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28,900 | Multivisceral transplantation for diffuse portomesenteric thrombosis in a patient with life-threatening esophagogastroduodenal bleeding. | Portal vein thrombosis is the most common cause of portal hypertension in noncirrhotic patients. Variceal bleeding is difficult to treat in these patients, especially those with prehepatic diffuse portal mesenteric thrombosis. In a patient with refractory esophagogastroduodenal variceal bleeding as a result of diffuse ... |
28,901 | Problems with attempted chorioretinal venous anastomosis by laser for nonischemic CRVO and BRVO. | To report the complications and long-term results of laser-induced chorioretinal venous anastomosis in vein occlusions.</AbstractText>Eight consecutive eyes, 3 with central retinal vein (CRVO) and 5 with branch retinal vein occlusion (BRVO), were observed for up to 5 years after attempted laser-induced chorioretinal ve... |
28,902 | Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease. | Aberrant growth of blood vessels in the eye is a major cause of vision loss, occurring as a complication of diabetic retinopathy, age-related macular degeneration, and retinal vascular occlusions, among others. Whereas in humans, in vivo angiography is routinely used to image such diseases, many animal models of ocular... |
28,903 | Venous thromboembolism prophylaxis in medical patients: future perspectives. | Venous thromboembolism is a common potentially life-threatening complication in acutely ill medical patients. Actually, over 70% fatal episodes of pulmonary embolism during hospitalization occur in non-surgical patients. In the absence of thromboprophylaxis, the incidence of venographically detected deep vein thrombosi... |
28,904 | Portal vein thrombosis after laparoscopic splenectomy: an ongoing clinical challenge. | Portal vein thrombosis (PVT) following open splenectomy is a potentially lethal complication with an incidence of up to 6%. The objective of this report is to describe our management of a recent laparoscopic case, discuss current therapies, and consider antiplatelet therapy for prophylaxis.</AbstractText>Medical record... |
28,905 | Mortality from venous thromboembolism in young Swedish women and its relation to pregnancy and use of oral contraceptives--an approach to specifying rates. | Pregnancy and use of combined oral contraceptives (COCs) are major risk factors for venous thromboembolism (VTE) in young women and we wanted to obtain accurate VTE mortality data overall, by age, associated with the use of COCs and pregnancy.</AbstractText>From the Swedish Cause of Death Register (CDR) we identified w... |
28,906 | Sclerosing panniculitis is associated with pulmonary hypertension in systemic sclerosis. | There have been no reports of patients with sclerosing panniculitis and systemic sclerosis (SSc).</AbstractText>To evaluate the incidence of sclerosing panniculitis in patients with SSc, and to investigate the clinical features of such cases.</AbstractText>In total, 128 patients with SSc treated at our clinic were inve... |
28,907 | Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome. | We report the case of a 57-year-old woman with Budd-Chiari syndrome, hepatocellular carcinoma (HCC), and intrahepatic cholangiocarcinoma (ICC). She underwent partial hepatectomy for HCC in April 2000. After surgery, alpha-fetoprotein (AFP) and protein induced by vitamin K absence II (PIVKA-II) returned to normal levels... |
28,908 | Hyperthyroidism and cerebral venous thrombosis. | The demonstration of an underlying prothrombotic condition in cerebral venous thrombosis (CVT) may have important practical consequences in terms of prevention. Thyrotoxicosis through a hypercoagulable state may be a predisposing factor for CVT. The authors present the cases of 4 patients who developed CVT and hyperthy... |
28,909 | [Compartment syndrome following a hematoma in leg muscles, initially interpreted as deep venous thrombosis]. | An otherwise healthy 48-year-old Caucasian male was admitted to hospital due to suspicion of right calf thrombosis. The symptoms were intermittent thickening and tension of the right calf for four days. There was no history of trauma. Clinical signs and symptoms and a d-dimer of 1.4 (< 0.5 mg/l) indicated deep venou... |
28,910 | A methodological study of computerized venous strain-gauge plethysmography of the upper extremities. | This study was performed to assess the efficiency of computerized strain-gauge plethysmography for evaluation of venous volume (VV) and outflow capacity of the upper extremities and to receive reference values. For this purpose, we investigated 34 healthy controls; 16 males and 18 females with a mean age of 45 years (r... |
28,911 | 4. Cerebral venous thrombosis in pregnancy: a case report. | Sudden unexpected death in many instances comes with stimulating or interesting findings, often in contrast to the history provided. Two cases of sudden death in pregnant females with central venous thrombosis are described, because of their rarity. The incidence, etiological factors, predisposing conditions and the et... |
28,912 | [Sneddon's syndrome and systemic lupus erythematosus with cerebrovascular disturbances and widespread livedo]. | A comparative clinical and instrumental analysis of 97 patients with Sneddon's syndrome (SS), a combination of cerebrovascular ischemic disturbances with widespread livedo, and 12 patients with systemic lupus erythematosus (SLE) with the same combination, has been conducted. Despite the presence of similar features rel... |
28,913 | Patient ethnicity and use of venous thromboembolism prophylaxis. | Patients at highest risk for developing venous thromboembolism include those undergoing major orthopedic surgery. However, physicians vary in their strategies to prevent venous thromboembolism. We evaluated whether the use of venous thromboembolism prophylaxis after orthopedic surgery is related to patient ethnicity.</... |
28,914 | Low levels of vitamin B12 and venous thromboembolic disease in elderly men. | Hyperhomocysteinaemia is a well-known risk factor for venous thromboembolic disease (VTD). However, it is not clear whether homocysteine (Hc) itself or a related metabolite or a cofactor is primarily responsible for VTD. We carried out a case-control study to investigate whether vitamin concentrations that are involved... |
28,915 | Air travel and thrombosis. | The current literature suggests a weak association between long-distance travel and the development of asymptomatic venous thromboembolism (VTE). Most of the data available relate to air travel and suggest that the risk is largely confined to asymptomatic calf vein thrombosis in passengers with additional risk factors ... |
28,916 | Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden. | Two polymorphisms in the endothelial protein C receptor (EPCR) gene, 4600A/G and 4678G/C, have been reported to influence the risk of venous thromboembolism (VTE). The objective of this study was to assess whether these polymorphisms modify the risk of VTE in carriers of factor V (FV) Leiden. We genotyped 295 carriers ... |
28,917 | The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. | During the past decade, the role of inflammation in the pathophysiology of arterial thrombosis has been elucidated. However, comparatively little is known about the relationship between inflammation and venous thrombosis. The aim of this study was to perform a systematic review of clinical studies that have examined th... |
28,918 | Ruling out deep venous thrombosis in primary care. A simple diagnostic algorithm including D-dimer testing. | In primary care, the physician has to decide which patients have to be referred for further diagnostic work-up. At present, only in 20% to 30% of the referred patients the diagnosis DVT is confirmed. This puts a burden on both patients and health care budgets. The question arises whether the diagnostic work-up and refe... |
28,919 | Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis. A retrospective analysis of 408 patients. | Immune mediated heparin induced thrombocytopenia (HIT) is a prothrombotic adverse effect of heparin. However, only a subgroup of patients with HIT develops thromboembolic complications. We aimed to identify risk factors for developing HITassociated thrombosis. We analyzed a registry of patients with clinical suspicion ... |
28,920 | Increased prevalence of factor V Leiden in patients with retinal vein occlusion and under 60 years of age. | Retinal vein occlusion (RVO) is a multifactorial disease involving vessel damage, stasis, viscosity and thrombosis. Conflicting findings on hereditary thrombophilic risk factors have been reported and their impact on RVO features remains to be defined. The aim of the present study was to evaluate the prevalence of here... |
28,921 | Residual venous obstruction in patients with a single episode of deep vein thrombosis and in patients with recurrent deep vein thrombosis. | Residual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE). RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a pe... |
28,922 | A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets. | In the platelet, ATP-gated P2X1 receptors have been reported to amplify functional responses to collagen, however the relative importance of early CCa2+ mobilisation events is unknown. We now report that selective desensitisation of P2X1 receptor activity leads to a major reduction in the initial intracellular Ca2+ res... |
28,923 | Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. | Combined oral contraceptives, oral hormone replacement therapy and thrombophilias are recognised risk factors for venous thromboembolism in women. The objective of this study was to assess the risk of thromboembolism among women with thrombophilia who are taking oral contraceptives or hormone replacement therapy, condu... |
28,924 | [Monitoring anticoagulation by fondaparinux: determination of anti factor Xa-level]. | In contrast to low molecular weight heparin and unfractionated heparin fondaparinux is a selective synthetic factor Xa inhibitor. It was approved for thromboprophylaxis after major orthopaedic surgery three years ago. Because of its excellent bioavailability after subcutaneous application once daily independent of body... |
28,925 | The role of smoking in coagulation and thromboembolism in chronic obstructive pulmonary disease. | Pulmonary embolism and deep vein thrombosis both account for many deaths in stable patients with chronic obstructive pulmonary disease (COPD), and the frequency of these events is higher during COPD exacerbations. The morbidity and mortality from deep vein thrombosis and pulmonary embolism in patients with COPD is not ... |
28,926 | An unusual swelling in the neck. | Venous thrombosis is a fundamental pathological entity. Our patient provides an opportunity to consider etiology in terms of Virchow's classic triad. We also draw attention to the effort syndrome, in which recurrent, vigorous exertion of an upper extremity is thought to produce venous thrombosis by virtue of local endo... |
28,927 | Umbilical arterial thrombosis with vascular wall necrosis: clinicopathologic findings of 11 cases. | Thrombosis of umbilical cord vessels is associated with a high perinatal mortality. Most cases are venous thrombi, arterial thrombi are uncommon. To clarify clinical and pathological features of this entity, we reviewed 11 cases with umbilical artery thrombosis. The gestational ages were 33-40 (mean 36.8) weeks. Three ... |
28,928 | Catheter-related septic thrombophlebitis of the great central veins successfully treated with low-dose streptokinase thrombolysis and antimicrobials.<Pagination><StartPage>11</StartPage><MedlinePgn>11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/1477-9560-3-11</ELocationID><Abstract><Abstract... | Septic thrombophlebitis is an iatrogenic life-threatening disease associated with use of central venous devices and intravenous (IV) therapy. In cancer patients receiving chemotherapy, vein resection or surgical thrombectomy in large central venous lines is time-consuming, can delay administration of chemotherapy, and ... |
28,929 | Hepatocellular carcinoma tumour thrombus in a re-canalised para-umbilical vein: detection by 18-fluoro-2-deoxyglucose positron emission tomography imaging. | This case report describes an unusual site of tumour thrombus in a re-canalised para-umbilical vein, in a patient with hepatocellular carcinoma (HCC) and cirrhosis. The tumour thrombus was suspected on conventional radiography and confirmed using PET imaging, illustrating the complimentary value of structural and funct... |
28,930 | Anti-platelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin. | Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4) bound to heparin. Immunogenicity of heparins differs in that unfractionated heparin (UFH) induces more anti-PF4/heparin antibodies than low-molecular-weight heparin (LMWH) and UFH also causes mo... |
28,931 | [The use of venous thromboprophylaxis in Danish medical departments. A questionnaire survey]. | Our goal was to investigate the use of venous thromboprophylaxis in Danish hospital departments of internal medicine, neurology and intensive care.</AbstractText>All 242 Danish departments/wards received a two-page survey form to complete. Two reminders were sent.</AbstractText>Eighty-two percent responded. Ninety perc... |
28,932 | Elective laparoscopic cholecystectomy for symptomatic gallstone disease in patients receiving anticoagulant therapy. | The safety of laparoscopic cholecystectomy (LC) has been proven in patients with several pre-existing clinical conditions. This study was conducted to evaluate the applicability and safety of elective LC in patients with pre-existing cardiovascular conditions who were receiving anticoagulant treatment.</AbstractText>Be... |
28,933 | [Does antiaggregant therapy have a place in type II heparin-induced thrombocytopenia?]. | We report a case of type II heparin-induced thrombocytopenia, which occurred after heart surgery in a 71-year-old female patient with several cardiovascular risk factors. The diagnosis of heparin-induced thrombopenia was suspected because association of multifocal arterial and venous thrombosis and detection of antipla... |
28,934 | [Pulmonary embolism--complication of proximal deep venous thrombosis in colorectal cancer. Diagnosis and management]. | We present the case of a 57 years old male, without cardiovascular history, with colorectal cancer and proximal deep venous thrombosis, who develops a massive pulmonary embolism. The surgical treatment consists in embolectomy of right ventricle, pulmonary trunk, left and right pulmonary artery. The specifics of the cas... |
28,935 | [Lower limb varicosity in patients, with indication for total knee arthroplasty]. | Preoperative treatment of the peripheral venous pathology in patients with indication for total knee arthroplasty (TKA) would reduce the risk of postoperative deep venous thrombosis (DVT). Between 1997 and 2004, 110 patients were evaluated for TKA. 35 had also varicose veins in the lower limbs. 4 patients were excluded... |
28,936 | Ischaemic stroke: acute-phase drug therapy. Mostly aspirin and heparin. | (1) In the acute phase of ischaemic stroke, antiplatelet or anticoagulant treatments reduce the risk of recurrence and pulmonary embolism, but carry a risk of haemorrhagic transformation. (2) Aspirin has been tested in several placebo-controlled trials and has a positive risk-benefit balance, preventing about 5 deaths ... |
28,937 | Melagatran and ximelagatran: new drug. No real simplification of anticoagulant therapy. | (1) The reference drug for prophylaxis against venous thromboembolism after hip or knee replacement surgery is a low-molecular-weight heparin (LMWH), given subcutaneously for 1 to 5 weeks. Vitamin K antagonists, including warfarin, have similar risk-benefit balances. (2) Subcutaneous melagatran and its oral metabolic p... |
28,938 | Portal vein thrombosis (PVT): a study of 20 non-cirrhotic cases. | Portal and mesenteric venous thrombosis (PVT) is an uncommon disease with serious consequences if not discovered early in order to prevent complications such as variceal bleeding and intestinal ischaemia. The objective of this study was to describe the clinical presentation and outcome of patients with PVT with a view ... |
28,939 | Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. | We previously reported the beneficial effects of combination therapy of interferon (IFN)-alpha/5-fluorouracil (FU) for advanced hepatocellular carcinoma (HCC) with tumour thrombi in the major portal branches. This report describes the results of longer follow-up and includes more than double the number of patients rela... |
28,940 | Endovascular treatment of splenomesenteric-portal vein thromboses during orthotopic liver transplantation. | Extensive splanchnic venous thrombosis in patients undergoing orthotopic liver transplantation (OLT) continues to have a substantial impact on surgical complexity and perioperative morbidity and mortality rates. This report presents an experience in eight patients with splanchnic venous thrombosis treated by means of s... |
28,941 | Evolving management strategies for heparin-induced thrombocytopenia. | New treatment strategies based on the availability of alternative anticoagulants have improved outcomes for patients with heparin-induced thrombocytopenia (HIT). Patients with HIT are at an extreme risk of thrombosis even after the discontinuation of heparin. Maintaining a high degree of awareness and instituting alter... |
28,942 | Current indications for preoperative inferior vena cava filter insertion in patients undergoing surgery for morbid obesity. | Pulmonary embolus is a potentially lethal complication in patients undergoing surgery for morbid obesity. In a select group of patients at high risk for venous thromboembolic events (VTE), we have chosen to prophylactically insert inferior vena cava filters via a jugular percutaneous approach. We propose guidelines for... |
28,943 | [Atypical venous thrombosis and protein S deficiency: report of a case]. | A 29 year old man is admitted for hypovemic shock and abdominal pain. This critical condition was due to a diffuse mesenteric venous thrombosis and intestinal infarction. Five meters of small bowel are resected. Few days later a superficial brachial venous thromboembolism grows to superior cava venous and bilateral pul... |
28,944 | [Acute myocardial infarction complicating primary antiphospholipid syndrome after aspirin and steroids withdrawal]. | A 24-year-old woman, with known antiphospholid antibodies (APS), presented with an acute myocardial infarction (AMI) that occurred three months after delivery. No risk factors for arteriosclerosis and no past history of arterial/venous thrombosis were noted. During pregnancy, aspirin prophylaxis was prescribed and foll... |
28,945 | [Anesthetic management for two cases of living related small bowel transplantation]. | Isolated small bowel transplantation allows patients with irreversible small bowel failure to be weaned from total parenteral nutrition (TPN). We reported the first two cases of anesthesia for living related donor small bowel transplantation in our hospital. They had required long-term TPN. This resulted in thrombosis ... |
28,946 | Sickle cell disease: a multigenic perspective of a single-gene disorder. | Although significant progress has been made in our understanding of sickle cell disease (SCD) and in the development of new therapies, many questions are still unanswered, and a cure remains elusive. This is particularly evident in the clinical heterogeneity of the disease. Studies have shown the importance of high hem... |
28,947 | Genomic medicine and thrombotic risk: who, when, how and why? | Major advances in Human Genome research could significantly change the clinical medical practice, providing new possibilities for both diagnosing and treating common pathologies. Many genetic tests are now commercially available for predicting future risk of common disorders. However, genetic testing has potential bene... |
28,948 | Intravascular synovial sarcoma of the external iliac vein and reconstruction with the superficial femoral vein. | Intravascular synovial sarcoma is a rare neoplasm that arises in large veins of the junctional zone between the proximal leg and lower trunk in adult women. Herein we report the first case of an intravascular synovial sarcoma of the external iliac vein. It was successfully treated with neoadjuvant radiotherapy, radical... |
28,949 | Decreased venous thrombosis with an oral inhibitor of P selectin. | P-selectin inhibition with protein therapeutics such as antibodies or soluble ligands given intravenously can decrease thrombosis in a mouse ligation model of venous thrombosis. In this study, we hypothesized that oral inhibition of P selectin with a novel oral nonprotein inhibitor (PSI-697) would decrease thrombosis a... |
28,950 | The efficacy of a new portable sequential compression device (SCD Express) in preventing venous stasis. | It has been previously shown that the SCD Response Compression System, by sensing the postcompression refill time of the lower limbs, delivers more compression cycles over time, resulting in as much as a 76% increase in the total volume of blood expelled per hour. Extended indications for pneumatic compression have nec... |
28,951 | Antiphospholipid syndrome with anti-prothrombin autoantibodies in a patient with an axial-flow left ventricular assist device. | Autoantibodies to prothrombin, first described almost 50 years ago, are paradoxically associated with thrombosis. Described is an unusual case of fatal hypercoagulability in a patient with multiple arterial and venous thromboembolic complications despite intense anticoagulation while being bridged to transplantation wi... |
28,952 | Bilateral internal jugular vein thrombosis in a child with protein S deficiency. | Internal jugular vein thrombosis is a rare but treatable disorder with most of the reports in the literature related to the adult population. The most common reported cause is iatrogenic trauma to the internal jugular vein and only a few cases have been reported in the paediatric population. We present a case of bilate... |
28,953 | Venous thromboembolism and mortality after hip fracture surgery: the ESCORTE study. | Recent changes in the management of hip fracture surgery patients may have modified the epidemiology of postoperative complications.</AbstractText>We performed an observational study of a cohort of patients undergoing hip fracture surgery to update the epidemiological data on this population. The primary study outcome ... |
28,954 | Lupus anticoagulants and the risk of a first episode of deep venous thrombosis. | We have determined lupus anticoagulants, anti-beta2 glycoprotein I (beta2GPI) and antiprothrombin antibodies in the Leiden Thrombophilia Study, a population-based case-control study designed to determine risk factors for deep venous thrombosis (DVT). Lupus anticoagulant (LAC) was measured in 473 patients and 472 contro... |
28,955 | The risk of thrombosis in patients with acute leukemia: occurrence of thrombosis at diagnosis and during treatment. | Thromboembolism can occur during acute leukemia, especially acute lymphoid leukemia (ALL) treated with L-asparaginase. Yet, most reports are anecdotical and scarce data are available on the risk of thrombosis in acute myeloid leukemia (AML).</AbstractText>To evaluate the risk of thrombosis in patients with acute leukem... |
28,956 | Pathophysiology of the antiphospholipid syndrome. | Antiphospholipid syndrome is a distinct disorder with the clinical features of recurrent thrombosis in the venous or arterial circulation and fetal losses. Its serological marker is the presence of antiphospholipid antibodies in the blood of these patients. The relation between the presence of antibodies against anioni... |
28,957 | New anticoagulants. | The limitations of heparin and warfarin have prompted the development of new anticoagulant drugs for prevention and treatment of venous and arterial thromboembolism. Novel parenteral agents include synthetic analogs of the pentasaccharide sequence of heparin that mediates its interaction with antithrombin. Fondaparinux... |
28,958 | Mechanisms of homocysteine-induced atherothrombosis. | Elevation of plasma homocysteine level is a risk factor for cardiovascular disease, stroke, and venous thromboembolism. It is still uncertain, however, whether hyperhomocysteinemia is a causative factor or a marker of vascular disease. The strongest evidence that homocysteine plays a causal role in atherothrombosis has... |
28,959 | Venous thromboembolism: disease burden, outcomes and risk factors. | The epidemiology of venous thromboembolism (VTE) in the community has important implications for VTE prevention and management. This review describes the disease burden (incidence), outcomes (survival, recurrence and complications) and risk factors for deep vein thrombosis and pulmonary embolism occurring in the commun... |
28,960 | Treatment of venous thromboembolism. | This review on the treatment of patients with venous thromboembolic disease consists of three sections. The first section describes the epidemiology, natural history and reasons for treatment of venous thromboembolism (VTE), as well as a short overview on the evaluation of the use of antithrombotic agents and the spect... |
28,961 | Pancreatic neuroendocrine tumor with portal vein tumor thrombus: PET demonstration. | Tumor thrombus differentiates itself from bland thrombus by its contrast enhancement features on cross-sectional imaging and its intense uptake of F-18 FDG on PET as a result of its hypervascularity and high metabolic neoplastic activity. This PET pattern has been reported in cases of renal cell carcinoma and adrenal c... |
28,962 | Emerging strategies in the prevention of venous thromboembolism in hospitalized medical patients. | Venous thromboembolism (VTE) remains a significant cause of morbidity and mortality in hospitalized patients with acute medical illness. The high prevalence of VTE in this patient population, its clinically silent nature, and associated morbidity and mortality indicate that prophylactic therapy is appropriate in those ... |
28,963 | Risk of catheter-related bloodstream infection with peripherally inserted central venous catheters used in hospitalized patients. | Peripherally inserted central venous catheters (PICCs) are now widely used for intermediate and long-term access in current-day health care, especially in the inpatient setting, where they are increasingly supplanting conventional central venous catheters (CVCs) placed percutaneously into the internal jugular, subclavi... |
28,964 | Assessment of hemostatic risk factors in predicting arterial thrombotic events. | Arterial thrombosis results from endovascular injury and, to a lesser extent, alterations in hemostatic equilibrium. Although multiple hereditary and acquired hemostatic risk factors have been described in the pathophysiology of venous thrombosis, the degree and type of abnormalities that contribute to arterial thrombo... |
28,965 | Cerebral vein and dural sinus thrombosis in elderly patients. | The clinical features and prognosis of cerebral vein and dural sinus thrombosis (CVT) in elderly patients have not been previously described.</AbstractText>In a multicenter prospective observational study, we compared clinical and imaging features, risk factors, and outcome of adult patients aged <65 (young and midd... |
28,966 | Neovascularization after great saphenous vein ablation. | To determine the prevalence, distribution, and flow characteristics of intraluminal neovascularization in patients undergoing great saphenous vein (GSV) endovenous laser (EVLT) or radiofrequency ablation (RFA).</AbstractText>Duplex ultrasound (DU) was performed in patients undergoing EVLT or RFA before, during, and aft... |
28,967 | Free radical generation during chemical depolymerization of heparin. | Low-molecular weight heparins (LMWHs), as compared with unfractionated heparin (UFH), present superior bioavailability, much longer plasma half-life, and lower incidence of side effects. For these reasons, over the past two decades LMWHs have become the drugs of choice for the treatment of deep venous thrombosis, pulmo... |
28,968 | Major bleeding complications in a specialized anticoagulation service. | Major bleeding complications were investigated in 2,460 patients with 3,684 patient-years of warfarin exposure from 2000 to 2003. The most common indications for anticoagulation were atrial fibrillation (30%), venous thromboembolic disease (28%), and mechanical heart valve prosthesis (15%). Eleven patients had 12 nonfa... |
28,969 | Acute cytomegalovirus infection complicated by venous thrombosis: a case report. | CMV-induced vasculopathy and thrombosis have been reported, but they are rare conditions usually encountered in immunocompromised patients. However more and more complications of CMV infections are recognized in immunocompetent patients.</AbstractText>We present a case report of a previously healthy adult with cytomega... |
28,970 | [What explains the increased rate of thromboses among the elderly? Pathophysiological data]. | The incidence of both arterial and venous thrombosis increases with age. The explanation is probably multifactorial, since elderly patients often have several risk factors. Aging per se appears to be an independent risk factor for thrombosis: age-related modifications of the vascular apparatus and blood components cont... |
28,971 | [Age, an independent risk factor for thrombosis. Epidemiologic data]. | The incidence of thrombosis--arterial and venous--increases with age. This is the case for atheromatous diseases, atrial fibrillation and even venous thromboembolic disease. Ischemic heart disease is the most common cause of death in the elderly. Atrial fibrillation, an independent risk factor for cerebral vascular acc... |
28,972 | [Incidence of neuromedical complications during rehabilitation after stroke]. | The aim of the study was to examine the frequency and types of neuromedical complications in stroke rehabilitation depending on the age, sex and time from the onset of stroke.</AbstractText>498 patients after stroke (225 females, 227 males) during inpatient rehabilitation in the Rehabilitation Department at the Provinc... |
28,973 | Undifferentiated intimal sarcoma of large systemic blood vessels: report of 14 cases with immunohistochemical profile and review of the literature. | Intimal sarcoma (IS) is defined as a malignant tumor arising in the tunica intima of large blood vessels. In systemic circulation, the majority of IS develop in the aorta, where close to three fourths of published cases lack specific differentiation and are called undifferentiated intimal sarcomas (UIS). The remaining ... |
28,974 | Livedo reticularis is a marker for predicting multi-system thrombosis in antiphospholipid syndrome. | Livedo reticularis (LR) is a skin vasculopathy that has been frequently described in patients with anti-phospholipid syndrome (APS) and reported to be present in association with valvular heart pathology and strokes (i.e. Sneddon's syndrome).</AbstractText>In a cohort of APS patients we investigated the possible associ... |
28,975 | [Prophylaxis of venous thromboembolism in otolaryngology--head and neck surgery]. | Venous thromboembolic disease (deep vein thrombosis and pulmonary embolism) is a frequent and dangerous complication of surgical procedures. Guidelines considering prophylaxis in patients who have a risk of this complication exist in most surgical specialties. In otolaryngology it is a rare illness but a lack of Polish... |
28,976 | MitoKATP-channel opener protects against neuronal death in rat venous ischemia. | Mitochondrial adenosine triphosphate-dependent potassium (mitoKATP) channels are present in the brain, and several reports have shown their neuroprotective, preconditioning effect against an ischemic insult. The role of mitoKATP channels in the penumbra area has not been studied thoroughly. In a model of venous ischemi... |
28,977 | Age as a risk factor for venous thromboembolism after major surgery. | Postoperative deep venous thrombosis and pulmonary embolism are serious and potentially life-threatening complications that frequently occur after major surgery. Most guidelines for thromboprophylaxis use advancing age as a key component to estimate thromboembolic risk. The reported effect of age on postoperative venou... |
28,978 | Low-molecular-weight heparin for the prevention of postoperative venous thromboembolism after abdominal surgery: a review. | To analyze the effect of low-molecular-weight heparin in abdominal surgery, which carries a significant risk of thrombosis, a risk further increased by cancer.</AbstractText>Searches in EMBASE and PubMed between 1980 and 2004 were conducted to identify studies of thromboprophylaxis in abdominal surgery patients. Sixtee... |
28,979 | Anticoagulation therapy in the antiphospholipid syndrome: recent advances. | The antiphospholipid syndrome is currently best treated with anticoagulation. This review discusses the recent literature addressing the duration, intensity, and appropriateness of anticoagulation or antiplatelet therapy in various clinical subcategories of this syndrome.</AbstractText>Several recent articles reaffirm ... |
28,980 | Subcutaneous unfractionated heparin compared with low-molecular-weight heparin for the initial treatment of venous thromboembolism. | Low-molecular-weight heparin is the preferred choice for the initial treatment of acute, uncomplicated venous thromboembolism. In this context, unfractionated heparin is as safe and effective as low-molecular-weight heparin but requires strict laboratory monitoring. Twice-daily subcutaneous unfractionated heparin is mo... |
28,981 | Hormone replacement therapy and risk for venous thromboembolism: what's new and how do these findings influence clinical practice? | Although an association between hormone replacement therapy and venous thromboembolism has been established, several unanswered questions remain. This review will address additional questions relating to hormone replacement therapy and venous thromboembolism. Does the risk for venous thromboembolism differ according to... |
28,982 | Long-term outcomes of venous thrombosis in children. | Venous thromboembolism has become an increasingly recognized clinical entity in children over the past decade. Recently, important efforts have been made to track post thrombotic outcomes. The present review discusses the knowledge gained from seminal studies in the field over the past decade, with particular emphasis ... |
28,983 | Racial disparities in risk factors for thrombosis. | Until recently, the paucity of characterization of the epidemiology of venous thromboembolism among non-Caucasians has contributed to the misconception that race or ethnicity does not modify disease presentation. This review will describe the previously poorly documented magnitude of venous thromboembolism disease burd... |
28,984 | The performance of quantitative D-dimer assays in laboratory routine. | Assessment of D-dimer in plasma is routinely used for the exclusion of venous thrombosis and the monitoring of hypercoagulability. Little information is available about the performance of D-dimer assays in clinical laboratories examined by external quality assessment schemes. We obtained results from 423 laboratories m... |
28,985 | Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR G677A among 594 thrombotic Jordanian patients. | Venous thromboembolism develops as the result of multiple interactions between non-genetic and genetic risk factors. In order to estimate the frequency of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in Jordanian thrombotic patients, we studied 594 patients admitted to the King Hussein Medical Center... |
28,986 | Morbidity and mortality conference: enhancing delivery of surgery residency curricula. | To determine the exposure of surgical residents to educational subjects contained in the APDS 2000 Curriculum from a weekly Morbidity and Mortality (M&M) conference.</AbstractText>The departmental quality assurance data base was queried for content presented in a residency program's M&M conference. The presenta... |
28,987 | Sharp central venous recanalization by means of a TIPS needle. | The purpose of this study was to perform an alternative technique for recanalization of a chronic occlusion of the left brachiocephalic vein that could not be traversed with a guidewire. Restoration of a completely thrombosed left brachiocephalic vein was attempted in a 76-year-old male hemodialysis patient with massiv... |
28,988 | Clinical significance of IgA anticardiolipin and anti-beta2-GP1 antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome. | The objectives of this study were to estimate the prevalence of IgA anticardiolipin antibodies (aCL) and anti-beta(2)-glycoprotein 1 antibodies (abeta(2)-GP1) in a large number of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (PAPS) and to examine possible associations between t... |
28,989 | Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment. | We recently reported that proteinase-activated receptors type I (PAR-1) are coupled to both negative and positive invasion pathways in colonic and kidney cancer cells cultured on collagen type I gels. Here, we found that treatments with the cell-permeant analog 8-Br-cGMP and the soluble guanylate cyclase activator BAY4... |
28,990 | Venous thromboembolism: past, present and future. | Over the last four decades there have been remarkable advances in the diagnosis and treatment of venous thromboembolism (VTE)-pulmonary embolism (PE) and deep venous thrombosis (DVT). We have moved from no objective documentation to a plethora of ever improving imaging studies. Evolving treatment modalities have reduce... |
28,991 | The approach to massive pulmonary embolism. | Massive pulmonary embolism (PE) is surprisingly common and is not necessarily heralded by dramatic symptoms or signs. The death rate from PE remains high, and the most common cause of mortality is recurrent PE, not cancer. Prevention of recurrent embolism with intensive anticoagulation remains the foundation of therapy... |
28,992 | Treatment of acute deep venous thrombosis and pulmonary embolism: use of low molecular weight heparin. | Over the past decade, the use of low molecular weight heparin (LMWH) preparations has revolutionized the approach to preventing and treating venous thromboembolism. For established deep venous thrombosis, numerous prospective clinical trials have indicated that these drugs are at least as safe and as effective as stand... |
28,993 | Low molecular weight heparins: background and pharmacology. | Low molecular weight heparins (LMWHs) are a class of drugs designed to improve on the therapeutic effects and complications of unfractionated heparin (UH). The two drug types share many structural properties and have multiple mechanisms of action in common. The relative potencies with which the mechanisms are expressed... |
28,994 | The diagnostic approach to deep venous thrombosis. | Accurate diagnosis of deep vein thrombosis is important because untreated deep vein thrombosis can cause death or permanent impairment and because effective treatments are available. The approach to the diagnosis of deep vein thrombosis varies because of differences in local resources and expertise. Duplex ultrasonogra... |
28,995 | Venous thromboembolism: risk factors and prophylaxis. | Venous thromboembolism is a common disease in the community and the most frequent preventable cause of hospital death. Acquired and inherited risk factors for thrombosis have been extensively studied over the past two decades. These factors and the clinical setting allow the stratification of most hospitalized patients... |
28,996 | Behçet's disease. | Behçet's disease (BD) is a systemic disorder characterized by recurrent attacks of acute inflammation. Major symptoms are oral aphthous ulcers, uveitis, skin lesions, and genital ulcerations. Involvement of vessels, gastrointestinal (GI) tract, and central nervous system (CNS) is less frequent but is associated wi... |
28,997 | Risk of retinal vein occlusions in patients treated with rofecoxib (vioxx). | To present patients with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) after application of rofecoxib (Vioxx), a cyclo-oxygenase (COX) 2 inhibitor.</AbstractText>Three patients with sudden decrease in their vision were referred for evaluation and possible treatment.</AbstractText>A 72-y... |
28,998 | A phase II trial of irinotecan, 5-fluorouracil and leucovorin combined with celecoxib and glutamine as first-line therapy for advanced colorectal cancer. | Preclinical and clinical data indicate that cyclooxygenase-2 (COX-2) is a bona fide molecular target for colorectal cancer (CRC). Glutamine may decrease chemotherapy-associated diarrhea. This study was designed to address whether the addition of celecoxib, a COX-2 inhibitor, and glutamine would improve the efficacy and... |
28,999 | The impact of standardized stroke orders on adherence to best practices. | Standardized order templates have been credited with improving care for several common medical conditions. The authors sought to determine whether use of standard orders would be associated with improvement in stroke care.</AbstractText>All patients with a discharge diagnosis of ischemic stroke were identified from sev... |
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