PMID
int64 35.7M
36.4M
| Title/Abstract
stringlengths 22
8.78k
| MeshTerms
stringlengths 7
101
| SemanticTypes
stringlengths 4
64
|
|---|---|---|---|
36,296,619
|
differ volatil compound femal male bud trichosanth anguina l base hs spme gc ms multivari statist analysi trichosanth anguina l famili cucurbitacea monoeci diclin plant consum veget anti inflammatori antioxid effect chemic composit content volatil compound femal male bud anguina explor headspac solid phase microextract gas chromatographi mass spectrometri hs spme gc ms technolog combin multivari statist analysi result show content volatil compound differ femal male bud trimethyl vinyltetrahydro h pyran ol trimethyl vinyldihydro h pyran h one main volatil compound femal male bud base multivari statist analysi orthogon project latent structur discrimin analysi opl da test content seven compound signific differ femal male bud content three compound male bud higher femal ie e dimethyl nonatrien tetramethyl cycloundecatrien e caryophyllen convers content z hexen ol z hexenyl benzoat z hexenyl salicyl hexen ol femal bud higher male bud first report differ volatil compound femal male bud anguina enrich basic research monoeci diclin plant provid refer studi plant sex differenti
|
D029778;D055549
|
T002;T109
|
36,296,618
|
potenti essenti oil base anticholinesteras insecticid anophel vector review insect nervous system critic function integr cholinerg system acetylcholinesteras ach key enzym essenti anophel consist major malaria vector speci nervous system furthermor nervous system also primari target site insecticid use malaria vector control program insecticid incorpor insecticid treat net use indoor residu spray core intervent employ malaria vector control howev anophel resist insecticid grown rapid due major setback novel agent potenti activ resist anophel andor capac overcom resist current approv insecticid urgent need essenti oil potenti natur sourc novel insecticid potenti inhibit anophel ach target current review scientif evid highlight abil essenti oil specif essenti oil constitu serv anticholinesteras insecticid reason publish data scientif databas essenti oil essenti oil constitu anticholinesteras ovicid larvicid pupicid adulticid activ analyz identif major constitu activ essenti oil possibl influenc biolog activ also critic evalu furthermor toxic mammal well potenti activ mammalian ach target also review import identifi novel potent insecticid essenti oil discuss relat human safeti cost effect final critic insight review use inform futur research toward potent safe anticholinesteras insecticid manag anophel malaria vector
|
D000852;D007306;D009822;D008288
|
T131;T047;T204;T109
|
36,296,616
|
cytotox properti c polyacetylen fresh root panax ginseng human epitheli ovarian cancer cell although c polyacetylen panax ginseng exhibit cytotox properti various tumor cell experi epitheli ovarian carcinoma cell studi aim investig cytotox effect c polyacetylen p ginseng ovarian cancer cell line four unreport fifteen known c polyacetylen obtain root p ginseng use repeat chromatographi open column mplc prepar hplc chemic structur compound determin analyz spectroscop data nmr ir optic rotat hr ms structur new polyacetylen elucid r r heptadeca epoxi diyn diyl diacet r r heptadeca en epoxi diyn diyl diacet haptadeca epoxi methoxi diyn diol r r r acetoxi dihydroxyheptadeca en diyn name ginsenoyn p q acetyl panaxytriol respect subsequ vitro experi skov human epitheli ovarian carcinoma cell perform assess cytotox properti isol among isol panaquinquecol exhibit remark cytotox effect human ovarian cancer cell ic valu skov ic valu therefor c polyacetylen deriv p ginseng may warrant investig therapeut potenti epitheli ovarian cancer
|
D005894;D010051
|
T191;T002
|
36,296,615
|
metabolom wild like dendrobium officinal differ origin region differ dendrobium officinal tradit chines medicin consider commerci valu pharmacolog activ environment factor differ origin great influenc dendrobium officinal metabolit affect pharmacolog activ studi sought identifi differenti metabolit wild imit cultiv officinal stem differ origin use wide target metabolom approach metabolit detect character includ flavonoid lipid amino acid deriv alkaloid found although chemic constitut officinal cultur three habitat parallel content signific differ meanwhil kegg pathway enrich analysi reveal distinct metabolit among three group main involv flavon flavonol biosynthesi explor differ content flavonoid hplc perform four main flavonoid content use one refer distinguish officinal differ grow origin conclus comprehens profil metabol differ officinal grown differ origin provid contribut scientif basi research qualiti evalu officinal
|
D031667;D000470;D047309
|
T123;T121;T109;T131;T002
|
36,296,614
|
investig polycycl aromat hydrocarbon element profil smoke fish fish vulner environment pollut polycycl aromat hydrocarbon heavi metal one common appli process method smoke differ speci appli global henc studi aim investig smoke process polycycl aromat hydrocarbon element accumul five differ speci rainbow trout atlant bonito hors mackerel sea bass atlant bluefin tuna common process trade smoke fish industri process yield water hold capac ph also investig result reveal proxim differ among fish speci influenc water hold capac process yield ph import process sustain qualiti end product main find proxim composit impact accumul pah heavi metal differ level test sampl maximum permiss limit heavi metal especi toxic element found accept limit hors mackerel determin speci vulner pah heavi metal accumul
|
D011084;D019216;D004785;D017686;D014874
|
T131;T196;T013;T109
|
36,296,613
|
biowast deriv high effici reusabl carbon nanospher speedi remov organ dye aqueous solut current work explor adsorpt effici carbon nanospher cnss deriv oil palm leav opl sourc biowast cnss synthes c obtain c demonstr maximum remov effici malachit green mg physicochem microscop characterist analys fesem tem ftir raman tga xps studi presenc surfac oxygen site poros cnss synergist influenc speed remov mg brilliant green bg congo red cr dye minim adsorb dosag mg minimum contact time min differ ph condit adsorpt effici cost effect near bg mg cr respect maximum adsorpt capac opl base cnss bg mgg mg mgg cr adsorpt isotherm freundlich langmuir temkin kinet model pseudo first order pseudo second order elovich adsorpt process three dye cnss explor detail bg cr adsorpt freundlich isotherm best mg show best fit temkin model adsorpt kinet three dye follow pseudo second order model reusabl studi conduct evalu effect cnss remov mg dye show effici even sever cycl high effici cnss surfac oxygen group speedi remov organ dye within min cnss highlight paper
|
D054118;D014874
|
T131;T073
|
36,296,612
|
tripeptid leu ser trp regul vascular endotheli cell phenotyp switch mediat vascular smooth muscl cell deriv small extracellular vesicl packag mir tripeptid lsw initi identifi potent ace inhibitori peptid soybean protein recent report exert protect effect angiotensin ii induc endotheli dysfunct via extracellular vesicl ev howev molecular mechan especi lipid accumul induc atherosclerosi still remain unclear studi aim investig whether protect effect lsw endotheli dysfunct vascular endotheli cell vec via vascular smooth muscl cell vsmcs deriv mirna packag ev mirna concentr ev lsw treat vsmcs lev intern hvuec target program cell death protein pdcd express huvec oxid low densiti lipoprotein oxldl appli induc endotheli dysfunct huvec oxldl induc endotheli dysfunct huvec attenu pdcd knockout lev incub result studi suggest novel function lsw regul function ev vascular cell oxldl induc atherosclerot model
|
D000067128;D050197;D035683
|
T026;T123;T114;T047;T046
|
36,296,611
|
ultrasound acet acid peracet acid altern sanit chlorin compound fresh cut kale decontamin chlorin compound usual appli veget sanit concern applic thus studi aim evalu ultrasound khz acet acid mgl peracet acid mgl combin altern treatment mgl sodium dichloroisocyanur overal microbi physicochem nutrit qualiti kale store c assess impact salmonella enterica typhimurium verifi plate count scan electron microscopi ultrasound combin peracet acid exhibit higher reduct aerob mesophil mold yeast coliform c log cfug respect microbi count remain stabl storag highest reduct salmonella occur combin ultrasound acet acid mgl acet acid mgl log cfug respect synergist effect observ combin treatment cellular morpholog pathogen alter combin ultrasound acet acid mgl peracet acid chang titrat total acid mass loss vitamin c total phenol compound occur altern treatment present equal greater efficaci chlorin compound could potenti use decontamin kale
|
D001937;D004202;D017606
|
T168;T197;T131;T002;T167
|
36,296,610
|
photon photographi first diagnost approach polaroid emuls transfer paper paolo gioli artwork aim research studi diagnos first time polaroid emuls transfer contemporari artist paolo gioli artwork provid preliminari knowledg materi artwork appropri protocol appli futur studi spectral analysi perform follow multi technic approach first mock sampl creat follow gioli techniqu one origin artwork gioli compos for fiber optic reflect raman ftir fourier transform infrar spectroscopi techniqu chosen accord complet non invas requir sampl collect obtain spectra ftir suffici assign dye found transfer polaroid emuls howev provid signific inform cellulos base materi diagnost result obtain for determin dye develop present mock sampl obtain polacolor type paolo gioli origin artwork creat polacolor type
|
D010781;D004396
|
T130;T197;T109;T057
|
36,296,609
|
metabolom analysi phytochem compound agricultur residu eggplant solanum melongena l eggplant fruit rich natur product produc worldwid howev cultiv generat larg amount scarc use agricultur residu poor chemic character studi aim identifi quantifi metabolom determin composit select phytochem overal antioxid capac various anatom part plant plant root leaf stem fruit analyz quantit mass spectrometri base untarget metabolom chemoinformat phytochem quantifi spectrophotometr analysi moreov determin total antioxid capac distinct plant part infer possibl biolog effect plant metabolit various secondari metabolit identifi terpen phenol compound alkaloid saponin distribut throughout plant leaf fruit present highest concentr phenol compound flavonoid anthocyanin alkaloid accompani highest antioxid capac although stem root show lowest abund secondari metabolit provid around compound compar leaf fruit overal studi improv understand eggplant metabolom conclud plant rich secondari metabolit antioxid properti show potenti nutraceut biopharmaceut applic
|
D032323;D012503
|
T168;T002;T109
|
36,296,608
|
preliminari microbiolog test carvon geraniol select deriv compound may form process isomer oxid work present literatur review biolog activ carvon geraniol deriv compound form process isomer process geraniol isomer oxid product compound also obtain moreov work present preliminari microbiolog test cream addit biolog activ compound carvon geraniol carvacrol carvon isomer product nerol geraniol isomer product linalool geraniol isomer product citral geraniol oxid product post reaction mixtur obtain carvon isomer relat simpl composit also ad cream test without isol pure compound may cheaper altern cream prepar addit pure compound mixtur obtain geraniol isomer process complex composit therefor compound lowest molecular weight easili commerci avail select studi content test compound cream rang wet follow microorgan select microbiolog test gram negat bacterium escherichia coli k gram posit bacterium staphylococcus epidermidi fungi candida albican trichophyton rubrum aspergillus niger penicillium chrysogenum content carvacrol nerol geraniol citral inhibit growth e coli attenu growth c albican rubrum hand carvacrol citral poor attenu growth mould fungi p chrysogenum niger
|
D039821;D013729
|
T123;T109
|
36,296,607
|
qualit analysi relat palynolog character biolog evalu propoli prespa nation park greec propoli sampl geograph part northwest greec prespa nation park pnp character plant endem center biodivers hotspot character pollen analysi chemic analyz biolog evalu major studi propoli show typic chemic constitu phenol acid flavonoid chalcon european type sampl mediterranean type propoli rich diterpen also identifi palynolog character implement determin botan origin explain chemic composit total phenol content dpph assay show european type propoli sampl possess strong antioxid activ inhibit gml moreov promis antibacteri activ extract mic valu mgml moder antifung activ mic valu mgml notic sampl highest activ signific content terpen mediterranean type propoli sampl pnp area repres rich sourc antibacteri antioxid compound confirm fact propoli signific natur product potenti use improv human health stimul bodi defens final noteworthi signific chemic divers demonstr even sampl limit geograph area pnp
|
D011429;D047188;D004224
|
T123;T121;T109
|
36,296,606
|
psidium guajava l incalcul underexplor food crop phytochemistri ethnopharmacolog industri applic psidium guajava l guava small tree known fruit flavor cultiv almost around globe tropic area fruit amaz rich antioxid vitamin c potassium dietari fiber differ part world plant hold special place respect fruit nutrit item pharmacolog research shown plant potenti fruit sourc also benefici effect varieti chronic diseas due rich nutrit phytochem profil primari goal document provid updat overview psidium guajava l bioactiv secondari metabolit well avail studi focus health benefit potenti industri applic sever studi conduct psidium guajava l relat use pharmaceut industri howev clinic efficaci applic still debat therefor review detail studi respect phytochemistri plant modern instrument gc lc ms discuss biolog activ secondari metabolit isol plant extens discuss order perform long term clinic trial learn effect drug applic various health benefit structur activ relationship establish base literatur conclud plant wide varieti biopharmaceut applic whole articl call long term clinic trial obtain greater understand use treat differ diseas
|
D031647
|
T168;T002
|
36,296,605
|
high throughput metabolom integr network pharmacolog reveal under mechan paeonia radix alba treat rheumatoid arthriti mechan action potenti target paeonia radix alba baishao b treatment adjuv induc arthriti aia rat explain use metabolom network pharmacolog techniqu research evid develop anti rheumatoid arthriti ra drug enrich
|
D029596;D002392;D001172;D001169;D004365
|
T121;T123;T050;T109;T047;T002
|
36,296,604
|
effect microwav plasma pre treatment cotton cellulos dissolut util cellulos full potenti constrain recalcitr dissolut result rigid polymer chain high crystallin high molecular weight extens intra intermolecular hydrogen bond network therefor pretreat cellulos usual consid step help facilit dissolut investig use microwav oxygen plasma pre treatment strategi enhanc dissolut cotton fiber aqueous naohurea solut consid greener solvent system compar other attenu total reflect fourier transform infrar spectroscopi scan electron microscopi powder x ray diffract analys reveal plasma pretreat cotton cellulos lead physicochem chang cotton fiber pretreat cotton cellulos oxygen plasma min result reduct molecular weight cellulos crystallin respect reduct molecular weight crystallin led increas dissolut w v cotton cellulos naohurea solvent system thus treat cotton cellulos microwav oxygen plasma alter physicochem properti enhanc dissolut
|
D002482;D008872
|
T123;T070;T109;T122;T057
|
36,296,602
|
hydrophob effect current understand hydrophob interact involv believ fundament drive forc mani chemic biolog phenomena aqueous environ review focus current understand hydrophob effect solut embed water interfac appear solut water main affect structur interfaci water topmost water layer solutewat interfac recent structur studi water air water interfac hydrat free energi deriv util investig origin hydrophob interact found hydrat free energi depend size solut increas solut size reason divid initi hydrophob solvat process various dissolv behavior solut expect differ solvat process dispers accumul distribut solut regard origin hydrophob effect ascrib structur competit hydrogen bond interfaci bulk water appli understand characterist hydrophob interact depend hydrophob interact solut size concentr direct natur hydrophob interact temperatur effect hydrophob interact
|
D014867;D006859
|
T121;T197;T196
|
36,296,601
|
ddx upregul hydrogen peroxid induc melanogenesi sk mel human melanoma cell ddx dead box rna helicas divers biolog function multicellular pathway object studi investig role ddx regul melanogenesi explor signal pathway involv various concentr hydrogen peroxid use induc melanogenesi sk mel human melanoma cell melanin content assay tyrosinas activ analysi western blot analysi perform determin ddx involv melanogenesi transient transfect perform overexpress silenc ddx gene immunoprecipit perform use antityrosinas antibodi base result cell viabil test melanin content activ tyrosinas key melanogenesi enzym sk mel human melanoma cell hydrogen peroxid mm chosen induc melanogenesi treatment h notabl increas promot activ ddx treatment hydroperoxid h melanin content tyrosinas activ peak ddx transfect cell overexpress ddx increas melanin content tyrosinas express oxid stress induc h ddx co immunoprecipit tyrosinas melanogenesi enzym interact ddx tyrosinas strong increas oxid stress ddx could increas melanogenesi h treat condit thus target ddx could novel strategi develop molecular therapi skin diseas
|
D008545;D008546
|
T191;T050
|
36,296,600
|
jnc novel podophyllotoxin deriv exert anticanc drug radiosensit effect colorect cancer cell object studi determin whether benzyloxi dimethoxi phenyl dihydro h furo naphtho dioxol one jnc novel chemic deriv apopicropodophyllin act novel potenti anticanc reagent radiosensit colorect cancer crc cell first use mtt assay assess whether jnc could inhibit cell prolifer hct dld cell ic valu cell line calcul nm respect h treatment use dose approxim ic valu test whether jnc radiosensit effect crc cell line clonogen assay reveal dose enhanc ratio der hct dld cell respect cell count assay show combin jnc ioniz radiat ir enhanc cell death treatment jnc ir alon induc cell death wherea combin jnc ir increas cell death annexin v propidium iodid assay show combin jnc ir increas apoptosi compar induc jnc ir alon dcfda mitosox base assay reveal mitochondri ros product enhanc combin jnc ir final found suppress ros n acetylcystein nac block apoptot cell death induc combin jnc ir xenograft model also indic combin jnc ir increas apoptot cell death tumor mass result collect suggest jnc act radiosensit exert anticanc effect crc cell promot apoptosi mediat mitochondri ros
|
D011838;D000970;D015179
|
T121;T039;T191;T109
|
36,296,599
|
valoris potenti invas acacia dealbata longifolia melanoxylon land clear acacia spp invas southern europ high propag rate produc excess biomass exacerb wildfir risk howev lignocellulos biomass acacia spp may utilis divers biorefineri applic studi attenu total reflect fourier transform infrar spectroscopi ftir atr high perform anion exchang chromatographi puls amperometr detect hpaec pad lignin content determin use compar composit characteris dealbata longifolia melanoxylon addit biomass treat three white rot fungi speci ganoderma lucidum pleurotus ostreatus tramet versicolor preferenti degrad lignin result show pre treatment signific alter neutral sugar composit reduc lignin content sugar releas enzymat saccharif enhanc case possibl due synergi white rot fungi mild alkali pretreat exampl dealbata stem treat alkali p ostreatus saccharif yield nmol mg higher sampl treat alkali nmol mg fold higher non pretreat control nmol mg characteris biomass pretreat generat data creat valu unus biomass resourc contribut implement sustain biorefin system due cours generat valu lead econom incent landown cut back invas acacia spp frequent thus reduc excess biomass exacerb wildfir risk
|
D008031;D000045
|
T123;T002;T109
|
36,296,597
|
prepar physicochem character gelatin aldehyd deriv present studi aim prepar novel free radic scaveng water solubl compound deriv gelatin specif gelatin syringaldehyd gelatin anisaldehyd gelatin vanillin synthes thorough studi physicochem properti particular compound character uv vis spectroscopi fourier transform infrar spectroscopi scan electron microscopi notabl demonstr thermogravimetri differenti scan calorimetri three deriv exhibit higher thermal stabil gelatin free radic scaveng activ examin compound explor standard spectrophotometr abt assay ii assay oxid degrad hyaluron acid monitor rotat viscometri found gelatin gelatin syringaldehyd demonstr highest efficaci scaveng oh radic wherea gelatin anisaldehyd least effect efficaci scaveng alkyloxi alkylperoxi type free radic via hydrogen atom transfer properti follow order gelatin gt gelatin vanillin gt gelatin syringaldehyd gt gelatin anisaldehyd electron donor properti determin use abt assay reveal follow order one electron reduct abt gelatin gt gelatin anisaldehyd gt gelatin vanillin gt gelatin syringaldehyd
|
D005780;D006820
|
T121;T123;T116;T109;T122
|
36,296,596
|
assess binari agaros carbopol buccal gel mucoadhes drug deliveri ex vivo vivo character agaros ag natur occur biocompat marin seawe extract convert hydrocolloid gel hot water notabl gel strength current mucoadhes properti fulli explor therefor main aim studi evalu mucoadhes potenti ag binari dispers combin carbopol p cp mucoadhes gel prepar gel fabric via homogen evalu ex vivo mucoadhes swell index si dissolut stabil studi mucoadhes properti ag concentr depend improv addit cp maximum mucoadhes strength ms g mucoadhes flow time ft min mucoadhes time volunt mt min si h observ formul f mucoadhes time investig volunt mt influenc ag concentr greater correspond ft valu formul contain w v ag f f abl sustain releas drug till h optim formul f evok inflamm irrit pain buccal caviti healthi volunt also stabl month therefor ag could consid natur potenti polym profound mucoadhes properti deliv drug mucos rout
|
D009061;D011108
|
T104;T023;T122
|
36,296,595
|
synthesi character curcumin load nanoparticl poli glycerol sebac novel high stabl anticanc system research altern administr method anticanc drug toward enhanc effect select repres major challeng scientif communiti last decad polymer nanostructur deliveri system repres promis altern convent drug administr sinc ensur secur transport select target provid activ compound protect elimin minim drug toxic non target cell present research poli glycerol sebac biocompat polym synthes nanostructur allow curcumin encapsul natur occur polyphenol phytochem isol powder rhizom curcuma longa l curcumin select anticanc agent virtu strong chemotherapeut activ differ cancer type combin good cytocompat within healthi cell despit strong fascin biolog activ possibl exploit novel chemotherapeut hamper low water solubl result poor absorpt low bioavail upon oral administr henc encapsul within nanoparticl may overcom issu nanoparticl obtain nanoprecipit easi scalabl techniqu character term size stabil time use dynam light scatter transmiss electron microscopi confirm nanos dimens spheric shape final biolog investig demonstr enhanc cytotox effect curcumin load pgs nps human cervic cancer cell compar free curcumin
|
D003474;D053758;D000970
|
T121;T130;T073;T109
|
36,296,592
|
comparison chromat spectrophotometr properti white red wine produc galicia northwest spain appli pca wine complex matrix compos numer substanc color import influenc qualiti consum accept color affect numer factor pre ferment ferment oper age contact addit certain substanc studi differ chromat paramet determin wine red white made galician northwest spain grape varieti paramet obtain use simpl rapid inexpens spectrophotometr methodolog color intens hue total polyphenol content total polyphenol index tpi folin ciocalteu index fci total anthocyan total tannin color coordin measur cielab system influenc age barrel red wine use chip white red wine paramet also studi princip compon analysi pca carri character wine accord chromat characterist applic pca experiment data result satisfactori classif studi white red wine accord cite enolog practic
|
D014920;D027843
|
T129;T168;T116;T002
|
36,296,591
|
impact purifi blueberri extract vitro probiot mucin adhes effect probioticintestin pathogen system sever argument made substanti need natur antimicrobi food industri blueberri extract compel healthi connot possibl obtain multipurpos solut antioxid color antimicrobi antimicrobi perspect blueberryanthocyanin rich extract associ capac inhibit harm bacteria caus littl inhibit potenti probiot microorgan studi potenti benefit come synergi extract probiot may particular interest therefor present work aim evalu effect anthocyanin rich extract adhes five differ probiot well effect probiot capac compet block pathogen adhes mucinbsa treat surfac result show despit loss probiot adhes combin presenc extract probiot effect reduc overal amount adher viabl pathogen cell probiot alon regardless probioticpathogen system consid furthermor instanc combin extract bifidobacterium animali bo allow almost complet inhibit pathogen adhes
|
D029798;D019936
|
T168;T007;T002
|
36,296,590
|
domino aza michael n ar heteroaromat rout c substitut alkyl h indol carboxyl ester new synthesi c substitut alkyl h indol carboxyl ester report seri methyl arylacryl aza michael acceptor prepar aromat substitut activ toward n ar reaction subsequ reaction seri primari amin generat titl compound initi sequenc expect produc indolin product oxid heteroaromat interven generat indol reaction proceed anhydr condit dmf c use equimolar quantiti acryl amin equiv k co give indol product reaction involv aza michael addit follow n ar ring closur heteroaromat sinc reaction run nitrogen final oxid indol like result reaction dissolv oxygen dmf substrat incorpor arylacrylonitril prove reactiv prepar use protocol synthesi reaction substrat relat reactiv mechanist detail convers discuss
|
D007211;D004952
|
T109
|
36,296,589
|
inhibitori effect myriocin non enzymat glycat bovin serum albumin advanc glycat end product age compound produc non enzymat glycat protein involv diabet relat complic investig potenti anti glycat activ myriocin myr fungal metabolit cordycep effect myr format age result glycat bovin serum albumin bsa interact myr bsa studi multipl spectroscop techniqu comput simul found myr inhibit format age end stage glycat reaction exhibit strong anti fibril activ spectroscop analysi reveal myr quench fluoresc bsa static process possibl format complex approxim molar ratio bind bsa myr main depend van der waal interact hydrophob interact hydrogen bond synchron fluoresc uv visibl uv vis spectra result indic conform bsa alter presenc myr fluoresc probe displac experi molecular dock suggest myr primarili bound bind site subdomain iia bsa find demonstr myr potenti anti glycat agent provid theoret basi function research myr prevent treatment age relat diseas
|
D012710;D017127
|
T123;T130;T116;T109
|
36,296,588
|
applic crisprca system pathogen detect review earli rapid diagnosi pathogen import prevent control epidem diseas polymeras chain reaction pcr techniqu requir expens instrument control special test site complex solut treatment step profession oper limit applic practic pathogen detect method base cluster regular interspac short palindrom repeat crispr crispr associ protein crisprca system character strong specif high sensit conveni detect suitabl practic applic articl first review crisprca system introduc applic two type system repres type ii cas type v casa casb casa type vi casa pathogen detect final challeng prospect propos
|
D064113;D064130
|
T123;T040;T116
|
36,296,587
|
impact differ pretreat process freez ultrasound high pressur sensori function properti black garlic allium sativum l black garlic bg emerg deriv fresh garlic enhanc nutrit properti studi aim develop function bg product good consum accept end bg treat freez f bg ultrasound u bg hhp h bg assess sensori function properti result show f bg h bg higher allyl cystein sac polyphenol flavonoid content bg h bg f bg display best sensori qualiti day age hydroxymethylfurfur hmf sac polyphenol identifi influenti sensori paramet moreov f bg h bg group achiev optim tast day oppos untreat bg need day therefor propos approach signific reduc process time enhanc physic sensori function properti bg conclus freez hhp techniqu may consid promis pretreat develop bg product good function sensori properti
|
D005737;D001688
|
T168;T121;T123
|
36,296,586
|
thermomechan properti carbon nanocomposit pegda photopolym work uv curabl resin poli ethylen glycol diacryl pegda reinforc three differ type nanofil pristin graphen g multiwal carbon nanotub mwnts hybrid mwnts graphen mass ratio hyb pegda mix homogen nanofil oligom shear mix photopolymer afford thin stabl film thermomechan properti afford nanocomposit indic superior reinforc abil pristin graphen compar mwnts intermedi behavior hybrid
|
D037742;D006108;D053761
|
T104;T196;T073;T109
|
36,296,585
|
discoveri bis hydroxybenzyl acetylcyclohexanon novel ftsz inhibitor multi drug resist increas pathogen bacterium pneumonia main respons mening communiti acquir pneumonia cap highlight need new anti pneumococc agent identifi potenti anti pneumococc agent enol act hinder cell divis process perturb z ring dynam insid cell enol also shown inhibit ftsz polymer induc aggreg vitro affect activ tubulin alkalin phosphatas dock studi show bind near loop catalyt site ftsz similar effect z ring ftsz assembl observ b subtili indic could broad spectrum anti bacteri agent use target gram posit bacteria conclus compound show strong anti pneumococc activ prompt pre clinic studi explor potenti
|
D003598;D001426
|
T123;T116
|
36,296,584
|
tannin deriv hard carbon stabl lithium ion anod graphit anod well establish commerci use lithium ion batteri system howev limit capac graphit limit develop lithium ion batteri hard carbon obtain biomass high promis anod materi advantag enrich microcrystallin structur characterist better lithium storag tannin secondari product metabol plant growth rich sourc earth mechan hard carbon obtain deriv lithium ion batteri littl studi paper success appli hard carbon obtain tannin anod illustr relationship structur lithium storag perform meanwhil enhanc perform graphen oxid skill compound contact electrolyt charg transfer capabl effect enhanc capac pvp hc mah g cycl current densiti g capac retent rate present work lay foundat open idea applic biomass deriv hard carbon lithium anod
|
D008094;D006108
|
T121;T196;T109
|
36,296,582
|
lanostan triterpenoid ergostan steroid ganoderma luteomarginatum cytotox macrofungus ganoderma luteomarginatum one main speci ganoderma fungi distribut hainan provinc china fruit bodi wide use folk healthi food prevent tumor explor potenti cytotox constitu g luteomarginatum phytochem investig ethyl acet solubl fraction ethanol extract fruit bodi fungus led isol twenti six lanostan triterpenoid includ three undescrib one togeth eight ergostan steroid structur three new lanostan triterpenoid elucid lanosta dien acetyloxi diol lanosta dien oxo diol methoxi lanosta dien trioxo diol oic acid methyl ester analysi nmr hresim spectroscop data isol assay cytotox activ use three human cancer cell line k bel sgc seven lanostan triterpenoid one ergostan steroid show definit cytotox ic valu rang gml among cytotox lanostan triterpenoid compound show general cytotox three human cancer cell line compound exhibit signific select cytotox k cell ic valu gml respect furthermor preliminari structur cytotox relationship propos
|
D014315;D032902;D000970
|
T121;T004;T109
|
36,296,581
|
sex differ cardiolipin tissu distribut base target lipidom analysi uhplc qtof msms cardiolipin cls involv atp product mitochondria biogenesi apoptosi mitophagi tissu distribut provid insight function mitochondria relat diseas howev report tissu distribut cls remain limit research cls identifi heart liver kidney spleen lung skelet muscl brain use ultra high perform liquid chromatographi coupl quadrupol time flight mass spectrometri uhplc qtof msms distribut sex differ cls seven tissu compar target lipidom approach total cls identifi cls found heart liver kidney spleen lung skelet muscl brain respect compar distribut cls heart liver kidney skelet muscl cls spleen lung brain show signific differ moreov result indic sex differ cls liver kidney total cls liver tissu cls kidney tissu signific sex differ screen find target lipidom analysi demonstr tissu distribut cls essenti dynam state sex differ cls might provid evid mitochondri relat mechan physiolog patholog condit
|
D053719;D002308
|
T063;T109
|
36,296,580
|
capillari electrophoresi method base molecular imprint solid phase extract select sensit detect histamin food studi sensit capillari electrophoresi ce method base molecular imprint solid phase extract misp propos determin histamin food molecular imprint polym mip synthes bulk polymer use misp adsorb select extract histamin optim condit misp ce method possess good linear histamin detect concentr rang gl limit detect limit quantif method calcul gl gl respect histamin spike rice vinegar liquor sampl detect develop method recoveri histamin content fish prawn pork chicken breast soy sauc sampl determin use develop method high perform liquid chromatographi method signific differ found two method
|
D054802
|
T063
|
36,296,579
|
enhanc visibl light driven photocatalyt activ fe dope graphit c n fe dope graphit carbon nitrid fe cn photocatalyst various fe ion content prepar via ultrason method detail physic character indic fe ion success dope frame g c n photocatalyt activ investig methyl orang mo tetracyclin hydrochlorid tc use target pollut prepar fe cn materi exhibit higher photocatalyt activ pure g c n specif degrad rate fe cn visibl light time higher mo time higher tc g c n increas photocatalyt activ fe cn main attribut enhanc light absorpt abil rapid separ photogener carrier moreov import activ speci reaction process also explor result indic main activ speci
|
D013752;D004785
|
T131;T195;T109
|
36,296,578
|
tool allevi drug resist mycobacterium tuberculosi mycobacterium tuberculosi mtb acid fast bacillus caus tuberculosi tb pathogen caus million death per estim anoth million peopl suffer latent tb either asymptomat diagnos frequenc drug resist increas due intrins link factor host bacterium instanc poor access tb diagnosi reduc treatment era covid pandem result tb death reduct newli diagnos case tb addit detect mtb isol exhibit resist multipl drug mdr xdr tdr complic scenario pathogen favour moreov convent method detect drug resist may miss mutat make challeng decid treatment regimen howev owe collabor initi last two decad wit sever advanc detect method drug discoveri drug resist isol major belong nucleic acid detect techniqu review highlight summar molecular mechan under drug resist mtb recent advanc resist detect method newer drug use drug resist tb
|
D009169;D000086382;D014376;D009696
|
T123;T007;T067;T114;T047
|
36,296,577
|
squaramid catalyz asymmetr mannich reaction dicarbonyl compound pyrazolinon ketimin pathway enantioenrich pyrazolyl isoxazolyl aminopyrazolon deriv seri n boc ketimin deriv pyrazolin one use electrophil enantioselect mannich reaction differ dicarbonyl compound method provid direct pathway access amino pyrazolon deriv bear quaternari substitut stereocent contain two privileg structur motif diketon pyrazolinon substructur adduct obtain excel yield enantioselect er employ low load mol quinin deriv bifunct squaramid organocatalyst wide rang substrat addit util obtain product demonstr one step transform enantioenrich diheterocycl system pyrazolyl pyrazolon isoxazolyl pyrazolon potenti promis candid drug discoveri
|
D011803;D047069
|
T121;T109
|
36,296,576
|
fatti acid tocopherol composit pomac seed oil five grape varieti southern spain grape pomac seed import winemak product oil rich bioactiv compound fatti acid tocopherol character oil product five spanish grape varieti palomino fino pedro ximnez muscat alexandria tempranillo tintilla de rota high content ufa found analyz sampl grape pomac oil general oleic acid pufa content seed oil lower pufa content also mark higher linolen acid pufa content improv pufa pufa ratio oil studi show good indic nutrit qualiti low valu atherogen pomac seed thrombogen indic pomac seed high valu relationship hypo hypercholesterolem fatti acid pomac seed three tocopherol determin tocopherol pomac oil higher relat content tocopherol wherea seed oil higher relat content tocopherol signific higher content total tocopherol found pomac oil higher oil red varieti pomac mgkg product oil pomac contain stem mgkg product oil obtain consid sourc vitamin e consumpt benefici health
|
D024505;D027843
|
T129;T121;T116;T127;T109;T168;T002
|
36,296,575
|
switch n cap region l amino acid vegf mimet helic peptid n cap region helix short n termin amino acid stretch contribut nucleat stabil helic structur vegf mimet helic peptid qk n cap region previous demonstr key factor qk helic fold paper explor effect chiral invers n cap sequenc qk fold perform conform analysi solut circular dichroism nmr spectroscopi effect modif qk stabil serum prolif effect also evalu
|
D000596;D042461
|
T123;T121;T116
|
36,296,574
|
nipecot acid deriv potent agent neurodegener preliminari studi alzheim diseas ad common neurodegen disord character memori loss cognit impair patholog fulli clarifi therefor high effect treatment obtain yet almost current treatment option aim allevi symptom elimin diseas acetylcholinesteras inhibitor main therapeut agent ad wherea oxid stress inflamm found great signific develop progress neurodegener work ethyl nipecot ethyl piperidin carboxyl heterocycl carboxyl acid deriv act gaba reuptak inhibitor use research diseas involv gabaerg neurotransmiss dysfunct amid various carboxyl acid bear antioxid andor anti inflammatori properti eg ferul acid sinap acid butyl hydroxycinnam acid compound signific antioxid potenc lipid peroxid inhibitor ic low oxid protein glycat inhibitor inhibit act dpph reduc agent moreov compound moder lox inhibitor could reduc rat paw edema induc carrageenan final possess inhibitori activ acetylcholinesteras ic low result indic compound could potenti optim multi target agent direct ad
|
D003373;D000544
|
T123;T047;T048;T109
|
36,296,573
|
recent advanc polym flood china polym flood draw lot attent technic matur reservoir first commerci polym flood china perform daqe oilfield one largest applic world laboratori test daqe research china show viscoelast high molecular weight polym play signific role increas displac effici henc encourag convent field applic new find viscoelast effect polym residu oil satur ros high concentr high molecular weight hchmw polym flood field test conduct although field test well document subsequ progress seldom report recent report hchmw limit applic daqe agre observ laboratori core flood earli field test howev caus discrep unclear thus systemat summari polym flood mechan field test china necessari paper explain hchmw wide use consid new understand polym flood mechan differ opinion viscoelast effect polym ros reduct critic review mechan polym flood wettabl chang graviti stabil effect discuss regard wide report laboratori test explain term viscoelast effect polym ros recent find chines field test also summar salt resist polym srps good econom perform use produc water prepar polym solut econom environment promis notabl progress srp flood new amphiphil polym field test china summar lesson learn given format blockag repres high inject pressur produc product abil report sever oil field due misunderstand polym inject although influenc viscoelast polym reservoir condit unknown inject viscous polym displac medium high viscos oil recommend especi import old well could caus damag paper clarifi mislead notion polym flood implement base theori practic china
|
D011108;D010578
|
T104;T122;T109
|
36,296,572
|
ir catalyz chemo regio enantioselect allyl enol dimethyl trimethylsilyl oxi cyclohex en one involv keto enol isomer util dimethyl trimethylsilyl oxi cyclohex en one made unsymmetr dimethylcyclohexan dion iridium catalyz allyl enol involv keto enol isomer accomplish mild condit chemoselect regioselect enantioselect facilit quaternari carbon adjust reaction condit method provid substitut en yl hydroxi dimethylcyclohex en one good high yield high level chemo regio enantioselect chiral carbon fluorin bond format induc adjac chiral carbon center allyl hydroxi dimethylcyclohex en one well
|
D007495;D005461
|
T123;T196
|
36,296,571
|
effect storag condit content molecul malus domestica chopin cv vitro antioxid activ appl fruit one wide cultiv temper fruit rich sourc bioactiv compound sinc grow number consum increas seek safe healthi food product organ appl product provid possibl studi content bioactiv compound organ appl depend temperatur storag time determin chopin appl store day c c analys perform use hplc method control sampl fresh appl contain highest content vitamin c mg g fw l ascorb mg g fw dha mg g fw total carotenoid mg g fw caroten mg g fw lutein mg g fw sampl store c highest content total carotenoid lutein sampl store c contain caroten zeaxanthin appl store c contain signific chlorophyl g g fw sampl store c contain total polyphenol sampl store day character highest content total flavonoid sampl store day character highest content epigallocatechin quercetin rutinosid highest content quercetin kaempferol found control sampl highest content total flavonoid found appl store c
|
D027845
|
T168;T002
|
36,296,570
|
synthesi anticanc activ thiadiazol methoxyphenyl substitu base result previous work design synthes thiadiazol deriv cytotox activ obtain compound determin biolog studi use mcf mda mb breast cancer cell normal cell line fibroblast result show compound display weak anticanc activ toward two breast cancer line estrogen depend cell line mcf estrogen independ cell line mda mb compound activ toward mcf breast cancer cell sct decreas dna biosynthesi mechan anticanc action thiadiazol also investig choos set investig protein attract anticanc target silico studi demonstr possibl multitarget mode action synthes compound like mechan action new compound connect activ caspas
|
D013830;D000970;D001943
|
T121;T191;T109
|
36,296,568
|
mechan kinet thermodynam decomposit high energi deriv triazolo b tetrazin paper present data research studi mechan kinet thermodynam decomposit three high energi compound triazolo b tetrazin diamin ttda amino hydrazino triazolo b tetrazin ttga dinitroamino triazolo b tetrazin dntt point chang reaction mechan thermal effect differ intens establish valu activ induct energi limit stage decomposit obtain format nanostructur carbon nitrid c n condens decomposit product cyanogen c n hydrogen cyanid hcn gaseous product shown concentr energi diagram reaction product compil paramet heat resist thermal safeti prove c c ttda c c ttga c c dntt energi thermodynam properti also estim work found activ energi decomposit process kjmol ttda kjmol ttga kjmol dntt averag induct energi catalyt process ecat ttga establish kjmol dntt kjmol induct energi inhibit process e ttda estim kjmol
|
D006856;D006571
|
T131;T197;T109
|
36,296,567
|
paradigmat approach find valenc base k banhatti redefin zagreb entropi niobium oxid metal organ framework entropi thermodynam function chemistri reflect random disord molecul particular system process base number altern configur access distanc base entropi use solv varieti difficulti biolog chemic graph theori organ inorgan chemistri field articl character crystal structur niobium oxid metal organ framework investig also use inform function comput entropi build structur degre base indic includ k banhatti indic first redefin zagreb index second redefin zagreb index third redefin zagreb index atom bond sum connect index
|
D009556;D000073396
|
T196;T109
|
36,296,566
|
develop microemuls electrokinet capillari chromatographi method analysi dispers dye extract polyest fiber studi aim develop method separ dispers dye extract polyest fiber nine commerci avail dispers dye use dye three polyest fabric test extract dye cm long thread carri chlorobenzen c h separ perform use microemuls electrokinet capillari chromatographi meekc photodiod array detect microemuls base borat buffer organ phase n octan butanol mixtur surfact sodium dodecyl sulphat sodium cholat use addit isopropanol cyclodextrin microemuls result notabl improv resolut select content addit optim use doehlert experiment design valu coeffici varianc obtain valid process illustr repeat intermedi precis migrat time fit rang respect develop method also success appli differenti real sampl polyest thread collect cloth obtain result confirm propos method may use discrimin analysi polyest die dispers dye promis employ forens practic
|
D020374;D003505
|
T130;T059;T109
|
36,296,565
|
resveratrol analogu select estrogen signal pathway modul structur activ relationship resveratrol plant deriv phytoalexin found grape red wine mani plant use asian folk medicin extens studi pleiotrop biolog activ crucial anticanc chemoprevent properti resveratrol also report antioxid phytoestrogen phytoestrogen activ resveratrol assay differ vitro vivo model although work brought first look conflict result common accept resveratrol interact estrogen receptor function mix agonistantagonist wide accept hydroxyl group crucial resveratrol cytotox antioxid activ respons bind estrogen receptor work assay resveratrol analogu seven bar methoxi group six hydroxyl analogu differ combin posit purpos recombin estrogen receptor estrogen depend mcf ishikawa cell use studi support silico dock studi shown resveratrol tetrahydroxystilben pentahydroxystilben hexahydroxystilben may act select estrogen receptor modul
|
D011960;D013267
|
T109;T116;T192
|
36,296,564
|
effect current avail nanoparticl synthesi rout biocompat fibroblast cell line nanotechnolog acquir signific dental applic safeti regard human health still question due chemic util various synthesi procedur titanium nanoparticl produc three novel rout includ bacillus subtili amp nbsp cassia fistula hydrotherm heat character shape phase state size surfac rough element composit textur morpholog sem tem xrd afm drs dls ftir novel titanium nanoparticl test cytotox mtt assay l mous fibroblast cell use test cytotox prepar titanium nanoparticl cell suspens dmem cell seed well plate incub titanium nanoparticl use mgml concentr control water titanium nanoparticl stock solut prepar microlit mtt dye pour well incub c h read record day day day day day result conclud titanium nanoparticl produc bacillus subtili remain non cytotox cell viabil gt titanium nanoparticl produc cassia fistula reveal mild cytotox day day day cell viabil moder cytotox found day day cell viabil titanium nanoparticl produc hydrotherm heat depict mild cytotox day day moder cytotox day sever cytotox day day cell viabil less p lt current studi conclud novel titanium nanoparticl prepar bacillus subtili safest sustain biocompat futur restor nano dentistri purpos
|
D014025;D053758
|
T196;T073
|
36,296,563
|
applic deep learn algorithm driven intellig raman spectroscopi methodolog qualiti control manufactur process guanxin tablet coupl convolut neural network cnn intellig raman spectroscopi methodolog rapid quantit analysi four pharmacodynam substanc solubl solid manufactur process guanxin tablet establish raman spectra real sampl collect portabl raman spectromet content danshensu ferul acid rosmarin acid salvianol acid b determin high perform liquid chromatographi diod array detect hplc dad content solubl solid determin use oven dri method establish cnn calibr model spectral characterist band screen competit adapt reweight sampl car algorithm perform cnn model evalu root mean squar error calibr rmsec root mean squar error cross valid rmsecv root mean squar error predict rmsep coeffici determin calibr rc coeffici determin cross valid rcv coeffici determin valid rp rp valu solubl solid salvianol acid b danshensu ferul acid rosmarin acid respect establish model use analysi three batch unknown sampl manufactur process guanxin tablet result show raman spectroscopi faster conveni convent method help implement process analysi technolog pat manufactur process guanxin tablet
|
D013059;D000077321
|
T070;T059;T066
|
36,296,562
|
anticoagul new old applic heparin recent decad heparin import anticoagul drug wide use clinic set prevent treat thrombosi varieti diseas howev depth research therapeut potenti heparin explor beyond anticoagul date heparin deriv test protect repair inflammatori antitumor cardiovascular diseas also explor antiangiogen prevent antivir agent atherosclerosi review focus new old applic heparin discuss potenti mechan explain biolog divers heparin
|
D013927;D002318
|
T047;T046
|
36,296,561
|
composit nanofib novel sorbent line line solid phase extract chromatograph system comparison detect free biogen monoamin metabolit plasma two differ pretreat approach use enrich separ biogen monoamin metabolit plasma high perform liquid chromatographi hplc determin first approach base line pack fiber solid phase extract pfspe coupl hplc allow simultan detect epinephrin e norepinephrin ne dopamin da methoxyl epinephrin mn norepinephrin nmn methoxytyramin mt hydroxytryptamin ht use develop line pfspe hplc method limit detect lod seven analyt rang ngml nmn mn ngml ne e da mt ht report rang ngml ne da ngml e ngml nmn mn mt ht line pfspe hplc employ second approach could provid simultan detect ne e da nmn mn linear verifi rang ngml ne e da ngml nmn mn lod five analyt rang ngml ne e da ngml nmn mn studi verifi possibl use nanofib adsorb line pfspe hplc system determin biogen monoamin metabolit human plasma compar line pfspe approach line pfspe method deserv attent main due greener charact deriv autom process high throughput less oper handl
|
D004298;D057139
|
T123;T121;T073;T109
|
36,296,560
|
coinag metal catalyz asymmetr reaction ortho alkynylaryl heteroaryl aldehyd keton coinag metal becom metal choic due excel catalyt activ organ transform process combin various chiral ligand coinag metal becam product area research access heterocycl deriv accord effici sustain manner review devot various recent develop coinag metal catalyz domino process ortho alkynylaryl heteroaryl aldehyd keton lead function heterocycl various gold chiral complex present method prepar chromen along indol cover ag chiral complex also prone interest activ cyclize follow reduct function enoliz keton diazomethyl phosphon asymmetr cu catalyz domino cyclize asymmetr transfer hydrogen reaction effici led function chromen remark exampl involv copper associ ruthenium context cyclize asymmetr hydrogen process also present
|
D012428;D063065
|
T131;T196;T109
|
36,296,559
|
metal coordin effect photophys dipyrrinato photosensit within work review metal coordin effect photophys metal dipyrrinato complex dipyrrinato complex promis candid search altern transit metal photosensit applic photodynam therapi pdt complex activ irradi light specif wavelength cytotox reactiv oxygen speci ros generat metal coordin allow use heavi atom effect enhanc triplet generat necessari generat ros addit flexibl complex metal ion substitut ligand allow possibl tune photophys properti general overview mechan photodynam therapi properti triplet photosensit given follow detail dipyrrinato complex describ literatur show relev photosensit pdt particular photophys properti ru ii rh iii ir iii zn ii pd ii pt ii ni ii cu ii ga iii iii al iii dipyrrinato complex discuss potenti futur develop field dipyrrinato metal complex address sever new research topic suggest throughout work propos signific advanc could made heterolept bis dipyrrinato zinc ii homolept bis dipyrrinato palladium ii complex applic photosensit pdt
|
D056831;D010778
|
T061;T104
|
36,296,558
|
anti adipogen effect salicortin twig weep willow salix pseudolasiogyn l cell salix pseudolasiogyn salicacea weep willow use tradit korean medicin treat pain fever due high concentr salicyl acid salicin present studi investig bioactiv compound pseudolasiogyn twig discov bioactiv natur product phytochem investig ethanol etoh extract pseudolasiogyn twig follow liquid chromatographi mass spectrometri lcms base analysi led isol two salicin deriv salicortinol salicortin structur determin interpret nmr spectra data lcms analysi best knowledg first report salicortinol isol pseudolasiogyn isol compound evalu anti adipogen effect l cell salicortinol salicortin found signific inhibit adipocyt differenti l cell particular salicortin exhibit strong inhibitori effect lipid accumul furthermor salicortin inhibit express lipogen adipogen transcript factor includ fasn fabp cebp cebp ppar without induc cytotox result suggest salicortin could potenti therapeut compound prevent treatment metabol disord obes
|
D032108
|
T002
|
36,296,557
|
high dispers vanadia anchor proton g c n effici select catalyst hydroxyl benzen phenol direct hydroxyl benzen green econom effici altern exist cumen process phenol product howev undesir phenol select high benzen convers hinder wide applic develop one pot synthesi proton g c n support vanadia catalyst v pg c n effici select hydroxyl benzen character suggest proton g c n dilut hcl boost generat amino group nhnh without chang bulk structur content surfac amino group determin dispers vanadia easili regul amount hcl ad prepar increas content surfac amino group benefit dispers vanadia eventu lead improv h activ benzen hydroxyl optim catalyst v pg c n achiev benzen convers phenol select c h oxid
|
D019800;D001554
|
T121;T131;T109
|
36,296,556
|
util agro industri residu rear nutrit enrich zophoba atratus larva new food raw materi edibl insect potenti altern food sourc high feed convers effici protein content zophoba atratus edibl insect adapt differ diet enabl sustain rear ad valu product agro industri residu studi aim evalu perform nutrit character zophoba atratus larva fed differ proport grape residu physicochem analysi diet larva aoac procedur fatti acid profil chromatograph techniqu metal non metal induct coupl plasma optic emiss spectrometri larval mass gain feed convers effici mortal rate assess replac convent diet grape residu increas lipid ash fiber content reduc protein carbohydr energi promot greater mass gain lower mortal rate reduc larval growth time among replac result second highest content calcium sodium magnesium zinc lowest content potassium phosphorus larva replac result highest amount cn cn pufa replac convent diet grape residu equival convent diet mani aspect improv sever larva perform indic nutrit valu
|
D002118;D001517
|
T123;T196;T121;T204
|
36,296,555
|
phytochem analysi understand antioxid anticanc properti methanol extract litsea glutinosa vitro vivo studi litsea glutinosa l glutinosa consid evid base medicin plant treatment cancer lead caus death worldwid studi vitro antioxid vivo anticanc properti essenti ethno medicin plant l glutinosa examin use non toxic dose phytochem analysi execut use gas chromatographi mass spectrometri vitro antioxid studi l glutinosa methanol extract lgbme reveal concentr depend antioxid properti bark extract show promis antioxid effect diphenyl picryl hydrazyl dpph assay strongest antioxid activ demonstr maximum concentr gml ic valu lgbme bht gml respect concentr total antioxid capac lgbme gml ferric reduc antioxid power assay result lgbme gml cytotox studi ld lgbme gallic acid gml gml respect vivo anticanc activ studi lgbme particular dose mgkgbw show signific cell growth inhibit decreas tumor weight increas mean surviv rate upregul reduc hematolog paramet eac ehrlich ascit carcinoma induc swiss albino mice highest cell growth inhibit observ dose mgkgbw furthermor upregul pro apoptot gene p bax downregul anti apoptot bcl observ conclus lgbme extract sever bioactiv phytoconstitu confirm antioxid anticanc properti l glutinosa
|
D000975;D032862
|
T123;T121;T044;T039;T002
|
36,296,554
|
applic curcumin emuls carrier ultrason assist prepar octenyl succin anhydrid rice starch emulsif ultrason assist prepar octenyl succin anhydrid osa rice starch curcumin investig present studi result indic encapsul effici curcumin emuls stabil osa ultrason treatment rice starch improv vitro oral digest particl size zeta potenti curcumin emuls chang signific p gt vitro digest stage stomach small intestin particl size curcumin emuls continu increas absolut potenti continu decreas work show osa pre treatment ultrason rice starch could improv curcumin bioavail increas encapsul effici stronger stabil avoid attack enzym high intens ion provid way develop new emuls base deliveri system bioactiv lipophil compound use osa starch
|
D003474;D012275
|
T121;T109;T168;T130;T002
|
36,296,553
|
trap ag perfect six coordin environ structur analysi quantum chemic calcul electrochemistri self assembl bu n mo agno bis diisopropylphenyl imino acenaphthen dpp bian dmf solut result bu n ag dpp bian mo complex complex character singl crystal x ray diffract scxrd x ray powder diffract xrpd diffus reflect dr infrar spectroscopi ir element analysi comprehens scxrd studi crystal structur show presenc ag uncommon coordin environ without clear prefer ag n ag bond quantum chemic calcul perform qualifi natur ag nag interact assign electron transit observ uv vis absorpt spectra electrochem behavior complex combin pom redox ligand signatur complex demonstr catalyt activ electrochem reduct co
|
D000073;D002245
|
T123;T197;T130;T109
|
36,296,552
|
deriv function goniothalamin goniothalamus wightii deriv target sar cov pro pro rdrp pharmacolog perspect trace altern drug phytochem promis approach viral threat emerg past two year across world herbal medicin better solut anti viral diseas pandem period goniothalamus wightii herbal plant divers bioactiv compound anticanc antioxid anti viral properti aim studi isol compound chromatographi studi function ft ir lc ms nmr c nmr h nmr result current work focus whether goniathalamin analogu could act natur anti viral molecul multipl target protein viz pro rdrp pro requir sar cov infect overal compound examin molecular dock studi perform maestro platform schroding softwar molecular dynam simul studi perform two complex major compound confirm affin across simul research suggest plant base drug high level antivir properti coronavirus howev research need verifi antivir properti
|
D054335;D000086382
|
T047;T067;T002
|
36,296,551
|
design synthesi anticanc activ molecular dock new triazol base glycosid bear thiadiazolyl indolyl arylacetamid scaffold new thiadiazol thioglycosid link substitut arylidin system synthes via heterocycl via click dipolar cycloaddit click strategi use synthesi new thiadiazol triazol hybrid glycosid base indolyl system novel hybrid molecul react azid deriv correspond acetyl glycosyl termin acetylen cytotox activ compound studi hct human colorect carcinoma mcf human breast adenocarcinoma cell line use mtt assay result show key thiadiazolethion compound triazol glycosid link p methoxyarylidin deriv free hydroxyl glycosid potent activ compar refer drug doxorubicin mcf human cancer cell dock simul studi perform check bind pattern synthes compound enzym inhibit assay studi also conduct epiderm growth factor receptor egfr result explain activ number deriv
|
D013865;D000970
|
T121;T109
|
36,296,550
|
develop polymer membran impregn poli lactic acid pla nanoparticl load red propoli rp main object studi develop character hydrophil polymer membran impregn poli lactic acid pla nanoparticl nps combin red propoli rp ultrason assist extract use obtain w v red propoli hydroalcohol extract rpe nps g mol alon incorpor rp nprp obtain use solvent emulsif diffus techniqu biopolymer hydrogel membran mnprp obtain use carboxymethylcellulos cmc nprp character perform use thermal analysi fourier transform infrar ftir total phenol tpc flavonoid content tfc antioxid activ radic scaveng assay diphenyl picrylhydrazyl radic dpph ferric reduc antioxid power frap identif quantif signific rp marker perform uplc dad nps evalu particl size polydispers index zeta potenti tpc rpe nprp mnprp mg ega g tfc valu mg eq g respect relev antioxid activ also observ frap rpe nprp mol fe g mnprp primari marker rp liquiritigenin isoliquiritigenin formononetin particl size nps nm nprp encapsul effici thermal analysi reveal high thermal stabil pla nanoparticl membran dsc reveal interact compon ftir allow character rpe encapsul nprp cmc mnprp membran load nprp fulli character antioxid capac may applic treatment skin wound
|
D011429;D053758
|
T123;T121;T073
|
36,296,549
|
transcriptom proteom character anticanc mechan natur rebeccamycin analog loonamycin breast cancer cell present studi explor anticanc effect loonamycin lm vitro vivo investig under mechan combin multi omic lm exhibit anticanc activ human tripl negat breast cancer cell promot cell apoptosi lm administr inhibit growth mda mb tumor murin xenograft model breast cancer mechanist studi suggest lm could inhibit topoisomeras dose depend manner vitro experi combin transcriptom proteom analysi lm signific effect glycan p relat signal pathway egfrpikaktmtor signal pathway enrich kegg pathway gsea data also suggest tnbc cell treat lm may regul p glycan egfrpikaktmtor signal pathway taken togeth find predict lm may target p egfrpikaktmtor signal pathway inhibit topoisomeras exhibit anticanc effect
|
D019869;D064726
|
T191;T126;T116
|
36,296,548
|
random copolym styren pendant fluorophor moieti synthesi applic fluoresc sensor nitroaromat five random copolym compris styren styren pendant fluorophor moieti name pyren naphthalen phenanthren triphenylamin molar ratio synthes employ fluoresc sensor photophys properti investig use absorpt emiss spectral analys dichloromethan solut solid state copolym possess relat quantum yield solut absolut quantum yield solid state depend fluorophor compon fluoresc studi show emiss copolym high sensit toward various nitroaromat compound solut vapor phase detect limit fluorophor nitroaromat compound dichloromethan solut prove rang moll sensor materi new hand made sniffer base fluorophor prepar electrospin appli reliabl detect nitrobenzen vapor ppm less min
|
D020058;D010616
|
T131;T121;T109
|
36,296,547
|
rgo wo heterostructur synthesi character util effici adsorb remov fluoroquinolon antibiot levofloxacin aqueous phase herein heterostructur rgo wo hydrotherm synthes character hrtem high resolut transmiss electron microscopi fesem field emiss scan electron microscopi xrd x ray diffract ft ir fourier transform infrar spectroscopi xps x ray photoelectron microscopi nitrogen physisorpt isotherm raman tga thermogravimetr analysi zeta potenti techniqu hrtem fesem imag synthes nanostructur reveal success load wo nanorod surfac rgo nanosheet prepar heterostructur util effici adsorb remov third generat fluoroquinolon antibiot ie levofloxacin lvx water adsorpt equilibrium data appropri describ langmuir isotherm model prepar rgo wo heterostructur exhibit langmuir adsorpt capac mgg kinet lvx adsorpt follow pseudo second order kinet model adsorpt lvx onto rgo wo heterostructur spontan exotherm natur electrostat interact found play signific role adsorpt lvx onto rgo wo heterostructur thus prepar rgo wo heterostructur high promis materi remov emerg contamin aqueous solut
|
D064704;D014874
|
T121;T195;T131;T109
|
36,296,546
|
format lutein caroten astaxanthin coelastrella sp isol studi effect media composit np ratio cultiv strategi format carotenoid coelastrella sp isol investig two stage process util differ media veget stage subsequ suspens medium without nitrat employ enhanc format carotenoid optim growth carotenoid content caroten lutein veget phase obtain cultiv bg media use np ratio low light intens mol control condit led optim biomass product g l low concentr astaxanthin maximum wt accumul stress condit nitrogen defici medium contain nacl light intens mol caroten lutein combin maximum wt produc non stress condit lipid analysi reveal palmit c oleic c constitut main algal fatti acid chain total fatti acid esterifi lipid constitut biomass weight result suggest coelastrella sp could also promis feedstock biodiesel product
|
D014975;D000077105
|
T123;T121;T002;T109
|
36,296,545
|
mitsunobu reaction power tool synthesi natur product review mitsunobu reaction play vital part organ chemistri due wide synthet applic consid signific reaction interconvers one function group alcohol anoth ester presenc oxid agent azodicarboxyl reduc agent phosphin renown stereoselect reaction invert stereochem configur end product one import applic mitsunobu reaction role synthesi natur product review articl focus contribut mitsunobu reaction toward total synthesi natur product highlight biolog potenti recent year
|
D001688;D010720
|
T123;T121;T104
|
36,296,544
|
explor antimicrobi ingredi psoralea corylifolia l seed relat mechan methicillin resist staphylococcus aureus abus antibiot bacteri antibiot resist becom major public healthcar issu natur plant especi tradit chines herbal medicin antibacteri activ import sourc discov potenti bacteriostat agent studi aim develop fast reliabl method screen antimicrobi compound target mrsa membran psoralea corylifolia linn seed uplc msms method appli identifi prenyl flavonoid major fraction extract psoralea corylifolia linn seed broth microdilut method use determin minimum inhibitori concentr mic differ fraction compound morpholog ultrastructur chang mrsa determin scan electron microscopi sem membran target mechan activ ingredi explor membran integr assay membran fluiditi assay membran potenti assay atp ros determin identifi eight prenyl flavonoid psoralea corylifolia linn seed antibacteri activ mechan studi show type compound uniqu destruct effect mrsa cell membran result drug resist result reveal prenyl flavonoid psoralea corylifolia linn seed promis candid develop novel antibiot agent combat mrsa associ infect
|
D055624;D029907;D000890
|
T121;T007;T002
|
36,296,543
|
agcu np format ag np catalysi cu ion room temperatur antibacteri efficaci kinet studi although facil rout prepar agcu nanoalloy nas enhanc antibacteri efficaci use ag np catalysi cu ion elev temperatur previous develop detail reaction process still unclear due fast reaction process higher temperatur work found agcu nas also synthes process room temperatur agcu nas format kinet studi use uv visibl spectra transmiss electron microscopi tem format includ cu deposit onto ag np surfac ag releas reduct agglomer form new ag nps follow redistribut na compon coalesc form larger agcu nps found spr absorpt linear time earli reaction expect pseudo first order pfo pseudo second order pso kinet neither model follow subsequ due contribut newli form ag nps agcu nas antibacteri efficaci agcu nas thus form estim continu increas whole alloy process demonstr correl antibacteri efficaci extent agcu na format ag releas
|
D053768
|
T073
|
36,296,542
|
high surfac area activ carbon deriv mango peel seed wast via microwav induc zncl activ adsorpt methylen blue dye molecul statist optim mechan studi mango mangifera indica seed ms peel mp seed mix fruit wast employ renew precursor synthes high surfac area activ carbon msmpac use microwav induc zncl activ thus applic msmpac evalu toward remov cation dye methylen blue mb aqueous environ key adsorpt factor name msmpac dose g b ph c time min inspect use desir function box behnken design bbd thus adsorpt isotherm data found correspond well langmuir model maximum adsorpt capac mgg moreov adsorpt kinet consist pseudo first order pseudo second order model spontan endotherm natur mb adsorpt msmpac surfac could infer negat g valu posit valu h respect various mechan name electrostat forc pore fill stack h bond govern mb adsorpt msmpac studi demonstr util ms mp renew precursor produc high surfac area msmpac potenti applic toward remov cation organ dye mb
|
D031022;D014874
|
T168;T131;T002
|
36,296,540
|
matter matter fast track mycobacterium abscessus drug discoveri unlik tuberculosi tb mycobacterium abscessus lung diseas high drug resist bacteri infect reliabl treatment option de novo abscessus drug discoveri urgent need hamper bacterium extrem drug resist profil leav current drug pipelin underpopul one propos strategi acceler de novo abscessus drug discoveri priorit screen advanc tb activ compound anti abscessus activ approach would take advantag greater chanc homolog drug target mycobacteri speci increas hit rate furthermor screen compound seri establish structur activ relationship pharmacokinet toler properti fast track develop vitro anti abscessus hit lead compound vivo efficaci review evalu effect strategi examin literatur found sever exampl screen advanc tb chemic matter result identif anti abscessus compound vivo proof concept effect popul abscessus drug pipelin promis new candid report valid screen advanc tb chemic matter effect mean fast track abscessus drug discoveri
|
D000073358;D009161;D009165;D014376
|
T047;T007
|
36,296,539
|
insight interact camptothecin deriv dna oligom mimick target topo inhibitor understand mechan topo inhibit organ ligand crucial sourc inform led design effect safe pharmaceut oncolog chemotherapi vast number inhibitor studi respect last decad enabl creation concept interfaci inhibitor therebi describ machineri topo inhibit central modul action machineri interfac topo idnainhibitor ternari complex interfaci inhibitor primarili kinet inhibitor form molecular complex rate time therefor contact inhibitor enzym dna essenti keep complex stabl reduc rate test hypothesi design compound use c n hydroxyethyl amino methyl substitu sn core view flexibl substitu may bind insid nick model dna stabil complex lead reduct rate ligand potenti ternari complex vivo use dock analysi molecular dynam free energi calcul level mm pbsa mm gbsa model present silico calcul structur ternari complex involv studi compound confirm suggest compound situat groov nick dna model conform number hydrogen bond compon ternari complex establish strengthen complex support view dock analysi free energi calcul receptor structur obtain md simul ternari complex dnatopo show bind constant stronger similar complex tpt cpt sn common consid strong topo inhibitor binari complex structur dna calcul compar experiment result complex solut analysi cross peak noesi spectra allow us assign dipolar interact given proton calcul structur dosi experi solut confirm strong bind ligand binari complex k mm compar k mm tpt maldi tof ms show presenc biohybrid thus evidenc occurr dna alkyl compound strong molecular complex alkyl effici way reduc time act tool caus cog brake work gear activ want highlight contribut final topo inhibit test show lower ic studi compound cpt sn
|
D002166;D011522
|
T121;T196;T109
|
36,296,538
|
elabor character thermal decomposit kinet new nanoenerget composit base hydrazin nitro triazol one nanostructur cellulos nitrat research aim develop new high energi dens ordinari nano energet composit base hydrazin nitro triazol one hnto nitrat cellulos nanostructur nitrocellulos nc nmcc elabor energet formul hntonc hntonmcc fulli character term chemic compat morpholog thermal stabil energet perform experiment find impli design hntonc hntonmcc formul good compat attract characterist densiti greater gcm impact sensit around j furthermor theoret perform calcul explo v display optim composit prepar energet composit yield excel specif impuls deton veloc increas ms hntonc ms hntonmcc moreov deep insight multi step kinet behavior prepar formul provid base measur dsc data combin isoconversion kinet method reveal energet composit undergo three consecut exotherm event satisfactori activ energi rang kjmol hntonc kjmol hntonmcc overal research display new develop nanoenerget composit base nitrat cellulos nanostructur could serv promis candid practic applic solid rocket propel composit explos
|
D006834;D049329
|
T073;T109
|
36,296,537
|
uhplc q exact orbitrap msms base untarget metabolom molecular network reveal differenti chemic constitu bulb flower fritillaria thunbergii bulb flower fritillaria thunbergii miq bft fft wide appli expector antituss tradit chines medicin studi conduct compar chemic composit plant part studi methanol extract bft fft analyz via uhplc q exact orbitrap msms feasibl use non target uhplc hrms metabolom molecular network address authent bulb flower sampl evalu princip compon analysi pca orthogon partial least squar discrimin analysi opl da heat map analysi show dissimilar metabolit bft fft result peak posit ion mode negat mode respect consid repres signific differ variabl bft fft msms base molecular network bft fft construct perform depth character peak use differ variabl total alkaloid signific differ annot paper includ seven cis de vevanin without c oh one tran de cevanin c oh thirteen tran de cevanin without c oh five cevanin n oxid five veratramin among alkaloid eight alkaloid higher fft bft content flavonoid identifi work greater fft bft content influenc differ ingredi pharmacolog activ bft fft investig futur studi
|
D031410;D000996;D000470
|
T121;T123;T109;T131;T002
|
36,296,536
|
multipl gene regul enhanc antitumor efficaci branch pcr assembl tp myc gene nanovector multipl protein involv network regul crosstalk differ signal pathway cancer propos novel strategi genom therapi branch pcr assembl gene nanovector perform network base gene regul multipl level cancer therapi valid network base multiplex gene regul genom therapi chose simultan target one tumor suppressor gene tp one oncogen myc two differ signal pathway result show compar gene nanovector target singl gene np tp np shmyc branch pcr assembl gene nanovector simultan express p protein myc shrna array np tp shmyc show enhanc antitumor efficaci mda mb cancer cell mda mb tumor bear mous model find indic feasibl effect genom therapi cancer therapi
|
D016159;D009369
|
T123;T191;T116
|
36,296,535
|
ionic dioxidovanadium v complex schiff base ligand potenti insulin mimet agent substitu effect structur stabil four dioxidovanadium v complex schiff base ligand base hydroxybenzhydrazid four differ substitut salicylaldehyd chlorosalicylaldehyd dichlorosalicylaldehyd nitrosalicylaldehyd bromo chlorosalicylaldehyd synthes describ use v triethylamin singl crystal x ray structur measur well element analys ir spectra confirm formula ionic complex proton triethylamin act counterion htea vo l hl schiff base ligand kinet stabil complex ph discuss respect neutral vanadium v complex previous studi potenti insulin mimet agent correl substitu aromat ring schiff base ligand crystal pack also stabil compound present
|
D014639;D056831
|
T131;T196;T104
|
36,296,534
|
investig chemic composit antihyperglycem antilipidem effect bassia eriophora deriv constitu umbelliferon high fat diet streptozotocin induc diabet rat studi design investig chemic profil antihyperglycem antilipidem effect total methanol extract tme bassia eriophora isol pure compound umbelliferon ufn high fat diet hfd streptozotocin stz induc diabet rat tme subject various techniqu chromatographi yield ufn diabet induc eight week hfd administr stz mgkg intraperiton experiment subject divid five group diabet control show increas level blood glucos throughout experi treatment initi four group glibenclamid glb mgkg tme mgkg mgkg isol ufn mgkg oral effect blood glucos lipid profil histolog pancreat adipos tissu assess mgkg tme produc compar signific decreas blood glucos level increas insulin level glb ufn began show better blood sugar lower effect day treatment compar howev mgkg tme ufn signific return blood glucos level diabet rat compar normal rat analysi lipid profil show hfd stz increas lipid profil paramet tme administr produc signific decreas level histopatholog examin show treatment tme ufn reveal improv cellular architectur healthi islet langerhan compact glandular cell pancreat cell distinct damag cell non treat group convers adipos tissu display appar normal polygon fat cell therefor result suggest tme potenti amelior hyperglycemia condit control lipid profil hfd stz induc diabet rat
|
D003921;D061385
|
T121;T050
|
36,296,532
|
literatur review artocarpus lacucha focus phytochem constitu pharmacolog properti plant studi shown approxim two third plant speci world medicin valu artocarpus lakoocha synonym artocarpus lacucha plant found indonesia medicin plant use treat mani diseas object articl discuss scientif investig carri lacucha name plant chemic content pharmacolog activ activ compound method design studi base articl review previous research search relev public past ten year use data pubm proquest ebsco sciencedirect googl scholar result discoveri articl result fifti relev articl investig lacucha substanc applic health field presenc secondari metabolit bioactiv compound report evid lacucha possess antidiarrh immunostimul anticholesterol hepatoprotect agent conclus mobe lacucha plant nativ north sumatra indonesia plant efficaci antioxid antibacteri antidiarrh anti inflammatori analges antinocicept schistosomicid hepatoprotect neuroprotect cytotox antiglyc anticholesterol also use anti age wound heal addit various benefit turn plant also mani activ compound use health sector especi pharmaceut field
|
D031622
|
T168;T002
|
36,296,531
|
mxene base photocatalyst degrad organ pharmaceut pollut day explor focus design two dimension nanomateri use photo catalyt environment applic among mxene base composit garner great attent owe uniqu optic mechan thermal chemic electron properti various mxene base photocatalyst invent construct varieti photocatalyt applic rang pollut degrad hydrogen evolut appli co catalyst combin assort common photocatalyst metal sulfid metal oxid metal organ framework graphen graphit carbon nitrid enhanc function photocatalyt remov organicpharmaceut pollut nitrogen fixat photocatalyt hydrogen evolut carbon dioxid convers among other high electr conduct robust phototherm effect larg surfac area hydrophil abund surfac function group mxene render attract candid photocatalyt remov pollut well improv photocatalyt perform semiconductor catalyst herein recent develop photocatalyt degrad organ pharmaceut pollut use mxene base composit deliber focus import challeng futur perspect techniqu fabric photocatalyst also cover
|
D006108;D004785;D000073396
|
T131;T196;T109
|
36,296,530
|
sustain approach use green technolog appl product valoris new perspect histori appl appl recognis cultur import fruit crop temper land area centuri human exploit develop led product thousand appl cultivar nowaday appl repres third wide cultiv fruit world total product appl process juic cider main result product regard procedur larg quantiti appl product generat tend undervalu common remain underutilis landfil inciner howev appl product proven sourc bioactiv compound name dietari fibr fatti acid triterpen polyphenol therefor applic green technolog consid order improv function appl product promot use raw materi novel product line present work provid holist view appl histor evolut characteris appl product review applic green technolog improv function sustain procedur enabl transform perish materi novel ingredi open new prospect appl potenti use consumpt
|
D027845;D014315
|
T168;T002;T109
|
36,296,529
|
peptid potenti anticarcinogen agent function can meat product willow extract aim studi demonstr can pork function meat product due presenc potenti anti cancer factor eg bioactiv peptid potenti activ cancer cell b lower content sodium nitrit willow herb extract silico assess anticanc potenti peptid vitro antiprolifer activ l ct cell line analysi perform obtain result confirm bioactiv potenti cancer prepar meat product h incub peptid obtain meat product contain lyophil herb extract concentr mgkg viabil test cell line slight decreas h hand h incub peptid obtain variant contain mgkg freez dri willow herb extract viabil intestin cancer cell decreas comparison viabil normal cell decreas
|
D008461;D032108
|
T168;T002
|
36,296,528
|
synthesi conform analysi evalu aryl bromo hydroxyphenyl benzo thiazepin potenti glucosidas andor amylas inhibitor ambid electrophil charact bromo hydroxychalcon binucleophil natur aminothiophenol exploit construct aryl bromo hydroxyphenyl benzo thiazepin structur conform aryl bromo hydroxyphenyl benzo thiazepin establish use spectroscop techniqu complement singl crystal x ray diffract method h nmr ir spectroscop techniqu confirm particip hydroxyl group intramolecular hydrogen bond interact nitrogen atom sc xrd confirm presenc six member intramolecular hydrogen bond pseudo aromat ring corrobor dft method b repres exampl gas phase compound ar c h c ar c h cl f ar c h ch ch exhibit increas inhibitori activ glucosidas compar acarbos ic ic valu respect compound f exhibit increas activ glucosidas also exhibit signific inhibitori effect amylas ic result comput approach aspect noncoval interact calcul bind energi glucosidas amylas adm absorpt distribut metabol excret bioavail properti gastrointestin absorpt blood brain barrier permeabl also present
|
D000520;D013841
|
T121;T126;T116;T109
|
36,296,527
|
potenti therapeut approach melatonin omicron variant sar cov omicron variant b covid caus diseas outbreak worldwid contagi divers mutat reduc outbreak therapeut drug adjuv vaccin appli treatment diseas howev drug shown high efficaci reduc covid sever even antivir drug shown effect research thus continu search effect adjuv therapi combin drug vaccin treat covid diseas motiv consid melatonin defens agent sar cov various uniqu properti scientif public shown signific effect melatonin treat diseas strong antioxid anti inflammatori immunomodulatori effect melatonin high safeti profil need clinic trial experi use therapeut agent omicron variant covid might immedi abl prevent develop sever symptom caus coronavirus reduc sever infect improv immun
|
D008550;D000086382
|
T121;T067;T109;T125;T047
|
36,296,526
|
chemic synthet biolog approach cancer vaccin develop cancer vaccin consid promis therapeut strategi often construct whole cell attenu pathogen carbohydr peptid nucleic acid etc howev use whole organ pathogen elicit unwant immun respons aris unforeseen reaction vaccin compon hand synthet vaccin contain antigen conjug often carrier protein overcom issu therefor review highlight synthet approach discuss sever bioconjug strategi develop antigen base cancer vaccin addit major synthet biolog approach use develop genet modifi cancer vaccin progress clinic research summar furthermor boost immun respons vaccin addit suitabl adjuv proper deliveri system essenti henc review also mention synthesi adjuv util biomateri scaffold may facilit design futur cancer vaccin
|
D019496;D009369;D009696
|
T123;T129;T121;T116;T191;T114
|
36,296,525
|
integr analysi transcriptom microrna profil reveal toxic euphorbia factor toward human colon adenocarcinoma cell line caco euphorbia factor lathyran type diterpenoid isol medic herb euphorbia lathyri l euphorbiacea associ intestin irrit toxic mechan under phenomenon still unknown object studi evalu transcriptom mirna profil human colon adenocarcinoma caco cell respons euphorbia factor l efl efl whole transcriptom mrna microrna mirna obtain use second generat high throughput sequenc technolog respons efl treatment h differenti express gene metabol pathway enrich gene structur chang analyz compar refer genom sequenc h treatment mirna mrnas differ express efl group control group mirna mrnas differenti express efl group control use cluster ortholog protein enrich sequenc mrnas shown main involv transcript post translat modif protein turnov chaperon signal transduct mechan intracellular traffick secret vesicular transport cytoskeleton differenti express mrna function pathway enrich transmembran transport cell extravas il signal pathway apoptosi cell cycl differenti express mirna efl caus chang structur gene includ altern splice insert delet singl nucleotid polymorph studi reveal under mechan respons toxic efl intestin cell base transcriptom mirna profil gene express structur
|
D028481;D000230;D003110;D004224;D035683
|
T123;T109;T191;T114;T002
|
36,296,524
|
advanc thermoelectr composit consist conduct polym filler differ architectur stretchabl wireless power increas high demand field smart devic flexibl robot electron skin thermoelectr devic abl convert heat electr due seebeck effect make promis candid wearabl electron therefor high perform conduct polym base composit urgent requir flexibl wearabl thermoelectr devic util low grade thermal energi review mechan optim strategi polym base thermoelectr composit contain filler differ architectur introduc recent advanc develop thermoelectr composit contain dimension filler compon present outlook
|
D011108;D000076251
|
T104;T122;T073
|
36,296,523
|
effect cultur condit fatti acid profil bacteria lipopolysaccharid genus pseudomona gc ms analysi ionic liquid base column profil bacteri fatti acid well establish techniqu identifi classifi bacteria cultiv condit may affect biosynthesi therebi chang fatti acid profil bacteria effect cultur condit fatti acid compon pseudomona aeruginosa pao pseudomona aeruginosa atcc pseudomona aeruginosa polyresist pseudomona putida align genus pseudomona fatti acid lipopolysaccharid pseudomona aeruginosa pao also examin effect cultiv condit follow use agar blood agar media characterist temperatur c c c respect analysi made st rd th day follow inocul addit quantit differ also experienc qualit differ fatti acid profil detect newli appear fatti acid due chang environment factor applic ionic liquid base column unveil new possibl analys fatti acid gc ms experi bacteri fatti acid profil valid result respons linear limit detect limit quantif system suitabl intraday interday repeat accuraci show high separ effici ionic liquid base column analys
|
D052578;D016958
|
T120;T007;T103
|
36,296,522
|
function ultrasmal iron oxid nanoparticl weight magnet reson imag tumor hypoxia hypoxia common biolog condit mani malign solid tumor play imper role regul tumor growth impact treatment therapeut effect therefor hypoxia assess great signific predict tumor develop evalu prognosi among plenti exist tumor diagnosi techniqu magnet reson imag mri offer certain distinct featur free ioniz radiat provid imag high spatial resolut studi develop fluoresc traceabl hypoxia sensit weight mri probe fe met cy via conjug notabl hypoxia sensit metronidazol moieti cy dye ultrasmal iron oxid fe nanoparticl result vitro vivo experi show fe met cy excel perform relax biocompat hypoxia specif import obvious signal enhanc hypox area indic probe great feasibl sens tumor hypoxia via weight mri promis result may unlock potenti fe nanoparticl weight contrast agent develop clinic hypoxia probe
|
D053758;D009369;D058185
|
T191;T130;T073
|
36,296,521
|
natur compound battl microorgan linalool purpos articl present recent studi antimicrobi properti linalool mechan action cell detoxif process current trend employ compound present essenti oil support antibiot therapi becom increas popular natur occur monoterpen constitu essenti oil undergo detail studi understand detail effect human bodi independ dose correl current use pharmaceut one compound linalool common found mani herb use flavor black tea compound excel fragranc addit cosmet enhanc preserv effect formul use act anti inflammatori mild skin lesion previous studi shown extrem import due broad spectrum biolog activ ie antioxid anti inflammatori anticanc cardioprotect antimicrobi among opportunist hospit strain activ gram negat bacteria mechan action linalool microorgan still intens investig one key aspect linalool research biotransform suscept detoxif process determin
|
D009822;D000890
|
T121;T109
|
36,296,520
|
benzimidazol bear thiosemicarbazon deriv act potent amylas glucosidas inhibitor synthesi bioactiv screen molecular dock studi diabet mellitus one chronic metabol diseas past year research group synthes evalu librari heterocycl analog glucosidas amylas enzym found encourag result current studi compris evalu benzimidazol bear thiosemicarbazon antidiabet agent librari fifteen deriv synthes character via differ spectroscop techniqu hrei ms nmr screen glucosidas amylas enzym deriv exhibit excel good biolog inhibitori potenti deriv ic ic found potent among seri compar standard drug acarbos ic respect deriv may potenti serv lead candid develop new therapeut repres structur activ relationship carri molecul main base upon pattern substitu phenyl ring moreov silico dock studi carri investig activ bind mode select deriv target enzym
|
D065089;D013882
|
T121;T109
|
36,296,519
|
develop high select sensit fluoresc probe imag rna dynam live cell rna imag great import understand complex spatiotempor dynam cellular function consider effort devot develop small molecul fluoresc probe rna imag howev report studi main focus improv photost permeabl long emiss wavelength compat live cell imag rna probe less attent paid select detect limit class probe high select sensit rna probe still rare avail studi new set styryl probe design synthes aim upgrad detect limit maintain select lead probe quid rna among newli synthes compound quid promis candid limit detect lod valu quid rna ngml solut properti signific improv comparison quid spectroscopi cell imag studi demonstr advantag quid commerci avail rna stain probe syto rnaselect high select sensit rna imag addit quid exhibit excel photost low cytotox use quid global dynam rna reveal live cell import quid found potenti applic detect rna granul live cell collect work provid ideal probe rna imag anticip power tool may creat new opportun investig under role rna rna granul live cell
|
D005456;D012313
|
T130;T114
|
36,296,516
|
high resolut bioassay profil complement sensit resolut pancreat lipas inhibitor screen rapid accur screen bioactiv compon complex natur product remain major challeng studi screen platform pancreat lipas pl inhibitor establish combin magnet bead base ligand fish high resolut bioassay profil platform well valid use mixtur standard compound ie epigallocatechin gallat egcg luteolin schisandrin dose effect relationship high resolut bioassay profil demonstr standard mixtur differ concentr compound screen pl inhibitor green tea extract concentr mgml independ high resolut bioassay profil perform sampl pre treatment ligand fish green tea extract concentr mgml specif enrich simplifi consequ screen high resolut bioassay profil result three pl inhibitor ie egcg gallocatechin gallat gcg epicatechin gallat ecg rapid identifi complex matrix establish platform prove capabl enrich affin binder elimin nonbind sampl pre treatment ligand fish overcam technic challeng high resolut bioassay profil aspect sensit resolut meanwhil high resolut bioassay profil possess abil direct bioactiv assess parallel structur analysi identif separ establish platform allow accur rapid screen pl inhibitor great facilit natur product base drug screen
|
D008049;D002392
|
T121;T126;T116;T109
|
36,296,515
|
integr mn znfe g c n boost spatial charg generat separ effici photocatalyst dispos dye organ matter water bodi becom signific sourc pollut pose health risk human worldwid rise water demand dwindl suppli harm compound must isol wastewat kept aquat environ research present hydrotherm synthesi manganes dope zinc ferrit mn znfe nanoparticl nps nanocomposit ncs sulfur dope graphit carbon nitrid mn znfe g c n describ sampl morpholog structur bond featur investig use sem xrd ftir techniqu two phase photocatalyt degrad studi wt mn dope znfe nps mn znfe wt g c n ncs mb carri find photocatalyst maximum effici mn znfe nps mn znfe g c n ncs exhibit best photocatalyst effici phase one phase two respect enhanc photocatalyt activ mn znfe g c n ncs could attribut synergist interact mn znfe g c n ncs interfac result effect transfer separ photo induc charg therefor effici afford ecolog secur modifi znfe dope mn homogen g c n result current research suggest synthet ternari hybrid mn znfe g c n ncs may effect photocatalyt system degrad organ pollut wastewat
|
D062065;D004785
|
T131;T083;T069
|
36,296,514
|
delta tetrahydrocannabinol product impur due increas concern regard unidentifi impur delta tetrahydrocannabinol thc consum product studi use nuclear magnet reson nmr high perform liquid chromatographi hplc mass spectrometri ms conduct investig product ten thc product includ distil readi use vapor cartridg analyz result yield find test product contain sever impur concentr far beyond declar certif analysi product thc synthet product synthes cannabidiol cbd valid concern regard presenc impur product unknown effect human bodi compound problem appar inadequ test product produc independ laboratori
|
D002185;D002188
|
T121;T002;T167;T109
|
36,296,513
|
glycoconjug quinolin deriv use c posit sugar strategi improv select cytotox function compound base warburg effect increas demand glucos tumor cell target drug deliveri strategi develop seri new glycoconjug increas abil interact glut transport respons transport sugar cancer cell synthes glycoconjug perform use c posit sugar unit least involv format hydrogen bond various aminoacid residu transport carbohydr moieti connect hydroxyquinolin scaffold via triazol linker obtain compound sever vitro biolog test perform use hct mcf cancer cell well nhdf neo healthi cell highest cytotox cancer cell line mtt test note glycoconjug triazol quinolin attach triazol nitrogen atom glucos unit direct carbon c posit compound select analog glycoconjug form c anomer posit glucos experi edg inhibitor shown glut involv transport glycoconjug result apoptosi cell cycl analys flow cytometri confirm new type glycoconjug show pro apoptot properti without signific affect chang distribut cell cycl moreov glycoconjug abl decreas clonogen potenti cancer cell inhibit migrat capac cell intercal dna
|
D000970;D011804
|
T121;T109
|
36,296,512
|
enhanc insecticid effect interfac behavior nicotin hydrochlorid solut vesicl surfact nicotin hydrochlorid nct good control effect hemiptera pest poor interfaci behavior hydrophob leaf lead practic applic studi vesicl solut eco friend surfact sodium diisooctyl succin sulfon aot prepar pesticid carrier nct physic chemic properti nct load aot vesicl nctaot investig techniqu dynam light scatter dls small angl x ray scatter sax cryogen transmiss electron microscopi cryo tem result show pesticid load encapsul effici nctaot respect size nctaot vesicl nm sax surfac tension result indic structur nctaot vesicl still exist low surfac tension even dilut time contact angl nctaot alway mean could wet surfac cabbag leaf well consequ nctaot vesicl could effect reduc bounc pesticid droplet vitro releas experi show nctaot vesicl sustain releas properti nct nctaot releas h h insecticid activ assay aphid reveal aot vesicl exhibit insecticid activ could synergist insecticid effect nct load nct thus nctaot vesicl signific improv insecticid effici nct potenti applic agricultur product activ
|
D007306;D011663
|
T131;T121;T123;T109
|
36,296,511
|
optim treatment cannabi extract formul gain via knowledg terpen content via enrich specif select monoterpen monoterpenoid differ therapeut effect medic cannabi infloresc extract general attribut differ administr form result pharmacokinet hypothes differ may extend composit actual consum drug cannabinoid terpen content compar commerci cannabi infloresc n decarboxyl extract n infloresc decarboxyl extract produc n cannabinoid content preserv extract signific loss terpen evid main volatil monoterpen monoterpenoid repres loss loss chang total terpen content proport monoterpen total terpen monoterpenecannabinoid ratio terpen defici might impair extract pharmacolog efficaci might contribut patient prefer infloresc smoke argu valid term whole plant full spectrum extract creat mislead assumpt extract repres pharmacolog profil sourc infloresc furthermor reduc divers extract loss differ sativa type indica type enrich cannabi extract select terpen may provid suitabl solut generat safe precis reproduc drug tailor cannabinoid terpen content care select terpen ad enabl tailor made extract adjust various medicin aim differ popul
|
D002188;D064086;D002186;D006213
|
T121;T167;T073;T109;T131;T093;T002
|
36,296,510
|
supramolecular design strategi water solubl diphenylguanidin cyclodextrin polym inclus complex diphenylguanidin dpg wide use secondari acceler vulcan natur rubber nr latex howev low water solubl high toxic limit use high end nr product studi water solubl inclus complex dpg cyclodextrin polym cdp term dpg cdp prepar supramolecular interact character use fourier transform infrar spectroscopi h nmr scan electron microscopi uv vis spectroscopi techniqu comparison dpg water solubl dpg cdp great enhanc water solubl host molecul molar ratio dpg cd unit cdp determin c bind constant dpg cdp found lmol uv vis spectroscopi propos method form inclus complex high potenti use water solubl vulcan acceler promis
|
D014867;D012408
|
T121;T073;T109;T197;T122
|
36,296,509
|
effect salicyl acid concentr post treatment time direct system chemic defens respons maiz zea may l follow exogen foliar applic salicyl acid sa play critic role allerg reaction plant pathogen acquir system resist thus far although research conduct direct effect differ concentr sa chemic defens respons treat plant part leav multipl post treatment time research report systemat effect non treat part root therefor examin direct system effect sa concentr time follow foliar applic chemic defens respons maiz varieti two fulli expand leav experi maiz leav treat differ sa concentr mm presenc defens chemic enzym treat leav non treat root measur differ time point h follow sa foliar applic result show direct system effect sa treatment leaf chemic defens respons relat sa concentr time measur spray sa treat leav total phenol content increas direct time point h follow foliar applic mm sa dimboa dihydroxi methoxi h benzoxazin h one content direct enhanc h follow mm sa treatment polyphenol oxidas superoxid dismutas activ direct enhanc h follow mm sa treatment wherea peroxidas catalas activ increas h follow applic mm sa non treat root dimboa content polyphenol oxidas activ enhanc systemat h follow mm sa foliar treatment superoxid dismutas activ enhanc h follow mm sa applic total phenol content peroxidas catalas activ decreas particular concentr differ time measur sa treatment conclud sa foliar applic mm produc strong chemic defens respons maiz optim induct time h follow foliar applic
|
D003313;D020156
|
T168;T121;T002;T109
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.