20 mg/day). If target blood pressure was not achieved in 10 days
hydrochlorothiazide (12.5 mg/day) was added. These patients were randomized into
2 groups in one of which antihypertensive therapy was supplemented with
citalopram... |
27,918 | [Increased platelet aggregation induced activity by anti-glycoprotein IIb/IIIa
antibody in patients with acute coronary syndrome]. | Interaction of glycoprotein (GP) IIb/IIIa with fibrinogen is the final and key
reaction in platelet aggregation. In order to evaluate GP IIb-IIIa functional
activity in patients with acute coronary syndrome (ACS) we measured platelet
aggregation induced by monoclonal antibody CRC54 which is directed against GP
IIb/... |
27,919 | [Selective microproteinuria as a marker of incipient renal impairment in
patients with hypertension]. | Incidence of chronic renal failure has a worldwide tendency to growth.
Hypertension occupies an important place among causes of this upward trend. That
is why in patients with hypertension and incipient changes of the kidneys it
seems most appropriate to use antihypertensive drugs with renoprotective
properties. Ea... |
27,920 | [Statins: therapeutic cascade of their effects]. | Concept of sequence and time of appearance of various effects of statins is
presented. Apart from hypolipidemic action due to inhibition of HMG CoA
reductase activity statins exert multiple pleiotropic effects. Combination of
these effects makes statins a unique instrument for solution of global tasks of
prevention... |
27,921 | [Development of transmural myocardial infarction in young persons with intact
coronary arteries during methadone use for the treatment of heroine addiction]. | Linkage between acute coronary syndrome and narcotic drug (cocaine) intake was
first described by D. Colleman in 1982. However risk of development of acute
myocardial infarction during replacement therapy after opioid withdrawal has not
been elucidated. The paper contains description of two cases of development of
... |
27,922 | [Arterial hypertension and cerebrovascular pathology. Current status of the
problem]. | In the process of development and progression of arterial hypertension
hypertensive cerebral angiopathy is formed - that is a complex of intricate
primarily destructive (acute and recurring) and secondary reparative changes and
adaptive processes occurring on all structural and functional levels of cerebral
vascula... |
27,923 | [Prognostication of coronary atherosclerosis for selection of tactics of
management of patients with ischemic heart disease]. | AIM: To create an artificial neural network for prognostication of coronary
atherosclerosis and thus selection of patients requiring invasive interventions.
METHODS AND RESULTS: Efficacy of prognostication made by a physician and by a
model was compared basing on probabilistic estimates with consideration of
individ... |
27,924 | [Clinical efficacy of tianeptine in patients with ischemic heart disease and
comorbid depression]. | Ischemic heart disease patients (20 men, 20 women, age 36-72 years) with class
II-III effort angina and depression (Beck Depression Inventory -- BDI -- score >
or = 19) were randomized to standard therapy were treatment of stable ischemic
heart disease (control group) or standard therapy plus tianeptine 37.5 mg/day.... |
27,925 | [Single-photon emission computed tomography in diagnosis of left ventricular
post-infarction aneurysm]. | AIM: To assess value of single-photon emission computed tomography with
(99m)Tc-sestamibi ((99m)Tc MIBI SPECT) for detection of post-infarction left
ventricular aneurysm in patients with coronary artery disease.
MATERIAL: Fifty nine patients were operated upon because of coronary heart
disease. In 27 patients with p... |
27,926 | [Simple cardiovascular reflex test during hospitalization due to myocardial
infarction predicts sudden but not non-sudden cardiac death during 2 years
follow up]. | Prognostic significance of heart rate (HR) response to easy to perform
provocative maneuvers such as Valsalva maneuver and deep breath requires further
elucidation.
METHODS: Valsalva maneuver with calculation of Valsalva ratio (VR) and deep
breath test with calculation of difference between average maximal and minim... |
27,927 | [Efficacy and tolerability of felodipine based antihypertensive therapy in
hospitalized patients with hypertension]. | AIM: To compare efficacy and tolerability of felodipine based antihypertensive
therapy with those of standard hospital treatment of hypertension.
MATERIAL: Inhospital patients were randomized 1:2 to standard antihypertensive
therapy or to therapy which included felodipine (n=50 and 100, 36 and 35% men,
mean age 66.0... |
27,928 | [Levels of sex hormones in obese women with hypertension during various periods
of reproductive activity]. | AIM: To assess effects of hypertension and obesity on blood plasma levels of sex
hormones and gonadotropins in fertile and postmenopausal women.
MATERIAL: We assessed endocrinological status and measured levels of sex
hormones and gonadotropins in 228 women with grade I-III hypertension (WHO,
1999) and 114 normotens... |
27,929 | [Decreased ATP-synthesis ability of brain mitochondria in spontaneously
hypertensive rats]. | It has been shown previously that a decrease of ATP amount and changed balance
of other macroergic phosphates occurs in different tissues of spontaneously
hypertensive rats (SHR) compared with control normotensive rats (WKY).
AIM: To assess the ability of SHR brain isolated mitochondria to synthesize ATP
and to eluc... |
27,930 | [Stroke and other tromboembolic complications in atrial fibrillation. Part I.
Prevalence and risk factors]. | In a series of papers the authors discuss problems of epidemiology and drug
prevention of stroke and other thromboembolic complications in patients with
atrial fibrillation. Part I contains data on frequency of strokes in different
categories of patients as well as review of main risk factors and mechanisms of
deve... |
27,931 | [The role of insulin resistance in diagnosis of metabolic syndrome]. | Early diagnosis of metabolic syndrome is based on detection of insulin
resistance, hyperinsulinemia, and clinical presentations of this syndrome.
Differences in approaches to diagnosis of metabolic syndrome and its multi
component nature hamper comparison of results of different studies and
elaboration of generaliz... |
27,932 | [Matrix metalloproteinases, C-reactive protein, and markers of thrombinemia in
patients with stable angina and restenoses after percutaneous coronary
interventions.]. | AIM: To elucidate relationships between blood levels of matric
metalloproteinases (MMP), C-reactive protein (CRP), markers of thrombinemia, and
development of restenosis after percutaneous coronary interventions (PCI) in
patients with stable angina.
MATERIAL: Patients (n=78, mean age 55.7+/-0.9 years) after successf... |
27,933 | [The role of stress-echocardiography in diagnostics of hemodynamically
significant coronary artery stenosis and determination of indications for
myocardial revascularisation.]. | In 118 patients dobutamine (n=108) or exercise (n=10) stress-echocardiography
and coronary angiography were carried out within time interval of 4 weeks.
Retrospective analysis of data obtained showed that sensitivity and specificity
of stress echocardiography for detection of more than 70% coronary artery
stenosis ... |
27,934 | [Cooperative study "posthospital rehabilitation of patients with coronary heart
disease after acute coronary incidents" conducted in moscow region.]. | Effect of physical training, therapy with extended-release nicotinic acid
(enduracin) or their combination on clinical course of the disease, physical
working capacity, hemodynamics and blood lipids was studied in 136 patients.
Patients were recruited 8-12 weeks after onset of acute coronary incident in
several hos... |
27,935 | [Effect of high concentrations of glucose on physiological parameters of
platelets in patients with ischemic heart disease.]. | Analysis of functional state of the erythrocyte system was carried out in 45
patients with stable class II and III angina including those with concomitant
non insulin dependent diabetes and in 15 practically healthy subjects. The
analysis was made in the process of upsetting the balance of the erythrocyte
system by... |
27,936 | [Favorable effect of trimetazidine on clinical state and left ventricular
function postinfarction period.]. | AIM: To assess effect of trimetazidine on clinical course of postinfarction
period and restoration of left ventricular myocardium.
MATERIAL AND METHODS: 1.5-2.0 months after acute myocardial infarctions 123
patients receiving conventional therapy (aspirin, beta-blockers, angiotensin
converting enzyme inhibitors, nit... |
27,937 | [Tumor necrosis factor alpha and interferon alpha in patients with
myocarditis.]. | AIM: To elucidate the role of tumor necrosis factor alpha (TNF alpha) and
interferon alpha (INF alpha) in pathogenesis of infectious-immune myocarditis
(M) and myocarditic cardiosclerosis (MCS).
MATERIAL AND METHODS: Patients with infectious-immune myocarditis (n=27) and
myocarditic cardiosclerosis with symptoms of ... |
27,938 | [Spectral analysis of heart rate variability in diagnosis of vegetative
autonomic dysfunction in patients with attacks of atrial fibrillation.]. | AIM: Elucidation of possible role of suprasegmental and segmental autonomic
vegetative disturbances in pathogenesis of paroxysmal atrial fibrillation.
MATERIAL: Untreated patients (n=22) with nonrheumatic paroxysmal atrial
fibrillation and 10 healthy subjects.
METHODS: Clinical cardiological and neurological examinat... |
27,939 | [Antiarrhythmic Efficacy of a New Class III Antiarrhythmic Drug RG-2.]. | We studied effects of a new class III antiarrhythmic drug RG-2 in a canine model
of vagally-mediated atrial fibrillation (AF). RG-2 was intravenously infused to
anesthetized open-chest dogs in progressive doses (5, 10, 20 and 40 mg/kg, n=6)
during vagally-induced AF. RG-2 significantly dose-dependently increased atr... |
27,940 | [Achievements of invasive cardiology 2003. Part I.]. | The authors present a review of research works completed or conducted in 2003
which according to their opinion contributed most to the rapidly progressing
field of invasive/interventional cardiology. The year passed was characterized
by wide introduction into clinical practice of stents coated with antirestenotic
a... |
27,941 | [Genetic Predictors of Unfavorable Course in High Risk Patients With Ischemic
Heart Disease. Data of Follow-up for Two Years.]. | Prognostic value of clinical parameters and polymorphisms of apo-B, apo-E, LPL,
, PPARA, PPARG2 genes was studied in 154 patients with acute unstable angina.
Duration of follow-up was 2 years. Diabetes (OR 3.29, 1.28-8.50, p=0.014),
history of stroke (OR 6.11, 1.21-31.00, p=0.029), changes of terminal part of
ventr... |
27,942 | [The place of multispiral computed tomography in diagnostics of ischemic heart
disease.]. | Multispiral computed tomography (CT) of the heart with detection of coronary
artery calcification as well as clinical examination, stress tests, single
photon emission computer tomography at rest and during stress, and/or stress
echocardiography were used in the study of 56 patients with and 26 without
ischemic hea... |
27,943 | [Dynamics of QT-Dispersion During Bicycle Exercise Test in Assessment of
Functional State and Prognosis in Patients With Ischemic Heart Disease.]. | Changes of QT-interval dispersion during bicycle exercise test were registered
in 68 patients with ischemic heart disease and stable angina. According to
results of 5 year follow-up 3 groups of patients were distinguished - with
cardiac events (n=20), with stable clinical course (n=30), and with clinical
remission ... |
27,944 | [Expression of contractile and cytoskeletal proteins in myocardium of patients
with dilated cardiomyopathy.]. | Dilated cardiomyopathy (DCM) is characterized by enlargement and dilation of all
heart compartments associated with serious decrease of its contractile function.
DCM hallmark is the combination of dystrophic and hypertrophic alterations of
cardiomyocytes. Since the power output of cardiac cells is directly related t... |
27,945 | [Search for an optimal therapy of patients with atrial fibrillation (results of
many years of comparison of three treatment strategies).]. | Patients with nonrheumatic atrial fibrillation (n=465, mean age 59.4+/-3.8
years) received controlled therapy for 7.4+/-1.6 years. Group 1 comprised 306
patients with paroxysmal and persistent atrial fibrillation who after
restoration of sinus rhythm received antiarrhythmic therapy aimed at prevention
of recurrence... |
27,946 | [The role of atrial pressure in spontaneous initiation of atrial fibrillation in
the dog.]. | Atrial fibrillation (AF) frequently occurred under conditions associated with
atrial dilatation (stretch) or vagal hyperactivity. To study possible role of
atrial stretch in spontaneous initiation of vagal AF we compared changes of
right atrial pressure (RAP) and activation patterns during AF beginning. In
anesthet... |
27,947 | [Achievements of Invasive Cardiology 2003. Part II.]. | The authors present a review of research works completed or conducted in 2003
which according to their opinion contributed most to the rapidly progressing
field of invasive/interventional cardiology. The year passed was characterized
by wide introduction into clinical practice of stents coated with antirestenotic
a... |
27,948 | [Stroke and other thromboembolic complications of atrial fibrillation. Part v.
The use of drugs without antithrombotic or antiarrhythmic properties.]. | In part V of a series of papers on epidemiology and drug prevention of stroke
and other thromboembolic complications of atrial fibrillation the authors
analyze data of randomized trials exhibiting ability of long term use of
beta-adrenoblockers, angiotensin converting enzyme inhibitors, angiotensin
receptor antagon... |
27,949 | [Myocardial bridge - congenital anomaly of coronary vasculature.]. | Coronary artery lumen compression during systole by a myocardial bridge can
cause myocardial ischemia and even necrosis. Myocardial bridges represent a
variant of norm or congenital anomaly of coronary vasculature. They belong to
relatively frequent autopsy findings (5.4-85.7%) and are most often located over
left ... |
27,950 | [Effectiveness of external mechanical recanalization in the treatment of
cardiogenic shock in patients with myocardial infarction]. | Attempts of mechanical coronary artery recanalization (angioplasty) were
undertaken in 52 patients with acute myocardial infarction and cardiogenic
shock. In 28 patients (53.9%) recanalization was successful while in 24 it was
not (in-hospital mortality 39.3 and 87.5%, respectively, p<0.001). Overall 11
and 21 pati... |
27,951 | [Hypolipoproteinemia and secondary role of atherosclerosis in the development of
ischemic heart disease in patients with polycythemia vera]. | Relationship between presence of coronary heart disease (CHD), coronary risk
factors (parameters of lipid transport system and hypertension) and disturbances
of microcirculation was studied in patients with myeloproliferative blood
disease Polycythemia Vera (PV). Probability of tissue (including blood vessel
wall) ... |
27,952 | [Thyroid dysfunction in long-term amiodarone administration. Correlation of the
antiarrhythmic activity of amiodarone with its effect on thyroid function]. | Relationship between amiodarone-associated thyroid dysfunction and
antiarrhythmic activity of amiodarone was studied in 27 patients (13 with
hypothyroidism, 8 with hyperthyroidism, 6 with euthyroid hyperthyroxinemia).
Amiodarone-associated hypothyroidism and euthyroid hyperthyroxinemia were not
associated with loss... |
27,953 | [Heart rate variability in patients with paroxysmal atrial fibrillation of
various etiologies]. | Heart rate variability (HRV) was assessed on 24 hour Holter ECG recordings from
32 healthy persons and 54 patients with paroxysmal atrial fibrillation (AF) of
different etiology (hypertension, ischemic heart disease, rheumatic mitral valve
disease, idiopathic AF) aged 45-73 years. Nocturnal, diurnal and 24 hour HRV ... |
27,954 | [Effect of clonazepam and antiarrhythmic drugs on heart rate variability in
patients with paroxysmal atrial fibrillation]. | AIM: To study direction and intensity of autonomic changes in patients with
paroxysmal atrial fibrillation (PAF) treated with clonazepam and their dynamics
during antiarrhythmic therapy.
MATERIAL: Patients with nonrheumatic PAF during effective clonazepam monotherapy
or ineffective antiarrhythmic therapy (n=95), unt... |
27,955 | [Angiotensin converting enzyme, NO-synthase, and endothelin-1 genes and left
ventricular hypertrophy in natives of Yakutia with hypertensive disease]. | Association of polymorphic markers G7831A of ACE gene, Lys198Asn of endothelin-1
(EDN1) gene, and 4a/4b of NOS3 gene with characteristics of structure and
function of the left ventricle was studied in 70 (31 men and 39 women) natives
of Yakutia with hypertension. Mean age of patients was 48.3+/-0.74 years,
duration... |
27,956 | [Structural changes of the myocardium and 24-hour blood pressure profile in
subjects with hypertension studied during expedition work in the Far North]. | Echocardiography and 24-hour BP monitoring were carried out in 177 men with
stage 1 and 2 essential hypertension aged 25-59 years when they worked the Far
North shift (group l) and in 75 patients with essential hypertension living in
moderate climatic zone (group 2). Normal left ventricular geometry was found in
10... |
27,957 | [An experience of the use of stenting for recurrence of myocardial ischemia
after coronary artery bypass grafting]. | Coronary artery stenting was carried out in 18 patients with angina recurrence
29.3+/-7.6 after coronary artery bypass grafting. Paired bicycle exercise tests,
(199)Tl single photon emission tomography and graft angiography were used in
evaluation of patients. Occlusions of 1 or 2 venous grafts were found in 38.9%, ... |
27,958 | [Measurement of arterial stiffness and its clinical value]. | Noninvasive method of assessment of arterial stiffness by means of measurement
of velocity of pulse wave propagation in presented in the review. Mechanical
properties of arterial wall and pathogenesis of arterial remodeling are
described. Correlation of pulse wave velocity with some clinical, laboratory and
other p... |
27,959 | [Stroke and other thromboembolic complications of atrial fibrillation. Part VI.
Choice of optimal approach and drugs for prevention of stroke]. | In part VI of a series of papers on epidemiology and drug prevention of stroke
and other thromboembolic complications of atrial fibrillation the authors
analyze data of randomized trials comparing various approaches to the treatment
of atrial fibrillation: cardioversion with subsequent use of antiarrhythmic
drugs f... |
27,960 | [Effect of pacemaker implantation on clinical course of ischemic heart disease
and choice of optimal pacing parameters]. | Effect of cardiac pacing on clinical course of ischemic heart disease was
assessed in 154 patients with class II-IV angina pectoris with implanted
pacemakers. Improvement of symptoms (decrease of number of anginal attacks,
increase of exercise tolerance, reduction of number and doses of antianginal
drugs) occurred ... |
27,961 | [Lipid blood spectrum in patients with amiodarone associated hypothyroidism.
Effect of replacement therapy with L-thyroxine]. | Blood lipid levels were measured in 23 patients with amiodarone associated
hypothyroidism (most of them had ischemic heart disease). Abnormalities of lipid
spectrum were found in 12 of these patients. All 12 patients were subjected to
replacement therapy with l-thyroxine. Compensation of thyroid status was
associat... |
27,962 | [Recognition of actual periods of nocturnal rest from 24-hour heart rate
profile]. | Inability to delineate exactly periods of nocturnal sleep and diurnal
wakefulness during 24-hour blood pressure (BP) monitoring causes reporting of
erroneous BP values for these periods. We suggested a simple mathematical
algorithm for detection of periods of nocturnal rest determined as period of low
values of car... |
27,963 | [Effect of long-term therapy with contemporary drugs on diastolic cardiac
function in patients with chronic heart failure]. | Bisoprolol, carvedilol, enalapril are widely used for the treatment of patients
with chronic heart failure. Definite role in the treatment of these patients is
also played by angiotensin-II receptor blockers. Diastolic left ventricular
function is widely spread among patients with chronic heart failure and its
impo... |
27,964 | [Chronic heart failure in patients with type-2 diabetes]. | Combination of diabetes and chronic heart failure is a frequently occurring
syndrome. We studied interrelationship between state of carbohydrate metabolism,
diabetic nephropathy and level of natriuretic peptide in patients with type 2
diabetes and concomitant chronic heart failure. The study confirmed high
diagnost... |
27,965 | [Protection of rat heart myocardium with a selective Na(+)/H(+) exchange
inhibitor and ischemic preconditioning]. | Aim of this study was to compare effects of BIIB-722, a novel Na(+)/H(+)
exchanger-1 inhibitor, and ischemic preconditioning (IP) on infarct size and
metabolism of area at risk in rats. Regional ischemia was induced by 40-min
occlusion of a diagonal branch of left anterior descending coronary artery
(LAD); it was f... |
27,966 | [Potential of bone marrow mesenchymal stem cells for the treatment of diseases
associated with damage of cardiac tissue]. | Ability of mononuclear and adhesive cells to form differentiated elements of
various tissues and organs in tissue culture in vitro has been studied in
experiments on CBA mice. It has been established that adhesion mesenchymal stem
cells are present in bone marrow. These cells are able to generate muscular,
nervous,... |
27,967 | [Atrial fibrillation: choice of the method of pharmacological cardioversion]. | The paper considers circumstances under which it is expedient or not expedient
to perform cardioversion in patients with paroxysmal or persistent atrial
fibrillation. It contains discussion of benefits, limitations and drawbacks of
electrical and pharmacological methods of cardioversion. American College of
Cardiol... |
27,968 | [Positron emission tomography with (18)F-fluoro-2-deoxyglucose in cardiological
diagnosis]. | This clinically oriented review presents main principles of metabolism of
cardiac muscle, pathophysiology of myocardial hibernation and stunning, as well
as methodological principles of positron emission tomography (PET) of the heart
with (18)F-fluoro-2-deoxyglucose ((18)F-FDG). Diagnostic and prognostic value of
(... |
27,969 | [Combination of prehospital systemic thrombolytic therapy with endovascular
procedures in the treatment of patients with acute myocardial infarction]. | Since July 2002 we have been conducting a study of efficacy of prehospital
thrombolytic therapy combined with subsequent endovascular procedures in the
treatment of patients with acute myocardial infarction. Fifty nine patients
received prehospital fibrinolysis with tissue-type plasminogen activator (TPA,
n=28) or ... |
27,970 | [Assessment of coronary reserve in patients with hypertensive disease and
without hypertrophy left ventricular]. | AIM: To study relationship between coronary reserve and left ventricular
geometry.
METHOD AND MATERIAL: Transesophageal cardiac pacing was carried out in 53
patients with hypertensive disease. Thirty five patients (66%) had left
ventricular hypertrophy which was eccentric in 16 and concentric in 19.
RESULTS: Myocard... |
27,971 | [Structural and functional characteristics of cardiovascular system in elderly
patients with borderline hypertension]. | Structural and functional state of the heart and vessels was studied in elderly
patients with borderline hypertension. Remodeling in these patients was compared
with that in patients of the same age with normal or higher blood pressure
levels. Analysis revealed substantial contribution in remodeling of both age and ... |
27,972 | [Nibentan -- a drug for pharmacological cardioversion of persistent atrial
fibrillation]. | AIM: To assess efficacy of a potassium channel blocker nibentan for
pharmacological cardioversion of persistent atrial fibrillation. Method.
Nibentan (1% solution) was infused intravenously after 3 weeks of warfarin
pretreatment to 31 patients with duration of atrial fibrillation from 4 weeks to
15 months.
RESULTS:... |
27,973 | [Circadian dynamics of heart rate variability in patients with paroxysmal form
of atrial fibrillation]. | Circadian dynamics of heart rate variability (HRV) was studied in patients with
ischemic heart disease (IHD) with paroxysmal atrial fibrillation, with IHD and
stable angina without clinically significant arrhythmia and healthy subjects of
the same age. Special emphasis was placed on spontaneous changes of HRV
param... |
27,974 | [Dynamics of postinfarction left ventricular remodeling during long term use of
perindopril, amiodarone, and beta-adrenoblockers]. | Perindopril was used in 287 patients with left ventricular ejection fraction <
or =40% for 1 year after myocardial infarction either alone (n=53), or in
combination with amiodarone (n=53), metoprolol (n=32), bisoprolol (n=32),
carvedilol (n=32), atenolol (n=32), amiodarone and carvedilol (n=53). According
to echoca... |
27,975 | [Effect of granulocyte-macrophage colony stimulating factor on the function and
regeneration of myocardium in rats with experimental infarction]. | To test the reparative capacity of stromal cells in myocardial infarction, rats
were injected with granulocyte-monocyte-colony stimulating factor (GM-CSF)
(leukomax), a cytokine known by its ability to raise a level of stromal cells in
the blood, during first three days after coronary artery ligation. Only 10 of 17 ... |
27,976 | [Inotropic reactions of myocardium of patients with ischemic heart disease and
rats during use of amiodarone]. | AIM: To study effect of amiodarone on inotropic reactions of myocardium of
patients with ischemic heart disease and rats.
METHODS AND RESULTS: Excitability of rat myocardium has been found to be higher
than that of myocardium of patients. Sarcoplasmic reticulum of myocardium of
rats has greater functional reserve, t... |
27,977 | [Pattern of excitation in isolated heart of hibernator ground squirrel Citellus
undulatus]. | Aim of our study was to measure conduction velocity and pattern of excitation
during hypothermia in hearts of ground squirrels Citellus undulatus, known to be
most resilient hibernators. We imaged electrical conduction in intact isolated
hearts of summer active and winter hibernating ground squirrels at temperatures... |
27,978 | [Changes of cardiac electrophysiological parameters after destruction of
epicardial nervous plexi innervating sinoatrial node]. | Electrophysiological methods were used in experiments on 15 dogs for the study
of topography of right atrial epicardial nerves, their connections with
sinoatrial node, and possibilities of selective surgical denervation of
sinoatrial node. Epicardial nerves were electro-coagulated or cryo-destructed in
ventral, lat... |
27,979 | [The role of mutation in cardiac beta-myosin heavy chain gene in population of
patients]. | One of most widely spread causes of hypertrophic cardiomyopathy (HCMP) is
mutation in cardiac beta-myosin heavy chain gene. Data on contribution of this
mutation to development of HCMP in Russian patients are very limited. We
conducted screening of beta-myosin heavy chain gene for the presence of
mutations in 116 p... |
27,980 | [Heart rate turbulence in patients with ventricular tachy arrhythmias of
noncoronary genesis]. | AIM: To assess parameters of heart rate turbulence in patients with ventricular
extrasystoles (VES).
MATERIAL AND METHODS: Patients with VES during Holter ECG monitoring (n=65, age
1-17 years, 32 girls, 33 boys) including 3 with long QT syndrome, 4 with
catecholaminergic ventricular tachycardia, 1 with arrhythmogeni... |
27,981 | [Dermatological adverse reactions of amiodarone]. | Amiodarone, an iodine -- rich benzofurane derivate, is a highly effective agent
for the prophylaxis and treatment of various cardiac arrhythmias, but it is
associated with numerous side effects. Aim of this study was to elucidate
dermatological adverse effects of therapy with amiodarone. Patients (n=468, mean
age 4... |
27,982 | [Segmental left ventricular function in patients with syndrome X]. | Impulse tissue Doppler study of the left ventricle was carried out in 44
patients with cardiac syndrome X (age 47.15+/-6.27 years) and 46 healthy
volunteers aged 35-55 years. Maximal peak velocities "s", "e", "a", "e/a" ratio
and segmental isovolumic relaxation time "ivrt" were evaluated for each of 18
selected lef... |
27,983 | [Clinical genetic determinants of carbohydrate metabolism disturbances in
patients with hypertension and excessive weight]. | AIM: To elucidate associations of polymorphic markers of PPAR, PPARG2, IRS1,
IRS2 genes with disturbances of carbohydrate metabolism in patients with
hypertension and excessive weight.
MATERIAL: Patients (n=145, 53 men and 92 women, age 40-75 years) with untreated
stage 1 hypertension (systolic BP 140-159 and diasto... |
27,984 | [Anomalous origin of left coronary artery from pulmonary trunk: symptoms,
diagnosis and surgical treatment]. | Anomalous origin of left coronary artery from pulmonary artery is a rare
congenital pathology causing death of most patients because of various
arrhythmia and heart failure. The authors present 4 cases of this anomaly with
description of clinical course, diagnosis and surgical procedures. The first
patient was oper... |
27,985 | [Plasma lipids oxidation in patients with occlusive atherosclerosis of lower
extremities and ischemic heart disease]. | Dynamics of lipoprotein oxidation in blood plasma was studied by Cu-induced
plasma oxidation in 114 patients with atherosclerosis of lower extremities of
various severity with and without ischemic heart disease. Preparedness of plasma
lipoproteins to oxidation in patients was higher than in healthy subjects.
Degree... |
27,986 | [Clinical value of allele variants of cytochrome CYP2C9 gene for anticoagulation
therapy with warfarin]. | Warfarin is metabolized by cytochrome CYP2C9 and its pharmacokinetic properties
depend on structural polymorphisms of CYP2C9 gene. We studied frequencies of
allele variants of CYP2C9 gene and associations of individual reaction to
warfarin intake with genotype of CYP2C9 gene. Population frequencies of
CYP2C9x1, CYP... |
27,987 | [Antioxidant properties of statins]. | Statins block expression of protein subunits of Gi-proteins (p22phox and
gp91phox) which determine oxidase activity of NADPH oxidases and expression of
GTP-ase (NADPH activator). This leads to suppression of activity of prooxidant
enzyme systems (NADPH oxidase, xanthine oxidase, oxidase activity of endothelial
NO-s... |
27,988 | [The place of cardiac glycosides in the treatment of chronic heart failure]. | In a series of papers the authors analyze literature data on the use of cardiac
glycosides for long term treatment of chronic heart failure. Part 1 is devoted
to clinical pharmacology of glycosides with special emphasis on digoxin. In low
doses digoxin produces no substantial effect on contractility of left
ventric... |
27,989 | [Is it necessary to detect insulin resistance for diagnosis of metabolic
syndrome in clinical practice?]. | Metabolic syndrome is widely spread in population especially among subjects with
risk factors of atherosclerosis related diseases. Since 1988 criteria of
metabolic syndrome have undergone substantial transformation. Technical
difficulties related to detection of insulin resistance created obstacles to
application o... |
27,990 | [Evolution of atherosclerosis of the aorta and coronary arteries in practically
healthy men in Moscow for a 40-year period]. | AIM: To assess 40 years evolution of atherosclerosis of the aorta and coronary
arteries among practically healthy Moscow men.
METHODS: We compared results of 2 studies of prevalence and extent (area) of
atherosclerotic lesions in thoracic and abdominal aorta and 2 main coronary
arteries. The studies were conducted i... |
27,991 | [The use of esmolol in patients with myocardial infarction complicated with
acute left ventricular failure]. | Forty patients with acute Q-wave myocardial infarction and Killip class I-II
heart failure were randomized to treatment with esmolol (n=22) or just to
standard therapy (n=18) and followed up for 30 days. Esmolol treated patients
had significantly lower in-hospital mortality (p<0.02), less frequently had
postinfarct... |
27,992 | [Extent and location of lesions in aorta and its main branches in patients with
nonspecific aortoarteritis with various genotypes in the region of major
histocompatibility complex]. | AIM: To elucidate associations between location and extent of lesions of
arterial vascular bed in patients with nonspecific aortoarteritis and presence
of various alleles of DRB1 gene of HLA class II in patients of Russian
ethnicity.
MATERIAL AND METHODS: Ultrasonography, magnetic resonance imaging and computed
tom... |
27,993 | [Cardiorenal syndrome in type 1 diabetes mellitus: the role of endothelial
dysfunction]. | AIM: To elucidate the role of endothelial dysfunction in formation of
cardiorenal syndrome in patients with type 1 diabetes and diabetic nephropathy.
MATERIAL AND METHODS: Sixty patients with type 1 diabetes were divided according
to severity of nephropathy into the following groups: with normal albuminuria
(n=15), ... |
27,994 | [The place of cardiac glycosides in the treatment of chronic heart failure. Part
III. The DIG trial]. | In a series of papers the authors analyze literature data on the use of cardiac
glycosides for long term treatment of chronic heart failure. Data obtained in
prospective placebo controlled trial DIG show that digoxin significantly
increases mortality of all patients with sinus rhythm and intact left
ventricular sys... |
27,995 | [Diagnosis and treatment of pulmonary hypertension: current concepts]. | Pulmonary hypertension is diagnosed when pulmonary artery pressure is above 25
mm Hg at rest and 30 mm Hg during exercise; it can be primary or secondary if
complicates some basic disease. Untreated pulmonary hypertension leads to
progressive right ventricular failure and is associated with high risk of sudden
deat... |
27,996 | [Valve sparing operation in a patient with aneurysm of ascending aorta with
aortic regurgitation and concomitant ischemic heart disease]. | Bentall procedure is considered to be operation of choice for ascending thoracic
aneurysms with aortic regurgitation. The however procedure has some inherent
drawbacks (e.g. need of lifetime anticoagulation because of risk of late
thromboembolic complications). These drawbacks can be eliminated by the use of
valve ... |
27,997 | [Results of clinical trials of a novel glycoprotein IIb-IIIa antagonist framon
in high-risk coronary angioplasty]. | New glycoprotein (GP) IIb-IIIa antagonist preparation framon (Monafram), is the
F(ab')(2) fragment of a monoclonal antibody FRaMon directed against GP IIb-IIIa.
This preparation blocks GP IIb-IIIa binding with fibrinogen and inhibits
platelet aggregation both in vitro and upon intravenous administration. Safety
and... |
27,998 | [Prognostic significance of heart fatty acid binding protein in patients with
non-ST elevation acute coronary syndrome: results of follow-up for twelve
months]. | Value of heart fatty acid binding protein (FABP) for medium term prognosis in
patients with non-ST elevation acute coronary syndrome (NSTEACS) is not well
established.
AIM: To compare prognostic value of FABP levels with those of troponin I (TnI)
and creatine kinase MB (CK MB) activity in patients with NSTEACS.
METH... |
27,999 | [Immunomorphological study of coronary grafts]. | Most patients subjected to coronary artery bypass grafting develop graft
occlusions in some time after successful coronary surgery. Causes of graft
occlusions comprise hyperplasia of intima occurring as a response to release of
cytokines and angiotensin II. Angiotensin II is formed in human body with
participation ... |
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