Unnamed: 0 int64 0 2.34M | titles stringlengths 5 21.5M | abst stringlengths 1 21.5M |
|---|---|---|
29,900 | The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels. | Elevated factor VIII (FVIII) levels are a recognized risk factor for venous thrombosis. Recently, family studies suggested that the G allele of the 3951C/G (D1241E) FVIII polymorphism is associated to lower FVIII activity. We investigated in case-control studies both biological effects (FVIII levels and activated prote... |
29,901 | Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models. | The antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold (LK-732, LK-639 and LK-731) and their amidoxime prodrugs (LK-658, LK-633 and LK-730) was studied in comparison to argatroban and nadroparin in two rat models of venous thrombosis, induced either by complete stasis comb... |
29,902 | Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis. | To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI an... |
29,903 | [Lemierre's syndrome]. | Lemierre's syndrome (LS) is an uncommon but potentially life-threatening complication of an anaerobic oropharyngeal infection, affecting young adults and adolescents. The disease is characterised by a septic thrombophlebitis of the internal jugular vein and "metastatic" infections, which can be followed by fulminant se... |
29,904 | [The role of the von Willebrand factor in renal diseases and haemodialysis patients]. | During a period of twenty years, the von Willebrand factor (VWf) biological activity was evaluated in 805 patients with vein thrombosis, diabetes mellitus, chronic renal failure and ischemic heart disease. The examined patients were 168 with vein thrombosis, 129 with diabetes mellitus, 412 with chronic renal failure (C... |
29,905 | Exclusion of venous thromboembolism: evaluation of D-Dimer PLUS for the quantitative determination of D-dimer. | The objective of this study was to evaluate if D-Dimer PLUS (Dade Behring, USA), a rapid fully automated assay, could be used as an initial screening test in the diagnosis of venous thromboembolism (VTE). Samples from 274 consecutive symptomatic patients with suspected pulmonary embolism (n=229; 79% outpatients, 21% in... |
29,906 | Laser lead extraction: is there a learning curve? | Laser extraction of device leads offers an attractive alternative to countertraction and electrosurgical dissection sheath, potentially increasing efficacy and reducing complications. Wider adoption of this technology depends on relative ease of use. We report the experience of a new center to define the "learning curv... |
29,907 | Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis. | The post-thrombotic syndrome is a chronic, poorly understood complication of deep venous thrombosis (DVT).</AbstractText>To evaluate predictors of the post-thrombotic syndrome, including intensity of long-term anticoagulation, and to assess the impact of the post-thrombotic syndrome on quality of life.</AbstractText>Th... |
29,908 | [Bilateral internal jugular vein thrombosis following treatment of laryngeal carcinoma--a case report]. | The authors present the case of bilateral internal jugular vein thrombosis, which was diagnosed in a patient after combined therapy (surgery and radiotherapy) because of laryngeal carcinoma. Thrombosis is the frequent complication and the second largest death cause from neoplasms. In review of the literature the cases ... |
29,909 | Prevention and treatment of deep vein thrombosis and pulmonary embolism in critically ill patients. | Deep vein thrombosis and pulmonary embolism remain common problems in the intensive care unit, with limb- and life-threatening complications that are potentially preventable. The intensive care unit clinician is called on to be vigilant with diagnosis and facile with prevention and treatment of thromboembolic disease (... |
29,910 | The midabdominal TRAM flap for breast reconstruction in morbidly obese patients. | The transverse rectus abdominis myocutaneous (TRAM) flap is ideal for postmastectomy reconstruction but is tenuous in morbidly obese patients. Because of their relatively high incidence of postoperative complications, morbidly obese patients are often not considered candidates for autogenous reconstruction. The midabdo... |
29,911 | Is heparin treatment the optimal management for cerebral venous thrombosis? Effect of abciximab, recombinant tissue plasminogen activator, and enoxaparin in experimentally induced superior sagittal sinus thrombosis. | Based on a newly developed model of reversible superior sagittal sinus (SSS) thrombosis in the rat, we investigated the effect of thrombolytic and anticoagulant treatment on recanalization, brain parenchymal changes, and motor deficits.</AbstractText>Thrombosis of the SSS was induced by topical application of ferric ch... |
29,912 | Splenocaval versus mesocaval shunt with artificial vascular graft for the treatment of Budd-Chiari syndrome. | Budd-Chiari syndrome (B-CS) is a disease with a poor prognosis, and the results of medication are not satisfactory. Surgical treatments are widely used to depress portal hypertension and hypertension of the inferior vena cava. Splenocaval shunt is usually applied to treat intrahepatic portal hypertension, but we used t... |
29,913 | Multislice spiral CT angiography in evaluation of liver transplantation candidates. | Orthotopic liver transplantation has become the treatment of choice for patients with end-stage liver disease. This study was designed to study whether multislice spiral CT angiography (MSCTA) could be used for preoperative evaluation for orthotopic liver transplantation candidates.</AbstractText>Eighty consecutive pot... |
29,914 | Familial homocystinuria. | Two cases of siblings diagnosed as cases of familial homocystinuria are reported. Both the cases have classical presentation of familial homocystinuria including history of dislocation of lens of the right eye. Brother had history of psychomotor retardation while sister had a significant history of deep vein thrombosis... |
29,915 | [Correlation of thrombospondin-1 G1678A polymorphism to stroke: a study in Chinese population]. | To assess whether thrombospondin-1 (THBS-1) gene G1678A polymorphism is associated with stroke.</AbstractText>Samples of venous blood were collected from 1634 patients with stroke, including cerebral thrombosis, lacunar cerebral infarction, and cerebral hemorrhage confirmed by CT or MRI, and sex-, and age-matched 1171 ... |
29,916 | Heparin-induced thrombocytopenia in the pediatric intensive care unit population. | To report the occurrence of heparin-induced thrombocytopenia (HIT), discuss its pathophysiology, and outline an approach to management in the pediatric intensive care unit (ICU) patient.</AbstractText>Retrospective case reports.</AbstractText>Pediatric ICU in a tertiary-care center.</AbstractText>Two pediatric ICU pati... |
29,917 | Portal vein thrombosis complicating appendicitis. | Appendicitis is still the most common acute surgical abdomen all over the world and its complications may be grave. We report an adult case of acute appendicitis complicated by Portal Vein Thrombosis (PVT) and ascending portomesenteric phlebitis treated successfully with antibiotics and anticoagulation with no residual... |
29,918 | Cerebral venous thrombosis: a retrospective multicentre study of 48 patients. | The objective was to describe the clinical features and management of cerebral venous thrombosis (CVT) in non-selected centres. An observational study in 11 neurological departments in NW Italy was carried out from 1995 through 1999 on 38 female and 10 male patients. Mean age: 44.8 years, SD=14.3. Onset: acute in 21 pa... |
29,919 | A systematic review of strategies to improve prophylaxis for venous thromboembolism in hospitals. | To assess the effectiveness of different strategies for increasing the uptake of prophylaxis for venous thromboembolism (VTE) in hospitalized patients through a systematic review of the literature.</AbstractText>Literature databases and the Internet were searched from 1996 to May 2003. Studies of strategies to improve ... |
29,920 | Risk factors for thrombophilia in extrahepatic portal vein obstruction. | Scant information exists on the role of thrombophilia in extrahepatic portal vein obstruction (EHPVO). We studied 65 patients with EHPVO, 500 with deep vein thrombosis (DVT) of the lower limbs, and 700 healthy controls referred for thrombophilia screening, including the search for gain-of-function mutations in genes en... |
29,921 | Venous thromboembolism prophylaxis in medically ill patients and the development of strategies to improve prophylaxis rates. | Venous thromboembolism (VTE) is common but often unrecognized in medically ill patients. Over the past 5 years, three large-scale placebo-controlled trials enrolling a total of 5500 medically ill patients have highlighted the risk of VTE in this group. These trials have helped to define a specific at-risk patient profi... |
29,922 | Phase II study of hepatic intraarterial epirubicin and cisplatin, with systemic 5-fluorouracil in patients with unresectable biliary tract tumors. | Patients with unresectable biliary tract carcinomas have a very poor prognosis. To improve the efficacy and tolerance of the ECF regimen (epirubicin at a dose of 50 mg/m2, cisplatin at a dose of 60 mg/m2, and 5-fluorouracil [5-FU] at a dose of 200 mg/m2 per day by continuous infusion), the authors designed a novel appr... |
29,923 | Derivation and validation of a Bayesian network to predict pretest probability of venous thromboembolism. | A Bayesian network can estimate a numeric pretest probability of venous thromboembolism on the basis of values of clinical variables. We determine the accuracy with which a Bayesian network can identify patients with a low pretest probability of venous thromboembolism, defined as less than or equal to 2%.</AbstractText... |
29,924 | Age of retinal hemorrhages by iron detection: an animal model. | Intraretinal hemorrhages have been found in some abusively injured infants and children. Intraretinal hemosiderin has been proposed as an indication of previous injury. The limits of the accuracy of the proposal have not been established. Experimental central retinal vein occlusion (CRVO) was produced in 20 eyes of adu... |
29,925 | Elevated brain natriuretic peptide and troponin I in a woman with generalized weakness and chest pain. | We report the case of a female patient emergently transferred to our institution with the presumptive diagnosis of myocardial infarction in heart failure given the constellation of symptoms and abnormal laboratory cardiac markers on presentation. However, on closer examination, prior to instituting an invasive cardiac ... |
29,926 | Difference in absolute risk of venous and arterial thrombosis between familial protein S deficiency type I and type III. Results from a family cohort study to assess the clinical impact of a laboratory test-based classification. | Hereditary protein S (PS) deficiency type I is an established risk factor for venous thromboembolism. Contradictionary data on type III deficiency suggests a difference in risk between both types. We studied 156 first degree relatives (90% of eligible relatives) from type I deficient probands (cohort 1) and 268 (88%) f... |
29,927 | Ximelagatran--a promising new drug in thromboembolic disorders. | Ximelagatran is an oral direct thrombin inhibitor (DTI), the active form of which is melagatran. Approximately 20% of an oral ximelagatran dose becomes bioavailable as melagatran, which binds noncovalently and reversibly to both fibrin-bound and freely circulating thrombin. Oral ximelagatran dosing not only inhibits th... |
29,928 | Intracoronary brachytherapy--clinical state and pathophysiological considerations. | In-stent restenosis remains the limitation of coronary stent implantation despite numerous efforts of its prevention by catheter-based techniques or by drug therapy. Today, only intravascular irradiation has proven to effectively reduce neointima formation, restenosis rate and major adverse cardiovascular events by app... |
29,929 | Fondaparinux. | Fondaparinux is the first drug from the pentassaccharide factor X inhibitor class of anticoagulants to be approved for clinical use. It has been shown to be effective in the prevention of deep vein thrombosis in patients undergoing major orthopaedic surgery of the lower limbs. The drug is also being evaluated for use i... |
29,930 | Fondaparinux sodium compared with enoxaparin sodium: a cost-effectiveness analysis. | Patients undergoing major orthopedic surgery face considerable risk of venous thromboembolism (VTE), which may be fatal unless they receive prophylactic treatment. Fondaparinux sodium is a new antithrombotic agent that is indicated for prophylaxis of VTE after major orthopedic surgery. This paper presents a cost-effect... |
29,931 | [Guidelines for dialysis. Replacement therapy for acute renal failure in critically ill patients]. | Acute renal failure (ARF) in patients admitted to the intensive care unit (ICU) is mostly caused by ischemic or toxic injury, with a higher incidence in the latest years due to the growing number of interventions in cardiac and vascular surgery and to the general enhancement of reanimation techniques, which allow a bet... |
29,932 | [Thrombosis and cancer]. | Venous thromboembolic disease is a serious complication in patients with cancer. Although its incidence is not well known, the association between thromboembolic disease and cancer is frequent and is in itself an emergency. Facing clinical manifestations compatible with thromboembolic disease, it is imperative to elabo... |
29,933 | Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment. | Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired genetic disorder of the bone marrow that produces intravascular hemolysis, proclivity to venous thrombosis, and hematopoietic failure. Mutation in the PIG-A gene in a stem cell aborts synthesis of glycosyl-phosphoinositol (GPI) anchors and therefore expression of... |
29,934 | Potential impact of oral contraceptive choice on myocardial infarction mortality and deep vein thrombosis. | To summarise the epidemiological evidence on the relationship between second- (OC2) and third-generation (OC3) oral contraceptives (OC) and the mortality associated with deep vein thrombosis (DVT) and myocardial infarction (MI), and to extrapolate and balance the evidence for these risks to the population of French OC ... |
29,935 | Systematic review of thromboprophylaxis in colorectal surgery -- an update. | The incidence of thromboembolism after colorectal surgery is higher than after general surgery. The aim of this paper is to update a systematic review addressing thrombosis prophylaxis in connection with colorectal surgery.</AbstractText>MEDLINE, EMBASE, LILACS, abstract books and reference lists from reviews were sear... |
29,936 | Quality of stroke care within a hospital: effects of a mobile stroke service. | An Australian stroke services study (SCOPES) has developed a framework to compare different forms of acute stroke services, the gold standard being localised stroke units. We aimed to use this framework to assess changes in the quality of stroke care over time as a sequential audit process.</AbstractText>A retrospectiv... |
29,937 | The prevalence of venous thromboembolism after hip and knee replacement surgery. | To determine the prevalence of venous thromboembolism (VTE) after total hip replacement (THR), total knee replacement (TKR) or bilateral TKR in a large sample of patients in a major hospital orthopaedic unit.</AbstractText><AbstractText Label="DESIGN, SETTING AND PATIENTS" NlmCategory="METHODS">The Mater Misericordiae ... |
29,938 | Prevention of catheter thrombosis increases survival, but does not modify lung injury in rats receiving long-term parenteral nutrition. | It has previously been shown that rats receiving total parenteral nutrition (TPN) or each component of TPN die within 40 days of treatment. Central catheter thrombosis and lung injury were constant findings. The aim of the present study was to examine the impact of central thrombosis on lung injury and survival in rats... |
29,939 | [Radial optic neurotomy in ischemic central retinal vein occlusion]. | Loss of visual acuity due to ischemic retinal vein occlusion (RVO) is still a major problem in ophthalmology. Prognosis is poor and loss of vision is a severe risk. New approaches for treatment like systemic fibrinolysis and surgical procedures have been suggested.</AbstractText>In a clinical trial 8 patients with isch... |
29,940 | [Characterization of an experimental venous thrombus model with MRI, phlebography and histology]. | Several magnetic resonance (MR) techniques designed to demonstrate the characteristic signal intensity of blood degeneration products of thrombi have been suggested, but the effect of thrombus organization on the MR display, in particular with regard to its temporal evolution, remains to be determined. It is the purpos... |
29,941 | Unusual case of mesenteric venous thrombosis associated with oral contraceptive use in an adolescent girl. | A 16-year-old girl presented with hematochezia and abdominal pain. The patient developed a small bowel obstruction that required a laparotomy, which showed a segment of grossly infarcted small bowel with 3 perforations, localized abscesses, and creeping fat. Resection and an end-to-end anastomosis were performed. Patho... |
29,942 | The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation. | The human prothrombin G20210A polymorphism located at the 3' cleavage site of the mRNA results in elevated plasma prothrombin levels and increased risk of venous thrombosis. This polymorphism has been shown to directly influence a variety of processes related to prothrombin mRNA metabolism. We have constructed plasmids... |
29,943 | A review of medical records and discharge summary data found moderate to high predictive values of discharge diagnoses of venous thromboembolism during pregnancy and postpartum. | To validate the discharge diagnoses of venous thromboembolism during pregnancy and postpartum, we examined the positive predictive value (PPV) of venous thromboembolic (VTE) discharge diagnoses associated with pregnancy or puerperium based on 311 cases registered in a Danish population-based hospital-discharge registry... |
29,944 | [Upper limb deep venous thrombosis. Risk factors, outcome, and posthrombotic syndrome]. | Our objective was that of describing a series of episodes of upper limb deep venous thrombosis, with special emphasis on the incidence of posthrombotic syndrome and its impact in the quality of life of the patients.</AbstractText>33 episodes (29 patients) of upper limb deep venous thrombosis were studied, between Janua... |
29,945 | [Detection of deep vein thrombosis in preoperative patients using venous ultrasonography]. | Using Doppler ultrasonography (US), deep vein thrombosis (DVT) has been detected in the lower limbs of preoperative patients.</AbstractText>Of 1,087 patients scheduled for surgery from January to June 2002, US was performed in 85 patients with a history of thromboembolism, a presence of abnormality in the lower extremi... |
29,946 | Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis. | Thrombophilic gene mutations have been reported to be associated with the formation of portal vein thrombosis (PVT). This study aimed to investigate the role of thrombophilic gene mutations in cirrhotic patients with PVT.</AbstractText>A total of 74 cirrhotic patients (17 with PVT, 57 without PVT), and 19 non-cirrhotic... |
29,947 | Retroperitoneal laparoscopic radical nephrectomy for renal cell carcinoma with infrahepatic vena caval thrombus. | The retroperitoneal laparoscopic approach is utilized to treat a right renal tumor with vena caval thrombus reaching infrahepatic veins.</AbstractText>The patient is an 87-year-old woman with a tumor measuring 8 x 9 cm and a vena caval thrombus (7 cm), stretching as far as the subhepatic vein. The retroperitoneal lapar... |
29,948 | Intravitreal triamcinolone acetonide in patients with macular oedema due to central retinal vein occlusion. | To evaluate treatment of macular oedema due to central retinal vein occlusion (CRVO) with intravitreal triamcinolone acetonide.</AbstractText>In a prospective case series, 13 patients with macular oedema due to non-ischaemic CRVO received an intravitreal injection of 4 mg triamcinolone acetonide. Examination included a... |
29,949 | [Case of a young woman successfully operated on for acute pulmonary embolism and right ventricular thrombus after urogenital infection]. | The authors report a case of a 22-year-old women operated on for pulmonary embolism with success. The venous embolism developed in two phases one week apart. The first clinical sign was a dyspnea of abrupt onset limiting physical activity even after a mild exertion. However, relevant diagnostic tests were performed aft... |
29,950 | Nurse's guide to understanding and treating thrombotic occlusion of central venous access devices. | Over 5 million central venous access devices (CVADs) are placed in the United States annually. Catheter occlusion is the most common non-infectious complication in long-term use of CVADs. Nursing management of the thrombotic occlusion of central venous access devices is described. The normal process of hemostasis and f... |
29,951 | Acute thrombosis of inferior vena cava in a pregnant woman presenting with sciatica: a case report. | A 20-year-old pregnant woman was admitted to our department with symptoms of deep venous thrombosis in the left lower extremity and excessive lumbar pain. Low-molecular-weight heparin was administered. She recovered with this treatment, however, severe lumbar pain continued. A lumbar magnetic resonance image showed dil... |
29,952 | Comparing short-term outcomes of femoral-popliteal and iliofemoral deep venous thrombosis: early lysis and development of reflux. | This study compares the development of reflux, recanalization, and clinical outcomes of patients with femoral-popliteal and iliofemoral deep venous thrombosis (DVT). Emphasis is placed on the relationship between early lysis of clot through thrombolysis and the development of reflux and post-thrombotic syndrome (PTS) f... |
29,953 | Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study. | The Protein S Italian Team (PROSIT) enrolled 79 protein S (PS) deficient families and found 38 PROS1 variations (19 novel) in 53 probands. Of these, 23 variants were selected for expression in'vitro, to evaluate their role as possible causative variants. Transient expression showed high secretion levels (>75%) for t... |
29,954 | Ultrasound elastography for the age determination of venous thrombi. Evaluation in an animal model of venous thrombosis. | The exact age determination of venous thrombi is important if thrombolytic therapy or surgical thrombectomy is considered. Clinical symptoms as well as duplex-ultrasound and phlebography are unreliable in this respect and do not allow an exact age estimation. Ultrasound elastography can provide information about the el... |
29,955 | Venous thromboembolism during pregnancy is not associated with persistent elevated activated protein C (APC) sensitivity ratio based on the endogenous thrombin potential. | Women who are using oral contraceptives can acquire APC resistance, measured by the effect of APC on the endogenous thrombin potential (ETP). The objective of our study was to examine whether persistentAPC resistance determined with an ETP-based normalized APC sensitivity ratio (nAPCsr) is a risk marker for venous thro... |
29,956 | Effect of ethnicity and gender on the incidence of venous thromboembolism in a diverse population in California in 1996. | There have been very few studies that have describe the epidemiology of first-time venous thromboembolism (VTE) in a large, ethnically diverse population. The California Discharge Data Set was used to identify a cohort of cases with incidentVTE in 1996. Cases associated with traditional provoking risk factors were iden... |
29,957 | Antiprothrombin antibodies detected in two different assay systems. Prevalence and clinical significance in systemic lupus erythematosus. | We evaluated the clinical significance of aPT and aPS-PT by testing for the presence of these antibodies in 212 SLE patients and in 100 healthy individuals. Results show that anti-prothrombin antibodies were found in 47% of the patients (aPT in 31% and aPS-PT in 31%). Their presence did not correlate with that of aCL, ... |
29,958 | Gender differences in the administration of prophylaxis to prevent deep venous thrombosis. | We investigated gender differences in the prescription of prophylaxis against deep vein thrombosis (DVT) in 2,619 patients who developed acute DVT while being hospitalized for reasons other than DVT or were diagnosed with acute DVT as outpatients but who had been hospitalized within 30 days prior to DVT diagnosis. Men ... |
29,959 | Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome. A systematic review and meta-analysis. | Perioperative antithrombotic clinical regimens have reduced the incidence of postoperative deep venous thrombosis (DVT). Long-term effects of asymptomatic postoperative DVT have been studied in a number of clinical trials and the present review describes the clinical significance of asymptomatic postoperative DVT regar... |
29,960 | Dramatic vascular course of Behcet's disease. | Vascular involvement in Behcet's disease is rare approximately 14% venous and 1.6% arterial, serious and recurrent. We report a case of Behcet's disease with deep venous thrombosis and right iliac pseudoaneurysm which was repaired with polytetrafluoroethylene PTFE graft. The patient received warfarin, aspirin, clopidog... |
29,961 | New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin. | The limitations of traditional anticoagulants, heparin and warfarin, have prompted the development of new anticoagulant drugs for prevention and treatment of both venous and arterial thromboembolism. After a brief review of thrombogenesis and its regulation, this paper focuses on new anticoagulant agents in more advanc... |
29,962 | Thrombotic complications and thromboprophylaxis in breast and gynaecological malignancies. | Thrombotic complications are a common cause of morbidity and mortality in patients with gynaecological or advanced breast malignancies. There are several manifestations of thromboembolism in these patients, but deep venous thrombosis of the legs is the usual presentation. This review highlights various manifestations o... |
29,963 | Prognostic factors for survival in patients with early-intermediate hepatocellular carcinoma undergoing non-surgical therapy: comparison of Okuda, CLIP, and BCLC staging systems in a single Italian centre. | Several prognostic models have been developed to stage hepatocellular carcinoma (HCC) but there is no general consensus on which is the most reliable. We compared three prognostic indices (Okuda, CLIP, and BCLC scoring systems) in a large series of cirrhotic patients with HCC undergoing non-surgical treatment in terms ... |
29,964 | An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization. | To evaluate an antisense oligodeoxynucleotide (AS-ODN) targeted against vascular endothelial growth factor for its effects on ocular angiogenesis and its intraocular localization in a nonhuman primate model of iris neovascularization.</AbstractText>Bilateral laser retinal vein occlusion was performed in monkeys, follow... |
29,965 | Efficacy and safety of fixed low-dose dalteparin in preventing venous thromboembolism among obese or elderly hospitalized patients: a subgroup analysis of the PREVENT trial. | We were concerned that a fixed rather than a weight-based dosing regimen of dalteparin sodium to prevent venous thromboembolism (VTE) might result in decreased efficacy in obese patients and decreased safety in elderly patients.</AbstractText>We retrospectively performed subgroup analyses using the database from the Pr... |
29,966 | Thrombosis as a conformational disease. | Conformational diseases are a newly recognized group of heterogeneous disorders resulting from the conformational instability of individual proteins. Such instability allows the formation of intermolecular linkages between b-sheets, to give protein aggregation and inclusion body formation. The serpin family of serine p... |
29,967 | [Brachial percutaneous venous access. Its usefulness in the diagnostic and interventionist catheterism of complex cardiopathies]. | Venous access through the superior caval vein is mandatory to study the pulmonary arteries in patients with a Glenn anastomosis. In complex congenital heart disease, repeat catheterizations may lead to iliac vein thrombosis and superior access is needed. In order to avoid the internal jugular venous puncture, we have u... |
29,968 | Thrombosis and thrombophilebitis of the internal jugular vein as a very rare complication of the ventriculoatrial shunt. | A 21-year-old man presented with a sausage shaped mass lesion, located in the right anterolateral region of the neck. He had been operated on for hydrocephalus and thoraco-lumbar myelomeningocele at the age of 10 days and 2 months, respectively. Although he was asymptomatic at the age of 10 years, ventriculoatrial (VA)... |
29,969 | Cerebral venous thrombosis: an all or nothing disease? Prognostic factors and long-term outcome. | There is insufficient data on short- and especially long-term prognosis of cerebral venous thrombosis (CVT).</AbstractText>In 79 consecutive patients, we analyzed factors for acute death and functional outcome at hospital discharge and after 6 months as well as long-term prognosis >/=12 months. Neurological deficits... |
29,970 | Are erythema nodosum-like lesions and superficial thrombophlebitis prodromal in terms of visceral involvement in Behcet's disease? | Erythema nodosum (EN)-like lesions and superficial thrombophlebitis (ST) are skin symptoms that are frequently observed in Behcet's disease. In most of the patients, skin symptoms precede serious visceral involvement. The study included 78 patients whose mean age was 33.48 +/- 6.16 (21-48). Of the cases, 37 were female... |
29,971 | Management options for thrombophilias. | Thrombophilias may be inherited or acquired, continuing or transient, and may contribute strongly or weakly to thrombosis. They may predispose to venous thromboembolism alone or also to artery occlusion. Advice on management must recognize these variations. The presence of an inherited thrombophilia should not alter th... |
29,972 | Thrombophilia in cancer. | Malignancy is an acquired thrombophilic condition associated with a significant risk of thrombosis. Venous and arterial thromboembolism is a common complication for patients with cancer, who also present with a hypercoagulable state, even in the absence of manifest thrombosis. Furthermore, clotting activation may play ... |
29,973 | Thrombophilia related issues in women and children. | Women experience increased thrombotic risk at pregnancy and puerperium as well as during hormonal therapy with oral contraceptives or hormone replacement therapy. Physiological and anatomical changes in pregnancy contribute to the hypercoagulable situation. Women with thrombophilia have an increased risk for venous and... |
29,974 | Travel, venous thromboembolism, and thrombophilia. | Current evidence indicates that prolonged air travel predisposes to venous thrombosis and pulmonary embolism. An effect is seen once travel duration exceeds 6 to 9 hours and becomes obvious in long-haul passengers traveling for 12 or more hours. A recent records linkage study found that increase in thrombosis rate amon... |
29,975 | Genetic testing for thrombophilia mutations. | Venous thrombosis is a multicausal disease due to the interaction of genetic and environmental risk factors. Some of the recently discovered genetic risk factors, such as factor V Leiden and prothrombin G20210A mutations, are quite common in the population. Accordingly, laboratory investigation of thrombophilic disorde... |
29,976 | Antiphospholipid syndrome: clinical and diagnostic utility of laboratory tests. | Antiphospholipid antibodies are a wide and heterogeneous group of immunoglobulins that include, among others, lupus anticoagulants and anticardiolipin antibodies. Their presence in patients with arterial and venous thrombosis, and/or obstetrical complications, defines the antiphospholipid syndrome. Antiphospholipid ant... |
29,977 | Laboratory detection of inherited thrombophilia: a historical perspective. | Considerable progress has been made in determining the molecular bases of inherited thrombophilia in the last 25 years. There are several genetic abnormalities that can be detected in the laboratory and are currently recognized to be unequivocally associated with an increased tendency to develop venous thrombosis. Test... |
29,978 | Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia. | Recommendations for transitioning from therapy with heparin or a low-molecular-weight heparin preparation to therapy with an oral anticoagulant in patients with acute venous or arterial thromboembolism have undergone several changes during the last two decades. Physicians are now comfortable with beginning treatment wi... |
29,979 | Cases of heparin-induced thrombocytopenia elucidate the syndrome. | Patients with heparin-induced thrombocytopenia (HIT) can have a dramatic presentation and often an unfortunate outcome. Each episode has the real potential to result in clinical catastrophe. From the > 100 such patients that we see yearly, patients have been selected to illustrate aspects of HIT such as history, epi... |
29,980 | The management of patients with heparin-induced thrombocytopenia who require anticoagulant therapy. | For patients with heparin-induced thrombocytopenia (HIT), reexposure to heparin is generally not recommended. However, these patients are likely to require anticoagulation therapy at some point in the future. During acute HIT, when thrombocytopenia and anti-heparin-platelet factor 4 antibodies (or HIT antibodies) are p... |
29,981 | Latex D-dimer signal in in situ femoral vein thrombus in swine and effect of minidose exogenous tissue plasminogen activator bolus. | We created in situ femoral vein thrombi in swine to investigate the response of the latex d-dimer signal to acute in situ venous thrombosis, and to determine the minimum dose of exogenous bolus tissue plasminogen activator (t-PA) required to significantly elevate the d-dimer signal.</AbstractText>We studied seven swine... |
29,982 | Invasive group A streptococcal infection in high school football players, New York City, 2003. | After being notified that 2 high school football teammates from New York City were hospitalized with confirmed or suspected invasive group A streptococcal infections, we conducted an investigation of possible spread among other team members. This investigation highlights a need for guidelines on management of streptoco... |
29,983 | A new anti-embolism stocking. Use of below-knee products and compliance. | This article highlights the need to use graduated compression stockings (GCS) in deep vein thrombosis (DVT) prophylaxis. A survey carried out at the Middlesex Hospital, part of the UCLH NHS Trust, London, ascertains the prevalence of patients wearing either above- or below-knee GCS and whether or not these were worn co... |
29,984 | Integrated approach to construction and maintenance of prosthetic arteriovenous access for hemodialysis. | Autogenous arteriovenous access is the preferred access for hemodialysis patients with end-stage renal disease but is not feasible in a significant number of patients. The creation of a prosthetic arteriovenous access (PAVA) for hemodialysis using expanded polytetrafluoroethylene is technically simple and the short-ter... |
29,985 | Early technical and clinical results with retrievable inferior vena caval filters. | Deep venous thrombosis with or without subsequent pulmonary embolism is a common preventable cause of hospital death. Although anticoagulation is the accepted standard therapy for thromboembolic disease, in situations in which anticoagulation is contraindicated, interruption of the inferior vena cava (IVC) by means of ... |
29,986 | Screening for proximal deep vein thrombosis after acute ischemic stroke: a prospective study using clinical factors and plasma D-dimers. | Deep vein thrombosis (DVT) remains common in patients with acute ischemic stroke (AIS) receiving aspirin and graded compression stockings (considered standard thromboprophylaxis in the UK), most events occurring in patients with Barthel indices (BI) of <9 ('severe stroke') around the time of admission. In the absenc... |
29,987 | Hyperhomocysteinemia, thrombosis and vascular biology. | Epidemiological evidence suggests that hyperhomocysteinemia (HH) is an independent risk factor for arterial thrombotic diseases such as acute myocardial infarction, stroke, peripheral ischemic occlusive disorders as well as venous thromboembolism. This article presents a hypothesis to explain the pathogenesis of increa... |
29,988 | The role of hyperhomocysteinemia in nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilatation. | Hyperhomocysteinemia (HHcy) is associated with impaired endothelial-dependent vasodilatation and increased risk of atherosclerosis and thrombosis. Here, we summarize some of our previous work on the effect of HHcy on pathways involved in endothelium-dependent vasodilatation, and present new data concerning the endothel... |
29,989 | [Pediatric cardiac pacing: indications, implant techniques, pacing mode]. | Over the last years, pacing leads design and pacemaker (PM) generator size, reliability, and longevity have markedly improved, so that reliable paediatric implant can now be performed at any age with a low complication rate. Main indications include congenital and postoperative atrioventricular block (AVB) and postoper... |
29,990 | [Preliminary studies on in vitro and in vivo thrombolytic activities of thrombolytic enzyme from an induced Bacillus subtilis strain]. | To separate and purify a novel thrombolytic enzyme (FSC2-13) from culture media of an induced Bacillus subtilis strain and to study its in vitro and in vivo thrombolytic activities.</AbstractText>Employed fibrin plate method, pyrogenation (heating up) fibrin plate method and SDS-PAGE were used respectively to study FSC... |
29,991 | Post gravidic superior sagittal sinus thrombosis with elevated levels of homocystinemia. | Cerebral ischemia in the young (less than 45 years) is an uncommon finding, its ethiology remaining undefined in up to half of cases even if all the common diagnostic paths have been followed. Pregnancy and puerperium are characterised by an increased risk of ischemic stroke and intracranial venous thrombosis. We prese... |
29,992 | Staphylococcus aureus relapsing bacteremia originating from endovascular thrombi. | Two infants presented with a recurrent methicillin-susceptible Staphylococcus aureus bacteremia occurring >2 months after the initial bacteremia. In both patients, clonal identity of the successive Staphylococcus aureus isolates, confirmed by pulsed field gel electrophoresis, pointed to relapsing bacteremia. Ultraso... |
29,993 | Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial. | Ximelagatran, an oral direct thrombin inhibitor with a rapid onset of action and predictable antithrombotic effect, has the potential to be a simple therapeutic alternative to current standard treatment of acute venous thromboembolism.</AbstractText>To compare the efficacy and safety of ximelagatran with standard enoxa... |
29,994 | Duodenal dearterialization and stapling for severe hemorrhage from duodenal varices with portal vein thrombosis. | Hemorrhage from duodenal varices is a rare but frequently fatal cause of gastrointestinal bleeding. Portal vein thrombosis may worsen the bleeding and prevent access for reduction of variceal pressure.</AbstractText>A technique to control bleeding and reduce inflow pressure to the varices is described. It includes liga... |
29,995 | Use of D-dimer to aid in excluding deep venous thrombosis in ambulatory patients. | Duplex imaging is currently the gold standard for diagnosing deep venous thrombosis (DVT), but its nonselective use overburdens vasuclar laboratories, particularly during off hours. It is the purpose of this study to determine if a new D-dimer assay could be used as an aid in determing whether duplex imaging could be p... |
29,996 | Prophylaxis and treatment of deep vein thrombosis in general surgery. | Patients undergoing general surgery present an inherent risk of deep vein thrombosis (DVT). Evidence-based strategies for prevention and treatment of DVT should be continuously upgraded on the basis of good-quality recent trials.</AbstractText>Articles were identified using MEDLINE, EMBASE, and the Cochrane Library dat... |
29,997 | [Graft viability of patients with renal transplantation from non heart beating donors]. | Renal transplantation (RT) is currently the treatment of choice in end-stage renal disease. The Gregorio Marañón hospital performed 65 RT, 97.01 pmp, this year.</AbstractText>To study the characteristics which RT patients from non-heart beating donors have in the immediate post-transplantation renogram. To kn... |
29,998 | Fondaparinux: an update on new study results. | Fondaparinux (Arixtra) is the first selective factor Xa inhibitor approved for use in thromboprophylaxis after orthopaedic surgery. New recently completed trials have also demonstrated the potential of fondaparinux in the prevention of venous thromboembolism (VTE) in other surgical and medical settings and in the treat... |
29,999 | Rationale for the use of antifactor Xa in the treatment and prevention of venous and arterial thromboembolic events. | The design and synthesis of new antithrombotic agents have led to numerous recent clinical trials to investigate their efficacy and safety. Analysis of the data from these trials, especially when the results were not totally expected, has provided interesting information, allowing a better understanding of the pathophy... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.