PMID
int64 35.7M
36.4M
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36,296,508
|
influenc molecular weight polysaccharid laminaria japonica ljp base hydrogel anti inflammatori activ wound heal process studi polysaccharid laminaria japonica ljp produc treatment ultraviolethydrogen peroxid uvh degrad differ molecular weight degrad ljp use prepar ljpchitosanpva hydrogel wound dress molecular weight ljp decreas kda kda swell ratio ljp base hydrogel rose fold origin weight howev mechan properti ljp base hydrogel slight decreas extens uvh degrad time molecular weight ljp gradual decreas anti inflammatori activ ljp base hydrogel gradual increas ljp degrad min gel show best inhibit effect proinflammatori cytokin content tnf il il decreas respect compar model group result suggest low mw ljp base hydrogel show great potenti wound dress applic
|
D007795;D048271
|
T121;T204;T109
|
36,296,507
|
hydroxi phenylcoumarin multitarget compound skin age diseas synthesi molecular dock tyrosinas elastas collagenas hyaluronidas inhibit sun protect factor skin age progress biolog process human bodi time depend differ substitut phenylcoumarin prove effici inhibit tyrosinas current work new substitut pattern explor biolog studi extend import enzym involv process skin age elastas collagenas hyaluronidas studi seri five compound present inhibitori activ tyrosinas one compound elastas eight compound collagenas two compound hyaluronidas five compound dual inhibitor bromophenyl dihydroxycoumarin bromophenyl dihydroxycoumarin present best profil tyrosinas ic collagenas ic bromophenyl dihydroxycoumarin present good inhibit tyrosinas hyaluronidas bromophenyl dihydroxycoumarin show effect tyrosinas elastas inhibit dihydroxi hydroxyphenyl coumarin present dual profil inhibit collagenas hyaluronidas furthermor consid overal activ test compound prove promis anti age compound compound also show photo protect effect without cytotox human skin keratinocyt cell predict bind site target enzym comput studi also carri
|
D015595;D012871
|
T033;T047;T042
|
36,296,506
|
evalu polycycl aromat hydrocarbon smoke chees made poland hplc method smoke chees particular popular among consum flavor aroma interest therefor health aspect relat likelihood polycycl aromat hydrocarbon pah known carcinogen found smoke product thus purpos studi evalu occurr polycycl aromat hydrocarbon pah smoke non smoke chees purchas poland monitor safeti level select pah chees sampl determin use hplc dad fld method chees test met maximum level benzo pyren gkg sum benz anthracen chrysen benzo b fluoranthen benzo pyren gkg establish product howev chees studi work relat low amount sum compound compar inform avail chees literatur rang lt lod gkg amount pose health risk consum predomin pah found naphthalen phenanthren fluoren acenaphthen benzo pyren marker compound repres carcinogen pah found polish smoke non smoke chees respect although current regul smoke chees maximum concentr pah type food product control pah content chees import due mutagen carcinogen potenti chemic
|
D011084;D002611;D010616
|
T168;T121;T109
|
36,296,504
|
fabric character chitosan pea protein isol nanoparticl chitosan cs pea protein isol ppi use raw materi prepar nanoparticl structur function properti nanoparticl three ratio cs ppi evalu particl size chitosan pea protein isol cs ppi nanoparticl ratio nm respect signific differ analysi turbid endogen fluoresc spectroscopi fourier transform infrar spectroscopi interact cs ppi main caus electrostat mutual attract hydrogen bond term interfac properti contact angl nanoparticl ratio respect emulsifi activ eai nanoparticl relat proport protein nanoparticl ratio highest potenti best thermal stabil observ morpholog transmiss electron microscopi could seen nanoparticl ratio closest spheric studi provid theoret basi design cs ppi nanoparticl applic promot emuls stabil deliveri activ substanc use emuls
|
D048271;D000078724;D053758
|
T121;T073;T116;T109
|
36,296,503
|
triflamid allyl contain substanc unusu dehydrobromin vs intramolecular heterocycl allyl halid triflamid oxid condit form halogen substitut amidin allyl cyanid react triflamid acetonitril thf solut presenc nbs give product bromotriflamid solvent intercept wherea ch cl two regioisom bromotriflamid product without solvent intercept obtain form product undergo base induc dehydrobromin give linear isom new cc bond conjug either nitril group amidin moieti alkoxi group condit reaction allyl alcohol triflamid give rise amidin prepar earlier reaction diallyl formal triflamid unlik iodo substitut analog bromo substitut amidin success transform imidazolidin action potassium carbon
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D000578;D048289
|
T109
|
36,296,501
|
comput design synthesi pharmacolog evalu naproxen guaiacol chimera gastro spare anti inflammatori respons select cox inhibit allyl guaiacol natur phenol molecul wide studi antioxid capac reactiv oxygen speci mediat cellular damag therefor hypothes concomit use antioxid nsaid may decreas risk gastrointestin toxic make therapi safer address gastrointestin toxic convent nsaid new naproxen allyl guaiacol chimera mas comput develop chemic synthes test anti inflammatori effect gastrointestin safeti inhibitori potenc mas test cyclooxygenas cox lipoxygenas lox lipoxygenas lox vitro reveal stronger inhibit cox furthermor mas chimera increas cox select index compar parent compound naproxen impli higher efficaci gastric safeti vivo data show mas less like caus gastrointestin harm naproxen also exert anti inflammatori analges effect equival superior naproxen conclus mas oral activ bio labil crystallin make medic may administ oral
|
D005767;D009288
|
T121;T047;T109
|
36,296,500
|
design prepar evalu osthol poli butyl cyanoacryl nanoparticl improv vitro anticanc activ neuroblastoma treatment osthol osthol known neuroprotect drug shown potent anticanc activ howev potenti clinic applic osthol limit due low water solubl low bioavail polybutyl cyanoacryl pbca wide use improv solubl drug poor water solubl studi orthogon experiment design o appli design prepar process pbca nanoparticl nps nanoparticl prepar evalu term physicochem properti vitro releas cellular uptak etc anti cancer activ osthol pbca nps demonstr sh syy cell pharmacokinet area curv auc investig obtain osthol nps present spheric shape particl size nm polydispers index pdi zeta potenti mv compar free osthol drug osthol nps present better stabil sustain releas pattern activ vitro analysi use sh syy neuroblastoma cell show osthol load nanoparticl display signific enhanc intracellular absorpt process three time cytotox compar free osthol p lt increas vivo pharmacokinet studi reveal auc osthol nps fold higher free osthol conclus osthol pbca nps enhanc bioactiv osthol propos novel promis vehicl drug deliveri
|
D004659;D018696;D009447;D053758
|
T121;T073;T109;T191;T122;T169
|
36,296,499
|
sahlep dactylorhiza osmanica phytochem analys lc hrms molecular dock antioxid activ enzym inhibit profil studi shown invers correl among age relat ill like coronari heart diseas cancer intak fruit veget given probabl health benefit natur antioxid plant research increas dactylorhiza osmanica consum food tradit medicin plant region turkey evalu biolog abil speci import studi amount phenol content lc hrms antioxid activ enzym inhibitori properti endem plant osmanica investig antioxid capac ethanol extract osmanica aerial part edoa root edor evalu various antioxid method addit enzym inhibitori effect edoa edor examin acetylcholinesteras ach glycosidas amylas enzym associ common global alzheim diseas diabet mellitus ic valu edoa enzym found mgml respect ic valu edor enzym found mgml respect addit lc hrms analys reveal p coumar acid plenti phenol edoa mgg edor mgg furthermor molecular dock interact p coumar acid quercitrin vanil acid plenti phenol compound extract ach glucosidas amylas evalu use autodock vina softwar rich phenol content effect antioxid abil enzym inhibit potenti edoa edor may support plant widespread food tradit medicin use
|
D000975;D000520
|
T123;T121;T116;T126;T039;T044
|
36,296,498
|
integr metabolom lipidom strategi reveal action pattern paclobutrazol plant growth retard vari chemic constitu platycodon root platycodon root medicin food homolog speci use asian countri hundr year wide cultiv china treatment paclobutrazol typic plant growth retard rais uncertainti regard qualiti platycodon root rare investig present studi metabolom lipidom differ reveal ultra high perform liquid chromatographi coupl ion mobil quadrupol time flight mass spectrometri uplc im qtof ms signific decreas platycodigenin type saponin observ paclobutrazol treat sampl carri comprehens quantit analysi content total saponin saccharid determin illustr mode action paclobutrazol platycodon root studi demonstr exemplari research model explain exogen matter influenc chemic properti medicin plant therefor might provid insight reason applic plant growth regul
|
D031238;D012503
|
T002;T109
|
36,296,497
|
design synthesi crystal structur vitro silico evalu new n benzyliden tert butylbenzohydrazid deriv potent ureas inhibitor hydrazid play vital role make biolog activ compound various field chemistri determin antioxid antidepress antimalari anti inflammatori antiglyc antimicrobi activ present studi twenti three new n benzyliden tert butyl benzohydrazid deriv synthes condens aromat aldehyd commerci avail tert butyl benzoic acid target compound success synthes good excel yield synthes deriv character via spectroscop techniqu hrei ms h nmr synthes compound evalu vitro ureas inhibit synthes deriv demonstr good inhibitori activ rang ic compar standard thiourea ic two compound found activ standard sar reveal electron donat group phenyl ring influenc enzym inhibit howev gain insight particip differ substitu synthes deriv bind interact ureas enzym silico comput simul molecular model analysi carri
|
D014510;D000962
|
T121;T126;T116
|
36,296,496
|
novel coumarin carboxamidesulfonamid deriv potenti fungicid agent design synthesi biolog evalu coumarin compound varieti biolog activ anti tumor anti coagul anti hiv anti fungal insecticid amid sulfonamid compound use fungicid half centuri dozen varieti develop far studi focus introduct carboxamid sulfonamid moieti coumarin core discov novel deriv base strategi synthes two seri novel carboxamid sulfonamid substitut coumarin deriv fungicid activ also investig design compound possess potenti activ six phytopathogen fungi primari assay highlight compound r compound r exhibit stronger fungicid activ botryti cinerea ec gml lead structur studi
|
D005659
|
T131
|
36,296,495
|
cell cycl arrest apoptosi induc abil benzimidazol deriv design synthesi dock biolog evalu current studi new benzimidazol base oxadiazol deriv synthes character nmr ir ms element analysi final compound screen cytotox mda mb skov cell line egfr inhibitori activ compound found activ test cell line compar doxorubicin exhibit signific inhibit egfr kinas ic respect compar erlotinib ic furthermor two compound effect suppress cell cycl progress induc cell apoptosi mda mb skov cell line dock studi reveal compound show interact similar erlotinib egfr site conclud synthes molecul effect inhibit egfr arrest cell cycl may trigger apoptosi therefor could use lead molecul develop new anticanc agent target egfr kinas
|
D047428;D000970
|
T121;T116;T109
|
36,296,494
|
pharmacokinet herb drug interact glipizid andrographi paniculata burm f andrographolid normal diabet rat valid hplc method co administ medicin herb modifi drug pharmacokinet pk effect toxic andrographi paniculata burm f ethanol extract ape andrographolid potent cypc inducerinhibitor alter pharmacokinet paramet glipizid glz studi aim determin potenti pharmacokinet herb drug interact glz apeand plasma normal diabet rat use hplc bioanalysi method glipizid bioanalyt method establish rp hplcuv instrument valid follow ema guidelin glz administ alon combin ape normal diabet rat glz pharmacokinet paramet estim accord correl concentr sampl time use pk solver program simpl rapid glz bioanalysi techniqu lower limit quantit ngml develop present follow paramet accuraci error precis cv select stabil linear r concentr rang ngml ape administr signific improv c max auc auc glz valu normal diabet rat p lt signific reduc bioavail glz diabet rat small valu c max auc auc p lt combin consid administ medic influenc pharmacolog effect glz
|
D035685;D003921;D004224;D015186
|
T015;T050;T002;T109
|
36,296,493
|
multi analyt approach silver copper coin roman empir elucid economi rd centuri ad studi silver copper alloy denarii antoniniani rd centuri ad studi obtain overal chemic composit approach use characteris base combin physic chemic chemometr techniqu aim identifi quantifi major trace element roman silver copper coin order assess chang composit confirm devalu currenc first catalogu step edxrf sem edx techniqu perform identifi element coin surfac micro destruct sampl method employ repres sampl coin quantifi element present bulk powder obtain drill coin keep two categori coin separ dissolv acid medium heat sonic facilit dissolut analys icp ae icp ms two currenc differ averag alloy percentag particular differ ag element found concentr lt wt element highest concentr pb sn agreement literatur multivari analysi perform data acquir reveal two group coin correspond two currenc
|
D009717;D014131
|
T090;T121;T123;T073;T196
|
36,296,492
|
asymmetr synthesi contact sex pheromon tetropium fuscum enantiom tetropium fuscum harm forest pest attack spruce contact sex pheromon pest methyl heptacosan enantiom synthes via evan chiral auxiliari key step approach includ acyl carboxyl acid diastereoselect methyl oxazolidinon amid wittig coupl aldehyd chiral phosphonium salt synthet pheromon would potenti util control pest
|
D012724;D001517
|
T123;T204
|
36,296,491
|
antibacteri antiparasit activ propyl propan thiosulfin pts propyl propan thiosulfon ptso allium cepa gilthead sea bream pathogen vitro vivo studi use phytogen extract consid sustain strategi prevent fish diseas includ alliacea potenti option due varieti bioactiv compound studi analyz antibacteri antiparasit potenti propyl propan thiosulfin pts propyl propan thiosulfon ptso onion vitro activ pseudomona anguilliseptica tenacibaculum maritimum photobacterium damsela compound test addit viabil sparicotyl chrysophrii larva evalu moreov diet consist blend ptsptso allium use total gilthead sea bream juvenil test p damsela subsp piscicida week dietari administr furthermor fish rate parasitesfish fed day number gill parasit record strain sensit compound ptso show highest inhibitori effect target strain pts show higher effect chrysophrii fish allium group present highest probabl surviv increas wherea control group probabl surviv number parasit gilthead sea bream decreas allium group time result suggest inclus pts ptso feed natur strategi prevent antibacteri antiparasit fish diseas
|
D021541;D000490;D005393
|
T047;T002;T013
|
36,296,490
|
diastereoselect synthesi high function prolin deriv effici way access high function prolin deriv develop base cu catalyz reaction cf substitut allenyn tosylazid involv cascad cycloadditionketenimin rearrangementald ene cyclize afford new prolin framework high diastereoselect
|
D011392
|
T123;T116
|
36,296,489
|
evalu key structur featur various butyrylcholinesteras inhibitor use simpl molecular descriptor studi develop sever qsar model base simpl descriptor topolog constitut estim butyrylcholinesteras bche inhibit potenc p k pic set exclus outlier structur differ compound model similar best model obtain previous acetylcholinesteras ach base valenc molecular connect indic second third order v v number aliphat hydroxyl group noh alogp ghose crippen octanol water partit coeff logp atom centr fragment al ar ar ar r r r cx best model two three descriptor yield r se r se respect also correl nine score function calcul ligand whose complex bche found protein data bank crystal structur p k pic best correl yield plp plp piecewis linear pairwis potenti function r respect correl certain simpl topolog constitut descriptor yield better result eg v r set compound n
|
D002091;D000110
|
T126;T116
|
36,296,488
|
molybdenum cofactor defici human molybdenum cofactor moco defici mocd character neonat onset myoclon epilept encephalopathi dystonia cerebr mri chang similar hypox ischem lesion molecular caus diseas loss sulfit oxidas sox activ one four moco depend enzym men accumul toxic sulfit caus secondari increas metabolit sulfocystein thiosulf well decreas cystein oxid form cystin moco synthes three step biosynthet pathway involv gene product moc moc moc gphn depend synthet step impair mocd classifi type b c distinct relev patient manag metabol block mocd type circumv administ cyclic pyranopterin monophosph cpmp substitut therapi cpmp high effect reduc sulfit toxic restor biochem homeostasi clinic outcom critic depend degre brain injuri prior start treatment absenc specif treatment mocd type bc sox defici summar recent progress understand under metabol chang cystein homeostasi propos novel therapeut intervent circumv patholog chang
|
D008667;D050876;D001927
|
T123;T047;T126;T116
|
36,296,487
|
antihypertens activ alkaloid aspidocarpin normotens wistar rat alkaloid aspidocarpin isol bark aspidosperma desmanthum structur elucid spectral data h c nmr high resolut mass spectrometri hresim antihypertens activ investig intraven infus wistar rat alkaloid signific reduc p lt systol median diastol blood pressur rodent without caus motor incoordin imbal rotarod test result indic alkaloid aspidocarpin exert antihypertens activ without caus sedat impair motor function
|
D030009;D000470
|
T123;T121;T109;T131;T002
|
36,296,486
|
isol phenol compound raspberri base molecular imprint techniqu investig anti alzheim diseas properti alzheim diseas common neurodegen diseas character memori loss cognit dysfunct raspberri fruit contain polyphenol antioxid anti inflammatori properti studi use molecular imprint technolog effici isol phenol compon raspberri ethyl acet extract six phenol compon ellag acid tilirosid kaempferol rutosid gallic acid ferul acid vanil acid identifi uplc q tof ms analysi molecular dock use predict anti inflammatori effect anti alzheim potenti isol compound show good bind abil diseas relat protein howev bind energi dock fraction ellag acid tilirosid kaempferol rutosid better gallic acid ferul acid vanil acid addit studi effect six phenol compon lps induc secret inflammatori mediat murin microgli bv cell demonstr capabl inhibit secret il tnf il certain extent howev ellag acid tilirosid kaempferol rutosid better inhibitori effect compar other result obtain suggest phenol compon extract ethyl acet extract raspberri molecular imprint polym potenti inhibit progress alzheim diseas
|
D065856;D054802;D019636
|
T063;T129;T168;T047;T002
|
36,296,485
|
antifung activ amphiphil perylen bisimid perylen base compound either natur occur synthet shown interest biolog activ studi report broad spectrum antifung properti two lead amphiphil perylen bisimid compound synthes perylen tetracarboxyl dianhydrid condens spermin ammonium salt format antifung activ evalu use collect fungal strain clinic isol patient onychomycosi sporotrichosi molecul display interest antifung profil mic valu rang activ sever refer drug even potent particular strain ammonium trifluoroacet salt show highest activ mic valu test candida spp two cryptococcus spp two fusarium spp one neoscytalidium spp strain therefor amphiphil molecul perylen moieti cation ammonium side chain repres import structur featur develop novel antifung
|
D010569;D064751
|
T109;T131;T197;T104;T130
|
36,296,484
|
indigen saccharomyc cerevisia could better adapt physicochem condit natur microbi ecolog princ grape must compar commerci saccharomyc cerevisia fx indigen saccharomyc cerevisia new use tool use ferment enhanc aroma characterist qualiti wine product region studi use indigen cerevisia l commerci cerevisia fx ferment princ new hybrid varieti lion wineri wine detect basic physicochem paramet dynam chang fungal communiti ferment analyz correl fungal communiti volatil compound result show indigen cerevisia l could quick adapt specif physicochem condit microbi ecolog grape must show strong potenti winemak compar commerci cerevisia fx wine ferment indigen cerevisia l contain glycerol less organ acid contribut rounder tast result volatil compound indic indigen cerevisia l posit effect ad rosi honey pineappl sweet aroma characterist wine overal studi perform show select indigen cerevisia wine produc region starter wine ferment conduc improv aroma profil wine preserv aroma grape varieti
|
D027843;D014920
|
T129;T168;T116;T002
|
36,296,483
|
energi crop methan process optim ca oh assist thermal pretreat model methan product switchgrass earn place global signific energi crop possess essenti properti abl control eros low cost product biomass rich appeal biofuel product studi impact ca oh assist thermal pretreat process switchgrass varieti shawne methan fuel product investig ca oh assist thermal pretreat process optim enhanc methan product potenti switchgrass solid load ca oh concentr reaction temperatur c reaction time h select independ variabl optim methan product obtain ml ch gvs optim pretreat condit specif reaction temperatur c reaction time h ca oh solid load compar raw switchgrass methan product enhanc addit chang surfac properti bond structur along kinet paramet first order cone reaction curv modifi gompertz model reveal import optim
|
D008697;D008897
|
T002;T109
|
36,296,482
|
bis oxiran contain cyclooctan core synthesi reactiv toward nan reaction oxiran ring open provid power tool regio stereoselect synthesi polyfunct heterocycl compound wide use organ chemistri drug design cyclooctan alongsid medium size ring interest novel molecular platform construct target orient lead addit cyclooctan deriv well known prone transannular reaction make promis object search novel approach polycycl structur present work seri cyclooctanedion studi corey chaykovski reaction novel spirocycl bis oxiran contain cyclooctan core name dioxadispiro dodecan dioxadispiro dodecan synthes ring open obtain bis oxiran upon treatment sodium azid investig found reaction path determin reciproc orient oxygen atom oxiran moieti diastereom bis oxiran cis orient underw independ ring open suppli correspond diazidodiol case stereoisom tran orient domino like reaction occur includ intramolecular nucleophil attack format novel three six member contain ring summarili straightforward approach polyfunct compound contain cyclooctan oxabicyclo nonan core employ bis oxiran elabor
|
D005027;D004852
|
T131;T109
|
36,296,481
|
comprehens biolog potenti phytochem profil use gc ms lc esi ms silico assess strobilanth glutinosus nee import medicin plant plant genus strobilanth notabl use folklor medicin well use pharmacolog purpos present work explor biolog predisposit strobilanth glutinosus attempt accomplish comprehens chemic profil gc ms differ fraction concern polar chloroform n butanol lc esi ms methanol extract posit negat ionize mode biolog characterist antioxid potenti assess appli six differ method potenti clinic relev enzym amylas glucosidas tyrosinas inhibit examin dpph abt cuprac frap result reveal methanol fraction present effici result phosphomolybdenum assay reveal n hexan fraction show effici result maximum metal chelat potenti observ chloroform fraction gc ms profil n butanol chloroform fraction reveal exist sever import compound present differ class fatti acid phenol alkan monoterpen diterpen sesquiterpenoid sterol lc esi ms tentat identifi presenc clinic import secondari metabolit n hexan fraction exhibit highest potenti amylas mm acaeg extract glucosidas mm acaeg extract signific inhibitori activ tyrosinas enzym display fraction six prevail compound gc ms studi lupeol beta amyrin stigmasterol gamma sitosterol octadecadieno acid n hexadecano acid model glucosidas amylas enzym along comparison bind affin standard acarbos three compound identifi lc esi ms dock mushroom tyrosinas enzym present signific bide affin thus assum glutinosus demonstr effect antioxid enzym inhibit prospect effect bioactiv molecul potenti open door new applic field medicin
|
D010946
|
T002
|
36,296,480
|
new cycloadditon reaction chloroprop enethioamid dialkyl acetylenedicarboxyl synthesi dialkyl bis alkoxycarbonyl aryl alkyl imino h thienyliden dithiol dicarboxyl dipolar cycloaddit dithiol thion alkyn form dithiol one studi reaction class polysulfur contain heterocycl nucleophil substitut chlorin atom dimethyl dichloro thioxoethyliden dithiol dicarboxyl obtain addit one molecul dmad dichloro h dithiol thion led seri chloro dithiol yliden ethanethioamid cycloaddit reaction chloro dithiol yliden ethanethioamid activ alkyn led unexpect format thiophen h yliden dithiol via new intermedi dithiol yliden n phenylethan yliumimidothio structur dimethyl bis methoxycarbonyl phenylimino thiophen h yliden dithiol dicarboxyl final proven singl crystal x ray diffract studi optim reaction condit mechanist rational dipolar cycloaddit novel intermedi present
|
D013871;D002713
|
T131;T196;T197;T109
|
36,296,479
|
plant yeast advanc biosynthesi artemisinin malaria life threaten diseas artemisinin base combin therapi act prefer choic malaria treatment recommend world health organ present main sourc artemisinin extract artemisia annua howev artemisinin content annua meet global demand meanwhil chemic synthesi artemisinin disadvantag complic step high cost low yield therefor applic synthet biolog approach produc artemisinin vivo magnific prospect review biosynthesi pathway artemisinin summar discuss advanc heterolog biosynthesi artemisinin use microorgan escherichia coli saccharomyc cerevisia chassi cell yeast cell factori product artemisinin transfer plant yeast optim ferment process yield artemisin acid reach gl therebi produc semi synthesi artemisinin moreov review genet engin annua improv artemisinin content includ overexpress artemisinin biosynthesi pathway gene block key gene competit pathway regul express transcript factor relat artemisinin biosynthesi final research progress artemisinin product plant nicotiana physcomitrella etc discuss current advanc artemisinin biosynthesi may help lay foundat remark regul artemisinin product annua gene edit molecular design breed futur
|
D000962;D037621;D031172;D008288
|
T121;T047;T002;T109
|
36,296,478
|
novel type tetranitrosyl iron salt synthesi structur antibacteri activ complex fel fel l l thiobenzamid l thiosulf work new donor nitric oxid antibacteri properti name nitrosyl iron complex fe c h c snh fe c h c snh composit complex synthes studi complex produc reduct aqueous solut fe dianion thiosulf treatment mixtur acidifi alcohol solut thiobenzamid base structur studi x ray analysi quantum chemic calcul nbo qtaim method frame dft data obtain presenc nono interact stabil dnic dimer solid phase conform properti electron structur free energi complex hydrat studi use blyp function set g p basi function effect aquat surround taken account frame polar continu model pcm donat activ complex studi amperometri method use amino sensor electrod inno nitric oxid measur system antibacteri activ studi gram negat escherichia coli gram posit micrococcus luteus bacteria cytotox studi use vero cell complex found exhibit antibacteri activ compar antibiot moder toxic vero cell
|
D009569;D058085
|
T121;T197;T104
|
36,296,477
|
pacdock web server posit distanc base interact base analysi dock result molecular dock key method structur base drug design use predict conform assum small drug like ligand bound target howev evalu molecular dock studi hamper lack free easi use platform complet analysi result obtain princip dock program aim develop pacdock freeli avail user friend web server compris collect tool posit distanc base interact base analysi dock result provid sever file format pacdock allow complet analysi molecular dock result root mean squar deviat rmsd calcul molecular visual cluster analysi dock pose rmsd calcul compar dock structur refer structur also atom random label conform posit differ visualis addit possibl visualis ligand target bind pocket investig key receptor ligand interact moreov pacdock enabl cluster dock result identifi restrain number cluster mani dock pose believ pacdock contribut facilit analysi dock result improv effici comput aid drug design
|
D003201
|
T073
|
36,296,476
|
valor fli ash sand wast biomass boiler one part geopolym fli ash fa exhaust bed sand sand wast generat biomass burner energi product two wast generat pulp paper industri worldwid product fa biomass estim million tonsyear expect increas context present work aim develop one part alkali activ materi biomass fa wt binder sand wast wt aggreg fa two differ boiler ca ct character mortar properti fresh harden condit evalu overal incorpor fa decreas compress strength specimen howev valu higher mpa reach wt fa incorpor ca ct compress strength mortar day cure mpa wt mpa wt mpa wt mpa wt mpa wt respect evalu characterist densiti water absorpt leach compon freez thaw resist show signific differ except specimen wt ca therefor work prove one part geopolymer materi wt pulp paper industri residu fa sand produc thus reduc carbon footprint associ construct sector
|
D060729;D000080463
|
T131;T197;T130;T109
|
36,296,474
|
systemat ingredi investig ficus tikoua bur fruit immunoregulatori antioxid effect differ fraction although fruit ficus tikoua bur consum montan peopl china centuri chemic biolog composit still unclear seri comprehens investig chemic constitu bioactiv carri first time result six compound isol identifi main compon fruit gc ms analysi lipid compon demonstr ficus tikoua bur fruit contain wholesom constitu fatti acid vitamin triterpenoid phytosterol fatti acid main compos linolen acid linol acid furthermor fruit contain relat high content crude protein total amino acid total polyphenol g g analysi monosaccharid composit show total polysaccharid main consist glucos glucuron acid xylos arabinos mannos galactos galacturon acid rhamnos polysaccharid polyphenol water ethanol flavonoid extract exhibit promin antioxid activ determin abt dpph frap method meanwhil total polysaccharid exhibit signific immunomodulatori effect enhanc releas cytokin express ino cox raw cell signific decreas express c jun p protein cytoplasm increas transloc c jun p nucleus regul phosphoryl level akt pik pdk pikakt signal pathway studi prove fruit f tikoua reliabl sourc function food
|
D030681;D014315;D010840
|
T121;T123;T109;T168;T002
|
36,296,473
|
synthesi phenylboron acid function magnet nanoparticl sensit soil enzym assay soil enzym invertas ureas acid phosphatas catalas play critic role soil biochem reaction involv soil fertil howev remain great challeng effici concentr soil enzym sensit assess enzym activ studi synthes phenylboron acid function magnet nanoparticl rapid captur soil enzym sensit soil enzym assay iron oxid magnet nanoparticl mnps first prepar co precipit method function aminopropyl triethoxysilan polyethyleneimin phenylbor acid turn obtain final nanoparticl mnppba protein captur assay show function mnps much higher protein captur capac nake mnps versus moreov mnppba almost thorough captur test enzym ie ureas invertas alkalin phosphatas enzym solut base mnppba soil enzym assay method develop integr enzym captur magnet separ trace enzym analysi method success appli determin trace enzym activ rhizospher soil studi provid strategi sensit determin soil enzym activ mechanist investig soil fertil plant microbiom interact
|
D012987;D058185
|
T130;T167
|
36,296,472
|
synthesi photophys properti n biphenyl substitut bipyridin base push pull fluorophor seri new n biphenyl substitut bipyridin obtain combin ipso nucleophil aromat substitut c cyano group aza diel alder suzuki cross coupl reaction start cyano triazin obtain compound photophys fluorosolvatochrom properti studi fluorophor l b demonstr unexpect aiee activ h show promis nitroexplos detect abil
|
D015082;D005456
|
T130;T109
|
36,296,471
|
chemic synthesi tran methyl nonenoyl coa function express unravel capsaicin synthas activ encod pun locus capsaicin produc divers capsicum speci among world popular spice consider pharmaceut relev although capsaicinoid biosynthet pathway investig decad sever biosynthet step remain part hypothet genet evid suggest decis capsaicin synthas encod pun locus yet genet evid pun locus never corrobor function activ capsaicin synthas presum catalyz amid bond format tran methyl nonenoyl coa deriv branch chain amino acid biosynthesi vanilloylamin deriv phenylpropanoid pathway report demonstr enzymat activ recombin capsaicin synthas encod pun function express escherichia coli provid inform substrat specif catalyt properti recombin capsaicin synthas specif select aliphat coa ester high specif vanilloylamin part purifi e coli recombin activ enzym monomer protein kda independ addit co factor associ protein previous propos data use design capsaicin synthas variant differ properti altern substrat prefer
|
D002211;D029968
|
T121;T116;T109
|
36,296,470
|
revisit nutrit chemic biolog potenti cajanus cajan l millsp genus cajanus famili fabacea consist approxim speci cajanus cajan c cajan signific member genus commerci legum crop wide grown sub tropic semi arid tropic area world c cajan well known folk medicin use treat various disord toothach dizzi diabet stomachach femal ailment chronic infect properti link presenc sever valu ad nutrit bioactiv compon differ solvent extract c cajan leav root stem seed evalu phytochem biolog activ name antioxid antimicrobi antidiabet neuroprotect anti inflammatori effect taken togeth consid promin nutraceut therapeut properti c cajan review articl focus import detail includ ethnomedicin use chemic composit biolog applic medicin aspect relat c cajan nutraceut pharmacolog applic
|
D036561;D007887
|
T002
|
36,296,469
|
synthesi biolog activ novel oxazinyl flavonoid antivir anti phytopathogen fungus agent seri oxazinyl flavonoid synthes basi flavon structur target compound character h nmr c nmr hrms effect differ substitu n posit oxazinyl flavonoid tobacco mosaic virus tmv activ plant pathogen activ systemat investig vivo anti tmv activ show compound show moder excel antivir activ tmv gml compound b j k n q show better antivir activ ribavirin commerci avail antivir agent apigenin particular compound n p even display slight higher activ ningnanmycin expect becom new antivir candid antivir mechan research molecular dock exhibit compound n p could interact tmv cp inhibit virus assembl antifung activ compound six kind plant pathogen fungi test result show oxazinyl flavonoid broad spectrum fungicid activ compound h exhibit antifung activ physalospora piricola might becom candid drug new fungicid
|
D005659;D000470;D014027
|
T121;T123;T109;T131;T005
|
36,296,468
|
brazilian agroindustri wast potenti resourc bioativ compound antimicrobi antioxid activ studi recoveri bioactiv compound natur resourc implic sever area signific scientif communiti work aim studi brazilian agroindustri wast antioxid antimicrobi activ use green extract oliv leav jaboticaba peel ara peel pecan nut shell evalu four condit convect dri aqueous extract convect dri ethanol extract freez dri aqueous extract freez dri ethanol extract result demonstr sampl show high antioxid potenti highest antioxid activ obtain extract pecan nut shell quantif compound hplc oliv leaf present highest content phenol compound extract main oleuropein final antimicrobi activ analysi reveal extract bactericid potenti staphylococcus aureus escherichia coli present studi show green extract extract bioactiv compound antioxid antimicrobi properti highlight import choos dri method solvent futur use natur resourc industri
|
D000975;D000890
|
T123;T039;T121;T044
|
36,296,467
|
analysi antimicrobi anti biofilm activ natur compound analogu staphylococcus aureus isol background staphylococcus aureus aureus one frequent caus biofilm associ infect emerg antibiot resist especi methicillin resist aureus mrsa urgent need discov novel inhibitori compound clinic import pathogen studi evalu antimicrobi anti biofilm activ compound includ phenyl propen phenol aldehyd eugenol ferul acid sinap acid salicylaldehyd vanillin cinnamoyl acid aldehyd drug resist aureus isol method thirti two clinic aureus isol obtain alkhidmat diagnost center blood bank karachi pakistan screen biofilm form potenti susceptibilityresist ciprofloxacin chloramphenicol ampicillin amikacin cephalothin clindamycin streptomycin gentamicin use kirbi bauer disk diffus method subsequ repres clinic isol select use test antimicrobi anti biofilm potenti compound use qualit quantit assay follow qpcr analysi examin differ express level biofilm form gene ica fnb b clf cna treat natur compound deriv untreat isol result isol found multi drug resist domin biofilm former individu minimum inhibitori concentr mic natur compound analogu rang mgml furthermor compound salicylaldehyd sali vanillin van methyl tran cinnamaldehyd mt tran nitrocinnam acid tn exhibit signific biofilm inhibitionreduct percentag capac concentr mgml gene express analysi show salicylaldehyd methyl tran cinnamaldehyd bromo tran cinnamaldehyd result signific p lt downregul express ica clf fnb gene compar untreat resist isol conclus natur compound analogu use studi exhibit signific antimicrobi anti biofilm activ aureus biofilm persist main concern clinic set compound may serv potenti candid drug molecul biofilm form aureus
|
D055624;D013203
|
T047;T007
|
36,296,466
|
atom econom multi substitut pyrrol synthesi aziridin multi substitut pyrrol synthes regiospecif aziridin ring open subsequ intramolecular cyclize carbonyl group posit presenc lewi acid protic acid method high atom econom atom reactant incorpor final product remov water new protocol appli synthesi various pyrrol includ natur product
|
D001388;D001688
|
T123;T121;T109
|
36,296,464
|
wearabl capacit pressur sensor contact non contact sens puls waveform monitor sensit flexibl pressur sensor invok consider interest broad rang applic tactil sens physiolog sens flexibl electron barrier high sensit low fabric cost need address commerci flexibl pressur sensor low cost sacrifici templat assist method capacit sensor report herein util porous polydimethylsiloxan pdms polym multiwal carbon nanotub mwcnt composit base dielectr layer sensor show high sensit kpa along low limit detect pa high sensit origin ad mwcnt pdms increas composit polym dielectr constant besid pressur sensor show excel stabil cyclic load cycl prove reliabl long last applic tactil physiolog sens high sensit sensor suitabl detect small deform puls waveform well tactil pressur sens addit paper demonstr simultan contact non contact sens capabl suitabl dual sens pressur proxim singl data readout system dual mode sens capabl may open opportun realiz compact system robot gestur control contactless applic mani practic sensor shown applic tactil sens mors code generat proxim sens puls wave sens
|
D000076251;D037742
|
T104;T073
|
36,296,463
|
biosynthesi relat enzym structur divers bioactiv abund indol diterpen review indol diterpen larg class secondari metabolit produc fungi possess cyclic diterpenoid backbon indol moieti novel structur import biolog activ made indol diterpen one focus synthet chemist although discoveri identif structur divers biolog activ especi structur activ relationship indol diterpen report paper recent year absent systemat comprehens analysi elucid enzym relat kind natur product therefor necessari summar relev report provid new perspect follow research review first time function relat synthas structur activ relationship indol diterpen expound recent research advanc emphas
|
D004224;D001688
|
T123;T121;T109
|
36,296,462
|
nanocomposit nickel nanoparticl impregn biochar palm leav high activ magnet photocatalyst methyl violet photocatalyt oxid photocatalysi recogn feasibl method water wastewat treatment compar method adsorpt chemic oxid use photocatalyst advanc oxid process give benefit longer lifetim catalyst less consum chemic current explor low cost effect photocatalyst organ contamin water develop within scheme easili separ photocatalyst function high adsorpt import research prepar magnet nanocomposit photocatalyst base agricultur wast palm leav biochar impregn nickel nanoparticl nibc investig nanocomposit prepar direct pyrolysi palm leav impregn nickel ii chlorid precursor furthermor physicochem character materi perform use x ray diffractomet xrd scan electron microscopi energi dispers x ray fluoresc sem edx transmiss electron microscopi tem gas sorption analysi x ray photoelectron spectroscopi xps vibrat sampl magnetomet vsm photocatalyt activ nibc evalu methyl violet mv photocatalyt oxid result xrd xps tem analys identifi singl nickel nanoparticl dispers biochar structur rang nm size dispers nickel nanoparticl increas bet specif surfac area biochar g g oxid high photocatalyt activ nibc exhibit complet mv remov min concentr rang mgl addit nibc show stabil ph rang reusabl without activ chang fifth usag separ photocatalyst relat magnet emug result highlight role biochar effect support ni photoact materi
|
D053761;D053758
|
T073
|
36,296,460
|
rubus cap zinc oxid nanoparticl induc apoptosi mcf breast cancer cell rubus fairholmianus rf wide use treat various ailment includ pain diabet cancer zinc oxid nanoparticl zno nps drawn attent modern healthcar applic henc design studi synthes zinc oxid zno nanoparticl use r fairholmianus root extract investig synergist cytotox effect mcf cell explor possibl cell death mechan zno nps synthes via green synthesi use r fairholmianus root extract effect mcf cell determin look cellular morpholog prolifer cytotox apoptosi reactiv oxygen speci ros result show cellular prolifer reduc follow treatment r fairholmianus cap zinc oxid nanoparticl rfzno nps cytotox ros increas also increas apoptosi indic signific increas cytoplasm cytochrom c caspas marker apoptosi well increas level pro apoptot protein p bax decreas level anti apoptot protein bcl conclus result show rfzno nps induc apoptosi breast cancer cell via mitochondria mediat caspas depend apoptot pathway suggest use aceton root extract r fairholmianus treatment cancer relat ailment
|
D015034;D065856;D001943;D053758;D053768
|
T129;T121;T073;T168;T197;T191;T002
|
36,296,459
|
effect amino acid folat accumul wheat seedl germin red light radiat defici folat caus various health problem germin potenti way enrich folat grain base food materi present studi effect six amino acid phenylalanin tyrosin tryptophan glutam aminobutyr acid p aminobenzo acid folat accumul wheat germin red light radiat investig optim combin amino acid promot folat enrich establish result show appli phenylalanin tyrosin tryptophan glutam p aminobenzo acid wheat seedl germin signific increas content total folat activ synthesi precursor folat synthesi pterin p aminobenzo acid condens two moieti meanwhil regul correspond gene observ measur express investig mechan promot accumul folat highest content folat ca g g dw observ germin wheat cultur mixtur mm phenylalanin mm tyrosin mm tryptophan mm p aminobenzo acid mm glutam acid higher control seedl studi establish promis practic approach enhanc accumul folat wheat seedl
|
D018525;D036226
|
T168;T002;T038
|
36,296,458
|
volatil organ compound fragment afterglow puls glow discharg ambient air glow discharg gd sourc gain increas level attent relat analysi volatil organ compound voc sinc past work show soft ionize method allow direct analysi voc minim fragment howev issu fragment previous studi detail aim present work investig effect discharg condit voc fragment system consist cell puls glow discharg time flight mass spectromet ionize voc differ class hydrocarbon alcohol ester carboxyl acid investig copper cathod flat geometri use voc ioniz afterglow short puls glow discharg air use discharg afterglow signific reduc elimin effect ionize mechan pen process particular electron ionize signific reduc voc fragment provid rather low limit detect specif cluster format observ alcohol ester may facilit identif
|
D055549
|
T109
|
36,296,457
|
investig complex reaction pathway network isobutan buten alkyl cgc fid cgc ms ds mechan reaction isobutan buten alkyl system extrem complic accompani numer side reaction therefor comprehens understand reaction pathway system essenti depth discuss reaction mechan improv select major product clean fuel blend compon alkyl isobutan buten studi use self made intermitt reaction devic meter cool reaction vacuum analysi system alkyl qualit quantit analyz use capillari gas chromatographi mass spectrometri data system cgc ms ds capillari gas chromatographi flame ionize detect ccgc fid respect precis recoveri quantit analyt method verifi result show relat standard deviat rsd standard sampl recoveri specifi reaction condit volatil substanc identifi alkyl select c trimethylpentan tmps reach respect chang main chemic compon alkyl reaction time track analyz base reaction pathway determin complex reaction network contain main product product generat pathway construct
|
D002073;D000078327
|
T121;T170;T073;T109
|
36,296,456
|
antimicrobi activ silver gold nanoparticl prepar photoreduct process leav fruit extract plinia cauliflora punica granatum increas number resist microb generat search new antibiot method metal nanoparticl emerg new platform sever microorgan nanoparticl damag bacteria membran dna oxid stress photoreduct process clean low cost method obtain silver gold nanoparticl work describ two origin insight use extract leav fruit brazilian plant plinia cauliflora compar well know plant punica granatum use phytochem stabil agent photoreduct process prepar nanoparticl character uv vis ftir transmiss electron microscopi zeta potenti antimicrobi activ nanoparticl obtain gram negat gram posit bacteria particular pathogen staphylococcus aureus atcc bacillus subtili atcc clinic isol methicillin resist staphylococcus aureus mrsa enterococcus faecali escherichia coli atcc escherichia coli h eaec clinic isol klebsiella pneumonia atcc salmonella thiphymurium atcc pseudomona aeruginosa atcc candida albican atcc excel synthesi result obtain agnp exhibit antimicrobi activ gram negat gram posit bacteria yeast better aunp may potenti use antimicrobi agent
|
D053768;D000079702;D055624;D000890;D029561;D027822
|
T121;T007;T073;T109;T002
|
36,296,455
|
synthesi evalu diethyl benzylphosphon potenti antimicrobi agent impact substitu phenyl ring diethyl benzylphosphon deriv cytotox activ studi organophosphon obtain base develop palladium catalyz homodiaryl vinyl ester protocol new synthet pathway toward bis diethoxyphosphoryl methyl phenyl ethyl acet propos signific improv overal yield final product sever newli synthes organophosphon test new potenti antimicrobi drug model escherichia coli bacteri strain k r r test compound show highest select activ k r strain preliminari cellular studi use mic mbc test digest fpg modif bacteri dna suggest select benzylphosphon deriv may greater potenti antibacteri agent typic use antibiot ciprofloxacin bleomycin cloxacillin compound high specif pathogen e coli strain base model strain use may engag futur new substitut common use antibiot especi import due increas resist bacteria various drug antibiot
|
D000890;D063065
|
T121;T131;T109
|
36,296,454
|
uniqu porous c n nanotub electrochemiluminesc high emiss intens long term stabil role calcin atmospher develop excel strategi optim electrochemiluminesc ecl perform c n materi remain challeng due electrod passiv caus weak unstabl light emiss strategi control calcin atmospher propos improv ecl perform c n nanotub interest found calcin atmospher play key role specif surfac area pore size crystallin c n nanotub c n nanotub prepar air atmospher c n nt air possess larger specif surfac area smaller pore size better crystallin crucial improv ecl properti therefor c n exciton could produc c n nt air react electrochem reaction great increas ecl signal furthermor c n nanotubek system propos sens platform offer high sensit good select detect cu wide linear rang nm nm low detect limit nm
|
D006108;D015374;D043942
|
T073;T075;T109;T196;T059
|
36,296,453
|
conform stabil denatur process protein investig electrophoresi extrem condit function structur protein result margin stabl fold conform revers unfold irrevers denatur deterior caus chemic physic agent due chang physicochem condit ph ionic strength temperatur pressur electr field due presenc cosolv perturb delic balanc stabil destabil interact eventu induc chemic modif protein denatur complex process involv transient intermedi sever revers eventu irrevers step knowledg protein stabil denatur process mandatori develop enzym industri catalyst biopharmaceut analyt medic bioreag safe industri food electrophoresi techniqu oper extrem condit conveni tool analyz unfold transit trap transient intermedi gain insight mechan denatur process moreov quantit analysi electrophoret mobil transit curv allow estim conform stabil protein approach includ polyacrylamid gel electrophoresi capillari zone electrophoresi cold heat hydrostat pressur presenc non ionic denatur agent stabil polyol heavi water last exposur extrem physic condit electrophoresi standard condit provid inform irrevers process slow conform drift slow renatur process impress develop enzym technolog multipl applic fine chemistri biopharmaceut nanomedicin prompt us revisit potenti electrophoret approach featur review illustr publish unpublish result obtain author cholinesteras paraoxonas two physiolog toxicolog import enzym
|
D043303;D001688
|
T123;T121;T126;T116
|
36,296,452
|
synthesi novel indol schiff base compound antifung activ seri novel indol schiff base deriv contain thiadiazol scaffold modifi thioether group synthes structur confirm use ft ir h nmr c nmr hr ms addit antifung activ synthes indol deriv investig fusarium graminearum f graminearum fusarium oxysporum f oxysporum fusarium moniliform f moniliform curvularia lunata c lunata phytophthora parasitica var nicotiana p p var nicotiana use mycelium growth rate method among synthes indol deriv compound j show highest inhibit rate concentr gml f graminearum f oxysporum f moniliform p p var nicotiana respect similar compound j q exhibit higher inhibit rate concentr gml c lunata addit compound j recogn potenti compound investig field fungicid
|
D005659;D005670
|
T131;T004
|
36,296,451
|
migrat microplast phthalat face mask water sinc outbreak covid face mask introduc complex strategi infect prevent control face mask consist plastic polym addit phthalat aim studi evalu migrat microplast mp phthalat face mask water four type mask includ ffp mask surgic studi mask first character determin differ layer materi use fabric mask cut piec cm includ layer place water migrat mp phthalat evalu accord condit state eu regul plastic materi articl intend come contact food mp morpholog analysi shape dimens particl count perform use stereomicroscop identif mask mp releas conduct use fourier transform infrar spectroscopi ft ir migrat phthalat assess ultra high perform liquid chromatographi coupl tripl quadrupol mass spectromet uplc msms face mask analyz present studi made atact polypropylen pp state manufactur ft ir confirm pp polyamid pa releas fragment pp polyest pes releas fiber addit phthalat identifi concentr gmask studi show migrat studi appli evalu potenti releas mp phthalat face mask water could give hint potenti impact incorrect dispos aquat resourc
|
D000080545;D000086382
|
T122;T067;T047
|
36,296,450
|
leaf like structur zif l embed electrochem reduc graphen oxid composit electrochem sens platform sensit detect benomyl work two dimension leaf like framework l embed electrochem reduc graphen oxid ergo zif l propos outstand electrod materi sensit electrochem sens benomyl bm zif l surround ergo could effect ensur stabil dispers zif l uniqu combin prepar ergo zif l display excel synergist characterist larg surfac area excel conduct plenti activ site high electrocatalyt properti thus endow high sensit bm determin experiment paramet solut ph materi volum accumul time optim optim condit bm sensor show wide linear rang low limit detect nm moreov sensor display excel stabil repeat reproduc good anti interfer capabl method success appli detect bm real world sampl
|
D001542;D006108
|
T131;T196;T109
|
36,296,449
|
treatment liquid digest green algal isol artifici eutroph pond abil aquat microalga treat liquid digest obtain anaerob digest plant wast investig microalga isol natur environ laboratori scale cultiv use remov nutrient organ contamin liquid digest shown microalga consortia tetradesmus obliquus microglena sp desmodesmus subspicatus could reduc nitrogen phosphat total cod respect new alga genus microglena isol consortium tetradesmus obliquus desmodesmus subspicatus exhibit high effici remov organ contamin nutrient liquid fraction digest
|
D000460;D058086
|
T204;T002
|
36,296,448
|
enhanc photo thermal stabil nicotin crystal engin gentis acid use crystal engin convert liquid crystallin solid remain power method inhibit undesir degrad pathway nicotin liquid sensit light air combin gras list compound gentis acid result crystallin solid exhibit enhanc photo thermal stabil despit modest c melt point c nicotinium gentis salt highest report nicotin contain crystallin solid analysi crystal pack thermodynam properti provid context observ properti
|
D009538;D005841
|
T121;T131;T109
|
36,296,447
|
strategi improv bioavail bioactiv physic chemic behavior curcumin curcumin ccm one frequent explor plant compound various biolog action antibacteri antivir antifung antineoplast antioxidantanti inflammatori properti laboratori data clinic trial demonstr bioavail bioactiv curcumin influenc featur curcumin molecular complex type curcumin high capac form molecular complex protein whey protein bovin serum albumin lactoglobulin carbohydr lipid natur compound eg resveratrol piperin quercetin complex increas bioactiv bioavail curcumin current review provid derivat strategi curcumin term biolog physico chemic aspect strong focus differ type protein character method thermodynam featur protein curcumin complex aim evalu best perform current literatur review offer take consider various biolog effect ccm whole approach ccm biomolecul interact ccm protein ccm nanomateri ccm natur compound regard molecular strategi improv bioactiv well bioavail curcumin biolog system
|
D003474;D000970
|
T121;T130;T109
|
36,296,446
|
silico approach glycinin conglycinin chain soybean product okara use papain bromelain studi explor util sustain soybean product okara base silico approach silico approach well biopep databas peptiderank databas peptid calcul databas pepcalc toxinpr databas allertop databas employ evalu potenti glycinin conglycinin deriv peptid potenti sourc bioactiv peptid major protein precursor found protein okara soybean product furthermor primari structur biolog potenti physicochem sensori allergen characterist theoret releas antioxid peptid predict research glycinin subunit conglycinin select potenti precursor bioactiv peptid base silico analysi notabl among antioxid peptid first potenti protein precursor releas bioactiv peptid evalu determin frequenc occurr fragment given activ biopep databas analysi sever antioxid bioactiv peptid glycinin subunit conglycinin sequenc silico proteolysi use select enzym papain bromelain obtain antioxid peptid investig analyz use peptiderank pepcalc allergen analysi use allertop reveal silico proteolysi deriv antioxid peptid probabl nonallergen peptid also perform molecular dock mpo myeloperoxidas peptid overal present studi highlight glycinin subunit conglycinin could promis precursor bioactiv peptid antioxid peptid develop sever applic
|
D013025;D005916
|
T168;T116;T123
|
36,296,445
|
maillard hydrolyt reaction subcrit water extract bioactiv compound licoric nowaday subcrit water extract swe techniqu extens investig worldwid thermal reaction inevit occur subcrit water condit rare studi order investig behavior differ reaction swe bioactiv compound licoric maillard reaction process access via product hydrolyt reaction analyz accord kinet paramet addit content total phenol flavonoid extract obtain differ temperatur determin total antioxid capac evalu hplc abt result show flavonoid phenol licoric well new compound generat via maillard reaction contribut antioxid activ extract fluoresc color absorb extract show degre maillard reaction increas rise extract temperatur kinet extract glycyrrhiz acid show first extract diffus hydrolyz glycyrrhetin acid mono glucuronid glycyrrhetin acid follow first order mechan find could provid deep insight swe process new method produc glycyrrhetin acid mono glucuronid glycyrrhetin acid
|
D006035;D006034;D014315
|
T121;T002;T109
|
36,296,444
|
sustain isocyanid synthesi n substitut formamid use phosphorus oxychlorid presenc triethylamin solvent simpl green high effici protocol synthesi isocyanid describ reaction involv dehydr formamid phosphorus oxychlorid presenc triethylamin solvent c product isocyanid obtain high excel yield less min method offer sever advantag includ increas synthesi speed relat mild condit rapid access larg number function isocyanid excel puriti increas safeti minim reaction wast new approach synthesis dehydr isocyanid formamid signific environment friend prior method
|
D005559;D003486
|
T131;T197;T109
|
36,296,443
|
direct hydroxyl benzen hydrogen peroxid use fe complex encapsul mesopor type zeolit mesopor type zeolit myz prepar acid base treatment commerci type zeolit yz mesopor volum myz six time higher yz fe terpi complex encapsul myz yz differ fe content fe x l myz fe x l yz x amount fe prepar character oxid benzen h use fe x l myz fe x l yz catalyst carri phenol select produc fe contain zeolit catalyst result oxid activ benzen increas increas iron complex content fe x l myz fe x l yz catalyst oxid activ benzen use fe x l myz catalyst higher use fe x l yz furthermor ad mesopor increas catalyt activ iron complex iron complex content increas
|
D006861;D017641
|
T121;T197;T130
|
36,296,442
|
nardoguaianon l isol nardostachi jatamansi improv effect gemcitabin chemotherapi via regul age signal pathway sw cell pancreat cancer seventh lead caus cancer relat death worldwid known king cancer current gemcitabin gem clinic drug choic chemotherapi advanc pancreat cancer poor drug sensit ineffect chemotherapi nardoguaianon l g novel guaian type sesquiterpenoid isol nardostachi jatamansi dc exhibit anti tumor activ base newli discov g anti pancreat cancer activ laboratori paper aim evalu potenti valu combin g gem sw cell includ cell viabil cell apoptosi coloni assay tandem mass tag tmt marker base proteom technolog result show g combin gem signific inhibit cell viabil effect obvious singl drug addit use tmt marker base proteom technolog demonstr age rage signal pathway activ medic combin furthermor reactiv oxygen speci ros mitochondri membran potenti mmp assay use valid proteom result final apoptosi detect flow cytometri conclus g combin gem induc increas ros level decreas mmp sw cell age rage signal pathway ultim lead apoptosi g improv effect gem chemotherapi may use potenti combin therapi pancreat cancer
|
D032404;D010190
|
T191;T002
|
36,296,441
|
develop biotechnolog photosensit photodynam therapi cancer research treatment benchtop clinic practic photodynam therapi pdt noninvas therapeut approach appli studi treatment various diseas context pdt suggest new therapi adjuv therapi tradit cancer therapi mode action pdt consist generat singlet oxygen reactiv oxygen speci ros administr compound call photosensit ps light sourc molecular oxygen combin generat control photochem reaction photodynam mechan produc ros singlet oxygen induc apoptosi andor cell death induc necrosi degener tumor vasculatur stimul antitumor immun respons induct inflammatori reaction illumin region howev tradit compound use pdt limit applic context compound biotechnolog origin photosensit activ associ nanotechnolog use pdt aim applic sever type cancer less toxic toward neighbor tissu better absorpt light aggress type cancer review present studi involv innov develop ps aim improv effici pdt cancer treatment specif focus clinic translat applic ps natur origin cancer
|
D010778;D009369
|
T061;T191
|
36,296,440
|
use photodynam therapi treatment brain tumor review literatur treatment neoplast diseas brain still challeng modern medicin therefor advanc methodolog need ration success contribut earli diagnosi primari metastat tumor grow within brain photodynam therapi pdt seem valuabl method treatment precancer cancer lesion includ brain tumor main advantag pdt high effici minim invas serious side effect compar chemotherapi radiotherapi review conduct comprehens search articl scientif inform databas websit organ deal cancer treatment key point clinic trial conduct research also discuss common databas pubm googl scholar ebsco scopus elsevi use articl english languag reliabl credibl main analyz type public consid includ clinic preclin studi systemat review case report base collect materi see scientist alreadi demonstr potenti pdt applic field brain tumor therefor review treatment neoplasm central nervous system cns common tumor glioblastoma multiform gbm explor addit overview general principl pdt well mechan action therapi therapeut platform brain tumor describ research carri june
|
D010778;D001932;D005909
|
T061;T191
|
36,296,439
|
antileishmani anthracen endoperoxid efficaci vitro mechan structur activ relationship leishmaniasi vector born diseas caus protozo leishmania parasit previous studi shown endoperoxid ep select kill leishmania host cell therefor studi work set new anthracen deriv ep acep togeth non endoperoxid analog model system leishmania tarentola promastigot ltp j macrophag antileishmani activ select mechan effect compound explor studi reaction iron ii chemic system leishmania correl structur paramet activ demonstr compound set activ compound logp ow larger polar surfac area smaller effect compound ic ltp lt highest select si gt pyridyl tert butyl substitut acep interest also analog demonstr activ select mechanist studi shown ep activ iron chemic system ltp due ep group howev molecular structur beyond ep group signific contribut differenti mitochondri inhibit leishmania identifi compound pair good start point subsequ experi pathogen leishmania vitro anim model
|
D000981;D007891
|
T121;T204
|
36,296,438
|
cyclocitr emerg bioactiv compound plant cyclocitr cc main apocarotenoid caroten increas plant resist stress recent appear novel bioactiv composit varieti organ plant anim plant cc mark stress signal accru advers ecolog condit cc regul nuclear gene express sever signal pathway lead stress toler review attempt made summar recent find potenti role cc emphas cc biosynthesi signal involv regul abiot stress review clear discuss compound great potenti abiot stress toler use photosynthet rate enhanc conclus review establish signific refer base futur research
|
D019207;D004224
|
T121;T127;T109
|
36,296,437
|
essenti oil colombian plant antivir potenti dengu virus base chemic composit vitro silico analys current therapi prevent sever dengu diseas essenti oil eo serv primari sourc research discoveri phytomedicin altern therapi fourteen eo sampl obtain distil six plant use colombian folk medicin gcms analysi identifi terpen cytopath effect cpe reduct assay reveal differ antivir activ eo lippia alba citral chemotyp carvon rich fraction lippia origanoid phellandren chemotyp turnera diffusa exhibit strong antivir activ ic gml si eo piper aduncum ocimum basilicum l origanoid carvacrol thymol chemotyp exhibit weak antivir activ denv cpe reduct gml si gt cluster one way anova analys suggest strong antivir activ eo could attribut increas amount non phenol oxygen monoterpen sesquiterpen hydrocarbon dock analys autodock vina predict bind affin denv e protein terpen twenti sesquiterpen hydrocarbon kcalmol eight oxygen monoterpen kcalmol seven monoterpen hydrocarbon kcalmol studi report first time differ antivir activ eo denv correspond composit monoterpen sesquiterpen
|
D009822;D003716;D032411;D012717
|
T005;T002;T109
|
36,296,436
|
vitro bioaccess antioxid activ phenol compound coffe fortifi yogurt yogurt consid one popular healthi dairi product exploit deliveri matrix phenol compound studi coffe powder ad yogurt function ingredi produc coffe fortifi yogurt total phenol compound antioxid activ individu hydroxycinnam acid identifi quantifi mass spectrometri result coffe fortifi yogurt compar ferment coffe plain yogurt coffe fortifi yogurt higher total phenol content antioxid activ compar plain yogurt howev total phenol compound found coffe fortifi yogurt repres origin content coffe caffeoylquin acid abund phenol compound coffe ferment coffe coffe fortifi yogurt display lower amount individu phenol compound respect coffe recoveri respect protect effect yogurt matrix total individu coffe phenol compound observ vitro digest result higher bioaccess comparison digest ferment coffe moreov coffe fortifi yogurt show highest antioxid valu digest find clear demonstr coffe fortifi yogurt consid signific sourc bioaccess hydroxycinnam acid besid health benefit ferment dairi product
|
D000975;D015014
|
T123;T121;T168;T039;T044
|
36,296,435
|
design synthesi investig novel nitric oxid releas aromat aldehyd drug candid treatment sickl cell diseas sickl cell diseas scd caus singl point mutat ensu deoxygen induc polymer sickl hemoglobin hbs reduct bioavail vascular nitric oxid contribut pathogenesi diseas proof concept studi success incorpor nitrat ester group onto two previous studi potent antisickl aromat aldehyd td vzhe form td vzhe hybrid respect compound stabl buffer demonstr expect releas whole blood vitro mice promis vzhe retain function antisickl activ parent vzhe molecul moreov vzhe unlik vzhe signific attenu rbc adhes laminin suggest compound potenti vivo rbc anti adhes properti relev vaso occlus event crystallograph studi show vzhe vzhe also bind ligand hb make similar protein interact knowledg gain investig provid uniqu opportun generat superior candid drug scd enhanc benefit
|
D006451;D000755
|
T123;T047;T116
|
36,296,434
|
electrochem aptasensor base au nanoparticl decor porous carbon deriv metal organ framework ultrasensit detect chloramphenicol facil sensit electrochem aptam sensor aptasensor base au nanoparticl decor porous carbon aunpspc composit develop effici determin antibiot drug chloramphenicol cap aunp modifi metal organ framework aunpszif appli precursor synthes porous carbon homogen aunp distribut direct carbon step nitrogen atmospher synthes aunpspc exhibit high surfac area improv conduct moreov load aunp could enhanc attach aptam surfac electrod au bond ad cap poor conduct aptam cap complex form sensor surfac increas hindranc electron transfer result decreas electrochem signal base mechan develop cap aptasensor repres wide linear detect rang pm nm low detect limit pm sn addit propos aptasensor employ analysi cap honey sampl provid satisfactori recoveri
|
D000073396;D052157;D015374;D053768;D006108
|
T073;T075;T109;T196;T059;T114
|
36,296,433
|
integr hydrogeolog hydrochem isotop assess seawat intrus coastal aquif al qatif area eastern saudi arabia seawat intrus swi main threat fresh groundwat gw resourc coastal region worldwid earli identif delin threat help decis maker plan suitabl manag measur protect water resourc coastal communiti studi assess seawat intrus swi gw salin shallow deep coastal aquif al qatif area eastern region saudi arabia field hydrogeolog hydrochem investig coupl laboratori base hydrochem isotop analys h use integr studi hydrochem faci diagram ionic ratio diagram spatial distribut map gw physic chemic paramet ec tds cl br seawat fraction f sw generat depict later extent swi hydrochem faci diagram main use gw salin sourc identif result show shallow gw brackish salin type ec tds cl br concentr increas f sw trend seaward indic influenc swi shallow gw well locat close shorelin contrari deep gw show low f sw ec tds cl br indic less influenc swi gw chemistri moreov shallow gw enrich h isotop compar deep gw reveal mix recent water conclus reduct gw abstract central part studi area rais averag gw level three meter therefor protect deep gw swi salin pollut recommend implement manag practic entir region addit continu monitor deep gw recommend provid decis maker suffici data plan protect coastal freshwat resourc
|
D060587;D014874
|
T081;T131;T070;T082
|
36,296,431
|
toxicolog assess roast coffe silver skin testa coffea sp novel food ingredi roast coffe silver skin coffe product use current limit eg fertil energi product anim feed due low content fat carbohydr combin high content fiber polyphenol protein roast silver skin valuabl possibl food ingredi potenti applic includ partial flour replac bakeri product antioxid provid protein fiber sourc sport function food relev consumpt isol silver skin occur european union eu classifi novel food need premarket approv novel food applic must meet legal requir composit toxicolog inform review present inform silver skin composit toxicolog studi sever vitro studi subchron vivo studi avail negat result suggest need studi carcinogen effect reproduct chronic toxic avail studi far conclud toxic effect silver skin found expect novel food applic eu vitro studi mutagen potenti may need close formal data gap
|
D040503;D000074385
|
T168;T002
|
36,296,430
|
design synthesi biolog evalu lophan acid deriv antifung antibacteri agent order discov promis antifung antibacteri agent seri new deriv design synthes structur modif base natur occur antimicrobi compound lophan acid structur target compound well character spectroscop data stereochemistri compound determin x ray diffract analysi synthet compound evalu antimicrobi activ filament fungi rubrum mentagrophyt yeast c neoforman c albican gram posit gram negat bacteria mrsa mutan sobrinus e coli among found promis lead show potent inhibitori effect test fungal bacteri strain except e coli presenc c carboxyl ester group free hydroxi group c found essenti antifung antibacteri activ lophan acid deriv
|
D000935;D000890
|
T121;T195
|
36,296,428
|
vitro activ essenti oil distil colombian plant candida auri candida speci differ antifung suscept profil multi drug resist speci candida auri global health threat scenario highlight need search antifung altern essenti oil eo major compound could sourc new antifung molecul aim studi evalu vitro activ eo terpen c auri candida spp eleven eo evalu obtain hydro distil differ colombian plant terpen purchas eo chemic composit obtain gas chromatographymass spectrometri gcms antifung activ evalu follow clsi standard th edit cytotox test hacat cell line fungal growth kinet test time kill assay candida spp show differ suscept antifung activ eo terpen strain depend lippia origanoid thymol p cymen chemotyp eo thymol carvacrol limonen activ main drug resist strain activ eo terpen also slight cytotox hacat cell find studi suggest eo commerci terpen sourc develop new anti candida product aid identif new antifung target action mechan
|
D002175;D009822
|
T004;T109
|
36,296,427
|
chemic composit antifung anti biofilm activ volatil fraction convolvulus althaeoid l root tunisia antifung drug current avail most use treatment candidiasi exhibit phenomena toxic increas resist context plant materi might repres promis sourc antifung agent aim studi evalu first time chemic content volatil fraction vfs along antifung anti biofilm convolvulus althaeoid l root chemic composit determin gas chromatographi coupl flame ionize detector mass spectrometri total chemic compound detect n hexan vf chloroform vf fraction respect analysi reveal presenc four main compound n hexadeceno acid vinyl guaiacol bis ethylhexyl adip eicosan vf extract hexan vf n hexadeceno acid benzyl alcohol linol acid main compound found vf extract chloroform vf antifung minimum inhibitori concentr mic obtain fraction candida albican candida glabrata candida tropicali determin micro dilut techniqu valu candida spp rang mgml biofilm inhibitori concentr ibf sustain inhibit bsi assay c albican c glabrata c tropicali also investig vfs inhibit biofilm format mgml c albican mgml c glabrata mgml c tropicali obtain result highlight synergist mechan detect molecul prevent candidos biofilm format
|
D000935;D031254
|
T121;T195;T002
|
36,296,426
|
znoboron nitrid quantum dot nanocomposit enhanc photocatalyt degrad methylen blue methyl orang studi heterostructur photocatalyst zno nanoparticl decor boron nitrid quantum dot znobnqd success synthes simpl solut procedur synthes znobnqd show bnqds effect suppress recombin photoinduc electron hole transfer hole zno nanoparticl format heterojunct znobnqd nanocomposit thus demonstr superior photocatalyt perform excel stabil degrad methylen blue mb methyl orang mo uv light irradi base obtain result possibl photocatalyt mechan propos discuss thus znobnqd nanocomposit demonstr potenti effici low cost photocatalyst applic photodegrad organ dye wastewat environment remedi
|
D015034;D045663;D053761
|
T121;T197;T073
|
36,296,425
|
improv mucoadhes permeat vitro anticanc potenti synthes thiolat acacia karaya gum combin systemat studi thiolat polym one appropri approach impart higher mechan strength mucoadhes thiol modif gum karaya gum acacia carri esterif thioglycol acid ftir dsc xrd confirm complet thiolat reaction anticanc potenti develop thiomer studi cervic cancer cell line hela human cervic cell line hela inhibit concentr g l immobil thiol group found mmolg determin ellman method cytotox studi l fibroblast cell line indic thiomer biocompat bilay tablet prepar use ivabradin hydrochlorid model drug synthes thiolat gum mucoadhes polym tablet prepar use thiolat polym combin show swell mucoadhes resid time compar unmodifi gum thiol modif control releas drug h enhanc permeat drug fold porcin buccal mucosa compar tablet unmodifi gum thiolat polym show increas mucoadhes permeat anticanc potenti control releas thus util novel excipi formul develop
|
D007618;D000045
|
T121;T002;T109
|
36,296,424
|
assembl biolog function structur nucleic acid templat implement strategi overcom inhibit templat excess deliveri therapeut molecul pathogen cell often hamper unintend toxic normal cell principl problem circumv therapeut effector molecul split two inact compon assembl within target cell situ process realiz exploit target specif molecul templat direct proxim enhanc assembl modifi nucleic acid carri inert precursor fragment design co hybrid target specif templat nucleic acid enforc proxim acceler assembl function molecul antibodi recognit demonstr vitro feasibl adapt nucleic acid templat synthesi nat use oligonucleotid bear modifi peptid haplom templat assembl mimotop recogn therapeut antibodi trastuzumab enforc proxim promot mimotop assembl via traceless nativ chemic ligat nevertheless titrat particip haplom templat excess potenti limit trimolecular nat order overcom problem devis strategi haplom hybrid occur presenc target without subject titrat effect generaliz nat modif may find futur applic enabl direct target patholog cell
|
D009696
|
T123;T114
|
36,296,423
|
heavi metal depur step gracilaria chilensi outdoor cultur system seawe aquacultur affect natur anthropogen stressor put biomass product cultur risk seawe biomass commerci purpos princip pharmaceut andor nutraceut applic need free pollut therefor control cultur relev regul qualiti biomass aim work demonstr success util control outdoor cultur remov excess heavi metal accumul gracilaria chilensi import commerci seawe farm model specif design simpl oper heavi metal depur protocol util seawat tap water remov permit concentr reduct heavi metal includ cu cd zn biomass day cultur percentag depur heavi metal rang day maintain throughout day cultur cultur period monitor physicochem paramet temperatur salin dissolv oxygen among other remain stabl increas daili growth rate dgr biomass record day cultur consequ experiment setup success heavi metal depur highlight import control outdoor cultur import tool sustain
|
D044724;D019216;D000461;D012624;D004785;D014874
|
T131;T196;T204;T002
|
36,296,422
|
supplement sdf pig oocyt vitro matur improv subsequ embryo develop qualiti vitro matur oocyt inferior vivo matur oocyt translat low development capac embryo deriv vitro matur oocyt development potenti vitro matur oocyt usual impair due oxid stress stromal cell deriv factor l sdf reduc oxid stress inhibit apoptosi aim studi investig effect sdf supplement pig oocyt vitro matur ivm subsequ embryo develop explor act mechan sdf pig oocyt found ivm medium contain ngml sdf improv matur rate pig oocyt well cleavag rate blastocyst rate embryo generat somat cell nuclear transfer vitro fertil parthenogenesi supplement ngml sdf ivm decreas ros level increas mitochondri membran potenti alter express apoptosi relat gene pig oocyt porcin oocyt transcriptom data show sdf addit ivm alter express gene enrich purin metabol tnf signal pathway sdf supplement pig oocyt ivm also upregul mrna protein level yy tet two critic factor oocyt develop conclus supplement sdf pig oocyt ivm reduc oxid stress chang express gene involv regul apoptosi oocyt growth enhanc abil vitro matur pig oocyt support subsequ embryo develop find provid theoret basi new method improv development potenti pig vitro matur oocyt
|
D059471;D047108
|
T061;T039;T038;T042
|
36,296,421
|
advanc hybrid composit photocatalyt applic review heterogen photocatalyst garner extens attent sustain way environment remedi energi storag process water split solar energi convers pollut degrad exampl nowaday applic semiconductor base photocatalyst repres potenti disrupt technolog exploit solar radiat photocatalysi could generat strong impact decreas energi demand simultan mitig impact anthropogen pollut howev actual photocatalyst work energi radiat near uv region lt nm studi develop new photocatalyst high effici visibl rang spectrum requir regard hybrid organicinorgan photocatalyst emerg high potenti materi drastic improv visibl photocatalyt effici review analyz state art develop hybrid photocatalyst energi storag energi convers process well applic pollut degrad water treatment
|
D012993;D004785
|
T131;T070
|
36,296,420
|
grape pomac polyphenol sourc compound manag oxid stress inflamm possibl altern non steroid anti inflammatori drug flavonoid stilben lignan phenol acid class polyphenol found grape pomac gp investig import altern sourc activ substanc could use manag oxid stress inflamm benef antioxid anti inflammatori action gp present literatur deriv larg varieti experiment vitro vivo set vitro work decreas reactiv oxygen speci malondialdehyd thiobarbitur acid reactiv substanc level increas glutathion level show antioxid effect inhibit nuclear factor kappa b prostaglandin e inflammatori pathway decreas inflammatori marker interleukin il demonstr anti inflammatori action gp polyphenol vivo studi confirm antioxid increas catalas superoxid dismutas glutathion peroxidas level stimul endotheli nitric oxid synthas eno gene express anti inflammatori inhibit il il il interferon tnf c reactiv protein releas activ grape pomac whole extract also differ individu polyphenol contain gp modul endogen pathway respons reduc oxid stress chronic inflamm present review analyz effect gp oxid stress inflamm suggest could becom valuabl therapeut candid capabl reduc aforement patholog process grape pomac extract could becom adjuv treatment attempt reduc side effect classic anti inflammatori medic like non steroid anti inflammatori drug nsaid
|
D027843;D013267;D017705
|
T129;T116;T109;T168;T002
|
36,296,418
|
process optim amino acid composit antioxid activ protein polypeptid extract wast beer yeast repurpos wast beer yeast wbi main product brew industri attract consider attent recent year studi protein polypeptid extract ultrason assist extract enzymat hydrolysi process optim result maximum yield respect protein polypeptid wbi compos amino acid aa includ seven essenti amino acid eaa typic rich glutam acid glu glycin gli aa score aa reveal threonin thr saa methionin cystein limit aa wbi protein polypeptid furthermor antioxid activ wbi polypeptid lower kda hydroxyl radic dpph radic abt radic respect signific higher wbi protein kda therefor protein polypeptid extract wbi sourc high qualiti aa appli food feed industri due small molecular weight abund aa great antioxid activ wbi polypeptid promis use function addit pharmaceut healthcar industri
|
D000975;D000596
|
T123;T121;T116;T039;T044
|
36,296,416
|
elucid bind featur dissoci pathway inhibitor modul sar cov main proteas multipl molecular dynam simul covid caus differ neurolog symptom peopl includ smell inabl tast dizzi confus delirium seizur stroke etc owe issu vaccin effect updat coverag still need one diversifi strategi backstop manag ill character structur basi ligand recognit main proteas pro sar cov facilit ration design develop potenti drug candid high affin select covid date coval non coval inhibitor alloster modul report bind differ activ site pro present work appli molecular dynam md simul systemat character potenti bind featur catalyt activ site alloster bind site pro use dataset structur pro inhibitor complex result consist current studi addit umbrella sampl us simul use explor dissoci process substrat pathway alloster pathway inform provid new insight protein featur pro facilit ration drug design covid
|
D056004;D000086382
|
T066;T067;T044;T047
|
36,296,415
|
lc ms transcriptom analysi lipopeptid biosynthesi bacillus velezensi cmt respond dissolv oxygen dissolv oxygen key factor lipopeptid ferment better understand link oxygen suppli lipopeptid product bacillus velezensi cmt mechan synthesi antimicrobi lipopeptid bacillus velezensi cmt examin product surfactin iturin cmt detect liquid chromatographi mass spectromet lc ms differ condit transcriptom analysi perform rpm lipopeptid product mgl mgl respect signific chang yield iturin surfactin increas transcriptom analysi reveal enrich differenti gene concentr go term oxid reduct process mark enrich lipopeptid synthesi pathway includ microbi metabol divers environ carbon metabol two compon system observ import express level four surfactin synthetas gene increas higher howev iturin synthetas gene express furthermor modular surfactin synthetas overexpress fold rpm rpm suggest effici surfactin assembl result surfactin overproduct studi provid theoret basi construct engin strain high lipopeptid product adapt differ
|
D055666;D000890
|
T123;T121;T116
|
36,296,414
|
prefac nitric oxid modul health diseas nitric oxid small free radic molecul biosynthes nitric oxid synthas nos famili oxidoreductas respons convers natur substrat l arginin l citrullin
|
D009569;D002956
|
T121;T197;T116;T123
|
36,296,412
|
biosourc poli lactic acid polyamid blend effect elastom morpholog mechan properti fulli biobas polylactid pla polyamid pa blend prepar melt mix elastom intermedi phase address low elast brittl pla blend incorpor biobas elastom made poli butylen adip co terephthal pbat polyethylen oxid peo copolym found chang rigid interfac pla pa much elasticdeform one well promot interfaci compat interfaci tension polym pair spread coeffici reveal high tendenc peo spread plapa interfac result complet wet regim interfaci tension mnm fulli percol rubberi phase peo layer plapa interfac enhanc interfaci interact pla chain mobil contribut better distribut stress around dispers phase lead shear yield matrix result also show morpholog modif improv compat upon peo addit wt contribut improv elong break impact strength ternari plapapeo blend obtain super tough multiphas system
|
D020724;D009757
|
T122;T073;T109
|
36,296,411
|
prepar evalu f alf nota noc pet imag neuroendocrin tumor comparison ga ga dotanota noc somatostatin receptor overexpress neuroendocrin neoplasm repres favor target molecular imag studi investig potenti f alf nota nal octreotid compar vivo dota nota nal octreotid radiolabel gallium
|
D005710;D018358
|
T196;T191
|
36,296,410
|
comparison main metabolit differ matur stage camellia vietnamensi huang seed camellia vietnamensi huang import woodi oil crop china attract much attent abund nutrit compon pharmaceut valu seed undergo complex seri physiolog biochem chang matur consequ alter metabolit order investig endogen metabol c vietnamensi hainan island seed develop studi ultra high perform liquid tandem chromatographi coupl quadrupol time flight mass spectrometri uhplcq tof ms multivari statist analysi msa use analyz differ chemic compound c vietnamensi seed among four matur stage total metabolit identifi methanol extract seed c vietnamensi five metabolit belong benzen substitut deriv deoxyribonucleosid linear diarylpropanoid found three comparison group consist regul trend kyoto encyclopedia gene genom kegg result show phloretin methylthioadenosin differenti express metabolit seed growth period indol l tryptophan differenti express metabolit seed growth period addit flavonoid metabolit detect differenti express indic flavonoid dynam chang oil tea camellia seed develop stage find provid data better understand endogen metabol pathway c vietnamensi seed develop
|
D000432;D028244
|
T131;T130;T002;T109
|
36,296,409
|
itraconazol induc increas gilteritinib exposur mediat cypa oatpb gilteritinib fda approv tyrosin kinas inhibitor approv treatment relapsedrefractori flt mutat acut myeloid leukemia primarili elimin via cypa mediat metabol pathway sensit co administr known cypa inhibitor itraconazol howev precis mechan itraconazol cypa modul drug affect absorpt disposit gilteritinib remain unclear present investig demonstr pretreat itraconazol associ signific increas system exposur gilteritinib mice recapitul observ clinic drug drug interact howev plasma level gilteritinib modest increas cypa defici mice influenc itraconazol ensu vitro vivo studi reveal gilteritinib transport substrat oatpb type transport gilteritinib exposur increas mice oatpb defici abil itraconazol inhibit oatpb type transport vivo conting metabol cypa isoform find provid new insight pharmacokinet properti gilteritinib molecular mechan under drug drug interact itraconazol
|
D017964;D015470
|
T121;T191;T109
|
36,296,407
|
bioactiv guid fraction identif antidiabet compound syzygium polyanthum wight leaf extract streptozotocin induc diabet rat model background earlier studi hypoglycem activ polyanthum wight leaf methanol extract identifi squalen major chemic compound present studi conduct assess hypoglycem effect fraction subfract methanol extract polyanthum compar squalen use bioassay guid vivo studi method methanol extract fraction use liquid liquid fraction method streptozotocin induc type diabet rat use studi hypoglycem effect result find show chloroform fraction signific p lt lower blood glucos level diabet rat compar control fraction chloroform fraction yield subfract wherebi subfract exhibit higher blood glucos lower effect lipid profil test show total cholesterol level subfract squalen treat group decreas signific p lt immunohistochemistri studi reveal none treatment regener pancreat cell gas chromatographi mass spectrophotomet analysi identifi presenc squalen activ methanol extract chloroform fraction subfract silico analysi reveal higher affin squalen protein receptor control lipid metabol metformin conclus data obtain present work suggest crude methanol extract exert highest hypoglycem effect compar fraction subfract squalen confirm synergist effect may respons hypoglycem activ polyanthum
|
D027842;D003921;D008687
|
T121;T050;T002;T109
|
36,296,406
|
util nutrit polyphenol compound underutil plant seed health applic plant repres signific part human diet human util everi part plant surviv seed except seed offer high protein unsatur fat fibr essenti vitamin miner various food applic also promis reservoir bioactiv compound various phytochem polyphenol compound capabl maintain improv well present abund quantiti plant malvacea cannabacea famili known fibr rich stem benefit humankind serv numer purpos mani centuri exploit extens various commerci industri use seed often regard product fibr process scientif discov essenti role combat hypercholesterolemia diabet cancer oxid stress maxim use agricultur wast promis approach creat sustain world accord concept sustain develop goal sdgs
|
D012639;D064209
|
T123;T002;T109
|
36,296,405
|
general method synthesi carbon encapsul fe composit applic water treatment paper simpl environment friend method develop prepar high stabl c fe composit control morpholog use sodium algin carbon sourc easili obtain fe precursor morpholog prepar c fe composit inherit correspond precursor fe surviv anneal treatment character field emiss scan electron microscopi fesem transmiss electron microscopi tem x ray diffract xrd induct coupl plasma atom emiss spectroscopi icp ae c fe composit resist oxid acidif aggreg exhibit porous structur ferromagnet properti room temperatur moreov adsorpt perform c fe composit evalu absorb mb methylen blue liquid environ experi indic c fe composit exhibit high enhanc adsorpt capac effici compar correspond precursor fe general method synthesi c fe composit provid promis applic high effici remov mb industri effluent
|
D008751;D018508
|
T121;T109;T052;T130;T057
|
36,296,404
|
chemic properti peanut oil arachi hypogaea l tainan oxid volatil format arachi hypogaea l tainan purpl skin characterist studi investig effect differ materi shell unshel peanut temperatur c properti extract peanut oil result show antioxid compon total flavonoid tocopherol tocopherol oxid stabil main affect roast temperatur p lt fifti eight volatil compound identifi peanut oil oxid divid three main group roast process use princip compon analysi volatil format chang differ materi temperatur assess agglom hierarch cluster analysi result provid use refer inform peanut oil applic food industri
|
D000975;D010367
|
T123;T121;T044;T039;T002
|
36,296,403
|
experiment comput analysi newli synthes benzotriazinon sulfonamid alpha glucosidas inhibitor diabet mellitus chronic metabol disord pancrea secret insulin bodi cell recogn result carbohydr metabol caus hyperglycemia may fatal various organ diseas increas day day preval among peopl age includ young adult children acarbos miglitol famous alpha glucosidas inhibitor complic patient problem flatul pain bloat diarrhea loss appetit overcom challeng crucial discov new anti diabet drug minim side effect purpos benzotriazinon sulfonamid synthes structur character ft ir h nmr c nmr spectroscopi vitro alpha glucosidas inhibit studi synthes hybrid conduct use spectrophotometr method synthes compound reveal moder good inhibit activ particular nitro deriv e f found effect inhibitor enzym ic valu silico studi includ molecular dock well dft analysi also strengthen experiment find lead compound e f show strong hydrogen bond interact within enzym caviti dft studi also reinforc strong bind interact deriv biolog molecul due lowest chemic hard valu lowest orbit energi gap valu
|
D003920;D061385
|
T121;T047
|
36,296,402
|
enantioselect decarboxyl cycloaddit azomethin ylide chromon carboxyl acid herein describ synthesi varieti chiral hybrid pyrrolidin chromanon polycycl deriv conveni annul azomethin ylide chromon carboxyl acid realiz brnsted base catalysi produc high function product high yield good stereoselect asymmetr intermolecular decarboxyl cyclize
|
D002264;D002867
|
T109
|
36,296,401
|
chemotaxonom marker leaf bud common finnish tree shrub rapid uhplc ms fingerprint tool speci identif studi chemotaxonom tool creat basi ultra high perform liquid chromatographi mass spectrometri uhplc ms identif common finnish decidu tree shrub leaf bud metabolit bud extract screen uhplc esi qqq ms uhplc esi q orbitrap ms discov suitabl marker speci two approach test marker select uniqu speci specif marker obtain select fingerprint per speci major marker maximis sensit fingerprint marker use creat two select ion record base fingerprint tool uhplc esi qqq ms method evalu select repeat robust plant speci identif analys leaf bud sever replic speci creat chemotaxonom tool shown provid uniqu chromatograph profil studi speci less min varieti plant metabolit flavonoid triterpenoid hydroxycinnam acid deriv found serv good chemotaxonom marker studi speci case speci specif marker superior creat select repeat fingerprint
|
D014197;D014315
|
T002;T109
|
36,296,400
|
wet end chemic properti new kind fire resist paper pulp base ultralong hydroxyapatit nanowir new type fire resist paper base ultralong hydroxyapatit hap nanowir report author research group superior properti promis applic various field high temperatur resist fire retard heat insul electr insul energi environment protect biomedicin wet end chemic properti fire resist paper pulp import papermak mechan perform paper play guid role practic product fire resist paper paper wet end chemic properti new kind fire resist paper pulp base ultralong hap nanowir studi first time focus wet end chemic paramet effect paramet properti floccul retent drain white water circul fire resist paper pulp effect properti prepar fire resist paper experiment result indic wet end chemic properti new kind fire resist paper pulp base ultralong hap nanowir uniqu entir differ tradit paper pulp base plant fiber wet end chemic properti fire resist paper pulp signific influenc inorgan adhes content affect runnabl paper machin properti prepar fire resist paper floccul properti fire resist paper pulp base ultralong hap nanowir affect conduct zeta potenti addit inorgan adhes fire resist paper pulp base ultralong hap nanowir could signific increas conduct fire resist paper pulp reduc particl size paper pulp floccul increas tensil strength fire resist paper addit fire resist paper pulp base ultralong hap nanowir presenc inorgan adhes exhibit excel antibacteri perform work contribut acceler commerci process applic new type fire resist paper base ultralong hap nanowir
|
D017886;D053770
|
T121;T122;T073;T197
|
36,296,399
|
recoveri polyphenol use pressur hot water extract phwe black rosehip follow encapsul increas bioaccess antioxid activ work pressur hot water extract phwe hydrophil polyphenol black rosehip fruit maxim use respons surfac methodolog simultan optim term extract yield total antioxid capac total poli phenol catechin total monomer anthocyanin cyanidin glucosid extract paramet includ temperatur x c solvent solid ratio x mlg investig independ variabl experiment obtain valu fit second order polynomi model optim condit determin use multipl regress analysi analysi varianc black rosehip extract bre obtain optim phwe condit encapsul biopolym coat liposom spray dri enhanc process digest stabil reconstitut fabric particl averag size nm zeta potenti mv moreov encapsul provid remark protect phenol vitro gastrointestin digest condit result fold phenol bioaccess fraction also fold higher antioxid activ compar nonencapsul bre conclus phwe combin biopolym coat potent method product stabl safe edibl natur extract deliveri poli phenol compound food dietari supplement
|
D027826;D002392
|
T121;T002;T109
|
36,296,398
|
hesperetin abil diminish mono polymicrobi biofilm toxic hesperetin aglycon citrus flavonoid hesperidin due limit inform regard hesperetin antimicrobi potenti emerg need novel antimicrobi studi antimicrobi activ microdilut assay antibiofilm activ differ assay two model mono polymicrobi biofilm toxic mtt brine shrimp lethal assay hesperetin inhibit growth candida isol minim inhibitori concentr mic mgml inhibitori potenti toward staphylococcus aureus lower mic mgml hesperetin mgml reduc abil candida form biofilm moder reduc exopolysaccharid level biofilm matrix effect erad h old c albican biofilm promis mgml inhibit staphylococc biofilm format requir higher concentr hesperetin lt inhibit mic mgml establish polymicrobi c albican aureus biofilm signific inhibit lowest examin hesperetin concentr mgml crystal violet cfu assay hesperetin toxic examin toward mrc fibroblast ic mgml brine shrimp lethal assay lc gt mgml hesperetin effici combat growth biofilm format candida speci howev antibacteri applic examin due cytotox effect provok antibacteri concentr
|
D006569;D000890
|
T121;T127;T109
|
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