PMID
int64 35.7M
36.4M
| Title/Abstract
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36,344,546
|
cdd depend rewir lipid metabol macrophag regul innat immun respons alter cellular metabol underpin macrophag activ yet littl known regard key immunolog molecul regul metabol program macrophag uncov function antigen present molecul cdd control lipid metabol show cdd defici macrophag exhibit metabol reprogram downregul lipid metabol pathway increas exogen lipid import metabol rewir prime macrophag enhanc respons innat signal cdd ko cell show higher signal cytokin secret upon toll like receptor stimul mechanist cdd modul lipid import control intern lipid transport cd block lipid uptak cd restor metabol immun respons macrophag thus data reveal cdd key regul inflammatori metabol circuit macrophag independ function control cell respons
|
D050356;D007113
|
T032;T044
|
36,344,545
|
microbiolog analysi bioremedi bioassay character industri effluent studi aim investig bacteria biodegrad oil pollut oili industri wastewat use bioremedi tool determin character bioremedi bioassay screen bioassay carri use six exogen environment bacteri strain degrad oili pollut indic promis clearanc oili wastewat two strain name enterobact cloaca r pseudomona otiti mcc r could success elimin oil content reason remov organ load result show two promis bacteri candid r r select accord preliminari screen six test bacteria consid effici test paramet highest remov effici remov effici result residu level total dissolv solid tds biochem oxygen demand chemic oxygen demand oil content treat oili wastewat effluent mgl respect result within safe discharg limit except tds henc bioremedi assay carri use mix cultur sinc effici strain degrad test paramet
|
D062065;D014874
|
T131;T083;T069
|
36,344,544
|
analysi match primari recurr brca mutat associ tumor identifi recurr specif driver recurr major caus death among brca mutat carrier breast brca ovarian cancer ovca herein perform multi omic sequenc pair primari recurr brca ovca brca mutat carrier identifi potenti recurr specif driver parp amplif identifi recurr fals discoveri rate q parp signific overexpress across primari brca recurr brca ovca independ amplif status rna sequenc analysi find two brca isoform brca long brca short respect predict sensit insensit nonsens mediat decay brca short express frequent recurr associ reduc overal surviv breast cancer vs month hazard ratio loss heterozygos loh status discord patient primari recurr tumor switch loh lack loh found studi reveal multipl potenti driver recurr diseas brca mutat associ cancer improv understand tumor evolut suggest potenti biomark
|
D010051;D001943
|
T191
|
36,344,543
|
sharp dose profil high precis proton therapi use strong focus proton beam main object radiotherapi exploit curat potenti ioniz radiat inflict minim radiat induc damag healthi tissu sensit organ proton beam therapi develop irradi tumor higher precis dose conform compar convent x ray irradi dose conform treatment modal may improv narrow proton beam use still limit multipl coulomb scatter proton tissu primari aim work develop techniqu produc narrow proton beam investig result dose profil introduc assess three differ proton beam shape techniqu metal collim mev focus convent mev focus high energi mev shoot proton beam focus govern initi valu twiss paramet formula see text formula see text implement magnet particl acceler optic dose distribut water calcul mont carlo simul use geant evalu target surfac dose ratio tsdr addit transvers beam size formula see text target target defin locat bragg peak focal point differ techniqu show great differ dose profil focus gave pronounc higher relat target dose effici use primari proton metal collim radii formula see text gave low tsdrs formula see text larg formula see text formula see text contrast focus beam convent formula see text energi produc high tsdr formula see text similar formula see text collim beam high energi focus beam abl produc tsdrs formula see text formula see text around mm studi appear attract implement magnet focus proton beam radiotherapi small lesion tumor close vicin healthi organ risk also lead paradigm chang spatial fraction radiotherapi magnet focus would facilit flash irradi due low loss primari proton
|
D061766;D011851
|
T061;T070
|
36,344,542
|
transplacent transfer total immunoglobulin g antibodi plasmodium falciparum antigen th week gestat term full term newborn antibodi ab repertoir level similar mother help protect environment pathogen unfortun preterm babi especi born week reduc level protect antibodi africa antibodi plasmodium falciparum import protect malaria studi investig transfer total igg antibodi p falciparum antigen tetanus toxoid week term pair matern cord sampl preterm week term deliveri use transfer effici express ratio ab level cord matern plasma cmr week cmr rang differ antigen rate transfer similar antigen week result median cmr term babi mother hypergammaglobulinemia normal igg level similar amount igg support data satur neonat fc receptor occur mg iggml thus babi born prior week africa like reduc ab level antigen sinc igg transfer fc mediat differ exist cmr among antigen warrant investig
|
D010963;D016778
|
T047;T204
|
36,344,540
|
mortal among hospit covid patient surg sar cov alpha b delta b variant aim studi evalu death proport death risk covid hospit patient time differ surg covid multi center observ studi conduct march octob includ alpha delta sar cov surg occur april august tehran respect risk covid death compar differ month admiss total patient covid die admit hospit tehran provinc compar patient admit march higher risk covid death observ among patient admit hospit juli hr ci august hr ci septemb hr ci octob hr ci icu death proport ci alpha surg increas signific ci delta surg risk covid death signific higher delta surg compar alpha surg hr ci delta surg associ higher risk death compar alpha surg high number hospit shortag hospit bed icu space medic suppli poor nutrit status hospit patient lack intensivist physician special nurs icu factor contribut high mortal rate delta surg iran
|
D000086402;D000086382
|
T005;T067;T047
|
36,344,539
|
diagnost yield candid gene pitfal genet studi intellectu disabl middl eastern famili global development delayintellectu disabl id term use describ various disord caus abnorm brain develop character impair cognit communic behavior motor skill past year whole exom sequenc wes proven power robust scalabl approach candid gene discoveri consanguin popul studi recruit patient affect id middl eastern famili whole exom sequenc complet individu averag age wes complet year pathogen like pathogen variant detect famili variant uncertain signific seen famili candid gene possibl associ id detect total number affect individu gene novel previous report singl famili caus strike differ phenotyp differ mode inherit gene includ aatk apg camsap ccdcb cntrob dnah dnajb drg dtnbp edrf eefd exoc exosc farsb fbxo filip inppa prx prdm ptrhd scna scyl smg supvl tacc thumpd xpr zfyve year studi gene match databas sever gene confirm causat id conclus understand caus id help understand biolog mechan provid precis counsel affect famili aid primari prevent
|
D008607;D044783
|
T116;T048
|
36,344,537
|
first report glyphos resist downi brome bromus tectorum l canada glyphos use herbicid worldwid import sourc econom weed control glyphos resist crop conserv tillag system among use downi brome bromus tectorum l otherwis known cheatgrass high invas winter annual grass weed crop system pastureland natur ruder area western north america downi brome popul remain uncontrol follow four applic glyphos glyphos resist canola brassica napus l field locat taber counti alberta canada individu subsequ generat popul surviv glyphos treatment typic field rate g ae ha dose respons bioassay putat glyphos resist popul exhibit fold fold fold fold resist glyphos base plant surviv visibl control biomass fresh weight dri weight respect compar two suscept popul day treatment estim glyphos rate control popul rang g ae ha well common usag rate downi brome popul repres first glyphos resist grass weed confirm canada second weed speci exhibit glyphos resist canadian prairi region
|
D006540;D029688
|
T131;T168;T002
|
36,344,536
|
multi marker integr analysi reveal benefit risk bariatr surgeri bariatr surgeri bs effect intervent sever obes associ comorbid although sever studi address clinic metabol effect bs integr analysi complex bodi respons surgeri still lack conduct longitudin data studi patient sever obes test month restrict bs one hundr blood biomark includ clinic oxid stress metabol marker peptid mediat red blood cell membran lipid use synthet data driven model base princip compon correl analys provid evid besid earli well known glucos metabol weight loss associ benefici effect bs tardiv weight independ increas hepat cholesterol metabol occur associ potenti detriment inflammatori metabol effect canon correl analysi indic oxid stress predict featur bs induc chang glucos lipid metabol result show power multi level correl analysi uncov network biolog pathway affect bs approach highlight potenti health risk restrict bs disregard current practic use weight loss surrog bs success
|
D009767;D050110
|
T061;T047
|
36,344,535
|
photosynthet modul diurnal cycl unicellular diazotroph cyanobacterium grown nitrogen replet nitrogen fix condit cyanobacteria oxygen photosynthet organ fix nitrogen diazotroph cyanobacteria regul photosynthesi diurnal cycl hypothes link nitrogen fixat involv protein isoform psba amount bioavail nitrogen major impact product aqueous environ contrast low nitrogen fix n condit littl data photosynthet regul nitrogen replet n condit avail compar regul photosynthesi n n condit diurnal cycl wild type psba delet strain unicellular diazotroph cyanobacterium cyanothec sp atcc observ common chang light harvest photosynthet electron transport dark n n condit found modif occur diazotroph non diazotroph cyanobacteria nitrogen avail increas psii titer cell transit dark light promot growth n condit delet psba modifi charg recombin dark regul psii titer dark light transit conclud dark impact acceptor side modif psii photosynthet electron transport cyanobacteria independ nitrogen fix status presenc psba
|
D046889;D000458
|
T007
|
36,344,534
|
wave like pattern paramet space interpret evid macroscop effect result quantum quantum like process brain data eight numeros estim experi reliabl exhibit wave like pattern plot standard deviat respons time along abstract paramet magnitud error numeros estim explan phenomenon propos term analog respons time error magnitud one hand energi posit quantum particl construct use argument overlap mathemat apparatus describ hopfield type neural network quantum system establish research altern explan present within tradit explanatori framework oscil due neural fire involv hypothet mechan convert oscil pattern time oscil pattern space abstract paramet magnitud error numeros estim viabil propos causal influenc propag microscal quantum phenomena macroscal human behavior need first type explan exemplifi phenomenon magnetorecept speci bird alleg quantum natur
|
D001921;D016571
|
T023;T170
|
36,344,533
|
activ site loop toggl conform control antibiot hydrolysi inhibit potenc ctx lactamas drug resist enzym lactamas inactiv lactam antibiot lead drug resist consequ inhibitor lactamas combat resist lactamas inhibitori protein blip natur occur inhibitor widespread ctx ctx lactamas sequenc ident studi show blip weak inhibit ctx potent inhibit ctx structur blipctx complex reveal bind associ conform chang activ site loop lactamas surpris loop structur complex similar drug resist variant ns ctx hypothes pre establish favor loop conform ns mutant would facilit bind ns substitut result fold increas blip inhibit potenc ctx ctx respect thus indic activ site loop lactamas toggl conform control antibiot hydrolysi inhibitor suscept find highlight role access activ site conform control enzym activ inhibitor suscept well influenc mutat select stabil discret conform
|
D000900;D004926
|
T121;T007;T195
|
36,344,532
|
atrial fibril predict combin ecg marker cmr radiom atrial fibril af common cardiac arrhythmia associ higher risk import advers health outcom stroke death af link distinct electro anatom alter main tool af diagnosi electrocardiogram ecg howev ecg record singl time point may detect individu paroxysm af studi develop machin learn model discrimin preval af use combin imag deriv radiom phenotyp ecg featur thus character phenotyp preval af term ecg imag alter moreov explor sex differenti remodel build sex specif model integr model includ radiom ecg togeth result better perform ecg alon particular women ecg lower perform women men auc vs p ad radiom featur accuraci model abl improv signific sensit also increas consider women ad radiom vs p higher detect af event find provid novel insight af relat electro anatom remodel variat sex integr radiom ecg model also present potenti novel approach earlier detect af
|
D001281;D020521
|
T047;T046
|
36,344,531
|
comput simul target predict studi solubl optim decitabin supercrit solvent comput analysi drug solubl carri use machin learn approach solubl decitabin model drug supercrit co studi function pressur temperatur assess feasibl product nanomedicin enhanc solubl data collect solubl optim decitabin temperatur k pressur bar use input machin learn model dataset data point two input p appli optim solubl output solubl decitabin mole fraction solubl solvent develop model three model includ kernel ridg regress krr decis tree regress dtr gaussian process gpr use first time novel model model optim use hyper paramet tune assess use standard metric show r score krr dtr gpr equal also mae metric show e e e error rate order metric mape krr error rate e dtr show error rate equal e gpr best mode illustr e final analysi use best model gpr reveal increas input result increas solubl decitabin optim valu p e e
|
D000069550
|
T066
|
36,344,528
|
phosphat limit intensifi negat effect ocean acidif global import nitrogen fix cyanobacterium growth promin nitrogen fix cyanobacterium trichodesmium often limit phosphorus avail ocean nitrogen fixat phosphorus limit trichodesmium may respond ocean acidif remain poor understood use phosphat limit chemostat experi show acidif enhanc phosphorus demand decreas phosphorus specif nitrogen fixat rate trichodesmium increas phosphorus requir attribut primarili elev cellular polyphosph content like maintain cytosol ph homeostasi respons acidif alongsid accumul polyphosph decreas nadp h nad h ratio impair chlorophyl synthesi energi product observ acidifi condit consequ negat effect acidif amplifi compar demonstr previous phosphorus suffici estim potenti implic find use output communiti earth system model predict acidif dissolv inorgan organ phosphorus stress could synergist caus appreci decreas global trichodesmium nitrogen fixat
|
D000072359;D000458
|
T007
|
36,344,527
|
neuroprotect action klotho lps activ glia condit medium primari neuron cultur klotho anti age protein overexpress extend life span human mice anti inflammatori protect action renal cell inhibit nf b activ product inflammatori cytokin respons tnf furthermor studi shown neuroprotect effect klotho neuroinflamm differ condit age anim model neurodegen diseas ischem brain injuri work aim evalu effect klotho protein primari glial cell cultur proinflammatori challeng lps could interfer neuron health cortic mix glial cell purifi astrocyt pretreat klotho stimul lps follow tnf il il ifn level nf b activ analysi condit medium cortic mix glia cultur treat lps glia condit medium gcm use induc neuron death primari cortic neuron cultur evalu gcm kl medium glia cultur pretreat klotho follow lps stimul gcm lps presenc kl revers effect lps treatment glial cell induc increas proinflammatori mediat tnf il il ifn activ astrocyt nf b gcm treat cortic neuron cultur induc concentr depend neuron death pretreat klotho decreas tnf il product revert nf b activ decreas neuron death induc gcm addit kl incub togeth gcm lps complet revert neuron toxic induc low concentr gcm lps data suggest anti inflammatori neuroprotect effect klotho protein cns work demonstr therapeut potenti klotho patholog process involv neuroinflammatori compon
|
D016328;D018696
|
T129;T121;T169;T116
|
36,344,526
|
mitochondri membran protein vps orchestr select remov mtdna understand mechan govern select turnov mutat bear mtdna fundament design therapeut strategi mtdna diseas show specif mtdna damag lead exacerb mtdna turnov independ canon macroautophagi reli lysosom function atg use proxim label twinkl nucleoid marker demonstr mtdna damag induc membran remodel endosom recruit close proxim mitochondri nucleoid sub compart target mitochondri nucleoid control atad samm axi disrupt upon mtdna damag samm act gatekeep influenc bak cluster control nucleoid releas facilit transfer endosom vps mediat matur earli endosom late autophagi vesicl degrad occur addit use mous model mtdna alter caus impair muscl regener show stimul lysosom activ rapamycin select remov mtdna delet without affect mtdna copi number amelior mitochondri dysfunct taken togeth data demonstr upon mtdna damag mitochondri nucleoid elimin outsid mitochondri network endosom mitophagi pathway result unveil molecular player complex mechan multipl potenti benefit understand mtdna relat diseas inherit acquir due normal age
|
D004272;D051336
|
T026;T123;T114
|
36,344,525
|
samhd deacetyl sirt promot dna end resect facilit dna bind doubl strand break steril alpha motif hd domain contain protein samhd dntpase independ function promot dna end resect facilit dna doubl strand break dsb repair homolog recombin hr howev known upstream signal event govern activ show samhd deacetyl sirt sirtuin deacetylas facilit bind ssdna dsbs promot dna end resect hr sirt complex deacetyl samhd conserv lysin k specif respons dsbs k deacetyl sirt promot dna end resect hr samhd tetramer dntpase activ mechanist k deacetyl sirt promot samhd recruit dsbs bind ssdna dsbs turn facilit ctip ssdna bind lead promot genom integr find defin mechan govern dntpase independ resect function samhd sirt deacetyl promot hr genom stabil
|
D056564;D053903
|
T049;T126;T116
|
36,344,524
|
hippocamp converg anticipatori midbrain activ promot subsequ memori format hippocampus focus memori research sinc hm surgeri abolish abil form new memori yet mechanist role memori remain debat identifi candid memori mechan anticipatori hippocamp converg state observ await valuabl inform predict subsequ learn fmri particip view trivia question elicit high low curios follow second later answer reason encod success requir confluenc condit hippocamp state conduc memori format converg state space operation converg neural state quantifi typic multivoxel pattern medial tempor lobe anticip encod trivia answer found typic anticipatori hippocamp pattern increas high curios crucial anticipatori hippocamp pattern typic increas dopaminerg midbrain activ uniqu account associ midbrain activ subsequ recal propos hippocamp converg state may complet cascad motiv midbrain activ memori enhanc may general predictor memori format
|
D006624;D008636
|
T026;T023
|
36,344,522
|
discern asthma endotyp comorbid map asthma heterogen complex syndrom identifi asthma endotyp challeng hypothes distinct endotyp asthma aris dispar genet variat life time environment exposur background diseas comorbid pattern serv surrog genet exposur variat comput discov distinct comorbid diseas pattern among individu asthma asthma comorbid subgroup use diagnosi record us resid identifi subgroup much smaller uk biobank gwass discern asthma risk loci individu within subgroup subgroup combin reveal independ risk loci replic multi ancestri meta analysi across differ ethnic subsampl uk biobank us biovu biobank japan fourteen loci confer asthma risk multipl subgroup subgroup combin import anoth six loci confer asthma risk one subgroup strength associ asthma health relat phenotyp also vari dramat across subgroup work reveal subpopul asthma patient distinguish comorbid pattern asthma risk loci gene express health relat phenotyp reveal differ asthma endotyp
|
D001249
|
T047
|
36,344,521
|
regulom base character drug activ across human diseasom drug expect recov cell system away impair state normalci diseas treatment howev understand gene regulatori machineri under drug activ diseas pathogenesi far complet perform larg scale regulom analysi various diseas term gene regulatori machineri transcriptom signatur convert regulom signatur transcript factor integr public avail chip seq data regulom base correl diseas approv drug much clearer transcriptom base correl exampl invers correl observ cancer wherea posit correl observ immun system diseas demonstr use regulom base drug discoveri method term accuraci applic predict new drug nonsmal cell lung cancer valid anticanc activ vitro propos method use understand diseas diseas relationship drug discoveri
|
D002289;D008175
|
T191
|
36,344,520
|
hippocamp astrocyt modul anxieti like behavior astrocyt affect anim behavior regul tripartit synapt transmiss yet influenc affect behavior remain larg unclear show hippocamp astrocyt calcium activ reflect mous affect state virtual elev plus maze test use two photon calcium imag vivo furthermor optogenet hippocamp astrocyt activ elev intracellular calcium induc anxiolyt behavior astrocyt specif channelrhodopsin chr transgen mice hgfap chr mice under mechan found atp releas activ hippocamp astrocyt increas excitatori synapt transmiss dentat gyrus dg granul cell exert anxiolyt effect data uncov role hippocamp astrocyt modul mice anxieti like behavior regul atp mediat synapt homeostasi hippocamp dg granul cell thus manipul hippocamp astrocyt activ therapeut strategi treat anxieti
|
D001253;D002118
|
T123;T196;T121;T025
|
36,344,519
|
function graphen grid various charg singl particl cryo em major hurdl singl particl cryo em structur determin lie specimen prepar impair air water interfac awi preferenti particl orient problem work develop function graphen grid various charg via dediazoni reaction cryo em specimen prepar graphen grid paraffin assist fabric appear less contamin compar produc polym transfer method appli onto three differ type macromolecul demonstr high yield charg graphen grid bring macromolecul away awi enabl adjust particl orient distribut robust singl particl cryo em structur determin
|
D006108
|
T196;T109
|
36,344,518
|
larg scale dataset reveal taxonom function specif wild bee communiti urban habitat western europ wild bee declin main due expans urban habitat led land use chang effect urban wild bee communiti still unclear shown contrast report speci function divers urban habitat address current controversi built larg dataset merg survey carri countri western europ past decad test whether urban influenc local wild bee taxonom function communiti composit survey encompass rang urban level quantifi use two complementari metric proport impervi surfac human popul densiti urban expans measur proport impervi surfac human popul densiti signific negat correl wild bee communiti speci rich taxonom dissimilar bee communiti independ urban metric howev occurr rate function trait reveal signific differ light high urban communiti urban metric higher human popul densiti probabl occurr ground nester generalist small speci increas higher soil seal probabl occurr ground nester generalist social bee increas well overal result base larg european dataset suggest urban negat impact wild bee divers identifi trait favor urban environ show sever wild bee speci thrive citi
|
D014507;D017753
|
T068;T083;T070;T082
|
36,344,516
|
comparison lithium level suicid non suicid fatal cross section studi ecolog studi suggest protect effect micro dose lithium drink water suicid howev associ bodi lithium level suicid unknown aim compar bodi lithium level suicid non suicid fatal cross section studi includ suicid non suicid examin dissect tokyo medic examin offic march june aqueous humor lithium concentr measur twice use induct coupl plasma mass spectrometri analysi covari ancova use compar lithium concentr suicid non suicid mix effect model conduct account lithium concentr data aqueous humor lithium concentr chang death formula see text se ci p cohen aqueous humor lithium concentr lower suicid mean gl varianc non suicid mean gl formula see text se ci p cohen ancova show death suicid signific associ lower lithium concentr f p effect size larg p random intercept model show signific effect suicid aqueous humor lithium concentr b se ci p result studi demonstr even micro dose lithium associ suicid death clinic studi warrant examin effect micro dose lithium suicid prevent
|
D008094;D060766
|
T121;T196;T167
|
36,344,514
|
interplay dopamin metabol abnorm mitochondri defect pathogenesi schizophrenia dopamin da major monoamin neurotransmitt brain essenti role higher function brain malfunct dopaminerg signal implic various mental disord addict attent deficithyperact disord huntington diseas parkinson diseas pd schizophrenia pathogenesi pd schizophrenia involv interplay mitochondri defect da metabol abnorm articl focus issu schizophrenia start introduct metabol behavior action physiolog da follow review evid malfunct dopaminerg signal patient schizophrenia provid overview multipl facet mitochondri physiolog summar mitochondri defect report clinic studi schizophrenia patient final discuss interplay da metabol abnorm mitochondri defect outlin clinic studi show effect combin therapi antipsychot antioxid treat patient schizophrenia updat integr line inform may advanc understand etiolog pathogenesi phenomenolog treatment schizophrenia
|
D012559;D014150;D010300
|
T047;T121;T039;T048
|
36,344,512
|
connect multipl microenviron proteom uncov biolog head neck cancer poor prognosi head neck cancer hnc associ metastasi within lymph node lns herein proteom multisit sampl hnc patient cohort includ primari match ln negat posit tissu saliva blood cell reveal insight biolog potenti metastasi biomark may assist clinic decis make protein profil strict associ immun modul across dataset provid basi investig immun marker associ metastasi proteom ln metastat cell recapitul proteom primari tumor site convers ln microenviron proteom highlight candid prognost marker integr priorit peptid protein transcript level machin learn model identifi nodal metastasi signatur blood saliva present proteom character wire multipl site hnc thus provid promis basi understand tumor biolog identifi metastasi associ signatur
|
D020543;D006258
|
T123;T191;T116
|
36,344,511
|
sister chromatid exchang induc perturb replic form independ brca brca rad sister chromatid exchang sces product joint dna molecul resolut consid form homolog recombin hr inde sce induct upon irradi requir canon hr factor brca brca rad contrast replic block agent includ parp inhibitor induc sces independ brca brca rad parp inhibitor induc sces enrich difficult replic genom region includ common fragil site cfss parp inhibitor induc replic lesion transmit mitosi suggest sces origin mitot process replic dna proteom analysi reveal mitot recruit dna polymeras theta polq synthet dna end polq inactiv result reduc sce number sever chromosom fragment upon parp inhibit hr defici cell accord analysi cfss cancer genom reveal frequent allel delet flank signatur polq mediat repair combin show parp inhibit generat replic dna process sces mitosi independ canon hr factor
|
D012854;D000067856
|
T045;T121
|
36,344,510
|
milk protein feed restrict signatur indic metabol adapt dairi cow milk product dairi cow affect numer factor includ diet feed restrict known littl impact milk total protein content effect fine protein composit still poor document object studi describ effect two feed restrict trial differ intens milk protein composit holstein cow one restrict trial high intens h mid lactat holstein cow second moder intens peak lactat holstein cow feed restrict decreas milk protein yield casein trial six major milk protein h trial decreas yield lead lower concentr casein h trial milk proteom analyz milk sampl affect function restrict intens among protein identifi eight vari trial h trial ontolog analys reveal implic carbohydr lipid protein metabol well immun system protein reflect adapt anim mammari gland physiolog feed restrict constitut signatur chang
|
D008894;D007774
|
T123;T116;T042
|
36,344,508
|
forecast individu progress trajectori huntington diseas enabl power clinic trial variabl neurodegen diseas progress pose great challeng evalu potenti treatment identifi person experi signific progress short term key implement trial smaller sampl size appli diseas cours map forecast biomark progress individu carrier patholog cag repeat expans respons huntington diseas use data two longitudin studi track hd track synchron tempor progress clinic imag biomark particip huntington diseas use result hd cours map forecast clinic endpoint baselin data particip enrol hd extern valid cohort use forecast select particip risk progress comput power trial enrich popul hd cours map forecast biomark year baselin measur maximum mean absolut error point total motor score total function capac allow reduc sampl size trial includ particip higher risk progress ensur homogen group particip
|
D006816;D019636
|
T047
|
36,344,507
|
robust replic initi coupl homeostat mechan bacterium escherichia coli initi replic per cell cycl precis volum per origin add averag constant volum success initi event independ initi size yet molecular model explain observ lack experi indic e coli control replic initi via titrat activ initi protein dnaa studi mathemat model two mechan interact generat robust replic initi cycl first show mechan sole base titrat generat stabl replic cycl low growth rate inevit caus prematur reiniti event higher growth rate regim dnaa activ switch becom essenti stabl replic initi convers activ switch alon yield robust rhythm high growth rate titrat strong enhanc stabil switch low growth rate analysi thus predict mechan togeth drive robust replic cycl growth rate addit reveal origin densiti sensor yield adder correl
|
D004926;D029968
|
T007;T116
|
36,344,505
|
pa msha induc inflam tumor microenviron sensit tumor anti pd therapi low respons rate immun checkpoint inhibitor ici therapi imped clinic use report previous inflam tumor microenviron tme direct correl patient respons immun checkpoint blockad icb thus restor cytotox effect immun cell tme promis way improv efficaci icb overcom primari resist immunotherapi effect pseudomona aeruginosa mannos sensit hemagglutinin pa msha facilit cell activ determin vitro vivo subset immun cell analyz flow cytometri proteom carri comprehens analyz discrimin cellular kinas transcript factor combin efficaci pa msha pd therapi studi vivo studi demonstr pa msha clinic use immun adjuv effect induc anti tumor immun respons suppress growth non small cell lung cancer nsclc cell pa msha show great potenti sensit refractori cold tumor immunotherapi effect enhanc macrophag polar induc cell activ vivo combin pd pa msha suppress tumor growth prolong surviv time allograft model mice result indic pa msha potent agent stimul immun cell infiltr tme consequ induc inflamm tumor combin pa msha pd potenti strategi enhanc clinic respons rate ici therapi
|
D002289;D008175
|
T191
|
36,344,504
|
structur iscb rna ribonucleoprotein complex like ancestor crispr cas transposon encod iscb famili protein rna guid nucleas omega oblig mobil element guid activ system like ancestor rna guid nucleas cas type ii crispr cas adapt immun system iscb associ cognat rna form ribonucleoprotein complex cleav doubl strand dna target complementari rna guid segment although iscb share ruvc hnh endonucleas domain cas much smaller cas main due lack helic nucleic acid recognit lobe report cryo electron microscopi structur iscb protein human gut metagenom ogeuiscb complex cognat rna target dna resolut high resolut structur reveal detail architectur iscb rna ribonucleoprotein complex show small iscb protein assembl rna mediat rna guid dna cleavag larg rna scaffold structur function compens recognit lobe cas particip recognit guid rna target dna heteroduplex find provid insight mechan programm dna cleavag iscb rna complex evolut type ii crispr cas effector complex
|
D064113;D017394
|
T123;T040;T114
|
36,344,503
|
specialist multidisciplinari input maximis rare diseas diagnos whole genom sequenc diagnost whole genom sequenc wgs increas use rare diseas howev standard semi autom wgs analysi may overlook diagnos complex disord show specialist multidisciplinari analysi wgs follow initi primari find npf report improv diagnost rate alter manag undertook wgs adult diagnost challeng primari mitochondri diseas phenotyp npf case review genom medicin team thus enabl bespok informat approach co ordin phenotyp valid function work enhanc diagnost rate manag implic new diagnos detect strong candid diseas caus variant patient approach present standardis model care support mainstream clinician enhanc diagnost equiti complex disord therebi facilit access potenti benefit genom healthcar research made possibl access data find generat genom project http wwwgenomicsenglandcouk
|
D035583;D016678
|
T047;T028
|
36,344,502
|
sirt promot viabil invas metastasi osteosarcoma cell inhibit degrad snail osteosarcoma os high metastat usual lead poor outcom epitheli mesenchym transit emt report critic event metastasi sirt exert dual function mani differ tumor howev under molecular mechan sirt osteosarcoma cell metastasi question whether sirt regul emt fulli explor studi confirm sirt high express human osteosarcoma mg sao cell line viabil migrat invas osteosarcoma cell inhibit knockdown sirt enhanc overexpress sirt moreov sirt posit regul emt upregul protein level mesenchym marker n cadherin vimentin level mmp mmp xenograft mous model show sirt knockdown osteosarcoma cell led reduc tumor growth decreas express mesenchym marker impair lung liver metastasi vivo furthermor show sirt interact upregul protein level emt associ transcript factor snail sirt inhibit snail degrad via deacetylas activ knockdown snail abrog promot effect sirt migrat invas osteosarcoma cell conclus sirt play crucial role osteosarcoma metastasi inhibit snail degrad may serv novel therapeut target manag osteosarcoma
|
D001859;D012516
|
T191
|
36,344,501
|
social interact lead motil induc phase separ fire ant collect fire ant form activ matter ant use intern metabol self propel absenc align interact theori simul predict activ matter spatial depend motil undergo motil induc phase separ howev far experi motil effect drive process come either crowd extern paramet though fire ant social insect communic cooper nontrivi way show effect interact also understood within framework motil induc phase separ context slow ant approach result effect attract lead space fill cluster eventu format dynam heterogen result illustr motil induc phase separ provid unifi framework ration behavior wide varieti activ matter system
|
D001000;D001180
|
T123;T121;T131;T204
|
36,344,500
|
dna barcod reveal ongo immunoedit clonal cancer popul metastat progress immunotherapi respons cancer evad immun system process cancer immunoedit immun checkpoint inhibitor effect reactiv tumour immun cancer type mani solid cancer includ breast cancer remain larg non respons understand non respons cancer evad immun whether occur clonal level improv immunotherapeut design use dna barcod track murin mammari cancer cell clone immunoedit determin clonal transcript profil allow immun evas follow anti pd plus anti ctla immunotherapi clonal divers signific restrict immunotherapi treatment primari tumour metastas demonstr select pre exist breast cancer cell popul ongo immunoedit metastasi treatment immunotherapi resist clone express common gene signatur associ poor surviv basal like breast cancer patient cohort least one gene exist small molecul potenti use improv immunotherapi respons
|
D058893;D001943
|
T062;T087;T191
|
36,344,498
|
neural circuit dynam drug context associ learn mous hippocampus environment context associ previous drug consumpt potent trigger drug relaps howev mechan neural represent context modifi incorpor inform associ drug abus remain unknown use longitudin calcium imag freeli behav mice find unlik associ learn natur reward drug context associ psychostimul opioid encod specif subset hippocamp neuron drug condit neuron weaken spatial code non drug pair context result orthogon represent drug versus non drug context predict drug seek behavior furthermor neuron select base drug spatial experi exclus tune anim allocentr posit togeth work reveal drug abus alter hippocamp circuit encod drug context associ point possibl target drug associ memori hippocampus
|
D003214;D006624
|
T026;T023;T041
|
36,344,497
|
mechan marker novel noninvas eeg proxi marker neural excit inhibit system human brain function product balanc excitatori inhibitori ei brain activ variat regul activ thought give rise normal variat human trait disrupt thought potenti underli spectrum neuropsychiatr condit eg autism schizophrenia down syndrom intellectu disabl hypothes relat ei dysfunct potenti provid cross diagnost explan combin genet neurolog evid exist within psychiatr condit howev hypothesi difficult test lack specif ei dysfunct could pertain level neural system neurotransmitt singl neuronsreceptor local network neuron global brain balanc research defin level examin ei function lack valid method assess ei function neural level human result possibl reliabl robust test ei hypothesi psychiatr disord larg cohort longitudin patient studi current avail vivo marker ei human either carri signific risk eg deep brain electrod record use positron emiss tomographi pet radioact tracer andor high restrict eg limit spatial extent transcrani magnet stimul tms magnet reson spectroscopi mrs recent rang novel electroencephalographi eeg featur describ could serv proxi marker ei given level infer thus perspect review survey theori experiment evid under novel eeg marker biolog underpin specif neural level cheap record scalabl proxi marker may offer clinic util identifi subgroup within diagnost categori thus direct tailor sub group therefor treatment strategi howev argu studi clinic popul prematur maxim potenti prospect eeg marker first need understand link under ei mechan measur techniqu
|
D004569;D012559
|
T060;T034;T048
|
36,344,495
|
lncrna sftap promot cervic cancer progress interact ptbp facilit tpm mrna degrad long non code rnas lncrnas play key role cancer develop progress howev biolog function clinic signific lncrnas cervic cancer remain elus studi explor function mechan lncrna surfact associ sftap cervic cancer first identifi sftap analyz rna sequenc data cervic cancer previous studi cancer genom atlas tcga verifi sftap express qrt pcr cell prolifer migrat capac sftap assess use cck coloni format transwel wound heal assay rna pull rna immunoprecipit rip rna stabil western blot assay use reveal potenti mechan athym nude mice use evalu tumorigen metastasi vivo sftap upregul cervic tumor tissu high express associ poor prognosi biolog knockdown sftap inhibit prolifer migrat invas cervic cancer cell vitro well tumorigenesi metastasi vivo mechanist sftap shown interact polypyrimidin tract bind protein ptbp regul stabil tropomyosin tpm mrna therebi result malign cell phenotyp tpm knockdown could attenu suppress cell progress induc either sftap ptbp knockdown find demonstr sftap promot tumor progress mediat degrad tpm mrna interact ptbp protein provid potenti therapeut strategi target sftap ptbp tpm axi cervic cancer
|
D062085;D002583
|
T123;T191;T114
|
36,344,492
|
circfoxo protect osteoarthr target parent gene foxo activ pikakt mediat autophagi osteoarthr oa degen joint disord caus pain function disabl emerg evid reveal circular rnas circrna play essenti role oa progress develop studi aim investig role novel circrna factor circfoxo progress oa elucid under molecular mechan function circfoxo oa interact circfoxo downstream mrna target forkhead box foxo evalu western blot wb immunofluoresc rna immunoprecipit revers transcript quantit pcr rt qpcr fluoresc situ hybrid fish upregul circfoxo autophag flux detect vivo vitro wb transmiss electron microscopi tem immunohistochemistri ihc mous model oa also use confirm role circfoxo oa pathogenesi vivo decreas express circfoxo oa cartilag tissu direct associ excess apoptosi imbal anabol catabol factor extracellular matrix ecm mechanist circfoxo function cartilag target parent gene foxo activ autophagi intra articular inject lentivirus circfoxo allevi oa mous model conclus result reveal key role play circfoxo oa progress circfoxo overexpress may allevi apoptosi chondrocyt promot anabol ecm via activ foxo autophagi provid potenti effect novel therapeut strategi oa
|
D010003;D035683
|
T123;T047;T114
|
36,344,491
|
splice factor srsf repress translat p cipwaf mrna serinearginin rich splice factor srsf rna bind protein often regul gene express splice level although role srsf mrna splice nucleus well known splice independ role outsid nucleus poor understood found srsf exert translat control p mrna deplet srsf induc cellular senesc increas express p independ p consist express pattern srsf p mrna tcga databas srsf knockdown increas p mrna level translat effici well srsf physic associ utr region p mrna translat initi factor eifa studi propos model srsf regul translat interact eifa utr region p mrna also found srsf local cytoplasm rna granul along eifa may assist translat repress therein thus result provid new mode regul p express crucial regul cell cycl senesc occur translat level involv srsf
|
D016601;D012326
|
T045;T123;T116
|
36,344,490
|
egfr tyrosin kinas activ rab gtpase coordin egfr traffick regul macrophag activ sepsi egfr phosphoryl requir tlr mediat macrophag activ sepsi howev whether intracellular egfr transport endotoxemia larg unknown show lps promot high level cell surfac express egfr macrophag two differ transport mechan one hand rab requir eea mediat membran transloc egfr golgi hand egfr phosphoryl prevent endocytosi kinas activ depend manner erlotinib egfr tyrosin kinas inhibitor signific reduc membran egfr express lps activ macrophag mechanist upon lps induc tlregfr phosphoryl mapk phosphoryl raba impair membran receptor late endocytosi maintain egfr membran local though block lysosom degrad meanwhil raba also involv earli endocytosi egfr subsequ inhibit egfr phosphoryl switch phenotyp phenotyp allevi sepsi induc acut lung injuri mechanist studi demonstr erlotinib suppress glycolysi depend polar via pkmhif pathway promot polar regul ppar induc glutamin metabol collect data elucid depth mechan macrophag activ provid stronger evid support egfr potenti therapeut target treatment sepsi
|
D019446;D018805
|
T047;T046
|
36,344,489
|
viral load dynam sar cov delta omicron variant follow multipl vaccin dose previous infect import aspect vaccin effect impact pathogen transmiss harbor major implic public health polici viral load promin factor affect infect laboratori surrog qrt pcr cycl threshold ct use investig infect relat compon vaccin effect vaccin wane previous observ viral load delta wave less known regard omicron viral load affect vaccin status whether vaccin deriv natur infect protect sustain analyz result individu show recent vaccin reduc omicron viral load effect wane rapid contrast signific slower wane rate demonstr recov covid individu thus vaccin effect decreas morbid mortal relat small effect transmiss omicron measur ct rapid wane call reassess futur booster campaign
|
D000086382;D014765
|
T129;T047;T121;T067
|
36,344,488
|
epigenom wide dna methyl analysi whole blood cell deriv patient gad ocd chines han popul general anxieti disord gad obsess compuls disord ocd high comorbid affect million peopl around world lead huge burden health economi conduct epigenom wide dna methyl studi employ patient gad patient ocd health control explor epigenet alter associ onset differ gad ocd identifi multipl differenti methyl posit dmps region dmrs three dmp gene includ riok cg p dnase cg p psmb cg p two dmr gene uspnl p cplx p associ onset gad ocd three dmps gene includ ldlrap cg p acin cg p scrt cg p three dmr gene wdr p sycp p fama p associ differ gad ocd investig epigenet age chronolog age reveal differ epigenet develop trajectori gad ocd conclus find yield robust model may aid distinguish patient healthi control auc classifi patient gad ocd auc may power precis medicin
|
D000081122;D009771
|
T028;T048
|
36,344,296
|
composit control soft hydrogel surfac layer dimens contact mechan hydrogel soft hydrat polym network wide use research industri due favor properti similar biolog tissu howev long difficult creat hydrogel emul heterogen structur special tissu cartilag one potenti avenu develop structur variat hydrogel mold effect recent discov caus absorb oxygen within mold surfac interf polymer induc dilut gradient densiti surfac layer alter properti howev precis structur gradient surfac layer contact respons yet character knowledg would prove use design composit hydrogel alter surfac characterist fulli character hydrogel gradient surfac layer creat five hydrogel composit vari monom cross linker content encompass variat layer use particl exclus microscopi indent creep experi probe contact respons gradient layer composit experi show dilut structur gradient layer follow evolv contact behavior allow poroelast squeez miniscul pressur stiffer composit thinner gradient layer knowledg potenti use creat hydrogel stiff load bear bulk alter surfac characterist tailor specif tribolog applic
|
D020100;D011108
|
T104;T122
|
36,344,295
|
emerg biomateri technolog control stem cell fate pattern engin tissu organoid abil creat complex three dimension cellular model effect replic structur function human organ tissu vitro potenti revolution medicin model could facilit interrog development diseas process underpin fundament discoveri scienc vast acceler drug develop screen even use creat tissu implant bodi realize potenti howev requir recreat complex biochem biophys cellular pattern tissu remain key challeng field recent advanc driven improv knowledg tissu morphogenesi architectur technolog develop bioengin materi scienc creat multidimension dynam system requir produc complex tissu microenviron articl discuss challeng vitro model tissu organ summar current state art biomateri bioengin system aim address challeng includ top technolog photopattern magnet acoust forc cell origami well bottom pattern use bioprint microfluid cell sheet technolog composit scaffold illustr vari way appli suit need differ tissu applic focuss specif exampl pattern bone tendon interfac kidney organoid brain cancer model final discuss challeng futur prospect appli materi scienc bioengin develop high qualiti tissu structur vitro studi
|
D001672;D062028
|
T063;T122
|
36,344,278
|
associ prestrok physic activ stroke sever mortal intracerebr hemorrhag compar ischem stroke prestrok physic activ may protect brain sever consequ stroke howev previous studi subject includ main ischem stroke case associ prestrok physic activ outcom intracerebr hemorrhag uncertain therefor sought examin associ prestrok physic activ stroke sever caus mortal intracerebr hemorrhag comparison ischem stroke
|
D000083242;D020521
|
T047
|
36,344,272
|
dy variant fabri diseas systemat review meta analysi accumul evid literatur indic strong correl fabri diseas fd phenotyp specif sequenc variat galactosidas alpha gla gene among potenti pathogen clinic relev dy variat patient fd remain debat
|
D000795
|
T047
|
36,339,983
|
phytochem studi plant speci biden pilosa l asteracea croton floccosus euphorbiacea background given chemic rich medicin plant biden pilosa l croton floccosus ecuador consid natur sourc numer medicin method leav dri c c extract character mean phytochem screen verifi presenc secondari metabolit alkaloid reduc sugar phenol flavonoid tannin saponin three extract process carri two solvent differ polar hexan ethanol extract method appli leav plant soxhlet ultrason bath macer latter two room temperatur soxhlet boil temperatur solvent determin total content phenol flavonoid carri use follin ciocalteau colorimetr reaction quercetin standard aluminum chlorid solut measur uv vis spectrophotomet antioxid activ perform dpph radic measur equip result highest content total phenol obtain employ soxhlet method extract materi dri c mg gaeg dri sampl biden pilosa l case croton floccosus mg gaeg dri sampl obtain extract mean macer final antioxid activ diphenyl picryl hydrazyl radic determin found biden pilosa l speci perform better respond better test ic valu gml croton floccosus ic gml conclus follow preliminari phytochem studi biden pilosa l croton floccosus plant provid import inform content secondari metabolit respons dpph radic report first time ecuador may futur use medicin applic
|
D031176;D029802;D019659;D019665
|
T002
|
36,339,975
|
percept health care student toward lectur teach learn method covid era multicentr cross section studi india sudden precipit pandem forc undergradu take refug home desert campus consequ age old classroom person teach learn l method shift lesson conduct onlin previous decad archetyp classroom lectur surviv lot critic face quasi passiv natur l methodolog studi reflect undergradu student percept lectur studi aim evalu undergradu student percept lectur use onlin questionnair item circul undergradu student medic physiotherapi nurs cours three set differ locat privat public health school total respons survey student favor lectur consid indispens undergradu learn prefer kind organ learn teacher experi studi suggest lectur requir mend possibl teacher requir better train applic effect audio visual aid innov techniqu sustain student interest class
|
D000086382
|
T047;T067
|
36,344,222
|
convolut neural network huffman pool handl data insuffici categori novel method anomali detect fault diagnosi rotat compon import part modern mechan equip health status great impact whether equip safe oper recent year convolut neural network wide use identifi health status rotor system previous studi most base premis train set test set categori howev actual oper condit mechan equip complex changeabl real diagnost task usual greater divers pre acquir dataset inconsist categori train set test set make easi convolut neural network identifi unknown fault data normal data fatal equip health manag overcom problem articl propos new method huffman convolut neural network improv general abil model detect task various oper condit first new huffman pool kernel design accord huffman code principl huffman pool layer structur introduc convolut neural network enhanc model abil extract common featur data differ condit second new object function propos base softmax loss intra class loss inter class loss improv huffman convolut neural network abil distinguish differ class data aggreg class data third propos method test three differ dataset verifi general abil huffman convolut neural network diagnosi task multi oper condit compar tradit method propos method better perform greater potenti multi condit fault diagnosi anomali detect task inconsist class space
|
D016571;D005793
|
T170;T041
|
36,344,207
|
workplac violenc imag depart investig type frequenc workplac violenc experienc radiolog technologist identifi technologist use specif imag modal increas risk
|
D064450
|
T054
|
36,344,204
|
student percept learn target practic effect feedback examin second year radiolog technolog student perceiv abil learn base target practic effect feedback provid clinic instructor staff radiograph
|
D007858;D013334
|
T061;T098;T062;T081;T041
|
36,344,200
|
radiolog technologist knowledg comfort explain effect dose examin us radiolog technologist perceiv level knowledg radiat effect dose level comfort communic effect dose inform common imag procedur patient abil compar effect dose differ medic imag procedur
|
D013679;D011871
|
T091
|
36,344,197
|
onlin object structur clinic examin teach accept replac post covid medic educ unit kingdom descript studi coronavirus diseas covid restrict result increas emphasi virtual communic medic educ studi assess accept virtual teach onlin object structur clinic examin osc seri role futur educ
|
D000086382;D013337;D004501
|
T065;T047;T097;T067
|
36,344,196
|
assess global habitat suitabl risk ocean green tide green tide widespread problem harm issu affect protect ocean ecosystem natur resourc scientif assess prevent green tide essenti sustain plan util maritim traffic tourism industri howev suitabl risk habitat domin factor green tide global perspect unknown studi propos novel framework show habitat suitabl risk ocean green tide consid marin environment factor ie sea surfac temperatur sea surfac salin solar irradi chlorophyl concentr sea surfac wind global remot sens imag marin environment factor data studi found suitabl risk green tide area locat north south temper zone marin physic factor expect weaken green tide risk global enhanc green tide risk coastal area green tide north atlant ocean west pacif ocean domin environment factor physic factor respect reduc carbon promot sustain potenti suitabl green tide area may appear high latitud result demonstr risk locat futur trend green tide help sustain plan ocean ecosystem
|
D017753;D055871
|
T070;T082
|
36,344,195
|
assess model pacif northwest harm algal bloom transport decis support tool pacif northwest bloom diatom pseudo nitzschia pn sometim produc domoic acid neurotoxin caus amnes shellfish poison lead harm algal bloom hab event pacif northwest pnw hab bulletin project partnership academ govern tribal stakehold use combin beach offshor monitor data ocean forecast model better understand format evolut transport hab region project produc period bulletin inform local stakehold current forecast condit goal studi help improv forecast model use bulletin prepar retrospect particl track experi use past observ beach pn cell count event identifi like origin juan de fuca eddi known pn hotspot particl track use model simul event varieti beach definit test base water depth distanc offshor defin particl model close enough coast like correspond cell appear intertid zone shellfish diet well varieti observ pn cell threshold determin cell count use describ event would warrant action skill criteria assess determin fraction true posit true negat fals posit fals negat within model comparison observ well varieti deriv model perform metric analysi suggest stakehold purpos use beach definit isobath use pn cell threshold coincid field base sampl pn densiti estim pn cellsl last perform medium resolut km horizont resolut version model compar high resolut km horizont resolut version latter current use forecast pnw hab bulletin project analysi includ direct comparison two model resolut one overlap year result suggest narrow realist beach definit use high resolut model wider beach definit appropri lower resolut model like medium resolut version use analysi overal analysi demonstr import incorpor stakehold need statist approach order generat effect decis support inform oceanograph model
|
D057096;D017377
|
T204;T037
|
36,344,194
|
appar biogeograph trend alexandrium bloom northern europ identifi link climat chang effect adapt action marin dinoflagel alexandrium halim repres perhap signific intens studi genus respect speci divers life histori strategi toxigen biogeograph distribut global magnitud consequ harm algal bloom hab socioeconom impact environment human health risk mitig strategi toxigen alexandrium bloom also explor recent year human adapt action base futur scenario bloom dynam shift biogeograph distribut climat chang paramet remain develop yet implement region scale coclim co develop climat servic adapt chang marin ecosystem project issu address respect past current anticip futur status key hab genera expect benefit enhanc monitor data distribut frequenc alexandrium bloom relat paralyt shellfish toxin pst event key coclim case studi area compris north sea adjac kattegat skagerrak norwegian sea baltic sea eastern north atlant margin sea evalu contemporari histor context past sever decad first evid possibl biogeograph expans alexandrium taxa eastern arctic gateway provid dna barcod signatur various key climat chang indic salin temperatur water column stratif relev alexandrium bloom initi develop identifi possibl influenc chang variabl bloom dynam magnitud frequenc spatial tempor distribut interpret context region ocean climat model climat chang impact indic may play key role select occurr divers alexandrium speci within broader microeukaryot communiti exampl shift higher temperatur lower salin regim predict southern north sea indic potenti increas alexandrium bloom current absent area ecolog socioeconom impact alexandrium bloom effect fisheri aquacultur resourc coastal ecosystem function evalu feasibl effect adapt strategi propos herein emerg climat servic
|
D057231;D004141
|
T070;T204
|
36,344,193
|
identif epigenet histon modif analysi histon lysin methyltransferas alexandrium pacificum alexandrium pacificum toxic dinoflagel caus harm algal bloom hab molecular mechan hab still poor understood especi epigenet level organ growth metabol process affect histon modif import mode epigenet regul studi various type modif includ methyl acetyl ubiquitin phosphoryl pacificum cell identifi use pan antibodi mass spectrometri h modif multiplex assay kit modif abund hkme hkme pacificum vari differ growth condit detect western blot class set domain gene sdgs encod histon lysin methyltransferas analyz total sdg member identifi pacificum sequenc encod complet protein classifi three categori phylogenet analysi conserv domain motif analysi express analysi real time polymeras chain reaction valid show express sdgs signific influenc light nitrogen phosphorus manganes supplement result reveal histon lysin methyl play import role respond hab induc condit studi provid use inform explor role regulatori mechan sdgs rapid growth pacificum
|
D042421;D004141
|
T087;T204
|
36,344,192
|
environment human health socioeconom impact ostreopsi spp bloom nw mediterranean paper summar research conduct partner eu co fund coclim project ascertain ecolog human health econom impact ostreopsi main cf ovata bloom nw mediterranean coast franc monaco spain knowledg necessari design strategi prevent mitig necessari adapt impact event futur region ostreopsi prolifer mediterranean relat massiv mortal benthic organ symptom respiratori cutan irrit human six year epidemiolog studi ostreopsi hot spot catalonia accumul experi french mediterranean nation ostreopsi surveil network confirm main effect bloom human health nw mediterranean impact associ direct exposur seawat high ostreopsi cell concentr inhal aerosol contain unknown irrit chemic produc certain circumst bloom seri mild acut symptom affect entir bodi well ophthalm digest respiratori dermatolog system identifi main remain challeng ascertain effect chronic exposur toxic ostreopsi bloom still mechan involv deleter effect ostreopsi bloom poor understood character chemic natur harm compound synthes ostreopsi well role mucus cell attach benthic surfac requir new technic approach eg metabolom realist standard ecotoxicolog test also necessari investig palytoxin analogu produc cf ovata could transfer marin food web evalu real risk seafood poison area hand implement beach monitor surveil system summer constitut effect strategi prevent impact ostreopsi human health spite confirm noxious effect survey tourist resid nice monaco ascertain socioeconom cost ostreopsi bloom indic occurr event impact poor known general public relationship plausibl near futur increas ostreopsi bloom nw mediterranean coast survey show substanti part popul might continu go beach ostreopsi prolifer thus could expos health risk contrast peopl would visit affect area potenti subsequ negat impact coastal recreat tourist activ howev stage earli accur assess econom impact potenti increas frequenc biogeograph expans event might caus futur
|
D008387;D004141
|
T131;T116;T204
|
36,344,186
|
testicular tumor new develop germ cell sex cord stromal tumor articl review recent advanc potenti futur chang classif testicular germ cell sex cord stromal tumor highlight chang classif system terminolog descript newer entiti discuss approach difficult area diagnost pitfal also includ along util ancillari investig area limit knowledg highlight provid direct futur studi bullet summari form critic care point provid
|
D018312;D013736;D009373
|
T191
|
36,344,185
|
kidney tumor new emerg kidney tumor entiti review summar current knowledg sever novel emerg renal entiti includ eosinophil solid cystic renal cell carcinoma rcc rcc fibromyomat stroma anaplast lymphoma kinas rearrang rcc low grade oncocyt renal tumor eosinophil vacuol tumor thyroidlik follicular rcc biphas hyalin psammomat rcc clinic featur gross microscop morpholog immunohistochemistri molecular genet featur describ diagnosi rest recogn morpholog featur use immunohistochemistri accur diagnosi entitl reduc categori unclassifi renal carcinomastumor lead better clinic manag improv patient prognost
|
D002292;D007680
|
T191
|
36,344,184
|
new develop impact diagnosi exist renal neoplasm recent year sever emerg diagnost entiti describ renal cell carcinoma rcc howev understand well known establish entiti also grown clear cell papillari rcc relabel tumor rather carcinoma view nonaggress behavior renal tumor predomin infiltr pattern import recognit aggress behavior includ fumar hydratas defici rcc smarcb defici medullari carcinoma collect duct carcinoma urotheli carcinoma metastas cancer
|
D002292;D002295;D001749;D007680;D018276
|
T191
|
36,344,183
|
molecular taxonomi immun checkpoint therapi bladder cancer bladder cancer heterogen diseas exhibit wide spectrum clinic patholog featur recent genom studi reveal distinct molecular alter may underli divers clinic behavior bladder cancer lead novel molecular classif intrins molecular subtyp exhibit distinct gene express signatur differ clinicopatholog featur genom alter also underli develop bladder cancer histolog subtyp genom character provid new insight understand biolog bladder cancer improv diagnosi treatment complex diseas biomark aid select patient immun checkpoint therapi
|
D001749
|
T191
|
36,344,182
|
urotheli carcinoma updat stage report patholog chang follow neoadjuv chemotherapi stage report cancer urinari tract undergon major chang past decad meet need improv patient manag substanti progress made howev remain issu requir clariti includ substag pt tumor grade report tumor grade heterogen follow nac multi institut collabor studi prospect data inform accur diagnosi stage report tumor conjunct genom data ultim contribut precis person patient manag
|
D002295;D001749
|
T191
|
36,344,181
|
urotheli carcinoma diverg differenti morpholog subtyp urotheli carcinoma uc known encompass wide spectrum morpholog featur molecular alter approxim invas uc exhibit histomorpholog featur form diverg differenti along epitheli lineag differ subtyp urotheli sarcomatoid differenti recommend percentag diverg differenti subtyp report whenev possibl recent advanc molecular biolog led better understand molecular underpin morpholog variat review highlight histolog characterist diverg differenti subtyp recogn latest version classif updat molecular clinic featur
|
D002295;D001749
|
T191
|
36,344,180
|
updat flat papillari urotheli lesion genitourinari patholog societi consensus recommend report recommend flat papillari urotheli neoplasia publish posit articl genitourinari patholog societi juli collect contribut multidisciplinari expert aim clarifi nomenclatur classif flat papillari urotheli neoplasia controversi issu review discuss recommend includ nomenclatur practic approach import clinic practic
|
D001749;D014571
|
T191
|
36,344,179
|
molecular genet prostat cancer role genom test prostat cancer pca character profound genom heterogen recent advanc person treatment entail increas need genom profil local pca gene express assay support clinic decis regard activ surveil adjuv treatment metastat pca homolog recombin defici microsatellit instabl high msi h cdk defici constitut main action alter alter dna repair gene confer variabl sensit poli adp ribos polymeras inhibitor use genom instabl assay predict biomark still incipi msi assess immunohistochemistri date lack consensus test standard
|
D000067856;D011471
|
T121;T191
|
36,344,178
|
diagnosi patholog report prostat cancer era mri target prostat biopsi histor detect prostat cancer reli upon systemat yet random sampl prostat transrect ultrasound guid biopsi approach nontarget techniqu led detect cancer biopsi upgrad cancer radic prostatectomi multiparametr mri target prostat biopsi allow imag direct approach identif prostat cancer mri target biopsi prostat superior detect clinic signific prostat cancer techniqu becom preval among urologist pathologist need recogn develop impact cancer diagnosi report
|
D053783;D011471
|
T060;T191
|
36,344,177
|
cribriform lesion prostat gland cribriform lesion prostat repres import often diagnost challeng spectrum prostat patholog lesion rang normal anatom variat benign prolif lesion premalign suspici frank malign biolog aggress entiti concept cribriform prostat adenocarcinoma crp intraduct carcinoma prostat idc p particular evolv signific recent year grow bodi evid suggest presenc morpholog import clinic decis make prostat cancer manag therefor accur recognit report crp idc p architectur especi import review discuss contemporari diagnost approach cribriform lesion prostat focus key morpholog featur differenti diagnosi under molecular alter clinic signific report recommend
|
D019048;D011471;D011230
|
T191
|
36,344,176
|
prostat cancer updat grade report gleason score system grade group system facilit accur grade report prostat cancer essenti task surgic pathologist gleason pattern critic recogn signifi risk aggress behavior gleason pattern carcinoma prostat adenocarcinoma radiat androgen therapi effect aberr p express paneth cell like differenti repres pitfal prostat cancer grade although display architectur associ aggress behavior usual prostat adenocarcinoma behav aggress use convent gleason score tumor would signific overst biolog potenti
|
D011471;D002277;D000230
|
T191
|
36,344,172
|
happi age trust gut microb human gut microbiota compris trillion micro organ gut secret metabolit play pivot role support optim bodi organ function dynam malleabl gut microb share bidirect relationship host support health age sex depend manner disrupt gut microbiota decreas divers rich due unhealthi chang lifestyl diet social disconnect alway result unwant outcom host health fuel chronic diseas symptom includ neurodegen diseas thus impair gut microbiota composit result organ declin acceler individu biolog age review evid support bidirect relationship gut microbiota biolog age
|
D000069196;D019636
|
T047;T007;T001
|
36,344,167
|
n glycan branch enzym involv cancer alzheim diseas copd futur perspect past decad group involv studi relat biosynthesi n glycan branch relat glycosyltransferas purifi golgi deriv enzym homogen use classic purif method clone cdna gnt iii iv v vi fut except gnt ix vb obtain homolog clone base primarili data briefli summar signific three major enzym discuss perspect futur studi occas ernesto th birthday celebr
|
D000544;D015061;D009369;D029424
|
T116;T191;T126;T047;T048
|
36,344,159
|
data data burn deep forest net continu imagin technolog develop lead massiv accumul various type data area biolog research result central import databas increas databas relat biolog must structur use control vocabulari also fulli integr whole biolog domain achiev goal must systemat ground biolog evolut exploit avail tool evolutionari systemat contribut understand life process
|
D065928;D005075
|
T045;T070
|
36,344,136
|
year old male patient sever multifoc pneumonia bronchiectasi requir extracorpor membran oxygen year old male patient intermitt asthma joint hypermobl present ed acut hypoxem respiratori distress report experienc cough increas work breath worsen chest pain day present also report fatigu decreas appetit week known fever myalgia recent weight loss medic histori includ two hospit earli childhood viral respiratori ill one requir intub month age gastrostomi tube place short hospit failur thrive secondari aspir base swallow studi weight gain growth improv adequ nutrit gastrostomi tube remov year age newborn screen includ immunoreact trypsinogen normal note hypermobil joint physic examin clinic visit childhood examin result concern hypermobl syndrom diagnosi pursu parent endors healthi child overal occasion cough attribut asthma lifestyl describ sedentari play sport unusu hobbi take daili medic environment exposur report famili histori pulmonari autoimmun connect tissu diseas
|
D001249;D001987;D015199;D011014
|
T061;T047;T050
|
36,344,135
|
year old man chest pain dyspnea year old man came cardiac surgeri clinic pulmonari thromboendarterectomi pte evalu initi appear outsid hospit year earlier chest pain short breath known chronic condit ct pulmonari angiogram ctpa time show fill defect bifurc main pulmonari arteri transthorac echocardiogram reveal mild mitral valv regurgit otherwis result normal hemodynam stabl hypoxem treat sole anticoagul despit adher prescrib apixaban develop progress dyspnea reduc exercis toler subsequ year repeat ctpa perform month initi present show persist fill defect level pulmonari arteri bifurc new extens complet occlud right main pulmonari arteri pulmonari angiogram confirm complet occlus right heart catheter reveal precapillari pulmonari hypertens mean pulmonari arteri pressur mm hg anticoagul transit enoxaparin presum apixaban treatment failur investig hypercoagul condit initi lupus anticoagul test result posit meet criteria antiphospholipid syndrom negat anticardiolipin glycoprotein antibodi assay antithrombin iii protein c prothrombin gene factor v leiden mutat produc normal result
|
D004691;D004417
|
T061;T184
|
36,344,134
|
year old woman dyspnea multipl pulmonari nodul mediastin lymphadenopathi year old woman present institut gradual worsen short breath bilater lower extrem edema week durat associ complaint cough intermitt hemoptysi medic histori signific hypertens hypothyroid former cigarett smoker pack year smoke histori recent travel histori pet dog home six month current hospit evalu cough reveal mediastin lymphadenopathi outsid institut underw evalu endobrachi ultrasound procedur outsid facil week current admiss procedur demonstr acut chronic inflamm one specimen show atyp cell cytopatholog growth bacteri fungal mycobacteri cultur treat empir oral steroid presum sarcoidosi howev result clinic benefit progress symptom present institut
|
D055613;D000072281
|
T033;T047
|
36,344,133
|
year old girl diagnos sting associ vasculopathi onset infanc savi lung transplant year old girl receiv lung transplant chronic respiratori failur develop fever c twice week start month surgeri multipl papulopustul skin wax wane month develop blood ting sputum treat tripl immunosuppress includ prednisolon tacrolimus mycophenol mofetil lung transplant symptom appear prednisolon dose reduct
|
D016040;D014652
|
T061;T047
|
36,344,132
|
case thrombot microangiopathi acut sarcoidosi although sarcoidosi establish caus multiorgan dysfunct acut present thrombot microangiopathi result sever renal hematolog sequela report describ case patient present hypercalcemia pancreat acut renal failur follow microangiopath hemolyt anemia although signific respiratori symptom thorac radiolog mediastin lymph node biopsi result keep sarcoidosi under caus multisystem present corticosteroid commenc clinic biochem improv novel case highlight need consid sarcoidosi part differenti diagnosi unusu multiorgan present earli multidisciplinari involv case permit optim treatment
|
D057049;D058186;D012507
|
T047;T037
|
36,344,109
|
chang platelet function coagul transcathet aortic valv implant evalu thromboelastographi possibl hypercoagul periop period transcathet aortic valv implant tavi note howev still controversi regard appropri periop antithrombot therapi studi investig coagul platelet function tavi periop period use thromboelastographi teg platelet map
|
D065467
|
T061
|
36,344,108
|
design rational inferior vena cava lung ultrasound guid therapi acut heart failur caval us ahf studi randomis control trial patient hospitalis acut heart failur ahf readmit within day discharg most due persist congest discharg howev optim evalu decongest clear defin necessari implement new tool identifi subclin congest guid treatment
|
D014682;D006333
|
T023;T046;T047
|
36,344,107
|
impact virtual realiti cardiac rehabilit relat anxieti protocol systemat review meta analysi cardiac rehabilit proven benefici cardiovascular patient strong recommend secondari prevent coronari event howev overal utilis cardiac rehabilit often low addit novel method rehabilit may increas overal complianc cardiac rehabilit use virtual realiti vr adopt varieti therapeut way physic rehabilit neurolog diseas rehabilit various psychiatr ill postcanc rehabilit breast cancer survivor meta analysi wish assess whether addit vr fulli immers non immers lead improv anxieti function capac compar standard cardiac rehabilit phase rehabilit process
|
D000072038;D000076142
|
T061;T066
|
36,344,105
|
respond one rural communiti primari care need invest workforc broad communiti stakehold engag lack access high qualiti primari care shown contribut urban rural health dispar describ model academ health system made target primari care invest address rural health dispar build health workforc ensur sustain
|
D012424;D019035
|
T098;T073;T093;T102;T058
|
36,344,104
|
develop school base telehealth program equiti strategi educ health care school base telehealth program shown potenti address educ health need elementari student north carolina cone health prototyp area endem poverti low health literaci allow creation demand care kept children school decreas earli dismiss reduc burden cost urgent health care famili
|
D012574;D017216
|
T092;T058;T073
|
36,344,103
|
north carolina health workforc data ca nt tell us north carolina countri best health workforc suppli data cooper licens board data nt encompass health care worker workforc demand data difficult track even harder know mani health care worker truli need improv state health
|
D006280;D006282
|
T081;T097
|
36,344,102
|
build strong inclus workforc health convers north carolina commerc secretari machell baker sander health secretari kodi kinsley north carolina face signific health workforc shortag exacerb covid pandem meet challeng depart commerc depart health human servic priorit equiti creativ collabor
|
D058873;D000086382
|
T047;T067
|
36,344,101
|
build workforc health north carolina covid expos exacerb histor shortag maldistribut health workforc north carolina edit north carolina medic journal highlight work done state address need call intent persist approach plan develop workforc need produc health
|
D000086382
|
T047;T067
|
36,344,100
|
cost effect homeless care transit program durham homeless care transit background transit care medic respit program provid assist peopl experienc homeless move acut care communiti set program address issu may fall outsid reach tradit medic care yet profound impact health vulner popul articl focus cost effect durham homeless care transit dhct program method intervent studi dhct program use comparison group peopl experienc homeless refer particip encount level data aggreg quarter segment charg reimburs abstract person refer descript statist comput model charg reimburs creat use ordinari least squar ol regress compar util month pre post referr result patient refer dhct program n primarili non hispan black male uninsur averag chronic condit averag age year sd variabl among charg reimburs base health care visit type negat associ treatment charg indic part dhct program led lower charg post referr limit studi limit lack access line item detail charg reimburs payer mix conclus evid benefit patient transit care medic respit program substanti increas overal societ cost care howev health system common requir evid cost save benefit return invest
|
D010360;D006703
|
T033;T058;T098;T095
|
36,344,099
|
explor north carolina transit whole person integr care provid perspect result exploratori survey background quit time mani north carolina practition health care leader advoc whole person care signific movement toward whole person approach health state howev challeng remain despit continu momentum build year articl report exploratori survey north carolina primari care behavior health provid method provid recruit statewid profession associ network particip survey regard experi deliv whole person care survey includ demograph provid clinic type inform profession experi question focus whole person care practic result result survey demonstr provid report acknowledg attempt practic whole person care still barrier overcom reliev administr burden chang expand servic understand reimburs integr servic difficulti recruit retain provid limit sampl includ nurs practition primari care behavior health disciplin thus inform gather survey may repres train experi nurs practition paradigm shift north carolina deliveri care addit research made everi attempt distribut survey statewid area state repres other conclus obstacl seamless provid whole person care remain state health leader provid north carolina communiti need work togeth reduc elimin obstacl ensur deliveri integr behavior health whole person care
|
D019033
|
T058;T093
|
36,344,098
|
fortifi north carolina workforc health meet current futur challeng two new north carolina institut medicin task forc report make recommend bolster state public health workforc new fund partnership effort prepar futur health crise achiev health equiti support grow economi
|
D006280;D000069576
|
T081;T080
|
36,344,097
|
emerg trend primari care network address workforc crisi build resili high perform primari care infrastructur north carolina primari care network policymak align effort creat pathway student traine new physician thrive primari care describ shift primari care landscap current workforc initi polici option achiev goal
|
D010820
|
T097
|
36,344,092
|
develop health care faculti address need north carolina divers popul address communiti need improv popul health well health care provid develop health care workforc requir faculti address need north carolina divers rural popul best accomplish build interdisciplinari cross function servic learn experi develop communiti academ partnership coalit
|
D000075485
|
T058
|
36,344,091
|
challeng opportun graduat medic educ step keep physician train north carolina except chang health care present mani challeng opportun north carolina except graduat medic educ program step keep program except includ boost leadership train champion well expand rural train describ
|
D004503;D010820
|
T065;T097
|
36,344,090
|
pathway program north carolina histor perspect diversifi medic workforc program must develop enhanc prepar student minorit underresourc communiti compet admiss medic educ north carolina rich histori provid pathway program assist minorit student develop physician serv communiti emerg
|
D004501;D010820
|
T065;T097
|
36,344,089
|
keep north carolina health care workforc well support well need north carolina health care workforc crucial maintain robust health care deliveri system north carolinian organ policymak provid need support ensur well health care worker
|
D006282;D005006
|
T098;T102;T097
|
36,344,087
|
unfulfil request postpartum tubal ligat southern tertiari care center background nation multipl barrier lead women request postpartum tubal ligat receiv prior discharg aim identifi characterist associ unfulfil request postpartum tubal ligat tertiari medic center south method conduct retrospect chart review women deliv live infant document desir postpartum steril septemb novemb primari outcom receipt postpartum steril prior discharg use chi squar mann whitney u test descript analys result one thousand seventi two women deliv live infant institut sampl frame one hundr twenti four document desir postpartum steril eighti one women receiv postpartum steril women women deliv cesarean like receiv postpartum steril deliv vagin p less like receiv desir postpartum steril multiprong process chang need fulfil patient steril request
|
D013246
|
T061;T074
|
36,344,085
|
potenti univers influenza virus like particl vaccin express chimer cytokin efficaci current influenza vaccin frequent reduc antigen drift trade develop improv vaccin broad cross protect activ influenza virus studi success construct chimer cytokin cc compris protein influenza neuraminidas stalk interleukin produc virus like particl vlps contain cc influenza hemagglutinin ha protein use baculovirus system eri silkworm pupa protect efficaci ccha vlp vaccin evalu mice ccfkhha vlp vaccin increas surviv rate balbc mice infect lethal dose prh hkh virus respect result suggest ccha vlp success induc potent cross reactiv protect immun infect homolog heterolog subtyp influenza virus first studi design cc contain ha vlp vaccin valid protect efficaci
|
D007252;D007251;D058425;D009976
|
T129;T047;T121;T109
|
36,344,064
|
editori commentari restor nativ menisc anatomi medial meniscus allograft transplant augment meniscotibi ligament may decreas menisc graft extrus studi shown signific clinic improv medial meniscus allograft transplant mmat good long term graft survivorship progress osteoarthr still occur even presenc intact graft sever factor potenti explain lack chondroprotect despit graft survivorship includ menisc degener tear remodel initi procedur major factor contribut progress osteoarthr menisc extrus seen patient seem issu medial meniscus transplant compar later present even immedi postop graft without extrus provid protect effect similar nativ meniscus greater mm extrus lead near complet loss protect effect reconstruct meniscotibi ligament addit standard mmat may signific decreas menisc extrus optim graft size qualiti menisc root posit best prevent extrus restor nativ biomechan
|
D008592;D010003
|
T023;T047
|
36,344,063
|
smaller iatrogen defect creat insid compar insid meniscus repair devic human cadaver model investig pattern diamet iatrogen defect menisc repair devic impos menisc tissu determin whether repair induc defect pattern diamet differ across devic
|
D000070600;D000072600
|
T023;T037
|
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