PMID
int64 35.7M
36.4M
| Title/Abstract
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|---|---|---|---|
36,293,606
|
burnout qualiti work life among municip worker motiv econom factor play mediat role studi analyz relationship burnout qualiti work life among municip worker subject higher level stress emot exhaust impact occup health context covid pandem sampl municip worker relationship burnout qualiti work life test consid isol mediat effect feel contribut product combin effect two mediat repres feel contribut product receiv appropri salari main find includ negat associ three dimens burnout emot exhaust feel cynic sens less effect mediat contribut product appropri salari also detect import mediat role associ effect feel contribut work well well paid relat burnout syndrom dimens low effect qualiti work life futur action public author public manag need highlight creat innov human resourc manag framework flexibl work organ remuner plan base product goal aim improv balanc person life work
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D000086382;D002055
|
T047;T067;T048
|
36,293,605
|
determin consum behavior reduc pesticid residu veget fruit northern thailand pesticid residu veget northern thailand exceed maximum residu limit establish european union therefor improv knowledg behavior reduc pesticid residu veget fruit vf would reduc risk exposur pesticid studi aim investig contribut factor consum behavior reduc pesticid residu vf differ knowledg attitud behavior reduc pesticid residu vf consum live rural urban communiti chiang mai thailand also investig cross section studi carri august octob particip data collect particip use googl form questionnair result indic pesticid free top rank consider vf purchas linear regress analysi found factor associ consum behavior reduc pesticid residu vf total knowledg score beta standard error se ci total attitud score se ci co morbid se ci type vf purchas se ci frequenc vf purchas se ci price vf product se ci get inform broadcast tower villag se ci
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D010573;D010575
|
T131
|
36,293,604
|
traumat dental injuri among year old schoolchildren unit arab emir studi aim evalu preval factor relat traumat injuri perman incisor year old children emir ajman unit arab emir
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D018677
|
T037
|
36,293,603
|
price decis make dual channel healthcar servic suppli chain consid channel accept price ceil public welfar given increas number onlin healthcar channel play essenti role suppli method healthcar servic suppli chain hssc paper studi price decis make problem dual channel hssc consid channel accept price ceil public welfar hssc healthcar institut establish tradit offlin channel onlin channel provid healthcar servic health condit consid public welfar healthcar institut employ sum formula econom revenu patient surplus describ total revenu healthcar servic channel base stackelberg game develop decentr suppli chain model maxim suppli chain member revenu employ karush kuhn tucker optim condit deriv analyt express optim servic price includ function public welfar coeffici channel accept final conduct extens numer analys various system paramet verifi optim price decis make strategi analyt result indic healthcar servic price close relat patient channel accept public welfar coeffici govern price ceil polici public welfar coeffici strong influenc servic price total revenu increas decreas econom revenu hssc accept onlin channel essenti factor care consid construct dual channel hssc improv patient accept onlin channel conduc develop improv sustain dual channel hssc
|
D003132;D003695
|
T078;T093;T097;T081;T058;T057
|
36,293,602
|
myopia depress among middl school student china mediat role wear eyeglass compar non myopic student myopic student face barrier learn eg inabl see blackboard clear social eg victim teas social exclus violenc may lead increas stress anxieti frustrat high preval myopia depress among school age children natur rais question great polici relev myopic student vulner mental health problem depress paper shed light question analyz data china educ panel survey larg scale survey china middl school student analysi first quantifi associ myopia sampl student depress status measur wide adopt ces scale adjust potenti confound factor explor whether myopia depress relationship mediat wear eyeglass cost effect mean vision correct base data middl school student analysi reveal myopic student score standard deviat higher ces scale non myopic counterpart advers effect myopia sever relat disadvantag student older student like suffer myopia depress lower perform student student poorer famili medic analysi show wear eyeglass suppress myopia depress relationship complet offset advers effect myopia
|
D005139;D009216
|
T047;T074
|
36,293,601
|
long act revers contracept use rural urban resid among women nigeria studi examin tempor trend associ rural urban resid use larc among women use method contracept secondari object examin whether associ vari time studi secondari analysi data collect perform monitor action pma project nigeria among women age n n n weight multivari logist regress analys examin associ place resid likelihood larc overal specif type util use weight multivari logist regress show women use method contracept rate larc util urban area signific lower rural area ci attribut main high util rate implant women urban area like use intrauterin devic iud ci compar rural area convers use implant signific lower among women urban area ci adjust predictor observ reduct albeit signific differ odd overal larc iud implant use urban compar rural area use larc increas associ larc use place resid also differ pma survey year need program polici close gap dispar overal specif larc util rate base place resid
|
D003270;D003267
|
T061;T121;T039
|
36,293,600
|
impact intermedi good import energi effici empir evid chines citi improv energi effici critic way solv energi shortag environment problem achiev goal doubl carbon china expand import integr global valu chain import trade improv energi effici topic extrem import solv current energi problem promot sustain econom develop base panel data prefectur level citi china paper use super sbm model measur total factor energi effici citi investig impact intermedi good import energi effici fix effect model instrument variabl method iv studi find intermedi good import contribut increas urban energi effici mechan test indic intermedi good import affect energi effici technolog spillov effect intermedi good type diversif effect accord heterogen analysi effect intermedi good import energi effici evid eastern china citi low topograph relief medium popul scale high absorpt capabl analysi spatial spillov effect sdm model show import intermedi good promot energi effici local citi radiat energi effici improv neighbor citi
|
D057217;D003246
|
T081;T078
|
36,293,599
|
sexual histori document screen adolesc femal suicid ideat emerg depart adolesc mental ill often seek care emerg depart ed like engag riski behavior substanc abus unprotect sex increas risk sexual transmit infect sti unintend pregnanc non consensu sex retrospect studi femal age year present pediatr ed chief complaint suicid ideat februari may electron medic record review demograph psychiatr histori sexual histori test pregnanc sti primari outcom document presenc absenc prior sexual activ secondari outcom includ document aspect sexual histori pregnanc sti test perform ed elig patient document sexual histori report sexual activ sexual histori document associ patient age race ethnic insur gender ed provid histori anxieti recent suicid attempt associ lack sexual histori document p sexual activ patient document contracept use pregnanc test perform patient sexual activ patient patient sti test ed test occur sexual histori document p conclus half femal suicid ideat ed document sexual histori document complet often miss import element includ screen pregnanc sti non consensu sex contracept use sinc ed visit provid import opportun address reproduct health need high risk popul work need determin way improv provid document sexual health screen
|
D059020;D012749
|
T033;T047
|
36,293,598
|
effect resist train protocol physic perform bodi composit bone metabol system homeostasi patient diagnos parkinson diseas pilot studi parkinson diseas pd neurodegen disord character motor impair correl loss bone miner densiti studi aim analyz effect resist train bone metabol system homeostasi bodi composit physic perform peopl pd thirteen subject age pd diagnosi recruit particip perform neuromuscular test bodi composit assess blood sampl analysi baselin week train period train session last min three time week particip signific improv time go p lt sit stand p lt domin peg board p lt domin foot reaction time p lt function reach test p lt show better pressur foot distribut left forefoot p lt hindfoot p lt increas cervic right later bend angl p lt protocol affect bone metabol marker osteocalcin p lt calcium p lt pth p lt c termin telopeptid ctx p lt vitamin p lt eleven week resist train improv manual dexter static dynam balanc reaction time cervic rom reduc bone loss peopl pd
|
D055070;D010300
|
T061;T047
|
36,293,597
|
status worker health behavior associ occup characterist health behavior studi investig differ unhealthi lifestyl behavior ulb worker nonwork demonstr associ ulb occup characterist among worker cross section studi use data korea nation health nutrit examin survey sociodemograph data chi squar test use analyz categor variabl odd ratio or confid interv cis ulb estim use poisson regress model adjust age sex educ level household incom variabl use current smoke status heavi drink physic inact worker associ increas risk current smoke adjust aor ci heavi drink aor ci physic inact aor ci compar nonwork among worker differenti risk ulb accord occup characterist follow skill manual worker self employ worker worker work gt hweek higher risk engag ulb occup categori paid worker worker work hweek respect worker show higher risk ulb nonwork risk ulb differ accord occup characterist highlight need addit studi detail occup health manag
|
D016272
|
T078;T091
|
36,293,596
|
prenat co exposur manganes mercuri lead neurodevelop children first year life lead pb mercuri hg manganes mn neurotox littl known neurodevelopment effect associ simultan prenat exposur metal aim studi associ pb hg mn prenat level joint separ neurodevelop first year life method pb hg mn blood lead level measur pregnant women offspr neurodevelop assess bayley scale infant develop iii one three six twelv month metal mean blood level gl pb hg mn mean languag cognit motor develop score infant age low averag averag multilevel model result show languag develop coeffici offspr decreas point per gdl increas matern blood lead level p magnitud aforement associ increas children matern blood mn lt gl p hg gt gl p cognit motor develop negat associ matern blood pb level latter statist signific interact term pb mn hg includ p prenat exposur low pb level may impair infant neurodevelop first year life even expos hg defici mn
|
D008628;D011297
|
T131;T196;T037
|
36,293,595
|
characteris risk assess metal contamin dust fall vicin construct wast dump beij studi larg construct wast dump beij china use studi area nineteen effect atmospher dust sampl collect mass fraction metal element ca fe al mg mn zn cr cu v pb ni co cd determin sampl use icp ms pollut potenti ecolog risk level differ heavi metal evalu use enrich factor geo accumul index potenti ecolog risk assess method result show ca fe al mg content dust fall consider high account total mass analys metal cd zn main metal contamin dust fall vicin construct wast dump follow cu mn cd zn cu mn content construct wast signific impact atmospher pollut within dump moreov cd largest contribut comprehens ecolog risk pose heavi metal dust fall determin primari ecolog risk factor atmospher environ vicin construct wast dump
|
D019216;D004785
|
T131;T196
|
36,293,594
|
applic decis tree model predict outcom non intens inpati hospit covid mani studi identifi predictor outcom inpati coronavirus diseas covid especi intens care unit howev retrospect studi appli regress method evalu risk death worsen health recent new studi base conclus retrospect studi appli machin learn method studi appli machin learn method base decis tree method defin predictor outcom intern medicin unit prospect studi design main result first variabl evalu predict intern normal ratio measur relat prothrombin time follow immunoglobulin respons model allow threshold determin continu blood haematolog paramet drew path toward outcom model perform accuraci sensit specif valid k fold repeat cross valid result suggest machin learn approach could help clinician obtain inform could use alert diseas progress patient covid research explor accept result physician current practic analyz impact machin learn guid decis patient outcom
|
D000086382
|
T047;T067
|
36,293,593
|
time end life patient start specialis palliat care denmark descript regist base cohort studi increas number patient refer specialis palliat care spc order benefici recommend last three month cohort studi aim describ time end life initi spc treatment explor potenti region variat use nation regist data danish hospit spc team includ patient start spc treatment explor time end life longer three month descript statist use summaris data generalis linear model use assess variat among five danish region total patient includ ci three month end life capit region denmark ci three month end life versus ci north denmark region conclud patient live shorter period time recommend three month initi spc treatment neither optim patient care healthcar system geograph variat region shown indic differ practic patient group resourc result warrant investig promot optim spc treatment
|
D010166;D012017
|
T061;T058;T170;T097
|
36,293,592
|
coagul floccul primari clarif effici solut low densiti microplast remov wastewat microplast mp remov wastewat investig use various type dose commerci coagul pix pax floccul fpm pel fct primari clarif wastewat treatment plant wwtp dose fpm pix pel caus small mps transfer main settl sludg mp dose ml fmpm dose fct pax caus mps transfer float sludg mp dose ml paxm effici mp remov wastewat highest ml paxm generat primari sludg low mp content could safe manag subsequ stage sludg treatment highest dose pix signific increas remov p po cod fpm fct result effici ammonium remov disturb wastewat composit may negat affect biolog treatment effect remov mp mechan part wwtp result coagul floccul enabl safe use excess sludg agricultur purpos
|
D018508;D064751;D014874
|
T104;T197;T131;T052;T057
|
36,293,591
|
relationship eye frailti physic social psychologicalcognit weak among communiti dwell older adult japan studi investig relationship eye frailti physic social psychologicalcognit weak among older adult japan particip communiti dwell older adult women measur handgrip strength walk speed skelet muscl mass addit physic social psychologicalcognit frailti survey use questionnair eye frailti self check use assess eye frailti exploratori confirmatori factor analys employ verifi valid eye frailti self check eye frailti preval relat factor investig conduct binomi logist regress analysi eye frailti depend variabl factor analysi result show model could construct two factor visual acuiti contrast visual field model good fit accept support valid self check construct kihon checklist variabl signific relationship eye frailti regard relationship eye frailti subordin item kihon checklist social withdraw odd ratio confid interv cognit function ci depress mood ci signific eye frailti consid factor reflect exist social psychologicalcognit frailti
|
D000073496
|
T033;T184;T046
|
36,293,590
|
psychoanalyt intervent abus parent opportun children mental health research extens shown peopl experi maltreat childhood develop mental disord psychosoci adjust problem mani case becom maltreat adult prevent child maltreat treat abus children abus parent therefor press public health issu establish uk children act child develop enhanc remain famili whenev child safeti assur thus develop prevent intervent program purpos repair whenev possibl child parent relationship social prioriti narrat review focus psychoanalyt studi relat intrapsych dynam therapeut intervent physic abus parent role transgener transmiss abus parent narcissist fragil crucial psychoanalyt intervent focus help parent work past pain experi narcissist vulner parent child psychotherapi mental base treatment found preval scarc literatur regard intens individu psychoanalyt treatment within framework attach theori brief intervent develop howev prove effect parent suffer experi maltreat sever neglect childhood long term parent child psychotherapi result prove effect
|
D008603;D002649
|
T041;T048
|
36,293,589
|
preval anxieti burnout cope mechan among clinic year medic undergradu student univers kebangsaan malaysia amidst covid pandem studi aim determin preval anxieti burnout cope mechan among clinic year undergradu medic student univers kebangsaan malaysia ukm coronavirus diseas covid pandem total clinic year undergradu medic student ukm particip cross section studi may juli self administ questionnair consist question particip sociodemograph data item dass cbi brief cope distribut chi squar spearman correl test use calcul correl coeffici anxieti burnout cope mechan preval anxieti burnout respect signific differ percentag student extrem sever anxieti presenc absenc burnout vs p lt among three cope mechan avoid cope signific posit moder correl presenc anxieti r p lt presenc burnout r p lt meanwhil cope neither approach avoid posit weak correl presenc burnout r p preval anxieti burnout concern increas anxieti burnout among student may negat impact aspect person profession academ live earli recognit prevent measur emphasis prevent negat ramif
|
D013337;D000086382;D002055
|
T047;T067;T097;T048
|
36,293,588
|
use predict model techniqu assess core temperatur adapt heart rate sweat rate thermal sensat heat acclimat heat acclim assess adapt rectal temperatur rec critic follow heat acclimat haz heat acclim ha associ exercis perform safeti howev feasibl valid method need identifi purpos studi predict adapt rec heart rate hr sweat rate sr thermal sensat ts use predict model techniqu twenti five male endur athlet age vo max mlkg min complet three trial consist min run vvo max hot environ trial highest hr ts sr rec end trial record follow baselin trial particip perform haz follow post haz trial complet five day ha follow post ha trial decis tree indic cut point hr lt bpm sr gt lh ts predict lower rec two three variabl met cut point probabl accuraci show lower rec greater adapt rec observ two three variabl met cut point c compar one c p lt zero c p lt specif two three variabl met cut point predict lower rec result suggest use heart rate sweat rate thermal sensat adapt indic adapt rec benefici follow heat adapt especi field set practic noninvas method
|
D013542;D001833
|
T040;T031
|
36,293,587
|
relat continu chronic patient primari secondari care doctor studi public healthcar network six latin american countri despit relat continu rc doctor key care qualiti chronic patient particular fragment healthcar system like mani latin america la littl known rc attribut particular regard specialist aim aim analys chronic patient percept rc primari pc secondari sc care doctor record chang public healthcar network six la countri analysi two cross section studi appli ccaena questionnair chronic patient n conduct argentina brazil chile colombia mexico uruguay depend variabl rc pc sc doctor consist trust effect communic synthet index base rc attribut descript multivari analys perform although rc index high especi pc countri level argentina uruguay low perceiv consist pc sc doctor colombia chile sc doctor mexico reveal import area improv rc index sc doctor increas chile mexico sc doctor consist colombia decreas studi reveal import gap achiev rc doctor particular sc requir structur organis reform
|
D063127;D010820
|
T058;T097
|
36,293,586
|
uncov role mind autonom motiv across physic educ leisur time extend tran contextu model mind assum foster abil consist act line one authent self skill found enhanc student autonom motiv behavior educ context howev evid regard mind integr exist conceptu framework tran contextu model scarc therefor present studi aim evalu role mind student autonom motiv school leisur time context overal n student year sd indic self report mind perceiv need support physic educ autonom motiv physic educ leisur time well perceiv behavior control attitud subject norm intent toward physic activ physic activ addit measur physiolog n student use acceleromet path model analys reveal inclus mind substanti improv tran contextu model fit perceiv autonomi support posit predict mind turn predict autonom motiv physic educ leisur time attitud subject norm perceiv behavior control furthermor mediat analys reveal signific indirect effect mind physiolog self report physic activ base result mind consid key factor foster student motiv becom physic activ
|
D010806;D064866
|
T065;T041
|
36,293,585
|
social stigma depress among asymptomat covid carrier shanghai china mediat role entrap decad sinc advent novel coronavirus covid coexist social stigma depress symptom depress hereaft covid patient mention mechan involv remain unclear studi aim explor stigma affect depress mid pandem period
|
D057545;D000086382
|
T033;T047;T067
|
36,293,584
|
facebook suicid behaviour user experi suicid note live stream griev prevent strategi scope review facebook repres new dimens global inform share suicid behaviour attempt increas report facebook scope review explor various aspect suicid behaviour associ facebook discuss challeng prevent measur
|
D013405;D061108
|
T033;T170
|
36,293,583
|
estim health effect cigarett smoke durat south africa paper deepen empir analysi health effect smoke use averag treatment effect treat atet regress discontinu design rdd estim impact smoke durat health paper estim effect cigarett smoke health exogen increas probabl smoke relat ill health individu smoke certain number year use nation incom dynam survey nid studi find probabl report poor health andor suffer smoke relat diseas increas year smoke magnitud effect higher smoke relat diseas rather self assess health consid vari across time socioeconom status differ health outcom effect robust sever differ parametr non parametr model use rdd paper also find evid discret jump poor health individu smoke year result suggest polici design reduc current level cigarett smoke may desir impact creat current futur public health benefit
|
D000073865
|
T055
|
36,293,582
|
realli elus ill post covid ill percept recoveri strategi themat analysi substanti number patient report persist symptom covid infect call post covid syndrom limit research patient perspect post covid symptom way recov qualit studi explor ill percept recoveri strategi patient hospitalis covid differ recov non recov patient investig semi structur depth interview held particip patient recov non recov month hospit discharg data interpret use reflex themat analysi four overarch theme identifi symptom hospit discharg ii impact covid daili life self ident iii uncertainti covid iv deal covid former hospitalis post covid patient seem difficulti make sens ill gain control recoveri major non recov particip continu suffer most weak fatigu dyspnoea cognit dysfunct notabl differ ill belief observ recov non recov particip
|
D000086382
|
T047;T067
|
36,293,581
|
effect teach mini handbal non linear pedagogi differ socioeconom context pilot studi mini handbal among sport includ part school physic educ chile improv children motor skill motiv adher healthi activ lifestyl respons concern countri high level childhood obes end non linear pedagogi nlp use develop motor skill mini handbal school context howev socioeconom differ influenc develop children motor skill consid determin whether methodolog appli everyon aim present observ studi describ compar effect previous appli nlp methodolog two contrast socioeconom context determin whether help develop motor skill mini handbal school context levin test use determin homogen varianc p lt distribut data normal kruskal walli h statist test use analys within group data addit mann whitney u test appli comparison group result show signific improv acquisit expect motor skill specif mini handbal addit shorten gap evidenc group train process signific differ end progress therefor investig nlp equal effect schoolchildren two opposit socioeconom context
|
D063766;D013177
|
T033;T047;T056
|
36,293,580
|
self report experi midwiv work uk across three phase covid cross section studi matern servic postpon due natur servic howev pandem result wide rang signific chang work practic servic paper aim describ uk midwiv experi work covid pandem studi form part larger multipl phase research project use cross section design base onlin survey onlin survey use valid psychometr tool measur work relat qualiti life wellb cope burnout well open end question understand experi staff work pandem paper report qualit data collect open end question qualit data subject themat analysi four main theme emerg relentless stresspressur reconfigur servic protect self other workforc challeng key conclus midwiv experienc reduct qualiti work life signific stress throughout pandem due rang factor includ staf shortag restrict place women partner chang servic manag support compound workforc pressur exist prior pandem research recommend consult front line midwiv relat possibl chang practic workforc plan prepar crise pandem ensur equit support manag access practic psycholog support
|
D008880;D000086382
|
T047;T067;T091;T097
|
36,293,579
|
role differ fraction freshwat biofilm photodegrad methyl orang bisphenol aqueous solut freshwat biofilm play import role migrat transform organ pollut especi illumin condit nonetheless role variabl fraction freshwat biofilm eg extracellular polymer substanc ep microbi cell origin biofilm promot photodegrad trace organ pollut remain larg unclear studi two contamin ie methyl orang mo bisphenol bpa select role differ fraction freshwat biofilm photodegrad perform investig dose mgl ss biofilm harvest effluent receiv river direct photodegrad rate mo bpa increas time time respect river biofilm ep contain aromat fraction chromogen group conjug structur biofilm harvest less eutroph pond might respons enhanc photodegrad process quench experi suggest ep fraction deriv river biofilm dose ep major reactiv oxygen speci photodegrad mo bpa meanwhil ep deriv pond biofilm oh predomin respons enhanc photodegrad batch experiment result suggest cell ep river biofilm could collabor interact enhanc preserv reactiv speci protect microb thus facilit photoact biofilm result might suggest biofilm generat eutroph waterbodi effluent receiv river could play import role photodegrad process contamin
|
D018441;D004785
|
T131;T007
|
36,293,578
|
influenc biostimul use sustain agricultur antifung protect chemic composit winter wheat grain field studi conduct south eastern poland n e aim identifi chemic composit winter wheat grain upon foliar applic biostimul planton bio contain nettl willow extract show antifung activ main chemic composit spatial distribut wheat grain character raman spectroscopi techniqu establish appli biostimul hydro thermal condit chang chemic composit grain studi year similar chemic composit grain achiev plant treat synthet prepar includ intens extens variant second group term increas fatti acid content consist grain plant treat biostimul planton bio planton bio natur crop planton bio biofol plex futur use biostimul crop product includ contain salicyl acid nettl extract appear promis altern synthet crop protect product
|
D014908;D000935
|
T168;T121;T195;T002
|
36,293,577
|
impact biochar use repair histor build public health subject matter manuscript concern analysi identif microorgan pose threat human health particular mold fungi occur histor build surfac infect fungal spore pose threat structur health visitor histor build profession work research undertaken fill defect build partit supplementari layer biochar order elimin partial reduc possibl contamin develop harm mold fungi design cement mixtur biochar use filler task elimin caus lead develop harm mold fungi microbiolog analys surfac wall air select build carri applic supplementari biochar layer inhibitori properti materi use presenc growth mold fungi observ averag number microorgan isol test partit decreas consequ use materi signific influenc air qualiti room import protect health peopl work well visit histor build
|
D016902
|
T069;T080
|
36,293,576
|
prerequisit covid predict review factor affect infect rate sinc year coronavirus diseas covid emerg domin topic discuss public research domain intens research carri sever aspect covid includ vaccin transmiss mechan detect covid infect infect rate factor awar public relat covid infect factor enabl public adher standard oper procedur full elucid correl differ factor infect rate facilit effect measur minim risk covid infect polici maker enforc henc paper aim provid comprehens analyt review differ factor affect covid infect rate furthermor review analys factor direct indirect affect covid infect risk physic distanc ventil face mask meteorolog factor socioeconom factor vaccin host factor sar cov variant avail covid test critic analysi perform differ factor provid quantit qualit studi last challeng correl infect risk factor predict risk covid infect discuss recommend research work intervent outlin
|
D000086402;D000086382
|
T005;T067;T047
|
36,293,575
|
compar effect east asian tradit medicin childhood simpl obes systemat review network meta analysi childhood obes lead various comorbid usual persist adulthood increas socioeconom burden absenc clear effect treatment east asian tradit medicin eatm therapi wide use aim analyz compar effect safeti eatm techniqu children simpl obes network meta analysi nma twelv databas search random control trial rcts evalu effect eatm childhood simpl obes individu eatm rank base surfac cumul rank curv risk bias individu studi public bias nma evalu thirti three rcts includ acupunctur chuna chuna plus acupressur cup plus acupressur herbal medicin hm hm plus acupunctur signific reduc bmi compar lifestyl manag base treatment rank cup plus acupressur optim bmi reduct compar non medic manag follow chuna hm qualiti evid individu find usual moder low serious advers event eatm report cup plus acupressur might larg benefici effect chuna hm probabl moder benefici effect reduc bmi children simpl obes
|
D063766;D008518;D015670
|
T033;T047;T091;T061
|
36,293,574
|
knowledg attitud practic survey among nurs care worker involv care older adult earli stage covid pandem japan japan undergo popul age nurs care worker play import role support older adult communiti particular critic covid pandem howev knowledg attitud practic kap among nurs care worker regard covid fulli elucid
|
D000086382
|
T047;T067
|
36,293,573
|
workplac mistreat health condit prior covid south korea cross section studi studi examin relationship workplac mistreat includ discrimin abus overwork health problem among full time worker prior coronavirus diseas covid outbreak south korea
|
D017132;D000086382
|
T047;T067;T082
|
36,293,572
|
empower digit transform result structur blend learn job train practic physician germani background practic physician focus structur qualif basic digit compet far howev current gatekeep implement digit technolog need empower proactiv take part ongo digit transform process present studi investig structur blend learn train practic physician germani enhanc physician knowledg central aspect digit transform includ awar person possibl act attitud toward digit empow mindset method particip n self assess knowledg item point likert scale attitud item point likert scale toward digit transform begin end train mancova conduct result particip report increas everi knowledg domain repres larg effect hedg g attitud part shift toward empow mindset decreas insecur toward technolog legal ethic aspect digit transform hedg g howev prepared digit transform remain low conclus general hypothes confirm present job train desir effect practic physician knowledg attitud nevertheless addit empower support essenti
|
D010820
|
T097
|
36,293,571
|
mixtur risk assess complex real life mixtur panoramix project human involuntarili expos hundr chemic either contamin environ food ad intent daili product complex mixtur chemic may pose risk human health one goal european union green deal zero pollut ambit toxic free environ tackl exist gap chemic mixtur risk assess provid scientif ground support implement adequ regulatori measur within eu suggest deal challeng characteris real life chemic mixtur determin extent transfer environ human via food water mother foetus establish high throughput whole mixtur base vitro strategi screen real life complex mixtur organ chemic extract human use integr chemic profil suspect screen togeth effect direct analysi evalu human blood level chemic mixtur might concern children develop develop web base readi use interfac integr hazard exposur data enabl compon base mixtur risk estim concept form basi green deal project panoramix whose ultim goal progress mixtur risk assess chemic
|
D045424;D004787;D009930
|
T109;T103;T069
|
36,293,570
|
transport high risk infecti substanc packag transport categori infecti specimen spain infecti specimen materi pathogen includ categori european agreement concern intern carriag danger good road adr must transport follow pack instruct p tripl packag system must includ leakproof receptacl impact resist packag preserv integr sampl prevent releas content event transport adr pack instruct p indic primari receptacl secondari packag must withstand without leakag intern pressur less kpa temperatur rang c c studi analyz various packag system avail spanish market transport infecti sampl determin compli overpressur test difficult meet accord pack instruct p five packag system select studi none secondari packag test show adequ characterist withstand pressur leakproof test case primari receptacl contain sampl direct capabl withstand intern pressur kpa without leakag must use exampl test tube screw cap howev manufactur distributor specif alway clear readili avail regard health laboratori carrier personnel awar adr regul packag characterist safe secur handl transport high risk categori infecti materi
|
D019064;D014186
|
T068;T056;T169;T073
|
36,293,569
|
eat disord hospit school age children adolesc covid pandem cross section studi discharg record development age itali eat disord ed character behavior cognit aspect result signific impair individu well covid pandem consequ negat impact healthcar servic peopl mental health particular development age difficulti cope situat could impact eat behavior therefor aim studi assess ed hospit trend pandem peak evalu whether influenc retrospect cross section studi conduct hospit discharg form patient year old piedmont region northern itali overal hospit age gender specif rate due ed occur compar occur sinc reduct overal hospit total proport ed admiss doubl signific hospit rate increas observ femal age group non signific increas observ male age group increas hospit ed investig might tip iceberg yet acknowledg
|
D000086382;D001068
|
T047;T067;T048
|
36,293,568
|
mean experi end life patient famili caregiv hospit home transit constructivist ground theori studi studi explor mean experi patient termin chronic diseas caregiv face immin death home environ hospit discharg qualit studi use constructivist ground theori particip individu termin chronic ill discharg home famili caregiv data gather depth interview field note compar analysi conduct identifi categori code accord charmaz theori sampl consist particip three inter relat data categori emerg float accept resist perceiv proxim death analys end perspect encount death life understood accept path love let go love want stay categori translat reconstruct face end life occur home environ amid immin death life gain intens talk finitud life configur opportun see life perspect give voic individu face mishap termin ill foster path comfort death health profession opportun provid structur human care ethic attitud defenc human digniti
|
D017028;D000069341
|
T099;T098;T058;T097
|
36,293,567
|
work wast hazard mitig strategi use wast picker inner citi durban inform wast picker citi across global south divert signific amount tonnag landfil divers contribut toward sustain environ better public health practic inform worker global deriv livelihood collect sort sell recycl wast south africa grow recognit valuabl work wast picker carri despit howev inform worker remain larg unrecognis often stigmatis suffer lack social protect link work lack recognit protect creat specif occup hazard wast picker use ethnograph method studi explor physic socio psycholog hazard emerg wast pick street inner citi durban south africa found wast picker major women develop mitig strategi risk better understand occup hazard wast pick shape local context work street enabl recognit knowledg wast picker alreadi hold regard mitig strategi insight occup hazard import consid municip integr wast picker happen way ensur access social protect inform worker
|
D018505;D012037
|
T068;T057
|
36,293,566
|
mutat hotspot ugta locus may associ gilbert syndrom affect taiwanes popul gilbert syndrom main diagnos genet analysi primarili detect mutat promot region ugta gene howev research conduct caucasian popul studi studi han popul taiwan investig possibl mutat could caus gilbert syndrom studi compris test group taiwanes individu gilbert syndrom healthi taiwanes individu control group extract dna blood sampl use axiom genom wide twb array plate genotyp singl nucleotid polymorph snps subject detect snps signific shift allel frequenc snps among locat ugta region detect snps high correl locat near first exon ugta ugta ugta ugta use snps input machin learn algorithm develop predict model studi reveal good associ snps detect gilbert syndrom henc studi provid refer diagnos gilbert syndrom taiwanes popul futur
|
D005878
|
T047
|
36,293,565
|
correl immunolog histopatholog featur gene express base classifi colon cancer patient purpos studi evalu associ four distinct histopatholog featur tumor infiltr lymphocyt mucin differenti tumor stroma ratio plus tumor bud two gene express base classifi consensus molecular subtyp cms plus colorect cancer intrins subtyp cris four histopatholog featur retrospect score hematoxylin eosin section invas part primari tumor stage ii iii colon cancer patient two independ cohort amc ajcc ac icam rna base cms cris assign independ obtain patient conting tabl construct test use test statist signific odd ratio confid interv calcul presenc tumor infiltr lymphocyt mucin phenotyp gt mucin surfac area strong correl cms p lt p cris p p lt presenc mucus associ cms mucus present cms tumor p lt although clear associ tumor stroma ratio cms establish studi p still cms tumor score stroma low indic cms tumor identifi sole base stromal content higher bud count seen cms cris b tumor p p associ measur paramet seen cris subtyp analysi reveal clear associ histopatholog featur cms cris subtyp howev identif distinct molecular subtyp sole base histopatholog prove infeas combin molecular morpholog featur could potenti improv patient stratif
|
D003110;D015179
|
T191
|
36,293,564
|
clinic efficaci flt inhibitor patient acut myeloid leukemia flt mutat common genom alter detect acut myeloid leukemia aml wors clinic prognosi high frequent flt mutat togeth side effect associ clinic prognosi make flt promis treatment target provok advanc flt inhibitor recent numer flt inhibitor activ develop thus outcom aggress subtyp aml signific improv recent midostaurin gilteritinib approv frontlin treatment aml therapeut agent recur diseas unit state food drug administr recent numer promis clinic trial attempt seek appropri manag frontlin set relapsedrefractori diseas stem cell transplant aml review follow numer clinic trial use flt inhibitor frontlin therapi relapsedrefractori condit mainten therapi stem cell transplant cumul data flt inhibitor would import clinic evid manag flt inhibitor aml patient flt mutat
|
D000970;D015470;D018380
|
T061;T121;T191;T109
|
36,293,563
|
cheminformat studi structur bactericid activ latest generat lactam widespread pathogen raman spectra oxacillin oxn carbenicillin cbc azlocillin azl report first time togeth full assign normal mode calcul use densiti function theori dft method blyp exchang correl function coupl g g p basi set molecular dock studi perform five penicillin includ oxn cbc azl subsequ chemic reactiv correl effici toward specif pathogen strain reveal combin frontier molecular orbit fmo data molecular electrostat potenti mep surfac bactericid activ test confirm coupl speci gram posit gram negat use disk diffus method addit surfac enhanc raman spectroscopi ser princip compon analysi pca base resistogram hydrophila propos clinic relev insight result synergist cheminformat vibrat studi cbc azl
|
D000080911;D047090
|
T170;T195;T109
|
36,293,562
|
brain effect sc nanophytosom rotenon induc rat model parkinson diseas proof concept mitochondria target therapi mitochondria attract target fight neurodegen diseas due import function cell particular close relationship function connect among brain region mitochondri perform work present mitochondria target therapi design modul function mitochondri respiratori chain lipidom paramet affect neurodegener includ parkinson diseas pd therapi support sc nanophytosom construct membran polar lipid codium tomentosum elderberri anthocyanin enrich extract sambucus nigra l sc nanophytosom nanos vesicl high negat surfac charg preserv properti includ anthocyanin flavylium cation form condit mimic gastrointestin tract ph chang sc nanophytosom phospholipid mgl eae extract deliv drink water rotenon induc pd rat model show signific posit outcom disabl motor symptom associ diseas ex vivo assay perform two brain portion one compris basal ganglia cerebellum bg cereb cerebr cortex c cortex region result show rotenon induc neurodegener increas synuclein level bg cereb portion compromis mitochondri respiratori chain function brain portion well evidenc decreas respiratori control rate complex activ rotenon induc pd phenotyp also associ chang superoxid dismutas catalas activ depend brain portion treatment sc nanophytosom revert synuclein level antioxid enzym activ valu detect control anim moreov mitig mitochondri dysfunct posit outcom respiratori control rate activ individu respiratori complex fatti acid profil membran phospholipid therefor sc nanophytosom promis tool support mitochondria target therapi neurodegen diseas
|
D010300;D060766
|
T047;T167
|
36,293,561
|
molecular mechan rsv air pollut interact scope review rsv one major infecti agent paediatr relationship air pollut frequent observ howev molecular basi interact spars report sought systemat review exist bodi literatur identifi knowledg gap answer question molecular mechan impli air pollut rsv interact onlin databas search origin studi publish august focus molecular mechan interact studi chart narrat synthesi base upon three expect direct influenc facilit viral entri alter viral replic inappropri host reaction identifi studi publish without notic increas number studi perform human n anim n mix n model analys main cigarett smoke n particul matter n nanoparticl n carbon black n data damag epitheli barrier support hypothesi facilit viral entri one studi also report acceler viral entri upon rsv conjug particul matter air pollut may result predomin necrosi apoptosi effect increas viral load report similar air pollut mitig epithelium function decreas ifn clara cell secretori protein level decreas immun respons immun respons might also diminish due decreas viral uptak alveolar macrophag suppress function dendrit cell hand exuber inflammatori respons might trigger air pollut provok airway hyperrespons ahr prolong lung infiltr tissu remodel includ format emphysema ahr mediat most increas ifn rant concentr risk emphysema relat activ il mcp mmp mmp axi signific lack evid molecular basic rsv air pollut interact may present serious problem regard futur action air pollut effect major knowledg gap concern air pollut most influenc cigarett smoke investig mechan facilit acut infect wors diseas cours sinc might help plan short term especi non pharmacolog intervent mechan inadequ respons infect may lead prolong cours acut infect long term sequela thus far evid insuffici regard broad complex interact futur studi focus common mechan stimul various air pollut comparison influenc differ contamin various concentr
|
D000397;D000393;D011656;D004646;D018357
|
T080;T131;T069;T047;T046
|
36,293,560
|
phase behavior ionic liquid base aqueous two phase system environment friend separ medium ionic liquid il base aqueous two phase system atp attract long term attent grow number scientist engin phase equilibrium data il base atpss import basi design optim chemic reaction separ process involv il articl provid recent signific progress made field highlight possibl direct futur develop effect compon salt agent il phase behavior il base atpss summar discuss detail main focus phase behavior atpss use il expect provid meaning valuabl inform may promot research applic
|
D052578
|
T120;T103
|
36,293,559
|
effect sub minimum inhibitori concentr imipenem colistin express biofilm specif antibiot resist virul gene acinetobact baumannii sequenc type antibiot suboptim dose promot biofilm format develop antibiot resist under molecular mechan howev investig report effect sub minimum inhibitori concentr sub mic imipenem colistin gene associ biofilm format biofilm specif antibiot resist multidrug toler clinic strain acinetobact baumannii sequenc type st compar transcriptom analysi perform untreat biofilm biofilm treat sub mic dose imipenem colistin rna sequenc data show gene differenti express imipenem colistin treat biofilm cell respect among differenti express gene deg gene upregul exclus imipenem colistin treat biofilm cell respect upregul gene includ encod matrix synthesi pgab multidrug efflux pump novel fimbrial protein homoserin lacton synthas abai upregul biofilm associ gene might enhanc biofilm format treat sub mic antibiot downregul gene includ encod dna gyras novel ribosom protein novel ribosom releas factor rrf downregul biofilm cell treat imipenem colistin downregul gene affect protein synthesi turn slow cell metabol make biofilm cell toler antibiot investig also found small rnas srnas differenti express biofilm regardless antibiot treatment srna show highest express level biofilm srnas regul gene express associ biofilm format may turn affect express biofilm specif antibiot resist summari biofilm cell expos sub mic dose colistin imipenem coordin gene respons result increas biofilm product multidrug efflux pump express slowdown metabol lead drug toler biofilm target antibiot induc repress biofilm specif gene repres new strategi develop innov effect treatment biofilm associ infect caus baumannii
|
D040981;D000151
|
T047;T007
|
36,293,558
|
explor concept vivo guid tissu engin singl stage surgic procedur rodent model sever malform lack nativ tissu treatment option limit aim expand tissu vivo use bodi bioreactor develop sustain singl stage procedur autolog tissu reconstruct malform surgeri autolog micro epithelium skin integr plastic compress collagen degrad knit fabric mesh sixti three scaffold implant nine rat histolog mechan analys week transplant tissu integr cell expans prolifer inflamm strength elast evalu time vivo valid vitro bladder wound heal model day vivo observ keratinocyt prolifer top transplant remodel collagen neovascular within transplant week transplant fulli integr surround tissu tensil strength elast retain whole studi period vitro model multilay epithelium cover defect week autolog micro epitheli transplant allow cell expans reorgan vivo without convent pre oper vitro cell propag method easi perform requir handl outsid oper theater
|
D023822;D012377
|
T061;T015
|
36,293,557
|
tissu sheet engin use human umbil cord deriv mesenchym stem cell improv diabet wound heal diabet foot ulcer common chronic diabet complic human umbil cord deriv mesenchym stem cell huc mscs wide use regen medicin owe multipot easi avail develop poli lactic co glycol acid plga base scaffold creat huc msc tissu sheet vitro immunostain show huc msc tissu sheet form thick solid tissu sheet abund extracellular matrix ecm diabet wound mice treat without either huc msc tissu sheet huc msc inject fiber reveal huc msc tissu sheet transplant promot diabet wound heal improv epitheli collagen deposit blood vessel format matur allevi inflamm compar observ group taken collect find suggest huc mscs cultur plga scaffold improv diabet wound heal collagen deposit angiogenesi provid novel effect method cell transplant promis altern diabet skin wound treatment
|
D045164;D059630;D003920
|
T061;T047;T025
|
36,293,556
|
epigenet pregnanc condit snapshot roll event epigenet modif dna methyl affect matern health gestat period furthermor pregnanc drive rang physiolog molecular chang potenti contribut patholog condit pregnanc relat risk factor includ multipl environment behavior hereditari factor impact matern dna methyl long last consequ identif epigenet pattern link poor pregnanc outcom crucial sinc chang dna methyl pattern long term effect review provid overview epigenet chang influenc pregnanc relat molecular program gestat diabet immun respons pre eclampsia effort close gap current understand regard interact environ genet fetus pregnant woman
|
D011225;D016640
|
T047;T046
|
36,293,555
|
xanthohumol rich hop extract diminish endotoxin induc activ tlr signal human peripher blood mononuclear cell studi healthi women infect gram negat bacteria still among lead caus infect relat death sever studi suggest chalcon xanthohumol xn found hop humulus lupulus possess anti inflammatori effect singl blind placebo control random cross design studi assess oral intak singl low dose mg xn deriv xn rich hop extract xn affect lipopolysaccharid lps induc immun respons peripher blood mononuclear cell pbmcs ex vivo normal weight healthi women n clinicaltrialsgov nct determin associ molecular mechan lps stimul pbmcs isol particip h intak placebo h result signific induct pro inflammatori cytokin releas signific attenu particip consum xn xn depend attenu proinflammatori cytokin releas less pronounc h lps stimul releas scd signific reduc timepoint lps depend activ htlr transfect hek cell signific dose depend suppress xn rich hop extract attenu cell co challeng scd taken togeth result suggest even one time intak low dose xn consum xn rich hop extract suppress lps depend stimul pbmcs relat interact hop compound cdtlr signal cascad
|
D027582;D047188;D011427
|
T002;T109
|
36,293,554
|
identif express analysi dsx posit transcript regul iag black tiger shrimp penaeus monodon doublesex dsx polymorph transcript factor dmrts famili involv male sex trait develop control sexual dimorph differ development stage arthropod howev transcript regul dsx gene larg unknown decapod studi report cdna sequenc pmdsx penaeus monodon encod amino acid polypeptid share mani similar dsx homolog close relationship phylogeni differ speci demonstr express male sex differenti gene dsx predomin express p monodon testi pmdsx dsrna inject signific decreas express insulin like androgen gland hormon iag male sex determin gene increas express femal sex determin gene also identifi flank region pmiag two potenti cis regulatori element cres pmdsx transcript dual luciferas report analysi truncat mutagenesi reveal pmdsx overexpress signific promot transcript activ pmiag promot via specif cre result suggest pmdsx engag male reproduct develop posit regul transcript pmiag specif bind upstream promot pmiag provid theoret basi explor sexual regul pathway evolutionari dynam dmrt famili gene p monodon
|
D033561;D061385
|
T121;T204
|
36,293,553
|
synthesi biolog activ molecular dock chimer peptid target opioid nop receptor recent mix opioidnop agonist came spotlight favor function profil promis outcom clinic trial novel analges studi report two novel chimer peptid incorpor fragment tyr c lys phe phe asp nh rp cyclic peptid high affin opioid receptor mop kop respect conjug peptid ac ryyrik nh known ligand nociceptinorphanin fq receptor nop yield rp ryyrik nh kw rp gli ryyrik nh kw vitro chimer kw gain affin kop henc becom dual kopmop agonist kw behav mix mopnop agonist low nm affin henc kw select vivo experi intrathec administr peptid mice elicit antinocicept effect hot plate test action sensit univers opioid receptor antagonist naloxon select nop antagonist sb rotarod test reveal kw administr alter mice motor coordin perform comput studi conduct two chimera investig structur determin basi experiment activ includ role gli spacer
|
D000701;D011957
|
T121;T116;T192;T109;T131
|
36,293,552
|
aberr transferrin ferritin upregul elicit iron accumul oxid inflammag caus ferroptosi undermin estradiol biosynthesi age rat ovari upregul nf b activ induc nitric oxid synthas first demonstr intric mechan report herein novel mechan unravel proteom valid vitro vivo studi aberr age associ upregul ovarian transferrin ferritin rat ovari ovarian mass serum estradiol titer plummet ovarian labil ferrous iron total iron level escal age rat oxid stress marker nitritenitr nitrotyrosin hydroxi nonen accumul age ovari due aberr upregul ovarian transferrin ferritin lightheavi chain iron regulatori protein irp mediat transferrin receptor tfr ferritin inhibit estradiol biosynthesi ovarian granulosa cell vitro via upregul nuclear factor kappa light chain enhanc activ b cell nf b pp induc oxid inflammatori factor induc nitric oxid synthas ino vivo studi demonstr age associ activ nf b induc upregul ino tumor necrosi factor tnf downregul keap mediat nuclear factor erythroid relat factor nrf induc decreas glutathion peroxidas gpx observ aberr transferrin ferritin upregul trigger iron accumul via upregul irp induc tfr culmin nf b ino mediat ovarian oxi inflamm age serum estradiol decrement natur age rat iron accumul effect ferroptosi relat protein includ gpx tfr nrf keap ferritin heavi chain testicular ferroptosi indic trigger ferroptosi young rat intraovarian inject adenovirus express iron regulatori protein upregul ovarian nf bino downregul gpx novel find contribut prompt translat research ovarian age associ iron metabol age associ ovarian diseas
|
D016328;D000079403
|
T129;T116;T043
|
36,293,551
|
transcriptom landscap pediatr astrocytoma central nervous system tumor common solid neoplasia childhood repres one lead caus cancer relat mortal tumor aris astrocyt cell astrocytoma frequent diagnos accord histolog patholog characterist classifi four categori howev addit layer molecular classif consid dna sequenc tumorigenesi associ gene idh hfa recent incorpor classif guidelin although mutat hfa found exclus subtyp grade iv pediatr astrocytoma mutat idh gene rare children year age transcriptom profil astrocytoma adult children extens studi howev scarc inform profil pediatr popul consid status tumorigenesi associ gene therefor report transcriptom landscap four grade pediatr astrocytoma rna sequenc found sever well document biolog function associ misregul gene four grade astrocytoma well addit biolog pathway among four grade astrocytoma found share misregul gene could implic tumorigenesi final identifi transcript signatur almost grade astrocytoma could use transcript base identif method
|
D001932;D001254
|
T191
|
36,293,550
|
role glycolysi fatti acid synthesi activ cell modul potenti dendrit cell stimul tlr ligand allergen fusion protein train immun respons base metabol epigenet chang innat immun cell de facto innat immun memori therefor great interest vaccin develop previous studi recombin fusion protein rflaa betv combin adjuv toll like receptor tlr ligand flagellin flaa major birch pollen allergen bet v singl molecul signific suppress allerg sensit vivo also chang metabol myeloid dendrit cell mdcs within studi immun metabol effect rflaa betv mdc activ elucid line result well character tlr ligand rflaa betv increas glycolysi suppress oxid phosphoryl differ extent make rflaa betv suitabl model studi immun metabol effect tlr adjuv vaccin vitro pretreat mdcs cerulenin inhibitor fatti acid biosynthesi led decreas rflaa betv induc anti inflammatori cytokin interleukin il helper cell type th relat cytokin il p pro inflammatori cytokin il unaffect interest pretreat glutaminas inhibitor bptes result increas il decreas il p secret leav il unchang inhibit glycolyt enzym hexokinas deoxyglucos led decreas investig cytokin il il p il inhibitor mitochondri respir effect rflaa betv induc il level either enhanc secret il oligomycin decreas il p antimycin extracellular flux measur mdcs show strong enhanc glycolysi rflaa betv stimul slight increas respiratori shutdown use antimycin rflaa betv stimul mdcs secret direct antimicrobi substanc mtor fatti acid metabol depend manner co cultur rflaa betv stimul mdcs cd cell suppress bet v specif th respons shown depend fatti acid synthesi effector function rflaa betv activ mdcs main reli glycolysi fatti acid synthesi also signific contribut rflaa betv mediat cytokin secret product antimicrobi molecul modul cell respons
|
D051198;D014612
|
T129;T121;T116;T192
|
36,293,549
|
genom artistv autonom bioinformat tool annot natur transposon sequenc genom annot transpos element transposon dynam field genom various tool assign support bioinformat endeavor develop describ genom artist v gav softwar conceiv map artifici transposon mobil insert mutagenesi project new function gav qualifi tool map annot natur transposon nts long read contig assembl genom tabular export map annot data high throughput data analysi generat list flank sequenc around coordin insert around target site duplic comput consensus sequenc flank sequenc key asset gav addit develop set script enabl user annot nts har annot offer flybas drosophila melanogast genom convert sequenc file fasta raw extract junction queri sequenc essenti nts map herein present applic gav preliminari annot p element hobo class ii nts copia retrotransposon genom melanogast strain horezulaperi horezu romania sequenc nanopor technolog laboratori use contig assembl flye tool q qualiti filter read result suggest gav reliabl autonom tool abl perform map annot nts genom sequenc long sequenc technolog gav open sourc softwar compat linux mac os window avail github repositori dedic websit
|
D019295;D029721
|
T123;T116;T091
|
36,293,548
|
network pharmacolog analysi experiment valid kaempferol treatment ischem stroke inhibit apoptosi regul neuroinflamm involv neutrophil kaempferol natur plant flavonoid compound neuroprotect effect ischem stroke specif mechan remain unclear current studi appli comprehens strategi combin network pharmacolog experiment evalu explor potenti mechan kaempferol treatment cerebr ischemia first network pharmacolog analysi identifi biolog process kaempferol suggest kaempferol may part help treat ischem stroke regul apoptosi inflammatori respons evalu efficaci kaempferol acut stage ischem stroke elucid effect possibl mechan cell apoptosi neuroinflamm involv neutrophil result show kaempferol could signific reduc modifi neurolog sever score mnss reduc volum cerebr infarct degre cerebr edema term anti apoptosi kaempferol could signific reduc number tunel posit cell inhibit express pro apoptot protein promot express anti apoptot protein kaempferol may play anti apoptot role regul express level bdnf trkb pikakt signal pathway addit found kaempferol inhibit neuron loss activ glial cell well express level inflammatori protein cox classic pro inflammatori signal pathway tlrmydnf b ischem brain reduc mpo activ neutrophil count peripher blood regul neutrophil aggreg infiltr ischem brain western blot reveal kaempferol regul activ jakstat signal pathway neutrophil ischem brain studi show kaempferol inhibit activ number neutrophil rat peripher blood brain may relat regul jakstat pathway
|
D018696;D000083242;D002545
|
T121;T047;T046;T169
|
36,293,547
|
comput dock reveal co evolut c carbon deliveri enzym divers plant protein modular function regul multipl cellular activ prokaryot eukaryot consequ higher plant adapt arid thermal condit c photosynthesi carbon fixat process involv multi enzym work coordin fashion howev enzym interact whether co evolv parallel maintain interact differ plant remain elus date report find global protein co evolut relationship local dynam co vari site shift key c photosynthet enzym found select key c photosynthet enzym global pairwis co evolut event exist form function coupl besid protein protein interact enzym may suggest unknown function carbon deliveri process pepc ppck regul pair pocket format interact interfac necessari function featur distinct anoth well known regul pair c photosynthesi name ppdk ppdk rp pocket necessari find facilit discoveri novel protein regul type contribut expand knowledg c photosynthesi
|
D002244;D010788
|
T121;T070;T196;T039;T044
|
36,293,546
|
sex differ lead differenti gene express pattern therapeut efficaci mucopolysaccharidosi iva murin model receiv aav gene therapi adeno associ virus aav vector base therapi effect correct diseas patholog murin model mucopolysaccharidos howev immunogen limit therapeut effect immun respons target capsid protein transduc cell gene therapi product ultim result loss enzym activ inher differ male versus femal immun respons signific impact aav gene transfer aim investig sex differ immun respons aav gene therapi mice mucopolysaccharidosi iva mps iva mps iva mice treat differ aav vector express human n acetylgalactosamin sulfat sulfatas galn demonstr robust antibodi respons femal mice result subsequ decreas galn enzym activ less therapeut efficaci tissu patholog relat male mice thyroxin bind globulin promot neutral antibodi titer femal mice approxim fold higher male mice galn enzym activ level approxim fold lower overal male mice treat aav base gene therapi show patholog improv femur tibial growth plate ligament articular cartilag determin contrast differ patholog score compar femal cardiac histolog reveal failur normal vacuol femal contrast complet correct male mice find promot need determin sex base differ respons aav mediat gene therapi relat develop treatment mps iva
|
D009085;D009083;D002811
|
T047;T126;T116
|
36,293,545
|
dr select trail variant dr b function tumor penetr irgd peptid enhanc antitumor activ glioblastoma trail tnf relat apoptosi induc ligand deriv potenti anticanc therapi due select induct apoptosi tumor cell upon bind death receptor dr dr previous generat dr select trail mutant variant dr b overcom receptor depend resist tumor cell trail current studi improv antitumor activ dr b fusion tumor home irgd peptid known enhanc drug penetr tumor tissu obtain bispecif fusion protein dr b irgd exhibit dual affin dr integrin v receptor dr b irgd penetr u tumor spheroid faster dr b demonstr enhanc antitumor effect human glioblastoma cell line tg u well primari patient deriv glioblastoma neurospher vitro addit dr b irgd high effect xenograft mous model u human glioblastoma cell line vivo suggest dr b irgd may becom promis candid target therapi glioblastoma
|
D053221;D005909
|
T123;T191;T116
|
36,293,544
|
high molecular weight dextran type exopolysaccharid produc novel apilactobacillus waqarii improv metabol syndrom vitro vivo analys metabol syndrom lead medic concern affect one billion peopl worldwid metabol syndrom defin cluster risk factor predispos individu cardiovascular diseas diabet stroke recent year appar role gut microbiota metabol syndrom drawn attent microbiom engin therapeut specif lactic acid bacteria lab harbor benefici metabol characterist includ product exopolysaccharid microbi byproduct recent isol novel fructophil lactic acid bacterium flab apil actobacillus waqarii strain hbw honeybe gut found produc dextran type exopolysaccharid ep object studi explor therapeut potenti new dextran relat metabol syndrom find reveal dextran abil improv viabil damag ht intestin epitheli cell exhibit antioxid properti vivo analys demonstr reduct bodi weight gain serum cholesterol level mice supplement dextran compar control respect addit blood glucos level decreas follow dextran supplement increas non treat mice overal studi display biotherapeut potenti novel ep improv metabol syndrom individu compon warrant investig
|
D024821
|
T047
|
36,293,543
|
fatti acid amid hydrolas defici associ deleteri cardiac effect myocardi ischemia reperfus mice ischem cardiomyopathi lead inflamm left ventricular lv dysfunct anim studi provid evid cardioprotect effect endocannabinoid system includ cardiomyocyt adapt inflamm remodel cannabinoid type receptor cb defici led increas apoptosi infarct worsen lv function ischem cardiomyopathi aim studi investig possibl cardioprotect effect endocannabinoid anandamid aea ischemia reperfus ir therefor fatti acid amid hydrolas defici faah mice subject repetit daili min left anterior descend arteri lad occlus consecut day interest faah mice show stigmata enhanc inflamm cardiomyocyt loss stronger remodel persist scar deterior lv function compar wild type wt litterm endocannabinoid also activ ppar peroxisom prolifer activ receptor ppar mediat effect aea elimin ppar antagonist gw iv faah mice lv function assess use mode echocardiographi immunohistochem analysi reveal apoptosi macrophag accumul collagen deposit remodel hypertrophi determin cardiomyocyt area heart weighttibia length molecular analys involv taqman rt qpcr immun cell analyz fluoresc activ cell sort fac import collagen deposit reduc wt level faah mice treat gw chemokin ligand ccl express signific higher faah mice compar wt follow higher macrophag infiltr infarct area revers gw treatment besid restor antioxid properti contractil element ppar antagon also revers hypertrophi remodel faah mice final faah mice show substanti downregul ppar compar wt suggest compensatori mechan endocannabinoid also ligand ppar activ caus lipotox lead cardiomyocyt apoptosi studi give novel insight role endocannabinoid act via ppar hypothes increas endocannabinoid may partial detriment effect cardiomyocyt surviv due ppar activ
|
D017202;D018487;D003324;D009202;D002186
|
T121;T047;T046;T109
|
36,293,542
|
heparanas increas podocyt surviv autophag flux adriamycin induc injuri kidney glomerular filtrat barrier gfb enrich heparan sulfat hs proteoglycan contribut permselect endoglycosidas heparanas cleav hs henc appear involv pathogenesi kidney injuri glomerulonephr recent report nonetheless heparanas overexpress preserv glomerular structur kidney function experiment model adriamycin induc nephropathi elucid mechan under heparanas function podocyt key gfb cell util human podocyt cell line transgen mice overexpress heparanas notabl podocyt overexpress heparanas h demonstr signific higher surviv rate viabil exposur adriamycin hydrogen peroxid compar mock infect v podocyt immunofluoresc stain kidney cryo section cultur h v podocyt well immunoblot protein extract cultur cell reveal exposur toxic injuri result signific increas autophag flux h podocyt revers heparanas inhibitor roneparstat sst heparanas overexpress also associ substanti transcript upregul autophagi gene bcn atg atg follow adriamycin treatment moreov cleav caspas attenu h podocyt expos adriamycin indic lower apoptot cell death h vs v podocyt collect find suggest podocyt elev level heparanas promot cytoprotect
|
D050199
|
T025
|
36,293,541
|
zn catalyz regioselect chemoselect reduct aldehyd keton imin oper conveni zn catalyz synthesi alcohol reduct aldehyd keton unsatur aldehydesketon report rare exampl use mild sustain hbpin reduct catalyt reduct carbonyl compound absenc acid base hydrolysi reagent reaction upscal proceed high select without format boron ester product toler sensit function iodo bromo chloro fluoro nitro trifluoromethyl aminomethyl alkynyl amid zn oac hbpin combin also prove chemoselect cn reduct imin analog
|
D000447;D007659
|
T109
|
36,293,540
|
intern amyloid peptid inhibit store oper calcium entri ht cell dysregul calcium signal pathway play major role initi alzheim diseas ad pathogenesi accumul experiment evid obtain cellular anim model well ad brain sampl point high cytotox solubl small oligomer form amyloid peptid ad recent work propos calmodulin cam complex may play major role neuron ca signal mediat cam bind protein cambp stim recogn cambp play key role store oper calcium entri soce shown soce function diminish ad result instabl dendric spine enhanc amyloidogenesi work show h incub oligom immort mous hippocamp cell line ht lead intern nm nm respect intern oligom coloc endoplasm reticulum er co immunoprecipit stim unveil protein novel target fluoresc reson energi transfer measur stim tag green fluoresc protein gfp hilyt fluor show stim bind nanomolar concentr oligom site locat close cam bind site stim intern produc dysregul soce ht cell sustain alter cytosol ca homeostasi detect elicit h incub oligom conclud induc soce dysregul ht cell caus inhibitori modul stim partial activ er ca leak channel
|
D002118;D002147
|
T123;T196;T121;T116
|
36,293,539
|
physiolog patholog remodel cerebr microvessel grow evid remodel cerebr microvessel play import role plastic chang brain associ develop experi learn memori consolid time abnorm neoangiogenesi deregul regul microvascular regress prune could contribut pathogenesi neurodevelopment diseas stroke neurodegener aberr remodel microvesselsi associ blood brain barrier breakdown develop neuroinflamm inadequ microcircul activ brain region lead dysfunct neurovascular unit progress neurolog deficit review summar current data mechan blood vessel regress prune brain plastic alzheim type neurodegener discuss novel approach modul cerebr remodel prevent degener coupl aberr microvascular activ chronic neurodegener
|
D001812;D000544
|
T023;T048;T047
|
36,293,538
|
promot veget soybean gmtip respond divers abiot stress hormon signal transgen arabidopsi tonoplast intrins protein tip sub famili aquaporin aqp known play import role plant abiot stress respons howev evid promot tip involv abiot stress process remain scarc studi promot veget soybean gmtip gene highest similar tip type aqp plant clone express pattern analys indic gmtip gene dramat induc drought salt abscis acid aba methyl jasmon meja stimuli promot analys reveal gmtip promot contain drought aba meja cis act element histochem stain gmtip promot transgen arabidopsi corrobor strong express vascular bundl leav stem root beta glucuronidas gus activ assay show activ gmtip promot enhanc differ concentr polyethylen glycol peg nacl aba meja treatment integr result reveal gmtip promot could appli improv toler abiot stress transgen plant promot express veget soybean aqp
|
D017360;D020346;D007887
|
T123;T116;T002
|
36,293,537
|
magnet base human tissu cell cultur systemat review cell base assay conduct monolay cultur cell unquestion valuabl tool biomed research howev three dimension cell cultur model gain relev last year due advantag better mimick microenviron tissu microarchitectur vivo recent magnet base md cell cultur system use purpos system base expos magnet cell magnet field levit bioprint ring format promot cell aggreg structur howev success develop structur depend sever methodolog characterist appli mimic differ human tissu thus systemat review perform use medlin via pubm scopus web scienc februari databas aggreg studi use md cultur human tissu mimick search generat record met inclus criteria usabl md system develop homotyp heterotyp spheroid without scaffold explor studi also explor methodolog differ specif relat magnet method general develop md cultur increas bioprint levit system use generat homotyp heterotyp cultur main mimic physiolog human tissu also perform therapeut screen systemat review show area research applic method remain bare explor cancer research
|
D018874;D062028
|
T063;T025
|
36,293,536
|
macrophag phenotyp gene express pattern uniqu natur occur metabol healthi obes obes impact million individu global often co occur metabol syndrom though mani obes individu experi metabol abnorm metabol unhealthi obes muo metabol healthi obes mho convers gt lean individu metabol unhealthi mul evalu physiolog driver phenotyp anim african green monkey cohort select use metabol syndrom risk criteria repres four clinic defin health group bodi composit imag subcutan adipos tissu sq biopsi collect differ adipocyt size macrophag subtyp distribut gene express vascular fibrosi analyz use digit immunohistopatholog unbias rna seq endotheli cd masson trichrom stain respect mho demonstr signific increas macrophag p upregul fatti acid oxid relat term transcript includ fabp p muo demonstr downregul factor co occur upregul immun respons chang occur without differ distribut adipocyt size endotheli cell collagen deposit circul cytokin level without unhealthi diet consumpt healthi obes defin increas sq mm macrophag ratio lipid handl gene express highlight macrophag fatti acid oxid target improv metabol health obes
|
D000067329;D024821
|
T184;T047
|
36,293,535
|
isomelezitos overproduct algin entrap recombin e coli cell vitro evalu potenti prebiot effect work trisaccharid isomelezitos overproduc sucros use biocatalyst base immobil escherichia coli cell harbour glucosidas yeast metschnikowia reukaufii best nativ produc sugar describ date overal process isomelezitos product purif perform three simpl step oligosaccharid synthesi algin entrap e coli ii elimin monosaccharid glucos fructos use algin entrap komagataella phaffii cell iii semi prepar high perform liquid chromatographi isocrat condit result approxim g isomelezitos puriti exceed obtain g sucros potenti prebiot effect sugar probiot bacteria lactobacillus casei lactobacillus rhamnosus enterococcus faecium analys use vitro assay first time growth probiot bacteria cultur supplement isomelezitos signific improv similar cultur supplement commerci mixtur fructo oligosaccharid addit isomelezitos ad bacteria cultur product organ acid main butyr signific promot therefor result confirm isomelezitos potenti novel prebiot could includ healthier foodstuff design human gastrointestin balanc mainten
|
D056692;D019936
|
T007;T109
|
36,293,534
|
discoveri mitophagi inhibitor therapeut potenti differ famili amyotroph later sclerosi mutat mitophagi select degrad mitochondria autophagi promot turnov mitochondria prevent accumul dysfunct mitochondria lead cellular degener mitophagi known alter sever patholog condit especi neurodegen diseas amyotroph later sclerosi al recent demonstr increas autophagi flux lymphoblast al patient bear mutat sod thus identif mitophagi inhibitor may therapeut option recov mitochondri homeostasi use phenotyp mitophagi assay identifi new mitophagi inhibitor small molecul name ig mbc librari interest treatment differ cellular vivo model al mutat sod tardbp inhibitor restor autophagi control level result point mitophagi inhibitor especi ig new therapeut approach famili al patient
|
D063306;D000690
|
T047;T043
|
36,293,533
|
sax examin redox depend format dna sod complex cuzn superoxid dismutas sod play key role mainten cellular reactiv oxygen speci ros homeostasi antioxid enzym recent found sod involv regul gene express respons chang cellular ros level bind dna specif sequenc moreov sod bind dna observ redox depend solut thus examin redox depend dna bind sod multipl measur includ small angl x ray scatter sax indic redox depend format dna sod complex solut redox depend format dna sod complex could underli sod regul gene express
|
D000975;D013482
|
T123;T121;T116;T126;T039;T044
|
36,293,532
|
develop anti lrrc small fragment imag purpos use phage display scfv approach human leucin rich repeat contain protein lrrc membran protein identifi marker caf cancer associ fibroblast cell whose overexpress posit correl cancer grade outcom nuclear molecular imag ie spect pet track lrrc express could use guid therapeut strategi studi develop scfv mous phage display librari obtain small fragment antibodi human lrrc molecular imag purpos mice immun recombin human lrrc hlrrc lymph node cell harvest scfv singl chain variabl fragment phage display analysi built librari use pan cell line constitut induc express transfect choic best candid perform screen various cell line use flow cytometri select candid reformat cys scfv cys diabodi addit cystein clone mammalian express vector obtain batch small fragment use site specif radiolabel test obtain librari cfug insert rate gt two pan round perform cell permittedenrich screen flow cytometri allow us identifi specif hlrrc candid among two also recogn murin lrcc reformat cys scfv cys diabodi express transient mammalian system obtain mg cys fragment readi bioconjug radiolabel thus paper demonstr relev phage display scfv librari approach fast track develop small antibodi imag andor immunotherapi purpos
|
D057127;D001435
|
T129;T005
|
36,293,531
|
bis benzofuran n n heterocycl symmetr synthet drug lead yellow fever virus yellow fever virus yfv emerg rna virus caus larg outbreak africa central south america virus often transmit infect mosquito spread area area intern travel acut viral hemorrhag diseas yellow fever prevent effect safe reliabl vaccin elimin current antivir drug avail cure thus two seri novel bis benzofuran imidazolidin one bis benzofuran benzimidazol design synthes develop anti yfv lead candid among new bis conjug compound inhibit yfv strain stamaril huh cell cytopath effect reduct assay conjug exhibit compel efficaci select ec lt si gt result valuabl develop novel antivir drug lead emerg diseas
|
D000076742;D022341;D001572
|
T129;T121;T116;T109
|
36,293,530
|
cell adhes molecul affect ioniz radiat estrogen experiment breast cancer model cancer develop multi step process environment carcinogen exposur primari etiolog compon cell cell communic govern biolog activ tissu identifi molecular gene regul process essenti target metastat breast cancer ioniz radiat modifi damag dna rna cell membran compon lipid protein direct ionize compar differenti gene express help determin effect radiat estrogen cell adhes vitro experiment breast cancer model develop exposur immort human breast epitheli cell line mcf f low dose high linear energi transfer particl radiat subsequ growth presenc estradiol mcf f cell line analyz differ stage transform show gradual phenotyp chang includ alter morpholog increas cell prolifer relat control anchorag independ growth invas capabl becom tumorigen nude mice model use determin gene associ cell adhes communic e cadherin desmocollin gap junction protein alpha integrin alpha integrin beta keratin keratin keratin keratin b laminin beta result indic gene greater express tumorigen cell line tumor deriv athym anim alpha non tumorigen cell line expos radiat indic alter express level adhes molecul depend estrogen signific need experiment model system facilit studi cell plastic assess import estrogen modul biolog cancer cell
|
D001943
|
T191
|
36,293,529
|
reduct methyltransferas like mediat rna n methyladenosin exacerb develop psoriasi vulgari imiquimod induc psoriasi like mous model n methyladenosin methyl pervas intens studi mrna modif regul gene express differ physiolog process cell prolifer differenti inflamm studi aberr human diseas cancer obes infertil neuron disord immun diseas inflamm rapid evolv howev regulatori mechan physiolog signific methyl psoriasi vulgari still poor understood studi found methyl methyltransferas like mettl downregul psoriat skin lesion negat correl psoriasi area sever index pasi score inhibit methyl knock mettl promot develop psoriasi increas sever imiquimod induc psoriasi like model mice result indic critic role mettl mediat methyl pathogenesi psoriasi vulgari
|
D008780;D011565
|
T047;T126;T116
|
36,293,528
|
lipopolysaccharid lpss potent neurotox glycolipid alzheim diseas ad lipopolysaccharid lpss microbiom deriv glycolipid among potent pro inflammatori neurotoxin known homo sapien major sourc lpss gastrointestin gi tract resid facult anaerob gram negat bacilli includ bacteroid fragili escherichia coli lpss abund detect age human brain multipl independ research investig increas abund lpss around within alzheim diseas ad affect neuron found microbiom generat lpss endotoxin cross gi tract biophysiolog barrier system circul across blood brain barrier brain patholog process increas age vascular disord includ leaki gut syndrom evid indic lpss regul pro inflammatori transcript factor complex nf kb pp subsequ set nf kb sensit microrna includ mirna b mirna mirna mirna regul mirna turn regul famili neurodegener associ messeng rna mrna target includ mrna encod neuron specif neurofila light nf l chain protein nf l report regul peripher biofluid ad progress lethal pro inflammatori neurodegen disord nf l signific regul within neocort neuron may account neuron atrophi loss axon calib alter neuron cell shape modifi synapt architectur network deficit neuron signal capac paper review reveal current find neurotox aspect lpss pro inflammatori glycolipid contribut biolog mechan progress age relat ultim lethal neurodegen disord recent discov gut microbiota deriv lps nf kb mirna b nf l patholog signal network underscor direct posit patholog link lpss gi tract microb inflammatori neuropatholog disord cytoskeleton disrupt synapt signal ad brain stress human brain cell primari cultur ii first exampl microbiom deriv neurotox glycolipid signific detriment mirna mediat action express nf l abund filament protein known import mainten neuron synapt homeostasi
|
D000544;D035683;D019636;D020258
|
T123;T037;T114;T047;T048
|
36,293,527
|
effect angiogenesi base scaffold mesoporousbioact glass nanofib osteogenesi still urgent need effici biolog scaffold promot heal bone defect vessel acceler bone growth regener transport nutrient excel method joint increas osteogenesi angiogenesi bone regener therefor aim prepar composit scaffold could promot osteogenesi angiogenesi enhanc bone defect repair report scaffold prepar coaxial electrospin mesopor bioactiv glass modifi amino mbg nh adsorb insulin like growth factor igf core silk fibroin sf adsorb vascular endotheli growth factor vegf shell scaffold name mbg nh igf sfvegf might use repair materi promot bone defect repair interest found mbg nh igf sfvegf scaffold nano scale morpholog high poros well enough mechan strength support tissu moreov mbg nh could sustain releas igf achiev long term repair addit mbg nh igf sfvegf scaffold could signific promot mrna express level osteogen marker gene protein express level bmp runx bone marrow mesenchym stem cell bmscs meanwhil mbg nh igf sfvegf scaffold promot osteogenesi simul runx transcript activ phosphoryl erk activ pathway intrigu mbg nh igf sfvegf scaffold could also signific promot mrna express level angiogenesi marker gene protein express level cd furthermor rna sequenc verifi mbg nh igf sfvegf scaffold excel perform promot bone defect repair angiogenesi consist observ found mbg nh igf sfvegf scaffold demonstr good repair effect critic skull defect mice vivo promot format blood vessel haversian canal also acceler bone repair process conclud mbg nh igf sfvegf scaffold could promot bone defect repair acceler angiogenesi find provid new potenti biomateri bone tissu engin
|
D005349;D057139
|
T123;T116;T073
|
36,293,526
|
quantit proteom analysi reveal key molecular event drive phaeocysti globosa bloom dissip phaeocysti globosa marin bloom form haptophyt polymorph life cycl altern free live cell coloni morphotyp produc high biomass impact ecolog structur function mechan p globosa bloom format extens studi various environment factor believ trigger event howev littl known intrins biolog process drive bloom process mechan under p globosa bloom format remain enigmat investig p globosa bloom occur along chines coast compar proteom situ p globosa coloni bloom dissip phase use tandem mass tag tmt base quantit proteom approach among protein identifi protein display higher abund bloom dissip phase respect level protein involv photosynthesi pigment metabol nitrogen metabol matrix substrat biosynthesi distinct differ two phase ambient nitrat key trigger p globosa bloom format enhanc light harvest multipl inorgan carbon concentr mechan support prosper coloni bloom phase addit coloni bloom phase greater carbon fixat potenti carbon energi fix flow toward coloni matrix biosynthesi studi reveal key biolog process under p globosa bloom provid new insight mechan behind bloom format
|
D058087
|
T002;T204
|
36,293,525
|
upgrad monocyt therapi critic limb ischemia patient treatment pre clinic gmp valid aspect advanc cell therapi medicin product atmp forefront new rang biopharmaceut use atmp evolv increas last decad repres new approach treat diseas effect manag convent treatment standard worldwid recogn drug product good manufactur practic gmp wide use pharma product synthes drug appli also atmp gmp guidelin worldwid recogn standard manufactur medicin product guarante high qualiti safeti efficaci report describ pre clinic gmp upgrad peripher blood mononuclear cell pbmc prepar start peripher blood end gmp grade clinic product readi use patient critic limb ischemia cli also evalu product hypox condit increas pbmc function activ angiogen potenti furthermor extens analyz storag transport condit final product requir regulatori bodi atmp altogeth result suggest whole manufactur process perform clinic applic peripher blood collect physician transport room temperatur pbmcs isol clean room within h venipunctur frozen cell store nitrogen vapor thaw month pbmcs resuspend human albumin solut store transport c inject patient within h thaw hypox condit pbmcs implement clinic applic show signific enhanc pbmc function activ particular increas adhes migrat oxid stress resist demonstr feasibl qualiti gmp enrich suspens monocyt atmp test clean room facil aspect relat product respect gmp criteria allow use atmp think result could eas way clinic applic atmp
|
D001688;D000076742
|
T123;T121
|
36,293,524
|
integr analysi cytokin profil malaria patient disclos select upregul tgf il mild clinic present proper control plasmodium infect requir fine balanc immun respons evalu implic tgf tgf process use novel monoclon antibodi measur plasma concentr comparison cytokin express foxp mrna plasma cytokin level measur patient sever anaem malaria mild present use elisa rtpcr use measur foxp mrna express matur tgf isoform detect plasma latent tgf tgf strong upregul patient mild malaria near undetect patient sever diseas similar select upregul mild patient observ il foxp mrna il il il il although higher mild case also detect sever diseas contrast clear skew trend sever case toward higher pro inflammatori il il tnf th ifn respons observ associ higher level parasitaemia well lower igg higher igm respons togeth result suggest stimul regulatori cell tgf tgf il paramount effect balanc protect immun natur human malaria infect
|
D064094;D008288
|
T129;T047;T116
|
36,293,523
|
noninvas diagnost renal amyloidosi current state perspect amyloidos group diseas character accumul abnorm protein call amyloid differ organ tissu system amyloidos diseas relat increas level andor abnorm synthesi certain protein organ due patholog process eg monoclon gammopathi chronic inflamm rheumat arthriti treatment amyloidos focus reduc amyloidogen protein product inhibit aggreg therapeut approach critic depend type amyloidosi underlin import earli differenti diagnost fact accur diagnost amyloidosi type requir analysi biopsi specimen diseas affect organ howev absenc specif symptom amyloidosi invas natur biomateri sampl caus late diagnost diseas lead delay treatment signific reduc efficaci patient surviv establish noninvas diagnost method discoveri specif amyloidosi marker essenti diseas detect identif type earlier stage enabl time target treatment review focus current approach diagnost amyloidos primarili renal involv research perspect order design new specif test earli diagnosi
|
D000686;D000075363
|
T047;T191
|
36,293,522
|
autoimmun pancreat pathogenesi treatment autoimmun pancreat aip rare diseas diagnosi aip difficult made comprehens evalu clinic radiolog serolog patholog find two differ type aip identifi autoimmun pancreat type aip consid pancreat manifest multiorgan diseas relat igg autoimmun pancreat type aip consid pancrea specif diseas relat igg although pathophysiolog condit seem differ type type pancreat respond well steroid medic review focus pathogenesi diseas develop tool could facilit diagnosi lead discoveri new therapeut strategi combat autoimmun pancreat relaps standard therapi aip oral administr corticosteroid rituximab rtx also propos induct remiss mainten therapi relaps aip select patient immunomodul azathioprin use maintain remiss strength review compar previous studi focus clear differ two type autoimmun pancreat clear delin separ pathogenesi addit review also consid various therapeut option includ biolog drug anti tumor necrosi factor tnf therapi well toler effect second line therapi aip type relaps steroid depend biolog therapi also explor could provid use therapeut altern corticosteroid immunosuppress poor toler due signific side effect
|
D000081012;D001327;D001688
|
T123;T047;T121
|
36,293,521
|
studi sirna deliveri via polymer nanoparticl combin angiogenesi inhibitor treatment afp relat liver cancer angiogenesi inhibitor drug explor import pharmacolog agent cancer therapi includ hepatocellular carcinoma agent sever drawback drug resist nonspecif toxic system side effect therefor combin therapi drug small interf rna could promis option achiev high therapeut efficaci allow lower system dose therefor studi ad alpha fetoprotein sirna afp sirna incorpor polymer nanoparticl nps along angiogenesi inhibitor drug afp sirna load nps success synthes averag size nm combin treatment afp sirna nps low dose sunitinib produc synergist effect decreas cell viabil vitro hepatocellular carcinoma hcc model afp sirna nps togeth sorafenib sunitinib great inhibit cell prolifer show cell viabil respect moreov quantit revers transcript pcr qrt pcr demonstr afp sirna incorpor nps could signific silenc afp mrna express compar unload nps interest express level afp mrna decreas sunitinib ad therefor find consid new promis candid hcc treatment reduc cell prolifer enhanc therapeut outcom
|
D008113;D006528;D053758
|
T191;T073
|
36,293,520
|
evalu thera low volum resuscit fluid model polytrauma traumat brain injuri tbi hemorrhag remain challeng treat auster condit develop therapeut mitig associ pathophysiolog critic meet treatment gap especi injuri associ high mortal possibl prevent thera evalu low volum resuscit fluid rat model tbi hemorrhag therapeut uniqu situat tbi hemorrhag intervent contain cocktail protein microvesicl secretom adipos deriv mesenchym stromal cell act repair regen mechan associ poli trauma efficaci determin h post injuri evalu blood chemistri inflammatori chemocytokin histolog diffus tensor imag blood chemistri indic reduc marker liver damag sham level level remain elev control salin resuscit fluid histolog support potenti protect effect kidney diffus tensor imag show injuri caus damag corpus callosum fimbria immunohistochemistri suggest may mitig astrocyt activ h togeth data suggest may serv potenti field deploy low volum resuscit therapeut
|
D009104;D000070642
|
T037
|
36,293,519
|
comprehens identif analys grf gene famili whole genom four juglandacea speci grf gene famili play import role plant growth develop regul involv plant hormon signal metabol howev juglandacea grf gene famili remain studi identifi grf gene j regia c illinoinensi j sigillata j mandshurica respect phylogeni show juglandacea famili grf divid two subfamili group non group select pressur analysi detect amino acid loci subject posit select pressur addit found duplic juglandacea famili grf gene segment duplic event total ortholog gene pair one paralog homolog gene pair identifi four juglandacea famili kak ratio homolog gene pair analyz kak valu less indic purifi select play import role evolut juglandacea famili grf gene codon bias gene grf famili juglandacea speci weak affect natur select pressur base mutat translat select play domin role mutat pressur codon usag final express analysi show grf gene play import role pecan embryo develop walnut male femal flower bud develop differ express pattern conclus studi serv rich genet resourc explor molecular mechan flower bud differenti embryo develop juglandacea addit first studi report grf gene famili juglandacea famili therefor studi provid guidanc futur compar function genom studi grf gene famili juglandacea speci
|
D029525
|
T002
|
36,293,518
|
role intestin microb chronic liver diseas recent avail upgrad mani emerg intestin microb sequenc technolog research intestin microb chang rapid varieti investig found intestin microb essenti immun system regul energi metabol homeostasi impact mani critic organ liver first organ travers intestin portal vein strong bidirect link liver intestin mani intestin factor intestin microb bacteri composit intestin bacteri metabolit deepli involv liver homeostasi intestin microbi dysbiosi increas intestin permeabl associ pathogenesi mani chronic liver diseas alcohol fatti liver diseas afld non alcohol fatti liver diseas nafld non alcohol steatohepat nash chronic hepat b chb chronic hepat c chc autoimmun liver diseas aih develop hepatocellular carcinoma hcc intestin permeabl dysbacteriosi often lead lipopolysaccharid lps metabolit enter serum toll like receptor activ liver induc exposur intestin liver mani small molecul pro inflammatori properti eventu result various liver diseas paper discuss current evid role various intestin microb differ chronic liver diseas well potenti new therapeut approach propos review antibiot probiot prebiot may improv liver diseas
|
D006528;D000069196;D008113;D008107;D065626;D019936
|
T007;T191;T033;T047;T001
|
36,293,517
|
transcriptom analysi develop grain wheat cultivar tam tam reveal cultivar specif regulatori network wheat flour end use qualiti tight link quantiti composit storag protein endosperm tam tam two popular cultivar grown southern us great plain signific differ protein content investig regulatori differ transcriptom data analyz develop grain earli mid fill stage mid fill stage tam preferenti upregul starch metabol relat pathway compar tam wherea amino acid metabol transport relat pathway repres tam element analys also indic higher n percentag tam mid fill stage explor regulatori variat weight correl gene network construct public avail rnaseq dataset identifi modul differenti regul tam tam potenti transcript factor tfs regul modul identifi use graphic least absolut shrinkag select oper glasso homolog osnf famili member known starch metabol relat function show higher connect tam multipl tfs high connect tam predict function associ aba respons grain result provid novel target breeder explor understand mechan regul grain develop
|
D014908;D010940
|
T168;T116;T002
|
36,293,516
|
treadmil exercis reduc neuroinflamm glial cell activ improv synapt transmiss prefront cortex tg ad mice physic exercis improv memori cognit physiolog age alzheim diseas ad mechan remain poor understood test hypothesi oligom accumul neuroinflamm glial cell activ may lead disrupt synapt transmiss prefront cortex tg ad mice result impair learn memori hand treadmil exercis could prevent pathogenesi exert neuroprotect effect use immunohistochemistri western blot enzym link immunosorb assay slice electrophysiolog analyz level gsk oligom dimer trimer pro inflammatori cytokin il il tnf phosphoryl crmp thr synapt current pyramid neuron prefront cortex show week treadmil exercis begin three month old mice led inhibit gsk kinas activ decreas level oligom pro inflammatori cytokin il il tnf phosphoryl crmp thr reduct microgli astrocyt activ improv excitatori inhibitori synapt transmiss pyramid neuron prefront cortex tg ad mice thus treadmil exercis reduc neuroinflamm glial cell activ improv synapt transmiss prefront cortex tg ad mice possibl relat inhibit gsk kinas activ
|
D000544;D018696
|
T121;T047;T169;T048
|
36,293,515
|
target therapi advanc urotheli cancer monoclon antibodi antibodi drug conjug metastat urotheli cancer associ poor prognosi still major caus cancer relat death scarc option effect treatment progress platinum base chemotherapi immunotherapi human epitheli growth factor receptor identifi new therapeut target medic oncolog howev despit encourag result breast gastric cancer clinic trial anti monoclon antibodi tyrosin kinas inhibitor shown limit efficaci strategi urotheli tumor notabl favor data recent shown antibodi drug conjug current emerg novel promis approach target therapi advanc urotheli cancer
|
D018796;D002295;D000074322;D001749
|
T129;T121;T191;T116
|
36,293,514
|
drug repurpos cystic fibrosi identif drug induc cftr independ fluid secret nasal organoid individu cystic fibrosi cf suffer sever respiratori diseas due genet defect cystic fibrosi transmembran conduct regul cftr gene impair airway epitheli ion fluid secret new cftr modul restor mutant cftr function recent approv larg group peopl cf pwcf pwcf benefit cftr modul restor epitheli fluid secret non cftr pathway might effect treatment pwcf develop medium throughput well screen assay use nasal cf airway epitheli organoid aim repurpos fda approv drug modul non cftr depend epitheli fluid secret fda approv drug librari identifi valid fda approv drug induc cftr independ fluid secret among hit sever camp mediat drug includ adrenerg agonist hit display effect chlorid conduct measur uss chamber fluid secret affect tmema demonstr knockout ko experi primari nasal epitheli cell altogeth result demonstr use primari nasal airway cell medium scale drug screen target valid high effici protocol generat crispr cas ko cell identif compound induc fluid secret cftr tmema indep manner
|
D019005;D003550
|
T123;T047;T116
|
36,293,513
|
non reproduc oral rotenon model parkinson diseas mice oral rotenon propos model parkinson diseas pd mice establish model lab studi complex behavior follow publish treatment regimen cbl mice receiv mgkg bodi weight rotenon daili via oral administr week motor function assess rotarod run immunofluoresc studi use analyz morpholog dopaminerg neuron express alpha synuclein syn inflammatori gliosi infiltr substantia nigra rotenon treat mice gain bodi weight treatment compar g vehicl treat mice howev robust manifest drug treatment suggest local gut damag rotenon treat mice deficit motor behavior loss sign degener dopaminerg neuron syn accumul mild microgliosi latter like indirect remot effect rotenon evok gut dysbiosi search explan model failur analyz rotenon plasma concentr via lc msms h administr last dose assess bioavail rotenon detect plasma lower limit quantif ngml nm show oral rotenon insuffici bioavail achiev sustain system drug level mice henc oral rotenon caus local gastrointestin toxic evid lack weight gain fail evok behavior biolog correl pd within week
|
D010300;D020734
|
T047;T050
|
36,293,512
|
inflamm pulmonari hypertens edema induc hypobar hypoxia exposur exposur high altitud generat decreas partial pressur oxygen trigger hypobar hypox condit condit produc pathophysiolog alter organ lung one princip respons hypoxia develop hypox pulmonari vasoconstrict hpv improv gas exchang howev hpv exacerb induc high altitud pulmonari hypertens haph anoth import ill hypobar hypoxia high altitud pulmonari edema hape occur acut exposur sever studi shown inflammatori process activ high altitud ill highlight import crosstalk hypoxia inflamm aim review determin inflammatori pathway involv hypobar hypoxia investig key role inflamm lung patholog haph hape summar differ anti inflammatori treatment approach high altitud ill conclus hape haph show increas inflammatori cell infiltr macrophag neutrophil cytokin level il tnf il chemokin level mcp cell adhes molecul level icam vcam anti inflammatori treatment decreas inflammatori compon mention seem promis mitig strategi treat lung patholog associ high altitud exposur
|
D006976;D011654;D030361;D000532
|
T047;T046
|
36,293,511
|
collagen v chain decreas papillari dermi earli system sclerosi new propos cutan fibrosi molecular structur cutan fibrosi one main featur system sclerosi ssc recent find correl abnorm collagen v col v deposit dermi skin thicken diseas activ ssc consid col v import regul collagen fibrillogenesi understand role col v first two year skin fibrosi ssc earli ssc help determin new target futur treatment studi analyz morpholog ultrastructur molecular featur v v chain express code gene cola cola collagen fibrillogenesi earli ssc skin biopsi obtain seven consecut treatment nave patient ssc relat fibrosi four healthi control data show increas v v chain express reticular dermi earli ssc patient howev immunofluoresc ultrastructur immunogold stain determin signific decreas express v chain along dermoepiderm junction papillari dermi earli ssc patient relat control vs p lt immunoblot confirm decreas express v chain cutan fibroblast earli ssc despit increas cola cola gene express contrast v chain overexpress small vessel vs p lt capillari vs p lt reticular dermi earli ssc patient furthermor colva sirna ssc cutan fibroblast result decreas v chain express result highlight intens decreas v chain along dermoepiderm junction suggest alter molecular histoarchitectur ssc papillari dermi possibl decreas express v homotrimer isoform could interfer thicken cutan fibrosi relat ssc
|
D020405;D012595
|
T047;T024
|
36,293,510
|
central nervous mechan stress promot cancer progress evid show stress promot occurr develop tumor recent year mani studi shown stress relat hormon peripher neurotransmitt promot prolifer surviv angiogenesi tumor cell impair bodi immun respons caus tumor cell escap surveil immun system howev percept stress occur central nervous system cns role central nervous system tumor progress still unclear under mechan review summar known stress relat cns network activ stress respons influenc cns tumor discuss avail adjuv treatment method cancer patient negat emot state anxieti depress
|
D009369
|
T191
|
36,293,509
|
inhibit viral rna depend rna polymeras nucleosid inhibitor illustr uniti divers mechan rna depend rna polymeras rdrp essenti replic express rna viral genom class virus compris larg number high pathogen agent infect essenti speci plant anim includ human infect often lead epidem pandem remain larg control due lack specif reliabl prevent therapeut regimen unmet medic need led explor new antivir target rdrp major one due fact obligatori need virus growth recent studi demonstr abil sever synthet nucleosid analog serv mimic correspond natur nucleosid mimic caus stallingtermin rdrp misincorpor prevent virus replic promot larg scale lethal mutat sever analog receiv clinic approv routin use therapi parallel molecular structur basi inhibitori interact rdrp elucid reveal tradit novel mechan includ delay chain termin effect review offer molecular commentari mechan along clinic implic base analys recent result facilit ration design structur base antivir drug
|
D012324;D009705
|
T121;T126;T116;T114
|
36,293,508
|
spark plasma sinter assist synthesi bi fe bi feo heterostructur enhanc photocatalyt activ remov antibiot bismuth ferrit base heterojunct composit consid promis visibl light respons photocatalyst narrow band gap structur howev synthet method report literatur usual time consum studi report facil quick prepar bismuth ferrit base composit hydrotherm method combin spark plasma sinter sps techniqu usual use high speed consolid powder result demonstr sps assist synthes sampl possess signific enhanc photoelectr photocatalyt perform specif sps sinter c min sps exhibit time enhanc photocurr densiti time enhanc tetracyclin hydrochlorid photodegrad activ unmodifi bismuth ferrit sampl possibl influenc factor sps photoelectr photocatalyt perform bismuth ferrit base composit discuss care studi provid feasibl method facil quick synthesi high activ bismuth ferrit base visibl light driven photocatalyst practic applic
|
D001729;D000900
|
T121;T196;T195
|
36,293,507
|
phytochem combin effect individu compon reduc stress signal rat hippocamp neuron microglia vitro age relat decrement central nervous system cns thought result increas suscept accumul effect free radic inflamm dysregul ca homeostasi affect numer signal pathway certain bioactiv phytochem exhibit potent anti inflammatori activ may mitig age relat cns decrement studi investig individu combin effect green tea catechin epigallocatechin gallat egcg curcumin turmer broccoli sprout contain isothiocyan sulforaphan inflamm dysregul ca homeostasi determin individu compound work synergist andor independ mechan rat hippocamp neuron high aggress prolifer immort hapi microgli cell pre treat week either individu compon combin induc ca buffer deficit dopamin da h inflamm use lipopolysaccharid lps ngml h respect egcg combin protect da induc deficit ca buffer cell recov recoveri time p lt addit egcg combin reduc stress mediat inflamm hapi rat microgli cell attenu lps induc nitrit releas induc nitrous oxid synthas ino express tumor necrosi factor alpha tnf releas p lt cyclooxygenas cox express overal broccoli sprout curcumin effect egcg combin research need determin dietari intervent varieti food contain compound found green tea turmer broccoli sprout play role reduc age relat cns inflamm microgli activ downstream signal pathway lead neuron dysfunct
|
D002392;D003474
|
T121;T130;T109
|
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