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28,700 | Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. | Mild hyperhomocysteinemia is established as an independent risk factor for atherothrombotic disease, including ocular pathologies such as retinal vascular occlusion and non-arteritic ischemic optic neuropathy (NAION). Low intake or low status of B-vitamins explains elevated total homocysteine (tHcy) concentrations only... |
28,701 | Safety and feasibility of subcutaneous low molecular weight heparin for cerebral venous sinus thrombosis. | The effect of low molecular weight heparin (LMWH) in the management of cerebral venous thrombosis (CVT) remains unclear. The present study was performed to determine the safety and feasibility of subcutaneous LMWH, with particular attention to hemorrhagic conversions.</AbstractText>LMWH (nadroparin, 7,500 ICU, every 12... |
28,702 | Comparison of unfractionated heparin vs low molecular weight heparin in the treatment of acute deep vein thrombosis. | To compare the results of unfractionated heparin (UFH) with low molecular weight heparin in the treatment of acute deep vein thrombosis of lower limb.</AbstractText>Randomized control trial.</AbstractText>Bolan Medical Complex Hospital, Quetta from January 2002 to July 2003.</AbstractText>Thirty patients who presented ... |
28,703 | Safety of withholding anticoagulant therapy in patients who have clinically suspected pulmonary embolism and negative results on helical computed tomography. | Several studies have focused on the safety of withholding anticoagulant therapy in patients with negative results on helical computed tomography (CT). However, these studies were either retrospective or had a selection bias, since spiral CT was performed only in selected patients. Moreover, no special attention has bee... |
28,704 | Antiphospholipid syndrome presenting as intracardiac thrombus with pulmonary embolism. | The presence of antiphospholipid antibodies is associated with arterial and venous thrombosis. A young female with initial presentation of dyspnea and cough that lasted for days is reported. A computed tomographic scan of her chest and echocardiography showed features of thrombus formation over the right atrium, compli... |
28,705 | Deep vein thrombosis in a tetraparesic patient with mental retardation: case report and review of the literature. | To report a case of deep vein thrombosis (DVT) in a tetraparesic patient, a member of a population in which DVT is reportedly rare.</AbstractText>A 36-year old tetraparesic resident of a developmental centre suddenly developed swelling of one leg. Her plasma D-dimer level was 751 (normal<500) ng ml-1. A Doppler ultr... |
28,706 | Nonoperative treatment of Achilles tendon rupture: 196 consecutive patients with a 7% re-rupture rate. | The best treatment for acute Achilles tendon rupture is unknown.</AbstractText>We assessed the outcome of nonoperative treatment in 196 consecutive individuals with an acute total Achilles tendon rupture who were followed until healing. The mean duration of treatment in cast or orthosis was 8 weeks. After 4 years, a qu... |
28,707 | Evaluation of D-dimer and factor VIII in cirrhotic patients with asymptomatic portal venous thrombosis. | D-dimer and factor VIII levels raise in advanced cirrhosis. We investigated the behavior and the diagnostic usefulness of D-dimer and factor VIII in cirrhotic patients with asymptomatic portal venous thrombosis. Factor VIII coagulant and D-dimer values were measured in 136 consecutive outpatients with stable cirrhosis ... |
28,708 | Longitudinal evaluation of health plan cost per venous thromboembolism or bleed event in patients with a prior venous thromboembolism event during hospitalization. | To measure the per-event health plan costs for acute and follow-up treatment not directed by a clinical study protocol in a group of commercially insured patients in 2 managed care organizations following an incident hospitalization that included a diagnosis for a venous thromboembolism (VTE) event.</AbstractText>A coh... |
28,709 | [Statins--"21st century aspirin"?]. | Doctors prescribe patients more and more medications. This predominantly affects elderly people. Polypharmacy is more and more frequent and predominantly affects elderly people. It may lead to many harmful and virtually life threatening drug interactions. There is pressing need to investigate new remedies, which would ... |
28,710 | [Frequency and incidence of venous thromboembolism in a general hospital]. | The objective of this study was to determine the frequency and incidence of venous thromboembolism (VTE) in an Argentine universitary hospital. We used a longitudinal, retrospective, observational design. Participants were all over-16 year patients who were discharged or died in clinical, obstetrical and surgical units... |
28,711 | [Spontaneous resolution of branch retinal vein occlusion in cases with non-ischemic macular edema. Significance of a waiting period before considering treatment with vitrectomy]. | <AbstractText Label="OBJECTIVES/METHODS" NlmCategory="OBJECTIVE">It is well established that some patients with branch retinal vein occlusion undergo a spontaneous resolution after a suitable waiting period. We present a series of 22 patients with initial acuity under 0.2 for whom we allowed three months of observation... |
28,712 | A multicentre prospective collection of newly diagnosed glioblastoma patients in Lombardia, Italy. | The objective was to set the basis for a prospective, multicentre data collection on newly diagnosed adult glioblastoma patients diagnosed in Lombardia by means of a common database used by neurological and neurosurgical units of various hospitals, providing epidemiological, therapy and follow-up data. All adult patien... |
28,713 | Multimodal therapy for acute and chronic venous thrombotic and occlusive disease. | Critical deep venous thrombosis and occlusion constitutes a small percentage of patients with venous disease. However, these patients exhibit severe symptomatology including pain and extensive edema that may progress to limb- or life-threatening complications such as phlegmasia cerulea dolens and superior vena cava syn... |
28,714 | Protein Z levels and central retinal vein or artery occlusion. | Central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO) are common disorders associated with risk factors for atherosclerosis. Protein Z is a cofactor for the inactivation of activated factor X (Xa) by the protein Z dependent protease inhibitor. Protein Z deficiency was recently linked to incr... |
28,715 | Budd-Chiari syndrome as the first manifestation of polycythemia vera in young women with inherited thrombophilic state: an aggressive form of myeloproliferative disorder requiring multidisciplinary management. | The Budd-Chiari syndrome (BCS), characterized by the obstruction and occlusion of the suprahepatic veins, is a rare but typical complication occurring in patients with polycythemia vera (PV). We describe three young women who developed BCS as first manifestation of PV, in association with an inherited thrombophilic sta... |
28,716 | Right atrial thrombus in an asymptomatic hemodialysis patient with malfunctioning catheter and patent foramen ovale. | The creation of an accurate functioning arteriovenous fistula has been a long-lasting problem in the hemodialysis setting. In spite of recent guidelines and largely because of the old age of the current dialysis population and a high incidence of diabetes mellitus, atherosclerosis, and related vascular problems, it is ... |
28,717 | Recurrent venous thrombosis with factor V Leiden mutation. | A patient who presented with recurrent venous thrombosis is reported. Following an episode of spontaneous deep vein thrombosis of the lower limb he was started on oral anticoagulant therapy, which he discontinued. He presented with cerebral venous thrombosis and improved partially with anticoagulant therapy. Evaluation... |
28,718 | Postoperative portal and splenic vein thrombosis in children: identification of risk factors. | Postoperative portal and splenic vein thrombosis (PSVT) is a rare but potentially fatal complication after abdominal surgery. We present 2 infants with PSVT after splenectomy and total colectomy, respectively, and also provide a review of the literature. We conclude that clinicians should consider that PSVT might occur... |
28,719 | Deep venous thrombosis in a patient with Behçet's disease and homozygous prothrombin (factor II) G20210A mutation on oral contraceptive pills. | Behçet's disease (BD) is a multisystemic disease of unknown aetiology characterized by chronic relapsing oral aphthous lesions, genital ulcers, uveitis, and vasculopathy of both arteries and veins of all sizes. We present the case of a female patient, with BD on oral contraceptive pills, who sustained deep venous ... |
28,720 | Prevalence of antibodies against oxidised LDL in a cohort of 163 patients with positive anti-phospholipid antibodies and recent thrombosis. | We evaluated the prevalence of anti-beta2-glycoprotein I (a-beta2-GPI), anti-phosphatidylserine/prothrombin (a-PP), anti-prothrombin (a-PT), and anti-oxidised low-density lipoprotein (a-oxLDL) antibodies in a cohort of patients with a recent thrombotic event. Among consecutive sera sent to an autoimmune laboratory for ... |
28,721 | Acute adrenal failure as the heralding symptom of primary antiphospholipid syndrome: report of a case and review of the literature. | Acute adrenal failure is a potentially fatal condition if overlooked. Occasionally, acute adrenal insufficiency may ensue from bilateral adrenal haemorrhage in patients with known antiphospholipid syndrome (APS). APS is characterized by recurrent arterial and venous thrombosis, pregnancy complications and detection of ... |
28,722 | A six-year old with fatal pulmonary embolism. | Pulmonary thromboembolism is rarely recognized in young children, even in hospital settings. All current management decisions for children with deep vein thrombosis (DVT) are directly extrapolated from treatment recommendations for adults with no further validation. We report the case of a 6-y-old child presenting with... |
28,723 | Risk factors for venous thrombosis in Swedish children and adolescents. | To identify prothrombotic risk profiles in children and adolescents referred to a regional coagulation centre in southern Sweden for a first thrombotic event.</AbstractText>One hundred and twenty-eight consecutive children and adolescents (newborn to 20 y) referred for evaluations of a first episode of venous thrombosi... |
28,724 | Cardiac tamponade and pericardial effusion due to venous umbilical catheterization. | We present three cases of neonatal cardiac tamponade due to umbilical venous catheterization, a rare, but potentially fatal complication.</AbstractText>Timely diagnosis was made by echocardiography, and an urgent pericardiocentesis revealed TPN fluid. Perforation of the cardial wall was proven by contrast X-ray showing... |
28,725 | Intravitreal triamcinolone acetonide in patients with macular oedema due to branch retinal vein occlusion: a pilot study. | To evaluate treatment of macular oedema due to branch retinal vein occlusion (BRVO) with intravitreal triamcinolone acetonide.</AbstractText>In a prospective case series, nine patients with macular oedema due to BRVO received an intravitreal injection of 4 mg triamcinolone acetonide. Examination included best-corrected... |
28,726 | Quantitative grading of preretinal neovascularization in adult rats. | To quantify photodynamic venous occlusion-induced preretinal neovascularization with fluorescein isothiocyanate-dextran (FITC-dextran) angiography in adult Sprague-Dawley rats.</AbstractText>Argon green laser was used to ablate retinal veins in the experimental group (24 rats), and applied between the vessels in the co... |
28,727 | Rod and cone a-waves in central retinal vein occlusion. | To evaluate rod and cone a-waves in cases with unilateral central retinal vein occlusion (CRVO).</AbstractText>Scotopic and photopic flash electroretinograms (ERGs) were recorded in seven patients aged 54-84 with unilateral hemorrhagic CRVO. Rod and cone a-waves were analyzed using photoreceptor models, and Rm(p3) (max... |
28,728 | Neonatal hydrothorax following migration of a central venous catheter. | The use of a central venous catheter may occasionally be associated with complications like sepsis, effusions and thrombosis. Migration of the central catheter is an unusual complication that often goes unrecognized. This case report is of a neonate who developed hydrothorax resulting from a migrating central line and ... |
28,729 | Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. | To assess intermittent pneumatic compression (IPC) in the prevention of venous thromboembolism (VTE).</AbstractText>The authors randomly allocated patients with a documented intracerebral hemorrhage (ICH) to elastic stockings (ES) alone or combined with IPC. The primary outcome was a combined criteria assessed at day 1... |
28,730 | Factor V leiden homozygosity, dyspnea, and reduced pulmonary function. | Factor V Leiden homozygosity predisposes patients to deep venous thrombosis and major pulmonary thromboembolism. Consequently, factor V Leiden homozygosity could, via unrecognized repeated minor pulmonary thromboemboli, cause chronic pulmonary disease. We tested the hypothesis that factor V Leiden homozygosity is assoc... |
28,731 | OCT measurements in patients with optic disc edema. | This study investigated the influence of disc edema (DE) caused by inflammatory optic neuropathies or retinal vein occlusions on optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness measurements.</AbstractText>OCT RNFL circle scans centered on the optic disc were made for 13 patients with DE (7... |
28,732 | The effects of oral and transdermal hormone replacement therapy on C-reactive protein levels and other inflammatory markers in women with high risk of thrombosis. | In the estrogen in venous thromboembolism (EVTET) study of 140 women with a history of venous thromboembolism (VTE), oral hormone replacement therapy (HRT) was associated with strong activation of coagulation markers and increased risk of recurrent VTE. No such associations were observed in the estrogen women atheroscl... |
28,733 | Factor V Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase 677T, and population genetics. | Thrombosis results from the interaction between predisposing genetic polymorphisms and acquired risk factors. Two of the main prothrombotic alleles, Factor V (FV) Leiden and prothrombin 20210A, are only encountered among European populations. They are estimated to have arisen about 21,000-34,000 years ago as founding m... |
28,734 | Acute mesenteric ischaemia. | Acute Mesenteric Ischaemia (AMI) is an uncommon vascular emergency where the diagnosis is often difficult and overlooked and delay in diagnosis results in a grave outcome. Although extravascular events like intussusception, volvulus, strangulated hernia and adhesive obstruction in neglected cases can result intestinal ... |
28,735 | Headache and seizure in a young woman postpartum. | A 19-year-old woman, 8 days postpartum, presented to the Emergency Department (ED) with a chief complaint of headache, decreased vision, and agitation. Past medical history was unremarkable. Physical examination was remarkable only for dry mucous membranes, decreased visual acuity, and trace pedal edema bilaterally. Wh... |
28,736 | Surgical complications are the main cause of pancreatic allograft loss in pancreas-kidney transplant recipients. | We examined surgical complications among a group of diabetic type 1 patients (IDDM) with end-stage renal disease (ESRD) who had undergone pancreas-kidney transplantations (PK). Between October 1993 and August 2004, 70 SPK were performed using bladder (n = 14) or enteric (n = 56) drainage. Donors were selected according... |
28,737 | Outcome of 118 pancreas transplants with retroperitoneal portal-enteric drainage. | We have recently described a technique for retroperitoneal pancreas transplantation (RPTx) with portal-enteric drainage (PED). Further experience with 118 RPTx is detailed herein.</AbstractText>Between April 2001 and August 2004, 118 patients underwent RPTx with PED among 125 recipients (94.4%) scheduled for this proce... |
28,738 | Surveillance and rescue of pancreas grafts. | Technical failure rates are higher for pancreas allografts (PA) compared with other solid organs. Posttransplant surveillance and prompt availability of rescue teams with multidisciplinary expertise both contribute to improve this result. We herein report a single institution's experience with posttransplant surveillan... |
28,739 | Venous thromboembolism in renal transplant recipients: high rate of recurrence. | Few data are available on the incidence of venous thromboembolism occurring in renal transplant recipients and optimal duration of oral anticoagulant therapy after thrombotic episode. Our study was performed to evaluate the risk of thrombosis recurrence in patients developing a first episode. Among 484 renal transplant... |
28,740 | A review of the risks and benefits of differing prophylaxis regimens for the treatment of deep venous thrombosis and pulmonary embolism in neurosurgery. | Annually, 2 million people in the United States develop deep venous thrombosis (DVT), and nearly 100,000 sustain fatal pulmonary emboli. Prophylaxis against DVT/pulmonary embolism (PE) is a critical issue, and options include elastic stockings, intermittent pneumatic compression stockings, low-dose unfractionated hepar... |
28,741 | Portal hypertension secondary to myelofibrosis: a study of three cases. | In patients with idiopathic myelofibrosis (IM), portal hypertension (PHT) without thrombosis of the hepatic or splenoportal veins is infrequent.</AbstractText>To ascertain the mechanisms responsible for the development of PHT in IM and their therapeutic implications.</AbstractText>Color Doppler ultrasound with portal f... |
28,742 | Fatal venous thromboembolism associated with different combined oral contraceptives: a study of incidences and potential biases in spontaneous reporting. | Fatal venous thromboembolism (VTE) is a rare complication of combined oral contraceptive (COC) treatment. This study aims to determine incidences of fatal VTE in relation to the type of COC and the percentage of cases reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC). A further aim is to compar... |
28,743 | Analysis of rt-PA infusion in tunnelled dialysis catheters. | Urokinase and streptokinase are commonly used thrombolytic agents for obstructed central venous catheters. Although proven to be efficacious, these agents have the potential to induce fibrin breakdown and streptokinase cannot be used repeatedly due to its allergenic nature. Documented evidence suggests that urokinase i... |
28,744 | Experimental study on relationship between retinal vein occlusion and loss of vitreous gel mass. | To explore the relationship between retinal vein occlusion (RVO) and loss of vitreous gel mass.</AbstractText>An experimental RVO was induced by a photodynamic method in one eye (experimental eye) of 17 chinchilla rabbits. The contralateral eye was used as an untreated control. The changes in vitreous gel mass and liqu... |
28,745 | Thyroid diseases and cerebrovascular disease. | Acute cerebral ischemia has been described in different diseases of the thyroid gland, and not only as a result of thyrotoxic atrial fibrillation and cardioembolic stroke. The purpose of this review is to summarize the studies on the relationship between thyroid diseases and cerebrovascular diseases, discussing the mai... |
28,746 | Considerable differences between methods for plasma D-dimer in the diagnosis of venous thrombosis: increased positive prediction using elevated discriminatory limits. | Four analytical methods for plasma D-dimer have been compared in a group of 82 consecutive patients with suspected venous thrombosis, 22 of whom subsequently received a positive clinical diagnosis. Differences in diagnostic power between methods were observed. In three of the four methods tested, the use of elevated di... |
28,747 | Angiogenesis and hemostasis in hematological neoplasias. | Angiogenesis is essential for tumor growth and metastasis. This is firmly established in solid tumors, but accumulating evidence suggests that this is also an important event in hematological neoplasias. Angiogenesis is therefore a putative target for therapy. The potential application of different angiogenesis inhibit... |
28,748 | Novel technique for suprahepatic vena cava reconstruction in rat orthotopic liver transplantation. | In previous studies, the suture technique and the cuff method were applied to anastomoses of the suprahepatic vena cava (SHVC) in rat orthotopic liver transplantation. However, the anastomosis of SHVC is difficult during transplantation because of the short length of the SHVC. Here, we developed a novel method for anas... |
28,749 | [Standard procedures in hemodialysis shunt surgery]. | Native arteriovenous (AV) fistula are the first choice for primary hemodialysis access. It is essential to save as much vein as possible, and therefore distal AV shunts should be tried first. In patients with diabetes, primary brachiocephalic shunts are indicated and show better results than distal AV fistulae. The maj... |
28,750 | Use of a regional infusion pump to control postoperative pain after an abdominoplasty. | This study presents the clinical results for 20 patients who underwent abdominoplasty. A subset of these patients were given a pain relief system that provides continuous infusion of a nonnarcotic medication directly into the surgical wound to reduce postoperative pain. Whereas patients received a pain pump in addition... |
28,751 | IgG and IgM isotypes of anti-cardiolipin and anti-beta2-glycoprotein i antibodies reflect different forms of recent thrombo-embolic events. | We correlated the distribution and levels of serum anti-cardiolipin (aCL) and anti-beta(2)-glycoprotein-1 antibodies (anti-beta(2)-GPI) of the IgG and IgM isotypes to the clinical spectrum of recent (<6 months) thrombo-embolic events in a cohort of 162 patients. Clinical information was obtained by questionnaires fr... |
28,752 | [Efficacy of repeated hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma with portal vein tumor thrombosis]. | <AbstractText Label="BACKGROUND/AIMS" NlmCategory="OBJECTIVE">The aim of this study is to elucidate the efficacy of repeated hepatic arterial infusion chemotherapy (HAIC) and different chemotherapeutic regimens for treating patients having advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT)... |
28,753 | Hepatic attenuation differences associated with obstruction of the portal or hepatic veins in patients with hepatic abscess. | The purpose of our study was to determine the nature of the association between the attenuation difference of the hepatic parenchyma surrounding an abscess and obstruction of the regional portal vein or of the hepatic vein.</AbstractText>Helical CT scans of 60 patients with hepatic abscess were analyzed for the presenc... |
28,754 | Surgical treatment for rabbits' femoral arteries subjected to gunshot wounds combining with seawater immersion. | To investigate the surgical treatment methods and evaluate the outcome of gunshot wounds combining with seawater immersion in rabbits' femoral arteries.</AbstractText>One hundred healthy New Zealand white rabbits (either sex, 3.14 kg+/-0.61 kg in weight) were randomly divided into a seawater immersion group (n=50) and ... |
28,755 | Placement of transvenous pacemaker and ICD leads across total chronic occlusions. | To establish a method of implantation for device leads across total venous occlusions.</AbstractText>Indications for pacemaker and implantable cardiac defibrillator implantation continue to expand. Chronic venous occlusions are increasingly encountered with lead placement. Some degree of obstruction can be as high as 1... |
28,756 | Differences in stroke care practices between regional and metropolitan hospitals. | A recent audit of stroke care in major Australian metropolitan teaching hospitals showed considerable variation in care practices and uptake of evidence-based therapies. We could find no published data on stroke care practices in regional Australia.</AbstractText>To compare acute stroke care practices at four regional ... |
28,757 | Surgeon and hospital volume and the management of colorectal cancer patients in Australia. | The evidence for a relationship between patient outcomes and clinician and hospital volume is increasing. The National Colorectal Cancer Care Survey was undertaken to determine the management patterns in Australia for individuals newly diagnosed with colorectal cancer in a 3 month period in the year 2000.</AbstractText... |
28,758 | The impact of gender on clinical manifestations of primary antiphospholipid syndrome. | The objective of the study was to determine the clinical differences at diagnosis and during follow-up between male and female patients with primary antiphospholipid syndrome (PAPS). We analysed 68 patients, 30 males and 38 females diagnosed and followed between 1990 and 2003. Patients with antiphospholipid syndrome as... |
28,759 | Coronary angiojet catheterization for the management of dural venous sinus thrombosis. Technical note. | In most cases of deep venous sinus thrombosis, systemic anticoagulation represents the initial treatment of choice for preventing propagation of a clot in the dural sinuses. In patients with deep or extensive venous sinus thrombosis, a combination of treatment modalities may be required including systemic anticoagulati... |
28,760 | Systematic review of endovenous laser treatment for varicose veins. | The safety and effectiveness of endovenous laser treatment (EVLT) for varicose veins are not yet fully evaluated.</AbstractText>Medical bibliographic databases, the internet and reference lists were searched from January 1966 to September 2004. Only case series were available for inclusion in the review.</AbstractText>... |
28,761 | Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. | The aim of this study was to assess whether the synthetic factor Xa inhibitor fondaparinux reduced the risk of venous thromboembolism more efficiently than the low molecular weight heparin dalteparin in patients undergoing major abdominal surgery.</AbstractText>In a double-blind double-dummy randomized study, patients ... |
28,762 | Bleeding prolapsed hemorrhoids as a presentation of ruptured internal iliac artery aneurysm: report of a case. | Internal iliac artery aneurysms (IIAAs) are rare and their concealed location in the pelvis presents a diagnostic challenge. We report a case of a 79-year-old man who presented 12 years after an abdominal aortic aneurysm repair, with signs of prolapse, bleeding, hemorrhoids, and a deep vein thrombosis. His condition ra... |
28,763 | Normal D-dimer concentration is a common finding in symptomatic outpatients with distal deep vein thrombosis. | The D-dimer analysis has been shown to have a high sensitivity and a high negative predictive value for the exclusion of deep vein thrombosis (DVT). However, most D-dimer studies, including recent clinical management studies, are performed without examination of the calf veins and/or performed on patient populations wi... |
28,764 | Association of the protein C promoter CG haplotype and the factor II G20210A mutation is a risk factor for cerebral venous thrombosis. | The factor II G20210A mutation and estrogen treatment are described as risk factors for cerebral venous thrombosis (CVT). We evaluated these known risk factors in a population of CVT patients and investigated the role of a combination of two polymorphisms in the promoter of the protein C gene (PC promoter CG haplotype)... |
28,765 | Management of oral anticoagulant therapy in the real practice of an anticoagulation clinic: focus on atrial fibrillation. | Oral anticoagulant treatment (OAT) is increasingly used for preventing venous thromboembolic and cardiovascular disease. Our study was aimed to evaluate the efficacy and safety of OAT management in a real-practice situation, in particular in non-valvular atrial fibrillation (NVAF) patients. Among 1,596 consecutive unse... |
28,766 | Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. | Elevated factor VIII coagulant activity (FVIII:C) levels (>150 IU/dl) represent a prevalent independent risk factor for venous thromboembolism (VTE). Low-density lipoprotein receptor-related protein (LRP) is involved in factor VIII clearance in vivo, and elevated FVIII:C was a feature of the LRP knockout mouse model... |
28,767 | Cerebral venous and sinus thrombosis: patients with a fatal outcome during intravenous dose-adjusted heparin treatment. | Although anticoagulation (AC) reduces the risk of a fatal outcome or severe disability in patients with cerebral venous and sinus thrombosis (CVST), prognosis of severe cases is still difficult to predict. The authors studied the clinical course of patients with CVST who died despite AC therapy to look for clinical fea... |
28,768 | Achieving normothermia in patients with febrile subarachnoid hemorrhage: feasibility and safety of a novel intravascular cooling catheter. | Fever is common and difficult to control in patients with subarachnoid hemorrhage (SAH). We have previously shown an inverse relationship between fever and outcome in patients with SAH.</AbstractText><AbstractText Label="MATERIALS/METHODS" NlmCategory="METHODS">This was a prospective, single-arm, feasibility trial in w... |
28,769 | Structural and hemostatic activities of a sulfated galactofucan from the brown alga Spatoglossum schroederi. An ideal antithrombotic agent? | The brown alga Spatoglossum schroederi contains three fractions of sulfated polysaccharides. One of them was purified by acetone fractionation, ion exchange, and molecular sieving chromatography. It has a molecular size of 21.5 kDa and contains fucose, xylose, galactose, and sulfate in a molar ratio of 1.0:0.5:2.0:2.0 ... |
28,770 | Favourable medium term outcome following hepatic vein recanalisation and/or transjugular intrahepatic portosystemic shunt for Budd Chiari syndrome. | We report our experience with management of patients with Budd Chiari syndrome over the past two decades. In 1996 we described a novel approach involving recanalisation of hepatic veins by combined percutaneous and transvenous approaches. This was incorporated into an algorithm published in 1999 in which our preferred ... |
28,771 | Efficacy and tolerability of lower-dose topotecan in recurrent ovarian cancer: a retrospective case review. | Topotecan (1.5 mg/m(2)/day for 5 consecutive days of a 21-day cycle) is an established recurrent ovarian cancer treatment, but myelosuppression can be dose limiting. This study evaluates the activity and tolerability of low-dose topotecan in our clinical experience. Case records were reviewed for patients with recurren... |
28,772 | Budd-Chiari syndrome: long-term effect on outcome with transjugular intrahepatic portosystemic shunt. | The long-term outcome of Budd-Chiari syndrome (BCS) with transjugular intrahepatic portosystemic shunts (TIPS) is not well studied. To address this, the records of 47 consecutive patients with BCS evaluated in one center from January 1989 to April 2004, were analyzed.</AbstractText>Seven patients with liver tumors were... |
28,773 | Morbidity of prophylactic inguinal lymphadenectomy with saphenous vein preservation for squamous cell penile carcinoma. | Inguinal lymphadenectomy has an essential role in the cure of patients with inguinal metastasis from penile cancer; however, this procedure is associated with a significant morbidity. In recent years, modified lymphadenectomy with saphenous vein preservation has been postulated to reduce morbidity. Herein, we present o... |
28,774 | Complications and outcomes of single-stage bilateral total knee arthroplasty. | A recent literature review by the senior authors of this study revealed that simultaneous bilateral knee arthroplasty is uncommon and controversial. Reported complications include myocardial infarction, deep venous thrombosis, pulmonary embolus, thromboembolic complications, pseudo-obstruction, postoperative ileus and ... |
28,775 | Screening for thrombophilia in high-risk situations: a meta-analysis and cost-effectiveness analysis. | Laboratory testing for the identification of heritable thrombophilia in high-risk patient groups have become common practice; however, indiscriminate testing of all patients is unjustified. The objective of this study was to evaluate the cost-effectiveness of universal and selective history-based thrombophilia screenin... |
28,776 | [Current conceptions of prophylaxis of venous thrombosis in surgery]. | The article is focused on the topic of venous thrombosis and on the current conception of its prophylaxis. Pathophysiology and incidence of postoperative thromboembolism are described and principles of thromboembolic disease prevention, which are based on conclusions of the 7th Conference of American College of Chest P... |
28,777 | Extra-adrenal pheochromocytoma: an unusual cause of deep vein thrombosis. | We report a case of extra-adrenal pheochromocytoma within the organ of Zuckerkandl that presented initially with a left iliofemoral deep venous thrombosis (DVT). At the time of presentation, the DVT was thought to be idiopathic as no underlying cause was detected. Subsequently, because of a series of medical events, th... |
28,778 | Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. | Resolution of deep venous thrombosis (DVT) is involved in the pathogenesis of postthrombotic syndrome. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that are critical in angiogenesis and tissue remodeling. We hypothesized that MMP-2 and its membrane-bound activator membrane type-1 matrix metallop... |
28,779 | Neovascularization in acute venous thrombosis. | The aim of this study was to describe the phenomenon of arteriovenous fistula (AVF) formation in venous thrombus.</AbstractText>Patients referred to the vascular laboratory for evaluation for deep venous thrombosis were included. Duplex ultrasound scanning was used to detect flow within the thrombus. The flow patterns ... |
28,780 | Endovenous laser treatment combined with a surgical strategy for treatment of venous insufficiency in lower extremity: a report of 208 cases. | We assessed the safety and efficacy of endovenous laser treatment (EVLT) of the saphenous vein combined with a surgical strategy for treatment of deep venous insufficiency in the lower extremity.</AbstractText>Two hundred thirty venous insufficiencies of the lower limbs in 208 consecutive patients (93 men and 115 women... |
28,781 | [Thrombophilia in pregnancy and its influence on venous thromboembolism and recurrent miscarriages]. | Thrombophilia can be defined as a predisposition to thrombosis. Inherited or acquired thrombophilias have been associated with venous thromboembolism and recurrent pregnancy loss. Abnormalities in haemostasis that are associated with clinical thrombophilia include heritable defects, such as mutation in genes encoding a... |
28,782 | Prevalence of heparin-induced antibodies in patients with chronic renal failure undergoing hemodialysis. | Heparin-induced thrombocytopenia (HIT) type II is a serious complication of heparin therapy. It presents initially as thrombocytopenia, and is associated with thrombosis in 20-50% of the cases. HIT is related to the presence of heparin-induced antibodies (HIA), which show specificity for the PF4-heparin (PF4-H) complex... |
28,783 | Diagnostic value of family histories of thrombosis to identify children with thrombophilia. | Thrombophilia screening is a time-consuming and expensive procedure. Information about thromboembolism among relatives may be a simple method to identify those at risk of having thrombophilia. In a cross-sectional clinical study the authors have investigated the role of such family histories to detect children with thr... |
28,784 | Vena cava filters: uses and abuses. | Currently, there are more than 10 permanent and optional retrievable vena cava filters in use in North America and Europe. Indications for inferior vena cava (IVC) filter placement are intuitive and filters are used in patients who have deep venous thrombosis (DVT) and contraindications to anticoagulation, or in patien... |
28,785 | Prophylactic indications for vena cava filters: critical appraisal. | Vena caval filters (VCFs) were developed and initially used for therapeutic indications, primarily to prevent recurrence of pulmonary embolism (PE) or its occurrence in selected cases of deep venous thrombosis (DVT), where risk of PE was very high and anticoagulant therapy (AC Rx) was deemed ineffective, contraindicate... |
28,786 | A unified approach to axillosubclavian venous thrombosis in a single hospital admission. | Spontaneous or effort-related thrombosis of the axillosubclavian vein, termed Paget-Schroetter syndrome, is thought to be related to repetitive upper extremity physical activity, most commonly afflicting young, otherwise healthy, individuals. For the past 25 years, the mainstay of treatment for acute axillosubclavian v... |
28,787 | Ambulation and compression after deep vein thrombosis: dispelling myths. | The traditional dogma of putting mobile patients with acute deep vein thrombosis into bed for several days has been challenged by some studies that showed a better clinical outcome with walking exercises under good compression. Repeated lung scans did not show an increased risk of new pulmonary embolism. There was a fa... |
28,788 | The case for thrombolysis for iliofemoral venous thrombosis. | Deep venous thrombosis and its consequences remain a significant clinical challenge despite advances in the current healthcare system. The use of thrombolytic therapy has played an important role in the management of both arterial and venous thrombotic conditions. In this article, relevant clinical evidence and rationa... |
28,789 | Heparin and other rapidly acting anticoagulants. | Unfractionated heparin, derived from porcine intestine, is the prototype of a rapidly acting anticoagulant. It has been used for over 60 years to arrest or prevent thrombus growth. Low-molecular-weight heparins, available in the last 20 years, are manufactured from unfractionated heparin and have superior dose-response... |
28,790 | The role of inflammation in early and late venous thrombosis: Are there clinical implications? | Venous thrombosis is associated with a significant inflammatory response. Inflammatory cells, adhesion molecules (especially selectins), cytokines, and procoagulant microparticles appear to be associated with the thrombogenic process. Once thrombus forms, inflammatory cells are important to thrombus resolution along wi... |
28,791 | The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests. | Clinical trials increasingly use results of diagnostic tests as surrogate outcomes. Our objective was to answer the following questions: (1) is the parameter measured by the reference standard a valid surrogate? (2) How does the tests accuracy influence the estimate of the treatment benefit on surrogate? (3) Is it poss... |
28,792 | [Comparison of the results of conventional, crossclamp and piggyback technique in liver transplantation]. | The authors evaluate the results of the technical variants of liver transplantion in the first 10 years. They present the technique of conventional and piggyback liver transplantation. Their aim is to compare the outcome of the two surgical implantation techniques. Using the piggyback technique, the need for intraopera... |
28,793 | Prospective evaluation of intravitreal triamcinolone acetonide injection in macular edema associated with retinal vascular disorders. | To evaluate the effect of intravitreal triamcinolone acetonide on visual acuity and macular thickness using optical coherence tomography (OCT) in macular edema associated with various retinal vascular disorders.</AbstractText>This prospective nonrandomized clinical interventional study included 81 eyes (76 patients) co... |
28,794 | Thrombosis, thrombophilia, and thromboprophylaxis in pregnancy. | Normal pregnancy is accompanied by changes in coagulation that have likely evolved to protect women from the bleeding challenges of miscarriage and childbirth. Consequently, pregnant women are at an increased risk of thrombosis. The most important risk factors are thrombophilia and a history of thrombosis. Most thrombo... |
28,795 | Goal-oriented thrombolytic therapy for venous thromboembolic disease. | The goal of a therapeutic intervention should be to positively impact a meaningful patient outcome. Too often, though, efficacy of a treatment is based on a surrogate endpoint. Thrombolytic therapy for venous thromboembolic disease is an example of a treatment whose success is primarily based on radiographic or echocar... |
28,796 | Central venous catheters. Observations on the implantation technique and its complications. | The growing utilization of central venous catheterism is linked to the necessity of treating with an always larger number of hospitalized and nonhospitalized patients. The technological development provided us with different devices and materials for specific indications. In the majority of cases the central venous cat... |
28,797 | Transitional cell carcinoma with metastases to spermatic vein and spermatic cord: PET/CT imaging. | Transitional cell carcinoma of the kidney with venous tumor thrombus is uncommon with only a limited number of cases published in the medical literature. The authors present a case of renal urothelial carcinoma with PET/CT imaging. PET, in addition to the demonstration of tumor thrombus in the left renal vein and infer... |
28,798 | Pulmonary thromboembolism associated with Klippel-Trenaunay syndrome. | Klippel-Trenaunay syndrome (KTS) is a rare congenital anomaly characterized by unilateral limb overgrowth, venous varicosities, and capillary malformations (port wine stains) of the affected limb or limbs. Large venous malformations such as those observed in KTS are rare, and many physicians are unfamiliar with the pot... |
28,799 | Obesity as a risk factor in venous thromboembolism. | Whether obesity is an independent risk factor for pulmonary embolism or deep venous thrombosis has not been fully determined.</AbstractText>We used the database of the National Hospital Discharge Survey to further investigate the potential risk of obesity in venous thromboembolic disease.</AbstractText>The relative ris... |
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