PMID
int64 35.7M
36.4M
| Title/Abstract
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36,344,910
|
combin thorac epidur analgesia patient control intraven analgesia versus tradit thorac epidur analgesia postop analgesia earli recoveri laparotomi prospect singl centr random control trial thorac epidur analgesia tea alway first choic postop pain treatment associ complic contraind may limit use studi put forward new analges strategi combin tea patient control intraven analgesia pcia optim tea
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D015360
|
T061
|
36,344,903
|
inhibitori effect schisandron hemolysin express combat methicillin resist staphylococcus aureus infect due increas antibiot resist target bacteri virul factor gain interest altern strategi develop novel class anti infect agent critic role hemolysin hla indispens virul determin pathogen staphylococcus aureus render virul factor appeal target effect therapeut applic herein identifi natur compound schisandraon effect hla inhibitor could inhibit hla product thus hemolyt activ dose depend manner without affect growth aureus also found addit schisandron could regul transcript level hla agra rnaiii signific allevi hla mediat injuri cell co cultur aureus vivo studi suggest schisandron combin antibiot ceftiofur exhibit signific therapeut effect aureus infect find reveal role schisandron inhibit activ hla believ promis anti virul candid combat mrsa pneumonia
|
D055624;D001427;D011023;D013203
|
T123;T007;T116;T131;T047
|
36,344,866
|
investig arsenic contamin groundwat use hydrid generat atom absorpt spectrometri valid hydrid generat atom absorpt spectrometri hg aa method use investig total arsenic groundwat optim experiment condit concentr arsenic groundwat analys rang gl method detect limit gl recoveri field high repeat method use observ total arsenic pollut groundwat collect phu tho provinc vietnam total groundwat sampl analys result show arsenic pollut signific sampl higher maximum permiss level arsenic contamin sampl total arsenic ten time higher gl maximum permiss level arsenic pollut sourc also consid compar arsenic level groundwat arsenic surfac water area thus use high accuraci sensit method hg aa suppli valuabl data groundwat pollut water resourc manag environment protect
|
D001151;D014874;D060587
|
T121;T070;T082;T131;T196;T081
|
36,344,854
|
combin statist method detect potenti outlier groundwat qualiti time seri qualiti control larg scale monitor network requir use automat procedur detect potenti outlier unambigu reproduc manner paper describ methodolog combin exist statist method accommod specif characterist measur data obtain groundwat qualiti monitor network measur seri show larg varieti dynam often compris measur measur data normal distribut measur seri may contain sever outlier may trend seri andor measur may detect limit furthermor detect limit may vari time methodolog outlier detect describ paper use robust regress order statist ros deal measur valu detect limit addit biweight locat estim appli filter tempor trend seri subsequ outlier detect done z score space tune paramet use attun robust accuraci given dataset user requir method appli data dutch nation groundwat qualiti monitor network consist approxim monitor well prove work well general detect outlier top bottom regular measur rang around detect limit given divers exhibit measur seri expect method give satisfactori result measur valu identifi method potenti outlier therefor alway need assess basi expert knowledg consist measur data andor addit research
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D004784;D060587
|
T081;T070;T082;T057
|
36,344,843
|
benefici featur pediococcus starter cultur inhibitori activ probiot benefit pediococci lactic acid bacteria lab use centuri product tradit ferment food ferment abil explor modern food process industri use pediococci starter cultur enabl product ferment food distinct characterist furthermor pediococci strain produc bacteriocin antimicrobi metabolit amm pediocin increas explor bio preserv various food matric due versatil inhibitori spectrum pediococci bacteriocin amm extens research food industri also veterinari human medicin pediococci evalu potenti probiot differ benefici area applic associ human anim health main taxonom characterist pediococci speci present well potenti role applic starter cultur bio preserv probiot candid
|
D019936;D001430;D056546
|
T123;T007;T116
|
36,344,838
|
navig italian region imag biobank promot precis medicin oncolog patient navig italian region project boost precis medicin oncolog aim make predict prevent personalis advanc translat research base quantit imag integr omic analys project goal develop open imag biobank collect preserv larg amount standardis imag multimod dataset includ comput tomographi magnet reson imag positron emiss tomographi data togeth correspond patient relat omic relat relev inform extract region healthcar servic use adapt privaci preserv model project base open sourc imag biobank open scienc orient virtual research environ vre avail integr omic multi imag data three use case prostat cancer rectal cancer gastric cancer collect data confin navig ie standard novel imag biomark non imag data health agenc data use creat digit patient model support reliabl predict diseas phenotyp risk stratif vre reli well establish infrastructur call dscienceorg provid multiset infrastructur process integr omic data extract specif radiom signatur identif test novel imag biomark big data analyt artifici intellig
|
D057285;D001185
|
T061;T090;T091;T073;T066
|
36,344,823
|
associ urinari prostaglandin e metabolit mortal among adult prostaglandin play critic role inflammatori respons investig associ urinari pge stabl end product prostaglandin e pge overal caus specif mortal examin potenti effect modifi obtain urinari pge level non cancer adult previous case control studi nest shanghai women health studi shanghai men health studi two cohort studi conduct shanghai china mortal data modifi factor associ urinari pge obtain parent cohort studi use linear regress model found high urinari pge level signific associ low educ heav smoke old age urin collect abdomin obes use cox proport hazard model found increas per standard deviat urinari pge level signific associ overal mortal adjust hazard ratio confid interv particular death cardiometabol diseas adjust hazard ratio confid interv increas death risk persist across differ time interv follow stronger among particip younger p caus mortal p death cardiometabol diseas urin collect perhap among higher educ
|
D015232;D002318
|
T125;T121;T047;T109
|
36,344,815
|
classif flood generat process africa river flood larg societ econom impact across africa despit import topic littl known main flood generat mechan africa studi base flood event occur catchment flood event classifi identifi differ flood driver excess rain long rain short rain excess rain satur soil western africa long rain catchment northern southern africa two domin mechan contribut flood event arid index strong relat spatial repartit differ flood generat process show climat control flood signific chang detect relat import driver time rather short time seri avail prevent robust assess flood driver chang catchment major implic result underlin import soil moistur dynam addit rainfal analyz evolut flood hazard africa
|
D055868;D045483
|
T070
|
36,344,812
|
mir diagnost biomark potenti therapeut target system sclerosi system sclerosi ssc scleroderma multiorgan rheumatoid diseas character skin tighten organ dysfunct due fibrosi vascular damag autoimmun specif caus discov ill henc effect treatment exist hand due lack diagnost biomark capabl effect specif differenti patient earli diagnosi possibl due potent regulatori role molecular pathway microrna among novel candid diagnosi treatment diseas like ssc mir microrna known role pathogenesi fibrosi cancer employ similar signal pathway henc hypothes mir could dysregul blood individu affect ssc might use diagnosi treatment diseas blood collect ssc patient limit diffus diagnos rheumatologist accord acraular criteria follow rna isol cdna synthesi real time qpcr perform sampl use taq man probe data analyz ct method also potenti target mir evalu use bioinformat reveal mir signific regul ssc patient comparison healthi individu differ mir express limit diffus ssc patient besid mir found target sever contribut factor ssc seem mir protect role ssc downregul could result diseas onset base bioinformat analys specul mir like target factor contribut pathogenesi ssc elev upon downregul mir henc mir mimic could consid potenti therapeut agent treatment ssc futur studi sinc differ observ limit diffus patient group unlik microrna role diseas progress accord roc analysi qpcr data mir could employ valuabl diagnost biomark ssc
|
D012595;D035683
|
T123;T047;T114
|
36,344,810
|
optim aggreg spheroid model asm select high efficaci drug various three dimension cell cultur method develop implement tumor model similar vivo howev convent cell cultur method limit difficulti use extracellular matrix ecm low experiment reproduc complex cell cultur protocol difficulti appli high array plate plate therefor detail protocol relat robust aggreg spheroid model asm product optim propos special design wet chamber use implement asm use hepatocellular carcinoma hcc cell line condit establish ice step aggreg cell one place optim ecm gelat step immunofluoresc stain main use simultan analyz drug efficaci chang drug target biomark appli stain method asm model confoc microscopi imag deconvolut imag analysi also success perform compar studi drug respons convent high throughput screen hts hts show comprehens rang drug efficaci analys hcc cell line enabl select drug efficaci analysi fda approv drug sorafenib suggest increas drug resist hts condit reduc analyt discrimin drug efficaci also drug efficaci analyz select compar convent hts assay therefor hts base drug efficaci analysi method use autom cell spotterscann pillar platewet chamber propos asm fabric protocol suitabl platform analyz target drug efficaci hcc cell
|
D006528;D008113
|
T191
|
36,344,809
|
impact resili protect factor health relat qualiti life psycholog dimens among adolesc experi peer victim peer victim negat impact health relat qualiti life hrqol adolesc howev person skill person resili could play signific role relationship context studi aim analys resili moder relat peer victim hrqol psycholog dimens sociodemograph data peer victim psycholog domain hrqol resili measur sampl secondari school student use follow scale adolesc peer relat instrument bulli kidscreen brief resili cope scale differ multivari analys carri use linear regress process tool use examin moder role resili john neyman post hoc approach quantifi moder result suggest resili could moder associ physic p verbal victim p mood emot dimens adolesc hrqol nevertheless regul influenc appear faint r resili show moder effect social victim psycholog dimens hrqol conclud resili could function protect factor weak regul negat associ physic verbal victim psycholog sphere adolesc hrqol
|
D058445;D019548
|
T068;T098;T048
|
36,344,808
|
anti biofilm activ caffein uropathogen e coli mediat cur biogenesi biofilm assemblag sessil microorgan form extracellular matrix around mediat attach surfac major compon extracellular matrix uropathogen e coli enterobacteriacea cur fiber make biofilm robust resist antimicrobi therefor imper screen antibiofilm compound impair biofilm format present studi investig cur depend antibiofilm activ caffein upec strain cft commens strain e coli k mgcaffein signific reduc biofilm format upec e coli k respect mm caffein determin crystal violet assay result confirm fluoresc microscopi scan electron microscop sem caffein signific reduc cytotox surviv upec molecular dock analysi reveal strong interact caffein cur regul protein csg e coli qrt pcr data also show signific downregul express csgba csgdefg operon mm mm caffein find reveal caffein could inhibit e coli biofilm format regul cur assembl thus may use altern therapeut strategi treatment chronic e coli biofilm relat infect
|
D056689;D004927;D029968
|
T047;T007;T116
|
36,344,807
|
interact folat intak genet predictor gene express level associ colorect cancer risk observ studi shown higher folat consumpt associ lower risk colorect cancer crc understand whether genet risk factor interact folat could elucid under mechan aggreg function relev genet variant set base variant test higher power detect gene environ g e interact may provid inform under biolog pathway investig interact folat consumpt predict gene express colorect cancer risk across genom use variant weight predixcan model colon tissu specif gene express priori variant inform set base g e approach harmon total folat intak mcgday base dietari intak supplement use across cohort case control studi calcul sex studi specif quantil analys perform use mix effect score test interact folat genet predict express gene avail genet predict express pool result across studi total case colorect tumor control european ancestri use fals discoveri rate identifi gene suggest evid interact found suggest evid interact folat intak crc risk gene includ glutathion transferas alpha gsta p e tonsuko like dna repair protein tonsl p e aspartylglucosaminidas aga p e identifi three gene involv prevent repair dna damag may interact folat consumpt alter crc risk glutathion antioxid prevent cellular damag downstream metabolit homocystein metabol gsta tonsl part complex function recoveri doubl strand break aga play role lysosom breakdown glycoprotein
|
D005492;D015179
|
T121;T191;T127;T109
|
36,344,806
|
develop intrins health risk predict model camera base monitor older adult live alon number older adult korea increas along number depress older patient caus depress older adult includ social isol neglig interact other irregular nutrit habit self neglig ie engag activ factor self neglig social isol irregular nutrit habit defin inher health risk studi detect factor deriv long term monitor current monitor system older adult sever limit focus emerg fall therefor studi goal perform long term monitor use camera order captur physic characterist older adult etri activityd data use train skeleton base action recognit algorithm posecd use defin frame time taken one action built monitor system enabl long term monitor older adult perform multipl action detect one video reliabl monitor system accuraci precis recal f success establish health monitor older adult older adult monitor technolog expect improv qualiti medic servic medic environ well object activ daili live test depend observ daili life detect
|
D000203;D000091502
|
T033;T056;T082;T080
|
36,344,775
|
intron encod cistron transcript minim invas monitor code non code rnas despit fundament role assess patho physiolog cell state convent gene report follow gene express leav scar protein substanti alter matur messeng rna multi time point measur non code rnas current imposs without modifi nucleotid sequenc alter nativ function half life local thus develop intron encod scarless programm extranuclear cistron transcript inspect minim invas transcript report embed within intron gene interest post transcript excis inspect result matur endogen rna without sequenc alter addit engin transcript leav nucleus hijack nuclear export machineri subsequ translat report effector protein showcas use monitor interleukin il cell activ track transcript dynam long non code rna lncrna neat crispr interfer mediat perturb inspect method monitor gene transcript without alter matur lncrna messeng rna target interest
|
D062085
|
T123;T114
|
36,344,755
|
genet divers popul structur saccharomyc cerevisia isol turkish sourdough ipb retrotransposon marker molecular dna marker valuabl tool analyz genet variat among yeast differ popul reveal genet differ autochthon strain studi employ inter primer bind site ipb retrotransposon polymorph assess genet variat popul structur saccharomyc cerevisia isol four differ region turkey nine select ipb primer amplifi reproduc scorabl band polymorph averag polymorph fragment per primer averag polymorph inform content resolv power respect analysi molecular varianc amova reveal signific p genet differ within popul popul unweight pair group mean arithmet upgma dendrogram group cerevisia strain two main cluster highest probabl data elucid popul structur obtain k obvious genet discrimin popul accord geograph region upgma support princip coordin analysi howev individu closer provinc popul like group togeth close result indic ipb polymorph use tool reveal genet divers autochthon cerevisia strain may import product sourdough bake good
|
D018626;D012441
|
T123;T004;T114
|
36,344,753
|
honeybe associ lactic acid bacteria probiot potenti human use studi aim identifi lactic acid bacteria lab isol honeybe api mellifera worker larva detail determin function probiot properti total strain classifi base morpholog biochem characterist preliminari probiot properti strain molecular identifi use rrna antimicrobi activ toler digest condit aggreg abil investig antimicrobi properti strain test wide rang human pathogen strain show hemolysi contain bacteriophag consid safe strain surviv check bile ph content promis highest autoaggreg rang h test lab strain mark exhibit coaggreg listeria monocytogen escherichia coli accord result test bacteria show signific antagonist effect pathogen posit probiot characterist compat vitro gastrointestin tract condit result suggest api mellifera lab symbiont may probiot potenti effect safe candid human use studi provid addit develop current knowledg defin detail honeybe associ bacteria determin probiot potenti
|
D056546;D019936;D008089
|
T007
|
36,344,744
|
cervic microendoscop laminoplasti induc clinic resolut disc herniat patient singl three level myelopathi studi aim explor effect resorpt cervic disc herniat cdh clinic outcom surgeri cervic microendoscop laminoplasti cmel common prefer anterior corpectomi fusion appli patient level degen cervic myelopathi dcm dcm patient level dcm underw either conserv treatment cmel conserv treat patient case cdh volum remain unchang improv joa vas score convers patient level dcm prospect enrol exhibit profound decreas cdh volum cdhs regress cdhs regress cdhs larg regress respect meanwhil joa vas score improv differ way intrigu cdh volum chang correl signific elev joa score indic associ clinic cdh resolut neurolog recoveri show cmel induc clinic relat diminish cdh allevi clinic symptom patient level myelopathi could help avoid anterior dissect disc extent
|
D065406;D007405;D013118;D001855
|
T061;T047
|
36,344,742
|
chromosom level genom popul genom reveal evolutionari characterist conserv status chines indigen gees gees herbivor bird play essenti role agricultur economi construct chromosom level genom chines indigen goos xingguo gray goos xgg anser cygnoid analyz adapt fat storag capac goos liver evolut anatida genom resequenc gees use investig genet relationship gees support dual origin gees anser cygnoid anser anser chines indigen gees show higher genet divers european gees scientif conserv program establish preserv genet variat breed also find bp insert endothelin receptor b subtyp ednrb determin white plumag chines domest gees natur mutat linkag allel rapid increas frequenc result genet hitchhik lead format complet differ haplotyp white gees strong artifici select genom resourc find facilit marker assist breed gees provid foundat research gees genet evolut
|
D005777;D004272
|
T123;T012;T114
|
36,344,741
|
shift global flood time climat chang impact flood magnitud also flood time paper studi shift flood time gaug station global shift flood time relationship three influenti factor maximum day precipit soil moistur excess snowmelt investig clear global pattern mean flood date winter dec feb across western coastal america western europ mediterranean region summer jun aug north america alp indian peninsula central asia japan austral summer dec feb south africa north australia area shift flood time trend day per decad earlier day per decad delay earlier flood found extens north america europ northeast australia delay flood prevail amazon cerrado south africa india japan earlier flood time north america europ caus earlier snowmelt delay extrem soil moistur excess precipit joint led delay flood around monsoon zone includ south africa india japan studi provid insight shift mechan flood time support decis global flood mitig impact futur climat chang
|
D055868;D057231
|
T070
|
36,344,740
|
associ treatment delay stage mortal breast cancer nationwid cohort studi taiwan breast cancer fifth lead caus cancer death global retrospect studi investig effect diagnosi first treatment interv dfti relat factor cancer specif surviv patient breast cancer includ patient newli diagnos breast cancer cox proport hazard model use analyz hazard ratio hr mortal various dftis hrs day dfti group differ signific compar refer group dfti day stratifi patient accord initi tumor stage age found patient age year stage ii breast cancer treat day diagnosi fold higher mortal risk confid interv cis respect patient age year stage iv breast cancer treat within day diagnosi fold higher mortal risk cis respect conclus dfti associ mortal patient stage ii iv breast cancer especi older age
|
D001943
|
T191
|
36,344,739
|
treatment burden among patient heart failur attend cardiac clinic tikur anbessa special hospit explanatori sequenti mix method studi emerg evid hypothes patient heart failur suscept experi treatment burden despit fact attempt made far address neoter construct sub saharan african health care context henc studi aim assess patient health care provid perspect decreas treatment burden among patient heart failur attend adult cardiac clinic tikur anbessa special hospit tash explanatori sequenti mix method studi conduct adult cardiac clinic tash addi ababa ethiopia august septemb simpl random purpos sampl techniqu employ select particip quantit qualit studi respect descript analysi done summar quantit data logist regress analysi perform identifi predictor treatment burden p valu consid declar statist signific qualit data analyz use themat analysi total patient enrol quantit studi qualit studi patient health care provid five nurs six medic doctor includ particip mean global treatment burden questionnair tbq score approxim n patient indic high treatment burden tbq global score median global score higher educ level adjust odd ratio aor confid interv ci presenc two comorbid aor ci daili intak five pill aor ci poor medic avail aor ci presenc medic advers effect aor ci higher month cost medic aor ci predictor treatment burden patient healthcar provid proposit primarili focus improv self care manag structur organ clinic hospit healthcar system provis find demonstr substanti proport patient face low level treatment burden studi unveil improv self care manag structur organ clinic healthcar system provis paramount import reduc treatment burden henc factor affect treatment burden consid design tailor healthcar intervent patient heart failur
|
D006761;D006333
|
T047;T046;T073;T093
|
36,344,737
|
use machin learn strategi solv psychometr problem valid scale clinic use common procedur medicin psycholog applic comput method present new strategi estim construct valid criterion valid xgboost random forest support vector machin learn algorithm employ order make predict base pattern particip respons systemat control comput experi artifici experi whose result guarante accord find approach capabl achiev construct criterion valid therefor could provid addit layer evid tradit valid approach particular studi examin extent measur item infer theoret relat item well extent inform carri given construct translat theoret compat normat scale base construct therebi provid inform construct valid well replic clinic decis rule sever partit therebi provid inform criterion valid
|
D000069550;D060388
|
T081;T066
|
36,344,735
|
cannabidiol affect breast meat volatil compound chicken subject differ infect model studi demonstr use dietari cannabi deriv cannabidiol cbd alter stress respons chicken examin effect meat volatil compound voc subject chicken dysbiosi via c perfringen infect escherichia coli lipopolysaccharid lps treatment investig potenti link meat voc cecal bacteri activ amelior effect cbd cecal bacteri product short chain fatti acid scfas close correl meat voc cbd supplement reduc format breast meat spoilag voc includ alcohol trimethylamin pentano acid challeng bird part decreas cecal putrefact scfa product meat voccec scfa relationship differ accord challeng cbd attenu effect c perfringen infect better effect lps challeng meat voc find provid new insight interact among bioactiv agent supplement gut microbiota activ meat properti bird
|
D002645;D002185
|
T121;T012;T109
|
36,344,733
|
circul thrombospondin level reflect fibrosi sever diseas activ hcv infect patient among sever secret glycoprotein belong thrombospondin famili thrombospondin tsp involv various function includ collagenfibrin format liverserum tsp level correl liver fibrosi stage diseas activ nonalcohol fatti liver diseas studi investig whether serum tsp associ clinicopatholog featur hepat c virus hcv infect patient well total patient hcv undergon liver biopsi retrospect enrol divid discoveri cohort n valid cohort n discoveri cohort serum tsp level moder correl liver fibrosi stage r p activ grade r p area receiv oper characterist curv tsp predict sever fibrosi f compar better autotaxin fib index apri discoveri cohort find close replic valid cohort moreov comprehens liver genet analysi hcv infect patient confirm express thbs gene encod tsp signific higher sever fibrot f f patient circul tsp level may reflect sever hepat fibrosisinflamm hcv infect patient
|
D019698;D006526
|
T047
|
36,344,729
|
design fabric applic self spiral pattern driven print actuat self spiral actuat wide found natur high research actuat applic valu self lock self assembl four dimension print new generat addit manufactur smart materi shown great potenti fabric multi function custom structur microarchitectur design bilay actuat could bring flexibl diversifi self spiral behavior possibl practic applic comb print work investig stimuli effect fiber pattern fabric paramet self spiral behavior bilay actuat via experiment theoret method work may potenti provid pattern design guidanc print self spiral actuat meet differ applic requir
|
D066330
|
T073
|
36,344,722
|
number examin requir accur predict progress central degre visual field test glaucoma purpos studi investig number examin requir precis predict futur central degre visual field vf test evalu effect fit non linear model includ quadrat regress exponenti regress logist regress estim robust regress model eye glaucoma eye open angl glaucoma patient minimum humphrey field analyz sita standard vf test analyz studi use trend analysi ordinari least squar linear regress olslr first second third futur vfs predict point wise pw manner use vari number prior vf sequenc mean absolut error mae calcul number vfs need reach minimum confid interv ci mae olslr investig also examin effect appli non linear model predict first second third futur vfs use olslr minimum mae obtain use vf db vf db vf db respect reach ci mae vfs need first second third futur vf predict respect improv observ appli non linear regress model conclus approxim vfs need achiev accur predict pw vf sensit degre central vf
|
D005902;D005901
|
T047
|
36,344,720
|
real world experi intraven ferric derisomaltos evalu safeti efficaci report uk ferric derisomaltos fdi monof use clinic practic treat iron defici safeti efficaci fdi robust evalu larg real world studi retrospect multicentr audit base observ studi provid pragmat inform safeti clinic respons fdi across therapi area patient popul help facilit treatment decis particip site provid data medic record adult receiv fdi infus primari outcom incid advers reaction within hour fdi infus secondari outcom includ chang baselin haemoglobin ferritin month post infus total site provid data total fdi treat patient patient femal age year surgeri main hospit specialti incid record advers reaction hypersensit reaction anaphylaxi respect regardless baselin anaemia status statist signific increas haemoglobin ferritin observ baselin month follow fdi treatment p improv haemoglobin pronounc hospit specialti oper blood loss expect surgeryobstetr compar blood loss expect studi provid real world clinic evid low risk advers reaction fdi across divers patient popul provid reassur intraven iron associ serious toxic find may inform chang intraven iron deliveri provid effect therapi patient need
|
D008320;D018798
|
T121;T047;T109
|
36,344,718
|
impact elev bodi mass index cumul live birth rate obstetr safeti women undergo assist reproduct technolog studi evalu impact elev bodi mass index bmi short long term outcom vitro fertil ivf intracytoplasm sperm inject icsi treatment total patient undergo ivficsi fresh cycl subsequ frozen embryo transfer cycl divid normal kgm high bmi kgm group ovarian respons pregnanc outcom safeti mother fetus main outcom measur furthermor multivari analysi use determin whether bmi associ cumul live birth rate clbr result show younger women year clbr signific reduc high bmi group compar normal bmi control accompani fewer retriev oocyt avail embryo addit incid hypertens disord pregnanc fetal macrosomia cleft lip palat birth defect result cumul live birth signific higher compar normal bmi group differ observ among older women year multivari analysi reveal high bmi risk factor clbr studi suggest elev bmi greater advers impact younger women
|
D002971;D002972
|
T019
|
36,344,715
|
exposur famili plan messag contracept use among women reproduct age sub saharan africa cross section program impact evalu studi mani women reproduct age sub saharan africa util contracept method contribut high burden matern mortal studi determin preval trend impact exposur famili plan messag fpm contracept use cu among women reproduct age sub saharan africa ssa util recent data demograph health survey across ssa countri assess preval trend quantifi impact exposur fpm contracept use use augment invers probabl weight regress adjust sensit analysi impact estim conduct use endogen treatment effect model invers probabl weight propens score nearest neighbor match techniqu studi involv women reproduct age overal preval cu percentag women reproduct age ssa expos fpm ci ci respect exposur fpm increas cu percentag point pp ci p among women reproduct age ssa impact fpm cu highest central africa pp ci p lowest southern africa pp ci p margin declin impact estim among adolesc estim pp ci p exposur fpm contribut increas cu among women reproduct age program gear toward intensifi exposur fpm tradit media addit explor avenu promot appropri use famili plan method use electron media remain critic
|
D005193;D003270
|
T033;T121;T058;T039
|
36,344,697
|
heavi metal distribut fraction biotox sediment around villag baiyangdian lake north china effect human activ heavi metal distribut fraction sediment villag around baiyangdian lake bydl north china assess concentr cd cr cu ni pb zn sediment five villag determin potenti ecolog risk index risk assess code chironomus sp larva toxic assay use assess bioavail toxic metal contribut cd potenti ecolog risk highest among heavi metal investig contribut cd pb zn non residu fraction total concentr respect indic metal import anthropogen sourc bioavail mean risk assess code decreas order cd zn cu pb ni cr toxic cd zn biota around bydl concern mean surviv rate chironomus sp larva sediment dizhuang villag indic high degre heavi metal toxic particular waterway around villag carboxylesteras superoxid dismutas analysi result indic heavi metal could mark increas decreas enzym activ chironomus sp larva overal result indic heavi metal pollut villag around bydl taken consider ecolog manag
|
D014874;D019216
|
T131;T196
|
36,344,692
|
devis valid pen side hematolog formula hemoglobin estim cholistani cattl present studi design devis pen side hematolog formula estim hemoglobin hb pack cell volum pcv cholistani breed cattl rear pastor cholistan desert pakistan also aim valid sound rule calcul hb concentr one third pcv vice versa use human medicin cholistani cattl n bled pcv determin microhematocrit method hb estim hematolog analyz hbd well calcul one third pcv hbc independ sampl test impli deduc differ hbd hbc hbd correct hb chb studi group chb deduc regress predict equat attain linear regress model scatter plot drawn linear regress carri various studi hematolog attribut signific p posit correl coeffici notic studi group highest femal adult stock r adjust r squar hbd pcv hbd hbc regress equat overal result attain ie hb pcv use deduc chb non signific p differ notic hbd chb conclus convent human clinic medicin hb concentr third pcv vice versa impli cholistani cattl differ equat ie hb gdl pcv may provid reliabl result hb estim pcv cattl
|
D001947;D006454
|
T123;T040;T116
|
36,344,673
|
investig effect low intens visibl light human keratinocyt use custom led exposur system photobiomodul pbm refer use light modul cellular process demonstr util improv wound heal outcom reduc pain inflamm despit potenti benefit pbm precis molecular mechan influenc cell behavior yet well understood inconsist report key light paramet creat uncertainti around optim exposur profil addit low intens light jcm thorough examin use pbm present custom made compact modular led base exposur system studi effect low intens visibl light cell prolifer migrat ros product mitochondri membran potenti three differ wavelength parallel manner devic allow six repeat three differ exposur condit plus non irradi control singl well plate immortalis human keratinocyt cell line hacat select major cellular compon skin epiderm barrier furthermor vitro wound model develop allow hacat form confluent monolay scratch cell pipett tip form wound cell expos yellow nm mw mjcm orang nm mw mjcm red nm mw mjcm light min h post irradi immunohistochemistri perform evalu cell viabil prolifer ros product mitochondri membran potenti result demonstr increas prolifer decreas scratch area exposur condit howev red light increas mitochondri activ oxid stress level increas exposur present exposur system provid opportun better understand complex cellular mechan driven irradi skin cell visibl light
|
D028022
|
T061
|
36,344,671
|
integr genom proteom analysi paenibacillus peoria ibsd insight antimicrobi characterist antimicrobi resist develop fast incur loss human life need new antimicrobi agent natur occur antimicrobi peptid offer characterist counter amr resist develop low resist antimicrobi peptid paenibacillus peoria ibsd cell free supernat salt purifi use chromatographi character liquid chromatographi tandem mass spectrometri extract shown high broad spectrum antimicrobi activ combin strain ibsd genom sequenc proteom data enabl predict biosynthet gene cluster connect peptid lc msms data gene encod antimicrobi peptid databas offer platform effect search predict design amp expand studi isol structur elucid biolog evalu pathway engin genom base taxonomi comparison shown p peoria ibsd close relat paenibacillus peoria fsl j p peoria ibsd harbor endophyt trait gene nonribosom peptid synthas biosynthet gene cluster compar genom reveal evolutionari insight facilit discoveri novel sms use proteom extract p peoria ibsd increas potenti find novel bio molecul counter amr
|
D056507;D000890
|
T121;T007
|
36,344,669
|
effect moistur content evolut bacteri communiti organ matter degrad bioaugment bioga residu compost compost excel way recycl bioga residu stabl non toxic agricultur end product studi dynam chang physic chemic paramet bacteri communiti three group bioaugment compost system differ moistur content mc mc mc mc monitor differ bacteri communiti compost differ initi mc compar interact biolog non biolog paramet also explor result reveal day compost bioga residu compost mc reach highest temperatur c total kjeldahl nitrogen tkn seed germin index gi longest thermophil period durat day c addit result high throughput sequenc show divers bacteri communiti mc highest abund actinobacteria firmicut proteobacteria group highest phylum level lefs analysi indic abund ochrobactrum cellulomonadacea mc signific p higher treatment moreov canon correspond analysi cca indic thermophil period durat signific p posit correl paenibacillus besid found relat abund nocardiopsi georgenia signific p correl fertil effici compost result show control initi moistur content improv matur fertil effici compost enabl bacteria benefici compost gain advantag prolifer
|
D000076282;D039903
|
T068;T007;T167
|
36,344,664
|
organ chip model pulmonari arteri hypertens identifi bmpr sox prostacyclin signal axi pulmonari arteri hypertens pah unmet clinic need lack model human diseas key obstacl drug develop present biomimet model pulmonari arteri endotheli smooth muscl cell interact pah combin natur induc bone morphogenet protein receptor bmpr dysfunct hypoxia induc smooth muscl activ prolifer respons drug treatment bmpr oxygen specif chang endotheli smooth muscl gene express consist observ made genom biochem studi pah enabl insight under diseas pathway mechan drug respons model captur key chang pulmonari endotheli phenotyp essenti induct smc remodel includ bmpr sox prostacyclin signal axi offer easili access approach research studi pulmonari vascular remodel advanc drug develop pah
|
D000081029;D006976
|
T047;T046
|
36,344,650
|
diel vertic distribut carbon biomass zooplankton communiti carolin seamount area western tropic pacif ocean zooplankton affect regul biolog carbon pump biogeochem cycl marin ecosystem diel vertic migrat dvm behaviour diel vertic distribut migrat zooplankton communiti studi continu survey station carolin seamount area western tropic pacif ocean use multinet sampl system zooplankton speciestaxa collect identifi vertic distribut pattern abund composit zooplankton communiti differ daytim nighttim highest biodivers index occur ocean depth layer zooplankton speci remain deep water layer dvm pattern various domin speci differ even speci belong order famili dissolv oxygen seawat temperatur main environment factor affect diel vertic distribut zooplankton communiti oxygen minimum zone identifi perform dual role ecolog barrier refug zooplankton activ carbon flux mediat zooplankton dvm carolin seamount area mg c find suggest zooplankton dvm affect mediat biolog carbon pump carolin seamount area
|
D015048;D017753
|
T082;T070;T204
|
36,344,648
|
novel classif hcc base fatti acid associ lncrna aberr long noncod rna lncrna express fatti acid signal dysfunct contribut hepatocellular carcinoma hcc occurr develop howev relationship interact mechan lncrnas fatti acid signal hcc remain unclear data regard rna express clinic outcom patient hcc obtain cancer genom atlas tcga hccdb gene express omnibus geo databas hallmark pathway identifi use singl sampl gene set enrich analysi ssgsea method consensusclusterplus use establish consist matrix classifi sampl three subtyp risk signatur establish predict valu key lncrnas relat prognosi evalu use kaplan meier analysi receiv oper characterist curv estim algorithm mcp counter ssgsea use evalu characterist tumor immun microenviron ctrp prism use analyz drug sensit hcc subtyp discov seven fatti acid associ lncrnas predict prognost capabl includ trafip snhg al linc al ac abg three subtyp obtain present differ prognosi clinic inform mutat featur pathway trait immun characterist drug sensit seven key lncrnas identifi studi might serv promis biomark predict prognosi patient hcc three hcc subtyp classifi accord lncrna express profil could improv hcc classif
|
D006528;D062085;D008113
|
T123;T191;T114
|
36,344,640
|
art electron prescrib medic error common electron health record ehr reduc root creat other ehr need evolv suggest made deal prescript new titrat support process prescrib hope correct error link
|
D055695
|
T058;T170;T066
|
36,344,638
|
differ characterist retin damag chronic hypertens hypertens retinopathi purpos studi identifi chronic hypertens htn hypertens retinopathi htnr differ effect retin damag includ inner retin thin microvasculatur impair subject divid three group control htn patient without htnr htn group patient reliev htnr htnr group ganglion cell inner plexiform layer gc ipl thick vessel densiti vd gc iplvd ratio compar among group total eye enrol control group htn group htnr group mean gc ipl thick group respect p vd mm group respect p gc iplvd ratio group respect p htnr group htn durat b p systol blood pressur sbp b p signific associ gc iplvd ratio conclus inner retin reduct retin microvasculatur impair observ patient htn htnr gc iplvd ratio htnr patient signific lower htn patient indic promin damag inner retina microvasculatur htnr patient addit gc iplvd ratio signific associ sbp htnr patient strict bp control requir htnr patient
|
D058437;D012162
|
T047;T046
|
36,344,631
|
lh rc photocomplex extremophil phototroph provid insight origin two photosynthesi protein rhodopila globiformi acidophil anaerob purpl phototroph grow optim cultur ph present cryo em structur light harvest reaction center lh rc complex rhodopila globiformi resolut purpl bacteri cytochrom cyt encod gene pufc subunit associ rcs known structur n termini truncat contrast rhodopila globiformi rc contain full length tetra heme cyt n terminus embed membran form helix membran anchor comparison n termin region cyt pufx polypeptid wide distribut rhodobact speci reveal signific structur similar support longstand hypothesi pufx phylogenet relat n terminus rc bound cyt subunit common ancestor phototroph proteobacteria contain full length tetra heme cyt subunit evolv independ partial delet pufc gene eleven copi novel like polypeptid also identifi bacteriochlorophyl contain rhodopila globiformi lh complex polypeptid previous found lh bacteriochlorophyl b contain speci featur discuss relat predict function stabil lh structur regul quinon transport warm acid condit
|
D012242;D000071825
|
T007;T001
|
36,344,629
|
efficaci safeti combin mirabegron solifenacin patient doubl j stent relat overact bladder prospect studi observ efficaci safeti solifenacin andor mirabegron medic expuls therapi met patient doubl j stent relat overact bladder oab symptom total patient doubl j stent relat oab symptom prospect random two group one hundr nine case combin group accept mirabegron solifenacin therapi case control accept solifenacin therapi lower urinari tract symptom overact bladder questionnair oab q health relat qualiti life hrqol symptom bother score two group compar st nd th week end patient random assign two group patient includ combin group solifenacin group incid lut includ urgenc frequent urin incontin episod nd week vs p vs p vs p th week vs p vs p vs p combin treatment signific lower solifenacin group incid drug relat advers event solifenacin group higher combin group statist signific differ p term secondari variabl oab q hrqol score combin group statist superior comparison solifenacin group second fourth week vs p vs p oab q symptom bother score higher solifenacin group combin group vs p vs p combin therapi solifenacin mirabegron demonstr signific improv solifenacin monotherapi reduc oab symptom associ doubl j stent provid higher qualiti life without increas bothersom advers effect
|
D000069464;D053201
|
T121;T047;T109
|
36,344,628
|
impact probiot erad therapi helicobact pylori helicobact pylori h pylori well known pathogen infect approxim half world popul pathogen agent potenti health hazard relat divers diseas especi digest diseas chronic gastriti peptic ulcer gastric carcinoma clinic antibiot common appli erad therapi h pylori howev increas antibiot resist side effect induc failur erad therapi recent studi shown probiot supplement promis applic prospect restor gastrointestin microbiota balanc prevent dysbacteriosi caus antibiot furthermor report direct indirect inhibitori effect h pylori probiot may benefici effect h pylori erad howev strain dosag durat time safeti probiot supplement need studi clinic applic
|
D016480;D016481;D019936;D000069196
|
T047;T007;T001
|
36,344,626
|
learn end end high resolut lensless fiber imag toward real time cancer diagnosi recent advanc label free histolog promis new era real time diagnosi neurosurgeri deep learn use autofluoresc promis tumor classif without histochem stain process high imag resolut minim invas diagnost neglig tissu damag great import state art raster scan endoscop distal len optic limit size lensless fiber bundl endoscopi offer small diamet micron suitabl singl use probe benefici steril problem inher honeycomb artifact coher fiber bundl cfb first time demonstr end end lensless fiber imag exploit near field framework includ resolut enhanc classif network use singl shot cfb imag provid high resolut imag tumor diagnosi well train resolut enhanc network recov high resolut featur beyond physic limit cfb also help improv tumor recognit rate especi glioblastoma resolut enhanc network help increas classif accuraci novel techniqu enabl histolog real time imag lensless fiber endoscopi promis quick minim invas intraop treatment cancer diagnosi neurosurgeri
|
D019723;D009369
|
T074;T191
|
36,344,625
|
spread carpophilus truncatus razor edg outbreak pest invas southern itali campania outbreak sap beetl infest store walnut fruit monitor activ start assess spread impact pest walnut orchard warehous integr character led identifi beetl carpophilus truncatus speci europ long time rare harmless recent show also speci recent record two contin latin america australia caus massiv damag walnut almond fruit share mitochondri haplotyp among popul record three contin suggest worldwid invas might ongo geograph profil approach determin virul popul first introduc itali climat condit area c truncatus current widespread harm indic entir walnut world product jeopardi speci could adapt main walnut almond product area
|
D001517;D009036;D031324
|
T002;T204
|
36,344,623
|
develop test strip rapid detect gymnodinium catenatum harm algal bloom hab major ecolog environment problem china coastal water serious threaten stabil marin ecosystem human health gymnodinium catenatum toxic red tide dinoflagel produc paralyt shellfish toxin psp caus serious hazard marin organ public health safeti paper test strip base colloid gold immunochromatographi gicg develop rapid detect gymnodinium catenatum experiment result show test strip good specif sensit detect differ compon gymnodinium catenatum also may detect algal toxin lowest densiti gymnodinium catenatum detect test strip approxim cellsml cross reaction indic test strip high specif gymnodinium catenatum test strip provid rapid method situ detect gymnodinium catenatum refer method monitor harm alga serv earli warn upcom red tide also provid new way prepar detect method toxic algal toxin
|
D017753;D004141
|
T070;T204;T082
|
36,344,622
|
condens tannin act anthelmint increas rigid nematod cuticl tannin tannifer plant extract discuss sustain mean helminth control past two decad respons dramat increas resist toward standard anthelmint bioactiv broad investig vitro vivo less known mode action nematod apart protein bind properti current studi therefor investig impact phytochem well character plant extract combretum mucronatum known contain procyanidin activ compound model organ caenorhabd elegan differ microscop techniqu cuticl identifi main bind site tannin wherea under tissu seem affect addit disrupt cuticl structur molt defect occur larval stage final increas rigid nematod cuticl due bind tannin confirm forc spectroscop measur could key find explain sever anthelmint activ report tannin especi impair molt exsheath well locomot
|
D044945;D000871
|
T121;T109
|
36,344,620
|
incid antibiot resist genotyp vibrio speci recov select freshwat southwest nigeria vibrio speci classifi potent hazard tendenc effect serious diseas like cholera gastrointestin ailment human well vibriosi fish total freshwat sampl asept collect month across four river asejir ona dandaru erinl river month period vibrio spp isol use cultur procedur confirm mean biochem test well polymeras chain reaction pcr assay character phenotyp antibiot suscept relev antimicrobi resist determin pcr three hundr fifteen isol confirm across sampl site asejir dandaru eleyel erinl show high resist erythromycin sulphamethoxazol rifampicin doxycyclin tetracyclin amoxicillin cephalothin vari suscept antibiot multipl antibiot resist indic vibrio isol threshold limit mar phenotyp pattern e sul rf tet dox found preval pattern among isol distribut resist determin test antibiot reveal follow sulii suli sulfonamid bla oxa ampc bla pse beta lactam teta tete tet tetracyclin stra aacc apha aminoglycosid strong posit associ observ among teta suli tete sulii studi rais concern select river may contribut environment spread waterborn diseas antibiot resist gene therefor recommend environment context tailor strategi monitor surveil resist gene safeguard environ becom reservoir virul infecti vibrio speci
|
D024901;D014733
|
T032;T007
|
36,344,615
|
preval associ dri eye diseas meibomian gland dysfunct ural eye medic studi assess preval dri eye diseas ded meibomian gland dysfunct mgd popul russia popul base ural eye medic studi conduct urban rural region bashkortostanrussia includ elig person age year ded mgd assess schirmer test slit lamp base examin meibomian gland interview ded relat question studi includ individu ded mgd assess mean age year mean schirmer test result mm mm rightleft eye result mm measur confid interv ci wors eye mean subject dri eye symptom score mgd grade telangiectasia lid margin grade wors eye diagnos ci eye respect preval ded diagnosi schirmer test mm dri eye score respect dri eye score schirmer test mm mgd grade dri eye score schirmer test mm mgd grade respect mean depress score appli higher ded preval definit associ multivari analysi femal sex odd ratio ci p higher depress score ci p higher preval thyroid diseas histori ci p ded mgd common rural urban popul preval associ femal sex thyroid diseas depress
|
D000080343;D015352
|
T184;T047
|
36,344,614
|
excess volatil puzzl explain financi nois amplif endogen feedback arguabl import paradox financi econom excess volatil puzzl first identifi robert shiller state asset price fluctuat much inform fundament valu show phenomenon associ intrins propens financi market evolv toward instabl properti exemplifi two major financi market foreign exchang equiti futur market expect generic complex system excess fluctuat result interplay exogen drive endogen feedback use exact map key properti volatilityvari price diffus process onto point process arriv intens price chang togeth self excit epidem model introduc novel decomposit volatil price fluctuat exogen ie effici compon endogen ie ineffici excess compon endogen excess volatil found substanti larg stabl longer time scale thus provid plausibl explan excess volatil puzzl theori rationalis remark fact small stochast exogen fluctuat micro scale millisecond second renormalis long term excess volatil amplif factor around equiti futur exchang rate line model includ econom fundament explicit
|
D038622
|
T078;T064;T067
|
36,344,613
|
medic non adher therapeut inertia independ contribut poor diseas control cardiometabol diseas poor control cardiometabol biometr health gap measur eg uncontrol blood pressur bp hbac low densiti lipoprotein cholesterol ldl c mediat medic adher clinician level therapeut inertia ti studi compar relat contribut two factor diseas control lack conduct retrospect cohort studi use year longitudin electron health record ehr primari care cardiometabol patient year older cox regress model appli estim baselin proport day cover pdc ti associ cardiometabol relat health gap closur patient includ analysi among close bp hbac ldl c gap respect median day gap closur rang day patient retriev medic least like achiev biometr control particular ldl c hr ci ti uncertainti ti associ high risk health gap persist particular ldl c hr rang poor medic adher ti independ associ persist health gap ti much higher impact diseas control compar medic adher impli diseas manag strategi priorit reduc ti
|
D055118;D002318
|
T033;T055;T081;T047
|
36,344,612
|
formula improv reliabl optic axial length measur iol power calcul verifi influenc axial length al variat cataract surgeri iol power calcul patient underw ophthalm evalu surgeri includ optic biometri iolmast exam repeat month surgeri al oper eye evalu use two mode pseudophakicaphak option mean keratometri al chang analyz furthermor refract predict error pe back calcul barrett univers ii hoffer q holladay srkt formula elimin systemat error mean error zero formula mes median absolut error meda pes analyz two hundr one oper eye patient opposit eye evalu oper eye mean al differ mm p al measur chang cataract surgeri probabl due systemat error optic biomet case phakic eye correct factor appli preoper al could elimin systemat error iol power calcul without modifi len constant
|
D007910;D012030;D002386;D018918
|
T061;T190;T033;T047;T074
|
36,344,611
|
carcass appear influenc scaveng avoid carnivor carrion select avoid certain carrion resourc vertebr scaveng alter flow nutrient ecosystem evid suggest higher trophic level carrion scaveng fewer vertebr speci persist longer compar lower trophic level carrion although unclear scaveng distinguish carcass vari speci investig carnivor carrion avoid explor sensori recognit mechan scaveng speci investig scaveng use intact alter ie skin head feet remov coyot cani latran carnivor wild pig sus scrofa omnivor carcass experiment place savannah river site sc usa predict carnivor carcass would persist longer due conspecif intraguild scaveng avoid hypothes visual modifi carcass would reduc avoid carnivor carrion given scaveng like depend larg chemic cue assess carrion resourc expect mammalian carnivor larg avoid scaveng coyot carcass result carnivor carcass longer deplet time wild pig carcass intact alter trial therefor nutrient deriv carnivor carcass readili incorpor higher trophic level scaveng larg depend olfactori cue assess benefit risk associ vari carrion resourc
|
D046029;D002335
|
T015;T008
|
36,344,609
|
high throughput analysi tissu microarray use autom desorpt electrospray ionize mass spectrometri tissu microarray tmas common use rapid analysi larg number tissu sampl often morpholog assess increas spectroscop analysi specif molecular marker target via immunostain report use autom high throughput system base desorpt electrospray ionize desi mass spectrometri ms rapid generat onlin analysi high densiti samplesarray tmas rate better samplesecond direct open air analysi tissu sampl hundr nanogram subject prior prepar plus abil provid molecular character tandem mass spectrometri msms make experi versatil applic target untarget analysi label free manner capabl demonstr proof concept studi frozen brain tissu biopsi showcas target msms applic aim identif isocitr dehydrogenas mutat glioma sampl ii untarget ms tissu type classif use lipid profil correl tumor cell percentag estim histopatholog small sampl size larg sampl number access methodolog make power analyt system facilit identif molecular marker later use intraop applic guid precis surgeri ultim improv patient outcom
|
D021241;D005910
|
T191;T059
|
36,344,608
|
solar water disinfect larg volum contain laboratori field case studi tigray ethiopia lack safe drink water affect communiti low medium incom countri barrier overcom use sustain point use water treatment solar energi use disinfect water decad sever effort made optimis standard procedur solar water disinfect sodi process howev health impact assess implement advanc technolog field also critic step evalu success optimis work report sustain scale sodi standard l bottl l transpar jerrycan tjc month field implement four site tigray ethiopia popul live without reliabl access safe drink water whose initi baselin averag rate diarrhoeal diseas children year uva dose requir log reduct e coli alway lower minimum uva daili dose receiv tigray whm result confirm similar decreas case diarrhoea children implement l pet tjc control l pet bottl group support feasibl increas volum sodi water contain produc safer drink water sustain user friend process
|
D060766;D018508
|
T052;T167;T057
|
36,344,606
|
associ studi chromosom region q q q q number children poland number children import human trait studi indic associ singl nucleotid polymorph snps aim give evid four associ use larg sampl polish subject data popul genet databas provid anonym healthi unrel polish volunt sex n snps n studi chromosom hh invers b six q q q c random negat control zero inflat negat binomi regress zi perform number children per individu nci set non event adjustor year birth sex signific level p bonferroni correct statist signific differ data sex combin obtain high link invers snps repres rs gave mean homozygot tt nci n heterozygot ct nci n homozygot cc nci n genotyp p ttvscc p ctvscc p male data alon gave similar result recess model indic h homozygot children h homozygot heterozygot zi count estim standard error ct tt non dispers count model detect interact import signific interact age posit result obtain negat control snps b conclus associ hh invers number children previous report iceland confirm albeit use differ statist model one limit small amount data despit initi subject causal studi requir investig
|
D020641;D020022
|
T032;T086
|
36,344,604
|
silico analysi koranimin cyclic imin compound peribacillus frigoritoleran reveal potenti nematicid activ pine wilt diseas pwd destruct vector born forest diseas caus nematod bursaphelenchus xylophilus date sever option avail manag pine wilt diseas howev constant develop search natur product potenti nematicid activ imper diversifi manag option cope possibl futur emerg resist parasit nematod combin metabolom genom approach employ investig chemic repertoir biosynthet potenti bacteri endophyt peribacillus frigoritoleran previous character exhibit nematicid activ b xylophilus featur base molecular network reveal presenc divers secondari metabolit cyclic imin heptapeptid koranimin found among abund secondari metabolit produc genom mine display presenc sever putat biosynthet gene cluster bgcs includ dedic non ribosom peptid synthas nrps bgc koranimin given non ribosom peptid natur koranimin silico molecular dock analysi conduct investig potenti nematicid activ target receptor ivermectin sensit invertebr glutam gate chlorid channel glucl result reveal bind koranimin alloster site channel ivermectin bind site moreov ligand receptor interact observ most share koranimin ivermectin bound glucl receptor thus suggest possibl share mechan potenti nematicid activ studi highlight effici combin metabolom genom approach identif candid compound
|
D009348;D028223;D001406
|
T002;T204;T007
|
36,344,603
|
research maiz diseas identif method complex environ base cascad network two stage transfer learn achiev accur reliabl maiz diseas identif complex environ huge challeng diseas imag obtain natur environ often complex context may contain element similar diseas characterist symptom base cascad network two stage transform learn new method propos paper appli improv method task identif classif four maiz leaf type complex environ propos method cascad structur consist faster r cnn leaf detector denot ls rcnn cnn diseas classifi name cenet complex environ network ls rcnn detector attent mechan use detect maiz leav imag cenet model classifi leaf imag detect first stage four categori cercospora leaf spot common rust northern leaf blight healthi allow imag featur extract effici subsequ use two stage transfer learn strategi train cenet model diseas imag complex context allow faster train model ensur accuraci experiment result show propos method use identifi four type maiz leav f score better popular cnn model other method obvious advantag term train speed model propos experi posit signific explor crop varieti identif classif complex background
|
D003313;D000069550
|
T168;T066;T002
|
36,344,601
|
comparison optic qualiti vision real post lasik myopic laser surgeri simul implant phakic iol low myopia phakic intraocular len piol character wavefront aberr profil preclin studi conduct use pre post surgeri data four patient undergon myopic laser refract surgeri patient would need piol pre surgeri data use simul effect piol implant post myopic refract surgeri data use calcul post lasik eye model modul transfer function mtf point spread function psf simul optotyp vision obtain compar piol worsen optic qualiti eye evalu high order aberr alway higher post lasik eye model optic qualiti trend better piol implant post lasik surgeri pupil size increas
|
D020731;D009216;D054120
|
T061;T047;T074
|
36,344,600
|
microsatellit analysi polymorph marker develop base full length transcriptom camellia chekiangoleosa camellia chekiangoleosa popular varieti oil camellia high oil product ornament valu microsatellit ssr marker prefer tool molecular marker assist breed c chekiangoleosa focus problem low develop effici polymorph ssr marker lack avail function marker oil camellia identifi ssr loci base full length transcriptom sequenc c chekiangoleosa analysi ssr characterist show mononucleotid dinucleotid ssrs main repeat type main ssr distribut area base proport cover order follow utr utr cds compar data databas go kegg obtain function annot unigen sequenc contain ssr site data show amplif effici ssr primer develop effici polymorph ssr primer experi verifi dinucleotid pentanucleotid ssrs locat utr region could produc polymorph marker investig genet divers sever c chekiangoleosa popul also suggest develop ssr marker higher level polymorph studi provid refer high qualiti marker larg scale develop function ssr marker genet research oil camellia
|
D028244
|
T002
|
36,344,599
|
bioinformat approach identif novel deleteri mutat human tpmt valid screen molecular dynam polymorph thiopurin methyltransferas tpmt known associ leukemia inflammatori bowel diseas object present studi identifi novel deleteri missens snps tpmt comprehens silico protocol initi snp screen protocol use identifi deleteri snps pool tpmt snps dbsnp databas yield accuraci identifi extrem danger variant five novel deleteri missens snps wg wr wg lp tpmt identifi aforement screen protocol snps subject conserv analysi interact analysi oncogen phenotyp analysi structur analysi ptm analysi molecular dynam simul mds analysi assess analyz deleteri natur oncogen analysi reveal five snps oncogen mds analysi reveal snps deleteri due alter caus bind energi wild type protein plastic induc instabl caus mutat indic mds result hypothes reason alter vivo vitro protocol conclus often challeng expens henc futur research endeavor target tpmt polymorph andor consequ relev diseas progress treatment vitro vivo mean give higher prioriti snps rather consid massiv pool snps tpmt
|
D019295;D015212
|
T047;T091
|
36,344,597
|
humor immun second dose bntb vaccin japanes communiti observ cross section studi fukushima vaccin communiti survey reveal wane humor immun second dose bntb vaccin rural japanes communiti determin factor affect antibodi titer aim report immunoglobulin g igg antibodi sar cov spike protein level neutral activ larg scale communiti base cohort
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,344,593
|
extract nonlinear oper rule multi reservoir system use effici optim method hydropow plant known major renew energi sourc usual use meet energi demand peak period perform hydropow reservoir system main affect oper rule thus optim rule result higher andor reliabl energi product due complex nonlinear nonconvex multivari characterist hydropow system equat deriv oper rule system remain challeng issu multi reservoir system optim studi develop self adapt teach learn base algorithm differenti evolut satld deriv reliabl precis oper rule multi reservoir hydropow system main novelti satld enhanc teach learn mechan three signific improv rank probabl mechan introduc select learner teacher stage adapt ii teacher stage teach mechan redefin base learner performancelevel iii learner stage effect mutat oper adapt control paramet propos boost explor abil propos satld algorithm appli ten reservoir benchmark system real world hydropow system iran result illustr satld achiev superior precis reliabl method moreov result show satld increas total power generat compar advanc optim method therefor studi develop effici tool extract optim oper rule mention system
|
D000465
|
T170
|
36,344,592
|
relationship structur analysi hand clinic characterist psoriat arthriti limit inform avail possibl relationship clinic characterist miner metacarp bone finger joint space distanc jsd patient psoriat arthriti psa computer digit imag techniqu like digit x ray radiogrammetri dxr comput aid joint space analysi cajsa signific improv structur analysi hand radiograph facilit recognit radiograph damag object studi evalu clinic featur potenti influenc periarticular miner metacarp bone finger jsd psa patient patient psa underw computer measur metacarp bone miner densiti bmd dxr jsd finger joint cajsa dxr bmd jsd compar clinic featur age sex diseas durat c reactiv protein crp well treatment prednison diseas modifi antirheumat drug dmard longer diseas durat elev crp valu associ signific reduct dxr bmd wherea jsd paramet affect paramet dxr bmd signific reduc prednison group gcm prednison show impact finger jsd patient treatment bdmard present signific lower dxr bmd gcm jsd mcp cm jsd pip cm valu metacarp bmd influenc inflammatori activ prednison use dmard contrast finger jsd show chang compar baselin therapi therefor metacarp bmd well finger jsd repres radiograph destruct differ aspect
|
D015535;D001172;D018501
|
T121;T047
|
36,344,591
|
molecular co local multipl drug nanoscop deliveri vehicl potenti synergist remedi multi drug resist bacteria anti microbi resist infect predict alarm upcom year present studi propos co local two model drug viz rifampicin benzothiazol use anti tuberculosi anti fungal agent respect nanoscop cation micell cetyl triethyl ammonium bromid hydrodynam diamet nm steril effect co local micellar formul model multi drug resist bacteri strain viz methicillin resist staphylococcus aureus also investig decreas bacteri growth term coloni form unit observ use develop formul dynam light scatter forster reson energi transfer benzothiazol rifampicin show co local drug nanoscop micellar environ analysi time resolv fluoresc decay infelta tachiya model probabl distribut donor acceptor distanc fluctuat acceptor concentr confirm efficaci co local energi transfer effici donor acceptor distanc found respect also use detail comput biolog framework ration steril effect indigen formul note drug use studi use convent indic rather co local drug micellar environ show complet differ indic use remedi multi drug resist bacteria reveal purpos drug potenti use hospit born multi drug resist bacteri infect
|
D055624
|
T007
|
36,344,589
|
character four mitochondri genom superfamili noctuoidea hyblaeoidea phylogenet implic present studi newli sequenc mitogenom three noctuoid one hyblaeoid insecta lepidoptera speci annot base next generat sequenc data complet mitogenom length oraesia emarginata actinotia polyodon odontod seranensi hyblaea puera bp bp bp bp respect mitogenom found encod typic mitochondri gene protein code transfer rna ribosom rna control region similar lepidoptera speci maximum likelihood ml method bayesian infer bi use reconstruct phylogenet relationship moth studi show relationship noctuoid famili follow notodontida erebida nolida euteliida noctuida furthermor speci h puera separ cluster noctuoidea member group till speci superfamili hyblaeoidea discuss phylogenet relationship studi complet mitochondri genom one speci superfamili hyblaeoidea analys
|
D054629;D009036
|
T204;T028
|
36,344,588
|
monensin inhibit mast cell mediat airway contract human guinea pig asthma model asthma common respiratori diseas associ airway hyperrespons ahr airway inflamm mast cell mc accumul lung monensin ionophor antibiot shown induc apoptosi human mcs aim studi defin effect monensin mc respons eg antigen induc bronchoconstrict asthmat featur model allerg asthma tracheal segment hous dust mite hdm extract sensit guinea pig isol expos monensin follow histolog stain quantifi mcs guinea pig tracheal human bronchi use pharmacolog studi tissu bath system investig monensin effect tissu viabil antigen induc bronchoconstrict hdm induc guinea pig asthma model util investig effect monensin ahr airway inflamm monensin decreas mc number caus mc death block hdm anti ige induc bronchoconstrict guinea pig human airway guinea pig asthma model hdm induc ahr airway inflamm mc hyperplasia could inhibit repeat administr monensin studi indic monensin effect tool reduc mc number mcs crucial develop asthma like featur
|
D008407;D001249
|
T047;T025
|
36,344,587
|
membran damag mechan protocatechualdehyd micrococcus luteus effect pork qualiti characterist studi investig mechan membran damag protocatechualdehyd pca micrococcus luteus assess effect pca sensori physicochem properti pork mechan pca inhibit luteus studi determin minimum inhibitori concentr mic base membran potenti intracellular atp concentr intracellular ph confoc laser scan microscopi clsm field emiss gun scan electron microscopi feg sem result show mic pca luteus mgml hyperpolar bacteri cell membran decreas intracellular atp concentr intracellular ph indic pca damag cell membran luteus feg sem observ reveal pca could caus surfac collaps cell membran ruptur content outflow luteus addit pca found inhibit increas total number coloni thiobarbitur acid reactiv substanc tbar valu growth rate moistur mobil raw pork addit improv color textur raw pork effect prolong shelf life studi encourag applic pca natur antibacteri agent food industri
|
D000080305;D000069466
|
T168
|
36,344,586
|
effect fxr agonist gw treatment hilar cholangiocarcinoma rat studi object observ treatment effect farnesoid x receptor fxr agonist gw rat model hilar cholangiocarcinoma explor new therapeut target gene therapi hilar cholangiocarcinoma eighti male wistar rat random divid four group treatment group model group control group sham oper group rat group four group fed standard diet treatment group model group inject suspens cholangiocarcinoma qbc cell hilar bile duct microsyring control group inject normal salin sham oper group inject anyth modifi tail suspens test tst use evalu vital rat week one rat treatment group model group euthan chang hilar bile duct record procedur repeat week week hilar cholangiocarcinoma occur treatment group model group treatment group inject gw intraperiton dose mgkgday one week inject rat four group euthan patholog examin confirm tumour form hilar bile duct tissu taken four group fxr bsep ntcp nf b express hilar bile duct detect real time polymeras chain reaction rt pcr immunohistochemistri three week rat treatment group model group ate less weight signific reduc six week later hilar cholangiocarcinoma detect treatment group model group treatment gw ratio fxrgapdh mrna bsepgapdh mrna ntcpgapdh mrna nf bpgapdh mrna signific differ among four group light microscop fxr protein react anti fxr antibodi bsep protein react anti bsep antibodi ntcp protein react anti ntcp antibodi nf bp protein react anti nf bp antibodi show granular express everi patholog section includ cell differ number posit cell group fxr express hilar cholangiocarcinoma rat signific lower normal hilar bile duct tissu gw increas express fxr tumour tissu find suggest fxr may new therapeut target gw may help treatment hilar cholangiocarcinoma
|
D001650;D018285
|
T191
|
36,344,585
|
educ intervent base famili center empower model modifi high risk behavior brucellosi via mother educ relat contribut theori base intervent modifi high risk behavior train program major prioriti remain open question test whether famili center empower model use educ intervent effect modifi high risk behavior brucellosi via mother educ quasi experiment studi conduct women present healthcar practic rural area torbat e jam iran april februari four rural area random assign control intervent group intervent group receiv train program includ four h session consult support via social network messag servic control group receiv train spss implement test multipl statist analys find show intervent group compar control group knowledg attitud self efficaci self esteem behavior outcom signific chang p chang construct famili center empower model risk behavior control group baselin follow intervent base famili center empower model possibl accept modifi high risk behavior brucellosi increas individu knowledg chang attitud promot self efficaci self esteemtri registr iranian registri clinic trial irct irctn registr date
|
D009035;D002006
|
T092;T099;T047
|
36,344,584
|
influenti factor saliva microbiota composit oral microbiota emerg influenti factor host physiolog diseas state factor influenc oral microbiota composit well characteris particular lack popul base studi undertook larg hypothesi free studi saliva microbiota consid potenti influenti factor host health frailti diet periodont diseas demograph age sex bmi sampl process storag time sampl n twinsuk cohort adult twin alpha beta divers saliva microbiota associ strong frailti alpha divers q observ q shannon q simpson beta divers q bray curti dissimilar age alpha divers q shannon q simpson beta divers q bray curti dissimilar q weight unifrac multivari model includ age frailti sex bmi frailti diet adjust multipl test advanc age like dissimilar saliva microbiota composit younger particip p e anova subsampl analys includ consider periodont diseas total n periodont diseas n associ frailti remain alpha divers q observ asv q shannon index beta divers whilst age demonstr associ alpha beta divers subsampl potenti due insuffici statist power length time sampl store prior sequenc associ beta divers q bray curti dissimilar six bacteri taxa associ age adjust frailti diet factor studi frailti age emerg influenti regard saliva microbiota composit whilst age frailti correl associ independ give preced biolog chronolog age process potenti import consid saliva microbiota composit
|
D000073496;D064307;D010510
|
T184;T032;T033;T028;T047;T046;T001
|
36,344,583
|
increas interferon level risk sever malaria meta analysi interferon ifn contribut pathogenesi sever malaria howev mechan remain unclear herein differ ifn level patient sever uncompl malaria evalu use qualit quantit meta analysi approach systemat review protocol regist prospero id crd search relev studi perform five databas includ pubm scopus embas medlin web scienc januari juli meta analysi conduct pool mean differ md ifn level patient sever malaria uncompl malaria use random effect model dersimonian laird method overal qualit synthesi indic studi report statist signific differ ifn level patient sever malaria uncompl malaria meanwhil remain studi report ifn level signific higher patient sever malaria patient uncompl malaria one studi report ifn level signific lower patient sever malaria patient uncompl malaria meta analysi result indic patient sever malaria higher mean ifn level uncompl malaria p md pgml confid interv pgml studi studi site sever case uncompl case summari patient sever malaria exhibit higher ifn level uncompl malaria although heterogen outcom yet elucid confirm whether alter ifn level patient malaria may indic diseas sever andor poor prognosi studi warrant
|
D016778;D008288
|
T047
|
36,344,582
|
long term recoveri behavior brain tissu hydrocephalus patient shunt unpredict complex hydrocephalus shunt outcom may relat recoveri behavior brain tissu shunt simul cerebrospin fluid csf veloc intracrani pressur icp month shunt valid experiment data mean strain creep brain notabl chang shunt trend monoton highest stiff hydrocephal brain first consolid phase pre shunt month shunt viscous compon overcam damp input load third consolid phase fifteenth month chang brain volum stop long intracrani elast long ie chang oscillatori shunt linear relationship long ie icp show long term effect viscous compon brain recoveri behavior hydrocephal brain result shed light brain recoveri mechan shunt mechan shunt failur
|
D002557;D006849
|
T061;T019;T047;T033
|
36,344,581
|
probabilist model check cancer metabol cancer cell metabol often deregul result adapt meet energi biosynthesi demand rapid growth direct mutat key metabol enzym better understand deregul provid new insight target vulner complic difficulti probe cell metabol differ level resolut differ experiment condit construct comput model glucos glutamin metabol focus effect idh mutat cancer use combin experiment metabol flux data patient deriv gene express data model demonstr potenti comput explor reveal biolog behavior show exogen mutat idh experiment model util glutamin altern carbon sourc lactat product hypoxia fulli recapitul patient phenotyp normoxia also demonstr util use gene express data proxi relat differ metabol activ use approach probabilist model check freeli avail probabilist symbol model checker construct reason model behavior
|
D005973;D009369
|
T123;T121;T191;T116
|
36,344,580
|
machin learn base person drug respons predict lung cancer patient lung cancer mutat epiderm growth factor receptor egfr major contributor cancer fatal global target tyrosin kinas inhibitor tkis develop egfr show encourag result surviv rate qualiti life howev drug resist may affect treatment plan treatment efficaci may lost year predict respons egfr tkis egfr mutat lung cancer patient key research area studi propos person drug respons predict model pdrp base molecular dynam simul machin learn predict respons first generat fda approv small molecul egfr tkis gefitiniberlotinib lung cancer patient patient mutat status taken consider molecular dynam md simul patient uniqu mutat status model consid md simul extract molecular level geometr featur moreov addit clinic featur incorpor machin learn model drug respons predict complet featur set includ demograph clinic inform dci geometr properti drug target bind site bind free energi drug target complex md simul pdrp incorpor xgboost classifi achiev state art perform accuraci recal precis f score class drug respons predict task found model geometri bind pocket combin bind free energi good predictor drug respons howev observ clinic inform littl impact perform model propos model could test type cancer believ pdrp support plan effect treatment regim base clinic genom inform sourc code relat file avail github https githubcomrizwanqureshipdrp
|
D002289;D008175
|
T191
|
36,344,577
|
develop sand plastic composit floor tile use silica sand recycl thermoplast sustain approach cleaner product strict environment concern deplet natur recours rise demand build construct materi promot scientif research toward altern build materi research support idea sustain circular economi via util wast produc valu ad product research explor potenti wast plastic silica sand develop thermoplast composit floor tile sampl character water absorpt compress strength flexur strength slide wear morpholog analysi sand plastic interfac cover umbrella studi maximum compress flexur strength found nmm nmm respect minimum water absorpt slide wear rate kgm respect studi suggest workabl develop floor tile non traffic area public place thus studi provid green build materi recycl wast plastic sustain develop
|
D010969;D000080463
|
T197;T167
|
36,344,576
|
improv signal nois ratio fluoresc imag microfluid chip microfluid system fabric various way use origin silicon glass system easi si process surfac modif subsequ applic cell seed studi fluoresc imag cell becam standard techniqu investig cell behavior unfortun high sensit fluoresc imag eg use total intern reflect fluoresc tirf microscopi problemat microfluid system uneven surfac silicon channel bottom affect light penetr optic filter work studi natur phenomenon find problem rectifi use silicon insul soi substrat defin channel depth thick top si layer halt etch buri sio layer fluoresc background signal drop time correspond limit detect drop mm nm fluorescein demonstr import flat surfac use tirf base singl molecul detect improv signal nois ratio time compar convent si wafer overal use high qualiti soi substrat pay improv fluoresc imag qualiti due increas signal nois ratio concern cost microfluid devic fabric design mask fabric wafer process devic test initi soi wafer cost margin use improv system perform
|
D044085;D012825
|
T090;T196
|
36,344,575
|
novel punctur approach via point percutan kyphoplasti patient l l osteoporot vertebr compress fractur studi introduc novel point punctur approach percutan kyphoplasti pkp patient l l osteoporot vertebr compress fractur ovcf evalu clinic radiograph outcom septemb decemb compar clinic radiograph outcom case vertebra use entri point pkp intervent pkp case vertebra use transvers process pedicl approach pkp intervent pkp serious postop complic observ particip two pkp patient experienc intervertebr disc space leakag compar pkp patient pkp patient show shorter oper time fluoroscopi time p improv vas odi score final follow p better increas vertebr compress ratio p compar anteroposterior bone cement distribut enhanc bilater bone cement distribut p larger sagitt transvers angl p herein pkp indic patient l l ovcf punctur approach show signific advantag pkp term pain relief surgeri fluoroscopi time also punctur angl vertebr reconstruct symmetr cement distribut
|
D058498;D050815;D016103;D058866
|
T061;T047;T046;T037
|
36,344,573
|
role task demand racial face encod peopl accur rememb face racial group compar face racial group phenomenon call race effect date numer research devot explor reason race effect posit sever theoret explan one integr explan categor individu model address two primari way categor individu racial face process emphas emerg two way encod stage learn recognit racial categor task two classic task use explor racial face process event relat potenti facilit investig encod differ race face two typic task demand unfortun date result mix current studi investig whether categor individu differ race face encod stage use racial categor learn recognit task found task demand influenc encod racial face also profound effect encod stage recognit task race face specif race face demonstr deeper structur encod race face less attent involv moreov recognit task might ask individu level encod requir attent resourc earli stage may maintain relat late stage result provid evid concern task select futur racial face studi establish groundwork unifi interpret racial face encod
|
D044465;D000066499
|
T098;T041
|
36,344,571
|
biosynthesi gamma aminobutyr acid lactiplantibacillus plantarum k altern revalu agri food product probiot metabolit known postbiot receiv attent due wide varieti promot health effect one excit postbiot gamma aminobutyr acid gaba wide produc lactic acid bacteria due benefit health addit perform biosynthesi gaba lactiplantibacillus plantarum could modul modif ferment paramet due high nutrit valu agri food product could consid use ferment sourc microorgan therefor product propos ferment substrat produc gaba studi previous sever experi man rogosa sharp mrs broth perform identifi critic paramet produc gaba use strain lactiplantibacillus plantarum k percentag inoculum initi ph concentr nutrient monosodium glutam glucos signific affect biosynthet pathway gaba highest gaba yield obtain mm monosodium glutam gl glucos initi ph inoculum furthermor investig paramet use evalu possibl use tomato green pepper appl orang product get gaba enrich ferment media excel way revaloris
|
D012970;D048191
|
T121;T168;T116;T007
|
36,344,570
|
sharp wave rippl doublet induc complex dendrit spike parvalbumin interneuron vivo neuron plastic shown causal link coincid detect dendrit spike dspike demonstr exist spw r associ branch specif local dspike comput role basal dendrit hippocamp pv interneuron awak anim measur entir dendrit arbor long thin dendrit spw rs use fast acousto optic imag eccentr deep brain adapt ipsilater local field potenti record regen calcium spike start variabl nmda ampa depend hot spot propag direct high amplitud beyond critic distanc threshold involv voltag gate calcium channel supralinear dendrit summat emerg spw r doublet two success spw r event coincid within short tempor window ms eg complex associ task generat larg dspike fold amplitud increas propag soma result suggest doublet associ dspike work dendrit level tempor spatial coincid detector spw r relat network comput awak mice
|
D010320;D007395
|
T123;T116;T025
|
36,344,569
|
differ water vapor transport angstrom scale pore atom thin membran transport water nanoscal capillariespor play promin role biolog ionicmolecular separ water treatment protect applic howev mechan water vapor transport nanoscal confin remain fulli understood angstrom scale pore introduc atom thin graphen lattic repres ideal model system probe water transport molecular length scale short pore aspect ratio ie pore diamet approach pore length theoret limit materi thick report order magnitud differ transport water vapor g day pa liquid water g day pa nanopor diamet monolay graphen ration differ via flow resist model liquid water permeat occur near continuum regim wherea water vapor transport occur free molecular flow regim demonstr centimet scale atom thin graphen membran order magnitud higher water vapor transport rate g day commerci avail ultra breathabl protect materi effect block even sub nanomet nm model ionsmolecul
|
D006108;D058608
|
T196;T082;T109
|
36,344,568
|
children percept interperson coordin joint paint interperson coordin import mani joint activ special case interperson coordin synchron requir perform mani activ also associ divers posit social emot attribut extent effect due relianc synchroni task perform specif rhythmic characterist clear address question consid general form interperson coordin implement joint artmak non typic context interperson coordin requir task success smoother loos structur standard form synchron coordin therefor compar interperson coordin non coordin share paint could help reveal general social emot reaction coordin gain nave perspect focus children stage coordin non coordin art interact adult child ask child observ judg various variabl reflect perceiv bond painter found overal stronger perceiv bond coordin condit result demonstr even non typic form interperson coordin could attribut posit social emot qualiti capac reveal alreadi childhood possibl implic develop
|
D007398;D013647
|
T061;T080;T055;T054;T057
|
36,344,567
|
multi scale organ communic activ matter emerg collect motion among interact self propel agent central paradigm non equilibrium physic exampl activ matter rang swim bacteria cytoskelet motil assay synthet self propel colloid swarm microrobot remark aggreg capabl mani system reli theme fundament ubiquit natur communic despit emin import role communic collect organ activ system yet fulli understood report multi scale self organ interact self propel agent local process inform transmit chemic signal show communic capac dramat expand abil form complex structur allow self organ seri collect dynam state multipl hierarch level find provid insight role self sustain signal process self organ biolog system open rout applic use chemic driven colloid microrobot
|
D003102;D010825
|
T090;T122
|
36,344,566
|
gustatori function sensilla chaetica labial palp antenna three tortricid moth lepidoptera tortricida adult lepidoptera labial palp best known role co detect also bear sensilla chaetica function unknown number distribut sensilla chaetica labial palp studi use bright field microscop determin sensilla gustatori function perform singl sensillum electrophysiolog record palp antenn sensilla adult moth cydia pomonella l grapholita molesta busck lobesia botrana deni shiefferml sensillum stimul dose one four test stimulus sucros fructos kcl nacl overal respons spikess increas dose higher palp antenna higher sugar salt sugar respons increas concentr palp antenna salt drop respons intermedi concentr number posit sensilla chaetica labial palp variabl among individu sensilla locat expos area palp differ sensilla distribut detect speci differ among speci palp antenna suggest tast sensilla palp unforeseen role adapt
|
D058618;D009036
|
T023;T204
|
36,344,565
|
structur basi organ cation transport inhibit organ cation transport oct facilit transloc catecholamin drug xenobiot across plasma membran various tissu throughout human bodi oct play key role low affin high capac uptak monoamin tissu includ heart brain liver deregul play role diseas despit import structur basi oct function inhibit remain enigmat describ cryo em structur human oct resolut structur oct bound two inhibitor corticosteron decynium defin ligand bind pocket reveal common featur major facilit transport inhibitor addit relat function characterist extens collect previous uncharacter human genet variant structur featur therebi provid basi understand impact oct polymorph
|
D027701;D003345
|
T123;T121;T116;T109;T125
|
36,344,564
|
correl domain specif sedentari behavior object assess sedentari time among elementari school children understand correl sedentari behavior among children essenti develop effect intervent reduc sit time vulner popul studi aim identifi correl domain specif sedentari behavior object assess sedentari time among sampl children japan data children age year live japan use domain specif sedentari behavior assess use questionnair total sedentari time estim use hip worn acceleromet twenti two potenti correl across five categori parent characterist household indoor environ residenti neighborhood environ school environ school neighborhood environ includ multivari linear regress model use identifi correl domain specif sedentari behavior object assess sedentari time eight correl signific associ children domain specif sedentari behavior mother father age mother educ level videodvd recorderplay video consol tv one room home walk score pedestriancycl safeti signific associ found potenti correl acceleromet base total sedentari time find highlight strategi reduc children sedentari time consid context behavior exampl urban design attribut perceiv pedestrian cycl safeti improv reduc children car sit time
|
D057185;D015444
|
T033;T056;T079;T061
|
36,344,563
|
epifluid electron patch spike sweat clearanc event driven perspir monitor sensori neuron generat spike pattern upon receiv extern stimuli encod key inform spike pattern enabl energi effici extern inform process herein report epifluid electron patch spike sweat clearanc use sensor contain vertic sweat collect channel event driven energi effici long term wireless monitor epiderm perspir dynam sweat sensor contain nanomesh electrod inner wall channel uniqu sweat clear structur perspir repeat fill abrupt empti vertic sweat collect channel generat electr spike pattern sweat rate ionic conduct proport spike frequenc amplitud wide dynam rang long time h spike sweat clearanc correspond electron spike pattern epifluid wireless patch success decod epiderm perspir dynam event driven manner differ skin locat exercis consum less energi requir continu data transmiss patch could integr various skin sensor emerg edg comput technolog energi effici intellig digit healthcar
|
D013542;D015374
|
T059;T075;T031
|
36,344,562
|
femal bone physiolog resili past polynesian outlier communiti remodel fundament biolog process involv mainten bone physiolog function know rang health lifestyl factor impact process live past societi notabl gap bone remodel data popul pacif island conduct first examin femor cortic histolog individu ca bp taumako solomon island remot polynesian outlier island melanesia test whether bone remodel indic differ age group biolog sex valid use ancient dna bone vascular canal osteon size vascular poros localis osteon densiti correct femor robust indic examin femal statist signific higher vascular poros compar male osteon densiti ratio canal osteon differ sex result indic compar male localis femor bone tissu taumako femal drastic declin age contrari often observ modern popul howev result match find archaeolog sampl testament past femal bone physiolog resili also observ pacif region
|
D006253;D005269
|
T023;T024;T030
|
36,344,561
|
circuit guid popul acclim synthet microbi consortium improv biochem product microbi consortia consid potenti platform bioprocess applic howev complex process control owe use multipl strain necessit use effici popul control strategi herein report circuit guid synthet acclim strategi improv biochem product microbi consortium design consortium compris algin util vibrio sp dhg hydroxypropion acid hp produc escherichia coli strain direct convers algin hp introduc genet circuit name popul guider e coli strain degrad ampicillin hp produc presenc ampicillin select pressur consortium success acclim increas hp product fold compar simpl co cultur consortium h ferment believ concept use strategi develop robust consortium base bioprocess
|
D059013;D004926
|
T007;T001
|
36,344,560
|
factor influenc lion movement habitat use western serengeti ecosystem tanzania protect area restrict human activ enhanc wildlif habitat qualiti efficaci protect area improv increas protect illeg activ presenc buffer protect area surround core protect area habitat valu protect area also affect season variat anthropogen pressur examin season space use african lion panthera leo within core protect area serengeti nation park tanzania surround buffer protect area vari protect strength use lion locat logist regress model wet dri season estim probabl use relat protect strength distanc protect area edg human livestock densiti distanc road river land cover lion use strong protect buffer area core protect area unprotect area move away protect area boundari toward core protect area buffer protect area less protect lion avoid high livestock densiti wet season high human densiti dri season increas strength protect decreas edg effect buffer area help maintain habitat qualiti core protect area lion wildlif speci
|
D008045
|
T015
|
36,344,559
|
bayesian deep learn error estim analysi anomal diffus modern singl particl track techniqu produc extens time seri diffus motion wide varieti system singl molecul motion live cell movement ecolog quest deciph physic mechan encod data thus better understand probe system augment recent propos machin learn techniqu decod anomal diffus data includ uncertainti estim addit predict output avoid black box problem bayesian deep learn techniqu name stochast weight averag gaussian use train model classif diffus model regress anomal diffus expon singl particl trajectori evalu perform find model achiev well calibr error estim maintain high predict accuraci analysi output uncertainti predict relat properti under diffus model thus provid insight learn process machin relev output
|
D000077321
|
T066
|
36,344,558
|
compar pangenom analysi genus streptomyc streptomycet high metabol gift bacteria abil produc bioproduct profound econom societ import bioproduct produc metabol pathway includ biosynthesi secondari metabolit catabol plant biomass constitu advanc genom sequenc technolog reveal wealth untap metabol potenti streptomyc genom report largest streptomyc pangenom generat use complet genom metabol potenti pangenom individu genom analyz reveal degre conserv individu metabol pathway strain potenti suitabl metabol engin streptomyc bingchenggensi identifi potent degrad plant biomass polyketid non ribosom peptid gamma butyrolacton biosynthet enzym primarili strain specif ectoin terpen biosynthet pathway high conserv larg number transcript factor associ secondari metabol strain specif control basic biolog process high conserv although major gene involv morpholog develop high conserv strain specif varieti may contribut fine tune time cellular differenti overal result provid insight metabol potenti regul physiolog streptomycet facilit exploit import bacteria
|
D013302;D061065
|
T121;T007;T109
|
36,344,556
|
nogo receptor ngr novel v integrin effector induc neuroendocrin differenti prostat cancer androgen depriv therapi aim target prostat cancer prca partial success given occurr neuroendocrin prca neprca high aggress high metastat form prca effect therapeut approach group demonstr absent prostat adenocarcinoma v integrin express increas prca progress toward neprca show novel pathway activ v promot ne differenti ned novel pathway requir express gpi link surfac molecul ngr also known nogo receptor homolog show ngr upregul v associ also show promot ned anchorag independ growth well motil phenotyp prca cell given observ high level v shown ngr detect human mous neprca find appear high relev aggress metastat subtyp prca studi novel ngr role minim investig cancer instead predomin analyz neuron data thus pave new avenu toward comprehens mechanist understand integrin direct signal prca progress toward ne phenotyp
|
D011471;D018278
|
T191
|
36,344,555
|
genom control inflamm experiment atop dermat atop dermat ad eczema recurr allerg inflamm skin afflict children adult racial ethnic group global report new topic treatment ad nuclear transport checkpoint inhibitor ntci target two nuclear transport shuttl importin importin preclin model ad induc activ vitamin analog mc calcipotriol ntci suppress express keratinocyt deriv cytokin thymic stromal lymphopoietin tslp key gene ad develop moreov gene encod mediat h respons il receptor il r also silenc togeth gene encod cytokin il il il il il ifn gm csf vegf chemokin rant il intracellular signal transduc cox ino consequ ntci suppress skin infiltr inflammatori cell eosinophil macrophag cd lymphocyt reduc mc evok prolifer ki posit cell thus highlight mechan action potenti util topic ntci treatment ad undergo phase clinic trial amtx cf nct
|
D003876
|
T047
|
36,344,554
|
sperm tendenc agglutin motil bundl relat sperm competit fertil durat chicken uniqu sperm behavior observ egyptian chicken sperm show tendenc agglutin form motil thread like bundl sperm agglutin behavior kinemat morphometr measur studi relat sperm competit fertil durat sharkasi dandarawi chicken sperm tendenc agglutin assess examin sperm morpholog use scan electron microscopi acridin orang stain semen smear use fluoresc microscopi record video sperm phase contrast microscop sperm veloc morphometr measur evalu use imag j softwar assess sperm competit sharkasi dandarawi hen artifici insemin semen pool possess equal number sharaksi dandarawi sperm artifici insemin repeat ten time egg obtain incub hatchl discrimin descend sharkasi dandarawi father accord phenotyp assess fertil durat sharkasi dandarawi hen insemin semen collect rooster strain egg collect period day post insemin incub sharkasi spermatozoa show higher tendenc agglutin form longer thicker motil bundl signific differ observ sperm curvilinear straight line veloc sperm morphometr measur sharkasi dandarawi chicken sharkasi rooster father hatchl produc sharkasi dandarawi mother respect fertil period sharkasi dandarawi day respect suggest differ seen sperm competit fertil durat attribut sperm agglutin behavior
|
D002645;D012661
|
T012;T031
|
36,344,553
|
muc vntr polymorph associ bronchial asthma egyptian children overproduct mucin airway donat larg airway blockag asthma patient glycoprotein muc play role clearanc bacteria anti candidacid criteria goal investig associ muc variabl number tandem repeat vntr polymorph bronchial asthma among egyptian children muc vntr polymorph investig among children bronchial asthma healthi control use polymeras chain reaction pcr method serum level immunoglobulin e ige tumor necrosi factor alpha tnf transform growth factor beta tgf assess enzym link immunosorb assay elisa techniqu frequenc genotyp genotyp genotyp muc allel muc vntr variant signific lower among asthmat patient control p ci p ci p ci p ci respect genotyp muc vntr variant associ clinic manifest serum level ige tnf tgf among asthmat patient p conclus genotyp muc vntr variant may protect role bronchial asthma egyptian children
|
D011110;D001249
|
T045;T047
|
36,344,551
|
character bacteri divers two coastal region heterogen soil textur studi microbi divers effect extern factor microbiom could expand understand environment alter silt sand miner particl form soil textur even though soil earth contain fraction soil form almost effect microbiom remain elucid studi bacteri biodivers sand silt clay soil investig furthermor effect plant growth determin data show biodivers biomass microbiom higher silt base soil interest pseudomona genera exist silt base soil absenc sand base soil contrast b thuringiensi could found sand base soil found silt textur data also demonstr signific chang stress respons two group howev differenti physiolog chang plant inocul silt sand base bacteri isol observ data could indic smaller size particl could contain bacteria higher biodivers due provid surfac bacteria grow
|
D012987;D012988
|
T067;T167
|
36,344,549
|
threat learn impair subsequ associ infer despit wide acknowledg import function memori facilit predict signific event complex world studi date investig abil infer associ across distinct overlap experi affect inclus threat memori address question particip n encod neutral predict associ b follow day memori reactiv pair b new avers neutral outcom b c threatneutr pupil dilat measur index emot arous day later accuraci indirect associ c test associ infer involv threat learn memori impair wherea initi memori retroact strengthen effect moder pupil dilat encod result impli healthi memori system may compartment episod inform threat hinder recal cu indirect malfunct process may caus maladapt linkag negat event distant benign memori therebi contribut develop clinic intrus anxieti
|
D011939;D007858
|
T062;T041;T061
|
36,344,547
|
impact bodi mass index hospit mortal six acut cardiovascular diseas japan bodi mass index bmi distribut impact cardiovascular diseas cvd vari asian western popul studi aim reveal time relat trend preval obes underweight safe rang bmi japanes patient cvd analyz record nation japanes registri cardiac vascular diseas diagnosi procedur combin dataset time evalu bmi trend impact hospit mortal six acut cvds acut heart failur ahf acut myocardi infarct ami acut aortic dissect aad ischem stroke intracerebr hemorrhag ich subarachnoid hemorrhag sah patient categor five group use asian bmi criteria underweight kgm normal kgm overweight risk kgm obes kgm obes ii kgm age signific invers relat high bmi diseas p proport bmi categori signific alter time annual bmi trend show signific gradual increas except aad adjust mix model underweight signific associ high risk hospit mortal cvd patient ahf ci p ami ci p aad ci p ci p ich ci p sah ci p moreov obes ii group signific associ higher incid hospit mortal except ahf age associ hospit mortal bmi categori six cvd patient bmi increas annual patient six type cvds although underweight bmi associ high mortal rate impact obes hospit mortal differ among cvd type
|
D002318;D009203;D006333
|
T047;T046
|
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