PMID
int64 35.7M
36.4M
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36,296,397
|
alzheim diseas major public health concern role dietari saponin mitig neurodegen disord under mechan saponin triterpenoid steroid glycosid import group natur occur compound plant origin exhibit divers pharmacolog potenti includ radic scaveng well neuroprotect anti diabet anti inflammatori activ owe divers chemic scaffold saponin consist aglycon part non sugar glycon part sugar least one glycosid c sugar bond linkag present glycon aglycon most c basi aglycon part saponin classifi triterpenoid glycosid steroid glycosid alkaloid glycosid saponin exhibit neuroprotect activ various disord central nervous system cns includ stroke alzheim diseas ad huntington diseas hd parkinson diseas pd mediat therapeut effect modul various patholog target studi highlight various neuroprotect mechan saponin includ free radic scaveng modul neuroprotect signal pathway activ neurotroph factor modul neurotransmitt inhibit bace enzym tau hyper phosphoryl studi conclud saponin consider efficaci various patholog target neurolog disord especi ad might import sourc lead neurodegen disord
|
D012503;D000544;D019636;D014315
|
T047;T048;T109
|
36,296,396
|
authent iranian saffron crocus sativus use stabl isotop c h metabolit quantif saffron high valu ad ingredi use food supplement market contain high level safran ad synthet safran saffron signific cheaper falsifi origin saffron may repres recurr fraud saffron differ countri analyz determin stabl isotop ratio c h safran gas chromatographi coupl isotop ratio mass spectrometri gc cp irm concentr saffron metabolit ultra high perform liquid chromatographi coupl diod array detector uhplc dad isotop analysi highlight higher ratio h synthet safran natur safran mean valu respect c iranian spanish saffron signific differ repres median valu respect moreov linear quadrat discrimin analys lda qda comput use two isotop ratio safran saffron metabolit first qda show tran crocetin c safran picrocrocin crocin c concentr clear differenti iranian saffron origin second model identifi c tran crocetin crocin c crocin c picrocrocin good predictor discrimin saffron sampl iran spain origin total abil score classif matrix predict matrix combin approach may use tool authent origin unknown saffron
|
D027622
|
T002
|
36,296,394
|
advanc phenoxypyridin activ scaffold pesticid phenoxypyridin bioisoster diaryl ether wide introduc bioactiv molecul activ scaffold differ properti diaryl ether paper bioactiv structur activ relationship mechan compound contain phenoxypyridin summar may help explor lead compound discov novel pesticid potenti bioactiv
|
D010575
|
T131
|
36,296,392
|
prepar character magnet metal organ framework function ionic liquid support immobil pancreat lipas enzym difficult recycl limit larg scale industri applic work ionic liquid modifi magnet metal organ framework composit il fe uio nh prepar use support enzym immobil properti support character x ray powder diffract xrd fourier transform infrar ftir spectra transmiss electron microscopi tem scan electron microscopi sem catalyt perform immobil enzym also investig hydrolysi reaction glyceryl triacet compar solubl porcin pancreat lipas ppl immobil lipas ppl il fe uio nh greater catalyt activ reaction condit also show better thermal stabil anti denatur properti specif activ ppl il fe uio nh time higher solubl ppl repeat catalyt cycl residu activ ppl il fe uio nh reach higher ppl fe uio nh addit kinet paramet test reveal ppl il fe uio nh stronger affin substrat thus exhibit higher catalyt effici result demonstr fe uio nh modifi ionic liquid great potenti immobil enzym
|
D052578;D000073396
|
T120;T103;T109
|
36,296,391
|
stab resist perform well engin soft bodi armor materi use shear thicken fluid stab resist bodi armor effect prevent sharp instrument attack protect part reduc threat human bodi shear thicken fluid stf kind smart materi variabl viscos viscos chang signific extern stimuli soft adapt characterist stf provid new idea improv perform stab proof materi work three kind soft anti stab materi design prepar aramid poli p phenylen benzodioxazol pbo carbon fiber fabric impregn stf quasi static punctur test dynam impact test conduct compar perform differ anti stab structur result show peak pierc forc stf treat fabric punctur test great increas neat sampl knife maximum impact load stfpbo fiber fabric increas n n increas spike maximum impact load stfaramid fabric increas n n increas mechan properti fiber import factor resist knive fabric structur key point bear spike optic photograph fabric fractur scan electron microscop analysi indic stf effect limit slip fiber bundl tool penetr fabric play posit role maintain tight integr fabric structur
|
D018594;D000080745
|
T023;T016;T073
|
36,296,390
|
effect chitosan amphiphil polym photosensit spectral properti rose bengal influenc chitosan cs amphiphil polym ap pluron f polyvinylpyrrolidon pvp photocatalyt activ rose bengal rb model reaction tryptophan photo oxid phosphat buffer salin pbs studi shown presenc cs effect rate constant k eff tryptophan photo oxid catalyz rb pbs solut decreas factor two due ionic interact rb chitosan rose bengal slight acid environ ph pass neutral lacton form sharpli reduc photosensit properti dye demonstr introduct ap solut contain rb cs prevent direct interact rb cs evidenc presenc photocatalyt activ dye rb ap cs system well bathochrom shift main absorpt band dye increas optic densiti luminesc intens rb ap introduc buffer solut contain rb chitosan presenc rb cs rb ap interact aqueous pbs media confirm increas degre fluoresc anisotropi r binari system aqueous solut valu r rb f cs system decreas factor compar valu r rb cs system associ local dye pluron micell pbs fluoresc anisotropi practic system relat stabil dye structur medium presenc interact rb ap aqueous solut confirm proton nmr method addit format rb f macromolecular complex form associ solut concentr particular evapor shown afm rb ap cs system may promis practic applic treatment local foci infect apdt
|
D012395;D048271
|
T121;T130;T109
|
36,296,389
|
recent synthet biolog approach temperatur light control gene express bacteri host express gene interest goi initi provid extern stimuli temperatur shift light irradi applic thermal light stimuli trigger structur chang stimuli sensit biomolecul within cell therebi induc repress gene express past two decad sever group report genet circuit use natur engin stimuli sensit modul manipul gene express summar versatil strategi thermosensor light driven system condit express goi bacteri host
|
D058615;D053263
|
T090;T044
|
36,296,388
|
advanc fungal phenaloenon natur metabolit great promis biosynthesi bioactiv silico evalu potenti human glucos transport inhibitor phenaloenon structur uniqu aromat polyketid report microbi plant sourc possess hydroxi perinaphthenon three fuse ring system exhibit divers bioactiv cytotox antimicrobi antioxid anti hiv properti tyrosinas glucosidas lipas ach acetylcholinesteras indoleamin dioxygenas angiotensin convert enzym tyrosin phosphatas inhibit moreov rich nucleophil nucleus inspir mani chemist biologist synthes relat deriv current review provid overview report phenalenon fungal origin includ structur sourc biosynthesi bioactiv moreov metabolit list refer cite superpr artifici intellig ai webserv use predict potenti target select phenalenon among target chose human glucos transport hglut extens silico studi show high probabl model accuraci among aspergillussanon c g possess highest negat dock score kcalmol respect compar nativ inhibitor score kcalmol md molecular dynam simul reveal stabil complex glut ns virtual screen studi result open new therapeut approach use phenalenon hglut inhibitor might potenti target cancer therapi
|
D000110;D061065
|
T121;T126;T116;T109
|
36,296,387
|
preprocess nir spectra aquaphotom even though nir spectroscopi base beer lambert law clear relat concentr absorb element absorb measur spectra subject spurious signal addit multipl effect use nir spectra therefor requir preprocess step articl review main preprocess method light aquaphotom simpl method visual spectra propos order guid user choic best preprocess common chemometr preprocess present illustr three real dataset preprocess aim produc spectrum close possibl absorb would measur ideal condit use establish aquagram other dedic improv resolut spectra use identif peak final special attent given problem reduc multipl effect potenti pitfal popular method chemometr altern propos recent paper present
|
D019265
|
T059
|
36,296,386
|
isobavachalcon induc multipl cell death human tripl negat breast cancer mda mb cell standard treatment guidelin effect drug avail human tripl negat breast cancer tnbc mani effort recent exert investig efficaci natur compound anticanc agent owe low toxic howev studi examin effect isobavachalcon ibc program cell death pcd human tripl negat breast mda mb cancer cell studi ibc substanti inhibit prolifer mda mb cell concentr time depend manner addit found ibc induc multipl cell death process apoptosi necroptosi autophagi mda mb cell initi mechan ibc mediat cell death mda mb cell involv downregul akt p akt increas baxbcl ratio cleav caspas induc apoptosi upregul rip p rip mlkl induc necroptosi well simultan increas lc iii ratio induc autophagi addit observ ibc induc mitochondri dysfunct therebi decreas cellular atp level increas reactiv oxygen speci accumul induc pcd result suggest ibc promis lead compound anti tnbc activ
|
D064726;D000970
|
T121;T191;T109
|
36,296,385
|
optim lipid extract spirulina spp ultrasound applic mechan stir use taguchi method experiment design present studi use taguchi method experiment design optim lipid extract spirulina spp ultrasound applic mechan stir taguchi l orthogon array use optim various paramet methanol chloroform c ratio biomass solvent ratio extract time lipid extract result analyz use signal nois n ratio analysi varianc anova biomass solvent ratio signific influenc lipid content p lt contribut lipid n ratio data respect extract time present contribut valu c ratio present neglig contribut n data optimum extract condit c ratio biomass solvent ratio extract time min predomin fatti acid palmit acid linol acid gamma linolen acid confirm experi indic lipid content within confid interv prove taguchi method effect optim process paramet lipid extract
|
D000432;D053545
|
T131;T007;T130;T109
|
36,296,383
|
select format unsymmetr multident azin base ligand nickel ii complex mixtur pyridin carboxaldehyd formylimidazol methyl formylimidazol nicl h molar ratio react two equival hydrazin monohydr methanol follow addit aqueous nh pf solut afford ni ii complex two unsymmetr azin base ligand ni hl h pf ni hl pf high yield hl h denot pyridylmethylidenehydrazono imidazolyl methan hl methyl imidazolyl deriv spectroscop measur element analysi confirm phase puriti bulk product singl crystal x ray analysi reveal molecular crystal structur ni ii complex bear unsymmetr hl h hl azin trident n n n coordin mode hl h complex methanol solvent meoh crystal orthorhomb non centrosymmetr space group p z afford conglomer crystal hl complex h oet crystal monoclin centrosymmetr space group p n z crystal h oet intermolecular hydrogen bond interact imidazol n h neighbor uncoordin azin n atom form one dimension polymer structur obvious magnet interact among intra interchain paramagnet ni ii ion
|
D009532;D000432
|
T123;T109;T131;T196;T130
|
36,296,382
|
comprehens comparison two color varieti perilla folium gc ms base metabolom approach perilla folium pf leaf perilla frutescen l britt extens use culinari veget mani countri divid two major variet form base leaf color variat includ purpl pf perilla frutescen var arguta green pf p frutescen var frutescen aroma purpl green pf discrep figur diverg chemic composit purpl green pf gas chromatographi tandem mass spectrometri gc ms appli analyz compound purpl green pf total compound identifi relat quantifi multivari statist method includ princip compon analysi pca orthogon partial least squar discrimin analysi opl da cluster analysi ca use screen chemic marker discrimin purpl green pf seven compound accumul discrep green purpl pf character chemic marker discrimin purpl green pf among marker compound limonen shisool perillaldehyd branch terpenoid biosynthet pathway relat higher content purpl pf perilla keton isoegomaketon tocopheryl squalen branch pathway higher green pf result present studi expect provid theoret support develop util pf resourc
|
D013185;D031344
|
T121;T130;T002;T109
|
36,296,381
|
pet oncolog radiopharmaceut current status perspect molecular imag visual represent biolog process take place cellular molecular level live organ date molecular imag play import role transit convent medic practic precis medicin among imag modal positron emiss tomographi pet great advantag sensit abil obtain absolut imag quantif correct photon attenu scatter due abil label host uniqu molecul biolog interest includ endogen natur occur substrat drug like compound role pet well establish field molecular imag articl provid overview recent advanc develop pet radiopharmaceut clinic applic oncolog
|
D019275;D049268
|
T060;T121;T130
|
36,296,380
|
heterocycl bis chloroprop en yl sulfid hydrazin hydrat koh synthesi thiophen pyrrol deriv articl devot heterocycl bis chloroprop en yl sulfid proceed hydrazin hydrat alkali medium lead format thiophen pyrrol deriv previous describ tetrahydrocycloocta c c dithiophen well unknown hydrazon methyliden methyldihydrothiophen one amino propynylsulfanylpropenylsulfanyl dimethylpyrrol tentat mechan format heterocycl product discuss obtain hydrazon methyliden methyldihydrothiophen one use synthesi rang azin deriv oxid process seo found reaction open expedi approach format various hard access thiophen pyrrol compound dichloropropen element sulfur start reagent
|
D013876;D011758
|
T121;T109
|
36,296,379
|
anti prolif pro apoptot effect digest aglianico grape pomac extract human colorect cancer cell grape pomac gp major product winemak process still contain bioactiv molecul known benefici properti human health antirad scaveng activ antiprolif activ tumor vitro studi demonstr gp polyphenol specif influenc colon cancer cell prolifer addit previous publish work test phenol compound aglianico gp follow vitro simul gastrointestin digest colorect cancer cell line differ degre differenti experi use ht sw cell confirm anti prolif effect gp gastrointestin digest extract provid intrigu insight way influenc cancer cell featur ie viabil prolifer apoptosi observ aglianico gp extract show great abil affect cell prolifer apoptosi interest ht sw cell produc signific increas bax signific increas baxbcl ratio caspas gastrointestin digest gp extract previous character antioxid activ phenol composit result tpc antioxid activ reach high valu aglianico gp digest extract main compound assess uhplc dad anthocyanin phenol acid flavonoid work shed light use digest gp extract dietari ingredi sustain sourc nutrit compound potenti health benefit colon cancer cell prolifer
|
D027843;D003110;D015179
|
T129;T116;T168;T191;T002
|
36,296,378
|
characterist volatil organ compound analysi differ cistanch base hs gc im cistanch medicin food homolog substanc long histori consumpt medicin use china order understand volatil organ compound differ differ cistanch studi select oil cistanch blood cistanch cistanch tubulosa xinjiang hs gc im volatil organ compound establish characterist fingerprint differ cistanch organ content characterist organ compound analysi pca cluster analysi use studi similar differ cistanch qualit analysi total volatil organ compound identifi cover aldehyd keton furan alcohol lacton ester volatil organ compound sampl b c could signific distinguish affect flavor cistanch provid basic theoret basi studi cistanch flavor
|
D031671;D055549
|
T002;T109
|
36,296,377
|
develop glycyrrhetin acid folat modifi cantharidin load solid lipid nanoparticl target hepatocellular carcinoma cantharidin ctd major compon anticanc drug obtain mylabri cichorii good inhibitori effect sever cancer includ hepatocellular carcinoma hcc breast cancer howev due toxic oral administr caus various advers reaction limit clinic applic aim work design glycyrrhetin acid ga andor folat fa modifi solid lipid nanoparticl slns encapsul ctd target hcc four ctd load slns cantharidin solid lipid nanoparticl cslns glycyrrhetin acid modifi cantharidin solid lipid nanoparticl ga cslns folat modifi cantharidin solid lipid nanoparticl fa cslns glycyrrhetin acid folat modifi cantharidin solid lipid nanoparticl ga fa cslns prepar emuls ultrason dispers method physicochem paramet determin particl size distribut morpholog zeta potenti entrap effici drug load hemolysi addit antitumor activ four slns evalu comprehens test cytotox cell migrat cell cycl apoptosi cellular uptak competit suppress assay vivo tumor suppress assay four slns show spheric shape mean diamet rang nm size dispers pdi within rang zeta potenti approxim mv entrap effici ctd slns higher test formul hemolysi observ compar ga cslns cslns ga fa cslns fa cslns show stronger cytotox hepatocellular carcinoma cell hepg cytotox ga fa cslns hepatocyt cell l remark reduc compar formul ga fa cslns fa cslns also increas inhibit hepg cell migrat fa cslns highest apoptosi rate cell cycl result indic hepg cell arrest main phase gm phase analysi competit inhibit experi show ga fa ligand target effect hepg cell vivo tumor inhibit experi show ga fa cslns fa cslns excel tumor inhibit abil tumor inhibit rate respect result indic ga fa cslns fa cslns promis futur therapeut intervent hcc
|
D006528;D006034;D008113;D053758;D000970
|
T121;T191;T073;T109
|
36,296,376
|
role diacylglycerol kinas amelior diabet nephropathi drastic increas number patient diabet complic global issu diabet nephropathi lead caus chronic kidney diseas signific affect patient qualiti life medic expens furthermor limit drug treat diabet nephropathi patient impair lipid signal especi abnorm protein kinas c pkc activ de novo synthes diacylglycerol dg high blood glucos one caus diabet nephropathi dg kinas dgk enzym phosphoryl dg generat phosphatid acid ie dgk inhibit pkc activ diabet condit inde proven dgk activ amelior diabet nephropathi review summar involv pkc dgk diabet nephropathi therapeut target mechan refer recent studi
|
D003928;D003920
|
T047
|
36,296,375
|
mos mos nanocomposit adsorpt photodegrad water pollut review need fresh conveni treat water becom major concern recent year molybdenum disulfid mos nanomateri attract attent various field energi hydrogen product water decontamin review provid overview recent develop mos base nanomateri water treatment via adsorpt photodegrad primari attent given structur properti major method synthesi modif mos aim effici water contamin remov combin mos compon result nanocomposit separ easili present enhanc adsorpt photocatalyt properti perform materi adsorpt heavi metal ion organ contamin dye drug review review also summar current progress photocatalyt degrad various water pollut use mos base nanomateri uv vis light irradi mos base materi show good activ sever reus cycl real water scenario regard ecotox mos number studi still limit work need effect evalu risk use nanomateri water treatment
|
D014873;D014874;D053761;D019216
|
T131;T196;T073
|
36,296,374
|
g quadruplex aptam ligand character work explor structur g rich dna aptam term l tggtggtggttgttgttggtggtggtggt deriv evalu format stabil g quadruplex g conform differ experiment condit kcl concentr temperatur upon bind varieti g ligand braco pds phendc tmpyp also determin whether nucleolin ncl target l g first assess circular dichroism uv nmr spectroscopi format g l observ kcl concentr mm less l adopt hybrid multipl topolog contrast parallel topolog predomin buffer contain mm kcl l mm kcl c prove weak stabil sequenc also found upon titrat two molar equival braco phendc g strong stabil topolog maintain addit molar equival tmpyp promot disrupt g k valu l g ligand ncl obtain fluoresc titrat rang ligand complex nm ad ncl silico studi suggest four ligand bind l g structur stack interact rbd domain ncl interact preferenti thymin l g final l g co local ncl ncl posit tongu squamous cell carcinoma cell line
|
D052157;D002294;D014062;D054856
|
T191;T114;T086
|
36,296,373
|
hydrolysi rate paraoxonas q r isoenzym silico studi base vitro data human serum paraoxonas pon import hydrolas type enzym found numer tissu notabl exist two isozym form q r exhibit differ activ studi present silico qsar dock md qmmm studi set compound activ toward pon isoenzym qpon rpon differ rate reaction q r isoenzym analyz model effect qr mutat activ site conclud qr mutat even close activ site still chang geometri use combin genet algorithm multipl linear regress ga mlr techniqu sever qsar model develop relat activ rate isozym pon explain two qsar model select one qpon rpon best select model four variabl mlr model q r isozym squar correl coeffici r valu respect addit applic domain model analyz base william plot result discuss light main factor influenc hydrolysi activ pon isozym
|
D043303;D007527
|
T126;T116
|
36,296,372
|
nanozym base dispers hemin graphen quantum dot colorimetr detect glutathion compar natur enzym nanozym advantag good catalyt perform high stabil low cost use extrem condit prepar high activ nanozym simpl method applic bioanalysi high desir work nanozym base dispers hemin graphen quantum dot gqd demonstr enabl colorimetr detect glutathion gsh gqd prepar one step hydrotherm synthesi method hemin catalyt center heme protein low solubl easi aggreg limit catalyt activ dispers gqd simpl sonic prepar hemingqd nanocomplex excel peroxidas like activ appli nanozym comparison natur horseradish peroxidas hrp hemingqd nanozym exhibit clear reduc micha menten constant k tetramethylbenzidin tmb use substrat h substrat hemingqd nanozym exhibit higher maximum reaction rate v max hrp mechan under nanozym activ investig free radic trap experi colorimetr platform capabl sensit detect gsh develop proof concept demonstr linear detect rang low limit detect nm sn determin gsh serum sampl also achiev
|
D006108;D045663;D006420
|
T123;T116;T073;T109;T196
|
36,296,371
|
hierarch virtual screen bind free energi predict potenti modul aed aegypti odor bind protein aed aegypti mosquito main hematophag vector respons arbovirus transmiss brazil disrupt aegypti hematophagi remain one effici least toxic method diseas therefor effort research new chemic entiti repel activ advanc due elucid function olfactori receptor behavior mosquito grow interest pharmaceut cosmet industri develop chemic entiti repel activ comput studi eg virtual screen molecular model way priorit potenti modul stereoelectron characterist eg pharmacophor model bind affin aaeg obp bind site eg molecular dock lower comput cost thus pharmacophor dock base virtual screen employ priorit compound sigma aldrich n biogen databas n addit molecular dynam md perform priorit potenti potent compound compar deet accord free bind energi calcul two compound show adequ stereoelectron requir qfit gt aaeg obp bind site score score gt volatil non toxic properti better bind free energi valu g lt kcalmol compar deet n n diethyl meta toluamid g kcalmol
|
D000330;D018035;D007302
|
T131;T116;T204;T192
|
36,296,370
|
probe integr label free electrochem immunosensor base binari nanocarbon composit detect ca conveni sensit detect tumor biomark crucial earli diagnosi treatment cancer herein present probe integr label free electrochem immunosensor base binari nanocarbon composit surfac immobil methylen blue mb redox probe detect carbohydr antigen ca close associ gastric malign nanocarbon composit consist electrochem reduc graphen oxid carbon nanotub ergo cnt electrodeposit onto indium tin oxid ito electrod surfac form nanocomposit film could provid high surfac area immobil abund mb probe facilit electron transfer mb therefor improv sensit polydopamin pda serv bifunct linker abl immobil anti ca antibodi stabil inner probe confer sens interfac specif recognit capac electrochem detect ca achiev base decreas redox signal mb specif bind ca wide linear rang muml uml limit detect lod numl sn construct electrochem immunosensor good select repeat reproduc stabil furthermor determin ca human serum sampl also realiz
|
D006108;D015374;D037742
|
T073;T075;T109;T104;T196;T059
|
36,296,369
|
non destruct detect moldi walnut base hyperspectr imag technolog walnut shell popular agricultur product china howev mildew growth sometim process food difficult visual determin walnut mildew without break shell non destruct method detect walnut mildew studi combin spectral data imag inform total lling walnut shell use mildew experi characterist spectral data six surfac sampl collect rang nm day spectrum pretreat use snv featur band extract use pca model use support vector machin svm result show overal classif accuraci accuraci inen walnut normal intern extern accuraci imem walnut mildew intern extern reach accuraci imen walnut mildew intern normal extern non destruct detect mildew walnut undertaken use hyperspectr imag technolog provid new techniqu explor mechan walnut mildew
|
D031324
|
T002
|
36,295,662
|
inflammatori biomark prognost factor acut deep vein thrombosi follow total knee arthroplasti background object deep vein thrombosi dvt one serious post oper complic case total knee arthroplasti tka studi aim verifi predict role inflammatori biomark monocyt lymphocyt ratio mlr neutrophil lymphocyt ratio nlr platelet lymphocyt ratio plr system inflammatori index sii system inflamm respons index siri aggreg index system inflamm aisi acut dvt follow tka materi method present studi design observ analyt retrospect cohort studi includ patient year age surgic indic tka admit depart orthoped regina maria health network targu mure romania depart orthoped humanita medlif hospit cluj napoca romania januari juli primari endpoint risk acut dvt follow tka secondari endpoint length hospit stay outcom stratifi baselin optim mlr nlr plr sii siri aisi cut valu result dvt patient associ higher age p higher incid cardiac diseas arteri hypertens p atrial fibril p malign p well risk factor smoke p obes p multivari analysi show high baselin valu hematolog ratio mlr p lt nlr p lt plr p lt sii p lt siri p lt aisi p lt independ predictor dvt tka recruit patient moreov age p ah p af p malign p obes p tobacco p independ predictor dvt risk conclus higher pre oper hematolog ratio mlr nlr plr sii siri aisi valu determin oper strong predict acut dvt follow tka moreov age malign cardiovascular diseas risk factor obes tobacco predict risk factor acut dvt
|
D019645;D020246
|
T061;T047;T046
|
36,295,661
|
high grade endometrioid stromal sarcoma ovari malign transform ovarian matur cystic teratoma report extrem rare case ovarian high grade endometrioid stromal sarcoma aris matur cystic teratoma clinicopatholog featur briefli review pertin literatur year old nullipar woman present lower abdomin pain begun month earlier magnet reson imag show two adnex mass fat compon suggest matur cystic teratoma eccentr thick rim left mass show irregular invas uterus suggest malign positron emiss tomographycomput tomographi demonstr high fluorodeoxyglucos uptak correspond area patient underw debulk cytoreduct surgeri diagnosi intern feder obstetr gynecolog stage iiic high grade endometrioid stromal sarcoma aris matur cystic teratoma surgeri patient receiv adjuv chemotherapi three cours doxorubicin regimen cancer recur month surgeri patient die progress diseas might help clinician awar rare diseas poor prognosi advanc stage
|
D013724;D010051;D012509
|
T191
|
36,295,660
|
headach post covid patient characterist relationship qualiti life littl known characterist headach associ coronavirus diseas covid indonesia object studi describ characterist headach post covid patient impact patient qualiti life qol well determin associ determin poor qol cross section studi conduct banda aceh indonesia demograph characterist clinic symptom covid characterist headach qol collect assess headach diagnos character use intern classif headach disord version ichd qol assess use short form health survey sf tool logist regress model use investig associ determin poor qol post covid patient total post covid patient includ final analysi poor qol due headach follow covid unemploy contract covid less three month prior studi higher odd poor qol compar employ contract covid three month prior studi low qol also relat headach occur less one month recov covid compar occur longer one month high frequenc combin sensat pulsat press fieri stab pain high sever score addit symptom accompani headach conclus headach relat covid associ low qol among post covid patient guidelin prevent measur headach covid patient therefor need establish avoid long term consequ
|
D011788;D000086382
|
T078;T047;T067
|
36,295,659
|
evalu blood intercellular adhes molecul icam level obstruct sleep apnea systemat review meta analysi background object intercellular adhes molecul icam appear activ import biomark decreas risk cardiovascular issu among individu obstruct sleep apnea osa herein systemat review meta analysi design probe whether plasmaserum icam level differ adult osa compar adult osa well adult sever osa compar adult mildmoder osa materi method thorough systemat literatur search perform four databas pubmedmedlin web scienc scopus cochran librari juli without age sampl size restrict retriev relev articl standard mean differ smd along confid interv ci plasmaserum icam level report analys includ sensit analysi subgroup analysi trial sequenti analysi meta regress funnel plot analysi perform pool analysi result total record identifi databas articl includ studi enter meta analysi pool smd serumplasma icam level adult osa compar control ci p lt pool smd serumplasma icam level adult sever compar mildmoder osa ci p higher serumplasma icam level associ higher mean age control higher score apnea hypopnea index lower mean age adult osa smaller sampl size conclus th result present meta analysi show serumplasma icam level adult osa higher serumplasma icam level control similar serumplasma icam level adult sever osa higher compar serumplasma icam level adult mild moder osa therefor icam may use addit diagnost therapeut biomark adult osa
|
D018799;D020181
|
T129;T047;T116
|
36,295,658
|
sensit depend braf mutant colorect cancer cell line without pikca mutat discoveri vulner therapeut potenti background colorect cancer repres common malign remain incur metastat stage identif molecular alter present colorect cancer led introduct target therapi improv outcom braf pikca mutat observ subset colorect cancer colorect cancer bear braf mutat may treat specif braf inhibitor drug benefit patient braf mutant colorect cancer respons rather brief progress rule contrast pik inhibitor proven success yet diseas thus new treatment supplement current avail drug would welcom improv surviv method profil colorect cancer cell line cancer cell line encyclopedia ccle examin braf pikca mutat interrog molecular characterist concomit alter mirror clinic sampl alter genom drug sensit cancer gdsc project use determin drug sensit braf mutat colorect cell line without concomit pikca mutat cancer depend map project serv basi identif molecular depend vulner cell line result ccle includ colorect cancer cell line recapitul molecular landscap colorect cancer cell line possess braf pikca mutat respect seven braf mutant cell line mutat pikca mutant cell line hotspot helic kinas domain mutat braf mutant cell line without hotspot pikca mutat heterogen msi status mimic colorect cancer tissu preval abnorm includ apc tp mutat essenti gene surviv includ ctnnb wrn pyrimidin metabol enzym cad besid braf mutat braf inhibitor sensit colorect cancer cell line confer sac mutat prkn locus loss conclus colorect cancer cell line bear frequent braf pikca mutat present mani alter parent cancer tissu describ vulner repres lead therapeut explor colorect cancer correspond alter
|
D015179;D048493
|
T191;T126;T116
|
36,295,657
|
open sciatic nerv decompress compart syndrom prolong lithotomi posit case report background posit relat compress nerv injuri frequent report complic lithotomi posit contrast compart syndrom induc neuropathi lithotomi prolong surgeri rare prone misdiagnosi case describ success open decompress sciatic neuropathi due compart syndrom prolong lithotomi posit case present year old male patient complain abnorm sensat lower leg difficulti dorsiflexion plantarflexion left foot toe laparoscop anterior hepat sectionectomi h lithotomi posit physic examin reveal sever pain paresthesia distal left thigh manual muscl test grade dorsiflexion plantarflexion left ankl toe classifi grade comput tomographi magnet reson imag show ischem chang mid thigh posterior muscl sciatic nerv sever swollen distal thigh compress proxim edg well leg holder debrid necrot tissu decompress sciatic nerv pain subsid immedi ankl toe dorsiflexion motor function improv grade conclus case report compress neuropathi associ lithotomi posit relat conserv treatment howev lesion compress nerv confirm imag studi correl patient symptom evid earli surgic intervent effect treatment method minim neurolog deficit
|
D003161;D020426
|
T047
|
36,295,656
|
non transfus depend thalassemia panoram review non transfus depend thalassemia ntdt consid less sever transfus depend variant common form ntdt includ thalassemia intermedia hemoglobin ebeta thalassemia hemoglobin h diseas patient ntdt develop sever clinic complic despit regular transfus independ ineffect erythropoiesi iron overload hypercoagul pathophysiolog factor lead morbid patient therefor earli accur diagnosi ntdt essenti ascertain earli intervent current sever convent manag option avail guidelin suggest thalassemia intern feder novel therapi develop light advanc understand diseas review aim increas clinician awar ntdt basic medic definit genet pathophysiolog specif complic ntdt review along risk factor develop indic differ therapeut option outlin recent advanc review
|
D019190;D013789
|
T047
|
36,295,655
|
role mir p mir p let e p patholog respons breast cancer patient neoadjuv therapi background object predict respons therapi remain continu challeng treat breast cancer especi identifi molecular tissu marker best character resist tumour microribonucl acid mirna known master modul tumour phenotyp could help candid predict drug resist aim assess associ mir p mir p let e p breast cancer tissu patholog respons neoadjuv therapi nat clinicopatholog data materi method sixti femal patient diagnos invas breast cancer oncolog institut ion chiricu cluj napoca romania iocn includ studi patient receiv treatment fresh breast tissu biopsi collect core biopsi echograph guidanc process total rna extract mirna quantif cancer genom atlas breast invas carcinoma tcga brca databas use independ extern valid cohort result mir p express associ differenti tumour hormon receptor presenc lymphat invas accord miller payn system higher mir p express calcul patient present intermedi versus vs patholog respons higher mir p express associ improv respons nat miller payn rcb evalu system sever druggabl mrna target correl mir p mir p express upstream analysi use ipa knowledg base reveal list possibl chemic biolog target drug regard let e p signific associ notic analys clinicopatholog data conclus result suggest tumour higher level mir p sensit neoadjuv therapi compar resist tumour higher mir p express respons tumour could indic excel patholog respons
|
D035683;D009369
|
T123;T191;T114
|
36,295,654
|
advers reaction profil relat gastrointestin bleed event associ bcr abl tyrosin kinas inhibitor background object aim studi investig characterist gastrointestin bleed event associ bcr abl tyrosin kinas inhibitor tki treatment use report odd ratio ror advers event report submit japanes advers drug event report databas examin number report tki relat gastrointestin bleed case accord sex age well actual number tki prescript issu japan materi method ror confid interv cis gastrointestin bleed event relat tkis calcul use data includ case result signific gastrointestin bleed event detect dasatinib crude ror ci imatinib crude ror ci multipl logist regress analys signific gastrointestin bleed event detect dasatinib adjust ror ci imatinib adjust ror ci age year adjust ror ci report year adjust ror ci male sex adjust ror ci interact analysi reveal associ gastrointestin bleed dasatinib affect age year sex femal number proport dasatinib relat gastrointestin bleed case increas among age year conclus specif tkis patient characterist associ gastrointestin bleed result aid prompt identif treatment tki relat gastrointestin bleed
|
D015464
|
T191
|
36,295,653
|
clinic outcom socioeconom status psycholog constrain patient undergo preimplant genet test pgt northern greec background object preimplant genet test pgt offer patient possibl healthi babi free chromosom genet disord present studi focus applic pgt patient locat northern greec investig clinic outcom motiv overal physic emot experi treatment associ socioeconom background materi method coupl underw pgt monogen condit pgt n cycl aneuploidi pgt n cycl particip studi fertil implant pregnanc rate record cycl coupl ask fill questionnair consult receiv prior treatment sociodemograph inform psycholog impact pgt femal male partner result fertil implant ongo pregnanc rate pgt pgt cycl respect femal experienc intens physic pain male partner psycholog pain encount partner occasion higher instanc male typic socioeconom background patient refer pgt northern greec notic conclus pgt attract altern prenat diagnosi pnd aim establisha healthi pregnanc identifi avoid transfer chromosom genet abnorm embryo uterus although benefit pgt well receiv patient undergo procedur psycholog pain evid especi promin patient previous affect child normal embryo transfer holist counsel utmost import order make patient experi journey healthi babi less emot demand help make right choic futur
|
D019836
|
T060;T058
|
36,295,652
|
preval iron defici atrial fibril low hang fruit background object atrial fibril af common sustain arrhythmia worldwid relationship af iron defici poor understood materi method conduct observ studi investig preval iron defici af iron defici defin american colleg cardiolog acc criteria iron defici heart failur result elig subject met acc definit iron defici heart failur iron defici like femal p histori diabet mellitus p histori stroke p higher cha ds vasc p charlson comorbid index score cci p conclus preval iron defici af appear high warrant evalu prospect studi
|
D001281;D000090463;D020521;D006333
|
T047;T046
|
36,295,651
|
decreas activ erythrocyt catalas glutathion peroxidas patient schizophrenia background object catalas glutathion peroxidas gpx import antioxid enzym break hydrogen peroxid h order control intracellular concentr thus enabl physiolog role prevent toxic effect lack disrupt function lead accumul hydrogen peroxid occurr oxid stress accumul studi shown activ key antioxid enzym impair patient schizophrenia sinc publish result contradictori previous studi found signific higher erythrocyt superoxid dismutas sod activ patient schizophrenia aim studi determin activ enzym degrad hydrogen peroxid group patient well examin depend clinic symptom therapi paramet associ diseas materi amp nbsp method catalas gpx activ determin erythrocyt inpati schizophrenia age gender match healthi control clinic assess patient perform use posit negat syndrom scale panss catalas activ measur kinet spectrophotometr method gpx activ determin commerci avail ransel test result erythrocyt catalas gpx activ signific lower p lt p lt respect subject schizophrenia healthi individu lower catalas activ depend hered diseas onset number episod diseas durat gpx activ show signific chang patient one episod suffer diseas year signific lower catalas activ note panss group comparison panss panss group lowest catalas activ found subject simultan treat first second generat antipsychot signific lower receiv one class antipsychot conclus result indic presenc oxid stress first year clinic manifest schizophrenia depend number psychot episod ill durat predomin symptomatolog antipsychot medic
|
D012559;D014150
|
T121;T039;T048
|
36,295,650
|
comput tomographi improv intra interobserv agreement hertel radiograph prognost criteria background object proxim humerus fractur second frequent site avascular necrosi avn occur case hertel criteria use refer predict humerus head ischemia howev base sole use radiograph make interpret extrem difficult due sever reason overlap fragment sever injuri noncompli acut pain patient object studi evalu role comput tomographi ct interpret hertel criteria evalu intra interobserv agreement orthoped surgeon compar area expertis materi method radiograph ct scan skelet matur patient fractur proxim humerus convert jpeg mov respect imag evalu eight orthoped surgeon four trauma surgeon four shoulder surgeon two differ occas intra interobserv agreement assess use kappa coeffici level signific result weak moder intraobserv agreement lt examin medial metaphys hing greater mm identifi evalu radiograph ct examin two round studi p lt signific interobserv agreement lt occur moment second round evalu conclus prognost criteria humer head ischemia evalu studi show weak intra interobserv agreement radiograph tomograph evalu ct help surgeon primari interpret hertel prognost criteria use studi compar radiograph examin
|
D014057;D012784
|
T060;T037
|
36,295,649
|
preoper fibrinogen albumin ratio potenti predictor bladder cancer monocentr retrospect studi background object fibrinogen albumin two protein wide use singular combin cancer patient biomark nutrit status inflamm diseas prognosi aim studi investig preoper fibrinogen albumin ratio far preoper predictor malign well advanc grade patient bladder cancer materi method retrospect analysi patient underw turbt institut conduct far obtain preoper venous blood sampl perform within day schedul surgeri analyz relat histopatholog report presenc malign statist analysi perform use kruskal walli test univari multivari logist regress analysi assum p lt statist signific result total patient includ studi male femal mean age year mean far signific higher patient low grade high grade bladder cancer valu respect compar patient without cancer p univari regress analysi report far irrelev consid continu variabl ci p consid categor variabl util cut set ci p lt nevertheless data confirm multivari analysi conclus elev preoper far potenti predictor malign well advanc grade patient bladder cancer data requir suggest promis role fibrinogen albumin ratio diagnost biomark bladder tumor
|
D001749
|
T191
|
36,295,648
|
diabet mellitus predict factor urinari tract infect patient treat kidney transplant background object aim investig rate incid risk factor post transplant urinari tract infect uti patient receiv kidney transplant kt institut materi method retrospect cohort studi carri patient underw kt end stage kidney diseas eskd januari decemb gifu univers hospit uti defin exist bacteri andor fungal infect urin coloni form unitsml without urinari andor system symptom uti patient divid two group uti kt uti group without uti non uti group primari endpoint studi relationship covari uti kt result two hundr forti patient eskd receiv kt gifu univers hospit thirti four particip develop uti surgeri common pathogen escherichia coli end follow graft loss observ six patient independ uti episod multivari analysi diabet mellitus dm statist associ post transplant uti kidney transplant recipi conclus preoper serum glucos control patient dm may crucial role prevent uti preserv renal function kt
|
D016030;D014552;D007676;D003920
|
T061;T047
|
36,295,647
|
clinic evalu short tuberos implant among type diabet non diabet patient year follow aim assess clinic radiograph paramet includ bleed probe bop probe depth pd plaqu index pi crestal bone loss cbl around short tuberos implant sti support fix partial dentur patient type diabet mellitus tdm non diabet materi method particip tdm without tdm least one sti mm posterior restor fix partial dentur splint premolar implant includ questionnair collect demograph detail includ gender age durat diabet habit brush total number dental implant locat implant load placement restor type famili histori dm clinic radiograph assess peri implant paramet ie bleed probe bop probe depth pd plaqu index pi crestal bone loss cbl perform restor success sti determin sensat foreign bodi lack pain dysesthesia lack infect radioluc around implant mobil kruskal walli test use statist analysi p valu less consid statist signific result twenti five tdm male femal non diabet male femal particip includ number stis tdm wherea non diabet year follow mean pi tdm particip non diabet mean pd record diabet mm non diabet mm bop valu diabet non diabet year follow mean pi rang tdm particip non diabet mean pd millimet around sti tdm observ mm mm non diabet addit bop diabet particip non diabet total six stis fail ie two non diabet four tdm group conclus patient tdm poor periodont bop pd cbl restor peri implant paramet around stis compar healthi non diabet particip five year follow long term stabil glycem control pivot along follow good plaqu control
|
D003924;D016301;D015921
|
T047;T074
|
36,295,646
|
safeti feasibl singl port tran axillari robot thyroidectomi experi consecut case background object recent singl port sp robot system introduc minim invas oper techniqu thus studi aim valid safeti feasibl sp tran axillari robot thyroidectomi sp tart experi singl tertiari institut materi method studi retrospect analyz consecut patient underw sp tart octob june seoul st mari hospit seoul korea analyz clinicopatholog characterist periop outcom includ complic result less total thyroidectomi ltt perform total thyroidectomi tt tt modifi radic neck dissect mrnd patient mean oper time min ltt tt tt mrnd respect mean postop hospit stay day respect total case thyroid cancer includ case papillari carcinoma rest follicular poor differenti carcinoma regard complic five case major complic includ three case vocal cord palsi two case transient hypoparathyroid conclus sp tart safe feasibl short oper time short length hospit stay
|
D013965;D065287
|
T061
|
36,295,645
|
perin massag pregnanc prevent postpartum urinari incontin control clinic trial background object urinari incontin involuntari loss urin may result anxieti depress low self esteem social isol perin massag spread prophylact techniqu treat complic labor acknowledg effect perin massag reduct incid sever perin tear use equip direct relat intrapartum perin trauma aim studi determin effect massag urinari incontin prevent identif possibl differ form applic self massag physiotherapist previous assumpt effect differ differ form applic materi method control clinic trial sampl pregnant women conduct particip divid three group group receiv massag appli special physiotherapist anoth group appli massag control group receiv ordinari obstetr care result differ identifi incid sever urinari incontin among three group sever incontin affect bodi mass index weight babi time deliveri conclus relationship perin massag intervent develop urinari incontin observ
|
D007743;D007744;D014549
|
T040;T046
|
36,295,644
|
congenit absenc portal vein rare caus portopulmonari hypertens case studi seri background congenit absenc portal vein capv extrem rare malform caus aberr venous develop embryogenesi usual associ congenit portosystem shunt cpss hemodynam allow mesenter blood bypass liver metabol caus imbal vasodil vasoconstrictor pulmonari circul might lead develop secondari portopulmonari hypertens poph establish exact morpholog splanchnic venous system import evalu possibl therapeut option differenti type ii capv variant enabl closur shunt repres potenti cure pulmonari arteri hypertens pah poph diagnos complex care special expert centr necessari possibl cpss closur recommend long term success patient manag specif target pah therapi administr crucial signific morbid mortal patient may result pah also due specif poph complic compress left main coronari arteri pulmonari arteri aneurysm case report report two patient poph due capv cpss without liver diseas present sever pah admiss expert centr misdiagnos idiopath pah case report also repres experi respect long term follow pah specif medic treatment patient well possibl even fatal complic rare complex patient
|
D000081029;D006975;D006976;D054079
|
T047;T046;T190
|
36,295,643
|
comparison hybrid abdomin flap versus homodigit neurovascular island flap fingertip amput amput level distal phalanx common hand injuri normal treat replant howev level injuri distal vessel stump crush injuri replant viabl option aim studi evalu function aesthet outcom hybrid abdomin flap consist random pattern abdomin skin flap autolog bone graft retrospect analysi perform fingertip amput patient march april patient manag either hybrid abdomin flap haf homodigit neurovascular island flap hnif function aesthet outcom assess three month oper studi total finger treat either haf hnif signific differ rang motion rom scar qualiti two group flap surviv without flap necrosi non union bone observ patient satisfi appear function finger includ rom sensori aspect novel haf function aesthet valid option fingertip amput crush stump
|
D000673;D005383
|
T037
|
36,295,642
|
deep margin elev current concept clinic consider review dietschi spreafico first propos deep margin elev dme address multipl clinic problem associ sub gingiv margin sub gingiv margin reposit coron use composit resin restor given dentistri direct toward conservat use current trend
|
D003188;D005881
|
T122;T024;T023
|
36,295,641
|
spinal meningioma surgeri octogenarian function outcom complic year follow period background object popul age industri nation led increas preval benign spinal tumor spinal meningioma sms elder lead symptom sm local pain diagnosi confirm acut neurolog declin howev littl known optim treatment frail patient group therefor studi sought assess clinic outcom morbid mortal octogenarian sms progress neurolog declin undergo surgeri determin potenti risk factor complic materi method electron medic record date septemb decemb singl institut retriev data patient demograph neurolog condit function status degre disabl surgic characterist complic hospit cours day mortal collect result thirti patient age year diagnos sms underw posterior decompress via laminectomi microsurg tumor resect patient present poor baselin histori mean cci point almost sms locat thorac spine n progress preoper neurolog declin observ n patient mccormick score mmcs mean motor score ms hospit day mortal rate respect ms mmcs improv signific postop p lt uniqu risk factor complic sever comorbid conclus decompress laminectomi tumor remov octogenarian progress neurolog declin improv patient function outcom discharg surgeri seem state art treatment symptomat sms elder patient even poor preoper clinic neurolog condit whenev accept risk anesthesiolog point view
|
D008579;D009422;D008577
|
T047;T191
|
36,295,640
|
anti cxcl autoantibodi potenti diagnost biomark esophag squamous cell carcinoma background object esophag squamous cell carcinoma escc one common malign anti tumor associ antigen autoantibodi taab use biomark tumor detect aim studi identifi reliabl taab diagnost marker escc materi method cancer genom atlas tcga databas use screen candid gene mrna express key gene verifi micro array dataset gse gene express omnibus geo databas diag nostic valu correspond autoantibodi key gene escc detect enzym link im muno sorbent assay elisa result cxcl identifi key gene dataset gse show cxcl mrna express promin express escc tissu compar normal tissu elisa result show level anti cxcl autoantibodi escc patient signific higher normal control receiv oper char ac terist roc curv indic anti cxcl autoantibodi could discrimin escc patient normal control area roc curv auc verif cohort valid cohort respect conclus studi illustr anti cxcl autoantibodi good diagnost valu may becom candid biomark escc
|
D000077277;D004938;D002294
|
T191
|
36,295,639
|
surgic radiolog differ intersphenoid sinus septat preval onodi cell endoscop endonas transsphenoid approach background object understand anatom variat sphenoid sinus import fulli expos sellar floor clivus materi method onodi cell intersphenoid sinus septat base preoper paranas sinus comput tomographi pns ct surgic record patient underw endoscop endonas transsphenoid approach eetsa retrospect review result intersphenoid sinus septum iss block clivus defin pseudoclivus complet incomplet pseudoclivus found patient respect intraop pns ct iss find differ patient misconcept regard ridg vertic iss confus incomplet pseudoclivus vertic iss common conclus intraop pns ct find may differ anatom variat paracliv area evalu care pseudoclivus mimick clivus import attain fulli expos eetsa surgic view
|
D012658;D013101
|
T023;T030
|
36,295,638
|
salivari exosom microrna p microrna b p oral oropharyng squamous cell carcinoma background object research aim evalu capac salivari exosom mir b p mir p oral oropharyng cancer detect materi method saliva sampl harvest histopatholog diagnos oral oropharyng squamous cell carcinoma patient healthi volunt subject exosom isol differenti ultracentrifug quantifi nano track analysi microrna extract quantifi salivari exosom quantit real time polymeras chain reaction result research compris fifti particip compar healthi control salivari exosom mir p elev mir b p reduc oral oropharyng squamous cell carcinoma moreov mir p high express level stage ii cancer comparison cancer stage cancer sampl present increas exosom dimens compar control sampl conclus salivari exosom mir b p mir p alter express oral oropharyng cancer
|
D055354;D035683;D009959;D000077195
|
T026;T123;T191;T114
|
36,295,637
|
relat mid region pro adrenomedullin patient chronic heart failur dose diuret year follow data far nhl registri background object aim paper evalu impact humor substanc mid region pro adrenomedullin mr proadm two year surviv patient chronic heart failur relat dosag furosemid materi method data taken stabl systol heart failur ef lt far nhl registri farmacolog neurohumor activ primari endpoint two year follow death heart transplant lvad implant result total patient enrol far nhl registri mr proadm level avail mean age year male aetiolog hf ischem heart diseas dilat cardiomyopathi patient mean ef statist signific differ p lt obtain sever paramet patient higher mr proadm level older rate higher nyha class suffer often lower limb oedema comorbid hypertens atrial fibril diabet renal impair mr proadm level relat furosemid dose patient take higher dose diuret higher mr proadm level mean mr proadm level without furosemid n nmoll low dose n mgday nmoll mid dose n mgday nmoll high dose n mgday nmoll maximum dose n mgday nmoll p lt patient higher mr proadm level like achiev primari endpoint two year follow p lt accord multivari analysi conclus elev plasma mr proadm level patient chronic heart failur associ increas risk death hospit higher mr proadm level combin increas use loop diuret reflect residu congest associ higher risk sever diseas progress
|
D053607;D006333
|
T121;T047;T046;T116
|
36,295,636
|
vascular function recoveri follow satur dive background object satur dive techniqu use commerci dive decompress sick dcs main concern satur safeti procedur evolv last year dcs becom rare event new need evolv evalu dive decompress stress improv flexibl oper minimum interv dive optim oxygen level etc monitor stress satur diver actual oper materi method monitor includ detect vascular gas emboli vge chang vascular function measur flow mediat dilat fmd final decompress surfac monitor perform onboard dive support vessel oper north sea typic storag depth msw total diver sign inform consent form particip studi data collect diver surfac satur h follow end final decompress result vge detect three diver low level insignific confirm improv achiev satur decompress procedur expect fmd show impair vascular function immedi end satur diver diver fulli recov vascular chang next follow hour regardless initi decompress start depth conclus chang suggest oxidativeinflammatori dimens divingdecompress stress satur requir monitor investig even vascular impair found recov fast
|
D004242;D003665
|
T056;T047
|
36,295,635
|
updat current emerg use thiazolidinedion type diabet guidelin increas stress concept adequ glycem control requir prevent decreas macro microvascular complic type diabet mellitus tdm ppar gamma agonist glitazon longer priorit due effect heart failur howev associ drug innov therapi could valuabl tool attenu risk factor metabol syndrom glitazon use treatment diabet associ comorbid substanti scientif evid demonstr effect glitazon cardiometabol level well hematolog neurolog patholog point use use glitazon alway controversi type patient must take drug side effect associ unfortun recent guidelin includ among prefer drug treatment hyperglycemia rosiglitazon market mani countri due advers cardiovascular risk profil even though real life studi proven otherwis pleiotrop effect highlight unabl achiev primaci choic antihyperglycem drug would appropri demonstr use pioglitazon therapeut benefit cardiovascular safeti studi
|
D045162;D003924
|
T121;T047;T109
|
36,295,634
|
function outcom cochlear implant children bilater cochlear nerv aplasia background object mani otologist face dilemma decis make process surgic manag patient cochlear nerv cn aplasia goal studi provid fresh evid cochlear implant ci result patient cn aplasia materi method scrutin function outcom ear children bilater cn aplasia underw unilater bilater ci base cross section longitudin assess result categori auditori perform cap score gradual improv throughout year follow howev variabl outcom exist individu specif recipi year postop cap score could achiev cap score even year postop evalu recipi year postop cap score gt improv auditori perform abl achiev cap score higher meanwhil intraop electr evok compound action potenti correl postop cap score conclus result refin previous studi clinic feasibl ci first treatment modal elicit favor auditori perform children cn aplasia howev special attent paid pediatr patient earli postop cap score identif unsuccess cochlear implant switch auditori brainstem implant
|
D019929;D003054
|
T061;T074
|
36,295,633
|
applic valu system inflammatori index clinic evalu patient heart failur preserv eject fraction hfpef background area medic resourc scarc econom conveni way assess patient condit treatment plan adjust time manner make sens clinic valu system inflammatori index sii neutrophil lymphocyt ratio nlr lymphocyt monocyt ratio lmr albumin gamma glutamyl transferas ratio agr white blood cell count mean platelet volum ratio wmr high densiti lipoprotein cholesterol c reactiv protein ratio hcr etc explor heart failur hf preserv eject fraction hfpef easi avail clinic valu diagnosi therapi prognosi cardiovascular diseas method inpati includ patient new york heart associ nyha control group patient nyha ii iv studi group first affili hospit jinan univers period juli march includ retriev electron medic record logist regress analysi spearman correl coeffici oper characterist curv etc use analyz data result patient hfpef lmr ci p nlr n termin pro b type natriuret peptid nt probnp independ predictor presenc hf lmr ci p nlr fag mhr agr nt probnp independ predictor increas nyha function classif good correl r gt lmr r p nlr wmr hcr nt probnp r p nyha function classif lmr auc ci p nlr nt probnp auc ci p good diagnost valu auc gt hf patient hfpef addit certain correl lmr nt probnp echocardiographi indic cardiac structur conclus sii potenti applic valu clinic evalu patient hfpef follow especi area limit medic resourc conveni cost effect among differ sii lmr probabl promis metric howev larg scale clinic trial need futur confirm find
|
D020097;D006333
|
T123;T121;T116;T125;T047;T046
|
36,295,632
|
invas prenat diagnost test aneuploidi singleton pregnanc compar review major guidelin sophist screen protocol genet abnorm constitut import compon current prenat care aim identifi high risk pregnanc offer appropri counsel parent regard option definit prenat diagnosi possibl invas prenat diagnost test ipdt main includ amniocentesi chorion villous sampl cvs aim compar review summar compar exist recommend ipdt influenti guidelin review guidelin highlight ipdt indic base posit screen test rather matern age alon indic aris medic histori sonographi signific variat identifi guidelin earlier time amniocentesi unequivoc set gestat week wherea cvs earlier limit vari week certain technic aspect overal approach demonstr signific differ periprocedur manag regard rhesus alloimmun virolog status use anesthesia antibiot either inconsist insuffici address synthesi evid base algorithm ipdt crucial import healthcar profession implic prenat care avoid unnecessari intervent without compromis optim prenat care
|
D015193;D000649
|
T060
|
36,295,631
|
relationship facial color chang psycholog problem associ lower back pain background object aim studi determin whether non contact sensor detect complexion chang use assess psycholog state patient chronic lower back pain lbp materi method twenti six patient lbp lbp group mean age year control subject without lbp control group mean age year includ studi subject two group wore headphon ask lbp relat lbp unrel question question facial imag subject captur use video camera complexion subject convert red green blue rgb valu rgb correl coeffici rgbccs rang repres differ complexion lbp relat lbp unrel question high rgbcc indic brain activ lbp relat question lbp unrel question also note score subject numer rate scale nrs japanes orthoped associ back pain evalu questionnair joabpeq pain catastroph scale pcs hospit anxieti depress scale had result signific differ rgbcc control lbp group versus p lbp group correl observ rgbcc examin item nrs joabpeq had contrast correl observ rgbcc rumin subscal pcs lbp group spearman rank correl coeffici p conclus complexion patient catastroph think chang patient ask lbp relat question
|
D017116
|
T184;T047
|
36,295,630
|
mirna express associ hbf saudi sickl cell anemia background object sickl cell anemia sca hereditari monogen diseas due singl globin gene mutat code product sickl hemoglobin phenotyp modul fetal hemoglobin hbf product globin gene explor molecul regul globin gene transcript translat level includ microrna mirna might help identifi altern therapeut target materi method use next generat sequenc identifi pre mirna matur mirna express signatur associ differ hbf level patient homozyg sickl hemoglobin gene involv identifi mirna potenti scd relat pathway investig diana tool mirwalk databas result mir high upregul reticulocyt mir mir p high downregul sickl cell anemia high hbf mir p regul lina mir effect modul globin level also signific upregul mirna target gene pathway interact identifi bcla bcll lina klf gata solut carrier famili gene znf gene associ erythropoiesi cell cycl regul glycosphingolipid biosynthesi camp cgmp pkg mtor mapk pik akt signal pathway cancer pathway conclus mirna signatur target gene identifi novel mirna could regul fetal hemoglobin product might exploit therapeut
|
D000755;D035683
|
T123;T047;T114
|
36,295,629
|
effect hydrofluor acid gel hot etch surfac treatment shear bond strength resin cement zirconia ceram background object consensus regard surfac treatment method achiev optim bond strength zirconia resin cement evalu effect hot etch hydrofluor acid hf gel use zirconia etchant cloud system zirconia surfac consequ shear bond strength sbs differ resin cement surfac treat zirconia ceram materi method forti five zirconia specimen random assign surfac treatment group n group treatment control ct sandblast al air pressur bar sb hot etch hf gel post treatment specimen examin use scan electron microscopi sem surfac rough sr analysi treatment self adhes resin cement maxcem elit mazic cem relyx u esp maplewood mn usa bond zirconia specimen store distil water c h specimen subject sbs test use univers test machin failur data analyz use one way analysi varianc tukey post hoc test result sem imag rough greater sb specimen ra rt valu highest sb follow ct specimen specimen show signific higher sbs valu ct sb specimen p lt mazic cem cement methacryloyloxydcyl dihydrogen phosphat yield highest sbs valu conclus hot etch hf gel safe shell form uniform small defin hole zirconia surfac achiev signific higher sbs valu sandblast p lt zirconia prosthes bond micromechan resin cement without deterior properti due transform use chemic acid etch zirconia etchant cloud system
|
D019279;D006858
|
T131;T122;T197
|
36,295,628
|
assess rational urgent head ct compar analysi referr result examin without contrast enhanc studi analyz correl indic result head ct examin search evid excess use diagnost method total referr urgent head ct analyz retrospect includ follow paramet patient sex age type scan c c angio ct descript symptom presenc diagnost target patholog identifi radiologist assign four class regard sever diagnos condit analysi ct result shown half examin reveal deviat show chronic asymptomat lesion mani referr constitut group term lack diagnost target specif patholog presenc specif clinic target referr correl signific higher frequenc acut diagnosi contrast enhanc follow examin allow unequivoc classif patient extrem class iv accur identif patient requir urgent chronic treatment excess use diagnost imag harm patient often unnecessarili expos radiat also qualiti healthcar sinc increas cost radiologist workload
|
D014057;D012017
|
T060;T058;T170;T097
|
36,295,627
|
use ultra widefield fluorescein angiographi guid treatment idiopath retin vascul aneurysm neuroretin case report literatur review review clinic featur diagnosi treatment idiopath retin vascul aneurysm neuroretin irvan report case use ultra widefield fluorescein angiographi uwfa confirm precis stage irvan aid earli treatment patient improv treat intravitr aflibercept inject
|
D031300;D012173;D000783;D003524
|
T121;T129;T190;T047;T046
|
36,295,626
|
visual hallucin follow coronari arteri bypass graft prospect studi background object major heart surgeri patient report visual hallucin attribut psychosi delirium studi aim investig hallucin incid patient coronari arteri bypass graft pump without pump extracorpor circul materi method total consecut patient list elect pump coronari arteri bypass graft prospect enrol studi preoper baselin investig h surgeri postop follow h day surgeri includ cognit test clinic visual acuiti test landolt ring patient report visual hallucin interview use structur survey record type time durat frequenc hallucin patient receiv neurolog examin cranial magnet reson imag indic result patient sampl patient underw pump bypass surgeri patient receiv pump surgeri patient pump group none pump group report transient visual hallucin p could attribut stroke delirium psychosi migrain sever impair vision signific correl observ occurr visual hallucin amount nicotin consumpt aortic clampextracorpor circul time conclus transient visual hallucin occur notic proport patient pump heart surgeri knowledg phenomenon benign import patient prevent anxieti uncertainti treat physician avoid unnecessari medic drug induc delirium
|
D009538;D003693
|
T121;T048;T131;T109
|
36,295,625
|
hypertens crisi relat hospit subsequ major advers cardiac event young adult cannabi use disord nationwid analysi background object grow recreat cannabi use recent report link hypertens sought determin risk hypertens crisi hc hospit major advers cardiac cerebrovascular event macc young adult cannabi use disord cud materi method young adult hospit year hc cud identifi nation inpati sampl octob decemb primari outcom includ preval odd hc cud co primari hospit macc secondari outcom resourc util compar propens match cud cud cohort hc admiss result young cud higher preval hc n cud n higher odd adjust patienthospit characterist comorbid alcohol tobacco use disord cocain stimul use aor ci p cud signific increas adjust odd hc sociodemograph hospit level characterist comorbid tobacco use disord alcohol abus aor ci p among young benign hypertens fail reach signific addit adjust cocainestimul use aor p propens match cud cohort n median age year male black show higher rate substanc abus depress psychosi previous myocardi infarct valvular heart diseas chronic pulmonari diseas pulmonari circul diseas liver diseas cud higher odd caus mortal aor ci p lt arrhythmia aor ci p lt stroke aor ci p cud cohort fewer routin discharg compar hospit stay cost conclus young cud cohort higher rate odd hc admiss cud preval dispar higher subsequ risk caus mortal arrhythmia stroke
|
D002189;D014029;D019966;D006973;D003042;D020521;D002188
|
T121;T109;T131;T002;T033;T047;T167;T048
|
36,295,624
|
manag lung cancer present solitari bone metastasi lung neoplasm main caus cancer relat mortal bone metastasi among common secondari tumor vast major patient also present multipl bone metastas make system adjuv pain therapi prefer surgeri optim approach resect non small cell lung tumor also present uniqu resect bone metastasi fulli establish number paper address subject small case report nevertheless surviv rate seem increas radic surgeri sequenc local versus system treatment alway discuss within multidisciplinari team choos best approach patient target system therapi becom access radic surgeri togeth exist reconstruct method lead increas life expect better qualiti life
|
D008175;D002289;D001859
|
T191
|
36,295,623
|
singl center experi parathyroidectomi use intraop parathyroid hormon monitor background object hyperparathyroid hpt rare endocrin diseas associ elev metabol calcium vitamin phosphat hyperfunct parathyroid gland report experi parathyroidectomi use intraop parathyroid hormon iopth monitor singl tertiari hospit materi method octob januari total patient underw parathyroidectomi hpt classifi patient two group primari hpt phpt n renal hpt rhpt n review patient data includ general characterist laboratori result periop complic result thirti five thirti seven patient phpt group underw focus parathyroidectomi ten patient rhpt group underw subtot parathyroidectomi iopth monitor base milan criteria use case preoper week month month postop parathyroid hormon pth level within normal rang phpt group wherea higher normal rhpt group transient hypocalcemia occur rhpt group calcium level return normal level month surgeri conclus parathyroidectomi iopth monitor hospit show favor clinic outcom howev owe small number patient due low frequenc parathyroid diseas long term prospect studi need futur
|
D016105;D006961
|
T061;T047
|
36,295,622
|
nocicept level index direct erector spina plane block open heart surgeri random control clinic trial background object erector spina plane block espb multimod opioid spare compon provid chest wall analgesia variabl extent durat intens object examin espb effect periop opioid usag postop rehabilit use within nocicept level nol index direct anesthet protocol materi method prospect random control open label studi perform adult patient undergo pump cardiac surgeri singl tertiari hospit eighti three adult patient met elig criteria random alloc group control n group espb n receiv general anesthesia nol index direct fentanyl dose preoper group also receiv bilater singl shot ultrasound guid espb mgkgside ropivacain mix dexamethason mg ml postop group receiv intraven paracetamol g everi h morphin mgkg administ numer rate scale nrs score result median iqr th th percentil intraop fentanyl h morphin dose group group vs gkg h p lt vs gkg p lt median iqr time extub group group vs min p lt two hour icu admiss espb patient extub compar control p lt wean norepinephrin compar control p lt median nrs score h extub signific decreas group differ opioid relat advers event length stay conclus nol index direct espb reduc intraop fentanyl h morphin also hasten extub liber vasopressor support improv postop analgesia
|
D009407;D006348
|
T061
|
36,295,621
|
human papillomavirus risk colorect cancer analysi nationwid claim data background object although human papillomavirus hpv major etiolog cervic anogenit cancer whether associ colorect carcinogenesi yet undetermin materi method longitudin associ hpv infect colorect cancer crc evalu use data nationwid taiwanes claim databas retrospect cohort studi patient primari hpv diagnos hpv infect cohort patient without diagnosi hpv uninfect cohort recruit cohort follow identifi crc incid hazard ratio hrs confid interv cis deriv cox proport hazard model use estim associ hpv crc risk result hpv infect cohort signific higher cumul incid crc hpv uninfect cohort presenc hpv associ increas risk crc adjust hr ci furthermor signific hpv crc risk associ evid sex conclus popul base cohort studi reveal longitudin evid hpv associ increas risk crc studi requir verifi role hpv colorect carcinogenesi
|
D030361;D052685;D015179
|
T047;T191;T005
|
36,295,620
|
could increas percentag immatur granulocyt accompani dyspepsia predict covid background aim although vaccin practic continu fast pace around world sever acut respiratori syndrom coronavirus sar cov still threaten peopl live studi aim determin presenc sar cov patient typic symptom novel coronavirus diseas covid present dyspepsia investig role immatur granulocyt earli diagnosi patient materi method adult pediatr patient suffer dyspepsia includ studi patient divid two group posit negat base sar cov polymeras chain reaction test result immatur granulocyt count ig immatur granulocyt percentag ig c reactiv protein crp neutrophil lymphocyt ratio nlr valu record result total patient includ pediatr adult patient includ studi total pediatr patient adult patient test posit sar cov ig ig crp paramet signific higher sar cov posit patient compar sar cov negat patient optim cut valu predict covid infect determin sensit specif p ig conclus note dyspepsia may also covid symptom ig valu determin hemogram test cheap easili access test may warn earli detect patient typic symptom covid
|
D000086382;D004415
|
T184;T047;T067
|
36,295,619
|
effect laser micro groov platform switch implant abut earli crestal bone level peri implant soft tissu post year load among diabet patient control clinic trial background object studi aim compar mean crestal bone level cbl peri implant soft tissu paramet laser micro groov lmg platform switch implant abut post year function load among non diabet type ii diabet individu materi method patient edentul site minimum bone height width mm mm respect divid two group non diabet control ii diabet test lmg implant place load immedi provision prosthesi mean crestal bone level mcbl evalu radiograph baselin year peri implant attach level pial relat posit gingiv margin r pgm record implant stabil quotient isq level implant surviv rate isr evalu year result earli mcbl within group year postload similar mesial distal control mm mm respect test mm mm respect statist signific p p p p respect howev intergroup comparison show signific differ statist mcbl year post function load peri implant soft tissu paramet show signific differ group isq level group reveal signific chang p isr conclus lmg implant result minim compar earli crestal bone loss soft tissu chang post year function load moder control diabet non diabet individu suggest could reliabl system use system compromis individu
|
D016301;D009066;D003920
|
T033;T047
|
36,295,618
|
cytomegalovirus pneumonia patient x link agammaglobulinemia case report x link agammaglobulinemia xla hereditari immun disord predispos patient frequent sever bacteri infect caus encapsul bacteria streptococcus pneumonia staphylococcus aureus haemophilus influenza otiti media sinus pneumonia common complic xla requir prompt diagnosi treatment cytomegalovirus cmv caus widespread sever infect immunocompromis individu affect respiratori tract consequ lead pneumonia associ high mortal rate howev cmv induc pneumonia rare report patient xla case studi detail year old male patient xla present fever product cough dyspnea patient diagnos cmv pneumonia recov treatment best knowledg first report case cmv pneumonia patient xla taiwan case studi emphas cmv pneumonia patient xla treatabl condit diagnos prompt shorter durat treatment antivir agent combin immunoglobulin replac therapi resolv symptom
|
D011014;D003586
|
T047;T050
|
36,295,617
|
hepat fat quantif multi materi decomposit algorithm use low dose non contrast materi enhanc dual energi comput tomographi prospect enrol cohort earli diagnosi hepat steatosi import studi assess hepat fat quantif use low dose dual energi comput tomographi ct assess accuraci hepat fat quantif use multi materi decomposit mmd algorithm low dose non contrast materi enhanc dual energi ct retrospect review prospect enrol patient undergon low dose non contrast materi enhanc dual energi ct magnet reson imag mri proton densiti fat fraction pdff day percentag fat volum fraction fvf imag generat use mmd algorithm low dose dual energi ct data assess correl fvfs mri pdffs use spearman rank correl cutoff valu mri pdff fatti liver receiv oper characterist roc curv analysi perform identifi optim criteria fvf diagnos fatti liver ctdivol ct mgi fvf show strong correl mri pdff r roc curv analysi demonstr fvf optim cutoff fatti liver cutoff valu diagnos fatti liver low dose dual energi ct sensit specif area curv respect mmd algorithm use low dose non contrast materi enhanc dual energi ct feasibl quantifi hepat fat
|
D011522;D005234
|
T196;T047
|
36,295,616
|
forens diagnosi freshwat saltwat drown use marker aquaporin immunohistochem studi background object aquaporin famili water channel protein studi renal intrapulmonari express aquaporin aqp examin forens autopsi case evalu drown marker differenti freshwat drown saltwat drown materi method case classifi three group freshwat drown fwd saltwat drown swd control ctr sampl obtain forens autopsi less h postmortem fwd case swd case case subject histolog immunohistochem investig result fwd group intrapulmonari aqp express signific suppress compar swd ctr signific differ aqp express among two group differ express also observ kidney conclus observ suggest aqp express alveolar cell suppress hypoton water prevent hemodilut moreov possibl hypothes kidney appear hypo osmot plasma aqp hypo express vital reaction regul renal reabsorpt water conclus analysi renal intrapulmonari aqp express would forens use differenti fwd swd fwd death due caus
|
D004332
|
T037
|
36,295,615
|
predict valu eosinophil indic major cardiovascular event patient acut decompens hfref background object heart failur chronic diseas high risk mortal morbid patient inflammatori marker shown associ cardiovascular advers outcom diseas progress investig relationship eosinophil indic major cardiovascular event mace patient acut decompens heart failur adhf reduc eject fraction materi method total consecut patient admit intens care unit icu adhf reduc eject fraction januari decemb enrol retrospect studi mace defin composit death hospit adhf within month index hospit caus mortal mace assess respect relationship eosinophil indic includ neutrophil eosinophil ratio ner leukocyt eosinophil ratio ler eosinophil lymphocyt ratio elr eosinophil monocyt ratio emr result ner ler signific higher subject mace absolut eosinophil lymphocyt basophil count hemoglobin serum na albumin crp emr elr signific lower subject mace compar without nt probnp ci p na ci p lt ner ci p lt ler ci p lt emr ci p elr ci p lt eosinophil count ci independ predictor develop mace conclus patient adhf reduc eject fraction develop mace within first six month index hospit lower level absolut eosinophil lymphocyt count emr elr valu wherea ner ler higher compar without mace eosinophil indic independ associ mortal mace develop eosinophil indic may use estim mace likelihood accept sensit specif
|
D006333;D018487
|
T047;T046
|
36,295,614
|
integr analges care current human monkeypox outbreak perspect integr holist approach combin old alli innov technolog monkeypox mpx zoonot infect caus orthopoxvirus endem central western africa mpx virus part famili virus variola virus caus smallpox sinc may global increas incid mpx infect multipl countri ill usual preval grow number public emphas need increas awar among health profession rapid recognit diagnosi diseas proper public health measur howev atyp present occurr uncommon symptom receiv less desir attent specif mpx infect relat nocicept symptom current underexpos nevertheless report current outbreak reveal sever pain one major caus distress even hospit patient serious pain condit integr multidisciplinari holist approach indic approach multimod includ non pharmacolog therapi alongsid pharmacolog approach health care profession awar avail altern first choic analges therapi fail protocol identif pain type prolong monitor clinic status implement improv patient well acut infect also prevent chronic nocicept syndrom
|
D045908
|
T047
|
36,295,613
|
differenti express enolas clinic gastric tissu cultur normalcanc cell respons helicobact pylori infect caga transfect background object role enolas eno helicobact pylori relat gastric lesion might critic factor pathogenesi remain undefin materi method studi investig differenti express enolas clinic gastric specimen cultur normalcanc cell respons h pylori caga infect caga transfect use qpcr western blot histochem method result total gastric specimen collect patient former compris chronic superfici gastriti csg precancer diseas pcds includ atroph gastriti intestin metaplasia dysplasia gastric cancer gc case among csg pcd case h pylori infect group signific elev eno mrna level compar uninfect group gc case differenti eno express detect cancer tissu paracancer tissu notabl signific differ first detect gc cell ag normal cell ges respons eno h pylori infect caga transfect conclus report reveal eno express associ h pylori infect caga transfect co cultur durat multipl infect gastric normalcancer cell line cellular differenti find may crucial base ascertain h pylori pathogen mechan formul novel therapeut diagnost strategi
|
D016481;D016480;D013274;D011230
|
T047;T007;T191
|
36,295,612
|
myositi ossifican aneurysm bone cystic chang thorac paraspin region case report myositi ossifican mo benign heterotop bone format muscl soft tissu self limit diseas usual initi trauma often occur extrem bodi report rare case traumat myositi ossifican caus unusu trauma extracorpor shock wave therapi thorac paraspin muscl needl biopsi lesion increas size patient symptom worsen malign soft tissu tumor osteosarcoma differenti excis mass perform final diagnosi mo aneurysm bone cystic chang case rare form mo show unusu caus locat clinic cours patholog result follow instruct case radiologist common diseas entiti unusu manifest
|
D009221;D009220
|
T047
|
36,295,611
|
clinic characterist symptomat cholecyst post gastrectomi patient year experi singl center background object gallbladd gb stone major caus symptomat cholecyst like develop post gastrectomi peopl purpos evalu characterist symptomat cholecyst gastrectomi materi method januari decemb total patient underw oper symptomat cholecyst hospit review patient general characterist oper result patholog result postop complic classifi patient non gastrectomi gastrectomi group divid subtot gastrectomi total gastrectomi group result patient age male proport open surgeri rate signific higher vs p lt oper time longer vs p lt gastrectomi group extend surgeri rate signific higher gastrectomi group vs p lt period gastrectomi symptomat cholecyst signific shorter total gastrectomi group vs p conclus gb stone like develop post gastrectomi patient extend surgeri rate higher period cholecyst shorter total gastrectomi effort prevent gb stone consid post gastrectomi patient
|
D002764;D042882;D017081
|
T061;T047;T031
|
36,295,610
|
invas hypervirul klebsiella pneumonia syndrom origin anorect abscess oppos pyogen liver abscess immunocompet year old man present swell pain lower region left leg last week diagnosi sever pyomyos osteomyel lower left leg caus hypervirul klebsiella pneumonia hvkp along multipl metastat infect kidney lung brain origin anorect abscess virul gene analysi reveal isol k pneumonia harbor rmpa entb ybts kfu iuta mrkd all virul gene belong k capsular serotyp repeat abscess drainag procedur intraven ceftriaxon administ week patient infect control focus clinic featur hvkp origin anorect abscess without pyogen liver abscess suggest hvkp consid causat pathogen pyomyos osteomyel result multipl metastat infect immunocompet patient inform unexpect multipl metastat infect obtain virul analysi k pneumonia
|
D046290;D007710;D052880;D010019
|
T047
|
36,295,609
|
scientif research direct histopatholog immunohistochemistri cutan squamous cell carcinoma scientometr studi introduct cutan squamous cell carcinoma cscc one frequent occur type cancer human scientometr research innov method analyz research trend various domain great implic field medicin materi method search web scienc databas follow establish queri term squamous cell carcinoma skin immunohistochemistri appli inclus exclus criteria total articl select present studi aim analyz base frequenc use keyword scientometr algorithm map base distribut trend research concern csccs result graphic represent base scientometr map present divis keyword seven cluster seven categori research interest defin cluster repres multidisciplinari approach diagnosi treatment csccs cancer diagnost patient outcom histopatholog import manag csccs role progress adequ treatment import immunohistochemistri csccs distribut citat show import avail research csccs analyz first five cite articl includ studi direct concord seven defin cluster conclus scientometr research method reveal interest research multidisciplinari approach use obtain best outcom patient includ target investig well diagnost treatment option trend research reveal histopatholog diagnost immunohistochemistri combin molecular techniqu import tool use establish person diagnosi thus increas qualiti life life expect patient csccs
|
D002294;D012878
|
T191
|
36,295,608
|
neonat healthcar associ conjunct descript studi saudi arabia healthcar associ conjunct hac associ serious ophthalmolog complic neonat includ blind three year retrospect descript studi conduct determin common bacteria associ neonat hac tertiari care hospit saudi arabia inclus criteria defin base center diseas control prevent cdc guidelin diagnosi neonat hac hac clinic suspect conjunctiv swab obtain neonat sent microbiolog lab follow standard protocol univari analysi conduct includ sampl total case met inclus criteria retrospect studi descript analysi show pseudomona aeruginosa lead caus hac case follow escherichia coli klebsiella pneumonia analyz case posit staphylococcus aureus orogastr feed common associ factor hac follow respiratori distress syndrom rds preterm birth found case respect conclud hac alarm healthcar problem bacteria includ gram negat bacteria common caus thus physician awar effect communic microbiologist implement infect control recommend includ hand hygien could minim problem avoid serious complic hac
|
D047928;D003231
|
T047;T046
|
36,295,607
|
outcom robot rehabilit assist devic follow spinal cord injuri prevent secondari associ complic spinal cord injuri scis major consequ patient health life voluntari muscl paralysi caus spinal cord damag affect patient independ follow sci irrevers motor sensori deficit occur spastic muscl paralysi atrophi pain gait disord pain patholog implic whole organ osteoarticular muscular cardiovascular respiratori gastrointestin genito urinari skin metabol disord neuro psychic system rehabilit process subject scis consid complex sinc pathophysiolog mechan biochem modif occur level spinal cord yet fulli elucid review aim evalu impact robot assist rehabilit subject suffer sci term regain mobil major dysfunct patient sci also term improv overal fit cardiovascular function respiratori function well gastrointestin system bone densiti final psychosoci issu base multipl clinic trial pilot studi research literatur topic reveal order increas chanc neuro motor recoveri obtain satisfactori result combin robot therapi complex recoveri treatment specif medic one best decis furthermor use exoskeleton facilit bettergreat autonomi patient well optim social integr
|
D065287;D000067190;D013119
|
T061;T074;T037
|
36,295,606
|
inflammatori disord central nervous system vessel narrat review inflammatori disord central nervous system cns vessel also call cns vasculitid caus substanti disabl even fatal inflamm cns vessel caus primari angiiti cns pacn inflammatori cerebr amyloid angiopathi system inflammatori disord clinic symptom disord often non specif encephalopathi cognit affect abnorm headach focal neurolog symptom diagnost workup includ thorough neuropsychiatr examin blood cerebrospin fluid analysi magnet reson imag mri brain vessel biopsi brain remain gold standard diagnost test time diagnosi treatment initi high import might prevent sever complic ischem hemorrhag stroke review describ specif characterist primari secondari non infecti cns vasculitid help establish diagnosi discuss peculiar diagnost workup present current treatment recommend
|
D020293
|
T047
|
36,295,605
|
polypharmaci older adult alzheim diseas number patient alzheim diseas increas annual patient older adult comorbid physic ill mean often treat combin medic diseas alzheim diseas thus older adult alzheim diseas potenti risk polypharmaci addit drug interact alzheim diseas medic treatment physic ill may reduc efficaci increas side effect articl review polypharmaci drug interact elder patient alzheim diseas focus psychotrop drug
|
D019338;D000544
|
T061;T047;T048
|
36,295,604
|
de novo skin neoplasm liver transplant patient singl center prospect evalu case background object solid organ transplant recipi sotr notabl consid risk develop cutan malign howev exist literatur focus kidney transplant relat non melanoma skin cancer nmscs conflict data publish far nmsc incid among liver transplant recipi ltrs whether ltrs realli consid lower risk remain controversi aim present studi prospect collect data incid cutan neoplasm ltr cohort materi method ltrs transplant hepato pancreato biliari surgeri liver transplant unit modena univers hospit octob june underw post transplant period skin check dermatolog unit accord institut integr care pathway data presenc cutan malign premalign lesion collect everi timepoint result total patient enrol present studi near patient develop cutan cancer andor precancer lesion follow period almost half skin cancer lesion basal cell carcinoma actin keratos ak observ six patient four patient develop situ squamous cell carcinoma one patient diagnos stage malign melanoma otherwis well establish risk factor occurr skin tumor skin phototyp cumul sun exposur famili histori cutan neoplasm seem direct impact skin cancer occurr cohort well immunosuppress regimen occurr non cutan neoplasm conclus close dermatolog follow crucial ltrs share protocol regular skin check particular subset patient need transplant center
|
D016031;D012878;D002280;D055623;D012871
|
T061;T047;T191
|
36,295,603
|
sexual dysfunct women men psoriasi cross section questionnair base studi background object psoriasi lead feel stigmat hinder social function impair qualiti life psoriasi also affect sexual activ still littl research topic present studi investig whether extent psoriasi sever locat extent skin lesion affect sexual dysfunct materi method total women men age year hospit psoriasi exacerb includ studi psoriasi sever assess psoriasi area sever index pasi rang point mean point collect demograph clinic data subject ask complet dermatolog life qualiti index item sexual life questionnair intern index erectil function men result studi found patient survey felt least slight unattract due psoriasi approxim subject skin lesion least occasion affect sex life least sometim avoid sexual contact locat psoriasi particular genit area p face p hand p also signific impact level sexual problem psoriasi signific impact qualiti life qol deterior qol strong correl sexual dysfunct r p lt pasi score r p lt self assess psoriasi sever locat psoriat lesion conclus psoriasi lead various limit especi sphere sexual life patient psoriasi feel stigmat lower self esteem consequ experi signific sexual problem awar co occur psycholog aspect psoriasi routin use valid scale dermatolog practic contribut rapid identif patient sexual dysfunct
|
D012735;D011565
|
T047;T046
|
36,295,602
|
inlay techniqu cortico cancel olecranon bone graft use revis fail distal interphalang joint arthrodesi background object although distal interphalang dip arthrodesi effect surgic method end stage osteoarthr phalang joint nonunion rate dip arthrodesi report rang end devis inlay techniqu cortico cancel olecranon bone graft fail dip arthrodesi studi aim introduc inlay bone graft techniqu fail arthrodesi dip joint demonstr advantag materi method review consecut digit patient undergon dip revis arthrodesi use techniqu institut januari decemb observ outcom measur bone union rate relat complic bone union evalu use follow radiographi quick disabl arm shoulder hand dash visual analog scale vas pain vas satisfact assess patient function perceiv clinic outcom result major complic observ recipi site averag vas pain satisfact dash score improv preoper month surgeri p conclus inlay techniqu cortico cancel olecranon bone graft show excel bone union rate function score nonunion dip joint techniqu may adequ surgic option patient confirm nonunion dip joint persist symptom
|
D056740;D010003
|
T023;T047
|
36,295,601
|
effect safeti rapid gradual urinari decompress urin retent systemat review meta analysi background object trial evalu effect safeti rapid gradual urinari decompress publish decad due inconclus result studi aim assess whether rapid bladder decompress increas complic adult acut urinari retent materi method search cochran librari embas googl scholar pubm databas articl publish databas incept august studi compar effect complic rate rapid gradual urinari decompress adult acut urinari retent includ primari outcom post decompress hematuria secondari outcom circulatori collaps meta analys conduct use random effect model sensit analys test public bias trial sequenti analys conduct prospero registr number crd result overal four articl includ comprehens analysi particip met elig criteria primari meta analysi four studi group rapid urinari decompress increas risk post decompress hematuria rr ci p statist p indic substanti heterogen meta analysi random control studi result chang rr ci p egger test begg test p respect indic absenc statist evid public bias leav one sensit analysi conduct show pool result robust secondari outcom report event circulatori collaps current studi conclus current avail data suggest rapid urinari decompress effect safe method complic rate similar gradual decompress acut urinari retent popul larg scale random studi requir
|
D016055
|
T033
|
36,295,600
|
factor predict malign occurr polyp recurr endoscop resect larg colorect polyp singl center experi background aim studi identifi risk factor contribut malign colorect polyp well risk factor recurr success endoscop mucos resect larg colorect polyp referr center materi method retrospect cohort studi perform patient diagnos larg mm diamet colorect polyp treat period januari decemb univers hospit medic center bezanijska kosa belgrad serbia base endoscop evalu classif polyp follow procedur perform en bloc resect piecem resect surgic treatment result total patient larg colorect polyp includ studi major studi popul male mean age year major patient one polyp less mm size sessil morpholog type iia polyp polyp local descend colon access polyp complic patient en bloc resect success perform patient rate piecem resect due incomplet endoscop resect surgeri perform patient patient refer surgeri direct hematochezia p type iib polyp p lt complic polyp access p signific independ predictor carcinoma presenc multivari logist regress analysi patient enrol studi follow endoscop resect colorect polyp recurr observ patient follow piecem resect p incomplet resect success p signific independ predictor polyp recurr multivari logist regress analysi conclus whenev endoscopist encount complex colorect lesion ie polyp complic access polyp size gt mm later spread tumor nongranular lst ng morpholog type type iib polyp presenc hematochezia malign risk consid make decis either resect refer advanc endoscopist perform surgeri
|
D003111;D015179
|
T191;T190
|
36,295,599
|
rs polymorph program death pd gene associ increas risk saudi arabian popul colorect cancer checkpoint program death pd identifi immunosuppress molecul implic immun evas transform cell high express tumor cell order evad host immunosurveil studi aim assess associ singl nucleotid polymorph snp pd risk colorect cancer crc saudi popul case control studi taqman assay method use genotyp three snps pd gene crc patient healthi control associ estim use odd ratio or confid interv cis multipl inherit model codomin domin recess domin log addit moreov pd gene express level evalu use quantit real time pcr colon cancer tissu adjac colon tissu found pd rs allel associ increas risk develop crc p addit pd rs aa homozygot genotyp associ high risk develop crc codomin p recess p addit p model weak protect effect found rs gg genotyp p signific associ found rs crc haplotyp analysi show rs rs rs g haplotyp associ signific increas risk crc p
|
D015179;D020022
|
T032;T191
|
36,295,598
|
associ univers student covid vaccin intent behavior toward protect percept regard pandem background object covid pandem serious global health problem vaccin suggest one efficaci precautionari measur combin protect behavior purpos studi explor associ student intent get vaccin covid protect behavior percept pandem materi method studi sampl includ univers student electron complet two valid questionnair anonym voluntarili decemb januari result result multipl linear regress analysi show perceiv general risk get lower number protect behavior signific diminish p lt addit respond believ minor person risk undertaken signific fewer prevent behavior comparison particip thought major person risk p howev experi respond peopl covid statist signific associ undertak prevent behavior p lower general percept risk statist signific associ lower determin obtain vaccin covid p lt person know someon coronavirus undertak behavior chang due coronavirus situat signific relat greater determin obtain vaccin covid p p lt respect conclus result studi provid univers appropri inform improv covid vaccin strategi
|
D000086382;D014612
|
T129;T121;T116;T067;T047
|
36,295,597
|
chang size periap lesion root canal treatment assess digit periap radiographi cone beam comput tomographi year prospect clinic studi background object limit inform regard comparison long term dynam periap bone destruct estim digit periap radiographi dpr cone beam comput tomographi cbct studi aim compar radiograph assess periap chang endodont treat teeth year follow analys disagr periap lesion size estim around root use dpr cbct materi method total endodont treat teeth patient apic periodont assess dpr cbct baselin year periap radioluc categoris sever concern size descript statist use report distribut radioluc baselin follow size transit year site specif comparison radioluc identifi two method perform use z test pearson chi squar test result major detect radioluc score baselin follow dpr cbct respect site specif score comparison show disagr compris total number radioluc detect dpr cbct respect disagr dpr cbct within categori compar baselin compris two year detect radioluc within categori non match score transit two year occur cbct base evalu result negat treatment outcom root canal dpr base result conclus remark disagr dpr cbct record observ within radioluc categori howev diagnost accuraci radiograph method question result high proport non match lesion transit year
|
D019553
|
T047
|
36,295,596
|
perilipin isoform pgc regul differenti rat heart pregnanc induc physiolog cardiac hypertrophi background object perilipin plin lipid droplet associ protein particip regul lipid storag metabol plin isoform known form nuclear complex peroxisom prolifer activ receptor gamma coactiv alpha pgc regul lipid metabol gene express howev chang plin isoform express respons pregnanc induc cardiac hypertrophi thorough studi aim studi quantifi mrna express plin isoform pgc along total triacylglycerol tag cholesterol level late pregnanc postpartum period rat left ventricl materi method femal spragu dawley rat divid three group non pregnant late pregnanc postpartum mrna protein level evalu use quantit rt pcr western blot respect tag total cholesterol content evalu use commerci colorimetr method result express mrnas plin increas pregnanc postpartum period pgc mrna protein express increas pregnanc postpartum period moreov tag total cholesterol increas pregnanc return basal level pregnanc conclus result demonstr pregnanc upregul differenti express plin isoform along pgc suggest togeth might involv regul lipid metabol shift induc pregnanc
|
D014157;D047492
|
T123;T116;T192
|
36,295,595
|
automat plaqu remov use dual energi comput tomographi angiographi diagnost accuraci util patient peripher arteri diseas background object studi aim evalu util accuraci dual energi automat plaqu remov de apr patient symptomat peripher arteri diseas pad use digit subtract angiographi dsa refer standard materi method retrospect analyz patient pad underw de comput tomographi angiographi de cta dsa lower extrem de cta use generat apr subtract imag three main arteri segment aorto iliac segment femoro poplit segment knee segment presenc absenc hemodynam signific stenosi gt calcif assess use imag cta data analyz use differ imag approach de standard reconstruct imag de sr de apr maximum intens project imag apr de sr apr result segment evalu sensit specif accuraci detect signific stenosi respect de sr respect apr respect de sr apr de sr apr greater accuraci de sr apr alon p lt p lt respect analyz base vascular wall calcif accuraci de sr apr remain greater regardless calcif sever wherea de sr show consider reduct accuraci moder sever calcif case apr degre vascular wall calcif signific influenc accuraci aorto iliac femoro poplit segment de sr apr achiev signific higher diagnost accuraci lower extrem segment evalu hemodynam signific stenosi patient symptomat pad transcend impact vascular wall calcif compar de sr conclus apr demonstr favor diagnost perform aorto iliac femoro poplit segment exhibit good agreement dsa even case moder sever vascular wall calcif
|
D058729;D061205
|
T047
|
36,295,594
|
pulmonari involv sar cov infect estim myocardi injuri risk background object sever acut respiratori syndrom coronavirus sar cov infect repres patholog primari pulmonari involv multisystem impact includ cardiovascular injuri present studi aim assess valu clinic biochem imag factor covid patient determin sever myocardi involv creat model use toevalu myocardi injuri risk base clinic biochem imag factor materi method perform observ cohort studi consecut patient evalu age sex hospit period peripher oxygen satur spo ambient air systol diastol blood pressur heart rate respiratori rate biochem marker cardiac dysfunct tni nt probnp inflammatori marker c reactiv protein crp fibrinogen serum ferritin interleukin il tumor necrosi factor alpha tnf dimer lactat dehydrogenas ldh myoglobin radio imag paramet patient underw computer tomographi chest scan first two day follow admiss result observ elev heart respiratori rate higher systol blood pressur lower diastol blood pressur patient cardiac injuri signific differ group regist tni nt probnp ldh crp dimer radiolog paramet found proport correl myocardi injuri sever lung diseas number pulmonari segment alveolar consolid number pulmonari lobe pneumonia crazi pave pattern type lung involv extent fibroatelectat lesion mediastin adenopathi conclus myocardi injuri occur patient studi group ground glass opac interstiti interlobular septal thicken crazi pave pattern fibroatelectas lesion alveolar consolid ct scan correl myocardi injuri routin lung section imag along non specif biomark ldh dimer crp valuabl character diseas burden thus impact patient care
|
D000086382
|
T047;T067
|
36,295,593
|
viabil criteria liver ex situ normotherm hypotherm perfus increas use extend criteria donor machin perfus becam benefici altern cold storag preserv strategi donor liver intent expand donor pool normotherm hypotherm approach achiev good result term mid long term outcom liver transplant mani marker molecul propos assess liver definit criteria graft viabil valid larg clinic trial key paramet perfus still requir optimizationin review address current literatur viabil criteria normotherm hypotherm machin perfus discuss futur step evolut technolog
|
D009926;D016031
|
T061
|
36,295,592
|
autom analysi vs expert read nuclear cardiolog correl angiograph score background object myocardi perfus imag mpi import role non invas investig coronari arteri diseas interpret mpi studi main base visual evalu reconstruct imag autom quantit method may add use data patient howev littl evid current avail regard actual increment clinic diagnost perform autom mpi analysi present studi aim assess correl autom measur sum stress score sss sum rest score srs sum differ score sds correspond expert read valu use coronari angiographi gold standard materi method studi conduct nuclear medicin laboratori univers hospit larissa larissa greec ver one year period januari januari patient known suspect coronari arteri diseas enrol studi particip underw coronari angiographi prior scintigraph studi within three month period either symptom limit treadmil test pharmacolog test use adenosin regadenoson perform particip scintigraph studi carri use technetium mtc tetrofosmin one day stressrest protocol coronari angiographi score accord point score system angiograph score normal studi one vessel diseas two vessel diseas three vessel diseas moreov autom measur sss srs sds deriv three wide avail softwar packag emori cardiac toolbox myovat quantit perfus spect result interclass correl coeffici sss srs sds expert read softwar packag moder excel visual defin sss srs sds signific correl correspond result softwar packag howev visual defin sss srs sds strong correl angiograph score indic better perform expert read compar autom analysi conclus base result visual evalu continu crucial role interpret mpi imag softwar packag provid autom measur sever paramet particular contribut investig case ambigu scintigraph find
|
D003324;D055414;D002309
|
T060;T047;T091
|
36,295,591
|
vertebr augment time get past pain consensus statement sardinia spine stroke congress vertebr augment use treat pain vertebr compress fractur metastat lesion million patient around world intern group subject matter expert consid evid includ limit mortal consider led ask whether appropri allow subject measur pain domin clinic decis whether proceed augment discuss ensu relat
|
D050815;D054854;D016103;D020521
|
T061;T047;T046;T037
|
36,295,590
|
periop manag clinic outcom liver transplant children homozyg famili hypercholesterolemia background object liver transplant lt accept life save option last resort children homozyg famili hypercholesterolemia hofh periop manag lt hofh pose extra challeng clinician larg due prematur atherosclerot cardiovascular diseas ascvd aim analyz data pediatr lt recipi hofh special attent paid periop manag clinic outcom materi method obtain approv local ethic committe clinic data pediatr patient hofh underw lt institut januari februari retrospect studi result six pediatr lt recipi hofh includ analysi although ascvd common lt children hofh surviv periop period without hospit mortal howev one patient experienc acut myocardi infarct two month follow lt success treat medic intervent post lt metabol improv shown declin serum total cholesterol tc low densiti lipoprotein cholesterol ldl c level earli post lt period tc mmoll vs mmoll p lt ldl c mmoll vs mmoll p lt respect last follow tc mmoll vs mmoll p ldl c mmoll vs mmoll p respect dietari restrict could lift lt howev three patient requir restart lipid lower therapi lt due suboptim ldl c level progress ascvd conclus data suggest lt safe feasibl therapeut option well select patient hofh offer relax dietari restrict remark reduct ldl c level howev concern remain regard progress ascvd lt
|
D006938;D000090542;D016031;D050197
|
T061;T047;T046
|
36,295,589
|
long term prognost valu myocardi viabil myocardi contrast echocardiographi patient acut myocardi infarct systemat review meta analysi background object accord recent guidelin myocardi contrast echocardiographi mce recommend detect residu myocardi viabil mv howev long term prognost valu mv assess mce identifi major advers cardiac event mace acut myocardi infarct ami remain undefin materi method search multipl databas includ pubm embas web scienc studi prognost valu mce clinic outcom ami patient primari endpoint mace follow six studi evalu total patient mean follow month review result pool sensit specif mce predict mace respect summari oper receiv characterist achiev area curv pool relat risk demonstr mv evalu mce ami correl high risk total cardiac event pool relat risk confid interv cardiac death pool relat risk confid interv mv evalu mce high independ predictor total cardiac event pool hazard ratio confid interv patient ami conclus residu mv evalu mce may effect long term prognost tool predict mace patient ami provid moder predict accuraci assess mv mce may becom altern techniqu potenti rapid provid import inform improv long term risk stratif patient ami bedsid clinic practic especi patient toler prolong examin prospero registr number crd
|
D004452;D009203
|
T060;T047
|
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