PMID
int64 35.7M
36.4M
| Title/Abstract
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36,291,147
|
express quantit trait locus studi non syndrom cleft lip without cleft palat gwas variant lip tissu non syndrom cleft lip without cleft palat nsclp complex diseas strong genet compon loci identifi associ risk nsclp genom wide associ studi gwass major variant map non code region genom express quantit trait locus eqtl studi increas integr gwass identifi target gene non code variant studi generat uniqu lip specif eqtl dataset nsclp patient total eqtl snps esnp eqtl gene identifi multipl correct integr nomin eqtl snps nsclp risk snps identifi variant associ express gene lip tissu function annot analysi indic risk esnp signific enrich transcript regul chromatin open region genom suscept gene enrich cell fate determin pluripot stem cell wnt signal pathway final suscept gene differenti express nsclp case control studi summari generat uniqu lip specif eqtl resourc identifi multipl associ nsclp risk loci inform function studi nsclp biolog
|
D002971;D002972;D040641
|
T019;T028
|
36,291,146
|
immunotherapi non small cell lung cancer patient driver alter new strategi mani year research tri develop effect way fight lung cancer caus largest number cancer relat death among men women worldwid advanc treatment near non small cell lung cancer nsclc type includ immunotherapi immun checkpoint inhibitor ici main anti program death anti program death ligand monoclon antibodi anti pd pd l mab monotherapi combin strategi despit signific advanc long surviv achiev case new solut constant sought one question rais oncologist efficaci ici patient molecular driver alter especi possibl use molecular target therapi exhaust eg due resist tyrosin kinas inhibitor studi investig problem still poor describ among probabl immunotherapi failur reason low immunogen tumor one driver mutat list nevertheless case therapi effici research requir establish manag nsclc patient oncogen driver abnorm aim articl review current discoveri matter
|
D002289;D007167;D008175;D058990
|
T061;T191
|
36,291,145
|
new insight vitro angiogenesi model stretch tube matrigel base tube format assay simpl wide accept angiogenesi model vitro extracellular matrix em protein growth factor gfs matrigel tm exclus trigger endotheli cell ec tubular network etn format co cultur ec mesenchym stromal cell mscs anoth reliabl vitro angiogenesi assay mscs modul etn format intercellular interact supplier em gfs aim present studi compar express profil ec model reveal upregul upa upar jag notch gene dividingmigr ec ec experiment model h express endotheli mesenchym transit gene larg increas co cultur ec wherea notch hippo signal pathway gene upregul ec matrigel tm show co cultur model basement membran bm deposit limit cell cell contact contrast matrigel tm repres fulli pre assembl bm matrix suggest etn co cultur model still dynam process due immatur bm wherea ec matrigel tm assay seem final stage etn format
|
D018919;D059630
|
T039;T025
|
36,291,144
|
biomechan assess macro calcif human carotid atherosclerosi impact smooth muscl cell phenotyp intim calcif vascular stiffen predomin featur end stage atherosclerosi howev role atherosclerot plaqu instabl extent spatial distribut calcif influenc plaqu biolog remain unclear recent show extens macro calcif stabil featur late stage human lesion associ reacquisit differenti properti plaqu smooth muscl cell smcs extracellular matrix ecm remodel hypothes biomechan forc relat macro calcif within plaqu influenc smc phenotyp contribut plaqu stabil generat finit element model fem pipelin assess plaqu tissu stretch base imag analysi preoper comput tomographi angiographi cta carotid atherosclerot plaqu visual calcif soft tissu lipid extracellular matrix within lesion biomechan stretch signific reduc tissu close proxim macro calcif increas level observ within distant soft tissu appli data vitro stretch model primari vascular smcs reveal upregul typic marker differenti smcs contractil low stretch condit also imped smc align contrast high stretch condit combin calcifi condit induc smc apoptosi find suggest load bear capac macro calcif influenc smc differenti surviv contribut atherosclerot plaqu stabil
|
D058226;D002340;D002114
|
T047;T046;T020;T031
|
36,291,143
|
dlx gene develop mainten vertebr skeleton implic human patholog skelet shape mechan properti defin larg extent vertebr morpholog physic capac develop skelet morphogenesi result dynam communic chondrocyt osteoblast osteoclast cellular compon skeleton later life skelet integr depend regulatori cascad assur equilibrium bone format resorpt final age skelet catabol prevail anabol result progress skelet degrad cellular process depend transcript cascad control cell divis differenti cell type distal less dlx homeobox transcript factor direct involv determin prolifer differenti chondrocyt osteoblast indirect osteoclast involv dlx gene regul skelet format well analyz thank sever mutant mous model role gene mainten bone integr partial studi import dlx gene adult bone tissu evidenc central role regulatori pathway involv osxsp runx two major master gene osteogenesi dlx gene appear involv sever bone patholog includ exampl osteoporosi inde least five larg scale gwas studi aim detect loci associ human bone miner densiti bmd identifi known dlx regulatori region within chromosom q proxim semfljdss code sequenc suggest dlx express critic determin healthi bmd review aim summar major find concern involv dlx gene skelet develop homeostasi involv skelet age patholog
|
D001842;D001846;D018398;D014157
|
T123;T116;T024;T042;T023
|
36,291,142
|
key role hyaluronan metabol develop brain metastas tripl negat breast cancer breast cancer bc second common caus brain metastas bm bcbm patient reduc qualiti life poor prognosi hyaluronan ha particular hyaluronidas hyal alreadi link develop bcbm therefor present interest opportun develop new effect therapeut option ha metabol discov crisprca mediat knockout hyal shrna mediat regul ha receptor cd brain seek tripl negat breast cancer tnbc cell line mda mb br therefor impact hyal adhes disrupt invas brain endothelium vitro vivo studi analysi point key role hyal low molecular weight ha lmw ha format pericellular ha coat bc cell turn promot tumor cell adhes disrupt migrat brain endothelium vitro well extent bm vivo cd knockdown mda mb br signific reduc pericellular ha coat cell consequ tumor cell adhes invas brain endothelium thus interact hyal generat lmw ha fragment ha receptor cd might repres potenti target futur therapeut option bc patient high risk cerebr metastas format
|
D001932;D006820;D006821;D064726
|
T121;T123;T116;T109;T191;T126;T122
|
36,291,141
|
trafp jnk signal crosstalk intracellular trailcaspas induc apoptosi acceler ros driven cancer cell specif death cd capac induc tumour cell specif apoptosi repres uniqu featur tnf receptor tnfr famili member cd recent studi signal event trigger membran present ligand cdl mcdl normal malign epitheli cell start unravel exquisit context cell type specif function effect cd demonstr comparison carcinoma mcdl trigger strike rapid apoptosi colorect carcinoma crc cell underpin abil entrain two concurr oper signal axe cd ligat initi activ tnfr associ factor traf subsequ nadph oxidas nox apoptosi signal regul kinas ask signal induct reactiv oxygen speci ros mediat pjnk ros depend cell death point pjnk signal direct activ mitochondri pathway trigger rapid induct intracellular tnf relat apoptosi induc ligand trail signal intern compart initi extrins caspas asscoci apoptosi lead truncat bid tbid activ mitochondri signal p jnk essenti direct mitochondri apoptosi induct trailcaspas tbid pathway involv follow function hierarchi tempor control interplay p function requir jnk phosphoryl engag intrins extrins pathway activ apoptosi via two signal simultan cd acceler crc cell death find unravel multi facet properti cdmcdl dyad highlight novel tnfr crosstalk acceler tumour cell specif death may implic use cd therapeut target
|
D017209;D019013;D017382;D048008;D053221;D048051;D048670;D015179
|
T129;T123;T116;T192;T196;T191;T126;T043
|
36,291,140
|
target asparagin synthetas tumorgen use patient deriv tumor initi cell reprogram energi metabol regard one hallmark cancer particular oncogen ras shown critic regul cancer metabol recent asparagin metabol heavili investig novel target cancer treatment exampl knott et al show asparagin bioavail govern metastasi breast cancer model gwinn et al report therapeut vulner asparagin biosynthesi kras driven non small cell lung cancer previous report kras mutat crc cell adapt glutamin deplet upregul asparagin synthetas asn enzym synthes asparagin aspart previous studi assess efficaci asparagin deplet use human cancer cell line present studi evalu clinic relev asparagin deplet use novel patient deriv spheroid xenograft pdsx mous model first examin asn express spheroid line found line display high asn express wherea line show asn express next determin role asparagin metabol tumor growth establish asn knockdown spheroid line use lentivir short hairpin rna construct target asn vitro cell prolifer assay demonstr signific decreas cell prolifer upon asparagin deplet asn knockdown spheroid line observ control spheroid line addit examin asparagin inhibit anti leukemia drug l asparaginas l asp observ consider reduct cell prolifer low concentr uml asn knockdown spheroid line wherea exhibit limit inhibit control spheroid line concentr final use pdsx model assess effect asparagin deplet tumor growth vivo nude mice inject asn knockdown control spheroid line administ l asp day day surpris mice inject asn knockdown spheroid administr l asp dramat inhibit tumor engraft hand mice inject control spheroid administr l asp effect tumor growth inhibit result suggest asn inhibit could critic target asparagin metabol cancer
|
D001217;D063646
|
T191;T126;T116
|
36,291,139
|
efficaci faecal microbiota transplant rectal bacteriotherapi patient recurr clostridioid difficil infect retrospect cohort studi effect treatment recurr clostridioid difficil infect cdi faecal microbiota transplant fmt howev optim rout administr thus far unknown retrospect cohort studi patient sought evalu efficaci treatment fmt capsul fmt enema rectal bacteriotherapi rbt five year period primari endpoint clinic resolut cdi eight week secondari endpoint time recurr death follow period proport patient clinic resolut fmt capsul group fmt enema group rbt group correspond adjust odd ratio ci fmt capsul group compar fmt enema ci compar rbt hazard ratio recurr within first month follow ci fmt capsul group compar fmt enema ci compar rbt differ mortal conclus fmt capsul effect fmt enema rbt treatment recurr cdi reduc risk recurr
|
D016360;D003015
|
T047;T007;T037
|
36,291,138
|
research progress role pyroptosi myocardi ischemia reperfus injuri myocardi ischemia reperfus injuri miri result aggrav myocardi injuri caus rapid recan ischem myocardium past year grow interest investig complex pathophysiolog mechan miri identif effect target drug allevi miri current pyroptosi type inflammatori program death receiv greater attent involv miri develop combin mechan miri oxid stress calcium overload necroptosi apoptosi therebi form intertwin associ differ pathway affect miri regul common pathway molecul review describ pyroptosi mechan miri relationship mechan also highlight non code rnas non cardiomyocyt regul cardiomyocyt pyroptosi mediat associ pathway protein particip initi develop miri research progress novel small molecul drug clinic drug tradit chines medicin etc regul pyroptosi play crucial role effect miri allevi compar research matur mechan research studi pyroptosi miri inadequ although mani relat protect drug identifi drug general lack clinic applic necessari explor verifi drug expand applic clinic set earli inhibit miri target regul pyroptosi key concern need address futur studi
|
D015428
|
T046
|
36,291,137
|
follicl stimul hormon allevi ovarian age modul mitophagi glycophagi base energi metabol hen predomin hormon reproduct axi follicl stimul hormon fsh known primari surviv factor follicular growth studi allevi effect fsh age chicken granulosa cell gcs investig result show fsh activ mitophagi reliev mitochondri edema gal induc senesc gcs evidenc increas number mitophagosom well increas mitochondria light chain lc coloc mitophagi activ accompani activ amp activ protein kinas ampk signal pathway furthermor upregul glycophagi demonstr increas interact starch bind domain protein stbd gaba type receptor associ protein like gabarapl gal induc senesc gcs fsh treatment promot glycophagi accompani pikakt activ pik inhibitor ly akt inhibitor gsk attenu effect fsh glycophagi glycolysi inhibit fsh mediat autophagi attenu protect effect fsh natur age gc prolifer glycolysi simultan blockag pikakt ampk signal also abolish posit effect fsh natur senesc ovarian energi regul data reveal fsh prevent chicken ovarian age modul glycophagi mitophagi base energi metabol pikakt ampk pathway
|
D005640;D019869
|
T125;T121;T126;T116
|
36,291,136
|
key gene associ pyroptosi gout construct mirna mrna regulatori network studi aim analyz key hub gene relat pyroptosi gout construct mirna mrna regulatori network use bioinformat tool elucid pathogenesi gout offer novel idea develop target therapeut strategi gout
|
D053263;D006073;D035683;D000069292
|
T123;T114;T043;T047;T044
|
36,291,135
|
gut kidney impair process adenin combin folium senna induc diarrhea associ interact lactobacillus intestinali bacteroid acidifacien acet acid inflamm kidney function extens evid suggest gut microbiota may interact kidney play central role pathogenesi diseas howev associ gut microbiota kidney diarrhea remain unclear
|
D005232;D014409;D000069196;D001439;D007778;D003092;D007674
|
T129;T123;T007;T116;T109;T047;T001
|
36,291,134
|
development potenc metabol trait extend pluripot faith transfer somat cell via cell fusion induc reprogram novel cell type eight cell stage embryo extend pluripot stem cell epsc known divers differenti potenc extraembryon embryon lineag suggest new possibl development research model although various featur epsc defin abil direct transfer extend pluripot differenti somat cell cell fusion remain elucid deriv epsc eight cell mous embryo confirm extend pluripot molecular level extraembryon differenti abil fuse og rosa neural stem cell nscs polyethylen glycol peg mediat method analyz result fuse hybrid cell exhibit pluripotenti marker upregul epsc specif gene express furthermor hybrid cell contribut extraembryon embryon lineag vivo vitro rna sequenc analysi confirm hybrid cell show distinct global express pattern resembl epsc without parent express nsc marker indic complet acquisit extend pluripot erasur somat memori nscs furthermor ultrastructur observ metabol analysi confirm hybrid cell rearrang mitochondri morpholog bival metabol profil epsc conclus extend pluripot epsc could transfer somat cell fusion induc reprogram
|
D039904
|
T025
|
36,291,133
|
molecular mechan under twin twin transfus syndrom twin twin transfus syndrom uniqu diseas serious complic occur monochorion multipl pregnanc various placent complic includ hypoxia anemia increas oxid stress ischemia reperfus injuri fetoscop laser photocoagul minim invas surgic procedur seal placent vascular anastomos twin dramat improv surviv rate twin twin transfus syndrom howev fetal demis still occur suggest presenc caus placent vascular anastomos placent insuffici consid main caus fetal demis case howev littl known under molecular mechan inde associ pathogen mechan involv twin twin transfus syndrom placenta sever molecul pathway vascular endotheli growth factor renin angiotensin system make difficult understand under patholog condit current effect strategi focus mechan clinic practic certain type cell death due oxid stress might occur placenta elucid molecular mechan under cell death help manag prevent review report molecular mechan under develop twin twin transfus syndrom effect manag prevent fetal demis fetoscop laser photocoagul
|
D005313;D005330;D017075
|
T061;T046
|
36,291,132
|
maoa uvntr genet variant major depress disord systemat review major depress disord mdd high preval multifactori psychopatholog affect neurotransmitt level monoamin oxidas maoa influenc sever neural pathway modul level systemat review per prisma protocol peco strategi endeavor understand maoa uvntr polymorph influenc mdd evalu rr r genotyp frequenc fluctuat mdd patient differ popul search web scienc pubm virtual health librari embas databas elig origin articl brought data genotyp frequenc relat maoa uvntr variant patient mdd exclud studi incomplet data includ statist data review meta analys abstract initi found articl remov duplic appli inclusionexclus criteria seven articl remain popul sampl studi predomin asian high r r allel frequenc notabl observ higher rr femal r male genotyp frequenc healthi control group higher rr femal r male genotyp frequenc mdd group major differ popul despit similar articl analyz still consensus maoa uvntr variant role mdd pathogenesi
|
D003865;D018598;D008995
|
T123;T116;T126;T114;T048
|
36,291,131
|
iglon regul myogenesi via promot cell adhes maintain myotub orient immunoglobulin like cell adhes molecul iglon glycosylphosphatidylinositol anchor membran protein associ neuron growth connect defici link increas fat mass low muscl mass adequ inform iglon lack especi context skelet muscl studi report iglon profus express mous muscl intens local cell membran iglon express elev ctx inject mous muscl confirm role muscl regener abund express high concentr cell cell adhes interact site muscl differenti iglon inhibit profound affect myotub align direct analysi confirm effect addit result demonstr link iglon lipid raft myogen differenti suggest iglon promot differenti increas lipid raft accumul find support notion well align environ promot myoblast differenti collect iglon play novel role myogenesi regener facilit myotub orient involv lipid raft accumul
|
D017261;D024510
|
T123;T043;T042;T109
|
36,291,130
|
metabol advantag oh versus oh supplement infantil nephropath cystinosi associ adipos tissu brown muscl wast manifest infantil nephropath cystinosi inc often includ cachexia defici circul vitamin metabolit examin impact oh versus oh replet ctns null mice mous model inc six week intraperiton administr oh gkgday oh ngkgday result ctns mice correct low circul oh oh concentr oh administr ctns mice normal sever metabol paramet characterist cachexia well muscl function vivo oh administr oh ctns mice increas muscl fiber size decreas fat infiltr skelet muscl accompani reduct abnorm muscl signal pathway oh administr effect conclus oh supplement exert metabol advantag oh supplement amelior muscl atrophi fat brown ctns mice
|
D002117;D002100
|
T121;T184;T127;T109;T125
|
36,291,129
|
defici sarcolemma repair al novel mechan therapeut potenti plasma membran sarcolemma skelet muscl myofib suscept injuri caus physic chemic stress normal daili movement andor diseas condit acut plasma membran disrupt normal compens intrins membran reseal process involv interact multipl intracellular protein includ dysferlin annexin caveolin mitsugumin mg trim new evid compromis muscl sarcolemma repair mechan amyotroph later sclerosi al mitochondri dysfunct proxim neuromuscular junction nmjs increas oxid stress trigger mg aggreg loss function compromis membran repair worsen sarcolemma fragil amplifi oxid stress vicious cycl articl review exist literatur support concept al diseas oxid stress induc disrupt muscl membran repair compromis integr nmjs henc augment muscl membran repair mechan could repres viabl therapeut strategi al
|
D000690;D012508;D012038
|
T026;T047;T042
|
36,291,128
|
neutral cb receptor antagonist pharmacotherapi substanc use disord rational evid challeng cannabinoid receptor cbr one major target medic develop treat substanc use disord sud earli studi indic rimonab select cbr antagonist invers agonist profil high promis therapeut sud howev advers side effect depress suicid led withdraw clinic trial worldwid consequ much research interest shift develop neutral cbr antagonist base recognit rimonab side effect may relat invers agonist profil articl first review rimonab research background potenti pharmacotherapi sud discuss possibl mechan under therapeut anti addict effect versus advers effect last discuss rational develop neutral cbr antagonist potenti treatment sud support evid recent research challeng strategi conclud develop neutral cbr antagonist without invers agonist profil may repres attract strategi treatment sud
|
D043884;D000077285;D019966;D063387
|
T121;T116;T109;T192;T033;T048
|
36,291,127
|
long term igf stimul lead cellular senesc via function interact thioredoxin interact protein txnip growth hormon gh insulin like growth factor igf signal pathway play major role orchestr cellular interact metabol growth age studi worm mice show downregul activ ghigf pathway could benefici extens lifespan laron syndrom ls inherit autosom recess disord caus molecular defect gh receptor ghr gene lead congenit igf defici life long exposur minut endogen igf level ls associ low statur well endocrin metabol deficit epidemiolog survey report patient ls reduc risk develop cancer studi conduct ls deriv lymphoblastoid cell led identif novel link igf thioredoxin interact protein txnip multifunct mitochondri protein txnip high express ls patient play critic role cellular redox regul thioredoxin given igf affect level txnip various stress condit includ high glucos oxid stress hypothes igf txnip axi play essenti role help maintain physiolog balanc cellular homeostasi studi show txnip vital cell fate choic cell challeng various stress signal furthermor prolong igf treatment lead establish prematur senesc phenotyp character uniqu senesc network signatur combin igftxnip induc prematur senesc associ typic secretori inflammatori phenotyp mediat statil signal final mechanist insight might help understand basic aspect igf relat patholog clinic set
|
D002352;D016922;D007334;D046150;D013879
|
T123;T047;T116;T043
|
36,291,126
|
extracellular molecular chaperon clusterin inhibit amyloid fibril format suppress cytotox associ semen deriv enhanc virus infect sevi clusterin glycoprotein present high concentr mani extracellular fluid includ semen increas express accompani disord associ extracellular amyloid fibril accumul alzheim diseas clusterin extracellular molecular chaperon prevent misfold amorph amyloid fibrillar aggreg wide varieti unfold protein semen amyloid fibril form amino acid fragment prostat acid phosphatas term semen deriv enhanc virus infect sevi potenti hiv infect studi clusterin potent inhibit vitro format sevi fibril along dissoci furthermor clusterin reduc toxic sevi pheochromocytoma cell semen clusterin may play import role prevent sevi amyloid fibril format dissoci sevi fibril mitig enhanc hiv infect
|
D000682;D051152;D015658;D015497;D010446;D017027
|
T129;T123;T116;T005;T126;T047
|
36,291,125
|
alzheim diseas patient deriv olfactori stem cell model identifi gene express chang associ cognit earli symptom alzheim diseas ad impair sens smell molecular basi remain elus generat human olfactori neurospher deriv on cell peopl ad mild cognit impair mci perform global rna sequenc determin gene express chang on cell express marker neurogli differenti provid uniqu cellular model explor chang earli ad associ pathway transcriptom data on cell reveal differenti express gene deg associ cognit process ad cell compar mci match healthi control hc kinas anchor protein akap signific alter gene ad compar mci hc link cognit function greatest chang gene express deg occur ad mci gene pathway analysi reveal defect multipl cellular process age intellectu defici altern splice signific dysregul ad on cell result demonstr on cell provid cellular model ad recapitul diseas associ differ reveal potenti novel gene includ akap may role ad particular mci ad transit examin
|
D000544;D003071;D015870;D013234;D009831
|
T025;T024;T045;T081;T047;T041;T048
|
36,291,124
|
compartment cgmp signal induc pluripot stem cell deriv cardiomyocyt prolong cultur therapeut benefit stimul cgmp pathway form treatment combat heart failur well fibrot patholog becom well establish howev develop signal compartment crucial pathway far overlook studi three main cgmp pathway name nitric oxid cgmp natriuret peptid np cgmp adrenoreceptor ar cgmp matur time cultur cardiomyocyt differenti human pluripot stem cell hpsc cms introduc cgmp sensor frster reson energi transfer fret microscopi use select phosphodiesteras pde inhibit reveal cgmp signal compartment hpsc cms various time cultur methyl cyclodextrin employ remov cholesterol thus destroy caveola cell physic cgmp signal compartment known occur adult cardiomyocyt identifi pde regul cgmp np cgmp pathway earli stage cultur late stage role cgmp pathway diminish predomin regul pde pde pde np cgmp pathway show unrestrict local unregul cgmp signal last observ matur ar cgmp pathway prolong cultur hpsc cms depend accumul caveola overal studi highlight import structur develop necessari compartment cgmp pathway matur hpsc cms
|
D006152;D057026;D032383
|
T123;T025;T114
|
36,291,123
|
neuroinflammatorypotenti hiv nefvari modul gene express profil astrocyt hiv mediat neurotox thought associ hiv viral protein activ astrocyt microglia induc inflammatori cytokin lead develop hiv associ neurocognit disord hand current studi observ hiv nef upregul level il ip tnf around fold normal human astrocyt nhas compar cell empti vector control moder downregul express profil inflammatori cytokin observ due rna interfer furthermor determin impact inflammatori cytokin upregul kynurenin pathway metabolit indoleamin dioxygenas ido hydroxyanthranil acid oxygenas haao nha found fold respect addit variat level nitric oxid rna interfer signific upregul cytokin pathway specif metabolit could link neurotox potenti hiv nef thus downregul cytokin kynurenin metabolit observ sirna nef interfer indic possibl combin rna interfer approach current antiretrovir therapi prevent neurotox develop
|
D001253;D015658;D015497;D000090862;D054311
|
T123;T025;T116;T033;T005;T047
|
36,291,122
|
increas preval elev dhea pcos women non classic b c phenotyp retrospect analysi patient age year well known subgroup women pcos present excess adren androgen product general associ ovarian hyperandrogen past imposs correl adren hyperandrogen clinic hormon pattern pcos howev adren androgen strict depend age blood valu reduc patient move twenti thirti due serum dhea valu strong influenc age distribut studi popul avoid bias studi retrospect analyz clinic hormon data pcos women twenti age year data young hyperandrogen women pcos evalu serum dhea increas third studi patient associ higher valu testosteron androstenedion phenotyp patient high dhea higher valu patient normal dhea phenotyp therefor dhea increas general part general higher androgen product subgroup pcos patient independ find anovulatori ovulatori cycl polycyst normal ovari howev studi show import differ pcos phenotyp lower preval increas dhea phenotyp pcos patient general highest androgen level versus non classic b c pcos phenotyp observ also found patient phenotyp pcos present signific lower bmi serum insulin patient normal dhea phenotyp patient b c phenotyp opposit occur conclud adren hyperandrogen common patient non classic b c phenotyp pcos general part general higher product androgen subgroup pcos patient howev factor may increas adren androgen product influenc clinic express syndrom studi larg select age popul pcos women differ phenotyp need
|
D017588;D011085;D061385
|
T121;T047
|
36,291,121
|
tap plant microbiom interact len multi omic techniqu review highlight pivot role root exud rhizospher especi interact plant microb plant plant root exud determin soil nutrient mobil plant nutrit status communic plant root microb root exud contain divers special signal metabolit primari secondari spatial behavior metabolit around root zone strong influenc rhizospher microorgan intim compat interact therebi regul complex biolog ecolog mechan context review current understand biolog phenomenon allelopathi mediat phytotox compound call allelochem releas plant soil affect growth surviv develop ecolog infest intensif plant speci microb natur communiti agricultur system advanc next generat sequenc ngs metagenom metatranscriptom open possibl better understand effect secret metabolit composit activ root associ microbi communiti nevertheless understand role secretori metabolit microbiom manipul assist design next generat microbi inocul target diseas mitig improv plant growth use synthet microbi communiti syncom tool besid discuss differ approach highlight advantag conjug metabolom approach genet design metabolit base genom wide associ studi dissect metabolom divers understand genet compon metabolit accumul recent advanc field metabolom expedit comprehens rapid profil discoveri novel bioactiv compound root exud context discuss expand array metabolom platform metabolom profil integr multivari data analysi crucial explor biosynthesi pathway well regul associ pathway gene transcript protein level final role determin shape rhizomicrobiom
|
D018517;D064307
|
T001;T032;T028;T002
|
36,291,120
|
natur occur bicoumarin compound daphnoretin inhibit growth induc megakaryocyt differenti human chronic myeloid leukemia cell daphnoretin extract stem root wikstroemia indica l ca mey shown possess antivir antitumor activ herein hypothes daphnoretin might induc megakaryocyt differenti therebi inhibit prolifer cell serv differenti therapi agent chronic myeloid leukemia cml daphnoretin treat k hel cell examin growth inhibit cell morpholog megakaryocyt specif marker potenti mechan megakaryocyt differenti daphnoretin treat k cell evalu result show daphnoretin inhibit growth k hel cell dose time depend manner flow cytometri analys reveal daphnoretin treatment slight increas proport sub g polyploid cell compar dimethyl sulfoxid dmso treat control cell morpholog examin show daphnoretin treat k hel cell exhibit enlarg contour multinucl megakaryocyt characterist compar dmso treat control cell daphnoretin treatment also dramat enhanc express megakaryocyt marker cd cd optim megakaryocyt differenti condit daphnoretin increas phosphoryl stat stat summari daphnoretin inhibit cell growth induc megakaryocyt differenti k hel cell efficaci daphnoretin vivo patient cml may need investig valid
|
D007951;D015464
|
T191
|
36,291,119
|
could curdlanwhey protein isolatehydroxyapatit biomateri consid promis bone scaffold fabric character evalu cytocompat toward osteoblast cell vitro number bone fractur crack requir surgic intervent increas everi year henc huge need develop new potenti bone scaffold bone regener goal studi gain knowledg basic properti novel curdlanwhey protein isolatehydroxyapatit biomateri context use bone tissu engin purpos research also determin whether concentr whey protein isol scaffold influenc properti thus two biomateri differ concentr whey protein isol ie wt wt hereaft call curwpihap curwpihap respect fabric subject evalu poros mechan properti swell abil protein releas capac enzymat biodegrad bioactiv cytocompat toward osteoblast vitro found biomateri fulfil number requir bone scaffold demonstr limit swell abil undergo control enzymat biodegrad form apatit layer surfac support viabil growth prolifer differenti osteoblast hand biomateri character low open poros may hinder penetr cell though structur moreov low mechan properti compar natur bone limit use fill bone defect non load bear implant area eg craniofaci area addit support applic mechan strong materi titanium plate thus preliminari vitro research indic biomateri compos curdlan whey protein isol hydroxyapatit seem promis bone tissu engin applic poros mechan properti improv subject work
|
D017886;D001672
|
T121;T122;T197
|
36,291,118
|
melatonin indol acet acid synergist regul plant growth stress resist plant growth develop exhibit plastic plant adapt environment chang stress various phytohormon interact synergist antagonist regul respons melatonin indol acet acid iaa widespread across plant kingdom melatonin import member neuroendocrin immun regulatori network confer autoimmun protect viral invas melatonin function plant growth regul biostimul import role enhanc plant stress toler iaa high complex stress respons mechan particip seri stress induc physiolog chang articl review studi signal pathway melatonin iaa focus specif regulatori mechan discuss hormon coordin plant growth develop stress respons furthermor interact melatonin iaa upstream downstream transcript regul discuss perspect modul plant develop stress adapt review studi suggest low concentr melatonin promot iaa synthesi wherea high level reduc iaa level similar iaa melatonin promot plant growth develop iaa suppress melatonin induc inhibit germin iaa signal play import role plant growth develop wherea melatonin signal play import role stress respons
|
D010937;D008550
|
T125;T121;T116;T109
|
36,291,117
|
effect mutat lipopolysaccharid biosynthesi bacteri fit paper present genom sequenc shigella sonnei mutant strain sonnei effect mutat lipopolysaccharid biosynthesi bacteri fit lipopolysaccharid major compon outer leaflet gram negat outer membran report frameshift mutat gene gmhd genom sonnei mutat result lack epimer core heptos also found increas thermosensit abnorm cell divis increas suscept erythromycin cefalexin compar sonnei compar genom analysi supplement structur data help us understand effect specif mutat virul bacteria may provid opportun studi effect short lipopolysaccharid
|
D008070;D012764;D056084
|
T081;T045;T007;T109
|
36,291,116
|
plasma cell free dna novel biomark diagnosi monitor atherosclerosi atherosclerosi lead caus cardiovascular diseas cvds high rate mortal worldwid plasma cell free dna cfdna main origin apoptosi necrosi activ secret recogn promis biomark diagnosi prognosi multipl cancer wherea report cfdna cvds found increas quantiti decreas integr cfdna cfdi serum patient compar normal control moreov reduc cfdi invers correl serum ldl level carotid plaqu size carotid plaqu thick progress consist vivo experi confirm releas cleavag cfdna increas concomit develop progress apo mice studi shed light potenti cfdna cfdi molecular biomark detect monitor
|
D050197;D000073888
|
T123;T047;T046;T114
|
36,291,115
|
therapeut strategi restor perturb corneal epitheli homeostasi limbal stem cell defici current trend futur direct limbal stem cell constitut import cell popul requir regener corneal epithelium insult limbal stem cell nich suffici sever diseas known limbal stem cell defici occur absenc function limbal stem cell vision compromis conjunctiv corneal epithelium occur lead opacif inflamm neovascular chronic scar limbal stem cell transplant standard treatment unilater case limbal stem cell defici bilater case requir allogen transplant herein review current therapeut util limbal stem cell also describ sever limbal stem cell marker impact phenotyp function discuss possibl modul limbal stem cell sourc stem cell facilit develop novel therapeut intervent final consid sever hurdl widespread adopt propos methodolog discuss overcom realiz vision restor intervent
|
D016850;D003316
|
T023;T047
|
36,291,114
|
articular cartilag regener bioassembl spheric micro cartilag build block articular cartilag lesion preval affect one seven american adult mani young patient cartilag capabl regener exist therapeut approach articular cartilag lesion limit cartilag tissu engin promis approach regener articular neocartilag bioassembl emerg technolog use microtissu micro precursor tissu build block construct macro tissu summar highlight applic bioassembl technolog regener articular cartilag discuss advantag bioassembl present two type build block multipl cellular scaffold free spheroid cell laden polym hydrogel microspher present techniqu generat build block bioassembl method includ bioprint non bioprint techniqu use data set articl last year literatur analyz seven categori relat research year trend present limit futur direct technolog also discuss
|
D002358;D062028
|
T063;T024
|
36,291,113
|
ngf prevent loss trkavegfr cell vegf isoform dysregul retina adult diabet rat among factor involv diabet retinopathi dr nerv growth factor ngf vascular endotheli growth factor vegfa shown affect neuron surviv vascular function suggest crosstalk might influenc dr outcom address question administr eye drop contain ngf ed ngf adult spragu dawley rat receiv streptozotocin stz intraperiton inject use experiment paradigm investig ngf modul vegfa receptor vegfr express show ed ngf treatment prevent histolog vascular alter stz retina vegfr express decreas gcl inl preserv co express vegfr ngf tropomyosin relat kinas trka receptor retin ganglion cell rgcs wb analysi confirm ngf effect vegfr express activ show recoveri vegf isoform dysregul suppress stz induc vegfa express reduct inflammatori pro apoptot intracellular signal also found stzngf retina find suggest ed ngf administr might favor neuroretina protect turn counteract vascular impair regul vegfr andor vegfa isoform express earli stage diseas possibl increas ngf avail might contribut switch proangiogenicapoptot neuroprotect action vegf discuss
|
D003921;D003930;D020932;D009883;D020917;D042461
|
T123;T050;T116;T192;T122;T126;T047
|
36,291,112
|
evalu novel biolog properti diterpen isol plectranthus ornatus codd vitro silico plectranthus ornatus codd genus plectranthus lamiacea famili use tradit medicin africa india australia pharmacolog studi show use plant treat digest problem turn leav use antibiot properti region brazil treat skin infect present studi examin anti inflammatori antioxid cytotox effect haliman labdan diterpen r e acetoxyhalima dien oic acid hal diacetoxi r epoxi labden one plec forskolin like mixtur di acetylforskolin di acetyl deoxyforskolin mrc isol p ornatus lung leukemia ccrf cem cancer cell line normal human retin pigment epitheli arp cell line vitro addit molecular dock comput approach use admet properti analys swissadm protox ii predict result indic test compound signific reduc viabil cancer cell demonstr cytotox effect non neoplast cell line apoptosi indic show increas ros level test ccrf cem cancer cell line treatment furthermor comput studi found hal exhibit moder antioxid activ addit select compound chang mitochondri membran potenti mmp increas dna damag mitochondri copi number ccrf cem cancer cell line also demonstr anti inflammatori effect arp normal cell line upon lipopolysaccharid lps treatment associ modul il il tnf gm csf gene express dock studi gave indic lowest bind energi di acetylforskolin dock il tnf gm csf di acetyl deoxyforskolin dock il admet studi show drug like properti studi compound thus haliman labdan diterpen isol p ornatus appear offer biolog potenti howev research necessari understand interact benefici properti
|
D004224;D031346
|
T002;T109
|
36,291,111
|
combin angelica giga artemisia dracunculus extract prevent dexamethason induc muscl atrophi mice aktmtorfoxoa signal pathway sinc skelet muscl atrophi result various caus acceler progress sever diseas prevent help maintain health qualiti life rang natur materi investig potenti prevent effect muscl atrophi ethanol extract angelica giga artemisia dracunculus concentr dri mix ratio creat mixtur chdt evalu potenti chdt prevent muscl atrophi explor mechan involv chdt oral administ cbl mice daili day dexamethason dex intraperiton inject daili induc muscl atrophi day start oral administr found chdt prevent dex induc reduct muscl strength mass fiber size like upregul aktmtor signal pathway addit chdt reduc dex induc increas serum concentr pro inflammatori cytokin direct induc degrad muscl protein find suggest chdt could serv natur food supplement prevent muscl atrophi
|
D029969;D019306;D009133;D010936
|
T121;T123;T046;T002
|
36,291,110
|
ex vivo integr human stem retin ganglion cell mous retina cell replac therapi may key achiev function recoveri neurodegen optic neuropathi diseas glaucoma one strategi hold promis regard use human embryon stem cell induc pluripot stem deriv retin ganglion cell hrgcs previous hrgc transplant studi shown modest success part due low surviv integr transplant cell host retina field challeng mix assay outcom measur probe determin transplant success thefor devis transplant assay involv hrgcs mous retina explant bypass physic barrier impos retin membran show hrgc neurit soma capabl invad mous explant subset hrgc neurit guid mous rgc axon neonat mous retina explant lesser extent adult explant promot hrgc integr neurit outgrowth use assay test whether suppment cultur brain deriv neurotroph factor bdnf adenyl cyclas activ forskolin enhanc hrgc neurit integr neurit outgrowth integr show supplement cultur combin bdnf forskolin strong favor hrgc integr increas neurit outgrowth complex well invas mous explant transplant assay present practic tool investig strategi test optim integr donor cell host tissu
|
D012160;D012165;D058953
|
T023;T025
|
36,291,109
|
decreas oligodendrocyt number hippocamp subfield ca schizophrenia replic studi hippocampus relat cognit deficit work verbal memori frequent schizophrenia hippocamp volum loss particular cornu ammoni ca subregion shown magnet reson imag studi howev under cellular alter remain elus use unbias design base stereolog report reduct oligodendrocyt number ca schizophrenia granular neuron dentat gyrus dg aim replic find independ sampl use stereolog approach investig number densiti neuron oligodendrocyt astrocyt ca granular neuron dg left right hemispher brain men schizophrenia brain age sex match healthi control schizophrenia decreas number densiti oligodendrocyt detect left right ca wherea mean volum ca dg number densiti neuron astrocyt granular neuron differ patient control even adjust variabl posit correl postmortem interv age result replic previous describ decreas oligodendrocyt bilater ca schizophrenia point deficit oligodendrocyt matur loss matur oligodendrocyt chang result impair myelin neuron decoupl link alter function connect subsequ cognit dysfunct schizophrenia
|
D009836;D012559;D018891
|
T023;T025;T048
|
36,291,108
|
effect cell cycl cell surfac express voltag gate sodium channel na k atpas voltag gate sodium channel vgscs target mani therapi variat membran potenti occur throughout cell cycl yet littl attent devot role vgscs na k atpas hypothes addit doubl dna cell membran anticip cell divis doubl vgscs na k atpas compar non divid cell test hypothesi eight immort cell line correl immunocytofluoresc label vgscs na k atpas propidium iodid dapi fluoresc use flow cytometri imag cell surfac express vgscs phase doubl seen phase g g contrast na k atpas express increas fold increas independ baselin express channel pump variat vgsc na k atpas express implic understand sodium role control cell cycl variabl treatment target compon na handl system
|
D000251;D061566
|
T123;T126;T116
|
36,291,107
|
cytotox genotox bioactiv dental materi promot biolog base treatment strategi restor dentistri paramount import invas treatment avoid maintain tooth vital studi aim assess biocompat commerci avail bioactiv materi use dental pulp cap studi perform monocytemacrophag peripher blood sc cell line atcc crl follow six specif bioactiv materi proroot mta dentspli sirona mta angelus angelus biodentin septodont therac lc bisco activa bioactiv pulpdent predicta bioactiv bulk parkel cytotox investig agent measur use resazurin base cell viabil assay genotox evalu use alkalin comet assay addit flow cytometri fc apoptosi detect conduct fitc fluorescein isothiocyan annexin v apoptosi detect kit fc cell cycl arrest assess carri propidium iodid stain result studi show signific cytotox genotox p gt proroot mta mta angelus biodentin activa bioactiv predicta bioactiv convers therac lc present signific decreas p lt conclus due excel biocompat low cytotox mta biodentin activa bioactiv predicta bioactiv may suitabl pulp cap treatment hand due high cytotox therac lc use avoid vital pulp therapi
|
D057872
|
T122
|
36,291,106
|
chromosom heteromorph cancer suscept revisit chromosom heteromorph chs part genet variat man past literatur larg posit whether chs could correl develop malign possibl seem close end recent data rais question potenti influenc repetit dna element main compon chs cancer suscept new evid potenti role chs cancer found follow observ amplif andor epigenet alter chs routin report tumor ii express ch deriv rna embryon cell stress includ cancer cell iii express part ch dna long noncod rnas plus iv theori suggest possibl applic two hit model euchromat copi number variant cnvs herein point discuss detail lead conclus chs far given suffici consider routin cytogenet analysi eg leukemia lymphoma need attent futur research set includ solid tumor heighten focus may achiev approach standard sequenc chromosom microarray techniqu minimum impair abil detect blind high repetit dna sequenc
|
D012091;D009369
|
T123;T191;T028;T114;T086
|
36,291,105
|
dual immun regulatori role interleukin patholog condit interleukin il member il cytokin famili multifunct cytokin play critic role maintain host homeostasi patholog condit allergi infecti diseas cancer act multipl type immun cell promot type immun respons il rapid releas immun non immun cell upon stimul stress act alarmin bind receptor suppress tumorigen st trigger downstream signal pathway activ inflammatori immun respons recogn il display dual function immun regulatori effect mani diseas pro anti tumorigen effect like depend primari target cell il sst express level cellular context cytokin microenviron herein summar current understand biolog function il role pathogenesi various condit includ inflammatori autoimmun diseas infect cancer case organ transplant emphas natur context depend dual immun regulatori function il mani cell diseas review system studi understand distinct role il differ cell essenti develop effect diagnos therapeut approach il relat diseas
|
D001327;D007375;D000067596;D009369;D007249;D007239
|
T129;T116;T191;T047;T046
|
36,291,104
|
contribut lipotox diabet kidney diseas lipotox fundament pathophysiolog mechan diabet non alcohol fatti liver diseas increas recogn diabet kidney diseas dkd pathogenesi review highlight lipotox pathway podocyt proxim tubul cell arguabl two critic site nephron dkd discuss focus membran transport lipid droplet repres potenti therapeut target well current develop pharmacolog approach reduc renal lipotox
|
D003928;D007687;D026901;D050199;D005227
|
T123;T116;T025;T109;T168;T023;T126;T047
|
36,291,103
|
power gene technolog way creat cell model modern societi face mani biomed challeng requir urgent solut two import includ elucid mechan social signific diseas develop prospect drug treatment diseas experiment cell model conveni tool address mani problem power cell model enhanc combin gene technolog allow examin even subtl chang within structur genom permit test protein nativ environ list possibl recent emerg technolog truli coloss requir rethink number approach obtain experiment cell model review analyz possibl limit promis gene technolog obtain cell model also give recommend develop creation relev model opinion review use novic cell biologist provid refer point rapid grow univers gene cell technolog
|
D000072669;D064113
|
T063;T040
|
36,291,102
|
c terminus psma proteasom subunit preferenti trap intrins disord protein degrad degrad intrins disord protein idp non proteasom process requir proteasom target polyubiquitin howev whether idp recogn non proteasom includ complex remain unknown analys protein interactom dataset reveal proteasom subunit psma preferenti interact mani idp vivo cell free experi reveal c terminus psma amino acid long fragment idp trapper recombin trapper suffici interact mani idp block idp degrad vitro proteasom possibl compet nativ trapper addit third psma trapper bind protein previous identifi proteasom substrat base publish dataset mani trapper bind protein associ intracellular proteasom psma trap idp proteasom substrat uniqu featur previous recogn characterist proteasom substrat vitro propos model wherebi psma c termin region trap subset idp facilit proteasom degrad
|
D064267;D007290
|
T123;T121;T116;T114
|
36,291,101
|
boost neurogenesi adult hippocampus use antidepress mesenchym stem cell hippocampus one privileg region neural stem cell nich brain neural stem cell differenti new neuron throughout adulthood howev dysregul hippocamp neurogenesi age injuri depress neurodegen diseas lead debilit cognit impact debilit symptom deterior qualiti life afflict individu impair hippocamp neurogenesi especi difficult rescu increas age neurodegener howev potenti boost endogen wnt signal influenc pathway modul receptor agonist antagonist drug cell therapi base intervent offer hope restor augment hamper wnt signal facilit increas hippocamp neurogenesi would serv endogen repair mechan contribut hippocamp structur function plastic review focus possibl interact neurogenesi wnt signal control antidepress mesenchym stem cell mscs overcom debilit symptom caus age diseas environment factor stress also address current limit hinder direct extrapol research anim model human applic technic challeng associ mscs cellular product potenti therapeut solut
|
D019636;D059630
|
T047;T025
|
36,291,100
|
bisphenol exposur disrupt cytoskelet organ develop pre implant embryo endocrin disrupt activ bisphenol compound well document less known regard impact cell divis earli embryo format test effect acut vitro exposur bisphenol bpa common substitut bisphenol f bpf critic stage mous pre implant embryo develop includ first mitot divis cell polar well morula blastocyst format time initi cleavag determin live cell imag subsequ divis cytoskelet organ lineag marker label assess high resolut fluoresc microscopi analysi reveal brief cultur bpa bpf imped cell divis disrupt embryo develop stage test surpris bpf detriment earli embryo bpa notabl poor embryo develop associ cytoskelet disrupt actomyosin network apic domain format cell polar actin ring zipper embryo seal alter cell lineag marker profil result underscor bisphenol disrupt cytoskelet integr remodel vital earli embryo develop rais concern regard use bpf safe bpa substitut
|
D001755;D001559;D010636;D003599
|
T026;T018;T121;T109
|
36,291,099
|
glutathion transferas z serv prognost factor glioblastoma promot drug resist antioxid pathway glutathion transferas gst famili detoxif enzym regul malign progress drug resist various tumor hematopoiet prostaglandin synthas hpgds also refer gsts gstz gsta abnorm express multipl cancer role tumorigenesi develop remain unclear studi use bioinformat tool analyz connect hpgds gstz gsta varieti tumor genet databas perform biochem assay gbm cell line investig involv hpgds prolifer drug resist found hpgds gstz gsta abnorm express varieti tumor associ prognos express level hpgds signific posit correl grade glioma high level hpgds predict poor prognosi inhibit hpgds signific downregul gbm prolifer reduc resist temozolomid disrupt cellular redox balanc inhibit activ jnk signal conclus studi suggest hpgds gstz gsta relat progress multipl tumor hpgds expect prognost factor gbm
|
D005909;D005982;D019008
|
T116;T191;T042;T126;T038
|
36,291,098
|
compar cell subset broncho alveolar lavag bal peripher blood patient advanc lung cancer lung cancer lc tissu immunolog character often scarc explor compar cell characterist broncho alveolar lavag tumor affect bal contralater lung cl bal match peripher blood pb
|
D008175;D016176
|
T191;T025
|
36,291,097
|
adipokin regul autophagi obes link cancer excess bodi weight obes becom signific risk factor cancer develop obes adipos tissu alter biolog function deregul secret bioactiv factor hormon cytokin adipokin promot inflammatori microenviron conduc carcinogenesi tumor progress adipokin regul tumor process apoptosi prolifer migrat angiogenesi invas addit found modul autophagi process implic tumor suppress healthi tissu cancer progress establish tumor sinc tumor promot role autophagi well describ process suggest therapeut target cancer howev effect target autophagi might depend tumor type microenvironment condit circul adipokin could influenc role autophagi cancer review recent evid relat role adipokin cancer cell autophagi effort understand tumor respons context obes assumpt autophagi target treatment
|
D054392;D001343;D063646;D009369;D009765
|
T123;T116;T191;T043;T047
|
36,291,096
|
exosom adipos stem cell promot diabet wound heal ehsplrpakt axi oxid damag critic caus diabet wound exosom various stem cell could promot wound repair investig potenti mechan exosom adipos deriv stem cell adsc exo promot diabet wound heal modul oxid stress found adsc exo could promot prolifer migrat angiogenesi keratinocyt fibroblast endotheli cell furthermor adsc exo reduc reactiv oxygen speci ros level cell protect hypox oxid stress damag final local inject adsc exo wound site signific increas collagen deposit neovascular reduc ros level cell death thus led acceler diabet wound closur mechan under adsc exo function involv heat shock protein hsp express cell surfac function could inhibit anti hsp antibodi exosom hsp could bind low densiti lipoprotein receptor relat protein lrp receptor recipi cell membran lead activ downstream akt signal pathway knockdown lrp inhibit akt signal pathway ly fibroblast suffici impair benefici effect adsc exo summari adsc exo signific acceler diabet wound closur exosom hsplrpakt signal pathway
|
D055354;D026503;D051057;D014945;D059630;D000273;D048909;D018841
|
T026;T123;T116;T025;T192;T024;T201;T040;T126;T047
|
36,291,095
|
autoantibodi tumor associ antigen diagnost biomark hispan patient hepatocellular carcinoma tumor associ antigen taa investig mani year potenti earli diagnosi tool especi hepatocellular carcinoma hcc nonetheless studi focus hispan hcc group may associ distinct etiolog risk factor present studi investig novel anti taa autoantibodi diagnost biomark hispan hcc patient
|
D000951;D001323;D014408;D006528;D008113;D000912
|
T121;T129;T123;T116;T191
|
36,291,094
|
febril seizur caus depress anxiogen behavior rat febril seizur fs common type seizur occur human infanc childhood although epilept seizur associ psychiatr disord comorbid diseas depress anxieti autism spectrum disord sleep disord attent deficit cognit impair migrain causal relationship fs psychiatr disord poor understood object current studi investig relationship fs occurr childhood pathogenesi anxieti disord depress use fs rat model induc febril seizur infantil rat day postnat use mercuri vapor lamp week week fs induct examin behavior record local field potenti lfps assess anxieti depress disord interest fs induct infantil rat anxiogen behavior depress like phenotyp found adult juvenil fs rat analysi lfps reveal hz hippocamp theta rhythm neural oscillatori marker anxieti disord signific increas fs rat compar wild type litterm taken togeth find suggest fs occurr infant causal relat increas level anxieti relat behavior depress like symptom juvenil adult rodent
|
D003294;D008628
|
T131;T047;T196
|
36,291,093
|
reduct soce associ aggreg platelet mice platelet specif delet orai calcium signal platelet store oper ca entri soce receptor oper ca entri roce mechan crucial platelet activ function orai protein implic platelet soce studi evalu contribut orai protein process use wash platelet adult mice gender platelet specif delet orai gene orai floxflox pf cre term orai plt ko sinc mice ubiquit orai defici show earli lethal platelet aggreg well ca entri releas measur vitro follow stimul collagen collagen relat peptid crp thromboxan analogu u thrombin adp sarcoendoplasm reticulum ca atpas serca inhibitor thapsigargin respect soce aggreg induc thapsigargin concentr abrog orai defici platelet receptor oper ca entri andor platelet aggreg induc crp u thrombin partial affect orai delet depend gender contrast adp collagen crp induc aggreg compar orai plt ko platelet control cell entir concentr rang result reinforc indispens orai protein soce murin platelet contribut understand role agonist depend signal emphas import analys platelet gender
|
D001792;D002118;D000071740
|
T123;T121;T025;T116;T196
|
36,291,092
|
novel gata variant c termin zinc finger compar platelet phenotyp patient like pathogen variant n termin zinc finger gata transcript factor essenti normal erythropoiesi megakaryocyt differenti germlin gata pathogen variant n termin zinc finger n zf typic associ x link thrombocytopenia platelet dysfunct dyserythropoiet anemia variant c termin zf c zf domain describ normal platelet count alter platelet function main characterist independ perform molecular genet analysi identifi novel hemizyg variant cc gt phi c zf region gata german patient spanish patient character bleed platelet phenotyp patient compar find paramet two german sibl carri like pathogen variant pdn gata n zf domain main differ profound thrombocytopenia brother carri pdn variant compar normal platelet count patient carri phi variant spanish patient occasion develop mild thrombocytopenia function platelet defect affect iib integrin activ granul secret present patient addit mild anemia anisocytosi poikilocytosi observ patient c zf variant data support concept gata variant locat differ zf region lead clinic divers manifest
|
D050982;D013921;D016335;D040181;D014644;D000742
|
T123;T070;T116;T087;T047
|
36,291,091
|
fix fix mainten chromosom end versus repair dna doubl strand break earli work muller mcclintock discov physic end linear chromosom name telomer possess inher abil escap unwarr fusion sinc extens research shown special featur reli special protein structur properti confer ident chromosom end thus allow cell distinguish intrachromosom dna doubl strand break due inabl convent dna replic fulli replic chromosom end downregul telomeras somat human tissu telomer shorten cell divid lose protect capac telomer attrit caus activ dna damag checkpoint lead cell cycl arrest enter cell nondivid state call replic senesc act barrier tumorigenesi howev downregul checkpoint overcom barrier lead genom instabl coupl stabil telomer drive tumorigenesi review focus key experi perform model organ saccharomyc cerevisia uncov mechan protect chromosom end elicit dna damag respons conserv pathway mammal well consequ loss human cancer
|
D053903;D019098;D059506;D059766
|
T045;T049;T126;T116
|
36,291,090
|
nuclear proteom induc leukemia cell differenti studi induc granulocyt differenti help reveal molecular mechan cell matur nuclear proteom repres rich sourc regulatori molecul includ transcript factor tfs import understand molecular perturb earli stage differenti process appli proteom quantit profil use isobar label found content protein alter h respect compar h hl cell nuclear fraction tran retinoid acid atra treatment identifi nuclear protein protein annot protein transcript factor tf activ six tfs rreb srcap ccdc trim brd bud downregul three tfs ewsr eno fus upregul earli time point h atra treatment bioinformat annot indic involv hl nuclear proteom dna damag recognit runx trigger pathway p regul pathway appli schedul multipl reaction monitor use stabl isotop label peptid standard mrmsis found persist increas content follow protein pram cepbp rbpj hic hl cell nuclear fraction atra induc granulocyt differenti case stat casp parp prkdc protein transient increas content observ earli time point h atra treatment obtain data nuclear proteom composit dynam granulocyt differenti could benefici develop new treatment approach leukemia mutat p gene
|
D015473;D009687;D020543;D006098;D002467
|
T026;T123;T116;T025;T191
|
36,291,089
|
effect human decidu dental pulp deriv mesenchym stem cell deriv condit medium metabol huvec osteoblast bmscs studi assess effect human decidu dental pulp deriv mesenchym stem cell deriv condit medium shed cm properti various cell type effect vascular endotheli growth factor vegf shed cm lumin architectur prolif abil angiogen potenti human umbil vein endotheli cell huvec determin also investig effect shed cm prolifer human bone marrow mesenchym stem cell hbmscs mous calvari osteoblast cell mct e well express alp ocn runx protein level alp examin use western blot analysi vegf blockad shed cm suppress prolif abil angiogen potenti huvec indic vegf shed cm contribut angiogenesi cultur hbmscs mct e cell shed cm acceler cell growth enhanc mrna express bone differenti marker addit shed cm enhanc alp protein express hbmscs mtt e cell compar fbs group furthermor shed cm promot metabol huvec mct e cell hbmscs find indic potenti benefit shed cm bone tissu regener
|
D017077;D003782;D061307;D059630;D010006;D014094
|
T023;T130;T025
|
36,291,088
|
echinococcus granulosus protoscolec deriv exosom like vesicl egr mir p promot dendrit cell matur differenti cystic echinococcosi major parasit diseas caus echinococcus granulosus serious threaten human health excretori secretori es product e granulosus induc immun toler dendrit cell dcs downregul host immun respons howev effect exosom es product dcs remain unclear studi show e granulosus protoscolec deriv exosom like vesicl psc elv could intern bone marrow deriv dendrit cell bmdcs allow deliveri parasit microrna bmdcs moreov psc elv induc bmdcs produc proinflammatori cytokinesinterleukin il il il tumor necrosi factor alpha tnf interferon gamma ifn psc elv also upregul bmdcs surfac marker major histocompat complex class ii mhc ii well costimulatori molecul cd cd cd psc elv deriv egr mir p upregul il il tnf mrna level bmdcs moreov egr mir p direct target nfkb encod nuclear factor kappa b signific suppress mrna protein level nf b bmdcs express nf b p signific increas suggest egr mir p induc product proinflammatori cytokin modif nf kb pp ratio bmdcs result demonstr psc elv egr mir p might enhanc dcs matur differenti cross speci manner turn may modul host immun respons offer new approach echinococcosi prevent treatment
|
D003713;D048209;D055354;D035683;D004443
|
T026;T123;T025;T204;T114;T047
|
36,291,087
|
target inhibit matrix metalloproteinas prevent aortic dissect murin model aortic dissect ad lethal aortic patholog without effect medic treatment sinc under patholog mechan respons ad remain elus matrix metalloproteinas mmp previous identifi key player atherosclerosi arteri remodel howev function role mmp ad remain larg unknown report increas level mmp observ aminopropionitril fumar bapn induc murin ad ad incid aortic elastin fragment mark reduc mmp knockout mice import pharmacolog inhibit mmp signific reduc ad incid aortic elastin fragment observ less inflammatori cell accumul lower level aortic inflamm decreas smooth muscl cell smc apoptosi mmp knockout mice line previous observ mmp cleav ang generat ang ii bapn treat mmp knockout mice increas level ang decreas level ang ii lower blood pressur addit observ decreas express level vascular cell adhes molecul vcam reduc level reactiv oxygen speci ros mmp knockout aorta mechanist data show ang iivcam signal axi respons mmp mediat inflammatori cell invas transendotheli migrat mmp mediat smc inflamm apoptosi attribut ang iiro signal final observ higher level aortic serum mmp patient ad therefor provid new insight molecular mechan under ad identifi mmp potenti therapeut target life threaten aortic diseas
|
D000784;D020784
|
T047;T046;T126;T116
|
36,291,086
|
activ stabil panx channel astrocyt neuroblastoma cell enhanc cholesterol deplet pannexin panx express neuron glia form atp permeabl channel activ patholog condit epilepsi migrain inflamm ischemia membran lipid composit affect proper distribut function receptor ion channel defect cholesterol metabol associ neurolog diseas order understand impact membran cholesterol distribut function panx neural cell use fluoresc recoveri photobleach frap evalu mobil electrophysiolog dye uptak assess channel function observ cholesterol extract use methyl cyclodextrin inhibit synthesi lovastatin decreas later diffus panx plasma membran panx channel activ dye uptak atp releas ionic current enhanc cholesterol deplet panx transfect cell wild type astrocyt compar non deplet panx null cell manipul cholesterol level may therefor offer novel strategi panx channel activ might modul various patholog condit
|
D001253;D002784;D017630;D009419;D009447
|
T123;T121;T116;T025;T109;T191
|
36,291,085
|
map proteom lipidom chang earli onset non alcohol fatti liver diseas use hepat spheroid non alcohol fatti liver diseas affect one fourth world popul central diseas progress lipid accumul liver follow inflamm fibrosi cirrhosi under mechan behind earli stage diseas poor understood expos human hepat hepgca cell base spheroid oleic acid palmit acid employ proteom lipidom analysi investig effect hepatocyt treatment success induc vivo hallmark nafld evidenc intracellular lipid accumul increas atp level quantit lipidom analysi reveal increas ceramid lpc satur triglycerid decreas ratio pcpe similar chang observ patient liver biopsi proteom analysi combin qpcr show increas epitheli mesenchym transit emt signal activ emt valid transcriptom tgf treat spheroid increas mesenchym cell marker n cadherin collagen express found studi demonstr model system thus close echo sever clinic featur non alcohol fatti liver diseas use investig under molecular chang occur condit
|
D000081362;D065626
|
T047;T091;T109
|
36,291,084
|
novel epigenet modul chitosan base scaffold promis bone regen materi bone tissu engin complic field requir concert particip cell scaffold osteoact molecul replac damag bone studi synthes chitosan base cs scaffold incorpor trichostatin tsa epigenet modifi molecul achiev promis bone regener potenti scaffold various biphas calcium phosphat bcp proport fabric addit bcp improv scaffold mechan properti delay degrad rate wherea bcp scaffold match appropri scaffold requir proper concentr tsa also valid develop scaffold releas tsa sustain three day scaffold nm tsa show excel biocompat induc robust osteoblast relat gene express primari human periodont ligament cell hpdlcs evalu vivo bone regener potenti scaffold implant mice calvari defect model excel bone regener abil demonstr micro ct histolog section compar negat control commerci bone graft product new bone form csbcptsa group reveal trabecula like characterist matur bone earli six week csbcptsa scaffold come candid bone tissu engin scaffold
|
D048271
|
T121;T109
|
36,291,083
|
clinic implic covid presenc csf systemat review case report systemat review focus sever acut respiratori syndrom coronavirus sar cov patient detect sar cov virus cerebrospin fluid csf systemat literatur search carri pubm embas scopus web scienc medrxiv biorxiv databas incept decemb case report case seri involv patient prove sar cov presenc csf polymer chain reaction includ search strategi produc articl document total patient posit sar cov csf fever common symptom follow headach cough vomitingnausea major case includ enceph confirm magnet reson imag second preval present mening cerebr spinal fluid analysi found dispar protein level normal glucos level case studi demonstr sar cov enter nervous system via various rout caus cns infect symptom sar cov shown infect cns even respiratori symptom present nasopharyng swab negat result sar cov consid possibl caus cns infect test csf
|
D000086382
|
T047;T067
|
36,291,082
|
ppar partial agonist diseas fate decis special refer cancer peroxisom prolifer activ receptor ppar emerg one extens studi transcript factor sinc discoveri highlight import etiolog treatment numer diseas involv various type cancer type diabet mellitus autoimmun dermatolog cardiovascular disord ligand regard key determin tissu specif activ ppar howev mechan govern process mere contradictori debat yet systemat research either receptor get weak activ endogen natur ligand lead direct activ process synthet ligand serv complet full agonist therefor fine tune action ppar subtl modul reward approach might open new avenu treatment sever diseas recent era research sought develop safer partial ppar agonist order dodg toxic induc full agonist akin balanc activ particular refer cancer review concentr therapeut role partial agonist especi cancer treatment addit time examin efficaci various diseas fate decis also discuss
|
D009369;D047495
|
T191;T116;T192
|
36,291,081
|
metabolom aspect conserv resist relat element respons fusarium culmorum grass famili fusarium head blight fhb serious fungal diseas affect crop plant caus substanti yield reduct product mycotoxin infect grain achiev progress breed crop increas resist maintain high yield possibl without thorough examin molecular basi plant immun respons
|
D005670;D001467;D058431;D009183;D011166
|
T123;T109;T168;T131;T004;T002
|
36,291,080
|
anticoagul short histori mechan action pharmacolog indic anticoagul drug antagon coagul use prevent cure recurr venous thromboembol vte drug prevent clot use centuri nowaday physician possess broad panel multipl anticoagul meet individu need patient within review aim revis histori differ anticoagul current prescrib clinic addit compar pharmacolog properti medic indic difficulti implement new anticoagul vulner patient popul sinc introduct unfraction heparin major advanc mechanist understand medic use anticoagul allow signific improv treat vte patient howev new generat anticoagul current test clinic trial goal optim medic care
|
D000925;D054556
|
T121;T047
|
36,291,079
|
relev dna methyl histon modif periodont scope review background periodont chronic inflammatori diseas involv interplay bacteria inflamm host respons gene environment factor manifest epigenet factor periodont pathogenesi periodont inflamm still well understood limit review histon modif periodont manag scope review aim evalu current evid global specif dna methyl histon modif periodont discuss gap implic futur research clinic practic method scope literatur search three electron databas perform scopus medlin pubm embas epigenet periodont emerg research field scope review conduct identifi extent studi avail describ overal context applic result result overal studi evalu find confirm epigenet chang periodont compris specif modif dna methyl pattern histon protein modif either dampen promot inflammatori respons bacteri challeng conclus plastic epigenet modif implic futur develop target epi drug diagnost tool periodont advanc could invalu earli detect monitor suscept individu
|
D019175;D010518
|
T047;T044
|
36,291,078
|
novel approach non melanoma skin cancer focus hedgehog pathway basal cell carcinoma bcc basal cell carcinoma bcc one common neoplasm popul good prognosi main non aggress develop made underdiagnos exclud statist due avail effici surgic therapi bcc sometim overlook search novel therapi clinician unawar complic pathogenesi avail effect target therapi base hedgehog inhibitor hhi use advanc metastat case nevertheless concomit esthet burden neoplasm sever cancer pathogenesi multifactori complic network depend although tumour microenviron tme genet aberr risk factor seem crucial skin cancer bcc becom access therapeut prevent target result review indic central role develop bcc play hedgehog hh signal pathway two signal molecul identifi main culprit name patch homologu ptch less often smoothen homologu smo consid effect immunotherapi neoplast growth introduc implement immunotherapi advanc bcc pivot benefici us food drug administr fda approv two inhibitor smo treatment advanc bcc sonidegib vismodegib regist base efficaci clinic trial howev despit success limit might occur therapi patient show resist molecul review aim summar novel option target therapi bcc debat mechan clinic implic tumor resist
|
D000970;D002280;D053823;D012878;D000072086
|
T121;T123;T116;T109;T192;T191
|
36,291,077
|
molecular defens respons pine tree pinus spp parasit nematod bursaphelenchus xylophilus pine wilt diseas pwd sever environment problem eastern asia western europ devast larg forest area caus signific econom loss diseas caus pine wood nematod pwn bursaphelenchus xylophilus parasit migratori nematod infect stem conif tree review current known molecular defens respons pine tree infect pwn focus common respons differ speci give particular emphasi resist mechan report select varieti famili identifi share gene pathway associ resist includ activ oxid stress respons cell wall lignif biosynthesi terpenoid phenylpropanoid role post transcript regul small rnas pine respons pwn infect also discuss well possibl implement innov rna interfer technolog focus tran kingdom small rnas final defens respons induc elicitor appli pine plant pwn infect prompt resist review perspect impact find futur research approach discuss
|
D028223;D017187
|
T204;T002
|
36,291,076
|
effect heat shock myogen differenti human skelet muscl deriv mesenchym stemstrom cell muscl injuri degen diseas lesion negat affect function human skeletomuscular system thus qualiti life therefor investig molecular mechan stimul myogen differenti primari skelet muscl deriv mesenchym stemstrom cell sm mscs actual need aim present studi investig myogen differenti cd neural cell adhes molecul ncam posit negat sm mscs respons non cytotox heat stimulus sm mscs isol post oper muscl tissu sort flow cytomet accord cd biomark morpholog surfac profil prolifer myogen differenti investig data show cd cell smaller size better prolifer signific higher level cd mcam cd cdcp compar cd cell control level cd cell signific express myogen differenti marker myod myogenin myog better differenti myogen direct non cytotox heat stimulus signific stronger stimul express myogen marker cd cd cell correl multinucl cell format data show regen properti cd sm mscs stimul extracellular stimulus use promis skelet muscl regener tool vivo
|
D011788;D059630
|
T078;T025
|
36,291,075
|
hematopoiet cell influenc vascular develop retina hematopoiet cell play crucial role adult retina health diseas monocyt macrophag microglia myeloid angiogen cell mac implic retin patholog howev role hematopoiet cell play retin develop understudi tempor chang recruit hematopoiet cell develop retina phenotyp recruit cell well understood studi use hematopoiet cell specif protein vav track investig hematopoiet cell develop retina flow cytometri immunohistochemistri show hematopoiet cell present retina earli p includ microglia monocyt mac even format retin blood vessel hematopoiet cell local inner retina eventu form network intim associ develop vasculatur loss vav lead reduct densiti medium size vessel increas inflammatori respons retin astrocyt pup subject oxygen induc retinopathi hematopoiet cell maintain close associ vasculatur occasion form framework generat new vessel studi provid evid underappreci role hematopoiet cell retin vasculogenesi format healthi retina
|
D012160;D012171
|
T023
|
36,291,074
|
effect pex mutat hear lipid content inner ear peroxisom biogenesi disord due pex gene mutat associ symptom rang sever lead earli childhood death common featur hear impair studi mice carri pex mutat found show normal auditori develop follow earli onset progress increas auditori respons threshold structur defect detect cochlea four week old disrupt synaps inner hair cell condit approach use establish pex express requir local within cochlea normal hear rather hear loss due system effect lipidom analysi inner ear reveal local reduct plasmalogen pex mous mutant compar system plasmalogen reduct report human peroxisom biogenesi disord thus mice pex mutat may use tool understand physiolog basi peroxisom biogenesi disord
|
D007758;D034381
|
T033;T023;T047
|
36,291,073
|
prolifer cell nuclear antigen pcna transcript variant potenti relaps marker b cell acut lymphoblast leukemia leukemia common childhood malign mexico repres childhood cancer although treatment lead surviv develop countri countri less addit patient relaps poor prognosi altern splice play import role transcriptom divers cellular biolog mechan promot increas assort protein potenti distinct function singl gene prolifer cell nuclear antigen pcna gene encod two transcript protein amino acid associ sever import cellular process sever type cancer howev divers transcript variant express condit clear use microarray gene express identifi chang exon express level pcna data valid use rt pcr sanger sequenc three addit transcript pcnav pcnav pcnav identifi comput analys use determin potenti protein result structur interact pcna nativ protein addit pcna transcript variant inhibit use specif sirna determin inhibit contribut malign characterist vitro final quantifi pcna transcript variant acut lymphoblast leukemia sampl identifi express diseas base clinic characterist determin pcnav pcnav express signific low level relaps b patient conclud low express pcnav pcnav could potenti molecular marker relaps acut lymphoblast leukemia patient
|
D054198;D002051
|
T191
|
36,291,072
|
character stem optim purif method human dental pulp stem cell approach standard human dental pulp stem cell hdpscs promis oralcraniofaci regener purif character yet standard hdpscs three donor purifi magnet activ cell sort mac assist stro posit cell enrich coloni deriv c combin c immunophenotyp clonogen stem marker express senesc prolifer analyz multilineag differenti assess qpcr immunohistochemistri extracellular matrix miner confirm credibl result repeat measur analysi post hoc p valu adjust appli hdpsc fraction express stro similar sever surfac marker clonogen express cd vari purif method cell prolifer signific faster c c show highest increas metabol activ coloni format effici cell also exhibit lowest cellular senesc hdpscs produc miner extracellular matrix regard osteogen induct c reveal signific increas mrna express cola cola osteogen marker gene detect vari level c popul miss bdnf gene transcript increas neurogen induct hdpscs abl differenti chondrocyt summari three hdpscs popul show differ phenotyp stem prolifer differenti capac data suggest stro posit cell enrich optim choic hdpscs purif maintain hdpscs stem furthermor immuno phenotyp character minimum requir qualiti control hdpscs studi
|
D013234;D019208
|
T081;T123;T116;T025
|
36,291,071
|
analysi composit featur codon usag pattern gene involv human autophagi autophagi play intric role paradigmat human patholog cancer neurodegen cardiovascular autoimmun disord autophagi regul perform set autophagi relat atg gene first recogn yeast genom subsequ identifi speci includ human sever gene identifi involv process autophagi either direct indirect studi codon usag bias cub gene crucial understand genom biolog molecular evolut examin usag pattern nucleotid synonym codon influenc evolutionari forc gene involv human autophagi code sequenc cds protein code human autophagi gene retriev ncbi nucleotid databas analyz use various web tool softwar understand nucleotid composit codon usag pattern effect number codon enc gene involv human autophagi rang mean valu indic overal low cub nucleotid composit analysi autophagi gene reveal gene margin rich gc content signific influenc codon usag pattern relat synonym codon usag rscu reveal repres repres codon natur select mutat pressur key forc influenc codon usag pattern gene involv human autophagi
|
D001343;D000081183;D012641
|
T045;T070;T043
|
36,291,070
|
parp involv rna polymeras ii elong paus releas regul integr super elong complex rna polymeras elong along gene bodi tight regul ensur proper transcript altern splice event understand mechan factor critic regul rate rna polymeras ii elong process clear import recent show parp well known dna repair protein bound chromatin regul rna polymeras ii elong howev mechan known current studi aim teas parp regul rnapii elong show vivo vitro parp bind direct integr subunit int member elong integr complex associ two protein mediat via c termin domain parp c termin domain int interest occup int along two parp target gene mimick parp suggest role recruitmentassembl elong factor inde knockdown parp result differenti chromatin associ gene occup int key elong factor parp mediat effect due physic presenc parp rather paryl activ studi argu parp control progress rnapii elong complex summari present platform begin deciph parp role recruitingscaffold elong factor along gene bodi region rna polymeras ii elong gene regul
|
D012319;D014158
|
T045;T126;T116
|
36,291,069
|
biomark target therapi non small cell lung cancer current status perspect non small cell lung cancer nsclc one common malign lead caus cancer relat death worldwid despit mani therapeut advanc past decad nsclc remain incur diseas major patient molecular target therapi immunotherapi signific improv prognosi nsclc howev vast major advanc nsclc develop resist current therapi eventu progress review discuss current potenti therapi nsclc focus target therapi immunotherapi highlight futur role metabol therapi combin therapi nsclc
|
D002289;D008175
|
T191
|
36,291,068
|
amyloidogenesi neurotroph dysfunct alzheim diseas common regul pathway amyloid cascad hypothesi predomin use describ pathogenesi alzheim diseas ad decad oligom thought prime caus ad meanwhil neurotroph factor hypothesi also propos decad accumul evid state amyloidogen process neurotroph dysfunct mutual influenc may coincid caus onset progress ad meanwhil intracellular regul particip amyloidogen process neurotroph pathway might common origin caus amyloidogenesi neurotroph dysfunct review current understand regard role neurotroph dysfunct amyloidogen process ad patholog briefli summar mutual influenc two pathogenesi pathway potenti common causal pathway discuss therapeut strategi target common pathway simultan prevent amyloidogenesi neurotroph dysfunct might anticip diseas modifi treatment ad
|
D000544
|
T047;T048
|
36,291,067
|
dietari intervent salmon silver carp phospholipid mice metabol syndrom base lipidom number metabol syndrom met increas fish phospholipid diet reduc risk met studi chang lipid metabol colon content analyz extens lipidom mice metabol syndrom fish phospholipid diet mice random divid experiment group differ diet type establish met model week mice sacrif serum colon content collect ultra high liquid phase tandem mass spectrometri use broad target lipidom analysi qualit quantit detect lipid metabol chang colon content mice intervent fish phospholipid met mice signific inhibit serum total cholesterol tc triglycerid tg decreas serum high densiti lipoprotein hdl c low densiti lipoprotein ldl c level improv fast blood glucos insulin level decreas inflammatori factor decreas screen found thirti three lipid metabolit may key metabolit five signific chang metabol pathway modular lipid metabolit possibl understand extent differ type concentr fish phospholipid affect metabol syndrom therefor studi may provid new therapeut clue improv met
|
D024821;D002347;D061385
|
T121;T047;T013
|
36,291,066
|
heparanas novel therapeut target treatment atherosclerosi cardiovascular diseas cvd lead caus death disabl worldwid manag place huge burden healthcar system hospitalis treatment atherosclerosi chronic inflammatori diseas arteri wall result format lipid rich fibrot plaqu subendothelium key contributor develop cvd detail understand mechan involv develop atherosclerosi urgent requir effect diseas treatment prevent strategi heparanas mammalian enzym known cleav heparan sulfat heparan sulfat proteoglycan key compon extracellular matrix basement membran cleav heparan sulfat heparanas contribut regul numer physiolog patholog process wound heal inflamm tumour angiogenesi cell migrat recent evid suggest multifactori role heparanas atherosclerosi promot under inflammatori process give rise plaqu format well regul lesion stabil review provid date overview role heparanas physiolog patholog process focus emerg role enzym atherosclerosi
|
D050197;D058226
|
T047;T046;T020;T031
|
36,291,065
|
overexpress acd petunia hybrida improv flower longev cadmium stress toler reduc ethylen product floral veget tissu role acd encod aminocyclopropan carboxyl acid acc deaminas enzym extend flower longev improv toler cadmium cd stress assess use transgen petunia hybrida cv mirag rose overexpress acd wild type wt plant overexpress acd reduc ethylen product floral tissu via suppress ethylen relat gene improv flower longev approxim day longer wt flower cd stress acd signific reduc cd induc ethylen product veget tissu transgen plant suppress ethylen relat gene result lower accumul ethylen induc reactiv oxygen speci ros transgen plant wt plant addit express gene involv activ antioxid prolin synthesi well metal chelat process also higher former latter moreov cd accumul signific higher wt plant transgen plant result link greater toler transgen plant cd stress wt plant determin base plant growth physiolog perform result highlight potenti applic use acd extend flower longev ornament bed plant also reveal mechan acd improv cd stress toler suggest acd overexpress plant extend flower longev also help reduc negat impact cd induc ethylen plant growth plant unavoid cultiv cd contamin soil
|
D002104;D032306
|
T131;T196;T002
|
36,291,064
|
evalu tissu express vaspin serum vaspin concentr prognost risk factor endometri cancer adipos tissu multifunct endocrin organ one biolog activ substanc vaspin part serpin famili purpos follow studi determin possibl use vaspin prognost risk factor endometri cancer studi includ patient abnorm uterin bleed determin valu adipokin studi use kaplan meier curv estim patient surviv univari multivari analys perform simultan use cox regress model tissu express vaspin assess patient studi group endometri cancer control group non cancer found higher level vaspin found obes peopl lower stage figo ii lower grade g lvsi metastas lymph node metastas higher serum vaspin level independ protect factor endometri cancer conclud endometri cancer patient serum vaspin concentr median longer dfs compar patient concentr median consid multivari analysi vaspin concentr median independ favour prognost factor endometri cancer tissu express vaspin histolog marker distinguish cancer non cancer lesion differ grade level
|
D016889;D015843;D000273
|
T121;T123;T116;T024;T201;T191
|
36,291,063
|
fetal myocardi express glut role bpa exposur cord blood exosom rat model dietari exposur bisphenol bpa industri chemic present food contain affect nutrient metabol myocardium offspr intrauterin life use murin model observ fetal heart mother expos bpa gkgday day mate gestat decreas express glucos transport glut princip sugar transport fetal heart increas express fatti acid cluster differenti transport cd compar control fetus vehicl treat mother confirm suppress glut expos fetal heart organotyp cultur bpa nm h detect chang cd compar control pregnanc placenta continu releas extracellular vesicl exosom fetal circul vesicl influenc growth develop fetal organ fetal heart cultur treat cord blood deriv exosom isol bpa fed anim glut express increas approxim base result specul exosom cord blood particular placenta deriv nanovesicl could contribut stabil fetal heart metabol amelior harm effect bpa glut express
|
D055354;D005312;D051272;D009206;D001559;D010636
|
T026;T123;T121;T116;T024;T109;T031
|
36,291,062
|
effici gene express human stem cell deriv cortic organoid use adeno associ virus cortic organoid structur deriv either human embryon stem cell human induc pluripot stem cell use explod recent year due abil better recapitul human brain vivo respect organ differenti polar adeno associ virus aav emerg recent year vector choic cns target gene therapi compar use aav mode gene express cortic organoid tradit method lipofectamin electropor demonstr eas use generat quick diseas model express differ variant central gene tdp implic amyotroph later sclerosi frontotempor dementia
|
D057026;D009940
|
T025;T024
|
36,291,061
|
distinct mechan target search endonucleas viii like dna glycosylas protein recogn specif dna sequenc structur element often find cognat dna lesion process mode enzym bind dna non specif slide along dna contour one dimension diffus opposit process mechan distribut search enzym bind sampl releas dna without signific later movement mani dna glycosylas repair enzym excis damag base dna use process search find cognat lesion use method base correl cleavag multipli damag oligonucleotid substrat investig mechan lesion search three structur relat dna glycosylas bacteri endonucleas viii nei mammalian homolog neil neil similar anoth homolog enzym bacteri formamidopyrimidin dna glycosylas neil seem use process mode locat target howev process nei notabl lower neil exhibit almost fulli distribut action type substrat although one dimension diffus often regard univers search mechan result indic even protein share common fold may quit differ way locat target dna
|
D043224;D045647
|
T126;T116
|
36,291,060
|
role n methyladenosin modif microvascular dysfunct microvascular dysfunct mvd long plagu medic field despit improv prevent diagnosi intervent microvascular lesion mvd increas age lead impair microcircul target organ dysfunct mass microvascular complic thus contribut heavi medic burden rise disabl rate date understand molecular mechan under mvd facilit discoveri effect therapeut strategi recent advanc epigenet reveal rna methyl epigenet modif pivot role vascular event n methyl adenosin modif preval intern rna modif eukaryot cell regul vascular transcript splice degrad translat well transloc thus maintain microvascular homeostasi convers disrupt regulatori network lead mvd herein provid review discuss methyl interact mvd also focus alter regulatori network patholog condit final highlight valu regul prognost biomark novel therapeut target might promis addit clinic medicin
|
D000241
|
T123;T121;T114;T109
|
36,291,059
|
pfn inhibit myogenesi bovin myoblast cell via cdc pakjnk myoblast differenti essenti format skelet muscl myofib profilin pfn identifi actin associ protein shown critic import cellular function previous studi found pfn may inhibit differenti bovin skelet muscl satellit cell under mechan known confirm pfn negat regul myogen differenti bovin skelet muscl satellit cell immunoprecipit assay combin mass spectrometri show cdc bind protein pfn cdc could activ pfn could inhibit myogen differenti like pfn mechanist activ cdc increas phosphoryl level pl activ kinas pak activ phosphoryl activ c jun n termin kinas jnk wherea pak jnk inhibitor myogen differenti taken togeth result reveal pfn repressor bovin myogen differenti provid regulatori mechan
|
D000199;D032496
|
T123;T116;T025
|
36,291,058
|
identifi candid circul rna marker coronari arteri diseas deep rna sequenc human plasma advanc rna sequenc rna seq facilit transcriptom analysi plasma discoveri new diagnost prognost marker diseas aim develop short read rna seq protocol detect mrnas long non code rnas lncrnas circular rnas circrna plasma discoveri novel marker coronari arteri diseas cad heart failur hf circul cell free rna patient stabl cad half develop hf within year control sequenc median depth pair read per sampl identifi fragment messeng rnas mrnas long non code rnas lncrnas putat novel lncrnas circular rnas plasma circul level mrnas lncrnas putat novel lncrnas alter patient compar control absolut fold chang gt p lt adjust multipl comparison differenti abund transcript enrich mrnas encod mitochondri genom detect differ plasma rna profil patient develop hf compar summari show mrnas lncrnas circular rnas reliabl detect plasma deep rna seq multipl code non code transcript alter associ cad includ sever mitochondri mrnas may indic under myocardi ischaemia oxid stress valid circul level transcript could potenti use help identifi asymptomat individu establish cad prior acut coronari event
|
D062085;D003324;D000073888
|
T123;T047;T114
|
36,291,057
|
immunolog insight cigarett smoke induc cardiovascular diseas risk smoke one promin addict modern world one lead prevent caus death worldwid although number tobacco smoker believ histor low electron cigarett use dramat rise past decad use replac cigarett smoke electron cigarett thought reduc negat effect burn tobacco nonetheless deliveri nicotin electron cigarett promin compon cigarett smoke cs still deliv negat outcom albeit lesser extent cs smoke shown affect structur function aspect major organ includ lung vasculatur although deleteri effect smoke organ individu well known like advers effect smoke organ long last effect cardiovascular system addit smoke shown play independ role homeostasi immun system lead major sequela adapt innat immun system explor regard cs demonstr alter way promot inflammatori signal lead increas autoimmun diseas inflammatori diseas cancer although mechan action cs fulli understood diseas pathway explor branch immun system pathophysiolog alter immun system smoke correl cardiovascular diseas fulli understood highlight import patholog mechan involv cigarett smoke mani compon cardiovascular diseas immun system order better understand mechan play
|
D066300;D000073865;D002318
|
T055;T047;T073
|
36,291,056
|
approach toward elucid metabol program hematopoiet stemprogenitor cell hematopoiet stem cell hscs bone marrow continu suppli larg number blood cell throughout life collabor hematopoiet progenitor cell hpcs hscs hpcs thought regul util intracellular metabol program obtain metabolit adenosin triphosph atp necessari various cellular function metabolit provid stemprogenitor cell nutrient atp build block generat also util protein modif epigenet regul maintain cellular characterist recent year metabol program tissu stemprogenitor cell under molecular mechan elucid use varieti metabol analysi method review first present advantag disadvantag current approach applic metabol analysi tissu stemprogenitor cell includ hscs hpcs second half discuss characterist regulatori mechan hsc metabol includ decoupl atp product glycolysi mitochondria technolog find potenti advanc stem cell biolog engin metabol perspect establish therapeut approach
|
D044127;D006412
|
T045;T025
|
36,291,055
|
shikonin inhibit fin regener zebrafish larva shikonin naphthoquinon compound extract chines comfrey treat cancer howev report research vertebr tissu regener zebrafish ideal model studi organ regener studi found dpf zebrafish larva expos shikonin concentr mgl show increas inhibit regener tail fin immunohistochem stain show shikonin exposur hpa increas number apoptot cell caudal fin wound larva decreas number prolifer cell shikonin exposur found regul oxid stress increas ros level reduc neutrophil recruit earli stage wound repair moreov shikonin exposur caus disord express fin regener blastem relat gene use astaxanthin regul oxid stress found signific reduc inhibit caudal fin regener mix exposur ampk inhibitor fulleren c shikonin also show similar rescu effect collect studi show shikonin inhibit fin regener zebrafish larva upregul oxid stress level ampk signal pathway research provid valuabl inform mechan action shikonin safe applic
|
D037741;D009285
|
T104;T109
|
36,291,054
|
retino acid receptor alpha rar macrophag protect diet induc atherosclerosi mice retino acid signal play import role regul lipid metabol inflamm howev role retino acid receptor alpha rar atherosclerosi remain determin current studi investig role macrophag rar develop atherosclerosi macrophag isol myeloid specif rar rarmac mice show increas lipid accumul inflamm reduc cholesterol efflux compar rarflfl control mice tran retino acid atra induc atp bind cassett subfamili member abca abcg express cholesterol efflux rarmac mice rarflfl mice ldlr mice myeloid ablat rar signific reduc macrophag abca abcg express cholesterol efflux induc inflammatori gene aggrav western diet induc atherosclerosi data demonstr macrophag rar protect atherosclerosi like via induc cholesterol efflux inhibit inflamm
|
D050197;D002784;D008264;D000072482;D066273
|
T121;T123;T025;T116;T109;T192;T033;T047;T046
|
36,291,053
|
high presenc netot cell neutrophil extracellular trap vagin discharg women vagin exploratori studi infecti vagin microbiolog syndrom great import public health affect million women worldwid howev studi explor phenomenon product neutrophil extracellular trap net releas femal reproduct tract patholog studi aim determin presenc netosi vagin discharg women bacteri vaginosi candidiasi trichomoniasi character net extracellular dna neutrophil elastas citrullin histon identifi confirm net compon n concentr phenotyp net number netot cell determin result show increas netot cell women candida albican ca trichomona vaginali tv increas net tv induc vagin sampl ca tv infect women show differ net phenotyp diff net spr net agg net diff net found high concentr sampl ca increas three type net tv infect sampl intermedi microbiota bacteri vaginosi show increas netot cell intermedi microbiota present higher concentr net therefor alter microbiota presenc fungal parasit infect import stimuli activ induct netosi cytotox effect could enhanc tissu damag
|
D016585;D002181;D065206;D014247;D014246;D019522
|
T026;T047;T033;T204
|
36,291,052
|
activ ppar amelior cardiac fibrosi dsg defici arrhythmogen cardiomyopathi arrhythmogen cardiomyopathi acm genet heart muscl diseas character progress fibro fatti replac cardiac myocyt exist therapeut modal acm most palliat acm caus mutat gene encod desmosom protein includ desmoglein dsg current studi cardiac fibrosi acm under mechan investig use cardiac specif knockout dsg mous model
|
D051301;D047493;D019571;D009206
|
T123;T116;T024;T192;T019;T047
|
36,291,051
|
lack retinoblastoma protein shift tumor metabol glycolysi oxpho allow use altern fuel mutat rb locus lead loss function rb protein caus intraocular tumor uniqu affect children worldwid tumor demonstr rapid prolifer recent shown associ alter metabol signatur found retinoblastoma tumor vitro model lack hexokinas hk exhibit elev fatti acid oxid show ectop express rb induc hk protein rb null cell rb hk mediat metabol switch oxpho glycolysi increas pyruv level reduc atp product reduc mitochondri mass cell lack rb hk flexibl util glutamin fatti acid enhanc oxid phosphoryl depend atp generat reveal metabol biochem assay thus loss rb hk retinoblastoma reprogram tumor metabol circuit enhanc glucos independ tca tricarboxyl acid cycl intermedi nadnadh ratio subsequ increas fatti acid deriv l carnitin enhanc mitochondri oxpho atp product instead glycolysi depend also demonstr modul rb regul transcript factor ef result metabol perturb conclus demonstr rb hk critic regul cellular bioenerget profil identifi alter tumor metabol potenti therapeut target cancer lack function rb protein
|
D012175;D019572
|
T191
|
36,291,050
|
tumor infiltr dendrit cell decis role cancer immunosurveil immunoedit tumor cell toler tumor microenviron play key role progress tumorigenesi tumor progress metastasi accumul data reveal dendrit cell dcs appear play key role develop progress metastat neoplasia drive immun system dysfunct establish immunosuppress vital tumor evas host immun respons consequ review discuss function tumor infiltr dcs immun cell signal pathway lead treatment resist tumor recurr immunosuppress also review dc metabol differenti plastic essenti metastasi develop lung tumor furthermor take account interact myeloid cell dcs tumor relat immunosuppress specif look molecular immun relat mechan tumor microenviron result reduc drug sensit tumor relaps well method combat drug resist focus immunosuppress tumor network dcs play crucial role modul immun respons especi cancer progress dcs may switch play immunostimulatori inhibitori role articl main emphasi tumor infiltr dcs address affect tumor growth expans highlight innov approach therapeut modul immunosuppress dcs necessari futur person therapeut approach
|
D003713;D013601
|
T025
|
36,291,048
|
glucos incorpor graphit matrix electroanalysi trimethoprim antibiot drug trimethoprim tmp use treat bacteri infect human anim frequent tmp use along sulfonamid howev larg portion tmp excret activ state pose sever problem human environ sensit rapid cost effect analyt tool requir monitor tmp concentr biolog environment sampl henc studi propos analyt methodolog analyz tmp clinic biolog environment sampl investig carri use glucos modifi carbon past electrod g cpe employ voltammetr techniqu electrochem behavior examin mm tmp solut optimum ph phosphat buffer solut influenc scan rate electro oxid tmp studi within rang vs effect ph scan rate variat reveal proton transfer oxid moreov diffus phenomena govern irrevers electrod reaction probabl suitabl electrod interact reaction mechan propos electrochem oxid tmp tmp quantit estim differenti puls voltammetri dpv techniqu concentr rang tablet spike water urin analysi demonstr select method develop electrod rapid simpl sensit cost effect
|
D006108
|
T196;T109
|
36,291,047
|
effici entrap alpha synuclein biotinyl antibodi kcc nh cs applic sensit diagnosi parkinson use recognit biomark innov electrochem label free immunosensor biomed analysi neurodegen diseas earli detect parkinson diseas pd critic issu term effici alpha synuclein syn biomark pd check alpha synuclein syn major constitu lewi bodi pathogen hallmark synucleinopathi includ pds dementia lewi bodi multipl system atrophi studi kcc nh cs conjug biotinyl ab entrap p cd polym caviti use approach novel electrochem label free immunosensor design quantif syn real human sampl purpos glassi carbon electrod electropolymer p cd biopolym provid excel matrix entrap kcc nh cs load biotinyl antibodi syn use chronoamperometr techniqu propos immunosensor show suitabl rang ngml determin syn addit low limit quantif engin biosensor obtain ngml develop immunosensor adequ stabil sensit select togeth eas manufactur make promis diagnost techniqu research studi also pave way applic synerget effect cd kcc nh cs biomed analysi near futur
|
D010300;D019636;D015374
|
T047;T059;T075
|
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