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30,600 | Combination treatment of venous thoracic outlet syndrome: open surgical decompression and intraoperative angioplasty. | Residual subclavian vein stenosis after thoracic outlet decompression in patients with venous thoracic outlet syndrome is often treated with postoperative percutaneous angioplasty (PTA). However, interval recurrent thrombosis before postoperative angioplasty is performed can be a vexing problem. Therefore we initiated ... |
30,601 | Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies. | Patients with antiphospholipid antibodies (APLAs) are at increased risk for arterial and venous thrombosis. Many APLAs associated with these events react with beta2 glycoprotein I (beta2GPI), and endothelial cell reactive antibodies that activate endothelial cells in a beta2GPI-dependent manner occur commonly in these ... |
30,602 | [Should adjuvant treatments (antiplatelet agents, anticoagulants, normovolaemic haemodilution and vasodilators) be used in cervicofacial and maxillofacial free flaps reconstructive surgery?]. | The ENT and maxillo-facial reconstruction with free flaps has become a standard. The objective of the adjuvant treatments is to limit failures (approximately 6%) related to ischaemia/reperfusion. French surgical centres use specific protocols depending on the surgeon. They used antiplatelet agent, anticoagulants, normo... |
30,603 | Safety of a new oral contraceptive containing drospirenone. | New chemical entities must undergo rigorous, and preferably independent, safety and efficacy assessments before entry into the market. This is also true for oral contraceptives (OCs) given their extensive usage by healthy women and the safety concerns highlighted by the so-called 'third generation pill scare' in Europe... |
30,604 | The incidence of deep vein thrombosis and pulmonary embolism after total knee arthroplasty: the screening study by radionuclide venography. | Deep vein thrombosis (DVT) and pulmonary embolism (PE) are considered uncommon in Asian populations and thrombo-prophylaxis is rarely indicated. The objective of this study was to investigate the incidence of DVT and PE after total knee replacement in an Asian population.</AbstractText>There were 100 patients who under... |
30,605 | A silent killer--often preventable. | Deep vein thrombosis and its potentially fatal complication, PE, accounts for more than 250,000 hospitalizations annually in the United States. Pulmonary embolism is the most serious complication and has a 3-month mortality of 17%. Two million people each year are affected by VTE, and the prevalence is rising because o... |
30,606 | [Clinical and instrumental surveillance of the arteriovenous fistula]. | Stenosis and thrombosis are the most important complications leading to vascular access failure in hemodialysis (HD). Aiming for an early access dysfunction diagnosis and elective repair of the failing access, the DOQI guidelines recommend that all HD patients undergo a program of regular monitoring and surveillance. T... |
30,607 | [Deep venous thrombosis: an early manifestation of Behçet's disease in childhood]. | Behcet's disease is a multisystemic vasculitis of unknown origin whose classical triad is oral and genital ulcers and uveitis. Deep venous thrombosis may sometimes be the first manifestation of this disease but is very rare in children. We report the case of a 14-year-old boy with deep venous thrombosis of the leg and ... |
30,608 | [Thromboprophylaxis in post-surgical patients: review of 1,500 cases]. | Deep venous thrombosis (DVT) and pulmonary embolism (PE) are entities with a relative high frequency in post-surgical patients and can occur immediately after the surgical procedure or even two or three weeks after the surgical event. In the United States and Europe, DVT is present in over 5 million events each year, w... |
30,609 | Readmissions for venous thromboembolism: expanding the definition of patient safety indicators. | The Agency for Healthcare Research and Quality (AHRQ) defines its venous thromboembolism (VTE) patient safety indicator (PSI) as surgical cases with a secondary diagnosis of pulmonary embolism or deep vein thrombosis. Short-term readmissions for VTE are excluded because most state administrative databases are unable to... |
30,610 | [Diagnostic image (204). A man with abdominal pain and fever]. | In a 53-year-old man with acute sigmoid diverticulitis abdominal CT revealed septic thrombophlebitis with gas configurations in the inferior mesenteric vein. |
30,611 | [Cerebral venous thrombosis associated to subacute De Quervain's thyroiditis in a carrier for the G20210A mutation of the prothrombin gene]. | Recently, thyrotoxicosis has been described as a risk factor for cerebral venous thrombosis (CVT) in some reported cases. We present a case of CVT associated to a subacute De Quervain's thyroiditis in a young female who was an heterozygous carrier for the G20210A mutation of the prothrombin gene.</AbstractText>A 42-yea... |
30,612 | Low molecular weight heparin (tinzaparin) therapy for moderate risk thromboprophylaxis during pregnancy. A pharmacokinetic study. | Low molecular weight heparin (LMWH) is used increasingly for prophylaxis and treatment of venous thromboembolism during pregnancy. However, the prophylactic dose for patients at moderate risk varies between centers, and the recommended LMWH dose for the non pregnant patient is frequently used in pregnant women. The aim... |
30,613 | A case series of 72 neonates with renal vein thrombosis. Data from the 1-800-NO-CLOTS Registry. | Neonatal renal vein thrombosis (RVT) is a well-recognized clinical entity which is associated with serious morbidity. However, current information regarding RVT has been restricted to case reports and small case series. In this study, it was our objective to describe patient demographics, clinical presentation, locatio... |
30,614 | Systemic thromboembolism in children. Data from the 1-800-NO-CLOTS Consultation Service. | Thromboembolism (TE) has recently been recognized as a clinical entity in children. Determining the clinical characteristics of pediatric TE is an important first step in dealing with this new disorder. The paper summarizes 1776 consecutive children with systemic TE referred to 1-800-NO-CLOTS telephone consultation ser... |
30,615 | Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study. | The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003,... |
30,616 | Total tissue factor pathway inhibitor is an independent risk factor for symptomatic paediatric venous thromboembolism and stroke. | Tissue factor pathway inhibitor (TFPI) plays an important role in inhibiting tissue factor-induced coagulation by a factor Xadependent pathway of the activated tissue-factor VIIa complex. Decreased values of the latter inhibitor have been recently reported in adult patients with venous thrombosis (VT) or ischaemic stro... |
30,617 | A prospective trial that demonstrates that dalteparin requirements increase in pregnancy to maintain therapeutic levels of anticoagulation. | The purpose of this study was to determine whether standard therapeutic doses of dalteparin maintain peak therapeutic levels of anticoagulation during pregnancy.</AbstractText>This was a prospective trial in which 13 pregnancies that required therapeutic anticoagulation were treated with dalteparin 100 U/kg every 12 ho... |
30,618 | Estimates of risk of venous thrombosis during pregnancy and puerperium are not influenced by diagnostic suspicion and referral basis. | The purpose of this study was to determine the relative risk of deep vein thrombosis (DVT) during pregnancy and puerperium in a setting that was not influenced by diagnostic suspicion and referral bias.</AbstractText>Three hundred ninety-three consecutive females with suspicion of a first episode of venous thrombosis w... |
30,619 | Current topics on vascular access for hemodialysis. | Vascular access remains the lifeline for end-stage renal failure patients, which have been treated by chronic intermittent hemodialysis. Due to the steady increase in the number of patients with difficulties to create access, in particular in elderly with various comorbidities, the need for more insight and regulations... |
30,620 | Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis. | Clinical trial evidence indicates that estrogen therapy with or without progestins increases venous thrombotic risk. The findings from these trials, which used oral conjugated equine estrogens, may not be generalizable to other estrogen compounds.</AbstractText>To compare risk of venous thrombosis among esterified estr... |
30,621 | Reduced plasma fibrinolytic potential is a risk factor for venous thrombosis. | The role of the fibrinolytic system in the development of deep vein thrombosis (DVT) is unclear. We determined the plasma fibrinolytic potential of patients enrolled in the Leiden Thrombophilia Study (LETS), a population-based case-control study on risk factors for DVT. Plasma fibrinolytic potential was determined in 4... |
30,622 | Aggressive multimodal treatment for peritoneal dissemination and needle tract implantation of hepatocellular carcinoma: a case report. | We encountered a patient with hepatocellular carcinoma (HCC) with peritoneal dissemination and needle tract implantation, both of which were strongly suspected to have been caused by percutaneous needle biopsy. The patient was a 65-year-old man. Partial hepatectomy of subsegment VI had been performed following the diag... |
30,623 | Three-dimensional conformal radiation therapy for unresectable hepatocellular carcinoma patients who had failed with or were unsuited for transcatheter arterial chemoembolization. | The purpose of our study was to evaluate the outcome of unresectable hepatocellular carcinoma (HCC) patients, who had either failed with or were unsuited for transcatheter arterial chemoembolization (TACE), treated with three-dimensional conformal radiation therapy (3DCRT) and to determine the prognostic outcome factor... |
30,624 | Thrombosis of the internal cerebral vein associated with transient unilateral thalamic edema: a case report and review of the literature. | Thrombosis of the deep venous system presenting with bilateral thalamic infarction or edema is a common finding, but unilateral venous thrombosis presenting with unilateral thalamic edema is extremely rare. We report a case of a patient with this unusual condition presenting with nonspecific clinical signs and symptoms... |
30,625 | The sudden infant death syndrome gene: does it exist? | Sudden infant death syndrome (SIDS) is in a difficult position between the legal and medical systems. In the United Kingdom, prosecutors have for years applied the simple rule that 1 unexpected death in a family is a tragedy, 2 are suspicious, and 3 are murder. However, it seems that the pendulum has now swung to the o... |
30,626 | Adverse effects of thalidomide administration in patients with neoplastic diseases. | Thalidomide, a glutamic acid derivative, was withdrawn from clinical use in 1962 due to its severe teratogenic effects. Its recent reinstitution in clinical practice was related to its benefits in leprosy and multiple myeloma. Moreover, the antiangiogenic and immunomodulatory properties of thalidomide have led to its e... |
30,627 | [Superior sagittal sinus occlusion caused by a compound depressed skull fracture: a case treated by emergency surgery]. | Depressed skull fractures compressing major venous sinuses are rare, and the treatment is a matter of controversy. The majority of depressed fractures are treated conservatively for fear of bleeding from venous sinuses, but surgical intervention was conducted in a few cases. We report a case of a 59-year-old man with a... |
30,628 | Factor V Leiden: association with venous thromboembolism in pregnancy and screening issues. | Disturbances of the natural balance between procoagulant and anticoagulant mechanisms can result in bleeding or thrombotic tendencies. Factor V, on activation by thrombin to factor Va, forms an essential component of the prothrombinase complex, in which it demonstrates its cofactor activity for factor Xa. Down-regulati... |
30,629 | The effects of folic acid supplements on coagulation status in pregnancy. | Thromboembolic disease remains the leading cause of maternal death in the UK. Recent literature has proposed that folate status is a strong predictor for venous thrombosis. Using thrombelastography (TEG((R))), we tested the hypothesis that folic acid supplementation is associated with a reduction in whole blood coagula... |
30,630 | Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. | Protein Z-dependent protease inhibitor (ZPI) is a serpin that inhibits the activated coagulation factors X and XI. The precise physiological significance of ZPI in the control of haemostasis is unknown although a deficiency of ZPI may be predicted to alter this balance. The coding region of the ZPI gene was screened fo... |
30,631 | Treatment of acute fractures of the femoral shaft with reamed intramedullary interlocking AO nails. | To review and audit our experience with closed intramedullary interlocking nailing for acute femoral shaft fractures.</AbstractText>All patients admitted to The Aga Khan University Hospital, over the last six years and with a minimum follow-up of twelve months, with acute fractures of the femoral shaft were included in... |
30,632 | Thrombophilia screening: a matter of debate. | In the last ten years, several risk factors that increase the risk of venous thrombosis have been discovered. Venous thrombosis is a multicausal disease in which several risk factors, both genetic and acquired, have to occur simultaneously to cause thrombosis. This means that most individuals with single thrombophilia ... |
30,633 | Impaired warfarin response secondary to high-dose vitamin K1 for rapid anticoagulation reversal: case series and literature review. | The literature suggests that unresponsiveness to warfarin can continue for 1 week or longer after administration of high-dose vitamin K1 10 mg or greater; however, there is a lack of supporting data to define the duration and clinical consequences of impaired warfarin response with high doses of vitamin K1. This case s... |
30,634 | Inhibition of endogenous leptin protects mice from arterial and venous thrombosis. | Human obesity is associated with an increased risk for arterial and venous thrombosis and with elevated levels of leptin in the blood. Leptin administration promotes arterial thrombosis in mice, and leptin-deficient ob/ob mice have an attenuated thrombotic response to injury. Thus, endogenous leptin may regulate arteri... |
30,635 | Safety and adverse effects associated with raloxifene: multiple outcomes of raloxifene evaluation. | To examine the effect of raloxifene on major adverse events that occur with postmenopausal estrogen therapy or tamoxifen.</AbstractText>The Multiple Outcomes of Raloxifene Evaluation, a multicenter, randomized, double-blind trial, enrolled 7,705 postmenopausal women with osteoporosis. Women were randomly assigned to ra... |
30,636 | Unusual cause of deep vein thrombosis following dynamic hip screw fixation. | We report a case of profunda femoris false aneurysm following internal fixation of an intertrochanteric neck of femur fracture, caused by proximal migration of a fracture fragment. The case is unique in that the mode of presentation was that of deep venous thrombosis, due to extrinsic compression of the venous system b... |
30,637 | Ileus following total hip or knee arthroplasty is associated with increased risk of deep venous thrombosis and pulmonary embolism. | Venous thromboembolic disease (VTD), deep venous thrombosis and pulmonary embolism, causes morbidity and mortality following total hip and total knee arthroplasties, while ileus complicates up to 4.0%. The clinical courses of 2,949 patients undergoing 3,364 consecutive primary and revision total hip and total knee arth... |
30,638 | Efficacy of fondaparinux for thromboprophylaxis in hip fracture patients. | Fondaparinux efficacy for thromboprophylaxis was evaluated in predefined high-risk hip fracture patients. Patients received fondaparinux 2.5 mg for 7 days following surgery; 656 patients were randomized double blind to receive placebo or continue fondaparinux regimen for 21 additional days. Primary efficacy was venous ... |
30,639 | Venous thromboembolism prophylaxis after head and spinal trauma: intermittent pneumatic compression devices versus low molecular weight heparin. | Although there are alternative methods and drugs for preventing venous thromboembolism (VTE), it is not clear which modality is most suitable and efficacious for patients with severe (stable or unstable) head/spinal injures. The aim of this study was to compare intermittent pneumatic compression devices (IPC) with low-... |
30,640 | Surgical and endovascular procedures for treating isolated iliac artery aneurysms: ten-year experience. | Characteristics of atherosclerotic isolated iliac artery aneurysms (IAAs) and various strategies for their treatment were assessed retrospectively. The computerized medical records of 18 patients who underwent surgical or endovascular treatment of an IAA during the 10 years from April 1993 to March 2003 at our universi... |
30,641 | A randomized trial of patient self-managed versus physician-managed oral anticoagulation. | Self-management (SM) of warfarin by patients is an attractive strategy, particularly if it improves anticoagulation control and can be done safely under minimal physician supervision.</AbstractText>To compare the effect of SM with physician-management (PM) on the maintenance of therapeutic anticoagulation.</AbstractTex... |
30,642 | [Acute lung embolism: a prospective study from May 1992, to May 2002]. | To define de prevalence, the clinical profile, the predisposing factors and the hospital evolution of clinical acute lung thromboembolism episodes.</AbstractText>A prospective study from May 1992, to May 2002, of acute lung embolism in an Internal Medicine ward with 8 beds in Hospital of Navarra (EPHONA). Clinical acut... |
30,643 | Personalized versus non-personalized computerized decision support system to increase therapeutic quality control of oral anticoagulant therapy: an alternating time series analysis. | The quality control of oral anticoagulant therapy (OAT) during the initiation and maintenance treatment is generally poor. Physicians' ordering of OAT (especially fluindione and warfarin) can be improved by dose adjustment algorithms, taking into account the results of International Normalized Ratio (INR). Reminders at... |
30,644 | The risk of a venous thrombotic event in lung cancer patients: higher risk for adenocarcinoma than squamous cell carcinoma. | Only limited data on the incidence of venous thrombosis in different types of malignancy are available. Patients with adenocarcinoma are believed to have the highest risk of developing venous thrombosis.</AbstractText>To study the incidence of thrombosis in patients with lung cancer, with an emphasis on the comparison ... |
30,645 | Bilateral vs. ipsilateral venography as the primary efficacy outcome measure in thromboprophylaxis clinical trials: a systematic review. | Contrast venography, in combination with symptomatic venous thromboembolism (VTE), is the standard efficacy outcome measure in clinical trials of thromboprophylaxis in major orthopedic surgery. It is uncertain whether performing bilateral venography offers any real advantage over venography of the operated leg alone. T... |
30,646 | Is bilateral duplex scanning necessary in patients with symptoms of deep venous thrombosis? | Venous duplex ultrasound scanning (VDUS) has been shown to be an accurate non-invasive means to diagnose symptomatic deep venous thrombosis (DVT). The aim of our study was to determine whether bilateral VDUS is necessary in patients who present with symptoms of DVT.</AbstractText>We retrospectively reviewed the results... |
30,647 | [Complications and risks associated with an anticoagulation therapy combining low molecular weight heparin and Warfarin after total replacement of large joints--our experience]. | This study deals with the efficacy and safety of anticoagulation therapy, using a combination of low molecular weight heparin (LMWH) and Warfarin, administered after total arthroplasty (TA) of large joints. Patients with a high rate of complications due to bleeding comprised the first evaluated group. After the causes ... |
30,648 | [Deep venous thrombosis of the lower extremity. Ultrasonography should replace phlebography as first line diagnostic imaging]. | In Sweden, there is a widespread use of ascending venography for the diagnosis of deep vein thrombosis of the lower extremities (LEDVT) instead of ultrasonography. The main reason for this is the inferiority of US in diagnosing LEDVT in the calf veins. In order to indirectly estimate the magnitude of this inadequacy, w... |
30,649 | [Utility of intra-access pressure]. | Monitoring of vascular access is essential for clinical evaluation on hemodialysis patients, detects early disfunction of access, allows adequate dialysis and decreases the morbidity associated. Although is demonstrated that intra-access pressure (IAP) is a good method of screening to evaluate arterial-venous (AV) fist... |
30,650 | Local hyperthermia enhances thrombosis in aneurysms containing platinum coils. | Despite recent technical advances in embolization of cerebral aneurysms with platinum coils, some aneurysms eventually resulted in incomplete packing with remnant neck or dome filling. Such a situation with a remaining inflow zone may pose a risk of rupture and subsequent regrowth. Metals characteristically generate he... |
30,651 | Advances in DVT prophylaxis and management in major orthopaedic surgery. | Every year, approximately 2 million people experience a deep venous thrombosis (DVT). Approximately 600,000 of these people are diagnosed with a pulmonary embolism and about 10% of these die. It has been established that surgery, anesthesia, and bed rest increase the risk of DVT, and therefore, patients who undergo a m... |
30,652 | Radiolabeled peptides: overcoming the challenges of post-surgical patient management of venous thromboembolism. | The serious clinical and economic impact of venous thromboembolic (VTE) disease is undisputed. What concerns practitioners and researchers alike is the seeming inability to truly mitigate the ramification of VTE, especially in the post-surgical or postoperative subpopulation, in whom the risk of VTE is disproportionate... |
30,653 | Risk factors for catheter-related thrombosis in cancer patients. | We investigated the risk factors for venous thrombosis in cancer patients with implantable ports undergoing chemotherapy. One hundred and seventy one ports were placed in a central ("chest ports") and 84 in a peripheral vein ("arm ports"), 181 received prophylactic nadroparin and 10 coumarin. Clinically overt thrombosi... |
30,654 | Unilateral diabetic macular oedema secondary to central retinal vein congestion. | To describe two cases of strictly unilateral diabetic retinopathy with macular edema where the precipitating factor appears to have been retinal venous congestion.</AbstractText>Retrospective interventional case study.</AbstractText>Examination of fundus photographic records demonstrated generalized venous dilation in ... |
30,655 | Factor XIII V34L polymorphism modulates the risk of chronic venous leg ulcer progression and extension. | Low Factor XIII (FXIII) activity has been reported in the blood of patients with chronic venous leg ulcer (CVU). In vivo studies have described increased wound healing in CVU patients treated with FXIII concentrate, and in vitro studies have shown increased regenerative capacity in FXIII-treated fibroblasts. In additio... |
30,656 | Experimental retinal vein occlusion: effect of acetazolamide and carbogen (95% O2/5% CO2) on preretinal PO2. | To evaluate the variations of preretinal oxygen partial pressure (Po(2)) in normal and in ischemic postexperimental branch retinal vein occlusion (BRVO) areas, during normoxia, hyperoxia (100% O(2)), and carbogen (95% O(2), 5% CO(2)) breathing before and after intravenous injection of acetazolamide.</AbstractText>Prere... |
30,657 | Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study. | The prothrombin 20210A mutation has been associated with an increased risk of venous thromboembolism (VTE). Its relationship with arterial disease and pregnancy-related complications is, however, still uncertain. The aim of this study was to estimate the incidences of first venous and arterial thrombotic events and pre... |
30,658 | Outcomes of extended oral contraceptive regimens with a shortened hormone-free interval to manage breakthrough bleeding. | To evaluate in a clinical practice setting the acceptance, continuation and variability of extending the active interval of oral contraceptives (OCs) with introduction of a shortened hormone-free interval (HFI) to manage breakthrough bleeding.</AbstractText>A retrospective review was undertaken of patients seen by one ... |
30,659 | Intravenous immunoglobulin in secondary progressive multiple sclerosis: randomised placebo-controlled trial. | Several double-blind placebo-controlled trials of relapsing-remitting multiple sclerosis have shown beneficial effects of intravenous immunoglobulin (IVIG) on relapse rate and disability. The European Study on Intravenous Immunoglobulin in Multiple Sclerosis set out to test IVIG in the secondary progressive phase of th... |
30,660 | Diagnosis of deep venous thrombosis and alternative diseases in symptomatic outpatients. | BACKGROUND: The management of patients with suspected deep vein thrombosis (DVT) is controversial. Recent studies have suggested that anticoagulant treatment can safely be withheld if the clinical probability is low and the D-dimer concentration in blood is normal. We examined a diagnostic algorithm comparing a score-b... |
30,661 | Current status of pulmonary embolism in general surgery in Japan. | The true incidence of pulmonary embolism (PE) after general surgery in Japan is unknown. We searched the PubMed and Japana Centra Revuo Medicina 1985-2002 databases, entering "surgery" and "pulmonary embolism" or "thromboembolism", and reviewed the reported incidence of clinical PE associated with general surgery in Ja... |
30,662 | Simple screening method for deep vein thrombosis by duplex ultrasonography using patients' active maximum ankle dorsiflexion. | We hypothesized that venous obstruction by deep vein thrombosis (DVT) only slightly augments venous outflow from lower limbs by active ankle movements. If our hypothesis is true, we thought that we could develop a new screening method for DVT using duplex ultrasonography. Subjects were 22 lower limbs of 11 patients who... |
30,663 | Protein C system defects in Indian children with thrombosis. | As ethnic variations are known to exist in inherited genetic defects, the clinico-haematological profile of Indian children with thrombophilia may be different from that of Caucasians. The aim of the study was to analyse the phenotypic and genotypic causes of thrombophilia in Indian children. Forty patients with arteri... |
30,664 | Central retinal vein prethrombosis as an initial manifestation of protein S deficiency. | Retinal vein thrombosis is most common in old people, and is often associated with systemic vascular disease. One of its rare systemic causes is protein S deficiency.</AbstractText>A case of a 21-year-old woman with retinal vein prethrombosis associated only with protein S deficiency is described. She presented with ac... |
30,665 | Treating heparin-induced thrombocytopenia. The unconventional way! | Heparin-induced thrombocytopenia HIT is a potentially devastating complication of heparin therapy. The severe form of HIT has been associated with both venous and arterial thrombosis manifested by myocardial infarction, cerebrovascular occlusion, skin necrosis or limb ischemia. Several agents are now available as alter... |
30,666 | Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) plasma levels in inflammatory bowel diseases. | Hypofibrinolysis has been proposed as a possible mechanism underlying the known risk of thrombosis observed in patients with inflammatory bowel diseases (IBD). Thrombin-activatable fibrinolysis inhibitor (TAFI) is a recently described inhibitor of fibrinolysis. Increased TAFI plasma levels are associated with a risk fo... |
30,667 | Economic evaluation of enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients. | To conduct an economic evaluation of the prevention of venous thromboembolism in acutely ill medical patients.</AbstractText>We used a previously described economic model created in the context of the UK National Health Service and applied it to St. Thomas' Hospital, London. A clinical review to determine the number of... |
30,668 | [Surgical treatment for bone and soft tissue sarcoma]. | There are many kinds of wide excision or wide resection, which are methods to remove the tumor with surrounding tissues. The curability of wide resection depends on the range and characteristics of the normal surrounding tissues. The fascia, periosteum and perivascular sheath act as barriers against invasion of tumors.... |
30,669 | Single-center study of technical graft loss in 714 consecutive renal transplants.<Pagination><StartPage>623</StartPage><EndPage>626</EndPage><MedlinePgn>623-6</MedlinePgn></Pagination><Abstract><AbstractText>No series has specifically focused on rates of technical failure in the kidney transplantation operation. We ret... | No series has specifically focused on rates of technical failure in the kidney transplantation operation. We retrospectively examined the incidence of technical graft loss in a single kidney transplant program. A total of 714 transplants were performed, with a mean follow-up of 3.4 years (range 2-5 years). Technical gr... |
30,670 | Percutaneous closure of patent foramen ovale guided by intracardiac echocardiography and performed through the transfemoral approach in the presence of previously placed inferior vena cava filters: a case series. | We present three patients with cryptogenic stroke who underwent transcatheter closure of a patent foramen ovale. All patients have had history of deep venous thrombosis and pulmonary embolism with placement of inferior vena caval filters. The patients were not initially considered suitable candidates for the procedure ... |
30,671 | Risk of venous thromboembolism in pediatric patients with brain tumors. | Venous thromboembolism (VTE) is a common event in adults with malignant brain tumors approaching 24% throughout the course of the disease. The high morbidity and mortality of this complication yielded several protocols for prevention of the disease in adults undergoing neurosurgery for brain tumors and possible primary... |
30,672 | Hyperhomocysteinemia and deep vein thrombosis in orthotopic heart transplantation: a case report. | Homocysteine has been recognized as a risk factor for atherosclerosis and arterial and venous thrombosis. Heart transplant patients have an increased prevalence of hyperhomocysteinemia. High homocysteine levels in transplant patients may promote development of cardiac allograft vasculopathy, but there is minimal inform... |
30,673 | [Central retinal vein occlusion in a factor V leiden and G21210A prothrombin variant carrier]. | A fifty-five year old man complained of diminished visual acuity in his right eye and reported a deep venous thrombosis in his right leg five years ago. Examination showed a central retinal vein occlusion in the right eye. Mutations in the factor V gene and prothrombin gene were found in a thrombophilia study. The pati... |
30,674 | Anti-thrombomodulin antibodies and venous thrombosis. | Thrombomodulin (TM) is a cell surface endothelial glycoprotein having anticoagulant properties. It inhibits thrombin, and activates protein C, leading to the inhibition of activated factors V and VIII. TM autoantibodies could theoretically predispose to thrombosis. We have tested 83 unselected patients with deep venous... |
30,675 | Cost analysis of fondaparinux versus enoxaparin as venous thromboembolism prophylaxis in elective hip replacement surgery. | Patients undergoing hip arthroplasty are at high risk for developing venous thromboembolic events (VTE) postoperatively in the absence of prophylaxis. In this study, a cost analysis comparing efficacy and safety data from a published trial evaluating fondaparinux and enoxaparin as VTE prophylaxis in hip replacement pat... |
30,676 | Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance. | Aspirin and the thienopyridines ticlopidine and clopidogrel are antiplatelet agents that display good antithrombotic activity. In the past few years, the concept of aspirin resistance has been largely emphasized in the medical literature, although its definition is still uncertain. I suggest that "aspirin-resistant" sh... |
30,677 | Combining clinical risk with D-dimer testing to rule out deep vein thrombosis. | We sought to determine whether the combination of low-intermediate clinical risk of acute lower extremity deep vein thrombosis (DVT) and negative ELISA D-dimer assay can eliminate the need for duplex ultrasonography. Three hundred thirty-six patients prospectively underwent clinical risk stratification (low, intermedia... |
30,678 | Pulmonary embolism and pregnancy. | Pulmonary embolism is a significant cause of morbidity and mortality during pregnancy and the puerperium. The spectrum of venous thromboembolism is difficult to diagnose. Objective diagnostic testing is crucial and should not be delayed. Anticoagulation is the mainstay of therapy for deep vein thrombosis and pulmonary ... |
30,679 | [Spontaneous resolution of extensive superior mesenteric and portal vein thrombosis. A case report]. | We present a case of subacute extensive thrombosis of the superior mesenteric vein, the venous branches of the jejunal vein, the portal vein at the hilum and its intrahepatic branches, with complete recanalization of the blood flow in the affected vessels without thrombolytic treatment. We provide a detailed descriptio... |
30,680 | [Clinical analysis of 61 patients with antiphospholipid syndrome]. | To investigate the clinical manifestations, diagnosis and treatment of anti-phospholipid syndrome (APS).</AbstractText>61 patients with defined APS admitted from Jan 1986 to Dec 2002 were analyzed retrospectively.</AbstractText>10 patients with primary APS and 51 patients with secondary APS were analyzed. Women were af... |
30,681 | Use of inferior vena caval filters and survival in patients with malignancy. | Inferior vena cava (IVC) filters have proven to be a viable alternative to anticoagulation therapy for the prevention of life-threatening pulmonary emboli (PE) for patients who have contraindications to anticoagulation therapy. The clinical benefit of placing IVC filters in patients with advanced-stage cancer is contro... |
30,682 | Incidence of deep vein thrombosis after varicose vein surgery. | Varicose vein surgery is generally considered to have little risk of postoperative deep vein thrombosis (DVT). This prospective study examined the incidence of DVT in patients undergoing varicose vein surgery.</AbstractText>Lower leg veins were assessed before operation by duplex ultrasonography in 377 patients, and re... |
30,683 | Fatal acute pulmonary embolism in a patient with pelvic lipomatosis after surgery performed after transatlantic airplane travel. | We describe a case of a 37-yr-old patient who traveled from Europe to the United States and succumbed to a massive pulmonary embolism 6 days after elective pelvic surgery despite routine postoperative thrombotic prophylaxis. In retrospect, he was likely to have developed a deep venous thrombosis during the transatlanti... |
30,684 | Patterns of referral for inferior vena caval filtration: delays and their impact. | We sought to study the referral patterns for inferior vena caval filtration and explore the relationship between delays in filter insertion and clinical outcomes.</AbstractText>We retrospectively reviewed 101 consecutive inferior vena caval filters inserted in 101 patients in a university hospital between the June 2000... |
30,685 | Branch retinal arterial occlusion associated with toxoplasmic chorioretinitis. | Ocular toxoplasmosis can cause a variety of retinal vascular changes including branch retinal arterial occlusion, which is a rare complication of the disease.</AbstractText>We report a case of toxoplasmic chorioretinitis in a pregnant woman, who developed branch retinal arterial obstruction adjacent to the active chori... |
30,686 | The impact of aborted radical hysterectomy in patients with cervical carcinoma. | To determine the impact of an aborted radical hysterectomy on morbidity and overall survival in patients undergoing surgical treatment for early stage cervical carcinoma.</AbstractText>Following IRB approval, a computerized database identified 304 women treated with radical surgery for early stage cervical carcinoma fr... |
30,687 | Recombinant human erythropoietin as an adjunct to radiation therapy and cisplatin for stage IIB-IVA carcinoma of the cervix: a Southwest Oncology Group study. | The survival of cervix cancer patients is associated with their hemoglobin (Hgb) level during radiotherapy. The Southwest Oncology Group (SWOG) conducted a phase II trial to determine whether recombinant human erythropoietin (rHuEPO) safely corrects anemia during chemoradiotherapy for cervix cancer.</AbstractText>Patie... |
30,688 | [A retrospective survey on practice of oral anticoagulant therapy in patients with cardiovascular diseases]. | Recently there are several evidence based facts about the beneficial effect of oral anticoagulant therapy in patients with cardiovascular diseases. In the other hand the often serious bleeding complications as well as the ineffective antithrombotic therapy should be avoided.</AbstractText>Authors had examined with a qu... |
30,689 | Transjugular intrahepatic portosystemic shunt (TIPS) in the treatment of venous symptomatic chronic portal thrombosis in non-cirrhotic patients. | To present a series of cases of non-cirrhotic patients with symptomatic massive portal thrombosis treated by percutaneous techniques. All patients underwent a TIPS procedure in order to maintain the patency of the portal vein by facilitating the outflow.</AbstractText>A total of six patients were treated for thrombosis... |
30,690 | Ximelagatran: an oral direct thrombin inhibitor. | To present the chemistry, pharmacology, and pharmacokinetics of ximelagatran, an oral direct thrombin inhibitor (DTI), and to review available comparative clinical trial data evaluating its efficacy and safety relative to other antithrombotic agents in the prevention and treatment of thromboembolism.</AbstractText>A se... |
30,691 | Antithrombotic therapy in children: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This article about antithrombotic therapy in children is part of the 7th American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh the risks, burden, and costs. Grade 2 ... |
30,692 | Use of antithrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This chapter about the use of antithrombotic agents during pregnancy is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that ind... |
30,693 | Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This chapter about treatment and prevention of stroke is part of the 7th ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that individual patients' v... |
30,694 | Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This chapter about antithrombotic therapy for venous thromboembolic disease is part of the seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests t... |
30,695 | Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This article discusses the prevention of venous thromboembolism (VTE) and is part of the Seventh American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden,... |
30,696 | Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, a... |
30,697 | New anticoagulant drugs: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This article about new anticoagulant drugs is part of the seventh American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. The limitations of existing oral and parenteral anticoagulant agents have prompted a search for novel agents. Focusing on new anticoagu... |
30,698 | Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. | This article about unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) is part of the Seventh American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. UFH is a heterogeneous mixture of glycosaminoglycans that bind to antithrombin via a penta... |
30,699 | Combined use of rapid D-dimer testing and estimation of clinical probability in the diagnosis of deep vein thrombosis: systematic review. | To summarise the evidence supporting the use of rapid d-dimer testing combined with estimation of clinical probability to exclude the diagnosis of deep venous thrombosis among outpatients.</AbstractText>Medline (June 1993 to December 2003), the Database of Abstracts and Reviews (DARE), and reference lists of studies in... |
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