PMID
int64 35.7M
36.4M
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36,293,406
|
chemiluminesc combin organ photosensit beyond light penetr depth limit photodynam therapi photodynam therapi pdt promis noninvas medic technolog approv treatment varieti diseas includ bacteri fungal infect skin diseas sever type cancer recent decad mani photosensit develop appli pdt howev pdt still limit light penetr depth although mani near infrar photosensit emerg chemiluminesc mediat pdt cl pdt system recent receiv attent requir extern light sourc achiev target pdt review focus ration design organ cl pdt system specif pdt type light wavelength chemiluminesc concept principl design cl pdt system introduc furthermor chemiluminesc fraction exampl strategi combin chemiluminesc pdt current cellular anim applic highlight final current challeng possibl solut cl pdt system discuss
|
D010778;D009369
|
T061;T191
|
36,293,405
|
develop method produc oxldl character effect hpv posit head neck cancer cell cardiovascular diseas cvd cancer two main caus death worldwid initi progress atherosclerosi larg part caus oxid low densiti lipoprotein oxldl interest oxldl may also play role cancer cell metabol migrat oxldl general obtain tedious ultracentrifug procedur home made oxldl obtain appli purif kit isol ldl vldl human plasma ii isol ldl vldl gel permeat chromatographi gpc iii oxid ldl cuso incub three hpv posit head neck cancer cell hncc vu um scc upci scc cell migrat assess use boyden chamber wnt catenin pathway analyz western blot express two oxldl receptor lox cd respons oxldl exposur analys immunofluoresc data indic non signific differ refer home made oxldl b decreas migrat parallel inhibit catenin pathway c increas cd lox express hncc conclus success produc oxldl result demonstr decreas hncc migrat oxldl exposur increas express lox cd associ lipid uptak
|
D030361;D006258
|
T047;T191
|
36,293,404
|
advanc genet studi powderi mildew resist tgr cucurbit powderi mildew cpm one main limit factor melon cultiv worldwid resist race report african access tgr whose resist control domin recess epistasi domin recess quantit trail loci qtl previous locat chromosom respect use sever dens genotyp bc famili deriv cross tgr suscept cultivar bola de oro fine map resist region phenotyp genotyp select bc bc bc bc bc xps bc xps offspr allow narrow candid interv kb region chromosom respect moreov temperatur effect resist provid domin gene confirm high resolut melt marker hrm tight link resist region use marker assist select program candid r gene variant parent caus potenti modifi impact protein function identifi within interv candid gene provid target futur function analys better understand resist powderi mildew melon
|
D001203
|
T004
|
36,293,403
|
human papillomavirus e apoptosi induc protein cancer treatment systemat review human papillomavirus type hpv well known etiolog factor cervic oropharyng cancer e protein product earli transcrib gene hpv postul caus death cancer cell via p depend p independ pathway main aim present systemat review studi hpv e protein apoptosi induc agent thorough search medlinepubm scienc direct scopus ebscohost databas conduct relev studi hpv apoptosi cell death hpv e involv search identifi public eleven record date januari februari found meet inclus criteria elig data extract inclus studi conclud hpv e abl induc cell death transfect cell e protein high risk hpv abl induc apoptosi differ apoptot pathway depend locat express gene howev mechan still unclear studi warrant
|
D009856;D030361;D009959;D002583
|
T123;T047;T191;T116
|
36,293,402
|
transcriptom metabolom analysi color chang fruit develop pepper capsicum baccatum fruit color one critic characterist pepper studi pepper capsicum baccatum l fruit four tran color period use experiment materi explor color convers mechan pepper fruit transcriptom metabolom analysi identifi total flavonoid metabolit carotenoid metabolit deg associ flavonoid biosynthesi deg relat carotenoid biosynthesi wgcna weight gene co express network analysi analysi posit correl modul flavonoid carotenoid identifi hub gene associ flavonoid carotenoid synthesi transport anticip identifi pinobanksin naringenin chalcon naringenin key metabolit flavonoid biosynthet pathway catalyz key gene chalcon synthas chs cqw cqw cqw cinnam acid hydroxylas ch cqw cqw cytochrom p cyp cqw cqw addit phytoen synthas psi cqw phytoen dehydrogenas pds cqw zeta caroten desaturas zds cqw lycopen beta cyclas lyc cqw zeaxanthin epoxidas zep cqw cis epoxycarotenoid dioxygenas nced cqw capsanthincapsorubin synthas ccs cqw key gene carotenoid biosynthet pathway catalyz synthesi key metabolit phytoen lycopen caroten caroten also found transcript factor famili p nbarc could play import role biosynthesi flavonoid carotenoid pepper fruit result provid new insight interact mechan gene metabolit involv biosynthesi flavonoid carotenoid pepper fruit lead color chang pepper fruit
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D002212
|
T168;T002
|
36,293,401
|
singl cell transcriptom wet amd patient deriv endotheli cell angiogen sprout age relat macular degener amd global lead caus visual impair older popul wet amd common subtyp diseas occur patholog angiogenesi infiltr subretin space choroid neovascular caus hemorrhag retin damag gold standard anti vascular endotheli growth factor vegf treatment effect therapi long term prevent visual declin success warrant need elucid potenti vegf independ pathway generat blood growth endotheli cell boec wet amd normal control subject induc angiogen sprout boec use fibrin gel bead assay deconvolut endotheli heterogen perform singl cell transcriptom analysi sprout boec reveal spectrum cell state wet amd boec share common pathway choroid neovascular extracellular matrix remodel promot proangiogen phenotyp activ boec subpopul demonstr proinflammatori hallmark resembl tip like cell vivo uncov new molecular insight patholog angiogenesi wet amd boec could also driven interleukin signal amino acid metabol web base visual sprout boec singl cell transcriptom creat facilit discoveri research
|
D020256;D057135
|
T047;T046
|
36,293,400
|
zearalenon induc mechan damag intestin barrier via rhoarock signal pathway ipec j cell zearalenon zen widespread contamin cereal agricultur product caus food safeti issu ingest food feed contamin zen disrupt intestin epitheli barrier function rhoarock signal pathway play key role regul epitheli barrier function studi role rare focus intestin aim experi investig exact mechan zen induc intestin barrier damag whether rhoarock signal pathway involv result show zen signific induc alkalin phosphatas ap activ fitc dextran kda passag across epitheli barrier signific reduc transepitheli resist teer meanwhil zen could induc signific regul mrna express tight junction protein occludin claudin zo claudin redistribut zo immunofluoresc studi demonstr zen exposur activ rhoarock signal pathway signific regul mrna express rock main effector signal pathway protein express phosphoryl myosin light chain mlc myosin light chain kinas mlck relat increas activ atp cell simultan remodel cytoskeleton f actin overal studi indic zen induc intestin barrier dysfunct activ rhoarock signal pathway
|
D009219;D015025
|
T131;T126;T116;T109
|
36,293,399
|
platelet deriv exosom atherosclerosi atherosclerosi main caus mani cardiovascular diseas cvds progress inflammatori diseas character accumul lipid fibrous element calcif innermost layer arteri result thicken clog vessel wall sever cell type direct involv patholog progress among platelet repres link inflamm thrombosi inde besid pivot role hemostasi thrombosi platelet key mediat inflamm injuri site act regul function blood vascular cell type includ endotheli cell ec leukocyt vascular smooth muscl cell vsmcs recent year increas evid point central role platelet deriv extracellular vesicl p ev modul pathogenesi howev role platelet deriv microparticl p mps signific investig recent year said platelet deriv exosom p exo reason review aim summar isol method biolog characterist p exo discuss involv intercellular communic pathogenesi evid show p exo cargo use biomark also present review
|
D055354;D055252;D050197;D013927
|
T026;T047;T046
|
36,293,398
|
individu variabl adipos stem cell prolifer gene express respons lipopolysaccharid stimul adipos stem cell asc report play role normal physiolog well inflamm diseas object work elucid inter individu differ growth gene express respons inflammatori stimuli asc differ donor human asc male donor asc femal donor purchas lonza walkersvill md cell prolifer determin sulforhodamin b assay time depend treatment asc without bacteri lipopolysaccharid lps marker gene mrnas prolifer steroid hormon xenobiot immun pathway determin use rt pcr secret cytokin level media measur use bio plex cytokin assay kit asc donor express androgen receptor estrogen receptor asc fold higher prolifer rate fold higher level prolifer marker ki mrna asc asc exhibit signific greater fold induct tnf ccl lps compar asc tnf gm csf protein level also signific higher lps induc asc media il secret higher lps induc asc media find suggest inter individu variabl andor possibl sex differ exist asc may serv key determin inflammatori respons asc
|
D008070;D016178
|
T129;T116;T109
|
36,293,397
|
kidney cyst line epitheli cell resist low dose cisplatin induc dna damag preclin model autosom domin polycyst kidney diseas increas dna damag respons ddr signal kidney cyst line epitheli cell cec may provid opportun cell specif therapeut target autosom domin polycyst kidney diseas adpkd hypothes inhibit ataxia telangiectasia mutat atm proxim ddr kinas togeth low dose cisplatin overwhelm ddr respons lead select apoptosi cyst line epitheli cell cec pkdrcrcatm mice treat either vehicl singl low dose cisplatin acut effect cec dna damag apoptosi h chronic effect progress cyst size inflamm fibrosi week investig h cisplatin caus dose depend increas hax posit nuclei cec non cystic tubul caus select apoptosi pkdrcrcatm mice moreov increas hax posit nuclei fold lower cec compar non cystic epitheli cell p lt low dose cisplatin also alter long term diseas progress pkdrcrcatm mice vitro human adpkd cyst deriv cell line also resist cisplatin wt wt cell viabil compar hk cyst growth mdck cell alter final combin low dose cisplatin azd atm inhibitor non select reduc hax cystic non cystic tubular cell exacerb cystic kidney diseas conclus data suggest cec resist dna damag combin cisplatin atm inhibitor effect strategi select elimin kidney cyst adpkd
|
D016891;D003560
|
T019;T047;T190
|
36,293,396
|
role tunnel nanotub nervous system cellular communic transfer inform one cell anoth crucial cell viabil homeostasi last decad tunnel nanotub tnts attract scientif attent mean direct intercellular communic also possibl system transport biolog cargo distant cell peculiar tnt characterist make abl increas cellular surviv capac well potenti target neurodegen diseas progress despit tnt format document number cell type exact mechan trigger format still complet known review summar highlight studi focus tnt format nervous system well role neurodegen diseas moreov aim stress possibl mechan import protein probabl involv tnt format nervous system
|
D019636;D043942
|
T047;T073
|
36,293,395
|
potenti antifung target aspergillus sp calcineurin heat shock protein pathway aspergillus speci especi fumigatus lesser extent other flavus niger terreus although rare pathogen healthi human aggress immunocompromis patient opportunist pathogen although surviv rate infect improv recent decad follow introduct azol deriv remain clinic challeng fact current antifung act fungistat rather fungicid limit safeti resist becom increas common make need new effect safer therapi becom acut last decad knowledg molecular biolog fumigatus aspergillus speci particular calcineurin hsp signal pathway protein progress remark although calcineurin attract much interest advers effect particular immunosuppress effect make less attract might first appear situat differ hsp protein signal pathway protein kinas phosphoryl four sprr serin residu crza rcna pmca pmcc particular pmcc rfef bar adapt protein phkb histidin kinas sskb map kinas kinas zfpa htfa ctfa swoh nucleosid diphosph kinas ccha mida fkbp k lysin posit hsp pkca mpka rlma brla abaa weta heat shock protein hsp hsp hsp current appear promis deserv investig potenti target antifung drug develop
|
D005659;D009701
|
T131;T126;T116
|
36,293,394
|
gpi anchor protein thi cd promot wound heal upon injuri skin enhanc skin perfus wound heal high regul multi step process involv plethora signal blood perfus crucial wound heal abnorm format new blood vessel defin outcom wound heal process thi implic angiogenesi silenc thi gene retard wound heal process howev role thi blood perfus wound closur remain unclear propos thi regul vascular perfus affect heal rate mous skin analyz time recoveri blood perfus use laser speckl contrast imag tissu morpholog imag acquir nanozoom tissu scanner latter assess tissu sampl taken biopsi punch sever day wound heal process result obtain thi knockout thi mice compar control mice thi mice show day seven delay epitheli increas micro macro circul ratio lower blood perfus wound area addit skin morpholog display flatter epidermi fewer ridg almost stratum granulosum corneum dermi thicker show fibroblast fewer lymphocyt result suggest critic role thi wound heal particular vascular dynam
|
D012867;D014945
|
T022;T040
|
36,293,393
|
physiolog transcriptom analys reveal effect elev root zone co metabol sugar starch root orient melon seedl root zone co major factor affect crop growth develop nutrient uptak metabol orient melon affect root zone gase growth microstructur sugar starch content enzymat activ relat sugar starch metabol gene express root orient melon seedl investig three root zone co concentr ck elev root zone co alter cellular microstructur acceler accumul releas starch grain disrupt organell format acceler root senesc sugar starch content metabol activ root increas within short durat follow treatment compar control differenti express gene deg identifi th day treatment plant respect deg enrich three metabol pathway major gene relat sucros starch hydrolysi upregul gene relat sucros metabol downregul studi reveal orient melon seedl adapt elev root zone co stress adjust sugar starch metabol transcriptom level provid new insight molecular mechan under respons elev root zone co stress
|
D036226;D028463
|
T168;T002
|
36,293,392
|
blood reflux induc epigenet factor hdac dnmts associ develop human chronic venous diseas blood reflux metabol regul play import role chronic venous diseas cvd develop histon deacetylas hdac dna methyltransferas dnmts serv repressor inhibit metabol signal induc proatherogen flow promot aortic endotheli cell ec dysfunct atherosclerosi aim studi elucid relationship blood reflux epigenet factor hdac dnmts cvd human varicos vein differ level blood reflux versus normal vein normal venous flow examin result show hdac overexpress endothelium varicos vein blood reflux blood reflux induc hdac enhanc varicos vein longer durat time blood reflux contrast hdac rare express endothelium normal vein normal venous flow similar result obtain dnmt dnmta find suggest epigenet factor hdac dnmts induc venous ec respons blood reflux inhibit respons normal venous flow blood reflux induc hdac dnmts could inhibit metabol regul promot venous ec dysfunct high correl cvd pathogenesi
|
D006655;D014648
|
T026;T047;T126;T116
|
36,293,391
|
ration mutagenesi lid domain ribokinas e coli result order magnitud increas activ toward arabinos develop effici approach product medic import nucleosid high relev challeng biotechnolog particular cascad synthesi arabinosid would allow relat easi product various cytostat antivir drug howev biocatalyst necessari approach ribokinas escherichia coli eco rk low activ toward arabinos make synthesi use state art nativ enzym technolog unfeas report result enzym design project dedic engin mutant form eco rk elev activ toward arabinos analysi activ site structur allow us hypothes reason behind low eco rk activ toward arabinos select feasibl mutat enzym assay kinet studi shown ag mutat caus larg fold increas k cat fold decreas k arabinos phosphoryl proof concept perform cascad synthesi chloroadenin arabinosid util ag mutant fold lower amount enzym compar wild type without loss synthesi effici result valuabl develop new technolog synthesi modifi nucleosid provid insight structur reason behind eco rk substrat specif
|
D001089;D054697
|
T121;T109
|
36,293,390
|
gut microbiota metabol disord breast cancer could berberin turn transvers nutraceut tool narrat analysi metabol disord main character mark alter lipid carbohydr profil addit clinic presenc direct consequ alter patholog condit consider increas preval recent year direct link onset various patholog includ cancer particular breast cancer hormon respons alongsid known condit respons scenario nutrit lifestyl general import colon microbiota various organ system becom increas evid fact evid microbi dysbiosi play fundament role onset metabol disord therefor condit indirect respons onset progress neoplasm indirect mechan alter firmicutesbacteroidet ratio format metabolit short chain fatti acid scfas particular butyr capabl act tumor suppressor glucuronidas activ estroboloma bacteria respons estrogen metabol import mechan contribut histori breast cancer therefor understand clinic term essenti associ modul metabol disord microbi condit contribut generat common therapi prefer use compound solut effect accept patient without side effect nutraceut berberin activ metabol scenario microbiota intervent modul microbi structur use probiot prebiot seem ideal solut prevent longer ignor strategi light numer data present literatur
|
D000069196;D001599;D001943;D008659
|
T121;T007;T109;T191;T047;T001
|
36,293,389
|
isol peptid inhibit sgc cell prolifer aspongopus chinensi dalla aspongopus chinensi dalla use tradit chines medicin well edibl insect although anti tumor effect observ anti tumor activ compon hemolymph chinensi remain unknown studi combin usag ultrafiltr gel filtrat chromatographi fplc rp hplc separ purifi activ peptid perform base prolifer human gastric cancer sgc cell line treat candid one peptid mw da isol hemolymph chinensi total amino acid residu continu determin activ peptid n ecgycaekgircddihcctglkkk c conclus peptid inhibit prolifer gastric cancer sgc cell hemolymph chinensi purifi studi homolog member spider toxin protein famili result facilit work peptid clone gene express vitro prokaryot eukaryot system specif test anti tumor activ
|
D013274;D020062;D013111
|
T123;T116;T131;T191;T204
|
36,293,388
|
lipid droplet lung cancer crucial cell growth starvat surviv rapid unlimit cell growth prolifer cancer cell requir larg quantiti nutrient mani metabol pathway nutrient uptak system frequent reprogram upregul meet demand cancer cell includ demand lipid lipid adult normal cell main acquir circulatori system whether differ cancer cell adopt ident mechan ensur suffici lipid suppli whether lipid demand suppli meet remain unclear investig lung cancer cell result show despit frequent upregul de novo lipogenesi lipid transport system differ lung cancer cell adopt differ protein acquir suffici lipid lipid suppli frequent exceed demand signific amount lipid store lipid droplet could found within lung cancer cell lipid droplet surfac protein plin found frequent overexpress sinc earli stage lung cancer tissu although express signific associ specif gender age histolog type diseas stage smoke habit frequent elev express plin protein indic import lipid droplet lung cancer lipid droplet nutrient storag also crucial tumor growth prolifer well surviv starvat result suggest manipul lipid droplet format tg storag lung cancer cell could potenti decreas progress lung cancer explor lipid biolog lung cancer could help design novel treatment strategi
|
D013217;D008175
|
T033;T191
|
36,293,387
|
sox promot invas human bladder cancer mmp upregul foxo downregul sox member sri relat hmg box sox famili abnorm express mani tumor associ cancer stem cell like properti previous report shown sox biomark cancer stem cell human bladder cancer bc recent studi indic inhibit sox anticanc compound chla f attenu human bc cell invas investig mechan sox promot invas abil bc cell studi reveal sox promot skp transcript increas skp acceler sp protein degrad sp transcript regul gene hur transcript therebi attenu absenc hur foxo mrna degrad fast promot bc cell invas addit sox promot bc invas upregul nucleolin transcript result increas mmp mrna stabil express collect find show sox promot bc invas skp sp hur foxo nucleolin mmp dual axe
|
D001749;D035683
|
T123;T191;T114
|
36,293,386
|
antimicrobi photoantimicrobi activ chitosancnppv nanocomposit multidrug resist bacteria repres global health econom burden urgent call new technolog combat bacteri antimicrobi resist develop novel nanocomposit ncps base chitosan display differ degre acetyl das conjug polym cyano substitut poli p phenylen vinylen cnppv altern approach inactiv gram negat e coli gram posit aureus bacteria chitosan structur confirm ft raman spectroscopi bactericid photobactericid activ ncps test dark blue light irradi condit respect hydrodynam size aqueous stabil determin dls zeta potenti zp time domain nmr tem micrograph ncps obtain capac generat reactiv oxygen speci ros blue illumin also character meaning variat zp relax time confirm success physic attach chitosancnppv ncps exhibit similar shrunken spheric shape accord tem lower da respons drive higher bactericid perform alongsid synergist effect cnppv lower nanos distribut profil higher posit charg surfac ros product proport found ncps without cnppv decreas da lead remark photobactericid effect blue light irradi overal find indic chitosancnppv ncps may constitut valuabl asset develop innov strategi inactiv andor photoinactiv bacteria
|
D048271;D053761
|
T121;T073;T109
|
36,293,385
|
use diamagnet coeffici estim reduc effect mass layer perovskit new insight high magnet field spectroscopi work current state research concern determin effect mass layer perovskit present avail experiment report reduc effect mass direct measur use magneto absorpt spectroscopi interband landau level review compar result dft comput studi various method conclud depend approach use found span broad rang valu low facilit quick reliabl estim model propos base sole avail experiment data bypass complex interband landau level spectroscopi model take advantag valu measur pea pbi approxim reduc effect mass given layer perovskit base two experiment paramet diamagnet coeffici effect dielectr constant propos model test broad rang layer perovskit captur well main experiment theoret trend
|
D060526
|
T070
|
36,293,384
|
impact placent slca defici first half gestat rumin placenta glucos uptak transfer mediat facilit glucos transport slca glut slca glut slca locat basolater trophoblast membran wherea slca locat sole matern face apic trophoblast membran slca less abund slca slca five fold greater affin transport capac base locat slca like play signific role uptak glucos trophoblast fetal hypoglycemia hallmark fetal growth restrict fgr defici slca could impact trophoblast glucos uptak transfer fetus thus potenti set stage fgr util vivo placenta specif lentivir mediat rna interfer rnai sheep abl signific diminish p placent slca concentr determin impact mid gestat dga respons slca rnai n fetus hypoglycem p exhibit reduc fetal growth includ reduc fetal pancrea weight p associ reduc umbil arteri insulin glucagon concentr compar non target sequenc nts rnai control n contrast fetal liver weight impact umbil arteri concentr igf possibl result increas p umbil vein chorion somatomammotropin csh concentr thus first half gestat defici slca result fetal hypoglycemia reduc fetal develop alter metabol hormon concentr result suggest slca may rate limit placent glucos transport first half gestat sheep
|
D007003;D061385
|
T121;T047
|
36,293,383
|
deodor garlic decreas oxid stress caus lipopolysaccharid rat heart hydrogen sulfid preliminari find deodor garlic dg may favor activ antioxid enzym promot synthesi hydrogen sulfid h object test dg favor increas h decreas oxid stress caus lipopolysaccharid lps rat heart total rat divid group group control c group lps group dg group lps plus dg cardiac mechan perform cmp coronari vascular resist cvr oxid stress marker total antioxid capac tac glutathion gsh selenium se lipid peroxid lpo thiol hydrogen sulfid h activ express thioredoxin reductas trxr glutathion peroxidas gpx glutathion transferas gst cystathionin synthetas cbs cystathionin lyas cth ino eno p analyz heart infarct zone cardiac tissu present p cmp cvr decreas increas p tac gsh h thiol gst activ p decreas lpo ino increas p activ express trxr gpx eno p cth cbs p decreas lps treatment howev dg normal effect dg treatment decreas heart damag caus lps cross talk h system
|
D006862;D005737;D012643
|
T123;T121;T131;T197;T168;T196;T130
|
36,293,382
|
mnhr function molt macrobrachium nipponens regul e synthesi mediat e signal hr member nuclear receptor famili extens studi insect molt develop report crustacean still lack current studi mnhr gene identifi macrobrachium nipponens improv molt molecular mechan nipponens studi investig whether mnhr function molt process nipponens domain phylogenet relationship structur mnhr analyz bioinformat quantit real time pcr qrt pcr analysi show mnhr high express ovari differ embryo stage highest mrna express observ cleavag stage cs differ individu stage mrna express mnhr reach peak fifteenth day hatch l vivo inject hydroxyecdyson e effect promot express mnhr gene silenc mnhr gene increas content e nipponens regulatori role mnhr e synthesi e signal investig rnai final function mnhr gene molt process nipponens studi count molt frequenc knock mnhr molt frequenc nipponens decreas signific prove mnhr play pivot role molt process nipponens
|
D018978;D033541
|
T040;T204
|
36,293,381
|
antifung effect nanoparticl covid link black fungus perspect biomed applic sever acut respiratori syndrom coronavirus sar cov high transmiss pathogen coronavirus caus coronavirus diseas covid pandem multipl wave threaten human health public safeti pandem patient covid acquir secondari infect mucormycosi also known black fungus diseas mucormycosi serious acut dead fungal infect caus mucoral relat fungal speci spread rapid henc prompt diagnosi treatment necessari avoid high mortal morbid rate major risk factor diseas includ uncontrol diabet mellitus immunosuppress also facilit increas mucormycosi infect extens use steroid prevent worsen covid lead black fungus infect general antifung agent dedic medic applic must biocompat non toxic easili solubl effici hypoallergen also provid long term protect fungal growth covid relat black fungus infect caus sever increas fatal therefor strong need develop novel effici antimicrobi agent recent nanoparticl contain product avail market use antimicrobi agent prevent bacteri growth littl known efficaci respect prevent fungal growth especi black fungus present review focus effect various type metal nanoparticl specif contain silver zinc oxid gold copper titanium magnet iron carbon growth various type fungi particular focus nanoparticl impact growth black fungus also discuss black fungus co infect context global covid outbreak manag guidelin help control covid associ black fungus infect final review aim elucid relationship covid mucormycosi
|
D000086382;D009091;D015034;D009090;D053758
|
T121;T073;T067;T197;T004;T047
|
36,293,380
|
deubiquitin enzym usp interact retin degener associ protein unca arl protein relat ubiquitin proteasom system play import role differenti ciliogenesi photoreceptor cell mutat sever gene involv ubiquitin proteostasi identifi causat inherit retin dystrophi ird ciliopathi usp deubiquitin enzym whose role retina still unexplor although previous studi indic relev neurosensori organ work describ pool endogen usp localis basal bodi retin cell provid data support function usp photoreceptor cilium also demonstr usp interact ird associ protein arl unca stabilis protein level use differ mechan result suggest usp may act regulationstabilis key ciliari protein photoreceptor function modul intracellular protein transport ciliari traffick photoreceptor outer segment
|
D046988;D058499
|
T047;T126;T116
|
36,293,379
|
advanc manag central nervous system metastas breast cancer central nervous system cns metastas common breast cancer bc patient particular relev new treatment bc prolong surviv review advanc treatment cns metastas bc includ radiotherapi system therapi evolv role immunotherapi use radiotherapi chemotherapi cornerston treatment cns metastas howev new target therapi recent develop includ anti agent antibodi drug conjug present promis result treatment patient
|
D001943;D016543;D016609;D018796;D001932
|
T121;T129;T191
|
36,293,378
|
reactiv centr loop mutagenesi serpinb target tmprss furin inhibit sar cov cell entri replic sar cov virus util host cell proteas facilit cell entri wherebi spike protein cleav two specif site enabl membran fusion furin transmembran proteas serin tmprss cathepsin l catl major proteas implic thus target anti viral therapi human serpin serin proteas inhibitor alpha antitrypsin aat show inhibitori activ tmprss previous found suppress cell infect sar cov generat modifi serpin inhibitor increas specif cellular proteas use serpinb scca cross class inhibitor catl scaffold design produc reactiv centr loop rcl variant specif target furin tmprss two variant generat substitut rcl p p spike protein ss cleavag site either sar cov alpha delta pr sequenc alter inhibitori specif purifi recombin protein verifi proteas assay attenu catl inhibit gain furin tmprss inhibit predict modifi serpin shown block protein cleavag vitro furthermor serpin variant abl inhibit pseudoparticl entri ace tmprss cell suppress sar cov replic vero e cell express tmprss construct design inhibit tmprss b tmp potent effect aat tmprss enzym inhibit eighteen fold improv second order inhibit rate constant block sar cov viral replic find advanc potenti serpin rcl mutagenesi generat new inhibitor may lead novel anti viral biolog molecul
|
D015843;D000086382
|
T123;T121;T116;T067;T047
|
36,293,377
|
global proteom profil aluminum induc hippocamp impair rat low dose aluminum realli safe hippocampus brain area aluminum al accumul abund wide associ learn memori present studi evalu behavior tissu proteom chang hippocampus wistar rat caus exposur dose mimic human consumpt aluminum chlorid alcl urban area male wistar rat divid two group control distil water alcl mgkgday group expos oral day al exposur protocol cognit function assess water maze test follow collect analysi global proteom profil hippocampus mass spectrometri asid proteom analysi perform histolog analysi hippocampus determin cell bodi densiti cresyl violet stain cornu ammoni field ca hilus region result indic exposur low dose aluminum chlorid trigger decreas cognit perform learn memori associ deregul protein express main relat regul cytoskeleton cellular metabol mitochondri activ redox regul nervous system regul synapt signal reduc cell bodi densiti ca ca hilus
|
D000535;D040901
|
T121;T196;T091
|
36,293,376
|
annexin improv osteogen differenti mesenchym stem cell expos high glucos condit lessen senesc osteoporosi frequent found chronic diabet patient result increas risk bone fractur occur under mechan osteoporosi diabet patient still larg unknown annexin anxa famili calcium bind protein report involv mani biolog process includ bone remodel studi aim investig role anxa mesenchym stem cell mscs vitro osteoinduct high glucos concentr osteogen gene express calcium deposit cellular senesc determin high glucos condit reduc osteogen differenti potenti mscs along lower express anxa moreov high glucos condit increas cellular senesc mscs determin senesc associ galactosidas stain express p p p gene addit recombin anxa could recov glucos induc deterior osteogen differenti mscs amelior glucos induc cellular senesc mscs western blot analysi reveal increas p phosphoryl p ser decreas recombin anxa msc osteoblast differenti high glucos condit studi suggest alter anxa high glucos condit may one plausibl factor deterior bone diabet patient trigger cellular senesc
|
D017306;D059630;D010024
|
T123;T047;T116;T025
|
36,293,375
|
identif investig genet variat candid gene respons seed weight via gwas paper mulberri seed direct determin surviv popul size woodi plant genet basi seed weight woodi plant remain poor explor identifi genet variat candid gene respons seed weight natur woodi popul investig hundr seed weight paper mulberri individu differ area result show hundr seed weight paper mulberri signific associ bioclimat variabl sampl site increas south north along latitudin temperatur gradient use high qualiti snps sequenc data genom wide associ analysi hundr seed weight perform three model identifi associ gene respect among candid gene direct hit signific snps includ wrki transcript factor fatti acid desaturas f box protein etc import identifi three crucial genet variat code region candid gene bpg bpg bpg signific differ hundr seed weight detect among individu carri differ genotyp analysi reveal bpg encod fatti acid desaturas fad might key factor affect seed weight local climat adapt woodi plant furthermor genom wide investig express analysi fad gene perform result suggest bpfad wide express various tissu respond multipl phytohormon stress treatment overal studi identifi valuabl genet variat candid gene provid better understand genet basi seed weight woodi plant
|
D031625;D044783
|
T116;T002
|
36,293,374
|
assess evalu scope constraint idylla molecular assay use differ sourc materi routin diagnost set cancer treatment diagnost concern tumor type determin molecular marker short tat critic fulli autom real time pcr base molecular diagnost idylla assay well establish mani laboratori qualit detect short tat routin screen clinic relev oncogen mutat accord manufactur ivd assay recommend use ffpe tissu sampl dissect least tumor content studi test perform accuraci ivd assay along gene fusion assay ruo differ tissuesourc materi like isol dnarna cryomateri etc studi also includ test archiv ffpe tissu section date back year perform check differ pan cancer sampl individu assay test ffpe section gdnarna input show accuraci sensit individu specif idylla assay also perform except well archiv ffpe tissu use assay solid tumor also remark perform test accuraci idylla assay show high effici certain limit use idylla assay qualit quantit applic differ tumor sourc materi could produc effici result differ diagnost set within short tat
|
D009369
|
T191
|
36,293,373
|
eraphla c kir genet profil coupl recurr implant failur proper embryo implant depend toler matern immun system fetus foreign patern antigen implant earli pregnanc domin leukocyt uterus uterin nk cell express killer immunoglobulin like receptor kir kir recogn human leukocyt antigen hla c human trophoblast inherit father mother antigen peptid present hla form via cleavag endoplasm reticulum aminopeptidas erap erap aim studi assess associ combin kir gene hla c ligand well erap erap polymorph recurr implant failur vitro fertil rif test coupl underw vitro fertil ivf fertil coupl genotyp cc rs erap femal male hla cc hla cc protect rif pp corr pp corr respect genotyp tt rs erap femal male hla cc genotyp increas risk rif summar combin femal erap hla c partner rs c gt rs c gt g polymorph play import role implant failur
|
D015236;D000076610
|
T129;T034;T116
|
36,293,372
|
thyroid hormon receptor knockdown reduc suppress progestin activ mtor pathway endometri cancer cell progestin resist major obstacl conserv therapi patient endometri cancer ec endometri atyp hyperplasia eah howev relat induc factor yet unclear studi thyroid hormon receptor tr tr patient assay thrb silenc rl kle ec cell cultur investig respons progestin transcriptom western blot perform investig chang signal pathway found thrb rather thra knockdown promot viabil motil rl cell kle cell suppress effect progestin cell growth motil signific decreas thrb silenc rl cell multipl prolifer relat signal pathway enrich activ mammalian target rapamycin mtor e bind protein ebp eukaryot translat initi factor g eifg rather phosphoryl protein kinas b akt remark boost progestin treatment enhanc effect augment partial abat supplement thrb knockdown kle cell progestin activ partial signal pathway express either mtor eifg supplement induc notic alter serum level triiodothyronin signific lower patient ec compar healthi women strong express tr observ patient ec eah sensit progestin treatment contrast tr posit express detect less half patient sensit progestin therapi conclus thrb knockdown enhanc viabil motil type ec cell attenu suppress effect progestin activ mtor ebpeifg pathway lower express thrb like correl progesteron resist
|
D011372;D016889
|
T125;T121;T039;T191
|
36,293,371
|
mulberri compon kuwanon c exert potent therapeut efficaci vitro covid block sar cov spike rbd ace receptor interact immens effort global pharmaceut compani develop anti covid drug includ small molecul base rna replic inhibitor via drug reposit antibodi base spike protein blocker relat cell entri sar cov howev sever limit clinic use emerg addit lack progress develop small molecul base cell entri inhibitor natur product studi test effect kuwanon c kc main research use silico dock simul serv effect build block develop anti covid drug block spike rbd ace receptor interact kc natur product deriv morus alba l common known mulberri known antivir efficaci molecular interact studi use competit elisa blitz system reveal kc target spike rbd ace receptor success disrupt interact support silico dock simul furthermor establish mechan action observ kc prevent infect sar cov spike pseudotyp virus acetprss overexpress hekt cell final demonstr kc inhibit clinic isol sar cov vero cell futur combin small molecul base cell entri inhibitor kc current prescrib rna replic inhibitor anticip signific enhanc efficaci covid therapi
|
D000086382;D031625;D001688
|
T121;T123;T067;T047;T002
|
36,293,370
|
updat innat immun acut kidney injuri lesson taken covid serious clinic cours sar cov infect usual accompani acut kidney injuri aki worsen prognosi increas mortal aki covid consequ system dysregul lead inflamm thrombosi vascular endotheli damag necrosi process reli interact innat immun element includ circul blood cell resid renal cell cytokin product complement system coagul cascad contact system numer simultan pathway innat immun secur effect host defens sinc form network cross link auto amplif loop uncontrol activ possibl action select pathway amplifi cascad activ evad control propag inflamm necrosi worsen accompani complement overact immunothrombosi system activ innat immun reach kidney damag affect singl tubular cell spread tissu collater damag trigger aki review attempt synthet connect innat immun compon engag covid relat aki summar knowledg pathophysiolog background process respons renal damag
|
D000086382;D058186
|
T047;T037;T067
|
36,293,369
|
characterist exosom vascular landscap regul exosom sequestr peripher tissu brain exosom mediat intercellular communic shuttl messag cell tissu explor whether exosom tissu sequestr determin exosom tissu use ten radiolabel exosom human murin cancer noncancer cell line measur sequestr exosom liver kidney spleen lung intraven inject male cd mice except kidney sequestr three exosom exosom incorpor tissu sequestr level vari great among exosom tissu speci origin mous vs human sourc cancer vs noncancer cell influenc tissu sequestr sequestr ja exosom liver involv mannos phosphat mp receptor wheatgerm agglutinin wga lipopolysaccharid lps treatment enhanc sequestr exosom brain lung inhibit sequestr liver spleen respons lps predict respons wga path heat map analys includ publish result brain found distinct cluster among exosom tissu conclus found evid univers bind site control exosom tissu interact instead sequestr exosom tissu differenti regul exosom tissu may stimul inhibit wga inflamm
|
D055354
|
T026
|
36,293,368
|
boadhbna effici uv maldi matrix high sensit auto tag glycom matrix select critic factor success glycom studi use matrix assist laser desorptionion mass spectrometri maldi ms studi evalu optim new solid ionic matrix benzylhydroxylamin boa dihydroxybenzo acid dhb na contain boa small amount sodium counter salt dhb concentr mixtur boadhbna glycan maldi target plate led benzyloxi tag reduc end glycan boadhbna matrix show excel aggreg perform abil form homogen solid salt maldi target plate water repel surfac addit boadhbna matrix show simpl peak pattern suppress sourc post sourc decay reduc end glycan well improv ionize effici glycan util characterist boadhbna matrix glycan analysi porcin stomach mucin show excel detect sensit reproduc peak pattern boadhbna matrix acceler glycom studi use maldi ms combin organ salt type matric develop constitut valuabl tool glycom studi
|
D054794;D011134
|
T090;T121;T109
|
36,293,367
|
revers platelet integrin iib activ thrombus instabl integrin iib activ essenti platelet aggreg accord hemostasi arteri thrombosi iib integrin high express platelet requir activ step bind fibrinogen fibrin von willebrand factor vwf current model assum process integrin activ reli actomyosin forc depend molecular chang bent close extend close extend open conform paper review pathway point function revers platelet iib activ transient aggreg furthermor refer mous model indic genet defect lead revers platelet aggreg also caus instabl thrombus format discuss platelet agonist signal pathway lead transient bind ligand integrin iib analysi point autocrin adp py py receptor signal via phosphoinositid kinas akt princip pathway link revers integrin activ downstream signal event protein kinas c caldag gefi rapb link transient integrin activ insight function revers integrin activ pathway help better understand effect antiplatelet agent
|
D019039;D013927
|
T129;T046;T116;T192
|
36,293,366
|
landscap genom alter pd l express earli stage non small cell lung cancer nsclc singl center retrospect observ studi precis oncolog immunotherapi revolution treatment advanc non small cell lung cancer nsclc emerg studi show target therapi also benefici patient driver alter epiderm growth factor receptor egfr mutat earli stage nsclc stage iiia furthermor patient elev program death ligand pd l express appear respond favor adjuv immunotherapi determin frequenc genom alter pd l status earli stage nsclc retrospect analyz data unselect singl center patient nsclc diagnos use next generat sequenc immunohistochemistri nine hundr sixti two patient present earli stage nsclc genom alter target therapi alreadi approv advanc nsclc frequenc driver mutat earli stage equival advanc stage ie rate egfr mutat adenocarcinoma earli advanc nsclc respect p addit earli stage nsclc case pd l posit tumor proport score tps compar frequenc driver mutat earli advanc nsclc pd l overexpress near half patient earli stage nsclc broad spectrum biomark adjuv neoadjuv therapi avail sever current investig clinic trial
|
D002289;D008175;D055752
|
T191
|
36,293,365
|
betula alba bark extract empetrum nigrum fruit juic natur altern niacinamid skin barrier benefit scandinavian region home uniqu biom endem plant speci aim studi explor natur divers identifi plant extract provid posit skin barrier effect six plant extract identifi start materi follow biochem screen two candid outperform rest betula alba ba empetrum nigrum en quantit pcr analysi show ba en upregul barrier gene use individu combin betula alba increas aqp ocln protein express someth niacinamid incap addit skin barrier strengthen evidenc inhibit klk hyaluronidas show strong antioxid anti inflammatori activ dpph cox inhibit respect first split face clinic studi conduct use combin extract versus placebo signific better skin restructur effect corneocyt cohes side treat combin extract second split face clinic studi assess combin extract versus niacinamid signific variat skin hydrat tewl observ favor extract treat side conclus identifi natur altern niacinamid improv skin barrier health scandinavian plant extract yield strong perform lower concentr
|
D029791;D024301
|
T002
|
36,293,364
|
methyl chh context allow predict recombin rice dna methyl studi epigenet trait consid key factor regul plant develop physiolog associ regul sever genom featur includ transposon silenc regul gene express recombin rate nonetheless understand relat dna methyl recombin rate remain challeng work explor associ recombin rate dna methyl two commerci rice varieti result show negat correl recombin rate methyl cytosin count context test time cg chg context independ contrast posit correl recombin rate methyl cytosin count report chh context similar behavior observ consid methyl cytosin within gene transposon retrotransposon moreov shown centromer region strong affect relationship recombin rate methyl final machin learn regress model appli predict recombin use count methyl cytosin chh context entranc featur find shed light understand recombin landscap rice repres refer framework futur studi rice breed genet epigenet
|
D012275
|
T168;T002
|
36,293,363
|
role notch signal pathway recoveri cardiac function myocardi infarct myocardi infarct mi patholog process evidenc massiv death cardiomyocyt associ hypox oxid stress format area fibrosi ultim lead heart failur mechan contribut function repair heart mammal includ human notch signal pathway cardioprotect effect involv format heart embryogenesi restor cardiac function mi due reduc oxid stress prevent apoptosi regul inflamm contain fibrosi hypertrophi cardiomyocyt tissu revascular regul prolifer differenti cardiomyocyt addit notch signal pathway interact signal cascad involv pathogenesi mi subsequ cardiac repair review consid notch signal pathway potenti target therapeut approach aim improv cardiac recoveri mi
|
D009203
|
T047
|
36,293,362
|
molecular dissect tdp lead caus alsftld tar dna bind protein tdp dnarna bind protein involv pivot cellular function especi rna metabol hyperphosphoryl ubiquitin tdp posit neuron cytoplasm inclus identifi brain spinal cord case amyotroph later sclerosi al substanti proport frontotempor lobar degener ftld case tdp dysfunct cytoplasm aggreg seem central pathogen al ftld therefor unravel physiolog patholog mechan tdp may enabl explor novel therapeut strategi review highlight current understand tdp biolog patholog describ cellular process involv pathogenes al ftld post translat modif rna metabol liquid liquid phase separ proteolysi potenti prion like propag propens tdp inclus
|
D057174;D000690;D057180;D011328
|
T047;T005;T116;T048
|
36,293,361
|
genet basi increas preval metabol syndrom among post traumat stress disord patient post traumat stress disord ptsd high debilit psychiatr disord trigger exposur extrem trauma even ptsd primarili psychiatr condit also character advers somat comorbid one ill common co occur ptsd metabol syndrom met defin set health riskresili factor includ obes elev blood pressur lower high densiti lipoprotein cholesterol higher low densiti lipoprotein cholesterol higher triglycerid higher fast blood glucos insulin resist phenotyp associ ptsd compon met test militari veteran cohort compris chronic ptsd present n case male consist previous observ found signific phenotyp correl various compon met ptsd sever score examin observ symptom correl stem share genet background conduct genet correl analysi use summari statist data larg scale genet studi result show robust posit genet correl ptsd met r g se p e obes relat compon met r g se p e priorit genom region larger local genet correl implic three signific loci overal find show signific genet overlap ptsd met may part account mark increas occurr met among ptsd patient
|
D013313;D024821
|
T047;T048
|
36,293,360
|
differ rna element control viral protein synthesi polerovirus isol evolv separ geograph region plant virus lack cap poli structur common host mrnas crucial translat initi thus altern translat initi mechan identifi viral mrnas one control rna element end abl enhanc mrna cap independ translat cite cite modular transfer rna element case polerovirus mechan translat initi rnas host cell still unclear thus studi one member cucurbit aphid born yellow virus cabyv determin effici cabyv rna translat requir presenc cite utr show cite requir presenc utr cis eif independ activ effici virus multipl depend cite activ cabyv isol belong three phylogenet group identifi far cite differ recombin predict analys suggest cite acquir recombin unknown donor sinc isol evolv differ geograph region may suggest respect cite possibl better adapt region propos translat polerovirus genom may also cite depend
|
D052679
|
T005
|
36,293,359
|
assess salt stress arabidopsi base detect hydrogen peroxid releas leav use electrochem sensor salt stress serious inhibitori effect various metabol process plant cell lead excess accumul reactiv oxygen speci ros hydrogen peroxid h type ros sever damag plant cell larg amount exist method assess content h releas leav salt stress caus irrevers damag plant leav unabl detect h product real time studi strength seri physiolog indic verifi occurr salt stress electrochem sensor detect h releas leav salt stress construct sensor prepar use multi wall carbon nanotub titanium carbid palladium mwcnt ti c x pd nanocomposit substrat materi show linear respons h detect rang mm detect limit moreov measur determin h releas arabidopsi leav differ time salt stress sensor consist convent method studi demonstr electrochem sens desir technolog dynam determin h releas leav assess salt stress plant
|
D017360;D037742
|
T104;T073;T002
|
36,293,358
|
target cxcr cd receptor overview new old molecul biolog person anticanc therapi biolog therapi multifacet applic revolution treatment tumor main due abil exclus target cancer cell reduc advers effect normal tissu review focus therapi target cxcr cd receptor survey result earli clinic trial test compound classifi nonpeptid small peptid cxcr antagonist specif antibodi whose activ reduc complet block intracellular signal pathway cell prolifer examin antibodi fusion protein cd receptor act eat signal phagocyt escap immun surveil despit molecul test earli clinic trial drawback emerg impair use practic final examin immunogen surrend mechan involv crosstalk co intern cxcr cd upon engag cxcr ligand molecul favor effect compound dual cd surfac reduct impact immun respons add block cxcr prolif potenti result suggest combin differ therapeut approach benefici effect patient surviv may pave way new accomplish person anticanc therapi
|
D051928;D009369
|
T129;T191;T116
|
36,293,357
|
third extracellular loop mammalian odor receptor involv ligand bind mammal recogn chemic air via g protein coupl odor receptor or addit orthoster bind site segment receptor modul ligand recognit focus human hora consid prototyp class ii or use combin molecular model site direct mutagenesi vitro function assay show third extracellular loop or ecl contribut ligand recognit receptor activ inde site direct mutat ecl show differenti effect potenc efficaci carvon citronellol nonanon
|
D018035
|
T116;T192
|
36,293,356
|
manufactur xeno feeder free clinic grade human embryon stem cell line first step cell therapi human embryon stem cell hesc increas use clinic trial chang outcom treatment mani human diseas use start materi differenti specif cell type achiev desir result cell therapi thus qualiti hesc taken account therefor current good manufactur practic cgmp implement transport embryo deriv inner cell mass xeno free feeder free defin hesc cultur cell freez depth character hesc line focus safeti pluripot differenti potenti genet background complement process paper show deriv three clinic grade hesc line mucg mucg mucg follow criteria develop valid system manufactur xeno free feeder free clinic grade hesc line present high qualiti start materi suitabl cell therapi accord cgmp
|
D000066449
|
T025
|
36,293,355
|
applic ftir spectroscopi detect chang skelet muscl composit due obes insulin resist stz induc diabet age obes diabet mellitus pathophysiolog interconnect factor signific contribut global burden non communic diseas metabol condit associ impair insulin function disrupt metabol carbohydr lipid protein lead structur function chang skelet muscl therefor alter macromolecular composit skelet muscl may provid indic under mechan insulin relat disord aim studi investig potenti fourier transform infrar ftir spectroscopi reveal chang macromolecular composit weight bear non weight bear muscl old obes insulin resist young streptozotocin stz induc diabet mice effici ftir spectroscopi evalu comparison result gold standard histochem techniqu differ biomolecular phenotyp alter muscl composit relat function properti observ ftir spectra suggest ftir spectroscopi detect chang observ muscl tissu histochem analys therefor could use effect altern allow complet character macromolecular composit singl relat simpl experi avoid obvious drawback histochem method
|
D007333;D003921
|
T046;T050
|
36,293,354
|
transgener toler salt osmot stress induc plant virus infect follow pathogen infect plant develop divers mechan direct immun system toward robust induct defens respons recurr environment stress induc resist could inherit progeni render toler stress event although within generat induct toler abiot stress well document phenomenon virus infect plant transgener inherit toler abiot stress progeni explor show infect nicotiana benthamiana plant potato virus x pvx chimer plum pox virus ppv express p pathogen protein pvx ppv p ppv confer toler salt osmot stress progeni correl level virul pathogen transgener toler abiot stress progeni partial sustain even plant experi virus free generat moreov progeni dicer like mutant mimick enhanc toler abiot stress observ progeni pvx infect wild type plant phenotyp shown irrespect whether dicer like parent infect suggest involv nt small interf rnas transgener toler abiot stress induc virus infect rnaseq analysi support upregul gene relat protein fold respons stress progeni pvx infect plant environment point view signific virus induc transgener toler abiot stress could question induct offset major reproduct cost aris detriment effect seed product
|
D017801;D017863
|
T005
|
36,293,353
|
genom wide associ express analysi lipoxygenas gene famili passiflora eduli reveal pelox might involv fruit ripe ester format aroma import factor fruit qualiti passiflora eduli passion fruit popular among consum rich flavor nutrit valu ester main compon volatil aroma passion fruit lipoxygenas lox first key enzym upstream ester may play import role format passion fruit aroma studi total passion fruit lox pelox member screen base passiflora eduli genom databas distribut uneven chromosom contain high conserv lipoxygenas domain contain plat domain gene structur evolutionari analysi cis act element famili member predict studi transcriptom analysi show pelox gene differ degre respons differ abiot stress drought stress salt stress cold stress high temperatur pelox pelox pelox pelox pelox respond signific various abiot stress pelox pelox littl chang express stress quantit real time pcr qrt pcr six tissu reveal pelox gene exhibit tissu express specif relat express gene particular high root stem fruit focus passion fruit ripen ester synthesi transcriptom analysi show increas fruit develop fruit matur express level pelox pelox pelox pelox show downregul express pelox pelox show upregul express particular upregul trend pelox obvious qrt pcr result consist transcriptom result pearson correl analysi show develop ripen fruit express level pelox lox enzym activ total ester content show increas trend particular period peel red shrank stage ester content increas time highest express level period result indic pelox may candid gene involv fruit ripe format volatil aroma compound increas fruit ripen express level pelox increas lox enzym activ increas accord therebi promot synthesi volatil ester fruit pulp discoveri lay foundat function studi lox passion fruit
|
D029598
|
T121;T168;T002;T109
|
36,293,352
|
intact type interferon receptor signal prevent hepatocellular necrosi enceph dose depend manner rift valley fever virus infect mice rift valley fever rvf zoonot emerg diseas caus rvf virus rvfv rumin lead abort storm enhanc mortal rate young anim wherea human caus symptom like sever hemorrhag fever enceph role innat adapt immun respons diseas initi progress still poor defin present studi use attenu rvfv strain clone investig viral spread tissu tropism histopatholog lesion intranas infect cbl wild type wt type interferon ifn receptor knockout ifnar mice wt mice pfu rvfv high dose result fatal enceph hepat day post infect dpi wherea pfu rvfv low dose caus clinic diseas signific histopatholog lesion liver central nervous system cns contrast ifnar mice infect pfu rvfv develop hepatocellular necrosi result death dpi lack enceph result show ifnar signal prevent system spread attenu rvfv strain clone dissemin cns subsequ fatal diseas consequ neurotrop virus may abl evad antivir ifn signal pathway use transneuron instead hematogen rout
|
D012296;D006528;D008113;D004660;D007370
|
T121;T129;T116;T191;T005;T047
|
36,293,351
|
molecular mechan divers auxin respons plant growth develop plant hormon auxin act signal molecul regul numer development process throughout stage plant growth understand auxin regul various physiolog development process hot topic intrigu field recent studi unveil molecular detail divers auxin respons function everi aspect plant growth develop review systemat summar classifi molecular mechan divers auxin respons comprehens elabor characterist multilevel regul mechan canon transcript auxin respons basi describ characterist differ differ auxin respons also present auxin respons gene genet modifi plant speci chang impact various trait interest final summar import aspect unsolv question auxin respons need focus address futur research review help gain overal understand insight divers molecular mechan auxin respons plant growth develop instrument har genet resourc molecular breed extant plant speci
|
D007210;D010937
|
T125;T123;T116;T109
|
36,293,350
|
molecular mechan mous uterin smooth muscl regul embryo implant myometrium play critic role multipl process embryo space peristalsi mous implant indic vital role smooth muscl success establish qualiti implant actin key element cytoskeleton structur play import role movement contract smooth muscl cell smcs howev function peri implant uterin smooth muscl regul mechan muscl tension still unclear studi focus molecular mechan actin assembl regul implant smooth muscl phalloidin high select bicycl peptid use stain actin filament also known f actin phalloidin stain show f actin gradual weaken cd mous myometrium day day earli pregnanc mice studi group jasplakinolid jasp use inhibit f actin depolymer promot f actin polymer smcs implant window consequ compromis embryo implant qualiti transcriptom analysi follow jasp treatment mous uterin smcs reveal signific molecular chang associ actin assembl tagln involv regul cell cytoskeleton promot polymer g actin f actin result show tagln express gradual reduc mous uterin myometrium day pregnanc furthermor progesteron inhibit express tagln progesteron receptor use sirna knock tagln day smcs found phalloidin stain decreas confirm critic role tagln f actin polymer conclus data suggest decreas actin assembl uterin smooth muscl earli pregnanc critic optim embryo implant tagln key molecul involv actin assembl regul embryo implant control f actin aggreg implant suggest moder uterin contractil conduc embryo implant studi provid new insight mous uterus increas flexibl accommod implant embryo earli stage pregnanc
|
D000199;D011980
|
T123;T116;T192
|
36,293,349
|
isomir eqtl cancer specif express quantit trait loci databas mirna isoform identif express quantit trait loci eqtl import compon effort understand genet variant influenc diseas risk microrna mirna short noncod rna molecul capabl regul express sever gene simultan recent sever novel isom mirna isomir differ slight length sequenc composit compar canon mirna report present isomir eqtl user friend databas design help research find singl nucleotid polymorph snps impact mirna mir eqtl isomir express isomir eqtl cancer type isomir eqtl includ total mir eqtl isomir eqtl fals discoveri rate fdr also includ mir eqtl overlap known cancer associ loci identifi genom wide associ studi gwas best knowledg first studi investig impact snps isomir express genom wide level databas may pave way research toward find model personalis medicin mirna isomir genotyp utilis
|
D035683;D009369
|
T123;T191;T114
|
36,293,348
|
mayo clinic florida microdosimetr kinet model clonogen surviv applic various repair compet rodent human cell line relat biolog effect rbe calcul use plan ion therapi treatment general base microdosimetr kinet model mkm local effect model lem mayo clinic florida mkm mcf mkm recent develop overcom limit previous mkms reproduc biolog data elimin need ion expos vitro data input model calcul sinc consid implement mcf mkm clinic articl present extens benchmark mcf mkm predict correspond vitro clonogen surviv data rodent cell line expos ion h u b systemat comparison publish result latest version lem lem iv addit introduc novel approach deriv approxim valu mcf mkm model paramet know anim speci mean number chromosom overal good agreement mcf mkm predict vitro data suggest mcf mkm reliabl use rbe calcul case reason agreement found mcf mkm lem iv
|
D012377
|
T015
|
36,293,347
|
electr stimul human adipos deriv mesenchym stem cell plasma treat ito glass promot osteogen differenti electr signal repres essenti form cellular communic decad electr stimul use effect clinic practic enhanc bone heal howev detail mechan electr stimul bone heal well understood addit mani difficulti set stabl effici electr stimul system within vitro environ therefor various conduct materi electr stimul method test establish effect electr stimul system system mani studi conduct effect electr stimul bone heal osteogen differenti howev previous studi limit use opaqu conduct materi obscur cell fluoresc observ stain known two critic method confirm state cell indium tin oxid ito glass known excel transpar conduct challeng cultiv cell due low cell adhes characterist therefor use plasma treatment increas hydrophil wettabl ito glass enhanc cell affin glass provid stabl surfac cell attach electr stimul appli amplitud rang frequenc hz result demonstr osteogen differenti effici maxim amplitud condit accord result studi suggest develop excel platform field biolog research good tool elucid various mechan cell bioactiv electr condit
|
D010012;D059630
|
T025;T042
|
36,293,346
|
respons urotheli carcinoma cell line cisplatin cisplatin cddp base chemotherapi standard care patient muscl invas bladder cancer howev larg number case diseas becom resist respond cddp thus progress dissemin case prognosi patient poor cddp manifest cytotox effect main dna damag induct henc respons cddp main depend dna damag repair toler mechan herein examin cddp respons panel urotheli carcinoma cell ucc line character cell line regard viabil cddp treatment well kinet induct repair cddp induc dna damag demonstr repair cddp induc dna lesion correl least extent cddp sensit furthermor monitor express key gene involv select dna repair toler mechan nucleotid excis repair homolog recombin transles dna synthesi show differ ucc line posit correl cddp resist data indic cddp respons ucc line depend dna damag repair toler factor may therefor repres valuabl therapeut target malign
|
D002295;D001749;D000970
|
T121;T191;T109
|
36,293,345
|
accuraci fib detect elev liver stiff measur patient non alcohol fatti liver diseas cross section studi referr center identif advanc fibrosi appli noninvas test still key compon diagnost algorithm nafld aim studi assess concord fib liver stiff measur lsm patient refer two liver center ultrasound base diagnosi nafld fibrosi index liver fibrosi fib lsm assess patient total lsm kpa wherea patient fib lt gt respect among patient fib lt lsm kpa fals negat fib proport higher patient year diabet mellitus dm arteri hypertens bodi mass index bmi kgm multipl adjust model age year odd ratio confid interv ci dm ci bodi mass index bmi kgm ci gamma glutamyltransferas uil ci associ fals negat fib proport fals negat fib patient none one risk factor increas among two three four concomit risk factor respect fib suboptim identifi patient refer liver center one fifth may fals negat fib instead lsm kpa
|
D065626
|
T047
|
36,293,344
|
tryptophan modulatori role european seabass dicentrarchus labrax immun respons acut inflamm stress condit present work aim studi role dietari tryptophan supplement modul european seabass dicentrarchus labrax immun condit stress rear condit ie day exposur high densiti well immun respons acut inflamm intraperiton inject bacteri pathogen stress alon compromis seabass health indic contrast clear peripher local inflammatori respons observ respons inocul bacteria moreov exposur high stock densiti seem exacerb inflammatori respons earli sampl point compar fish stock lower densiti contrast stress fish present immun suppress effect cell surfac glycoprotein receptor express late sampl point follow inflamm regard effect dietari tryptophan chang observ seabass immun indic prior inflamm small number immunosuppress effect observ respons inflamm support tryptophan role promot immun toler signal inflamm nonetheless tryptophan dietari supplement improv inflammatori respons bacteri pathogen stress condit support reduct plasma cortisol level regul sever immun relat gene h invers previous observ stress induc cell suppress final involv tryptophan catabol macrophag confirm regul gene involv kynurenin pathway present studi bring new insight regard immun modulatori role tryptophan stress condit fish thus allow develop novel prophylact protocol vaccin intraperiton inject european seabass
|
D001492
|
T013
|
36,293,343
|
import fawrki strawberri fragaria ananassa fruit ripen wrki transcript factor play nonneglig role plant growth develop littl known involv wrki transcript factor regul fruit ripen studi fawrki identifi close relat fruit matur octoploid strawberri fawrki protein local nucleus respond cold salt low phosphat aba light qualiti strawberri seedl tempor spatial pattern express analysi indic fawrki express detect tissu especi full red fruit addit fawrki gave rise accumul anthocyanin content promot express structur gene faf h falar faanr transport factor fatt fatt flavonoid pathway soften textur strawberri via regul abund fapg fapg furthermor fawrki posit regul mediat resist reactiv oxygen speci enhanc enzym activ sod pod cat reduc amount mda altogeth studi provid new comprehens insight regulatori mechan facilit fruit ripen strawberri
|
D031985
|
T168;T002
|
36,293,342
|
earli doxorubicin myocardi injuri inflammatori oxid stress apoptot role galectin doxorubicin doxo effect drug use treatment larg number cancer regardless import chemotherapeut characterist usag restrict serious side effect obvious cardiotox manifest acut year complet treatment lead left ventricular dysfunct dilat cardiomyopathi heart failur galectin gal beta galactosid bind lectin differ role normal pathophysiolog condit gal found upregul anim model correl heart failur atherosclerosi myocardi infarct male cbj bcg lgal lt tm poi gt j gal knockout ko mice use mous model acut doxo induc cardiotox mice given doxo vehicl normal salin mice free access food water heart plasma sampl collect day doxo administr use tissu process stain electron microscopi enzym link immunosorb assay elisa signific increas heart concentr gal gal wild type doxo treat mice compar sham control signific higher concentr heart cleav caspas plasma troponin plasma lactat dehydrogenas plasma creatin kinas gal ko doxo treat mice gal wild type doxo treat mice moreov signific higher heart antioxid protein lower oxid stress gal wild type doxo treat mice gal ko doxo treat mice conclus gal affect redox pathway regul cell surviv death myocardium follow acut doxo injuri
|
D037502;D006333
|
T129;T047;T046;T116
|
36,293,341
|
aphid bcr structur activ uncov new defensin peptid superfamili aphid hemiptera aphidoidea among detriment insect agricultur plant manag great challeng agronom research new class protein call bacteriocyt specif cystein rich bcr peptid provid altern chemic insecticid pest control bcrs initi identifi pea aphid acyrthosiphon pisum small disulfid bond rich protein express exclus aphid bacteriocyt insect cell host intracellular symbiot bacteria show one pisum bcrs bcr display promin insecticid activ pea aphid impair insect surviv nymphal growth provid evid potenti use new biopesticid compar genom phylogenet analys indic bcrs restrict aphid lineag structur bcr reveal peptid belong yet unknown structur class peptid defin new superfamili defensin
|
D001042;D007306
|
T131;T204
|
36,293,340
|
role cryoprotect agent liposom stabil preserv improv liposom usag drug deliveri vehicl cryoprotect util prevent constitu leakag liposom instabl cryoprotect agent cpas cryoprotect protect liposom mechan stress ice vitrifi specif temperatur form glassi matrix major studi cryoprotect demonstr concentr cryoprotect increas liposom stabil improv result decreas aggreg effect cpas maintain liposom stabil aqueous state essenti depend complex interact protect bilay composit furthermor differ type cpas distinct effect mechan action therefor combin sever cryoprotect may benefici novel attribut synergist action cpas review discuss use liposom drug deliveri vehicl phospholipid cpa interact thermotrop behavior freez type cpa mechan prevent leakag drug liposom
|
D003451;D008081
|
T121;T039;T109
|
36,293,339
|
insight carbapenem resist vibrio speci current status futur perspect increas preval resist carbapenem escal concern carbapenem reserv last line antibiot although indiscrimin antibiot usag consid primari caus resist develop increas evid reveal inconsequenti strain without direct clinic relev carbapenem usag harbor carbapenemas gene phenomenon indirect impli environment microbi popul could hidden vector propel carbapenem resist work aim explor carbapenem resist profil vibrio speci across divers set review proceed identifi differ factor contribut dissemin resist trait defin transmiss pathway carbapenem resist deciph mechan carbapenem resist acquisit could help design better prevent strategi curb progress antimicrobi resist develop better understand vast reservoir select carbapenem resist non clinic set vibrio speci also prospect one potenti indic strain carbapenem resist environ
|
D001618;D014733
|
T007;T126;T116
|
36,293,338
|
citrus flavonoid nobiletin downregul angiopoietin like protein angptl express exhibit lipid modul effect hepat cell adult zebrafish model nobiletin dietari citrus flavonoid exert biolog activ hyperlipidemia obes atherosclerot cardiovascular diseas ascvd aim studi explor lipid lower effect nobiletin under molecular mechan vitro hepat cell vivo zebrafish model transcriptom gene ontolog go analys differenti express gene deg gene set enrich analysi gsea show set twenti eight core enrich deg associ go bp regul lipid metabol process go signific downregul nobiletin treat cell among gene angiopoietin like angptl inhibitor lipoprotein lipas lpl activ regul tg rich lipoprotein tgrl metabol circul protein mark downregul nobiletin nobiletin signific reduc level angptl mrna intracellular secret angptl protein hepat cell line furthermor allevi secret angptl product nobiletin found reinstat lpl catalyt activ nobiletin signific inhibit angptl promot activ attenu transcript factor liver x receptor lxr mediat angptl transcript molecular dock analysi predict nobiletin could bind ligand bind domain lxr therebi counteract lxr activ anim studi oral administ nobiletin signific allevi level plasma triglycerid tgs cholesterol zebrafish fed high fat diet moreov nobiletin signific reduc amount hepat angptl protein zebrafish find suggest nobiletin may regul lxr angptl lpl axi exhibit lipid modul effect vitro vivo thus nobiletin potenti angptl inhibitor regul lipid metabol amelior dyslipidemia ascvd
|
D000091303;D002957
|
T123;T168;T116;T002
|
36,293,337
|
long term advers effect liver stiff glycaem control type diabet patient nonalcohol fatti liver diseas pilot studi current limit data regard long term effect liver stiff glycaem control patient type diabet mellitus tdm nonalcohol fatti liver diseas nafld prospect follow outpati sampl consecut postmenopaus women tdm nafld baselin data liver ultrasonographi fibroscan assess liver stiff measur lsm underw follow haemoglobin ac hbac measur baselin follow baselin patient nafld hepat steatosi alon nafld coexist clinic signific fibrosi defin lsm kpa fibroscan follow patient worsen glycaem control arbitrarili defin hbac increas baselin preval nafld coexist clinic signific fibrosi baselin least three time greater among patient develop wors glycaem control follow compar vs p logist regress analysi presenc nafld clinic signific fibrosi associ approxim fold increas likelihood develop wors glycaem control follow odd ratio confid interv p even adjust baselin confound factor age bodi mass index haemoglobin ac homa estim insulin resist use glucos lower agent may posit affect nafld liver fibrosi conclus result suggest presenc fibroscan assess signific fibrosi associ higher risk develop wors glycaem control postmenopaus women tdm nafld
|
D065626;D003924
|
T047
|
36,293,336
|
rapid remov toxic remazol brilliant blue r dye aqueous solut use juglan nigra shell biomass activ carbon potenti adsorb optim isotherm kinet thermodynam investig recent treatment effluent agricultur wast biomass signific attract wide interest among research due avail efficaci low cost remov toxic remazol brilliant blue r rbbr aqueous solut use hno treat juglan nigra walnut shell biomass carbon adsorb examin various experiment condit initi ph adsorb concentr adsorb dosag particl size agit speed type electrolyt experi design achiev maximum dye remov effici use respons surfac methodolog rsm optimum ph adsorb dosag particl size found g l respect maximum decolor effici prepar adsorb character particl size brunauer emmett teller bet surfac area pore volum zero point charg ph zpc fourier transform infrar spectroscopi ft ir field emiss scan electron microscopyenergi dispers x ray spectroscopi fe semedx x ray diffract xrd thermogravimetr analysi tga base fit experiment data various model isotherm kinet mechan found appropri langmuir isotherm pseudo second order kinet adsorpt mechan describ intra particl diffus model bangham boyd plot overal rate adsorpt control extern film diffus dye molecul maximum monolay adsorpt capac q max mg g rbbr dye obtain temperatur k thermodynam standpoint process endotherm spontan chemisorpt process favor high temperatur desorpt studi conduct various desorb reagent various run maximum desorpt effici third run obtain use solvent methanol reusabl studi demonstr prepar adsorb effect three run oper investig outcom conclud walnut shell biomass activ carbon wsbac cost effect eco friend bio sustain materi use synthet dye decolor aqueous media
|
D031324;D014874
|
T131;T002
|
36,293,335
|
molecular genet event determin soften fleshi fruit comprehens review fruit soften occur fruit ripen postharvest storag determin fruit qualiti shelf life commerci valu make fruit attract seed dispers addit soften result fruit eventu decay render fruit suscept invas opportunist pathogen mani studi conduct reveal fruit soften control soften howev soften complex delic life process includ physiolog biochem metabol chang close relat affect environment condit temperatur humid light review current knowledg regard fruit soften mechan summar cell wall metabol cell wall structur chang cell wall degrad enzym plant hormon eth aba iaa br et al transcript factor mad box aperf nac myb bzr epigenet dna methyl histon demethyl histon acetyl diagram regulatori relationship factor provid provid refer cultiv anti soften fruit
|
D005638;D010937
|
T125;T168;T116;T002
|
36,293,334
|
pyramid gna gs ipa exhibit complementari addit effect rice yield pyramid quantit trait loci qtls power approach breed super high yield varieti howev perform qtls improv rice yield vari specif genet background previous studi employ crisprca system target three yield relat gene gna gs ipa japonica zhonghua mutant featur larg panicl big grain steril tiller thicker culm respect paper four pyramid line includ gna gs gna ipa gs ipa gna gs ipa generat convent cross breed test agronom trait analysi show stack line carri larg panicl increas spikelet number main panicl panicl grain weight stack line especi gs ipa gna gs ipa heavier singl mutant gna gs gs ipa produc grain yield per plant singl mutant line pyramid line higher singl mutant transcriptom analysi found improv express level gene relat lipid amino acid carbohydr transport metabol line pyramid three mutant allel possibl result complementari addit effect accord alter gene express pattern relat hormon signal plant growth seed size control character pyramid line present studi investig effect pyramid gene also may provid effici strategi breed super high yield rice reduc time cost develop pyramid line
|
D012275
|
T168;T002
|
36,293,333
|
microb deriv antioxid reduc lipopolysaccharid induc inflammatori respons activ nrf pathway inhibit rosnlrpil signal pathway inflamm play import role innat immun respons yet overproduct inflamm lead varieti chronic diseas associ innat immun system therefor modul excess inflammatori respons consid major strategi treatment inflammatori diseas activ rosnlrpil signal axi suggest key initi phase inflamm previous studi found microb deriv antioxid shown excel antioxid anti inflammatori properti howev mechan action remain unclear current studi aim investig whether could protect cell lps induc oxid stress inflammatori respons modul nrf ros nlrp il signal pathway studi find treatment signific allevi lps induc oxid stress inflammatori respons raw cell signific reduc accumul ros raw cell regul level pro inflammatori factor tnf il inhibit nlrp asc caspas mrna protein level reduc mrna protein level content inflammatori factor il il protect effect signific reduc sirna knockdown nlrp gene presum relat abil inhibit ros nlrp il signal pathway abl reduc accumul ros allevi oxid stress increas content antioxid enzym sod gsh px cat protect effect may due abil induc nrf enter nucleus initi express antioxid enzym antioxid properti enhanc presenc nrf activ sfn sirna knockdown nrf gene antioxid anti inflammatori properti signific affect find suggest may inhibit lps stimul rosnlrpil signal axi activ nrf antioxid signal raw cell result studi found allevi inflammatori respons hold promis therapeut agent inflamm relat diseas
|
D051267;D000071199
|
T123;T116
|
36,293,332
|
antithrombin therapeut intervent sepsi induc coagulopathi dissemin intravascular coagul lesson learn covid associ coagulopathi recent research contribut signific understand pathogenesi acut dissemin intravascular coagul covid consid new under condit dissemin intravascular coagul narrat review current evid present regard biomark differ sepsi induc covid associ coagulopathi support import acquir antithrombin defici earli differenti diagnosi septic coagulopathi potenti impact treatment endogen anticoagul establish new score system septic coagulopathi combin endogen anticoagul biomark activ may allow identif heterogen popul sepsi patient like benefit target specif treatment intervent
|
D004211;D000086382;D001778;D018805
|
T047;T046;T067
|
36,293,331
|
sensit cutan cell lymphoma cell mcl inhibitor correl lack bcl w express long term curat treatment cutan cell lymphoma ctcl remain major challeng therapi resist often base apoptosi defici may depend antiapoptot bcl protein bcl bcl x l bcl w mcl target sever antagonist generat mimic bcl homolog domain bh mimet dysregul overexpress mcl report ctcl use mcl inhibitor appear attract strategi investig effect select mcl inhibitor seri four ctcl cell line comparison abt abt inhibitor bcl bcl x l bcl w two cell line hh hut result signific apoptosi induct decreas cell viabil loss mitochondri membran potenti caspas activ two cell line myla seax remain complet resist invers correl found resist cell high sensit abt sensit cell show moder sensit abt combin abt partial yield synergist effect concern bcl protein express weaker mcl express found resist myla seax bcl bcl x l lowest express found high sensit cell line hh strike differ resist sensit cell identifi bcl w exclus express resist cell thus ctcl may effici target bh mimet provid right target preselect bcl w express may serv suitabl marker
|
D000970;D016410
|
T121;T191;T109
|
36,293,330
|
chitosan hydroxycinnam acid conjug emerg biomateri rise applic biomedicin past thirti year research shown huge potenti chitosan biomed applic drug deliveri tissu engin regener cancer therapi antimicrobi treatment among other one major advantag interest polysaccharid modifi facilit use tailor made applic way molecular structur chitosan conjug multipl molecul modifi mechan biolog chemic properti review conjug chitosan bioactiv molecul hydroxycinnam acid hcas sinc deriv probe enhanc biolog effect chitosan fine tune characterist applic biomed field first main characterist chitosan hcas present current employ conjug strategi chitosan hcas describ final studi biomed applic deriv discuss present limit advantag could lead proxim therapeut use
|
D048271;D000890
|
T121;T109
|
36,293,329
|
tspo pet imag potent non invas biomark diffus intrins pontin glioma patient deriv orthotop rat model diffus intrins pontin glioma dipg first caus cerebr pediatr cancer death great benefit specif non invas biomark patient follow monitor drug efficaci sinc biopsi challeng brain tumor molecular imag may techniqu choic target follow tumor evolut far mr remain imag techniqu refer dipg although often fail defin extent tumor essenti paramet therapeut efficaci assess thank high sensit positron emiss tomographi pet offer uniqu way target specif biomark vivo demonstr patient deriv orthotop xenograft pdox model rat transloc protein kda tspo may promis biomark monitor dipg tumor studi distribut f dpa tspo radioligand rat inocul hsjd dipg cell primari dipg human cell line hsjd dipg high repres pediatr tumor display preval dipg mutat hfa km acvr rh kinet model parametr imag use brain f dpa pet data enabl specif delin dipg tumor area crucial radiotherapi dose manag
|
D005910;D000080443;D020295;D001254
|
T191
|
36,293,328
|
extracellular vesicl isol malign mesothelioma cancer associ fibroblast induc pro oncogen chang healthi mesotheli cell malign mesothelioma aggress tumour pleura mpm peritoneum clinic present advanc stage diseas current therapi margin improv surviv urgent need identifi new treatment carcinoma associ fibroblast caf repres main compon vast stroma within mpm play import role tumour microenviron influenc caf cancer progress aggress metastasi well understood howev role caf deriv extracellular vesicl caf ev promot tumour develop invas underexplor purifi caf ev mpm associ cell healthi dermal human fibroblast examin effect cell prolifer motil data show exposur healthi mesotheli cell ev deriv caf normal dermal human fibroblast ndhf result activ pro oncogen signal pathway increas prolifer motil consist role suppress yes associ protein yap activ mpm result hippo pathway inactiv treatment simvastatin amelior pro oncogen effect instig caf ev mechan involv reduct ev number chang ev cargo collect data determin signific caf deriv ev mesothelioma develop progress suggest new target cancer therapi
|
D000086002;D000072645;D008654;D000067128
|
T026;T191;T025
|
36,293,327
|
quantit nmr base lipoprotein analysi identifi elev hdl triglycerid serum alzheim diseas patient alzheim diseas ad common form dementia elder associ chang lipoprotein metabol perform quantit lipoprotein analysi local cohort cognit impair elder control subject use standard nuclear magnet reson nmr spectroscopi commerci avail quantit nmr base assay cover lipoprotein main subtyp variabl use investig blood serum sampl moder cohort size person femal male includ measur qualiti control addit clinic metadata cerebrospin fluid ad biomark collect use analysi high densiti lipoprotein hdl hdl subfract level most high femal individu mild cognit impair mci follow ad low densiti lipoprotein ldl ldl cholesterol slight elev male ad patient hdl apolipoprotein apo hdl phospholipid hdl triglycerid high abund ad mci women compar men consid clinic biomark tau low densiti lipoprotein vldl vldl intermedi densiti lipoprotein idl triglycerid substanti higher ad compar mci addit triglycerid level correl posit dementia differ lipoprotein serum pattern identifi ad mci control subject interest hdl ldl cholesterol paramet reveal strong gender specif chang context ad driven dementia gender base comparison base smaller sub group low n number sever statist find meet signific threshold multipl comparison test still find suggest serum hdl paramet various triglycerid correl posit ad patholog could read extend lipid travel blood brain barrier support amyloid plaqu format process thereof see herein proof concept quantit nmr base lipoprotein assay generat import high interest data refin ad diagnosi patient stratif especi larger cohort avail
|
D000544
|
T047;T048
|
36,293,326
|
mtor potenti target treatment microbi infect inflammatori bowel diseas colorect cancer mammalian target rapamycin mtor major control number import cellular activ includ protein synthesi cell expans multipl autophagi lysosom function cellular metabol mtor interact specif adaptor protein form two complex mtor complex mtorc mtor complex mtorc mtor signal system regul gene transcript protein manufactur control prolifer cell differenti immun cell tumor metabol due vital role case microbi infect inflamm cancer develop progress mtor consid key therapeut target develop target medic autophagi dysfunct link chang innat adapt immun respons bacteri clearanc defect goblet paneth cell malfunct chang link inflammatori bowel diseas ibd colorect cancer crc pathogenesi preclin clinic data shown inhibit induct autophagi signific potenti translat clinic applic ibd sever crc model mtorc inhibitor found effect recent year number novel mtor inhibitor investig clinic trial number drug shown consider enhanc efficaci combin mtor inhibitor futur develop mtor target medic benefit patient individu therapi advanc innov medicin effect lower drug resist still high demand new find could relev medicin develop pharmacolog modif futur mtor inhibitor research therefor goal review present comprehens account current develop mtor pathway inhibitor emphasi manag microbi infect treatment inflammatori bowel diseas manag colon cancer
|
D015212;D015179
|
T047;T191
|
36,293,325
|
treatment liquid smoke certain chemic constitu preval smoke reduc phloem vascular sectori sunflow improv growth mani higher plant possess physiolog organ base upon carbon economi part photosynth partit accord relat strength plant sink tissu mani speci also close relationship partit phyllotaxi vascular connect give rise sectori pattern alloc examin influenc smoke certain chemic constitu preval smoke includ catechol resorcinol hydroquinon phloem vascular sectori common sunflow helianthi annuus l model plant sectori administ radioact carbon singl sourc leaf co c photosynth alloc pattern examin use autoradiographi aqueous dilut liquid smoke treat soil caus fold fold reduct phloem sectori sink leav root respect treatment catechol ihydroxybenzen resorcinol dihydroxybenzen polyphenol constitu preval smoke caus similar reduct phloem sectori target sink tissu howev treatment hydroquinon dihydroxybenzen effect final longer term effect smoke exposur plant growth perform examin use outdoor pot plant grown season plant expos liquid smoke treatment soil week basi larger thicker leav possess greater lignin content untreat control plant also thicker stem although lignin content control addit plant expos treatment produc twice number flower differ disk floret diamet untreat control altogeth loss phloem sectori exposur liquid smoke sunflow model benefit plant perform
|
D052585;D006368
|
T002
|
36,293,324
|
mother fetus immun cross talk coordin extrins intrins embryo gene express nois growth stabil development instabl di thought invers relat capac organ buffer develop random genet environment perturb di repres trait inter intra individu variabl inter individu variabl invers refer canal indic capabl organ reproduc trait individu individu intra individu variabl reflect organ capabl stabil trait intern condit symmetr trait express fluctuat asymmetri fa repres trait random variabl condit environment fluctuat clear statist term di partit extrins canal intrins fa compon trait variancenois establish simpl statist framework dissect part symmetr trait variancenois use pca princip compon analysi project leftright measur eigenvector follow gamlss general addit model locat scale shape model eigenvalu first eigenvalu repres extrins second intrins di compon appli framework investig impact mother fetus major histocompat complex mhc mediat immun cross talk gene express nois development stabil show intrins gene nois entir transcript landscap could estim small subset random select gene use diagnost set gene found allogen mhc combin tend decreas extrins intrins gene nois cblj embryo develop surrog nod scid balbc mother intrins gene nois negat correl growth embryon mass level placent growth factor plgf vascular endotheli growth factor vegf howev posit associ phenotyp growth instabl nois plgf mammal mother fetus mhc interact play signific role develop contribut fit offspr result demonstr posit impact distant mhc combin embryon growth could mediat reduct intrins gene nois follow development stabil growth
|
D009035;D016228
|
T092;T099;T116;T123
|
36,293,323
|
rhfgf protect epiderm cell uvb induc apoptosi activ ampk mediat autophagi ultraviolet irradi especi ultraviolet b uvb irradi increas risk various skin diseas sunburn photo age cancer howev drug avail treat skin lesion therefor discoveri drug improv health irradi skin urgent need fibroblast growth factor fgf metabol factor play import role protect repair various type patholog damag effect fgf skin injuri caus uvb irradi focus studi found uvb irradi promot express fgf protein mous epiderm cell exogen recombin human fgf rhfgf protect mous skin tissu uvb induc injuri rhfgf inhibit inflammatori respons epiderm cell apoptosi well promot autophagi uvb irradi mice moreov found rhfgf protect hacat cell uvb induc apoptosi protect effect enhanc treatment autophagi activ rapamycin inhibit treatment autophagi inhibitor methyladenin amp activ protein kinas ampk cellular energi sensor regul autophagi rhfgf increas express p ampk protein epiderm cell irradi uvb vivo vitro moreov rhfgf increas autophagi level viabil diminish treatment ampk inhibitor compound c rhfgf protect epiderm cell uvb induc apoptosi induc ampk mediat autophagi
|
D055372;D001343
|
T126;T116;T043
|
36,293,322
|
assess dna damag effect ioniz radiat use plasmid dna plasmid dna use investig dna damag effect ioniz radiat studi explor feasibl plasmid dna base detector assess dna damag effect two radiotherapi x ray beam qualiti undergo return shipment km two institut detector consist amp nbsp l pbr dna enclos aluminum seal nine cylindr caviti drill polycarbon block ship toronto canada irradi either amp nbsp kvp amp nbsp amp nbsp mv amp nbsp x ray beam dose gy triplic ship back san diego usa toronto return shipment also includ non irradi control kept separ set control san diego san diego quantifi dna singl strand break ssbs doubl strand break dsbs appli nth fpg enzym quantifi oxid base damag rate dsbsgyplasmid amp nbsp greater kvp mv irradi amp nbsp kvp irradi also result time dsbsssb amp nbsp mv beam demonstr detector sensit enough quantifi relat dna damag effect even shipment thousand kilomet
|
D000535;D004249
|
T121;T196;T049
|
36,293,321
|
alter gene pair correl potenti diagnost marker colon cancer colorect cancer crc lead caus death cancer canada earli detect crc remain crucial manag diseas prognosi improv patient surviv also facilit prevent screen treatment diseas progress chronic stage studi develop strategi identifi colon cancer biomark gene express gene pair correl use rna seq dataset tcga coad panel gene includ upregul gene downregul gene gene involv signific alter gene pair select potenti biomark colon cancer signatur set gene could use earli diagnosi furthermor strategi could appli type cancer
|
D003110
|
T191
|
36,293,320
|
kdf novel variant caus uniqu dental oral epitheli defect keratinocyt differenti factor kdf recent identifi rare candid gene human tooth agenesi howev kdf relat morpholog characterist patholog chang dental tissu oral epithelium remain larg unknown employ whole exom sequenc wes sanger sequenc screen suspect variant cohort tooth agenesi patient segreg novel kdf heterozyg missens variat cg gt c prp non syndrom tooth agenesi famili essenti bioinformat analys tertiari structur predict perform analyz structur chang function impact novel kdf variant subsequ function assess use top flashfop flash luciferas report system demonstr kdf variant suppress activ canon wnt signal cell comprehens investig kdf relat oral morpholog anomali perform scan electron microscopi ground section lower right later decidu incisor extract proband histopatholog assess gingiva phenotyp analys reveal seri tooth morpholog anomali relat kdf variant rp includ shovel shape lingual surfac incisor cornicion shape margin ridg anomal morpholog occlus groov premolar molar notabl keratin gingiv epithelium abnorm reveal proband character epitheli dyskeratosi residu nuclei indistinct stratum granulosum epitheli hyperprolifer impair epitheli differenti find reveal new development anomali tooth gingiv epithelium non syndrom tooth agenesi individu novel pathogen kdf variant broaden phenotyp spectrum kdf relat disord provid new evid crucial role kdf regul human dental oral epitheli develop
|
D000848
|
T019
|
36,293,319
|
identif prognost gene signatur develop scrna seq base integr approach predict recurr chemotherapi benefit stage ii iii colorect cancer prospect identif robust biomark relat prognosi adjuv chemotherapi becom necessari critic step predict benefit adjuv therapi patient stage ii iii colorect cancer crc clinic treatment propos singl cell base prognost biomark recognit approach identifi construct crc regul prognost signatur cupsig cdpsig integr scrna seq bulk dataset found gene cupsig cdpsig known diseas gene good prognost abil crc valid dataset multivari analysi confirm two independ prognost factor diseas free surviv dfs signific cupsig cdpsig could effect predict adjuv chemotherapi benefit drug treat valid dataset addit also perform well patient cms subtyp subsequ analysi drug sensit show express two signatur signific associ sensit crc cell line multipl drug summari propos novel prognost biomark identif approach could use identifi novel prognost marker stage ii iii crc patient undergo adjuv chemotherapi facilit person treatment
|
D014408;D015179
|
T123;T191
|
36,293,318
|
genom basi individu differ suscept neurotox effect diesel exhaust air pollut known environment health hazard major sourc air pollut includ diesel exhaust de initi research de focus respiratori morbid howev recent exposur de associ neurolog development disord neurodegener studi investig effect sub chronic inhal exposur de neuroinflammatori marker two inbr mous strain sex includ whole transcriptom examin medial prefront cortex expos age male femal cblj b dbaj mice de cool dilut hepa filter compress air h per day day week week control anim expos hepa filter air schedul de expos anim prefront cortex harvest analyz proinflammatori cytokin gene express il il tnf transcriptom wide respons rna seq observ differenti cytokin gene express strain sex de expos vs control expos group il tnf il rna seq identifi differenti express gene air de treatment relat natur killer cell mediat cytotox per kyoto encyclopedia gene genom pathway overal data show differenti strain relat effect de neuroinflamm neurotox demonstr b suscept gene express chang due de exposur result import b mice often use default mous model de studi strain relat effect de neurotox warrant expand studi
|
D000393;D020258
|
T131;T037
|
36,293,317
|
critic overview hepat factor link non alcohol fatti liver diseas acut kidney injuri physiolog therapeut implic non alcohol fatti liver diseas nafld defin combin group progress diseas present differ structur featur liver differ stage diseas accord epidemiolog survey live standard improv global preval nafld increas acut kidney injuri aki class clinic condit character rapid declin kidney function nafld aki major public health diseas high preval mortal respect worldwid place heavi burden societ healthcar system clinic observ patient nafld aki suggest possibl associ two diseas howev littl known pathogen mechan link nafld aki combin diseas poor treat previous studi reveal liver deriv factor transport distal organ via circul kidney elicit specif effect note nafld affect express mani hepat factor studi mechan wherebi nafld mediat generat hepat factor lead aki lack consid uniqu posit hepat factor coordin system energi metabol maintain energi homeostasi hypothes effect nafld limit structur function chang liver may also involv entir bodi via hepat factor eg play import role develop aki rais question whether analog benefici hepat factor inhibitor detriment hepat factor could use treatment nafld mediat hepat factor driven aki metabol disord accord review describ system effect sever type hepat factor particular focus possibl link hepat factor whose express alter nafld aki also summar role key hepat factor metabol control mechan discuss possibl use prevent treatment progress metabol diseas
|
D065626;D058186
|
T047;T037
|
36,293,316
|
estim similar protein pocket exponenti increas public avail protein structur comparison protein bind site natur emerg scientif topic explain observ generat hypothes ligand design notabl predict ligand select target explain polypharmacolog design target focus librari current review summar state art comput method appli pocket detect comparison well structur druggabl estim major strength weak current pocket descriptor align method similar search algorithm present last exhaust survey retrospect prospect applic divers medicin chemistri scenario illustr capabl exist method hurdl still need overcom accur predict
|
D015195;D011506
|
T090;T116;T123
|
36,293,315
|
identif matur plasma cell index high sensit droplet digit pcr assay gene express signatur valid newli diagnos multipl myeloma patient dna microarray rna base sequenc approach consid import discoveri tool clinic medicin howev cross platform reproduc studi undertaken far highlight microarray abl accur measur gene express particular express low level consid employ digit pcr assay ddpcr valid gene signatur previous identifi gene express profil signatur includ ten hedgehog hh pathway gene abl stratifi multipl myeloma mm patient accord self renew status result show design assay abl valid gene express data retrospect well prospect cohort addit plasma cell differenti status determin ddpcr confirm techniqu flow cytometri allow identif patient immatur plasma cell phenotyp ie express cdcd marker upregul hh gene compar other whose plasma cell lose express marker differenti knowledg first technic report gene express data valid ddpcr instead classic qpcr approach permit identif matur index integr molecular phenotyp data abl possibl defin upfront differenti status mm patient would clinic relev futur
|
D010950;D009101
|
T191;T025
|
36,293,314
|
origin effici antibiot adjuv strategi enhanc activ macrolid antibiot gram negat resist strain gram negat bacteria report signific caus infect communiti nosocomi set consid one greatest threat public health spread bacteria drug resist lack effect altern treatment option remain problemat herein report promis strategi combat gram negat resist strain consist combin macrolid antibiot polyaminoisoprenyl adjuv deriv lead signific decreas antibiot resist
|
D000900;D006090
|
T121;T007;T195
|
36,293,313
|
potenti use autogen tendon graft inject bone marrow aspir rabbit meniscectomi model bone marrow aspir bma excel sourc cell growth factor use success bone cartilag soft tissu heal studi aim investig histolog biomechan properti autogen tendon graft inject bma protect effect degen chang rabbit model menisc defect adult white rabbit divid untreat tendon tendon bma group menisc defect creat knee tendon graft articular cartilag status evalu macroscop histolog analysi week postop among three group tendon graft tendon tendon bma group use biomechan evalu week postop menisc cover ratio tendon bma group better tendon untreat group week postop matrix around central portion cell tendon bma group posit stain safranin toluidin blue stain metachromasia week histolog score tendon graft tendon bma group signific higher untreat tendon group week postop tendon bma group cartilag eros shown week develop slowli better preserv week compar untreat tendon group histolog score articular cartilag signific better tendon bma group week compress stress tendon graft tendon bma group signific higher tendon group week postop transplant autogen tendon graft inject bma improv histolog score regener menisc tissu effect tendon untreat group prevent cartilag degener rabbit model massiv menisc defect
|
D000074403;D002358
|
T061;T024
|
36,293,312
|
molecular character plasma hdl ldl vldl lipid cargo atherosclerot patient advanc carotid lesion preliminari report carotid atherosclerosi repres relev healthcar problem sinc unstabl plaqu respons approxim neurolog event name transient ischem attack stroke although statin treatment proven effect reduc ldl cholesterol onset acut clinic event residu risk may persist suggest need detect reliabl molecular marker use identif patient higher risk regardless optim medic therapi regard sever line evid show relationship among specif biolog activ plasma lipid atherosclerosi acut clinic event perform select reaction monitor base high perform liquid chromatographi tandem mass spectrometri srm base hplc msms analysi plasma hdl ldl vldl fraction purifi isopycn salt gradient ultracentrifug twenti eight patient undergo carotid endarterectomi either hard soft plaqu aim character specif lipidom pattern associ featur carotid plaqu instabl one hundr thirti lipid speci encompass differ lipid sub class monitor supervis multivari analysi show lipid belong phosphatidylethanolamin pe sphingomyelin sm diacylglycerol dg class most contribut discrimin within lipoprotein fraction accord plaqu typolog differenti analysi evidenc signific dysregul ldl pe sm sm two group patient adj p valu threshold log fc use approach ldl associ marker plaqu vulner identifi line current knowledg key role phospholipid lipoprotein metabol cardiovascular diseas proof concept studi report promis result show lipoprotein lipidom may present valuabl approach identifi new biomark potenti clinic relev
|
D019161;D050197;D058226
|
T121;T109;T020;T047;T046;T031
|
36,293,311
|
nrd mediat cell senesc mous heart deriv sca cd cell sca cd cell resid cardiac progenitor cell found mani mammalian tissu includ heart abl differenti cardiomyocyt vitro vivo previous work indic heart deriv sca cd cell increas nrd mrna level nrd age howev nrd affect senesc sca cd cell
|
D000950;D008565
|
T129;T116;T123;T192
|
36,293,310
|
mutat hotspot chang substrat specif n acetylhexosaminidas librari glcnacas n acetylhexosaminidas talaromyc flavus tf hex ec exo glycosidas dual activ cleav n acetylglucosamin glcnac n acetylgalactosamin galnac unit carbohydr target mutat hotspot activ site residu glu prepar librari ten mutant variant substrat specif signific shift toward glcnacas activ suitabl mutat identifi silico method optim microtit plate screen method yeast pichia pastori express system requir correct fold tetramer fungal n acetylhexosaminidas wild type tf hex promiscu galnacaseglcnacas activ ratio best singl mutant variant gluhi featur fold increas select toward glcnac compar wild type sever prepar variant particular gluthr tf hex signific stronger transglycosyl capabl wild type afford longer chitooligom behav like transglycosidas studi demonstr potenti mutagenesi alter substrat specif glycosidas
|
D001619;D000117
|
T121;T126;T116;T109
|
36,293,309
|
corticosteron glucocorticoid receptor apcreb axi inhibit lutein hormon receptor express mous granulosa cell stress condit lutein hormon lh mediat ovul inhibit result insuffici oocyt product excret follicular develop bodi stress larg amount corticosteron cort generat lead disord bodi endocrin system damag bodi previous work show cort block follicular develop mice sinc lh act bind lutein hormon receptor lhcgr present studi aim investig whether corticosteron cort influenc lhcgr express mous ovarian granulosa cell gcs purpos three week old icr femal mice inject intraperiton pregnant mare serum gonadotropin pmsg addit treatment group inject cort mgmous interv h control group inject volum methyl sulfoxid dmso gcs collect h h h pmsg inject vitro experi mous gcs obtain healthi follicl treat cort alon togeth inhibitor glucocorticoid receptor nrc result show cort caus downregul lhcgr express gcs accompani impair cell viabil moreov effect cort mediat bind receptor nrc gcs investig reveal nrc might regul transcript lhcgr inhibit express lhcgr transcript factor includ ap creb taken togeth find suggest possibl mechan cort induc anovul involv inhibit lhcgr express gcs cort nrc apcreb axi
|
D011974;D003345
|
T121;T116;T109;T192;T125
|
36,293,308
|
involv il signal pathway anti anhedon effect antidepress agomelatin chronic mild stress model depress neuroinflamm emerg import factor molecular underpin major depress disord mdd pathophysiolog mechan action antidepress among inflammatori mediat dysregul depress patient interleukin il recent propos play crucial role il activ signal pathway compris jakstat protein character specif negat feedback loop exert cytoplasm protein suppressor cytokin signal soc base explor potenti involv il signal abil antidepress drug agomelatin normal anhedon like phenotyp induc rat chronic stress exposur aim adult male wistar rat subject chronic mild stress cms paradigm chronic treat vehicl agomelatin behavior evalu assess sucros consumpt test wherea molecular analys perform prefront cortex found cms abl stimul il product signal includ soc gene protein express soc mediat feedback loop inhibit fail suppress il cascad stress anim convers agomelatin treatment normal stress induc decreas sucros consumpt restor negat modul il signal via soc express activ result provid addit inform pleiotrop mechan contribut agomelatin therapeut effect
|
D015850;D003865
|
T129;T116;T048
|
36,293,307
|
drug resist dapson rifampicin ofloxacin resist relat gene mutat featur leprosi patient systemat review meta analysi dapson dds rifampicin rif ofloxacin ofl drug recommend world health organ treatment leprosi context leprosi resist drug occur main due mutat target gene folp rpob gyra import monitor antimicrobi resist patient leprosi therefor perform meta analysi drug resist mycobacterium lepra mutat profil target gene paper limit studi period may search pubm web scienc wos scopus embas databas identifi studi two independ review extract studi data mutat drug resist rate estim stata result demonstr drug resist rate ci subgroup analysi show highest resist rate western pacif region ci higher vs conclud rate among new case ci lower relaps ci mutat rate folp rpob gyra ci ci ci respect rate polygen mutat analysi use drug resist strain research subject found codon ser pro ala rpob folp gyra common mutat site determin region drdr addit common substitut pattern folp rpob gyra proleu serleu alav studi found higher proport patient develop resist drug rate increas sinc continu pose challeng clinician addit amino acid alter sequenc drdr region substitut pattern mention studi also provid new idea clinic treatment option
|
D012293;D007918
|
T121;T047;T195;T109
|
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