Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,345,029	effect analysi virtual simul experiment platform teach pulpotomi experiment teach pediatr dentistri bridg theoret studi clinic practic virtual simul technolog provid new method instruct	D011672;D007858	T061;T062;T041
36,345,028	acceler amyloid angiopathi relat vascular alter mix murin model alzheim diseas type two diabet age main risk factor alzheim diseas ad emerg evid suggest metabol alter type diabet td also major contributor inde sever studi describ close relationship ad td clinic evid show diseas coexist hallmark patholog event ad amyloid deposit brain either amyloid plaqu around leptomening cortic arteriol thus constitut cerebr amyloid angiopathi caa caa observ autopsi case ad contribut ad patholog limit perivascular drainag	D000544;D003924;D011236;D016657	T047;T048
36,345,027	fungal esophag associ tubercul pericard human immunodefici virus posit patient case report opportunist infect frequent peopl live human immunodefici virus either access antiretrovir therapi art use irregular tuberculosi frequent infecti diseas plhiv predispos patient sever fungal infect dire consequ	D010495;D002177;D009181;D004941	T047
36,345,026	gonadotropin releas hormon agonist preserv ovarian function survivor haematopoiet stem cell transplant haematolog diseas administr gnrh agonist gnrha prior chemotherapi may decreas risk gonad dysfunct patient tumor howev relev data haematopoiet stem cell transplant hsct recipi yet establish henc present studi design evalu clinic efficaci gnrha cotreat prior myeloabl regimen ovarian protect femal survivor hsct haematolog diseas	D016649;D008594;D006402;D018380	T061;T047
36,345,025	hand surgeri hand therapi clinic practic guidelin epidermolysi bullosa alreadi known topic epidermolysi bullosa eb caus blister scar hand result contractur fuse web space alter function surgeri need releas contractur web space hand therapi essenti maintain result approach differ studi add guidelin aim provid inform surgic conserv therapeut hand manag children adult diagnos eb base avail evid expert consensus assist hand surgeon therapist decis make plan treatment highlight import holist multidisciplinari team mdt approach patient prioriti paramount	D004820;D003286;D016108	T019;T047;T190
36,345,023	influenc covid year carbon footprint nagoya univers hospit medic research centr amidst climat crisi key goal medic sector reduc larg carbon footprint although coronavirus diseas covid pandem great impact medic sector influenc carbon footprint remain unknown therefor aim studi evalu chang carbon footprint univers hospit medic research centr past year	D000086382;D035843	T062;T047;T067
36,345,021	impact set new medic school narrat review growth uk popul togeth age societi increas complex health social care need place greater demand statutori care servic view emerg landscap uk govern sought increas medic train workforc order better respond demand place health servic five univers announc home new medic school offer undergradu place boost number doctor train england aim narrat review explor new medic school could improv health outcom local popul evalu potenti contribut may make local economi workforc research innov	D012577;D019035	T058;T073;T093
36,345,020	addit extracorpor shock wave therapi improv effect isol percutan radiofrequ coblat patient insert achill tendinopathi studi protocol random control clinic trial conclus evid recommend prior treatment insert achill tendinopathi iat theoriz percutan radiofrequ coblat extracorpor shockwav therapi eswt reliev pain within insert howev clinic evid show either treatment promot regener tendon combin intervent offer better function less pain one therapi	D000074059;D000125;D052256;D019220	T061;T023;T070;T047
36,345,019	disrupt us local public health role popul base substanc use prevent respons covid covid dramat limit scale scope local health depart lhd work redirect resourc respons howev need essenti public health servic includ substanc use prevent reduc	D000086382;D019966	T033;T047;T067;T048
36,345,018	reimplant approach anomal aortic origin right coronari arteri aberr right subclavian arteri anomal aortic origin right coronari arteri rare diseas although various report treatment method surgic approach still controversi present rare case year old man anomal aortic origin right coronari arteri aberr right subclavian arteri treatment underw reimplant right coronari arteri surgic approach anomal aortic origin right coronari arteri select consid age patient size right coronari arteri	D018376;D003330	T019
36,345,017	endoplasm reticulum stress target therapi breast cancer recurr metastasi drug resist still big challeng breast cancer therapi intern extern stress proven substanti facilit breast cancer progress molecular system mechan exampl endoplasm reticulum stress er result activ unfold protein respons upr consid import cellular stress respons report indic key role protein homeostasi divers function involv process breast cancer progress therefor therapi target activ er downstream signal pathway potenti help novel tool counteract fight breast cancer howev recent advanc understand er focus character modul er healthi diseas state littl attent paid studi role clinic applic target er certain cancer review summar function main mechan er differ molecular type breast cancer focus develop agent target er provid new treatment strategi breast cancer video abstract	D059865;D001943	T049;T191
36,345,015	sever abacavir hypersensit reaction patient human immunodefici virus infect case report abacavir nucleosid revers transcriptas inhibitor use compon antiretrovir treatment regimen manag human immunodefici virus adult children efficaci use may limit hypersensit reaction link hla b genotyp hla b report rare african popul natur present abacavir hypersensit prone late diagnosi treatment especi set hla b genotyp routin done	D015658;D019380;D004342	T121;T047;T046
36,345,013	corticotropin stimul steroid profil predict shock develop mortal sepsi hypress studi steroid profil combin corticotropin stimul test provid inform steroidogenesi function reserv critic ill patient	D018805;D012772	T047;T046
36,345,011	custom gene express panel evalu potenti molecular marker hepatocellular carcinoma hepatocellular carcinoma hcc second lead caus cancer relat mortal worldwid high heterogen diseas poor prognosi limit treatment option highlight need reliabl biomark studi aim explor molecular marker allow stratif hcc may lead better prognosi treatment predict	D006528;D008113	T191
36,345,010	attract repuls effect sensori histori concurr shape visual percept sequenti effect environment stimuli ubiquit behavior task involv magnitud estim memori decis make emot human visual system exploit continu visual environ induc two contrast perceptu phenomena shape visual percept previous work report perceptu estim stimulus may influenc either attract serial depend repuls aftereffect number experiment variabl suggest factor determin direct magnitud sequenti effect recent studi theoriz two effect concurr aris perceptu process empir evid direct support hypothesi lack remain unclear whether attract repuls sequenti effect interact trial show two effect concurr modul estim behavior typic sequenc perceptu task	D003657;D014796	T041
36,345,008	univers predict mechanist urinari peptid signatur acut kidney injuri delay diagnosi acut kidney injuri aki episod lack specif current singl aki biomark hamper manag urinari peptidom analysi may help identifi earli molecular chang aki grasp complex identifi potenti target molecular pathway	D058186	T047;T037
36,345,007	map respons genom element heat stress maiz divers panel mani plant speci exhibit genet variat cope environment stress howev still limit approach effect uncov genom region regul distinct respons pattern gene across multipl varieti within speci abiot stress	D003313;D018506	T045;T168;T002
36,345,005	prepar pandem systemat review pandem influenza clinic manag guidelin covid pandem highlight import evid base clinic decis make clinic manag guidelin cmgs may help reduc morbid mortal improv qualiti clinic decis systemat review aim evalu avail inclus qualiti pandem influenza cmgs identifi gap address strengthen pandem prepared area	D007251;D000086382	T047;T067
36,345,004	comparison immunotherapi efficaci earli non small cell lung cancer advanc non small cell lung cancer systemat review current immunotherapi wide use treatment various stage non small cell lung cancer accord clinic experi result previous studi immunotherapi neoadjuv therapi seem exhibit better efficaci earli resect non small cell lung cancer compar advanc lung cancer often defin unresect non small cell lung cancer howev observ establish clinic studi systemat review aim evalu efficaci immunotherapi earli late lung cancer wherein object respons rate orr diseas control rate dcr use evalu index present studi also evalu safeti immunotherapi earli late lung cancer wherein rate treatment relat advers reaction trae use indic	D002289;D008175	T191
36,345,003	radiat dose escal local advanc nasopharyng carcinoma patient local andor region residu lesion standard chemoradiotherapi non random observ studi assess effect toxic radiat dose escal local advanc nasopharyng carcinoma la npc patient local andor region residu lesion standard treatment	D009303;D020031;D002277	T047;T191
36,345,002	outcom follow local inject liquid amnion allograft treatment equin tendon desmiti case tendon ligament injuri signific caus loss use earli retir perform hors amniot fluid tissu excel sourc growth factor cytokin import tendon ligament heal thus equin origin liquid amnion allograft elaa may benefici treatment equin tendon desmiti object studi report outcom achiev ie abil return work hors diagnos tendon desmiti lesion treat local inject elaa compar outcom report regen medicin modal	D006734;D052256	T047
36,344,999	self esteem mediat associ perfection mind among lebanes univers student evalu associ mind self esteem perfection lebanes sampl univers student well indirect effect self esteem mind perfection investig	D000072639;D064866	T033;T041
36,344,998	achiev malaria test treatment target children five mozambiqu cost effect analysi entir popul mozambiqu risk malaria remain one lead caus death nation malaria strateg plan focus reduc malaria morbid mortal high low transmiss area studi aim estim cost health benefit six variat world health organ test treat strategi among children five	D008288	T047
36,344,996	participatori map address neighborhood level data defici food secur assess southeastern virginia usa food equit avail defici general limit nation dataset food secur assess intervent addit neighborhood level studi need develop scalabl transfer process complement nation intern compar data set time granular nuanc data participatori geograph inform system pgis offer mean address issu digit local knowledg	D005523;D012111	T078;T082;T083;T033;T056;T096;T081
36,344,995	network reconstruct tran act genet loci use multi omic data prior inform molecular measur genom transcriptom epigenom often term multi omic data provid depth view biolog system integr crucial gain insight complex regulatori process data use explain diseas relat genet variant link intermedi molecular trait quantit trait loci qtl molecular network regul cellular process leav footprint qtl result call tran qtl hotspot reconstruct network complex endeavor use biolog prior inform improv network infer howev previous effort limit type prior use appli model system studi reconstruct regulatori network under tran qtl hotspot use human cohort data data driven prior inform	D040641;D059467	T081;T028;T086
36,344,994	challeng opportun general practic specif cme europ narrat review seven countri sever chang led general practition gps work differenti set today support health profess practic chang primari care specif continu medic educ cme may also need adapt compar differ primari care specif cme approach gps across europ aim identifi challeng opportun futur develop	D058006;D058005	T091;T097
36,344,993	genom wide associ studi mammograph textur variat breast parenchym textur featur includ grayscal variat v captur pattern textur variat mammogram associ breast cancer risk independ mammograph densiti md howev knowledg genet basi textur featur limit	D055106;D009369	T063;T191
36,344,992	cancer deriv extracellular succin driver cancer metastasi succin tricarboxyl acid tca cycl intermedi normal confin mitochondri matrix substrat succin dehydrogenas sdh mutat sdh subunit sdhd sdhb hereditari tumor paraganglioma reduct sdhb express cancer result matrix succin accumul transport cytoplasma secret extracellular milieu excess cytosol succin known stabil hypoxia induc factor hif inhibit prolyl hydroxylas recent report indic cancer secret succin enhanc cancer cell migrat promot cancer metastasi activ succin receptor sucnr mediat signal transcript pathway cancer deriv extracellular succin enhanc cancer cell macrophag migrat sucnr pi k hif pathway extracellular succin induc tumor angiogenesi sucnr mediat erk stat activ result upregul vascular endotheli growth factor vegf express succin increas sucnr express cancer cell consid target develop new anti metastasi drug furthermor serum succin elev cancer patient may theranost biomark select patient sucnr antagonist therapi	D010235;D019802	T121;T191;T109
36,344,989	deep learn ct imag segment cervic cancer systemat review meta analysi paper attempt conduct systemat review meta analysi deep learn dls model cervic cancer ct imag segment	D000077321;D002583	T191;T066
36,344,987	random doubl blind placebo control crossov trial oral doxycyclin epistaxi hereditari hemorrhag telangiectasia vascular malform hereditari hemorrhag telangiectasia hht lead chronic recurr bleed hemorrhag stroke heart failur liver diseas great interest identifi novel therapi epistaxi hht given associ morbid impact qualiti life aim measur effect oral doxycyclin treatment epistaxi explor mechan action angiogen inflammatori pathway marker hht use random control trial	D013683;D000086382	T047;T067
36,344,986	use integr evid decis framework develop recommend induct labour priorit updat recommend relat three labour induct topic labour induct beyond term mechan method labour induct outpati labour induct part process aim review evid address factor beyond clinic effect valu human right sociocultur accept health equiti econom feasibl consider inform guidelin develop group decis make use integr evid decis framework reflect method identifi synthes integr evid could improv	D019317;D006297	T033;T091;T080
36,344,985	gender composit wage gap canadian health polici research workforc compar perspect gender challeng shown persist among health practition countri level develop less known non clinic profession deliv servic direct essenti health system perform health polici research nation observ studi examin gender occup segreg wage gap canadian health polici research workforc use cross domain compar labour market analysi approach	D012456;D006280	T081
36,344,984	predict amyloid pet posit via machin learn algorithm train edta base blood amyloid oligomer data tendenc amyloid form oligom blood measur multim detect system oligomer amyloid mds oa valuabl biomark alzheim diseas verifi heparin base plasma object studi evalu perform ethylenediaminetetraacet acid edta base mds oa develop machin learn algorithm predict amyloid positron emiss tomographi pet posit	D000544;D060825	T047;T048
36,344,983	comprehens clinic evalu tomoeqa patient specif pre treatment qualiti assur helic tomotherapi base previous studi feasibl tomoeqa exit detector base patient specif pre treatment qualiti assur qa method helic tomotherapi depth clinic evalu conduct	D050397	T061
36,344,982	denisovan neanderth archaic introgress differenti impact genet complex trait modern popul introgress extinct neanderth denisovan human speci shown contribut genet pool modern human popul phenotyp spectrum evid neanderth introgress shape genet human trait diseas extens studi popul european descent signatur admixtur report instanc gene associ pigment immun metabol trait howev limit inform current avail impact archaic introgress ancestri group addit date studi conduct respect impact denisovan introgress health diseas modern popul compar way evolutionari pressur shape genet complex trait east asian european popul provid evid impact denisovan introgress health east asian centralsouth asian popul	D059125	T015
36,344,981	associ matern levothyroxin use pregnanc offspr birth neurodevelopment outcom popul base cohort studi influenc matern levothyroxin treatment pregnanc remain unclear studi aim evalu associ matern levothyroxin treatment pregnanc birth neurodevelopment outcom offspr	D047928;D000067877;D011297;D001289	T046;T037;T048
36,344,980	videofluoroscop swallow studi train radiologist train survey practic train need lack formal publish videofluoroscop swallow studi vfss train target radiologist yet radiolog senior medic offic resid medic offic ie radiologist train known australia registrar expect involv vfss interpret anatom anomali report studi investig whether vfss train deliv registrar specialist radiolog train whether perceiv need determin desir content inclus target train packag	D003680	T047
36,344,978	number risk factor target associ cardiovascular risk type diabet popul albuminuria primari cardiovascular prevent post hoc analysi nid trial nephropathi diabet type nid studi open label cluster random clinic trial demonstr multifactori intens treatment reduc major advers cardiac event mace overal mortal versus standard care type diabet subject albuminuria histori cardiovascular diseas aim present post hoc analysi nid studi evalu whether number risk factor target associ patient outcom	D003924;D002318;D003928	T047
36,344,977	novel like pathogen variant fbxo gene associ dilat cardiomyopathi accord wholeexom sequenc famili dilat cardiomyopathi dcm genet heart disord character progress heart failur sudden cardiac death gene report associ dcm nonetheless genet caus dcm patient unknown goal present studi determin genet etiolog famili dcm iranian famili	D002311	T047
36,344,975	distanc sport facil low frequenc exercis obes cross section studi littl research investig associ proxim physic activ facil behavior relat health major focus proxim home address add literatur examin proxim facil work home address includ wide rang physic activ facil assess associ proxim physic activ facil home work address self report frequenc exercis obes	D015444;D009765	T061;T056;T047
36,344,974	upregul mir p associ reduc type reductas express benign prostat hyperplasia reductas inhibitor ari first line drug manag benign prostat hyperplasia bph unfortun patient respond ari therapi may even show worsen symptom decreas express steroid reductas type srda bph tissu may explain failur ari therapi howev mechan under srda decreas remain unelucid	D011470;D035683	T123;T047;T191;T114
36,344,973	school water sanit hygien wash intervent improv malnutrit dehydr health literaci handwash cluster randomis control trial metro manila philippin impact multicompon school water sanit hygien wash intervent children health unclear conduct cluster random control trial test effect school wash intervent children malnutrit dehydr health literaci hl handwash hw metro manila philippin	D057220;D044342;D044343	T047;T041
36,344,972	posterior microphthalmo achiev good visual acuiti disappear papillomacular retin fold case report posterior microphthalmo pm rare condit poor visual prognosi even amblyopia treatment report case pm achiev good visual acuiti disappear papillomacular retin fold pfs period year	D008850;D000550;D012164	T019;T047
36,344,971	nonconform gender express insuffici sleep among adolesc covid school closur school reopen gender nonconform gnc ie gender express differ gender role expect feminin masculin appear behavior research area adolesc sleep health covid lockdown offer opportun understand effect gnc adolesc health outcom chang school closur reopen	D012892;D000086382	T033;T047;T046;T067
36,344,970	water sanit hygien practic health nutrit status among children covid pandem longitudin evid remot area dailekh achham district nepal covid pandem drew hygien center diseas prevent provis adequ water sanit hygien wash servic crucial protect public health pandem yet access level water suppli support adequ hygien measur defici mani area nepal examin wash practic impact child health nutrit status two district covid pandem	D000086382;D044342	T047;T067
36,344,969	photoselect sharp enucl prostat front fire nm laser versus photoselect vapor prostat treatment benign prostat hyperplasia randomis control trial year followup result design new surgic procedur treat benign prostat hyperplasia bph order verifi effect safeti construct random control trial compar efficaci innov enucl techniqu photoselect sharp enucl prostat psep front fire nm laser tradit techniqu photoselect vapor prostat pvp treatment bph	D011470;D020728;D053685;D053844	T061;T073;T191;T047;T074
36,344,968	nt probnp mortal across spectrum glucos toler general us popul even though hyperglycemia well known cardiovascular risk factor absolut risk cardiovascular event vari great extent within glycem categori aim studi evalu whether n termin pro b natriuret peptid nt probnp could help identifi subject higher cardiovascular risk independ blood glucos level	D020097;D006333	T123;T121;T116;T125;T047;T046
36,344,967	haplotyp resolv genom assembl nile rat facilit explor genet basi diabet nile rat avicanthi niloticus import anim model robust diurnal rhythm cone rich retina propens develop diet induc diabet without chemic genet modif closer similar human aspect compar wide use mus musculus rattus norvegicus model hold promis better translat research find clinic	D003924	T047
36,344,966	visual outcom epiretin membran remov diffract type multifoc intraocular len implant assess visual outcom epiretin membran erm remov multifoc intraocular len miol implant eye accord erm stage	D000075542;D019773;D007910;D018918	T061;T047;T074;T020
36,344,965	propens score match studi robot assist radic cystectomi older patient comparison intracorpor ileal conduit cutan ureterostomi robot assist radic cystectomi rarc intracorpor urinari divers less invas convent procedur howev older patient cutan ureterostomi cus may prefer urinari divers use intestin high incid periop complic high invas purpos studi demonstr safeti efficaci intracorpor ileal conduit icic compar cus patient age year older underw rarc	D012371;D001749;D014547;D065287	T061;T090;T191
36,344,964	quantit cross section studi assess surgic traine percept oper room educ environ limit hour servic provis diminish train opportun whilst increas standard surgic profici sought imper maximis valu educ event object measur higher surgic traine percept oper room environ england perform steer futur chang optimis educ event theatr oper room educ environ measur oreem evalu compon learn environ enabl optimis educ event howev oreem yet assess reliabl higher surgic traine england aim current studi explor area strength weak educ environ oper room perceiv surgic traine one english region secondari aim assess reliabl oreem	D009873;D007396	T065;T097;T073;T093
36,344,963	associ self report mobil phone usag blood pressur heart rate evid cross section studi advanc technolog rate access use mobil phone differ communiti increas signific mobil phone emit electromagnet wave therefor excess use may harm effect physic mental health especi cardiovascular system studi aim investig associ self report mobil phone use durat blood pressur heart rate hr use data ravansar non communic diseas rancd cohort studi	D040421	T073
36,344,962	retin telangiectasia like lesion year old femal hereditari hemorrhag telangiectasia case report hereditari hemorrhag telangiectasia hht also known rendu osler weber syndrom bleed disord affect part bodi includ eye differ ocular abnorm describ relat hht pathogenesi retin involv still unknown case describ chorioretin abnorm primarili occur elder patient studi present uniqu case young femal known hht seri retin fundus imag includ optic coher tomographi oct optic coher tomographi angiographi octa macular telangiectasia like lesion	D013683;D003930	T047
36,344,961	effect differ teachinglearn approach use virtual patient student situat interest cognit load compar studi virtual patient vps receiv consider attent medic educ authent learn teach approach studi aim evalu effect use differ approach conduct virtual patient vps student cognit load situat interest	D000066908;D004504	T065
36,344,960	improv sens citi belong among migrant elder follow famili elder servic perspect cross section studi migrant elder follow famili meff migrat new communiti reunit famili may face challeng citi integr belong studi aim explor elder servic perspect improv sens citi belong meff without hypertensiondiabet condit	D014171;D006973	T047;T098
36,344,959	prognost factor treatment gastric mucos atyp hyperplasia endoscop submucos dissect endoscop submucos dissect esd becom increas popular treatment precancer lesion earli cancer stomach howev studi factor associ recurr precancer lesion esd	D000069916;D013274;D011230	T061;T191
36,344,958	associ decreas ipsilater renal function aggress behavior renal cell carcinoma assess prognost valu pre oper ipsilater split renal function srf diseas free surviv dfs associ aggress patholog featur renal cell carcinoma rcc patient method examin patient regist snug rcc nx underw partial radic nephrectomi seoul nation univers hospit januari decemb patient follow criteria exclud studi non kidney origin cancer benign renal tumor pre oper tc dtpa renal scan singl kidney status previous partial radic nephrectomi bilater renal mass final patient includ	D002292;D007680	T191
36,344,957	hidden blood loss influenc factor minim invas percutan transpedicular screw fixat thoracolumbar fractur minim invas percutan transpedicular screw fixat miptsf general accept minim invas treatment thoracolumbar fractur howev hidden blood loss hbl caus procedur usual disregard studi aim investig amount hbl influenc factor miptsf thoracolumbar fractur	D016103;D065289	T074;T037
36,344,956	assess earli kidney injuri caus asymptomat bacteriuria children type diabet infect one frequent caus morbid mortal diabet patient microorgan becom virul high glucos concentr diabet like asymptomat symptomat bacteriuria ngal secret high concentr blood urin within two hour aki	D001437;D003922;D058186	T047;T037
36,344,955	pulmonari scleros pneumocytoma mortal risk surgic resect usual recommend treatment pulmonari scleros pneumocytoma psp howev compar studi demonstr surgic resect lead improv outcom aim compar caus mortal patient psp underw surgeri without psp	D047868	T191
36,344,954	increas volum cerebr oedema associ risk acut seizur activ advers neurolog outcom enceph region volumetr analysi multi centr cohort seizur occur unpredict patient acut enceph syndrom ae mani suffer poor long term neurolog sequela establish factor associ acut seizur risk poor outcom could support clinic care aim conduct region volumetr analysi cerebr oedema magnet reson imag mri patient ae assess relationship brain oedema acut seizur activ long term neurolog outcom	D001929;D020803	T047;T046
36,344,953	examin relationship trust provid inform mistrust covid vaccin concern necess intent facilit maximum uptak covid vaccin role medic trust mistrust healthcar profession must examin previous work suggest trust mistrust may differenti impact vaccin intent via vaccin necess concern multigroup structur equat model util test whether vaccin necess concern mediat associ trust provid health inform mistrust provid willing get covid vaccin model found invari across black white respond trust provid trust healthcar inform exert indirect effect intent vaccin necess mistrust provid exert indirect effect vaccin concern unlik previous work form trust influenc vaccin concern find implic futur communic effort healthcar profession health messeng	D000086382;D014612	T129;T121;T116;T067;T047
36,344,952	letrozol induc endometri prepar improv pregnanc outcom frozen blastocyst transfer compar natur cycl retrospect cohort studi letrozol treatment consid effect option endometri prepar frozen embryo transfer patient ovul disord irregular menstruat howev effect letrozol induc endometri prepar remain unclear ovulatori patient furthermor compar studi report pregnanc complic congenit anomali frozen embryo transfer compar natur letrozol assist cycl studi examin whether letrozol induc endometri prepar affect pregnanc outcom perinat outcom congenit anomali singl vitrifi warm blastocyst transfer svbts ovulatori patient compar natur cycl	D011256;D011248	T033;T046
36,344,951	comparison widefield swept sourc optic coher tomographi angiographi ultra widefield fluorescein angiographi evalu lesion retin vein occlus compar widefield swept sourc optic coher tomographi angiographi ss octa ultra widefield fundus fluorescein angiographi uwf fa detect retin vein occlus rvo lesion	D041623;D012170	T060;T047;T046
36,344,950	public prefer regard prioriti set criteria health intervent budget alloc result survey iranian adult prioriti set health direct impact general public payer final consum public prefer must consid present studi aim provid public prefer health intervent alloc criteria optim alloc public health budget iran	D002017	T170;T057
36,344,949	compar genom examin endophyt potenti pantoea agglomeran dapp pg pantoea agglomeran dapp pg isol endophyt knot tumor caus pseudomona savastanoi pv savastanoi dapp pg oliv tree understand plant pathogen endophyt interact genom level whole genom p agglomeran dapp pg sequenc annot complet genom total size bp contain one circular chromosom four larg circular plasmid aim studi identifi genom featur could play potenti role interact p agglomeran dapp pg p savastanoi pv savastanoi dapp pg purpos compar genom analysi genom p agglomeran dapp pg relat pantoea spp carri p agglomeran dapp pg gene cluster synthesi hrp type iii secret system tss type vi secret system tss autoinduc could play import role plant pathogen communiti enhanc knot format oliv tree identifi addit gene cluster biosynthesi two differ antibiot name dapdiamid e antibiot b found region integr conjug element ice observ depth analysi whole genom suggest character p agglomeran dapp pg isol endophyt bacterium biocontrol activ rather plant pathogen	D020636;D031658	T168;T007;T002
36,344,948	preval pattern mutat rasrafmekerkmapk signal pathway colorect cancer north africa review discuss find analyz data examin kras nras braf mutat patient colorect cancer crc north africa compar preval shown popul ii possibl role dietari lifestyl factor crc risk method use electron databas systemat literatur search perform kras nras braf mutat crc patient morocco tunisia algeria lybia result seventeen studi identifi electron search six studi conduct morocco eight tunisia two algeria one libya total crc patient includ morocco tunisia algeria libya overal averag age patient year old patient predomin male mutat rate kras nras braf patient respect broad rang report kras mutat frequenc report north africa countri kras mutat frequenc morocco tunisia algeria libya gd frequent identifi kras exon mutat follow gv gd gc ga gs gr gv gc gr less import differ among north africa countri morocco tunisia higher preval gd mutat kras exon frequent mutat type kras exon ql qe mutat also found kras exon common mutat follow kn ap av	D048493;D015179	T191;T126;T116
36,344,947	lncrna meg promot cisplatin sensit cervic cancer cell regul mir pten axi cervic cancer cc common gynecolog malign worldwid patient perform serious resist chemotherapi long strand non code rna meg report involv regul chemoresist mani solid tumor howev involv cervic adenocarcinoma report	D062085;D002583;D035683	T123;T191;T114
36,344,946	high densiti lipoprotein cholesterol efflux capac patient obstruct sleep apnea relat diseas sever obstruct sleep apnea osa link acceler risk cardiovascular diseas cvd key cvd risk factor present patient suffer osa hypertens inflamm oxid stress dyslipidemia high densiti lipoprotein hdl cholesterol efflux capac cec propos reliabl biomark hdl function present studi aim quantifi biomark patient osa	D002318;D020181	T047
36,344,945	risk analysi grade radiat pneumon base radiotherapi timelin stage iiiiv non small cell lung cancer treat volumetr modul arc therapi retrospect studi radiotherapi import treatment patient stage iiiiv non small cell lung cancer nsclc due high incid radiat pneumon essenti identifi high risk peopl earli possibl present work investig valu applic differ phase data throughout radiotherapi process analyz risk grade radiat pneumon stage iiiiv nsclc furthermor phase data fusion gradual perform radiotherapi timelin develop risk assess model	D002289;D017564;D050397;D008175;D011014	T061;T050;T191;T037;T047
36,344,944	analges effect arthrit chang follow intra articular inject diclofenac etalhyaluron rat knee osteoarthr model diclofenac etalhyaluron df ha recent develop analges conjug diclofenac hyaluron acid analges anti inflammatori effect acut arthriti studi investig analges effect osteoarthr use rat model monoiodoacet mia	D004008;D020370	T121;T047;T109
36,344,942	high risk hpv infect associ hypermethyl gene oropharyng squamous cell carcinoma hpv posit oropharyng squamous cell carcinoma opscc sensit chemo radiat therapi favor surviv outcom compar hpv negat cancer tumor usual relat tobacco alcohol exposur therefor diagnos hpv posit opscc appropri diseas manag crucial suitabl marker avail detect earli malign hpv infect tissu studi attempt find hpv specif epigenet biomark opscc	D009959;D030361;D002294;D009856;D006258	T123;T047;T191;T116
36,344,941	explor util accept faecal immunochem test fit novel intervent improv colorect cancer crc surveil individu lynch syndrom fit lynch studi singl arm prospect multi centr non randomis studi lynch syndrom ls inherit cancer predisposit syndrom defin pathogen variant mismatch repair mmr epcam gene unit kingdom peopl ls advis undergo biennial colonoscopi earli year age mitig high lifetim colorect cancer crc risk though consider addit surveil intervent applic non invas diagnost devic yet longitudin observ ls patient studi examin role annual faecal immunochem test fit alongsid biennial colonoscopi crc surveil peopl ls	D003123;D015179	T047;T191
36,344,940	effect n acetylcystein patient non cystic fibrosi bronchiectasi nincfb studi protocol multicentr doubl blind randomis placebo control trial n acetylcystein nac specif involv airway mucus clearanc antioxid recommend treatment guidelin non cystic fibrosi bronchiectasi ncfb howev littl clinic evid long term efficaci concern qualiti life qol exacerb patient ncfb addit influenc nac airway bacteri colon chronic inflamm oxid stress ncfb also unclear	D001987;D003550	T047
36,344,939	unlock molecular basi wheat straw composit morpholog trait multi locus gwas rapid reduct emiss fossil fuel burn need curb global climat chang biofuel product crop residu contribut reduc energi crisi environment deterior wheat renew sourc biofuel owe low cost high avail residu thus identifi candid gene control trait pivot effici biofuel product six multi locus genom wide associ ml gwas model appli use tetraploid wheat access detect quantit trait nucleotid qtns fifteen trait associ biomass composit	D014908;D055106	T063;T168;T002
36,344,938	covid vaccin hesit short term long term intent among unvaccin young adult mix method approach american year old fulli vaccin covid june grand fork counti north dakota face similar challeng june individu year old age group vaccin focus unvaccin individu studi aim understand way receiv covid vaccin constru use qualit interview studi compar predictor short term vaccin intent ie next month long term vaccin intent ie three year use onlin survey	D033182;D000086382	T047;T067;T041
36,344,937	impact care elder certif ad compet famili physician practic result pan canadian multipl case studi famili physician serv import role care older adult variabl level train comfort navig complex patient popul care elder coe certif ad compet offer colleg famili physician canada recogn famili physician advanc expertis older adult healthcar explor coe train certif impact primari care deliveri older patient includ factor impact group practic	D010821;D005194	T091;T097
36,344,936	physcomitrium paten cad distinct role growth resist biotic stress physcomitrium paten provid evolutionari link green alga vascular plant although genom p paten includ ortholog core lignin biosynthet enzym occurr lignin moss controversi besid littl inform avail lignin enzym moss date exampl cinnamyl alcohol dehydrogenas cad crucial enzym catalyz last step lignin biosynthet pathway suggest ideal way studi evolutionari process investig function cad evolut studi elucid evolutionari role lignin like earli stage land colon	D019068;D017360	T002
36,344,934	predict hiv proteas cleavag site octapeptid sequenc inform use select classifi hybrid descriptor part world especi underdevelop countri acquir immunodefici syndrom aid still remain major caus death disabl unfavor econom outcom necessit intens research develop effect therapeut agent treatment human immunodefici virus hiv infect respons aid peptid cleavag hiv proteas essenti step replic hiv thus correct time predict cleavag site hiv proteas signific speed optim drug discoveri process novel hiv proteas inhibitor work built compar perform select machin learn model predict hiv proteas cleavag site util hybrid octapeptid sequenc inform compris bond composit amino acid binari profil aabp physicochem properti numer descriptor serv input variabl select machin learn algorithm work differ anteced studi explor subject combin octapeptid descriptor method use instead use various subset dataset train test model combin dataset appli way data split use stratifi fold cross valid techniqu alongsid test set evalu model	D015497;D000163;D015658	T005;T047
36,344,933	nomogram predict sever communiti acquir pneumonia develop diabet patient multicent studi diabet patient communiti acquir pneumonia cap increas risk progress sever cap essenti develop predict tool onset diseas earli identif intervent studi aim develop valid clinic featur base nomogram identifi diabet patient cap risk develop sever cap	D017714;D011014;D003920	T047;T050
36,344,932	predict syntax score ii improv ad tempor heart rate chang discharg first outpati visit patient acut myocardi infarct prognost abil tempor chang rest heart rate hr patient acut myocardi infarct ami cardiovascular cv mortal clinic outcom rare examin studi investig predict valu hr use model syntax score ii sxs ii long term prognosi patient ami	D010351;D009203	T058;T047
36,344,931	associ five obes indic cognit perform taiwan biobank particip obes advers influenc central nervous system cognit function howev relationship various obes indic cognit perform remain controversi unclear obes indic relev cognit impair	D056128;D018070	T033;T184;T093
36,344,930	prognost nomogram acut pancreat percutan biliari stent insert patient malign obstruct studi aim develop valid nomogram predict risk pancreat percutan transhepat biliari stent insert ptbs patient malign biliari obstruct mbo	D002779;D010195;D009369	T047;T046;T191
36,344,929	treatment earli borderlin lesion low immunolog risk kidney transplant patient spanish multicent random control parallel group studi protocol train studi subclin inflamm includ borderlin lesion bl common kidney transplant kt even low immunolog risk patient lead interstiti fibrosistubular atrophi ifta worsen renal function graft loss control studi analyz therapeut benefit treat bl renal function graft histolog furthermor studi use bolus steroid may insuffici slow progress lesion klotho transmembran protein produc main kidney antifibrot properti play crucial role senesc inflamm binomi kidney tissu system local inflamm decreas renal tissu express solubl level klotho therefor import determin whether treatment bl prevent decreas klotho level progress ifta loss kidney function	D016030;D007674	T061;T047
36,344,928	sparkec speed align base dna error correct tool recent year huge improv made context sequenc genom data call next generat sequenc ngs howev dna read generat current ngs platform free error affect qualiti downstream analysi although error correct perform preprocess step overcom issu usual requir long comput time analyz larg dataset generat nowaday ngs therefor new softwar capabl scale cluster node high perform great import	D012984;D059014	T063;T090;T073;T059;T170
36,344,927	associ treatment failur hospit receipt neutral monoclon antibodi treatment covid outpati neutral monoclon antibodi mab high effect reduc hospit mortal among earli symptomat covid patient clinic trial real world data resist mab sinc emerg among new variant characterist associ treatment failur mab remain unknown	D000086382	T047;T067
36,344,926	develop novel immun relat lncrna prognost signatur patient hepatocellular carcinoma hepatocellular carcinoma hcc common neoplasm major caus cancer associ death worldwid high mortal rate hcc main attribut widespread preval lack effect treatment immunotherapi promis innov approach revolutionis treatment solid tumour howev owe heterogen complex tumour microenviron hcc effici biomark immunotherapi yet identifi investig role immun relat long non code rnas lncrnas prognost biomark patient hcc cancer genom atlas tcga databas spearman correl univari multivari cox lasso regress analys utilis screen lncrnas associ prognosi four lncrnas filter develop immun associ lncrna prognost signatur tcga train well valid cohort patient hcc categoris low high risk group accord median valu risk score evalu abil prognost model train valid cohort nomogram base risk score stage construct apprais general overal surviv os patient hcc differ immun cell infiltr immun checkpoint inhibitor ici treatment respons gene mutat drug sensit observ two group thus lncrna prognost signatur serv sensit prognost biomark potenti individualis immunotherapi hcc patient	D006528;D062085;D008113	T123;T191;T114
36,344,924	comparison onset time durat action intub condit cisatracurium mgkg young elder patient tracheal intub anesthesia facilit neuromuscular block agent cisatracurium howev limit data exist onset time durat action effect intub condit elder patient year age hypothes elder patient would present longer onset time durat action compar younger adult	D015742;D009466	T121;T109
36,344,923	preval hepat b virus infect gulf cooper council systemat review meta analysi hepat b virus hbv infect global public health problem sinc introduct effect vaccin epidemiolog hbv infect chang aim estim preval hbv infect gulf cooper council gcc region delin variat member countri special sub group time	D006515;D006509	T005;T047
36,344,922	rna sequenc heterorhabd nematod identifi factor involv symbiosi photorhabdus bacteria nematod major group soil inhabit organ heterorhabd nematod insect pathogen nematod live close symbiot associ photorhabdus bacteria heterorhabd photorhabdus pair offer power genet tractabl model studi anim microb symbiosi possibl generat symbiont bacteria free axen stage heterorhabd compar transcriptom symbiot earli adult stage heterorhabd nematod axen earli adult nematod determin nematod gene pathway involv symbiosi photorhabdus bacteria	D020637;D017172	T007;T204
36,344,920	analysi ct mr imag featur brain patient hydrogen sulfid poison base clinic symptom grade retrospect analyz ct mr imag featur brain patient hydrogen sulfid poison base clinic symptom grade investig correl clinic symptom patient prognosi	D006862;D001929	T131;T197;T046;T130
36,344,919	cyclosporin therapi could consid membranoprolif glomerulonephr immunoglobulin deposit case report membranoprolif glomerulonephr mpgn rare glomerulonephr caus nephrot syndrom children often difficult treat typic immunofluoresc find includ strong c stain granular pattern along glomerular capillari wall negat iga stain iga domin mpgn without hypocomplementemia report herein report rare case mpgn hypocomplementemia predomin iga subclass deposit	D015432;D005921	T047
36,344,918	factor associ polypharmaci high risk medic relat problem among older communiti dwell adult european countri longitudin studi polypharmaci defin use five medic simultan medic relat problem extens polypharmaci includ inappropri prescrib poor adher overdosag underdosag inappropri drug select inadequ monitor advers drug effect drug interact polypharmaci high risk medic relat problem among older peopl associ advers health consequ due drug drug interact drug diseas interact advers drug effect studi aim assess factor associ polypharmaci high risk medic relat problem among communiti dwell older peopl netherland greec croatia spain unit kingdom	D019338;D064420	T061;T046;T037
36,344,917	compar studi dexmedetomidin versus fentanyl adjuv bupivacain ultrasound guid transversus abdomini plane block patient undergo radic cystectomi prospect randomis studi transversus abdomini plane tap block benefici pain manag conduct abdomin surgeri	D002045;D020927	T121;T109
36,344,916	individu dynam predict prognost analysi long term allograft surviv kidney transplant predict allograft surviv vital effici transplant success dynam chang patient condit clinic indic may chang longitudin doctor judgment may high variabl necessari establish dynam model precis predict individu risksurviv new allograft	D016030	T061
36,344,915	unveil hotspot genet divers southern itali endang hermann tortois testudo hermanni hotspot intraspecif genet divers repres invalu resourc speci cope environment chang identif increas recogn major goal conserv ecolog research howev even icon endang speci conserv strategi often plan without thorough inform geograph pattern genet variat investig spatial pattern genet variat endang hermann tortois testudo hermanni italian peninsula genotyp individu microsatellit loci aim contribut plan effect conserv strategi	D014426	T014
36,344,914	magnet reson imag parotid gland tumor pictori essay imag parotid gland tumor challeng due wide varieti differenti diagnos malign parotid tumor similar featur benign one slow growth displac instead infiltr neighbor structur malign benign tumor may therefor clinic distinguish correct character parotid tumor ie benign malign determin preoper treatment plan import optim individu surgic plan magnet reson imag mri imag modal choic evalu suspect parotid gland lesion differenti benign malign lesion certain convent mri featur suggest whether mass like benign low grade malign high grade malign ad diffus weight imag advanc mri techniqu like perfus aid distinct morpholog featur seen mri low signal w infiltr chang ill defin margin chang time diffus restrict point malign natur lesion mri use detect local lesion associ find like perineur spread tumor lymph node involv infiltr chang surround tissu pictori essay present select imag varieti benign malign parotid tumor emphas mri featur may use character	D010307	T191
36,344,913	duet snp assist structur variant call phase use oxford nanopor sequenc whole genom sequenc use long read oxford nanopor technolog ont minion sequenc provid cost effect option structur variant sv detect clinic applic despit advantag use long read howev accur sv call phase still challeng	D020641;D000081414	T063;T086
36,344,912	preval cardiometabol risk lifestyl factor young parent evid german birth cohort studi studi show parent signific impact children health cardiometabol risk profil health behavior littl inform preval cardiometabol risk factor lifestyl factor among new parent yet aim studi therefor evalu preval cardiometabol risk factor parent infant germani examin lifestyl health behavior	D003924;D006973	T047
36,344,911	circul season influenza virus differ transmiss zone africa influenza respons million sever case death everi year worldwid develop countri account influenza death children year age paper aim determin dynam influenza virus african transmiss area identifi region season appropri decis make develop region prepared respons strategi	D053118;D053122;D053124;D009981;D007251	T005;T047

36,345,029

effect analysi virtual simul experiment platform teach pulpotomi experiment teach pediatr dentistri bridg theoret studi clinic practic virtual simul technolog provid new method instruct

D011672;D007858

T061;T062;T041

36,345,028

acceler amyloid angiopathi relat vascular alter mix murin model alzheim diseas type two diabet age main risk factor alzheim diseas ad emerg evid suggest metabol alter type diabet td also major contributor inde sever studi describ close relationship ad td clinic evid show diseas coexist hallmark patholog event ad amyloid deposit brain either amyloid plaqu around leptomening cortic arteriol thus constitut cerebr amyloid angiopathi caa caa observ autopsi case ad contribut ad patholog limit perivascular drainag

D000544;D003924;D011236;D016657

T047;T048

36,345,027

fungal esophag associ tubercul pericard human immunodefici virus posit patient case report opportunist infect frequent peopl live human immunodefici virus either access antiretrovir therapi art use irregular tuberculosi frequent infecti diseas plhiv predispos patient sever fungal infect dire consequ

D010495;D002177;D009181;D004941

T047

36,345,026

gonadotropin releas hormon agonist preserv ovarian function survivor haematopoiet stem cell transplant haematolog diseas administr gnrh agonist gnrha prior chemotherapi may decreas risk gonad dysfunct patient tumor howev relev data haematopoiet stem cell transplant hsct recipi yet establish henc present studi design evalu clinic efficaci gnrha cotreat prior myeloabl regimen ovarian protect femal survivor hsct haematolog diseas

D016649;D008594;D006402;D018380

T061;T047

36,345,025

hand surgeri hand therapi clinic practic guidelin epidermolysi bullosa alreadi known topic epidermolysi bullosa eb caus blister scar hand result contractur fuse web space alter function surgeri need releas contractur web space hand therapi essenti maintain result approach differ studi add guidelin aim provid inform surgic conserv therapeut hand manag children adult diagnos eb base avail evid expert consensus assist hand surgeon therapist decis make plan treatment highlight import holist multidisciplinari team mdt approach patient prioriti paramount

D004820;D003286;D016108

T019;T047;T190

36,345,023

influenc covid year carbon footprint nagoya univers hospit medic research centr amidst climat crisi key goal medic sector reduc larg carbon footprint although coronavirus diseas covid pandem great impact medic sector influenc carbon footprint remain unknown therefor aim studi evalu chang carbon footprint univers hospit medic research centr past year

D000086382;D035843

T062;T047;T067

36,345,021

impact set new medic school narrat review growth uk popul togeth age societi increas complex health social care need place greater demand statutori care servic view emerg landscap uk govern sought increas medic train workforc order better respond demand place health servic five univers announc home new medic school offer undergradu place boost number doctor train england aim narrat review explor new medic school could improv health outcom local popul evalu potenti contribut may make local economi workforc research innov

D012577;D019035

T058;T073;T093

36,345,020

addit extracorpor shock wave therapi improv effect isol percutan radiofrequ coblat patient insert achill tendinopathi studi protocol random control clinic trial conclus evid recommend prior treatment insert achill tendinopathi iat theoriz percutan radiofrequ coblat extracorpor shockwav therapi eswt reliev pain within insert howev clinic evid show either treatment promot regener tendon combin intervent offer better function less pain one therapi

D000074059;D000125;D052256;D019220

T061;T023;T070;T047

36,345,019

disrupt us local public health role popul base substanc use prevent respons covid covid dramat limit scale scope local health depart lhd work redirect resourc respons howev need essenti public health servic includ substanc use prevent reduc

D000086382;D019966

T033;T047;T067;T048

36,345,018

reimplant approach anomal aortic origin right coronari arteri aberr right subclavian arteri anomal aortic origin right coronari arteri rare diseas although various report treatment method surgic approach still controversi present rare case year old man anomal aortic origin right coronari arteri aberr right subclavian arteri treatment underw reimplant right coronari arteri surgic approach anomal aortic origin right coronari arteri select consid age patient size right coronari arteri

D018376;D003330

T019

36,345,017

endoplasm reticulum stress target therapi breast cancer recurr metastasi drug resist still big challeng breast cancer therapi intern extern stress proven substanti facilit breast cancer progress molecular system mechan exampl endoplasm reticulum stress er result activ unfold protein respons upr consid import cellular stress respons report indic key role protein homeostasi divers function involv process breast cancer progress therefor therapi target activ er downstream signal pathway potenti help novel tool counteract fight breast cancer howev recent advanc understand er focus character modul er healthi diseas state littl attent paid studi role clinic applic target er certain cancer review summar function main mechan er differ molecular type breast cancer focus develop agent target er provid new treatment strategi breast cancer video abstract

D059865;D001943

T049;T191

36,345,015

sever abacavir hypersensit reaction patient human immunodefici virus infect case report abacavir nucleosid revers transcriptas inhibitor use compon antiretrovir treatment regimen manag human immunodefici virus adult children efficaci use may limit hypersensit reaction link hla b genotyp hla b report rare african popul natur present abacavir hypersensit prone late diagnosi treatment especi set hla b genotyp routin done

D015658;D019380;D004342

T121;T047;T046

36,345,013

corticotropin stimul steroid profil predict shock develop mortal sepsi hypress studi steroid profil combin corticotropin stimul test provid inform steroidogenesi function reserv critic ill patient

D018805;D012772

T047;T046

36,345,011

custom gene express panel evalu potenti molecular marker hepatocellular carcinoma hepatocellular carcinoma hcc second lead caus cancer relat mortal worldwid high heterogen diseas poor prognosi limit treatment option highlight need reliabl biomark studi aim explor molecular marker allow stratif hcc may lead better prognosi treatment predict

D006528;D008113

T191

36,345,010

attract repuls effect sensori histori concurr shape visual percept sequenti effect environment stimuli ubiquit behavior task involv magnitud estim memori decis make emot human visual system exploit continu visual environ induc two contrast perceptu phenomena shape visual percept previous work report perceptu estim stimulus may influenc either attract serial depend repuls aftereffect number experiment variabl suggest factor determin direct magnitud sequenti effect recent studi theoriz two effect concurr aris perceptu process empir evid direct support hypothesi lack remain unclear whether attract repuls sequenti effect interact trial show two effect concurr modul estim behavior typic sequenc perceptu task

D003657;D014796

T041

36,345,008

univers predict mechanist urinari peptid signatur acut kidney injuri delay diagnosi acut kidney injuri aki episod lack specif current singl aki biomark hamper manag urinari peptidom analysi may help identifi earli molecular chang aki grasp complex identifi potenti target molecular pathway

D058186

T047;T037

36,345,007

map respons genom element heat stress maiz divers panel mani plant speci exhibit genet variat cope environment stress howev still limit approach effect uncov genom region regul distinct respons pattern gene across multipl varieti within speci abiot stress

D003313;D018506

T045;T168;T002

36,345,005

prepar pandem systemat review pandem influenza clinic manag guidelin covid pandem highlight import evid base clinic decis make clinic manag guidelin cmgs may help reduc morbid mortal improv qualiti clinic decis systemat review aim evalu avail inclus qualiti pandem influenza cmgs identifi gap address strengthen pandem prepared area

D007251;D000086382

T047;T067

36,345,004

comparison immunotherapi efficaci earli non small cell lung cancer advanc non small cell lung cancer systemat review current immunotherapi wide use treatment various stage non small cell lung cancer accord clinic experi result previous studi immunotherapi neoadjuv therapi seem exhibit better efficaci earli resect non small cell lung cancer compar advanc lung cancer often defin unresect non small cell lung cancer howev observ establish clinic studi systemat review aim evalu efficaci immunotherapi earli late lung cancer wherein object respons rate orr diseas control rate dcr use evalu index present studi also evalu safeti immunotherapi earli late lung cancer wherein rate treatment relat advers reaction trae use indic

D002289;D008175

T191

36,345,003

radiat dose escal local advanc nasopharyng carcinoma patient local andor region residu lesion standard chemoradiotherapi non random observ studi assess effect toxic radiat dose escal local advanc nasopharyng carcinoma la npc patient local andor region residu lesion standard treatment

D009303;D020031;D002277

T047;T191

36,345,002

outcom follow local inject liquid amnion allograft treatment equin tendon desmiti case tendon ligament injuri signific caus loss use earli retir perform hors amniot fluid tissu excel sourc growth factor cytokin import tendon ligament heal thus equin origin liquid amnion allograft elaa may benefici treatment equin tendon desmiti object studi report outcom achiev ie abil return work hors diagnos tendon desmiti lesion treat local inject elaa compar outcom report regen medicin modal

D006734;D052256

T047

36,344,999

self esteem mediat associ perfection mind among lebanes univers student evalu associ mind self esteem perfection lebanes sampl univers student well indirect effect self esteem mind perfection investig

D000072639;D064866

T033;T041

36,344,998

achiev malaria test treatment target children five mozambiqu cost effect analysi entir popul mozambiqu risk malaria remain one lead caus death nation malaria strateg plan focus reduc malaria morbid mortal high low transmiss area studi aim estim cost health benefit six variat world health organ test treat strategi among children five

D008288

T047

36,344,996

participatori map address neighborhood level data defici food secur assess southeastern virginia usa food equit avail defici general limit nation dataset food secur assess intervent addit neighborhood level studi need develop scalabl transfer process complement nation intern compar data set time granular nuanc data participatori geograph inform system pgis offer mean address issu digit local knowledg

D005523;D012111

T078;T082;T083;T033;T056;T096;T081

36,344,995

network reconstruct tran act genet loci use multi omic data prior inform molecular measur genom transcriptom epigenom often term multi omic data provid depth view biolog system integr crucial gain insight complex regulatori process data use explain diseas relat genet variant link intermedi molecular trait quantit trait loci qtl molecular network regul cellular process leav footprint qtl result call tran qtl hotspot reconstruct network complex endeavor use biolog prior inform improv network infer howev previous effort limit type prior use appli model system studi reconstruct regulatori network under tran qtl hotspot use human cohort data data driven prior inform

D040641;D059467

T081;T028;T086

36,344,994

challeng opportun general practic specif cme europ narrat review seven countri sever chang led general practition gps work differenti set today support health profess practic chang primari care specif continu medic educ cme may also need adapt compar differ primari care specif cme approach gps across europ aim identifi challeng opportun futur develop

D058006;D058005

T091;T097

36,344,993

genom wide associ studi mammograph textur variat breast parenchym textur featur includ grayscal variat v captur pattern textur variat mammogram associ breast cancer risk independ mammograph densiti md howev knowledg genet basi textur featur limit

D055106;D009369

T063;T191

36,344,992

cancer deriv extracellular succin driver cancer metastasi succin tricarboxyl acid tca cycl intermedi normal confin mitochondri matrix substrat succin dehydrogenas sdh mutat sdh subunit sdhd sdhb hereditari tumor paraganglioma reduct sdhb express cancer result matrix succin accumul transport cytoplasma secret extracellular milieu excess cytosol succin known stabil hypoxia induc factor hif inhibit prolyl hydroxylas recent report indic cancer secret succin enhanc cancer cell migrat promot cancer metastasi activ succin receptor sucnr mediat signal transcript pathway cancer deriv extracellular succin enhanc cancer cell macrophag migrat sucnr pi k hif pathway extracellular succin induc tumor angiogenesi sucnr mediat erk stat activ result upregul vascular endotheli growth factor vegf express succin increas sucnr express cancer cell consid target develop new anti metastasi drug furthermor serum succin elev cancer patient may theranost biomark select patient sucnr antagonist therapi

D010235;D019802

T121;T191;T109

36,344,989

deep learn ct imag segment cervic cancer systemat review meta analysi paper attempt conduct systemat review meta analysi deep learn dls model cervic cancer ct imag segment

D000077321;D002583

T191;T066

36,344,987

random doubl blind placebo control crossov trial oral doxycyclin epistaxi hereditari hemorrhag telangiectasia vascular malform hereditari hemorrhag telangiectasia hht lead chronic recurr bleed hemorrhag stroke heart failur liver diseas great interest identifi novel therapi epistaxi hht given associ morbid impact qualiti life aim measur effect oral doxycyclin treatment epistaxi explor mechan action angiogen inflammatori pathway marker hht use random control trial

D013683;D000086382

T047;T067

36,344,986

use integr evid decis framework develop recommend induct labour priorit updat recommend relat three labour induct topic labour induct beyond term mechan method labour induct outpati labour induct part process aim review evid address factor beyond clinic effect valu human right sociocultur accept health equiti econom feasibl consider inform guidelin develop group decis make use integr evid decis framework reflect method identifi synthes integr evid could improv

D019317;D006297

T033;T091;T080

36,344,985

gender composit wage gap canadian health polici research workforc compar perspect gender challeng shown persist among health practition countri level develop less known non clinic profession deliv servic direct essenti health system perform health polici research nation observ studi examin gender occup segreg wage gap canadian health polici research workforc use cross domain compar labour market analysi approach

D012456;D006280

T081

36,344,984

predict amyloid pet posit via machin learn algorithm train edta base blood amyloid oligomer data tendenc amyloid form oligom blood measur multim detect system oligomer amyloid mds oa valuabl biomark alzheim diseas verifi heparin base plasma object studi evalu perform ethylenediaminetetraacet acid edta base mds oa develop machin learn algorithm predict amyloid positron emiss tomographi pet posit

D000544;D060825

T047;T048

36,344,983

comprehens clinic evalu tomoeqa patient specif pre treatment qualiti assur helic tomotherapi base previous studi feasibl tomoeqa exit detector base patient specif pre treatment qualiti assur qa method helic tomotherapi depth clinic evalu conduct

D050397

T061

36,344,982

denisovan neanderth archaic introgress differenti impact genet complex trait modern popul introgress extinct neanderth denisovan human speci shown contribut genet pool modern human popul phenotyp spectrum evid neanderth introgress shape genet human trait diseas extens studi popul european descent signatur admixtur report instanc gene associ pigment immun metabol trait howev limit inform current avail impact archaic introgress ancestri group addit date studi conduct respect impact denisovan introgress health diseas modern popul compar way evolutionari pressur shape genet complex trait east asian european popul provid evid impact denisovan introgress health east asian centralsouth asian popul

D059125

T015

36,344,981

associ matern levothyroxin use pregnanc offspr birth neurodevelopment outcom popul base cohort studi influenc matern levothyroxin treatment pregnanc remain unclear studi aim evalu associ matern levothyroxin treatment pregnanc birth neurodevelopment outcom offspr

D047928;D000067877;D011297;D001289

T046;T037;T048

36,344,980

videofluoroscop swallow studi train radiologist train survey practic train need lack formal publish videofluoroscop swallow studi vfss train target radiologist yet radiolog senior medic offic resid medic offic ie radiologist train known australia registrar expect involv vfss interpret anatom anomali report studi investig whether vfss train deliv registrar specialist radiolog train whether perceiv need determin desir content inclus target train packag

D003680

T047

36,344,978

number risk factor target associ cardiovascular risk type diabet popul albuminuria primari cardiovascular prevent post hoc analysi nid trial nephropathi diabet type nid studi open label cluster random clinic trial demonstr multifactori intens treatment reduc major advers cardiac event mace overal mortal versus standard care type diabet subject albuminuria histori cardiovascular diseas aim present post hoc analysi nid studi evalu whether number risk factor target associ patient outcom

D003924;D002318;D003928

T047

36,344,977

novel like pathogen variant fbxo gene associ dilat cardiomyopathi accord wholeexom sequenc famili dilat cardiomyopathi dcm genet heart disord character progress heart failur sudden cardiac death gene report associ dcm nonetheless genet caus dcm patient unknown goal present studi determin genet etiolog famili dcm iranian famili

D002311

T047

36,344,975

distanc sport facil low frequenc exercis obes cross section studi littl research investig associ proxim physic activ facil behavior relat health major focus proxim home address add literatur examin proxim facil work home address includ wide rang physic activ facil assess associ proxim physic activ facil home work address self report frequenc exercis obes

D015444;D009765

T061;T056;T047

36,344,974

upregul mir p associ reduc type reductas express benign prostat hyperplasia reductas inhibitor ari first line drug manag benign prostat hyperplasia bph unfortun patient respond ari therapi may even show worsen symptom decreas express steroid reductas type srda bph tissu may explain failur ari therapi howev mechan under srda decreas remain unelucid

D011470;D035683

T123;T047;T191;T114

36,344,973

school water sanit hygien wash intervent improv malnutrit dehydr health literaci handwash cluster randomis control trial metro manila philippin impact multicompon school water sanit hygien wash intervent children health unclear conduct cluster random control trial test effect school wash intervent children malnutrit dehydr health literaci hl handwash hw metro manila philippin

D057220;D044342;D044343

T047;T041

36,344,972

posterior microphthalmo achiev good visual acuiti disappear papillomacular retin fold case report posterior microphthalmo pm rare condit poor visual prognosi even amblyopia treatment report case pm achiev good visual acuiti disappear papillomacular retin fold pfs period year

D008850;D000550;D012164

T019;T047

36,344,971

nonconform gender express insuffici sleep among adolesc covid school closur school reopen gender nonconform gnc ie gender express differ gender role expect feminin masculin appear behavior research area adolesc sleep health covid lockdown offer opportun understand effect gnc adolesc health outcom chang school closur reopen

D012892;D000086382

T033;T047;T046;T067

36,344,970

water sanit hygien practic health nutrit status among children covid pandem longitudin evid remot area dailekh achham district nepal covid pandem drew hygien center diseas prevent provis adequ water sanit hygien wash servic crucial protect public health pandem yet access level water suppli support adequ hygien measur defici mani area nepal examin wash practic impact child health nutrit status two district covid pandem

D000086382;D044342

T047;T067

36,344,969

photoselect sharp enucl prostat front fire nm laser versus photoselect vapor prostat treatment benign prostat hyperplasia randomis control trial year followup result design new surgic procedur treat benign prostat hyperplasia bph order verifi effect safeti construct random control trial compar efficaci innov enucl techniqu photoselect sharp enucl prostat psep front fire nm laser tradit techniqu photoselect vapor prostat pvp treatment bph

D011470;D020728;D053685;D053844

T061;T073;T191;T047;T074

36,344,968

nt probnp mortal across spectrum glucos toler general us popul even though hyperglycemia well known cardiovascular risk factor absolut risk cardiovascular event vari great extent within glycem categori aim studi evalu whether n termin pro b natriuret peptid nt probnp could help identifi subject higher cardiovascular risk independ blood glucos level

D020097;D006333

T123;T121;T116;T125;T047;T046

36,344,967

haplotyp resolv genom assembl nile rat facilit explor genet basi diabet nile rat avicanthi niloticus import anim model robust diurnal rhythm cone rich retina propens develop diet induc diabet without chemic genet modif closer similar human aspect compar wide use mus musculus rattus norvegicus model hold promis better translat research find clinic

D003924

T047

36,344,966

visual outcom epiretin membran remov diffract type multifoc intraocular len implant assess visual outcom epiretin membran erm remov multifoc intraocular len miol implant eye accord erm stage

D000075542;D019773;D007910;D018918

T061;T047;T074;T020

36,344,965

propens score match studi robot assist radic cystectomi older patient comparison intracorpor ileal conduit cutan ureterostomi robot assist radic cystectomi rarc intracorpor urinari divers less invas convent procedur howev older patient cutan ureterostomi cus may prefer urinari divers use intestin high incid periop complic high invas purpos studi demonstr safeti efficaci intracorpor ileal conduit icic compar cus patient age year older underw rarc

D012371;D001749;D014547;D065287

T061;T090;T191

36,344,964

quantit cross section studi assess surgic traine percept oper room educ environ limit hour servic provis diminish train opportun whilst increas standard surgic profici sought imper maximis valu educ event object measur higher surgic traine percept oper room environ england perform steer futur chang optimis educ event theatr oper room educ environ measur oreem evalu compon learn environ enabl optimis educ event howev oreem yet assess reliabl higher surgic traine england aim current studi explor area strength weak educ environ oper room perceiv surgic traine one english region secondari aim assess reliabl oreem

D009873;D007396

T065;T097;T073;T093

36,344,963

associ self report mobil phone usag blood pressur heart rate evid cross section studi advanc technolog rate access use mobil phone differ communiti increas signific mobil phone emit electromagnet wave therefor excess use may harm effect physic mental health especi cardiovascular system studi aim investig associ self report mobil phone use durat blood pressur heart rate hr use data ravansar non communic diseas rancd cohort studi

D040421

T073

36,344,962

retin telangiectasia like lesion year old femal hereditari hemorrhag telangiectasia case report hereditari hemorrhag telangiectasia hht also known rendu osler weber syndrom bleed disord affect part bodi includ eye differ ocular abnorm describ relat hht pathogenesi retin involv still unknown case describ chorioretin abnorm primarili occur elder patient studi present uniqu case young femal known hht seri retin fundus imag includ optic coher tomographi oct optic coher tomographi angiographi octa macular telangiectasia like lesion

D013683;D003930

T047

36,344,961

effect differ teachinglearn approach use virtual patient student situat interest cognit load compar studi virtual patient vps receiv consider attent medic educ authent learn teach approach studi aim evalu effect use differ approach conduct virtual patient vps student cognit load situat interest

D000066908;D004504

T065

36,344,960

improv sens citi belong among migrant elder follow famili elder servic perspect cross section studi migrant elder follow famili meff migrat new communiti reunit famili may face challeng citi integr belong studi aim explor elder servic perspect improv sens citi belong meff without hypertensiondiabet condit

D014171;D006973

T047;T098

36,344,959

prognost factor treatment gastric mucos atyp hyperplasia endoscop submucos dissect endoscop submucos dissect esd becom increas popular treatment precancer lesion earli cancer stomach howev studi factor associ recurr precancer lesion esd

D000069916;D013274;D011230

T061;T191

36,344,958

associ decreas ipsilater renal function aggress behavior renal cell carcinoma assess prognost valu pre oper ipsilater split renal function srf diseas free surviv dfs associ aggress patholog featur renal cell carcinoma rcc patient method examin patient regist snug rcc nx underw partial radic nephrectomi seoul nation univers hospit januari decemb patient follow criteria exclud studi non kidney origin cancer benign renal tumor pre oper tc dtpa renal scan singl kidney status previous partial radic nephrectomi bilater renal mass final patient includ

D002292;D007680

T191

36,344,957

hidden blood loss influenc factor minim invas percutan transpedicular screw fixat thoracolumbar fractur minim invas percutan transpedicular screw fixat miptsf general accept minim invas treatment thoracolumbar fractur howev hidden blood loss hbl caus procedur usual disregard studi aim investig amount hbl influenc factor miptsf thoracolumbar fractur

D016103;D065289

T074;T037

36,344,956

assess earli kidney injuri caus asymptomat bacteriuria children type diabet infect one frequent caus morbid mortal diabet patient microorgan becom virul high glucos concentr diabet like asymptomat symptomat bacteriuria ngal secret high concentr blood urin within two hour aki

D001437;D003922;D058186

T047;T037

36,344,955

pulmonari scleros pneumocytoma mortal risk surgic resect usual recommend treatment pulmonari scleros pneumocytoma psp howev compar studi demonstr surgic resect lead improv outcom aim compar caus mortal patient psp underw surgeri without psp

D047868

T191

36,344,954

increas volum cerebr oedema associ risk acut seizur activ advers neurolog outcom enceph region volumetr analysi multi centr cohort seizur occur unpredict patient acut enceph syndrom ae mani suffer poor long term neurolog sequela establish factor associ acut seizur risk poor outcom could support clinic care aim conduct region volumetr analysi cerebr oedema magnet reson imag mri patient ae assess relationship brain oedema acut seizur activ long term neurolog outcom

D001929;D020803

T047;T046

36,344,953

examin relationship trust provid inform mistrust covid vaccin concern necess intent facilit maximum uptak covid vaccin role medic trust mistrust healthcar profession must examin previous work suggest trust mistrust may differenti impact vaccin intent via vaccin necess concern multigroup structur equat model util test whether vaccin necess concern mediat associ trust provid health inform mistrust provid willing get covid vaccin model found invari across black white respond trust provid trust healthcar inform exert indirect effect intent vaccin necess mistrust provid exert indirect effect vaccin concern unlik previous work form trust influenc vaccin concern find implic futur communic effort healthcar profession health messeng

D000086382;D014612

T129;T121;T116;T067;T047

36,344,952

letrozol induc endometri prepar improv pregnanc outcom frozen blastocyst transfer compar natur cycl retrospect cohort studi letrozol treatment consid effect option endometri prepar frozen embryo transfer patient ovul disord irregular menstruat howev effect letrozol induc endometri prepar remain unclear ovulatori patient furthermor compar studi report pregnanc complic congenit anomali frozen embryo transfer compar natur letrozol assist cycl studi examin whether letrozol induc endometri prepar affect pregnanc outcom perinat outcom congenit anomali singl vitrifi warm blastocyst transfer svbts ovulatori patient compar natur cycl

D011256;D011248

T033;T046

36,344,951

comparison widefield swept sourc optic coher tomographi angiographi ultra widefield fluorescein angiographi evalu lesion retin vein occlus compar widefield swept sourc optic coher tomographi angiographi ss octa ultra widefield fundus fluorescein angiographi uwf fa detect retin vein occlus rvo lesion

D041623;D012170

T060;T047;T046

36,344,950

public prefer regard prioriti set criteria health intervent budget alloc result survey iranian adult prioriti set health direct impact general public payer final consum public prefer must consid present studi aim provid public prefer health intervent alloc criteria optim alloc public health budget iran

D002017

T170;T057

36,344,949

compar genom examin endophyt potenti pantoea agglomeran dapp pg pantoea agglomeran dapp pg isol endophyt knot tumor caus pseudomona savastanoi pv savastanoi dapp pg oliv tree understand plant pathogen endophyt interact genom level whole genom p agglomeran dapp pg sequenc annot complet genom total size bp contain one circular chromosom four larg circular plasmid aim studi identifi genom featur could play potenti role interact p agglomeran dapp pg p savastanoi pv savastanoi dapp pg purpos compar genom analysi genom p agglomeran dapp pg relat pantoea spp carri p agglomeran dapp pg gene cluster synthesi hrp type iii secret system tss type vi secret system tss autoinduc could play import role plant pathogen communiti enhanc knot format oliv tree identifi addit gene cluster biosynthesi two differ antibiot name dapdiamid e antibiot b found region integr conjug element ice observ depth analysi whole genom suggest character p agglomeran dapp pg isol endophyt bacterium biocontrol activ rather plant pathogen

D020636;D031658

T168;T007;T002

36,344,948

preval pattern mutat rasrafmekerkmapk signal pathway colorect cancer north africa review discuss find analyz data examin kras nras braf mutat patient colorect cancer crc north africa compar preval shown popul ii possibl role dietari lifestyl factor crc risk method use electron databas systemat literatur search perform kras nras braf mutat crc patient morocco tunisia algeria lybia result seventeen studi identifi electron search six studi conduct morocco eight tunisia two algeria one libya total crc patient includ morocco tunisia algeria libya overal averag age patient year old patient predomin male mutat rate kras nras braf patient respect broad rang report kras mutat frequenc report north africa countri kras mutat frequenc morocco tunisia algeria libya gd frequent identifi kras exon mutat follow gv gd gc ga gs gr gv gc gr less import differ among north africa countri morocco tunisia higher preval gd mutat kras exon frequent mutat type kras exon ql qe mutat also found kras exon common mutat follow kn ap av

D048493;D015179

T191;T126;T116

36,344,947

lncrna meg promot cisplatin sensit cervic cancer cell regul mir pten axi cervic cancer cc common gynecolog malign worldwid patient perform serious resist chemotherapi long strand non code rna meg report involv regul chemoresist mani solid tumor howev involv cervic adenocarcinoma report

D062085;D002583;D035683

T123;T191;T114

36,344,946

high densiti lipoprotein cholesterol efflux capac patient obstruct sleep apnea relat diseas sever obstruct sleep apnea osa link acceler risk cardiovascular diseas cvd key cvd risk factor present patient suffer osa hypertens inflamm oxid stress dyslipidemia high densiti lipoprotein hdl cholesterol efflux capac cec propos reliabl biomark hdl function present studi aim quantifi biomark patient osa

D002318;D020181

T047

36,344,945

risk analysi grade radiat pneumon base radiotherapi timelin stage iiiiv non small cell lung cancer treat volumetr modul arc therapi retrospect studi radiotherapi import treatment patient stage iiiiv non small cell lung cancer nsclc due high incid radiat pneumon essenti identifi high risk peopl earli possibl present work investig valu applic differ phase data throughout radiotherapi process analyz risk grade radiat pneumon stage iiiiv nsclc furthermor phase data fusion gradual perform radiotherapi timelin develop risk assess model

D002289;D017564;D050397;D008175;D011014

T061;T050;T191;T037;T047

36,344,944

analges effect arthrit chang follow intra articular inject diclofenac etalhyaluron rat knee osteoarthr model diclofenac etalhyaluron df ha recent develop analges conjug diclofenac hyaluron acid analges anti inflammatori effect acut arthriti studi investig analges effect osteoarthr use rat model monoiodoacet mia

D004008;D020370

T121;T047;T109

36,344,942

high risk hpv infect associ hypermethyl gene oropharyng squamous cell carcinoma hpv posit oropharyng squamous cell carcinoma opscc sensit chemo radiat therapi favor surviv outcom compar hpv negat cancer tumor usual relat tobacco alcohol exposur therefor diagnos hpv posit opscc appropri diseas manag crucial suitabl marker avail detect earli malign hpv infect tissu studi attempt find hpv specif epigenet biomark opscc

D009959;D030361;D002294;D009856;D006258

T123;T047;T191;T116

36,344,941

explor util accept faecal immunochem test fit novel intervent improv colorect cancer crc surveil individu lynch syndrom fit lynch studi singl arm prospect multi centr non randomis studi lynch syndrom ls inherit cancer predisposit syndrom defin pathogen variant mismatch repair mmr epcam gene unit kingdom peopl ls advis undergo biennial colonoscopi earli year age mitig high lifetim colorect cancer crc risk though consider addit surveil intervent applic non invas diagnost devic yet longitudin observ ls patient studi examin role annual faecal immunochem test fit alongsid biennial colonoscopi crc surveil peopl ls

D003123;D015179

T047;T191

36,344,940

effect n acetylcystein patient non cystic fibrosi bronchiectasi nincfb studi protocol multicentr doubl blind randomis placebo control trial n acetylcystein nac specif involv airway mucus clearanc antioxid recommend treatment guidelin non cystic fibrosi bronchiectasi ncfb howev littl clinic evid long term efficaci concern qualiti life qol exacerb patient ncfb addit influenc nac airway bacteri colon chronic inflamm oxid stress ncfb also unclear

D001987;D003550

T047

36,344,939

unlock molecular basi wheat straw composit morpholog trait multi locus gwas rapid reduct emiss fossil fuel burn need curb global climat chang biofuel product crop residu contribut reduc energi crisi environment deterior wheat renew sourc biofuel owe low cost high avail residu thus identifi candid gene control trait pivot effici biofuel product six multi locus genom wide associ ml gwas model appli use tetraploid wheat access detect quantit trait nucleotid qtns fifteen trait associ biomass composit

D014908;D055106

T063;T168;T002

36,344,938

covid vaccin hesit short term long term intent among unvaccin young adult mix method approach american year old fulli vaccin covid june grand fork counti north dakota face similar challeng june individu year old age group vaccin focus unvaccin individu studi aim understand way receiv covid vaccin constru use qualit interview studi compar predictor short term vaccin intent ie next month long term vaccin intent ie three year use onlin survey

D033182;D000086382

T047;T067;T041

36,344,937

impact care elder certif ad compet famili physician practic result pan canadian multipl case studi famili physician serv import role care older adult variabl level train comfort navig complex patient popul care elder coe certif ad compet offer colleg famili physician canada recogn famili physician advanc expertis older adult healthcar explor coe train certif impact primari care deliveri older patient includ factor impact group practic

D010821;D005194

T091;T097

36,344,936

physcomitrium paten cad distinct role growth resist biotic stress physcomitrium paten provid evolutionari link green alga vascular plant although genom p paten includ ortholog core lignin biosynthet enzym occurr lignin moss controversi besid littl inform avail lignin enzym moss date exampl cinnamyl alcohol dehydrogenas cad crucial enzym catalyz last step lignin biosynthet pathway suggest ideal way studi evolutionari process investig function cad evolut studi elucid evolutionari role lignin like earli stage land colon

D019068;D017360

T002

36,344,934

predict hiv proteas cleavag site octapeptid sequenc inform use select classifi hybrid descriptor part world especi underdevelop countri acquir immunodefici syndrom aid still remain major caus death disabl unfavor econom outcom necessit intens research develop effect therapeut agent treatment human immunodefici virus hiv infect respons aid peptid cleavag hiv proteas essenti step replic hiv thus correct time predict cleavag site hiv proteas signific speed optim drug discoveri process novel hiv proteas inhibitor work built compar perform select machin learn model predict hiv proteas cleavag site util hybrid octapeptid sequenc inform compris bond composit amino acid binari profil aabp physicochem properti numer descriptor serv input variabl select machin learn algorithm work differ anteced studi explor subject combin octapeptid descriptor method use instead use various subset dataset train test model combin dataset appli way data split use stratifi fold cross valid techniqu alongsid test set evalu model

D015497;D000163;D015658

T005;T047

36,344,933

nomogram predict sever communiti acquir pneumonia develop diabet patient multicent studi diabet patient communiti acquir pneumonia cap increas risk progress sever cap essenti develop predict tool onset diseas earli identif intervent studi aim develop valid clinic featur base nomogram identifi diabet patient cap risk develop sever cap

D017714;D011014;D003920

T047;T050

36,344,932

predict syntax score ii improv ad tempor heart rate chang discharg first outpati visit patient acut myocardi infarct prognost abil tempor chang rest heart rate hr patient acut myocardi infarct ami cardiovascular cv mortal clinic outcom rare examin studi investig predict valu hr use model syntax score ii sxs ii long term prognosi patient ami

D010351;D009203

T058;T047

36,344,931

associ five obes indic cognit perform taiwan biobank particip obes advers influenc central nervous system cognit function howev relationship various obes indic cognit perform remain controversi unclear obes indic relev cognit impair

D056128;D018070

T033;T184;T093

36,344,930

prognost nomogram acut pancreat percutan biliari stent insert patient malign obstruct studi aim develop valid nomogram predict risk pancreat percutan transhepat biliari stent insert ptbs patient malign biliari obstruct mbo

D002779;D010195;D009369

T047;T046;T191

36,344,929

treatment earli borderlin lesion low immunolog risk kidney transplant patient spanish multicent random control parallel group studi protocol train studi subclin inflamm includ borderlin lesion bl common kidney transplant kt even low immunolog risk patient lead interstiti fibrosistubular atrophi ifta worsen renal function graft loss control studi analyz therapeut benefit treat bl renal function graft histolog furthermor studi use bolus steroid may insuffici slow progress lesion klotho transmembran protein produc main kidney antifibrot properti play crucial role senesc inflamm binomi kidney tissu system local inflamm decreas renal tissu express solubl level klotho therefor import determin whether treatment bl prevent decreas klotho level progress ifta loss kidney function

D016030;D007674

T061;T047

36,344,928

sparkec speed align base dna error correct tool recent year huge improv made context sequenc genom data call next generat sequenc ngs howev dna read generat current ngs platform free error affect qualiti downstream analysi although error correct perform preprocess step overcom issu usual requir long comput time analyz larg dataset generat nowaday ngs therefor new softwar capabl scale cluster node high perform great import

D012984;D059014

T063;T090;T073;T059;T170

36,344,927

associ treatment failur hospit receipt neutral monoclon antibodi treatment covid outpati neutral monoclon antibodi mab high effect reduc hospit mortal among earli symptomat covid patient clinic trial real world data resist mab sinc emerg among new variant characterist associ treatment failur mab remain unknown

D000086382

T047;T067

36,344,926

develop novel immun relat lncrna prognost signatur patient hepatocellular carcinoma hepatocellular carcinoma hcc common neoplasm major caus cancer associ death worldwid high mortal rate hcc main attribut widespread preval lack effect treatment immunotherapi promis innov approach revolutionis treatment solid tumour howev owe heterogen complex tumour microenviron hcc effici biomark immunotherapi yet identifi investig role immun relat long non code rnas lncrnas prognost biomark patient hcc cancer genom atlas tcga databas spearman correl univari multivari cox lasso regress analys utilis screen lncrnas associ prognosi four lncrnas filter develop immun associ lncrna prognost signatur tcga train well valid cohort patient hcc categoris low high risk group accord median valu risk score evalu abil prognost model train valid cohort nomogram base risk score stage construct apprais general overal surviv os patient hcc differ immun cell infiltr immun checkpoint inhibitor ici treatment respons gene mutat drug sensit observ two group thus lncrna prognost signatur serv sensit prognost biomark potenti individualis immunotherapi hcc patient

D006528;D062085;D008113

T123;T191;T114

36,344,924

comparison onset time durat action intub condit cisatracurium mgkg young elder patient tracheal intub anesthesia facilit neuromuscular block agent cisatracurium howev limit data exist onset time durat action effect intub condit elder patient year age hypothes elder patient would present longer onset time durat action compar younger adult

D015742;D009466

T121;T109

36,344,923

preval hepat b virus infect gulf cooper council systemat review meta analysi hepat b virus hbv infect global public health problem sinc introduct effect vaccin epidemiolog hbv infect chang aim estim preval hbv infect gulf cooper council gcc region delin variat member countri special sub group time

D006515;D006509

T005;T047

36,344,922

rna sequenc heterorhabd nematod identifi factor involv symbiosi photorhabdus bacteria nematod major group soil inhabit organ heterorhabd nematod insect pathogen nematod live close symbiot associ photorhabdus bacteria heterorhabd photorhabdus pair offer power genet tractabl model studi anim microb symbiosi possibl generat symbiont bacteria free axen stage heterorhabd compar transcriptom symbiot earli adult stage heterorhabd nematod axen earli adult nematod determin nematod gene pathway involv symbiosi photorhabdus bacteria

D020637;D017172

T007;T204

36,344,920

analysi ct mr imag featur brain patient hydrogen sulfid poison base clinic symptom grade retrospect analyz ct mr imag featur brain patient hydrogen sulfid poison base clinic symptom grade investig correl clinic symptom patient prognosi

D006862;D001929

T131;T197;T046;T130

36,344,919

cyclosporin therapi could consid membranoprolif glomerulonephr immunoglobulin deposit case report membranoprolif glomerulonephr mpgn rare glomerulonephr caus nephrot syndrom children often difficult treat typic immunofluoresc find includ strong c stain granular pattern along glomerular capillari wall negat iga stain iga domin mpgn without hypocomplementemia report herein report rare case mpgn hypocomplementemia predomin iga subclass deposit

D015432;D005921

T047

36,344,918

factor associ polypharmaci high risk medic relat problem among older communiti dwell adult european countri longitudin studi polypharmaci defin use five medic simultan medic relat problem extens polypharmaci includ inappropri prescrib poor adher overdosag underdosag inappropri drug select inadequ monitor advers drug effect drug interact polypharmaci high risk medic relat problem among older peopl associ advers health consequ due drug drug interact drug diseas interact advers drug effect studi aim assess factor associ polypharmaci high risk medic relat problem among communiti dwell older peopl netherland greec croatia spain unit kingdom

D019338;D064420

T061;T046;T037

36,344,917

compar studi dexmedetomidin versus fentanyl adjuv bupivacain ultrasound guid transversus abdomini plane block patient undergo radic cystectomi prospect randomis studi transversus abdomini plane tap block benefici pain manag conduct abdomin surgeri

D002045;D020927

T121;T109

36,344,916

individu dynam predict prognost analysi long term allograft surviv kidney transplant predict allograft surviv vital effici transplant success dynam chang patient condit clinic indic may chang longitudin doctor judgment may high variabl necessari establish dynam model precis predict individu risksurviv new allograft

D016030

T061

36,344,915

unveil hotspot genet divers southern itali endang hermann tortois testudo hermanni hotspot intraspecif genet divers repres invalu resourc speci cope environment chang identif increas recogn major goal conserv ecolog research howev even icon endang speci conserv strategi often plan without thorough inform geograph pattern genet variat investig spatial pattern genet variat endang hermann tortois testudo hermanni italian peninsula genotyp individu microsatellit loci aim contribut plan effect conserv strategi

D014426

T014

36,344,914

magnet reson imag parotid gland tumor pictori essay imag parotid gland tumor challeng due wide varieti differenti diagnos malign parotid tumor similar featur benign one slow growth displac instead infiltr neighbor structur malign benign tumor may therefor clinic distinguish correct character parotid tumor ie benign malign determin preoper treatment plan import optim individu surgic plan magnet reson imag mri imag modal choic evalu suspect parotid gland lesion differenti benign malign lesion certain convent mri featur suggest whether mass like benign low grade malign high grade malign ad diffus weight imag advanc mri techniqu like perfus aid distinct morpholog featur seen mri low signal w infiltr chang ill defin margin chang time diffus restrict point malign natur lesion mri use detect local lesion associ find like perineur spread tumor lymph node involv infiltr chang surround tissu pictori essay present select imag varieti benign malign parotid tumor emphas mri featur may use character

D010307

T191

36,344,913

duet snp assist structur variant call phase use oxford nanopor sequenc whole genom sequenc use long read oxford nanopor technolog ont minion sequenc provid cost effect option structur variant sv detect clinic applic despit advantag use long read howev accur sv call phase still challeng

D020641;D000081414

T063;T086

36,344,912

preval cardiometabol risk lifestyl factor young parent evid german birth cohort studi studi show parent signific impact children health cardiometabol risk profil health behavior littl inform preval cardiometabol risk factor lifestyl factor among new parent yet aim studi therefor evalu preval cardiometabol risk factor parent infant germani examin lifestyl health behavior

D003924;D006973

T047

36,344,911

circul season influenza virus differ transmiss zone africa influenza respons million sever case death everi year worldwid develop countri account influenza death children year age paper aim determin dynam influenza virus african transmiss area identifi region season appropri decis make develop region prepared respons strategi

D053118;D053122;D053124;D009981;D007251

T005;T047