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27,700 | [The value of transesophageal echocardiography for determination of tactics of
cardioversion of atrial fibrillation]. | Transesophageal echocardiography was carried out in 110 patients before
cardioversion of nonvalvular atrial fibrillation which duration exceeded 2 days.
Twenty thrombi were found in 18 patients (16.4%). Anticoagulant phenindione was
given to these patients for 3 weeks. Patients without thrombus received
intravenous... |
27,701 | [Diagnostic value of heart fatty-acid binding protein in early hospitalized
patients with non ST elevation acute coronary syndrome]. | BACKGROUND: Heart fatty-acid-binding protein (FABP) is supposed to be the most
sensitive biomarker of myocardial necrosis in patients with Q-wave myocardial
infarction (MI) and non-diagnostic ECG during first hours after onset of
symptoms. However, diagnostic value of FABP in patients with non-ST elevation
acute co... |
27,702 | [Diabetic dyslipidemia and pathogenesis of ischemic heart disease]. | BACKGROUND: Type II diabetes is associated with high risk of ischemic heart
disease (IHD), diabetes and IHD have similar risk factors, abdominal obesity as
well as interrelated disturbances of lipid and carbohydrate metabolism play
important roles in pathogenesis of both diseases.
AIM: To elucidate characteristics o... |
27,703 | [Quantitative assessment of right ventricular contractility by contrast
angiography in healthy persons and patients with ischemic heart disease]. | Absence of special programs for quantitative analysis of right ventricular
volumes and function precludes precise evaluation of right ventriculography
data. We used standard programs designed for analysis of left ventriculograms
for evaluation of right ventricular volumes and function in 32 patients without
and 20 ... |
27,704 | [Medical care of persons aged 25-84 years with acute myocardial infarction in
Kaunas in 1996 (ischemic heart disease register data)]. | AIM: To evaluate peculiarities of medical care provided for patients with acute
myocardial infarction (AMI) depending on sex and age in Kaunas in 1996.
METHODS: Kaunas community-based ischemic heart disease register conducted
according to the WHO MONICA Project methodology was the source of the data.
RESULTS: Number ... |
27,705 | [Target organs involvement in arterial hypertension. The role of heredity and
environment (study of twins)]. | AIM: To elucidate relationship between hereditary and environmental factors in
development of target organ damage in hypertension.
MATERIAL AND METHODS: The state of myocardium, central nervous system, blood
vessels (including funduscopic examination) was assessed in 64 pairs of mono-
and dizygous hypertensive twins... |
27,706 | [Heart rate variability in patients with hypertension and type 2 diabetes
treated with long acting calcium antagonists]. | BACKGROUND: Enhanced sympathetic activity is a potential cause of increased risk
of cardiovascular complications during treatment of hypertension and type 2
diabetes.
MATERIAL AND METHODS: Heart rate variability (HRV) was assessed before and after
12-16 weeks of treatment with calcium antagonists in 89 patients with... |
27,707 | [Polymorphisms of angiotensin converting enzyme and angiotensin II type 1
receptors genes and the state of regional hemodynamics in borderline arterial
hypertension in young men]. | Relationship between polymorphisms of ACE and ATR1 genes to morphological and
functional states of cardiovascular system was studied in young men with
borderline hypertension living in north-west region of Russia. Prevalences of
ACE DD and ATR1 AC genotypes were 46 and 54%, respectively. There were no
significant c... |
27,708 | [Efficacy and safety of simvastatin in patients with hypercholesterolemia
(results of a Multicenter Clinical Study)]. | AIM: To assess efficacy and safety of a generic preparation of simvastatin
Vasilip (KRKA) in ischemic heart disease patients with hypercholesterolemia or
combined hyperlipidemia.
MATERIAL: Patients (n=167, age 36-73 years) with ischemic heart disease and
moderate hypercholesterolemia or combined hyperlipidemia.
METH... |
27,709 | [Hemodynamics, electrophysiological parameters of the heart and differential
therapy of attacks of atrial fibrillation in patients with subclinical thyroid
dysfunction]. | Thirty patients with subclinical thyrotoxicosis and 32 with subclinical
hypothyroidism with attacks of atrial fibrillation were investigated. At levels
of thyroid-stimulating hormone below 0.1 or above 10.0 mIU/l average
triiodothyronine and thyroxine levels in patients with subclinical
thyrotoxicosis were 89.6 and... |
27,710 | [Effect of enteral feeding on exercise tolerance and clinical picture in
patients with NYHA class III-IV chronic heart failure]. | AIM: To elucidate efficacy of enteral feeding and the role of small intestine in
pathogenesis of cardiac cachexia in patients with heart failure and reduced body
mass.
MATERIAL: Patients with NYHA class III-IV chronic heart failure and deficient
body mass (n=34). Control group comprised 32 patients.
METHODS: In inte... |
27,711 | [Amiodarone-induced keratopathy]. | Amiodarone is an iodinated benzofuran derivate class III antiarrhythmic that is
a highly effective agent for the prophylaxis and treatment of various cardiac
arrhythmias. Amiodarone induced corneal deposits are the most common reversible
side effects (70-100%) in humans. This study was conducted to determine ocular ... |
27,712 | [Microcirculation in hypertension]. | Changes of microcirculatory vascular bed play important role in pathogenesis of
essential hypertension. All components of the system of microcirculation
including vessels and circulating blood are involved into pathological process.
Resistance to blood flow is mostly formed in this system. Resistance depends on
len... |
27,713 | [Results of endovascular revascularization with the use of stents after coronary
bypass surgery in patients with ischemic heart disease]. | AIM: To compare results of stenting in patients with and without prior coronary
artery bypass grafting (CABG).
METHODS: In 21 patients after CABG stents were implanted both in venous grafts
and native vessels (secondary revascularization) and in 25 patients without
history of CABG native vessels were stented (primar... |
27,714 | [Safety of exercise and dobutamine stress echocardiography (results of 2383
tests)]. | AIM: To elucidate complications and unfavorable side effects of diagnostic
exercise and dobutamine stress echocardiography.
MATERIAL: Results of exercise (n=1969) and dobutamine (n=414, 34% with the use
of atropine) stress echocardiography conducted in 2 centers for diagnosis of
coronary heart disease. Mean age of p... |
27,715 | [Clinical symptoms of erosive and ulcerous lesions of gastroduodenal zone in
patients with unstable ischemic heart disease and the significance of endoscopy
in diagnosis]. | We studied 103 patients with unstable ischemic heart disease and clinical signs
of gastroduodenal injury. Among them 62 (60.2%) patients had moderate gastric
dyspepsia and abdominal pain during first 1-5 days of hospitalization. In 17
(16.5%) cases these clinical symptoms were accompanied with symptoms of
gastroduo... |
27,716 | [Combination therapy with fluvastatin and fenofibrate in ischemic heart disease
patients with combined hyperlipidemia and type 2 diabetes]. | AIM: To assess efficacy of combination therapy with fluvastatin and fenofibrate
in ischemic heart disease (IHD) patients with combined hyperlipidemia and type 2
diabetes.
MATERIAL: Patients with IHD and combined hyperlipidemia with (n=56)) or without
type 2 diabetes (n=30).
METHODS: After 8-week diet period the pati... |
27,717 | [Syndrome of impaired tolerance to dietary fats in coronary heart disease]. | Changes of main lipid and apolipoprotein parameters of lipid transport system
during postprandial hyperlipidemia were studied in subjects without (n=72) and
with (n=167) overt coronary heart disease (CHD) including patients with
noninsulin dependent diabetes (n=48). Tolerance to dietary fat was evaluated by
oral fa... |
27,718 | [Selection of protection regimen of dual-chamber cardiac pacing against
paroxysmal supraventricular tachycardia]. | Criteria of selection of a type of protection against paroxysmal
supraventricular tachycardia were studied in 38 patients with permanent
dual-chamber cardiac pacing. Three types of protection were distinguished.
Criteria for their selection were presence of "pacemaker syndrome", state of
chronotropic function of th... |
27,719 | [Spatial vector electrocardiography: technique, perspectives of use]. | Potentials of the use of computer synthesis of integral electrical vector of the
heart D0 are described. Calculation of spatial angular vector velocity and
linear velocity of its movement along trajectory can be carried out in a
framework of biophysical dipole model. Spatial presentation of vector is
realized and i... |
27,720 | [Mobilization of bone marrow stem cells in the management of patients with heart
failure. Protocol and first results of ROT FRONT trial]. | Mobilization of bone marrow stem cells by granulocyte-colony-stimulating factor
(G-CSF) is considered to be an alternative to invasive transplantation of
autologous myoblasts or stem cells directly into injured cardiac tissue. We have
started a 24 week randomized open study in order to elucidate effects of G-CSF
(f... |
27,721 | [Effect of combined antihypertensive and lipid lowering therapy on the level of
coronary risk and tissue insulin resistance in patients with metabolic
syndrome]. | AIM: To assess effect of combined antihypertensive and lipid lowering therapy on
main characteristics of metabolic syndrome and total coronary risk.
MATERIAL: Seventy five patients with metabolic syndrome aged 40-59 years were
included into an open study with parallel groups in which the following
combinations of li... |
27,722 | [QT interval dispersion and hypertension in different variants of left
ventricular geometry (population study)]. | AIM: To assess relationship between QT dispersion, hypertension, and different
variants of left ventricular geometry (concentric or eccentric hypertrophy,
concentric remodeling).
MATERIAL AND METHODS: Blood pressure measurement, electro- and echocardiography
were used in the study of a random sample of Tallinn popul... |
27,723 | [Clinical manifestations and characteristics of vascular bed involvement in
atherosclerosis of lower extremities in patients with type 2 diabetes]. | Clinical manifestations of arterial insufficiency and characteristics of
vascular damage were compared in 68 patients (54 men, 14 women, mean age
64.5+/-1.1 years) with atherosclerosis of arteries of lower extremities
including 40 patients with type 2 diabetes. Color duplex scanning was used for
assessment of sever... |
27,724 | [Physical exercise and atherosclerosis: dynamic high intensity exercise as a
factor inducing exogenous dyslipidemia]. | Effect of dynamic exercise of various intensity (maximal 100% and submaximal --
80, 70 and 60% of individual maximally tolerated work load) on blood lipids,
lipo- and apolipoproteins (apo) was studied in healthy subjects and patients
with coronary heart disease. Both in healthy persons and patients high intensity
(... |
27,725 | [Effect of atherogenic risk factors on the state of complex intima-media of
common carotid artery]. | AIM: To elucidate relationship between presence of atherogenic risk factors
(dyslipidemia, hypertension, smoking, etc.) and common carotid artery
intima-media thickness.
MATERIAL AND METHODS: Color duplex carotid artery scanning and determination of
blood lipids, lipo- and apolipoproteins were carried out in 160 pat... |
27,726 | [Assessment of coronary reserve in patients after myocardial infarction]. | Clinical data were compared with results of stress tests (veloergometry and
transesophageal cardiac pacing) in 320 patients 1.5-2 months after myocardial
infarction. Severity of angina was classified as functional class 0, I, II, III
and IV in 78 (24.4%), 162 (50.6%), 64 (20%), 12 (3.75%), and 4 (1.25%) patients,
r... |
27,727 | [Is there an alternative to traditional stress tests? (One more time about
transesophageal cardiac pacing)]. | AIM: To assess diagnostic potential of transesophageal cardiac pacing in
patients with ischemic heart disease.
MATERIAL: One hundred patients with overt or suspected ischemic heart disease
(IHD) unable to perform or complete standard exercise test.
METHODS: In addition to clinical investigation and transesophageal ca... |
27,728 | [Blocker of angiotensin-1 receptor antagonist losartan. Part III. Experience in
therapy for chronic heart failure and after acute myocardial infarction]. | This is the third part in a series of papers dealing with various aspects of
clinical pharmacology of the first AT(1)-receptor antagonist losartan and its
therapeutic use in hypertension, diabetic nephropathy, chronic heart failure,
and acute phase of myocardial infarction. This part contains review of
literature d... |
27,729 | [Arterial switch operation in reconstructive surgery]. | Arterial switch is a relatively novel surgical approach aimed at augmentation of
blood flow at the account of less important arterial branches. The method
consists in suturing vessels of different diameter end to end and end to side.
Arterial switch is used for perfusion of donor organs, kidney in particular. The
a... |
27,730 | [Structural and functional changes of the myocardium after coronary artery
bypass surgery in patients with postinfarction left ventricular remodeling]. | In patients with left ventricular end diastolic dimensions >5--< or =5.5 cm
myocardial revascularization was associated with significant decreases of
diastolic and systolic left ventricular dimensions in immediate postoperative
period. This adaptational phenomenon was called passive reducing left
ventricular remode... |
27,731 | [Clinical and hemodynamic characteristics of ischemic heart disease in patients
with deficient body mass]. | AIM: To elucidate clinical and hemodynamic characteristics of patients with
ischemic heart disease and low body mass.
MATERIAL: Patients with stable angina (n=162) divided into 3 groups according to
body mass index (below 25, 25-27 kg/m2 and above 27 kg/m2).
RESULTS: Patients with low body mass index compared with th... |
27,732 | [Dynamics of parameters of left ventricular diastolic function in elderly
patients with myocardial infarction]. | Dynamics of parameters of intraventricular filling flows were studied in 83 men
(46 older and 37 younger than 60 years) admitted within 12 hours after onset of
Q-wave myocardial infarction. Echocardiography was carried out on days 1, 3, 5,
and 21 of hospitalization with registration of standard characteristics of le... |
27,733 | [Efficacy of combined use of fosinopril and propranolol in acute myocardial
infarction]. | Echocardiography, Doppler echocardiography and ECG mapping were used in 40
patients aged 30-70 years with first anterior Q-wave myocardial infarction (MI)
for the study of effects of combination of fosinopril and propranolol (20
patients) in comparison with propranolol alone (20 patients) on hemodynamics and
size o... |
27,734 | [Physical exercise and atherosclerosis: proatherogenic effects of high and
moderate intensity static exercise on blood lipid transport system]. | Effects of high (100 and 80 kg) and moderate (60 kg) intensity static leg
exercise on blood serum lipoproteins and apolipoproteins (apo) A1 and B were
studied in healthy subjects (n=11) and patients with coronary heart disease and
class I angina (n=11). Static leg exercise with loads exceeding 60 kg were
associated... |
27,735 | [Clinical and metabolic effects of cardioselective beta-adrenoblockers nebivolol
and metoprolol in patients with hypertension and ischemic heart disease
associated with type 2 diabetes]. | AIM: To compare efficacy and safety of cardioselective beta-adrenoblockers
nebivolol and metoprolol in patients with hypertension and ischemic heart
disease (IHD) combined with type 2 diabetes.
MATERIAL AND METHODS: Patients with IHD, class II-III angina and moderately
severe compensated or subcompensated type II di... |
27,736 | [Polymorphic markers I/D and G7831A of angiotensin-I-converting enzyme gene and
left ventricular hypertrophy in patients with essential hypertension]. | AIM: To elucidate possible association of angiotensin-I-converting enzyme (ACE)
gene polymorphic markers I/D and G7831A with left ventricular hypertrophy (LVH)
in patients with essential hypertension.
MATERIAL: Patients with essential hypertension (n=123, 37 with and 86 without
LVH, mean age 59.15+/-1.19 years).
MET... |
27,737 | [Twenty-four hour blood pressure rhythm in patients with hypertension and
ischemic heart disease]. | AIM: To elucidate relationship between presence of ischemic heart disease and
24-hour blood pressure (BP) profile.
MATERIAL AND METHODS: Twenty four hour BP index characterizing degree of
nocturnal blood pressure fall was measured in patients with hypertension without
coronary heart disease (n=65, group 1), with hyp... |
27,738 | [Effect of nebivolol on the state of pituitary-gonadal system and lipid
peroxidation in young and middle aged men with hypertension]. | Nebivolol (5-10 mg/day) was given for 12 weeks to 32 patients aged 30-65 years
with mild and moderate hypertension. Parameters of pituitary-gonadal system,
lipid peroxidation and antioxidant system were determined before nebivolol, and
after 1 and 3 months. Normalization of diastolic blood pressure effect was
achie... |
27,739 | [Electrocardiographic picture in patients with congenital defect of atrial
septum operated upon in adult age]. | Electrocardiograms from 30 patients with congenital atrial septal defect
operated upon in adult age were analyzed. One of frequent variants of QRS
configuration in standard leads was SIqIII type. It was observed in 50% of
patients. Most frequent (in 67% of patients) variants of QRS configuration in
lead V1 were rSr... |
27,740 | [Anti-arrhythmic therapy: diagnostic possibilities of signal-averaged
electrocardiography and heart rate variability]. | Effects of monotherapy with class IC, II and III antiarrhythmic drugs on
parameters of signal averaged (SA) ECG and heart rate variability were studied
in 88 patients (mean age 45.6+/-7.8 years). Class IC drugs (ethacizine,
disopyramide) caused worsening of qualitative parameters of SA ECG and
appearance of ventric... |
27,741 | [Angiotensin I receptor antagonist losartan. Part II. Effects in arterial
hypertension and diabetic nephropathy]. | This is the second part in a series of papers dealing with various aspects of
clinical pharmacology of the first AT1-receptor antagonist losartan and its
therapeutic use in hypertension, diabetic nephropathy, chronic heart failure,
and acute phase of myocardial infarction. This part contains review of
literature da... |
27,742 | [Concept of critical stenosis in cardial surgery]. | When stenosis of a large artery reaches about 75% of its lumen blood flow distal
to obstruction abruptly falls and ceases to play decisive role for the region it
supplies. This region survives due to opening of collaterals. This allows to
cross-clamp coronary artery for 20-30 minutes and to create distal anastomosis... |
27,743 | [Markers of inflammation and platelet aggregation in patients with non ST
elevation acute coronary syndrome treated with atorvastatin or pravastatin]. | AIM: To find out whether early use of atorvastatin and pravastatin in patients
with non-ST elevation acute coronary syndrome is associated with rapid changes
of platelet aggregation and plasma levels of markers of inflammation.
MATERIAL AND METHODS: Ninety patients (<24h from pain onset, age 64+/-10 years)
treated w... |
27,744 | [Structural-geometric changes of the myocardium and the state of central
hemodynamics during left ventricular remodeling after myocardial infarction]. | Intergroup analysis of parameters of central hemodynamics in the process of
increase of left ventricular dimensions has shown that changes of pump function
of the heart correspond to stages of left ventricular remodeling after
myocardial infarction. Decreases of ejection fraction and cardiac output occur
in patient... |
27,745 | [Clinical effectiveness and safety of citalopram in patients with depression
after myocardial infarction]. | Citalopram (20 mg/day for 42 days) was given to 20 patients (mean age 54.4+/-2.5
years) with depression after myocardial infarction. This was associated with
substantial antidepressive effect (50% and more lowering of the total score of
the Beck depression questionnaire) in 89% of patients, reduction of number and
... |
27,746 | [Relationship between changes of endothelial vasodilator function, vascular and
cardiac structure and derangements of blood pressure 24-hour profile]. | AIM: To assess relationship between 24-hour blood pressure (BP) rhythm and
structural and functional state of the heart and blood vessels.
MATERIAL AND METHODS: Echocardiography, sonography of carotid artery
intima-media, and assessment of endothelium dependent (flow mediated) and
endothelium independent (nitroglyce... |
27,747 | [Blood pressure 24-hour rhythms and variability in adolescents with
hypertension]. | Twenty-four hour blood pressure (BP) monitoring was used for the study of BP
24-hour rhythms and variability in adolescents with hypertension and their
normotensive counterparts. The data obtained evidenced for active participation
of sympatho-adrenal system in genesis of juvenile hypertension: hypertension was
pre... |
27,748 | [Association of a polymorphic marker C825T of the beta(3) subunit of G-protein
with myocardial hypertrophy in patients with hypertensive disease]. | AIM: To elucidate association of a polymorphic marker C825T of the
beta(3)-subunit of G-protein with myocardial hypertrophy in hypertension.
MATERIAL AND METHODS: Alleles of polymorphic marker C825T of the CNB3 gene were
identified by polymerase chain reaction with subsequent cleavage of the product
by BseDI restric... |
27,749 | [Medico-ecological monitoring of cardiovascular diseases in the urbanized
north]. | Aim of the study was to elucidate relationship between complex effect on
organism of unfavorable ecological factors of high altitudes and course of
ischemic heart disease (IHD) and hypertensive disease in Surgut (Khanty-Mansi
Autonomous District). Five year medico-ecological monitoring established direct
relation b... |
27,750 | [Effects of verapamil on atrial fibrillation spontaneous initiation in the
intact canine heart]. | L-type Ca(2+) current (I(Ca,L)) has been shown to play a crucial role in
initiation of early after depolarization (EAD) in cardiomyocytes. To study the
possible role of EAD in spontaneous initiation of atrial fibrillation (AF), we
tested the effects of L-type Ca(2+) channel blocker verapamil in canine models
of cho... |
27,751 | [Effects of metabolic substrates and mannitol on efficiency of cardioplegic
protection in isolated rat heart]. | The aim of this work was to study rationality of addition of aspartic acid,
phosphocreatine, mannitol and tris(bydroxymethyl) aminomethane (trisamine) to a
sanguineous cardioplegic solution. Isolated perfused rat hearts were subjected
to 40-min normothermic total ischemia and 30-min reperfusion. Cardioplegic
soluti... |
27,752 | [Hereditary factors and left ventricular hypertrophy]. | Left ventricular hypertrophy (LVH) is an independent risk factor for morbidity
and mortality from cardiovascular disease in men and women with hypertension and
in asymptomatic subjects with normal blood pressure. In hypertensive patients it
is a stronger coronary risk factor than casual blood pressure readings.
Cor... |
27,753 | [Angiotensin1-receptor antagonist losartan. Part I. Basic clinical
pharmacology]. | This is the initial part in a series of papers dealing with various aspects of
clinical pharmacology of the first AT(1)-receptor antagonist losartan and its
therapeutic use in hypertension, diabetic nephropathy, chronic heart failure,
and acute phase of myocardial infarction. Mechanisms of action, pharmacological
e... |
27,754 | [Possibilities of stress-echocardiography in diagnostics of pathology of mitral
valve. Part II]. | The paper deals with different aspects of application of stress-echocardiography
for assessment of mitral valve disease (acquired stenosis or insufficiency,
mitral regurgitation due to ischemic heart disease and mitral valve prolapse).
Continuity equation is preferable to pressure half-time and resistance for
estim... |
27,755 | [Non ST elevation acute coronary syndrome. Parameters of fibrinolysis during
short term use of ticlopidine or clopidogrel]. | Whether thienopyridines (ticlopidine or clopidogrel) produce similar effects on
fibrinolysis in patients with non ST elevation acute coronary syndrome (NSTEACS)
was not well elucidated.
AIM: To study changes of parameters of fibrinolysis during short term use of
ticlopidine and clopidogrel in NSTEACS patients treate... |
27,756 | [Autonomic tests in survivors of acute phase of myocardial infarction.
Feasibility, tolerance, and safety]. | In order to assess practicability and safety of simple autonomic tests in
survivors of acute phase of myocardial infarction (MI) attempts to carry out
active orthostatic test, tests with controlled breathing (6 and 15 breaths per
min), and Valsalva maneuver were performed in 210 patients on days 4-11 of MI.
All pat... |
27,757 | [Assessment of antiischemic efficacy of balloon angioplasty, coronary bypass
surgery and conservative therapy after myocardial infarction in patients with
single coronary artery disease. Three year prospective study]. | Efficacy of balloon angioplasty, coronary bypass surgery and conservative
therapy in postmyocardial infarction patients with single coronary artery
disease was assessed in 3 year prospective study. Positive clinical effect
persisted after coronary artery bypass grafting (CABG) in 78 and 73% of patients
and after ba... |
27,758 | [Effect of calcium antagonists verapamil and amlodipine on the risk of
development of atrial fibrillation after coronary artery bypass grafting]. | AIM: To assess effect of calcium antagonists amlodipine and verapamil on the
risk of development of atrial fibrillation after coronary artery bypass surgery.
MATERIAL: Of 74 patients subjected to mammary artery and venous coronary bypass
grafting with the use of cardiopulmonary bypass 19 received amlodipine and 21 - ... |
27,759 | [Surgical treatment of acquired defects and ruptures of interventricular
septum]. | Surgical repair of posttraumatic ventricular septal defects, aortic-right
ventricular fistulas and postinfarction ruptures of interventricular septum was
carried out in 15 patients aged 18-75 years. Methods of radical correction
included suturing, plastic repair with synthetic and autopericardial patches,
and amput... |
27,760 | [Out-of-hospital sudden coronary death: separate acute coronary syndrome or the
mode of death due to ischemic (coronary) heart disease?]. | BACKGROUND: The existing data on the morphological substrate of out-of-hospital
sudden death due to ischemic (coronary) heart disease (IHD) and its relationship
to other acute coronary syndromes are not sufficient and even controversial.
MATERIAL AND METHODS: We analyzed clinical and pathological data from 170 men
w... |
27,761 | [Antiischemic efficacy of trimetazidine in patients with intermittent
claudication and effort angina]. | Male patients (n=42) with atherosclerosis obliterans and stage IIA-III ischemia
of lower extremities combined with class II-III angina pectoris were divided
into 2 groups. Patients of group 1 (n=21) were given simvastatin (10-20 mg/day),
clopidogrel (75 mg/day) and trimetazidine (60 mg/day) for 6 months, those of
g... |
27,762 | [Shortening of PR interval, bradycardia and polymorphic ventricular
tachycardia--clinico-electrocardiografical syndrome with high risk of sudden
death in children]. | AIM: To elucidate clinical and electrocardiographical characteristics of
children and adolescents with malignant idiopathic polymorphic ventricular
tachycardia.
MATERIAL: Patients aged 6-14 years (n=16) with polymorphic bidirectional
tachycardia registered either on standard 12-lead ECG (n=6), or during treadmill
e... |
27,763 | [Humoral markers of endothelial dysfunction in essential hypertension]. | AIM: To elucidate potential markers of endothelial dysfunction and relationships
between humoral and vasoregulatory responses of the endothelium in patients with
essential hypertension.
MATERIAL: Thirty four male patients (mean age 54.4+/-9.2) with I-II degree
hypertension and left ventricular hypertrophy.
METHODS: ... |
27,764 | [Characteristics of hemodynamics and metabolism and structural polymorphisms of
angiotensin converting enzyme and angiotensin II type I receptors genes in women
of childbearing]. | Parameters of systemic and intracardiac hemodynamics, characteristics of
metabolism, and structural polymorphisms of angiotensin converting enzyme (ACE)
and angiotensin II type 1 receptor (ATR(1)) genes were studied in women of
childbearing age and men of the same age both with first degree hypertension.
Women had ... |
27,765 | [PRKAR1A gene mutations in two patients with myxoma syndrome (Carney complex)]. | Carney complex is an autosomic dominant disorder initially described as the
association of cardiac myxomas, spotty skin pigmentation and endocrine
overactivity and considered as a multiple neoplasia and lentiginosis syndrome.
Mutations in the tumor suppressor gene PRKAR1A, coding for the type 1-alpha
regulatory sub... |
27,766 | [Non ST elevation acute coronary syndrome: early use of pravastatin or
atorvastatin is associated with divergent changes of parameters of hemostasis]. | PURPOSE: To find out whether pravastatin and atorvastatin rapidly (in 1-2 weeks)
and similarly affect hemostasis in patients with non-ST elevation acute coronary
syndrome (NSTEACS).
METHODS: Ninety aspirin and heparin treated patients with NSTEACS were
randomized <24 hours from pain onset to open pravastatin 40 mg/d... |
27,767 | [Prognostication of hemodynamic efficacy of surgical correction of chronic
coronary insufficiency based on stress test with nitroglycerine]. | In our previous studies we demonstrated possibility of the use of stress
echocardiography with sublingual administration of nitroglycerine for detection
of viable myocardium. Basing on data about myocardial and cerebrovascular
reserves obtained during nitroglycerine tests we created mathematical model for
predictio... |
27,768 | [Russian study of efficacy and safety of an angiotensin converting enzyme
inhibitor quinapril in patients with hypertension]. | Efficacy and safety of an angiotensin converting enzyme inhibitor quinapril were
assessed in a 12 week study on 258 patients with 1-2 degree hypertension and
various concomitant pathology. The use of quinapril as monotherapy (10-40
mg/day) or in combination with hydrochlorothiazide (12.5 mg/day) was associated
with... |
27,769 | [Isradipine-SRO: antihypertensive efficacy, central and peripheral hemodynamic
effects in patients with hypertensive disease]. | AIM: To assess antihypertensive efficacy of isradipine, to study its effects on
central and peripheral hemodynamics, and to investigate relationships between
state of microcirculation and response to treatment.
MATERIAL AND METHODS: Isradipine was given for 12 weeks to 30 patients (16 men,
14 women, mean age 50.2+/-... |
27,770 | [Ramipril in elderly patients with mild and moderate hypertension. Clinical
efficacy, effect on cerebral blood flow and intellectual functioning]. | AIM: to study different ramipril dosage regimens on cerebral blood flow and
cognitive function in elderly patients with mild to moderate hypertension.
MATERIAL: 30 out-patient hypertensive patients (13 men, 17 women, age 55-75
years, mean 62+1,5).
METHODS: After withdrawal of previous antihypertensive therapy patient... |
27,771 | [Effect of metoprolol CR/XL on remodeling of the heart and cardiac rhythm
disturbances after myocardial infarction in patients with chronic heart
failure]. | Metoprolol succinate was given to 60 patients with class I-III heart failure and
ejection fraction <45% after myocardial infarction. Forty seven patients (mean
age 59.3+/-9.8 years) completed 6 months of therapy. Dynamics of ventricular
arrhythmias was assessed by Holter ECG monitoring, registration of parameters of... |
27,772 | [Effect of drug therapy on frequency of adequate discharges of implanted
cardioverter defibrillator]. | Effect of concomitant antiarrhythmic therapy (amiodarone, sotalol,
beta-adrenoblockers, calcium antagonists) on frequency of adequate discharges of
implantable cardioverter defibrillators was studied in 149 patients. Amiodarone
and sotalol significantly decreased frequency of life threatening arrhythmias
(p=0.018) ... |
27,773 | [Mast cells in normal and diseased heart]. | Mast cells, producing different cytokines, chemokines, proteases, vasoactive
substances and other mediators, are multifunction cells which play an important
role in physiological reactions, as well as in pathological situations. In the
human heart mast cells have been identified at the site of sarcolemma, in
periva... |
27,774 | [Clinical, hemodynamic and neurohumoral effects of long-term therapy of patients
with severe chronic heart failure with beta-adrenoblocker bisoprolol]. | The use of beta-adrenoblockers in conjunction with angiotensin converting enzyme
inhibitors improves quality of life and prognosis of patients with chronic heart
failure. However basic mechanisms of these positive effects in severe heart
failure remain to be elucidated.
METHODS: Patients (n=54) with NYHA class III-I... |
27,775 | [Intraventricular filling flows in assessment of left ventricular diastolic
function in the elderly]. | AIM: To assess effect of old age on Doppler parameters of intraventricular
filling flows.
MATERIAL: Echocardiography with determination of velocity and time of early
diastolic flow propagation, degree of its deceleration, maximal regional
intraventricular flow velocity, and late diastolic interval A-Ar was carried o... |
27,776 | [Relationship between Chlamydia pneumoniae and classical risk factors of
coronary heart disease]. | In order to elucidate relationship between Chlamydia pneumonia infection and
established risk factors of coronary heart disease (hypercholesterolemia,
hyperglycemia, hyperfibrinogenemia, smoking, age) chlamydial IgA and IgG
antibodies were determined by solid phase enzyme immunoassay in 122 patients
with ischemic h... |
27,777 | [Effectiveness of excimer laser coronary angioplasty in treatment of patients
with in-stent restenosis]. | In-stent restenosis (ISR), when treated with balloon angioplasty (PTCA) alone,
has an angiographic recurrence rate of 30-85%. Ablating the hypertrophic
neointimal tissue prior to PTCA is an attractive alternative, however late
outcomes of such treatment have not been fully determined. This multicenter case
control ... |
27,778 | [Reperfusion syndrome after direct myocardial revascularization on beating heart
in patients with ischemic heart disease. Possibilities of prevention with
amlodipine]. | Possibilities of secondary prevention of reperfusion syndrome with amlodipine
was assessed in 46 patients (39 with class III-IV angina after myocardial
infarction and 7 with non ST elevation acute coronary syndrome). Twenty six
patients received basic therapy, in 20 patients this therapy was supplemented
with amlod... |
27,779 | [Non ST elevation acute coronary syndrome. Some characteristics of coagulation
and von Willebrand factor during short term use of ticlopidine or clopidogrel]. | Levels of some markers of coagulation and platelet activation such as
prothrombin fragment 1+2 (F1+2) thrombin-antithrombin complex (TAT) and von
Willebrand factor (vWF), are related to outcome in non ST-segment elevation
acute coronary syndrome (NSTEACS). Effects of thienopyridines ticlopidine and
clopidogrel on a... |
27,780 | [Therapy of patients with arterial hypertension with fixed dose combination of
losartan and hydrochlorothiazide. Effect on 24 hour blood pressure and
left-ventricular hypertrophy]. | Twenty four hour blood pressure (BP) monitoring was carried out and structural
state of left ventricular myocardium assessed in 20 patients with mild and
moderate hypertension before and after 24 weeks of therapy with Hyzaar - fixed
dose combination of losartan (50 mg) and hydrochlorothiazide (12.5 mg).
According t... |
27,781 | [Ionic mechanisms of cardiotropic action of a new class III antiarrhythmic drug
RG-2]. | A perforated patch-clamp analysis of the effect of a novel class III
antiarrhythmic agent RG-2, on voltage-dependent currents was made in rat
ventricular myocytes. In these cells, RG-2 decreased delayed rectifier outward
K(+) current, I(k), in concentration dependent manner with threshold
concentration 0.1 microM/l... |
27,782 | [Left ventricular hypertrophy in hypertension. Part I. Criteria of diagnosis and
prevalence]. | Possibilities of electrocardiography, echocardiography and magnetic resonance
tomography for diagnosis of left ventricular hypertrophy are reviewed and
various criteria of left ventricular hypertrophy compared. Literature data
concerning prevalence of left ventricular hypertrophy in different populations
are presen... |
27,783 | [The problem of assessment of efficacy of antihypertensive therapy using 24-hour
blood pressure monitoring]. | Main advantages of the use of 24-hour blood pressure (BP) monitoring for
assessment of effects of antihypertensive therapy consist in more precise
selection of patients requiring drug treatment and more objective evaluation of
results of therapy. However methodological limitations also exist. Among them
are suscept... |
27,784 | [Results of international study of quality of life of patients with stable
angina treated with nitrates (IQOLAN)]. | Effect of transition from multiple administration of short acting nitrates to
once daily use of isosorbide-5-mononitrate on angina class and quality of life
was studied in 280 patients with stable angina pectoris. Transition to
isosorbide-5-mononitrate was associated with increases of (in units) exercise
tolerance ... |
27,785 | [Parameters of spectral-temporal maps of signal averaged ECG in patients with
ischemic heart disease and chronic heart failure]. | Signal averaged ECG was registered in 57 patients with chronic heart failure due
to ischemic heart disease and either accelerating or stable class III effort
angina. Analysis of parameters of spectral-temporal maps showed that high local
activity in terminal portion of ventricular and atrial complexes reflected
het... |
27,786 | [The role of transesophageal dopplerographical assessment of coronary reserve in
coronary sinus in diagnosis of hemodynamically significant left coronary artery
stenoses]. | AIM: To assess the role of estimation of coronary reserve in coronary sinus by
transesophageal doppler during dipyridamole stress test for diagnosis of
hemodynamically significant left coronary artery stenoses.
MATERIAL: Patients with angiographically proven left coronary artery stenoses
(n=29) and 25 healthy volunt... |
27,787 | [Effect of acetyl-CoA C-acyltransferase inhibitor trimetazidine on parameters of
global and local systolic and diastolic functions of left ventricular myocardium
in patients with combined postinfarction ischemic syndrome]. | AIM: To assess effect of trimetazidine on global and regional systolic and
diastolic left ventricular function in patients with combined postinfarction
ischemic syndrome.
MATERIAL: Patients (n=32) with healed myocardial infarction and signs of global
systolic (ejection fraction 38,5+/-2,7%) and diastolic (EIA=0,88+/... |
27,788 | [Non-ST elevation acute coronary syndrome: changes of parameters of hemostasis
during and after treatment with unfractionated heparin and enoxaparin]. | AIM: To compare changes of parameters of hemostasis in patients with non-ST
elevation acute coronary syndrome (NSTEACS) during and after treatment with
unfractionated heparin (UFH) and low molecular weight heparin (LMWH) enoxaparin.
MATERIAL: Control groups of 2 randomized studies of effects of thienopyridines
in NS... |
27,789 | [Erythrocyte cholesterol content in polycythemia vera: relation to ischemic
heart disease]. | Relative cholesterol content and its distribution between erythrocytes and
plasma were studied in 34 patients with polycythemia vera (PV) both with and
without concomitant coronary heart disease (CHD). Deformability of erythrocytes,
disturbances of microcirculation (blood flow fragmentation, decrease of
capillary d... |
27,790 | [Heart rate control with nebivolol in patients with tachysystolic atrial
fibrillation]. | AIM: To find out whether selective beta-adrenoblocker nebivolol can be used for
heart rate (HR) control in patients with chronic tachysystolic atrial
fibrillation.
MATERIAL: Patients (n=20, 7 men, 13 women, age 47-79 years) with ischemic heart
disease and permanent atrial fibrillation (duration 2.5 months - 11 years... |
27,791 | [Electrophysiological experimental study of a novel class III antiarrhythmic
drug RG-2]. | The electrophysiologic effects of a new drug, RG-2 were studied on anesthetized
open-chest dogs and on rabbit right atrial tissue. RG-2 was manufactured in
Chemical-Pharmaceutical Institute in Moscow. Dogs (n=12) were anesthetized with
sodium pentobarbital (30 mg/kg, i.v.). An ECG lead II, arterial blood pressure,
... |
27,792 | [Endothelin receptor blockers--one more agent for the treatment of pulmonary
hypertension]. | Data on participation of derangements of pulmonary vessel endothelial function
in pathogenesis of pulmonary hypertension served as basis for therapeutic use of
prostanoids, sildenafil, and endothelin(ET) receptor blockers. A first
representative of the latter group - bosentan (nonselective ET-receptor
antagonist) h... |
27,793 | [Metoprolol CR/XL: advanced formulation of a classical beta-blocker]. | Metoprolol is a selective beta(1)-adrenergic antagonist extensively used in
major fields of cardiology since 1975. Metoprolol has proven its efficacy in
reducing cardiovascular events and mortality in patients with hypertension and
coronary heart disease in large clinical trials. Recently developed controlled
relea... |
27,794 | [Current trends of cardiovascular morbidity and mortality of children in Russian
Federation. Structure of cardiac pathology in childhood]. | Analysis of structure and prevalences of cardiovascular diseases among children
and adolescents is presented and recent trends of cardiovascular morbidity and
mortality as well as regional differences in dynamics of these parameters in
this age group are discussed. Current situation is characterized by pronounced
l... |
27,795 | [A novel approach to assessment of individual 24-hour heart rate variability]. | A novel approach to assessment of individual 24-hour heart rate variability
(HRV) has been suggested. This approach allows to compare sequences of RR
intervals with knowingly nonstationary rhythm and to obtain valuable information
on direction (increase or decrease) of HRV changes. The latter was not
achievable by ... |
27,796 | [Dynamics of parameters of variability of processes of repolarization after
transluminal balloon angioplasty in patients with ischemic heart disease]. | AIM: To study dynamics of processes of repolarization after transluminal balloon
angioplasty in patients with ischemic heart disease.
MATERIAL AND METHODS: ECG, Holter ECG monitoring, analysis of parameters of
variability of processes of repolarization, echocardiography and treadmill
stress echocardiography were car... |
27,797 | [Parameters of heart rate variability during bicycle ergometry test]. | Short-term (5 min) heart rate variability (HRV) was studied before and during
submaximal bicycle exercise tests in 27 patients with ischemic heart disease, 23
patients with hypertension and 9 healthy subjects. Low-frequency (0.04 to 0.15
Hz) and high-frequency (0.15 to 0.40 Hz) power components of HRV were
signific... |
27,798 | [Clinical efficacy of myocardial cytoprotector trimetazidine in peri- and
postmenopausal women with ischemic heart disease]. | Efficacy of 3-12 month use of trimetazidine hydrochloride combined with
verapamil was assessed in postmenopausal women with effort angina by repetitive
exercise tests, ECG monitoring and echocardiography. The use of trimetazidine
was associated with augmentation of antianginal and antiischemic action of
verapamil, ... |
27,799 | [Atorvastatin in the treatment of patients with hereditary
hypercholesterolemia]. | Efficacy and tolerability of atorvastatin (20 mg/day) were assessed in a 3 month
study on 19 patients (5 men, 14 women, mean age 52.3 years) with familial
hypercholesterolemia. Average baseline levels of total cholesterol (CH) and low
density lipoprotein (LDL) CH were 10.7 and 8.6 mmol/l, respectively. By the end
o... |
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