PMID
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36.4M
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36,291,684
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systemat review mirna cfdna potenti biomark liquid biopsi myocard inflammatori dilat cardiomyopathi myocard inflammatori dilat cardiomyopathi cardiac diseas lead heart failur liquid biopsi concept replac tradit biopsi special blood test studi aim summar assess use microrna circul free dna biomark myocardi inflamm systemat review search scopus embas web scienc pubm studi measur microrna serumplasmacardiac tissu circul free dna myocard non ischem dilat cardiomyopathi human healthi subject anoth cardiac diseas serv compar includ data extract mirna screen assess use scale creat hous high grade mirna assess usabl liquid biopsi biomark record identifi elig mirna found identifi studi measur circul free dna total screen mirna includ final assess select best potenti candid abl assess risk bias final inclus decis made consensus serum level three mirna mir chr mir mir best candid myocardi inflamm liquid biopsi panel studi necessari prove role specif sensit
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D002311;D009205;D035683;D000073888
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T123;T047;T114
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36,291,683
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season chang biochem constitu green seawe chaetomorpha antennina covelong india seawe well known wealth nutrit benefit provid ecolog support associ fauna season influenc biochem characterist affect ecolog econom valu present studi evalu pigment primari secondari metabolit miner antioxid properti green seawe chaetomorpha antennina grow intertid rock along covelong coast india differ season june march signific variat found level antioxid miner metabolit differ season eg amino acid level highest post monsoon lowest summer monsoon found highest concentr fatti acid thalli lipid peroxid total antioxid activ maximum level post monsoon indic oxid damag respons signific variat found level photosynthet pigment outcom inde suggest season variat biochem nutrient profil c antennina suggest harvestingcollect c antennina differ nutrient metabolit perform respect season
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D012624;D000460
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T002;T204
|
36,291,682
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biomimet artifici proton channel one common biochem process proton transfer cell membran signific physiolog function live organ proton transloc mechan extens studi howev mechanist detail transport still need last decad field artifici proton channel continu growth understand phenomena confin water channel compon mediat proton dynam import thus proton transfer continu activ area experiment theoret investig acquir insight proton transfer mechan import enlighten provid direct applic sever field review present overview develop various artifici proton channel focus most design self assembl behavior proton transport activ perform bilay membran comparison protein proton channel end discuss potenti applic well futur develop perspect
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D011522;D032701
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T090;T196
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36,291,681
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il il progress marker syphili peopl live hiv systemat review much known natur histori syphili howev less known immun respons even less known peopl live hiv plwh due lack anim model studi host pathogen interact remain unclear host elimin bacteria attempt elucid immun respons infect summar report data systemat review found seven paper includ plwh accur describ immun respons treponema pallidum sinc lymphopenia report upon coinfect hand least sixteen paper describ host pathogen interact individu cell popul use inform establish kinet immun respons syphili hypothes cd cell th rex cell worsen progress diseas plwh hallmark cytokin il il two cytokin may play import role biomark
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D013587;D015658
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T047
|
36,291,680
|
receptor transport protein rtp hypothalamus involv develop antinocicept toler morphin receptor transport protein rtp one receptor chaperon protein contribut matur membran traffick opioid receptor heterom consist mu mopr delta dopr opioid receptor mopr dopr although mopr dopr known mediat develop morphin toler extent rtp play role process elucid given rtp upregul repeat administr morphin especi hypothalamus investig effect hypothalamus select ablat rtp develop antinocicept toler morphin studi generat rtpflox mice select knock rtp use local inject adeno associ virus express cre recombinas aav cre hypothalamus aav cre inject partial signific decreas level rtp express suppress develop antinocicept toler morphin next examin mechan regul rtp found neuron cell rtp induct via gi mapk activ microgli cell induct via toll like receptor togeth studi highlight role mor activ regul rtp turn play import role modul morphin effect vivo
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D009020;D051197
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T192;T121;T116;T109
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36,291,679
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discoveri mao b inhibitor machin learn topom comfa molecular dock multi spectroscopi approach alzheim diseas ad common type dementia serious disrupt normal life monoamin oxidas b mao b import target treatment ad studi machin learn approach appli investig identif model mao b inhibitor result show identif model mao b inhibitor k nearest neighbor knn algorithm predict accuraci fold cross valid test independ test set respect second quantit activ predict model mao b investig topom comfa model two separ cut mode approach use predict activ mao b inhibitor result show cut model q cross valid correl coeffici r non cross valid correl coeffici determin train test set respect addit molecular dock employ analyz interact mao b inhibitor final base propos predict model hydroxyphenyl trimethoxyphenyl propan one lb predict potenti mao b inhibitor valid multi spectroscop approach includ fluoresc spectra ultraviolet spectrophotometri
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D008996;D000544
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T121;T047;T048;T109
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36,291,678
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metabolom profil indonesian betel quid consumpt areca nut alon form betel quid bq negat health effect carcinogen human indonesia one largest produc areca nut worldwid yet littl known biomolecular composit indonesian areca nut bqs recent shown phenol alkaloid content indonesian bqs exhibit distinct geograph differ profil first time metabolom bq constitu four region indonesia use non target gas chromatographi mass spectrometri gc ms analysi addit well known alkaloid analysi small molecul profil tentat identifi phytochem bq includ main benzenoid terpen well acid aldehyd alcohol ester safrol potenti genotox benzenoid found abund betel piper betl infloresc west papua detect areca nut sampl indonesian region except west papua terpen most detect betel leav inflorescencestem areca nut husk betel leaf infloresc stem bq mixtur express distinct metabolit pattern signific variat content concentr metabolit found across differ geograph region summari first metabolom studi bqs use gc ms result demonstr molecular constitu bqs vari geograph suggest differenti diseas induc capac bqs may reflect distinct chemic composit
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D001114;D000470
|
T121;T123;T109;T131;T002
|
36,291,677
|
serratiopeptidas integr view multifacet therapeut enzym microbi product use treatment differ diseas mani centuri serratiopeptidas enzym provid new hope covid infect patient nowaday anti inflammatori drug easi obtain minim expenditur microbi sourc serratia sp identifi one effici bacteria produc serratiopeptidas screen new effici bacteri strain differ sourc interest recent year serratiopeptidas remain well known anti inflammatori drug choic serratiopeptidas cheaper safer anti inflammatori drug altern nsaid multifacet properti serratiopeptidas may lead toward arthriti diabet cancer thrombolyt treatment exist serratiopeptidas treatment combin antibiot popular treatment postop swell although exclus number serratiopeptidas produc strain deriv urg new recombin strain enhanc product enzym review explor properti serratiopeptidas differ therapeut aspect industri product various analyt techniqu use enzym recoveri addit review highlight therapeut clinic aspect serratiopeptidas enzym combat covid induc respiratori syndrom
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D000086382
|
T047;T067
|
36,291,676
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biochem structur character chi class glutathion transferas snapshot glutathion transferas encod sll gene cyanobacterium synechocysti sp strain pcc glutathion transferas gsts constitut widespread superfamili enzym notabl involv detoxif process andor special metabol cyanobacterium synechocsyti sp pcc syngstc chi class gst gstc thought particip detoxif process methylglyox toxic product cellular metabol compar genom analysi show gstcs present order cyanobacteria except basal order gloeobacteral enzym also detect marin freshwat noncyanobacteri bacteria probabl result horizont gene transfer event gstcs shorter residu compar cytosol gsts well conserv sras motif activ site sras syngstc crystal structur syngstc complex glutathion adopt canon gst fold open activ site helic except short transfer multipolar electron densiti analysi allow fine descript solv structur unexpect ser electrostat influenc glutathion usual observ serinyl gsts sa variant slight less effici wild type molecular dynam simul suggest stabil protein backbon rather anchor site glutathion
|
D005982;D046939
|
T007;T126;T116
|
36,291,675
|
dig structur predict alphafold low confid disord beyond alphafold af creat breakthrough biolog provid three dimension structur model whole proteom sequenc unpreced level accuraci addit af plddt score relat model confid shown provid good measur residu wise disord combin af predict pyhca tool previous develop identifi foldabl segment estim orderdisord ratio singl protein sequenc focus analysi af predict avail refer proteom afdb v particular long foldabl segment amp gt amino acid exhibit characterist solubl domain estim pyhca among segment provid global analysi low plddt valu along entir length compar characterist segment high plddt valu highlight case contain condit order well case could form well fold structur escap af predict due shallow multipl sequenc align andor undocu structur fold af pyhca therefor advantag combin unravel cryptic structur featur whole proteom refin predict differ flavor disord
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D020543;D005668
|
T123;T116;T131;T109
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36,291,674
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next generat sequenc genotyp variant genet associ heat shock protein hspab singl nucleotid polymorph g locus heat toler pilot quasi experiment studi heat toler exert heat stroke eh rare health condit describ characteris never genet solv knowledg role singl nucleotid polymorph snps heat shock protein hsps gene associ heat toler eh limit pilot studi aim identifi snp hspab hspaa dnaja gene associ heat toler eh histori quasi experiment design particip compris australian defenc forc member adf histori eh general popul genom dna sampl extract venous blood sampl particip sequenc analys snp forti four per cent particip heat intoler histori eh among particip histori eh associ heat toler hspab snp g locus howev associ hspab hspaa snp heat toler particip distribut dnaja snp conclus find indic associ hspab genet variant g locus heat toler among adf particip histori eh research larger number militari particip shed light associ hsp gene heat toler
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D020641;D000071436
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T039;T086
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36,291,673
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bibliometr analysi research role bdnf depress treatment brain deriv neurotroph factor bdnf wide distribut wide studi neurotroph factor mammalian brain play key role depress mechan action antidepress current larg number studi role bdnf pathogenesi therapeut mechan depress quantiti qualiti studi howev unknown give beginn quicker introduct research topic therefor perform bibliometr analysi total public includ obtain public topic web scienc databas varieti bibliograph element collect includ annual public author countriesregion institut journal keyword moreov found oxid stress neuroinflamm hotspot field recent year collect studi provid comprehens summari analysi role bdnf depress treatment offer meaning valu beginn topic
|
D019208;D003863
|
T123;T184;T116;T048
|
36,291,672
|
lung organoid smoke research current advanc futur promis tobacco smoke establish contribut pathogenesi various respiratori diseas includ chronic obstruct pulmonari diseas copd lung cancer asthma howev major hurdl mechanist studi role smoke human lung remain part due lack ex vivo experiment model ambigu data anim model best recapitul architectur pathophysiolog human lung recent develop lung organoid cultur system open new avenu respiratori diseas research organoid prove sophist ex vivo model function structur mimic human lung better tradit use model review discuss recent advanc lung organoid system may help us better determin injuri immunolog effect smoke human lung provid suggest futur research direct
|
D009940;D029424
|
T047;T024
|
36,291,671
|
sex differ neuropsychiatr effect pharmacokinet cannabidiol scope review cannabidiol cbd non intox cannabinoid compound divers molecular target potenti therapeut effect includ effect relev treatment psychiatr disord scope review sought determin extent sex gender consid potenti moder neuropsychiatr effect pharmacokinet cbd case articl screen retriev search pubmedmedlin scopus googl scholar psycinfo cinahl though met elig criteria eight studi preclin model four studi human among preclin studi three suggest sex may influenc long term effect gestat adolesc exposur cbd two found impact sex cbd modul addict relev effect tetrahydrocannabinol thc two found antidepress like effect cbd male one found greater plasma liver cbd concentr femal compar male among human studi two found sex differ cbd pharmacokinet patient sampl one found greater plasma cbd concentr healthi femal compar male one found evid sex differ effect cbd respons trauma recal patient post traumat stress disord ptsd studi identifi consid role gender cbd treatment effect discuss potenti implic current limit exist literatur
|
D002185;D002186;D013313
|
T121;T048;T109
|
36,291,670
|
anti laminin type mucous membran pemphigoid anti laminin lm type mucous membran pemphigoid mmp rare autoimmun bullous diseas origin discov anti epiligrin cicatrici pemphigoid anti lm type mmp clinic manifest similar type mmp distinguish detect circul autoantibodi lm group other establish number immunolog method vari sensit specif detect anti lm autoantibodi howev none establish method wide use clinic diagnosi current unifi standard treatment difficult complet cure anti lm type mmp addit increas bodi evid suggest may strong correl anti lm type mmp tumor articl review current progress diagnosi treatment anti lm type mmp well possibl correl anti lm type mmp tumor
|
D001327;D009369;D010390;D010391
|
T047;T191
|
36,291,669
|
overview molecular mechan fabri diseas fabri diseas fd omim rare genet lysosom storag disord lsd lsds character inappropri lipid accumul lysosom due specif enzym defici fd defect enzym galactosidas gal due mutat gla gene x chromosom enzym defici lead continu deposit neutral glycosphingolipid globotriaosylceramid lysosom numer tissu organ includ endotheli cell smooth muscl cell corneal epitheli cell renal glomeruli tubul cardiac muscl ganglion cell nervous system condit lead progress organ failur prematur death increas understand fd lsd general led recent year introduct enzym replac therapi ert aim slow halt progress metabol disord review provid overview main featur fd focus molecular mechan role biomark
|
D000795
|
T047
|
36,291,668
|
clinic signific immun infiltr analys cuproptosi relat human copper proteom gastric cancer human copper cu proteom also term cu bind protein cbp respons transport free cu cell relat cuproptosi howev role gastric cancer gc report
|
D013274
|
T191
|
36,291,667
|
fdcsp immun associ prognost biomark hpv posit head neck squamous carcinoma background head neck squamous carcinoma hnsc pose major threat human life role human papillomavirus hpv infect initi progress hnsc becom wide accept hpv posit hpv hnsc shown uniqu respons cancer therapi may due differ immun cell infiltr critic determin immun respons hpv hnsc regul method transcriptom data hnsc cancer genom atlas tcga gene express omnibus geo databas analyz cibersort algorithm use calcul immun cell infiltr hnsc fdcsp express level detect qpcr hnsc tissu collect nanfang hospit result follicular dendrit cell secret protein fdcsp high express hpv hnsc higher express fdscp associ favor prognosi hpv hnsc sampl fdcsp signific increas proport follicular helper cell tfhs fdcsp express also found associ tp mutat status hpv hnsc function fdcsp intim connect chemokin pathway particular c x c motif chemokin ligand cxcl verifi high express fdcsp hpv hnsc higher fdcsp close relat prognosi hnsc sampl collect qpcr conclus collect find may provid fresh evid fdcsp potenti chemokin associ prognost biomark hpv hnsc
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D006258;D030361
|
T047;T191
|
36,291,666
|
traumat brain injuri lead alter contusion cortic mirna involv dementia compel evid head injuri signific environment risk factor alzheim diseas ad histori traumat brain injuri tbi acceler onset ad amyloid plaqu tau aggreg observ post mortem brain tbi patient howev mechan lead ad neuropatholog tbi still unknown studi hypothes focal tbi induc chang mirna express around affect area result alter express gene involv neurodegener ad patholog purpos perform mirna array extract rat subject experiment tbi use control cortic impact cci model around contus observ alter mirna associ dementiaad compar contralater side specif express mir signific upregul mir b mir mir b mir mir downregul via qpcr confirm result addit group injur rat compar nave anim interest chang mirna concomit alter gene express mrnas involv amyloid generat tau patholog app cleav enzym bace glycogen synthas gsk addit increas level neuroinflammatori marker tnf glial activ neuron loss tau phosphoryl observ pericontusion area therefor result suggest secondari injuri cascad tbi affect mirna regul express gene involv ad dementia
|
D000070642;D000544;D035683;D003288
|
T123;T114;T037;T047;T048
|
36,291,665
|
immunosenesc inflammag lung senesc asthma elder preval asthma older adult grow along increas global life expect due poor clinic consequ high mortal advanc understand pathophysiolog asthma older patient sought provid prompt treatment age relat alter function immun system lung parenchyma occur throughout life alter advanc age promot various stimuli includ pathobiont fungi virus pollut damag associ molecular pattern deriv impair cell abandon cell debri senesc cell age relat chang innat adapt immun respons term immunosenesc includ impair phagocytosi antigen present enhanc proinflammatori mediat generat product senesc associ secretori phenotyp immnunosenesc could promot inflammag chronic low grade inflamm contribut late onset adult asthma asthma elder along age relat pulmonari diseas chronic obstruct pulmonari diseas pulmonari fibrosi due lung parenchyma senesc age patient asthma exhibit local system type non type inflamm associ clinic manifest discuss immunosenesc contribut immun respons combin type inflamm inflammag asthma elder present overview age relat featur immun system lung structur
|
D000068884;D001249;D004785
|
T131;T039;T047
|
36,291,664
|
target neuroinflamm osteoarthr intra articular adelmidrol neuroinflamm emerg therapeut target chronic degen autoimmun diseas osteoarthr oa rheumatoid arthriti mast cell mcs play key role homeostasi joint activ mcs induc releas huge number mediat fuel fire neuroinflamm particular synovi mcs releas substanc acceler degrad extra cellular matrix caus morpholog joint chang cartilag damag induc prolifer synovi fibroblast angiogenesi sprout sensori nerv fiber mediat chronic pain palmitoylethanolamid pea well known mcs modul osteoarthrit joint level signific reduc adelmidrol synthet deriv azela acid belong aliamid famili pea enhanc preclin clinic investig show intra articular administr adelmidrol signific reduc mc infiltr pro inflammatori cytokin releas cartilag degener combin high molecular weight hyaluron acid adelmidrol effect use knee osteoarthr signific improv analgesia function record
|
D006820;D020370
|
T123;T121;T109;T122;T047
|
36,291,663
|
simul calcium dynam realist three dimension domain cytosol concentr free calcium ion ca import intracellular messeng cell type spatial distribut ca often critic salivari gland acinar cell polaris epitheli cell whose princip function transport water thus secret saliva ca control secret primari saliva increas ca localis apic region cell henc quantit explan ca control saliva secret must take care account spatial distribut various ca sourc ca sink ca sensit ion channel base optic slice previous construct anatom accur three dimension model seven salivari gland acinar cell thus shown model ca respons confin apic region cell suffici provid quantit predict explan primari saliva secret howev reconstruct anatom accur cell extrem time consum ineffici present altern most autom method construct three dimension cell approxim anatom accur show new construct preserv quantit accuraci model
|
D002118;D061354
|
T123;T196;T121;T025
|
36,291,662
|
share genet regulatori network contribut neuropath inflammatori pain multi omic system analysi mechan chronic pain complex genet factor play essenti role develop chronic pain neuropath pain np inflammatori pain ip two primari compon chronic pain previous studi uncov common biolog process np ip howev share genet mechan remain poor studi util multi omic systemat analys investig share genet mechan np ip first integr sever genom wide associ studi gwass multi omic data reveal signific overlap gene co express modul np ip uncov share biolog pathway includ previous report mitochondri electron transport atp metabol stress role genet factor chronic pain neurodegen diseas second identifi conserv key driver kds contribut np ip contain two well establish pain gene ilb oprm novel potenti pain gene car serpin subnetwork kds highlight process involv immun system final gene express analysi kds mous model underlin two kds slca kcnq unidirect regulatori function np ip studi provid strong evid support current understand share genet regulatori network under np ip potenti benefit futur common therapeut avenu chronic pain
|
D059350;D009437
|
T184;T047
|
36,291,661
|
role clusterin transport pathogenesi alzheim diseas blood brain barrier interfac systemat review alzheim diseas ad consid chronic debilit neurolog ill increas impact older age popul protein includ clusterin clu apolipoprotein j transport link ad caus oxid stress therefor activ affect various function involv complement system inactiv lipid transport chaperon activ neuron transmiss cellular surviv pathway transport known bind amyloid beta peptid major pathogen factor ad hand transport also activ blood brain barrier bbb barrier prevent harm substanc enter exit brain therefor review discuss emphas role clu transport clu link molecular mechan bbb interfac pathogenesi ad
|
D051152;D000544
|
T129;T047;T116;T048
|
36,291,660
|
galectin natur bind ligand mcam cd muc melanoma cell interact promot melanoma progress melanoma cell adhes molecul mcam cd muc heavili glycosyl transmembran protein marker melanoma metastasi express advanc primari melanoma metastasi rare benign naevi normal melanocyt evid shown activ mcam cell surfac play vital role melanoma progress metastasi howev natur mcam bind ligand initi mcam activ melanoma far remain elus studi reveal galectin galactosid bind protein common overexpress mani cancer includ melanoma natur associ mcam surfac skin uveal melanoma cell bind galectin mcam via link glycan mcam induc mcam dimer cluster cell surfac subsequ activ downstream akt signal lead increas number import step melanoma progress cell prolifer adhes migrat invas thus galectin natur bind ligand mcam melanoma interact activ mcam promot mcam mediat melanoma progress target galectin mcam interact may potenti use therapeut strategi melanoma treatment
|
D037502;D008545
|
T129;T191;T116
|
36,291,659
|
stat inhibitor novel insight anticanc therapi pancreat cancer signal transduc activ transcript stat famili intracellular cytoplasm transcript factor involv mani biolog function mammalian signal transduct among stat involv cell prolifer differenti apoptosi inflammatori respons despit advanc treatment pancreat cancer past decad prognosi patient pancreat cancer remain poor stat shown play pro cancer role varieti cancer inhibitor stat use pre clinic clinic studi review relationship stat pancreat cancer latest result use stat inhibitor pancreat cancer aim provid insight idea around stat inhibitor new generat chemotherapeut modal pancreat cancer
|
D050796;D010190
|
T123;T191;T116
|
36,291,658
|
gene geographi cell communiti biomolecul behavior import social determin health much scientif work past decad link health outcom diseas risk genom deriv better understand diseas mechan genet molecular level howev genom alon quit captur full pictur one overal health modern comput biomed research move direct includ socialenvironment factor ultim affect qualiti life health outcom popul individu level futur studi diseas lie hand social determin health sdoh answer press clinic question address healthcar dispar across popul group integr electron health record ehr perspect articl argu sdoh futur diseas risk health outcom studi due vast coverag patient overal health sdoh data avail ehr improv tremend year ehr toolkit diagnosi code wearabl devic census tract inform studi diseas risk discuss avail sdoh data challeng sdoh implement futur real world evid studi next step report studi outcom equit action way
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D064890;D011788
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T033;T078;T067
|
36,291,657
|
covid gwab web base predict covid host gene via network boost genom wide associ data host genet affect suscept respons viral infect search host gene contribut covid host genet initi hgi form investig genet factor involv covid via genom wide associ studi gwas gwas suffer limit statist power general gene pass convent signific threshold statist limit may overcom boost weak associ signal integr independ function inform molecular interact addit boost result evalu various independ data connect covid present covid gwab web base tool boost origin gwas signal covid patient take signal interactom neighbor covid gwab take summari statist covid hgi user input data repriorit candid host gene covid use humannet co function human gene network current version covid gwab provid pre process data releas hgi addit covid gwab provid web interfac summari augment gwas signal predict evalu appear frequenc covid literatur singl cell transcriptom data associ pathway web server also enabl brows candid gene network
|
D055106;D000086382
|
T063;T047;T067
|
36,291,656
|
exosom mira promot cytarabin resist myelodysplast syndrom activ wnt catenin signal pathway cytarabin ara c one frontlin therapi clonal hematopoiet stem cell disord myelodysplast syndrom mds acut myeloid leukemia aml ara c resist often occur lead treatment failur exosom microrna mirna mir small noncod rna play import role post transcript gene regul deliv recipi cell exosom regul target gene express mira report dysregul mani cancer includ mds aml howev effect exosom mira hematolog malign fulli investig studi qualit analysi show signific enhanc express exosom mira mdsaml plasma subsequ function assay indic exosom mira transport downregul pten recipi cell furthermor activ wnt catenin signal pathway interfer ara c resist receipt mdsaml cell vitro vivo altogeth find offer novel insight plasma exosom mira particip ara c resist mdsaml propos mira potenti therapeut target mdsaml
|
D009190;D015470;D035683
|
T123;T046;T191;T114
|
36,291,655
|
andrographolid inhibit corneal fibroblast myofibroblast differenti vitro corneal opacif due fibrosi lead caus blind worldwid fibrosi occur mani caus includ trauma photorefract surgeri microbi kerat infect cornea chemic burn yet pauciti therapeut prevent treat corneal fibrosi studi aim determin andrographolid labdan diterpenoid found andrographi panicul anti fibrot properti furthermor evalu andrographolid could prevent differenti fibroblast myofibroblast vitro given transform growth factor beta tgf stimul persist myofibroblast cornea primari compon fibrosi demonstr andrographolid inhibit upregul alpha smooth muscl actin sma mrna protein rabbit corneal fibroblast rcfs thus demonstr reduct transdifferenti myofibroblast immunofluoresc stain tgf stimul rcfs confirm dose depend decreas sma express treat andrographolid addit andrographolid well toler vivo impact corneal epitheli rat debrid model data support futur studi investig use andrographolid anti fibrot corneal wound heal
|
D053773;D004224
|
T123;T121;T116;T109
|
36,291,654
|
aggrav gut microbiota metabolom imbal associ hypertens patient comorbid atrial fibril disord gut microbiota gm co contributor atrial fibril af hypertens htn might associ af risk htn studi aim explor alter gm communiti metabol pattern htn patient af htn af non af htn patient fecal metagenom serum metabolom analysi compar non af htn patient signific microbi alter p includ increas microbi divers p amp lt shift enterotyp domin prevotella bacteroid abund diseas link genera ruminococcus streptococcus veillonella dorea enterococcus observ htn af patient speci base random forest predict model associ risk af occurr htn patient furthermor gm metabol profil dramat differ htn htn af patient especi imbal satur unsatur fatti acid htn af patient circul palmit acid arachidon acid level signific elev level tetracosahexaeno acid oleic acid linol acid stearic acid decreas p amp lt vip amp gt mediat gut microbi indirect effect af p amp lt thus find preliminarili indic exacerb dysbiosi gm relev metabolit associ high af suscept might potenti target af predict prevent htn
|
D001281;D000069196;D006973
|
T047;T046;T001;T007
|
36,291,653
|
explor comput data amplif imput discoveri type diabet td biomark limit human dataset type diabet td devast diseas serious health complic earli td biomark could enabl time detect prevent onset clinic symptom paramount current unavail despit promis omic approach far fail deliv biomark like due fragment natur inform obtain singl omic approach recent demonstr util parallel multi omic identif td biomark signatur studi also identifi challeng
|
D003922
|
T047
|
36,291,652
|
synbiot antioxid properti mechan benefit human anim health narrat review antioxid often associ varieti anti age compound ensur human anim health longev food diet supplement anim plant common exogen sourc antioxid howev microbi base product includ probiot deriv recogn antioxid properti numer studi clinic trial number public probiot antioxid capac action mechan expand synbiot combin probiot prebiot still emerg antioxid metabolit properti synbiot mode action differ effect human anim health review discuss synbiot generat almost unlimit possibl antioxid compound may superior perform compar compon addit complementari effect especi synergist action either combin antioxid prebiot probiot convert substrat generat antioxid compound superior activ synbiot base new rout suppli natur antioxid appear relev promis human anim health prevent treatment better understand various compon interact within synbiot key generat higher qualiti quantiti bioavail antioxid biotic sourc
|
D058616;D019936
|
T168;T007
|
36,291,651
|
introduct tradit medicin role prevent treatment emerg emerg diseas infecti diseas threat human health global relentless effort research enabl us overcom diseas use antivir antibiot agent discov employ unfortun microorgan capabl adapt mutat time antibiot antivir resist ensu mani challeng treat infect failur microorgan respond therapeut agent led chronic infect complic prevent loss life thus multidisciplinari approach collabor warrant creat potent effect versatil therapi prevent erad old newli emerg diseas recent past natur medicin proven effect various ill pharmaceut agent current use trace origin natur product one way shape form full potenti natur product yet realiz numer natur resourc explor analyz merit continu support research analysi ancient treatment system explor full potenti employ altern princip therapi
|
D000998;D001688
|
T121;T123
|
36,291,650
|
reorgan cell compartment induc stress discoveri intrins disord protein idp order structur nevertheless perform essenti function open new era understand cellular compartment threw bridg most mechanist model organ live matter idea high dynam function soft matter paradigm base notion major role liquid liquid phase separ llps biopolym spatial tempor organ intracellular space llps lead format self assembl membran less organell mlos mlos multicompon multifunct biolog condens high dynam structur composit allow fine tune regul various intracellular process idp play central role assembl function mlos llps import regul chemic reaction insid cell clear illustr reorgan intracellular space stress respons reaction various type stress stress induc mlos appear cell enabl preserv genet protein materi unfavour condit addit stress caus structur function composit chang mlos perman present insid cell review describ assembl stress induc mlos stress induc modif exist mlos eukaryot yeast prokaryot respons various stress factor
|
D064267
|
T123;T116
|
36,291,649
|
neutrophil extracellular trap net ocular diseas updat neutrophil extracellular trap net net like complex expel neutrophil compos cell free deoxyribonucl acid dna histon neutrophil granul protein besid captur elimin pathogen net also exacerb inflammatori respons associ various diseas includ system lupus erythematosus rheumatoid arthriti psoriasi current grow report net involv pathogenesi ocular diseas review primarili focus pathogenesi net ophthalmolog field highlight import serv potenti target therapi ocular diseas
|
D065206;D000073888
|
T026;T123;T114
|
36,291,648
|
integr quantit target lipidom proteom reveal uniqu fingerprint multipl metabol condit aberr lipid lipoprotein metabol pathway lead numer diseas includ cardiovascular diseas diabet neurolog disord cancer integr quantit lipid lipoprotein profil human plasma may provid power approach inform earli diseas diagnosi prevent studi leverag data driven quantit target lipidom proteom identifi specif molecular chang associ differ metabol risk categori includ hyperlipidem hypercholesterolem hypertriglyceridem hyperglycem normolipidem condit base quantit character serum sampl individu determin individu lipid speci protein signific regul relat normolipidem group establish protein lipid topolog network metabol categori link dysregul protein lipid defin metabol pathway evalu differenti power integr lipidom proteom data built artifici neural network model simultan accur categor sampl metabol risk categori base determin lipidom proteom profil togeth find provid new insight molecular chang associ metabol risk condit suggest new condit specif associ apolipoprotein lipid may inform new biomark discoveri lipid metabol associ disord
|
D000081362;D052439
|
T047;T091;T109
|
36,291,647
|
activ nrf optimis immun respons intracerebr haemorrhag haemorrhag brain parenchyma devast manifest spontan intracerebr haemorrhag ich head trauma context vascular dementia randomis control trial reliabl shown haemostat treatment aim limit ich haematoma expans surgic approach reduc haematoma volum effect consequ treatment modul pathophysiolog respons ich may caus secondari brain injuri appeal follow ich microglia monocyt deriv cell recruit peri haematom environ phagocytos haematoma breakdown product secret inflammatori cytokin may trigger protect harm respons transcript factor nrf activ oxid stress high express central nervous system microglia macroglia activ nrf induc transcript programm characteris increas express antioxid haem heavi metal detoxif proteostasi gene well suppress proinflammatori factor therefor nrf activ may facilit adapt protect immun cell respons ich boost resist oxid stress heavi metal toxic whilst limit harm inflammatori signal contribut blood brain barrier dysfunct cerebr oedema review consid respons immun cell ich might modul nrf activ final propos potenti therapeut strategi har nrf improv outcom patient ich
|
D051267;D006490
|
T123;T121;T116
|
36,291,646
|
target cholesterol homeostasi improv recoveri experiment optic neuriti acut optic neuriti common caus vision loss often associ multipl sclerosi ms cholesterol recycl identifi key limit factor recoveri demyelin event thus purpos studi determin augment cholesterol transport gentis acid ga benefit retin ganglion cell rgc develop myelin organoid system enabl recoveri ocular phenotyp upon system ga treatment mog induc experiment autoimmun encephalomyel eae model retin organoid treat ga demonstr acceler matur compar convent deriv organoid evidenc improv organ brna gfprgc increas synaptogenesi ga supplement brain organoid lead fold increas ng olig express week ga inject eae mice signific lessen motor sensori impair protect amplitud pattern electroretinogram record preserv visual acuiti studi period day furthermor ga treat eae mice reveal diminish gclipl complex thin compar untreat eae mice optic nerv histopatholog reveal less sever grade demyelin ga treat eae cohort fewer infiltr cell observ intervent improv cholesterol homeostasi may viabl approach promot rehabilit ms patient
|
D009902;D004681;D009103
|
T047;T050
|
36,291,645
|
look pathogenesi rabi lyssavirus strain pasteur vaccin prism disord base bioinformat rabi neurolog diseas caus death everi year rabi patient becom symptomat effect treatment ill unvaccin individu case fatal rate rabi close french scientist loui pasteur mile roux develop first vaccin rabi administ virus reach brain modern rabi vaccin impart long last immun virus save peopl everi year howev rabi virus suppress host immun respons enter cell brain make death like studi aim make use disord base proteom bioinformat determin potenti impact intrins disord protein region idpr proteom rabi virus might infect lethal diseas studi use proteom rabi lyssavirus rabv strain pasteur vaccin pv one best understood strain due use first rabi vaccin model data report studi line hypothesi high level intrins disord phosphoprotein p protein nucleoprotein n protein allow particip creation negri bodi might help virus suppress antivir immun respons host cell addit studi suggest could link disord matrix protein modul viral transcript disord region protein might possibl role initi viral bud within cell furthermor check preval function disord set host protein direct involv interact rabv protein hope new insight aid develop treatment rabi effect infect
|
D011820;D011818;D011819;D064267
|
T129;T121;T123;T116;T109;T005;T047
|
36,291,644
|
aberr gangliosid function underpin dysregul myelin insulin signal cytokin express link room therapi gangliosid molecul wide present plasma membran mammalian cell particip varieti process includ protein organ transmembran signal cell adhes gangliosid abund grey matter brain critic involv postnat neural develop function common precursor major brain gangliosid gm form sialyl lactosylceramid four deriv b seri gm gda gdb gtb constitut brain gangliosid impair gangliosid metabol due genet abnorm gm synthas associ sever neurolog disord apart latest genom wide associ translat studi suggest role gene involv brain gangliosid synthesi less pervas psychiatr disord remark recent anim studi show abnorm gangliosid function result dysregul neuroinflamm aberr myelin alter insulin receptor signal time molecular featur well establish accompani development psychiatr disord attent deficit hyperact disord adhd autism spectrum disord asd led us hypothes role defici gangliosid function development neuropsychiatr disord warrant gene associ clinic studi address question critic review literatur discuss hypothesi focus recent studi stgal defici mice addit elabor therapeut potenti various anti inflammatori remedi treatment development neuropsychiatr condit relat aberr gangliosid function
|
D005732;D005677
|
T121;T123;T109
|
36,291,643
|
elucid structur impact protein indel effect amino acid insert delet indel remain rather explor area structur biolog variat oftentim caus numer diseas phenotyp spite research studi indel structur signific remain limit primarili due lack experiment inform comput method work fill gap model indel comput investig rigid differ wildtyp mutant variant one indel compar structur effect due indel differ effect amino acid substitut anoth type amino acid mutat finish perform correl analysi rigid base metric wet lab data abil infer effect indel protein fit
|
D011506;D054643
|
T045;T123;T116
|
36,291,642
|
structur achiev nh interact gln phe crystal structur collagen like peptid nh interact polar aromat residu well distribut protein whose stabil effect investig globular fibrous protein order gain structur insight side chain nh interact solv crystal structur collagen like peptid contain gln phe pair gln phe nh interact character quantum calcul molecular simul structur bioinformat analys indic nh interact robust various solvent condit distribut either protein surfac hydrophob core form wide rang distanc residu studi suggest nh interact play versatil role protein design includ engin hydrophob core solvent access surfac protein protein interfac
|
D010455;D003094
|
T121;T122;T123;T116
|
36,291,641
|
structur function relationship ribonucleolyt activ aifa sulfolobus solfataricus translat factor ifa high conserv protein play well recogn well character role protein synthesi nevertheless featur well abund cell suggest may perform addit function relat rna metabol undertaken structur function character aifa crenarcha sulfolobus solfataricus model organ confirm associ aifa sever rna molecul vivo demonstr protein endow ribonucleas activ specif long structur rna mean biochem structur approach show aifa exist monomer dimer conform monom format favor associ rna final model three dimension structur solfataricus aifa show extend posit charg surfac may explain strong tendenc associ rna vivo
|
D048229
|
T194
|
36,291,640
|
nusinersen induc diseas sever specif neurometabol effect spinal muscular atrophi intrathec deliveri nusinersen antisens oligonucleotid promot surviv motor neuron smn protein induct approv therapi spinal muscular atrophi sma employ nuclear magnet reson nmr spectroscopi longitudin character unknown metabol effect nusinersen cerebrospin fluid csf sma patient across diseas sever modul amino acid metabol common denomin biochem chang induc nusinersen distinct downstream metabol effect accord diseas sever sever sma patient nusinersen stimul energi relat glucos metabol intermedi sma patient nusinersen effect also relat energi homeostasi involv keton bodi fatti acid biosynthesi milder sma patient nusinersen main modul amino acid metabol moreov nusinersen modifi csf metabolom sever clinic group toward profil untreat sma patient milder diseas find reveal diseas sever specif neurometabol signatur nusinersen treatment suggest select modul peripher organ metabol cns direct therapi sever sma patient
|
D009134
|
T047
|
36,291,639
|
isol vitro silico anti alzheim anti inflammatori studi phytosteroid aerial part fragaria ananassa duch base pharmacolog import differ speci fragaria research carri isol bioactiv compound fragaria ananassa use convent graviti column chromatographi follow small analyt column purif two major compon isol plant materi structur compound accur confirm gc ms analysi comparison fragment pattern within librari instrument nmr analysi also use supplement structur evid compound observ cholestadien one compound identifi stigmast en one compound evalu anticholinesteras coxlox inhibit antioxid assay compound exhibit ic valu gml acetylcholinesteras butyrylcholinesteras cox cox lox respect similar ic valu compound target gml similar compound less potent abt dpph target ic valu rang gml despit low potenc compound antioxid target consid supplementari target alzheim inflamm molecular dock studi vitro anti alzheim anti inflammatori target also perform show excel bind interact respect target protein conclus isol phytosteroid fragaria ananassa evalu scientif anti alzheim anti inflammatori activ use vitro molecular dock approach
|
D031985;D010840
|
T121;T123;T109;T168;T002
|
36,291,638
|
impact renin angiotensin system pathogeni pharmacotherapeut neurodegen diseas brain neurodegen diseas bnd debilit condit especi characterist certain period life consid major threat human health current treatment limit mean challeng develop new option effici tackl differ compon pathophysiolog process condit renin angiotensin aldosteron system ras endocrin axi import peripher physiolog function blood pressur cardiovascular homeostasi well water sodium balanc system vascular resist function well document howev recent work highlight paracrin autocrin function ras differ tissu includ central nervous system cns known ras hyperactiv pro inflammatori pro oxid effect thus suggest pharmacolog modul could use manag condit present paper underlin involv ras compon pathophysiolog bnds parkinson diseas pd alzheim diseas ad multipl sclerosi ms huntington diseas hd motor neuron diseas mnd prion diseas prd well identif drug pharmacolog activ substanc act upon ras could allevi symptomatolog evolut thus contribut novel therapeut approach
|
D012084;D019636
|
T022;T047
|
36,291,637
|
lysin crotonyl emerg player dna damag respons dna damag respons ddr system play import role maintain genom stabil prevent relat diseas ddr network compris mani protein posttransl modif ptms protein work coordin manner counteract various genotox stress lysin crotonyl kcr newli identifi ptm occur core histon non histon protein various organ novel ptm classifi revers acyl modif regul varieti acylas deacylas intracellular crotonyl coa substrat concentr recent studi suggest kcr link cellular metabol gene regul involv numer cellular process review summar regulatori mechan kcr function ddr includ involv doubl strand break dsb induc transcript repress dsb repair dna replic stress respons
|
D008239;D006657
|
T123;T121;T116
|
36,291,636
|
local long term inner ear drug deliveri normal hear guinea pig anim model develop prevent treatment nois induc hear loss nois induc hear loss nihl one lead caus sensorineur hear loss global import current treatment choic patient hear problem hear aid cochlear implant howev current treatment restor physiolog hear develop prevent drug current focus hear research order test efficaci drug activ ingredi appli reliabl concentr period time osmot minipump provid local drug deliveri perilymph combin cochlear implant tube implant pump may lead increas hear threshold surgeri relat threshold shift complic examin factor nois aim present studi develop anim model examin substanc potenti prevent nihl purpos six male guinea pig unilater implant silicon cathet hook shape microcannula tip attach artifici perilymph contain osmot minipump one week surgeri anim expos four hour music piec present db spl induc threshold shift implant hook deliveri devic caus moder threshold shift allow detect addit nois induc temporari threshold shift method enabl investig drug effect deliv prior nois insult order establish prevent strategi nois induc temporari threshold shift establish drug deliveri approach allow releas drug inner ear known concentr known durat provid scientif tool basic research drug effect normal hear anim
|
D006317;D007758
|
T023;T037
|
36,291,635
|
protein data bank comprehens review structur hold worldwid util research educ student research collaboratori structur bioinformat protein data bank rcsb pdb fund unit state nation scienc foundat nation institut health depart energi support structur biologist protein data bank pdb data user around world rcsb pdb found member worldwid protein data bank wwpdb partnership serv us data center global pdb archiv hous experiment determin three dimension structur data biolog macromolecul wwpdb design archiv keeper rcsb pdb also respons secur pdb data week updat archiv rcsb pdb serv ten thousand data depositor use macromolecular crystallographi nuclear magnet reson spectroscopi electron microscopi micro electron diffract annual work perman inhabit contin rcsb pdb make pdb data avail research focus web portal charg without usag restrict mani million pdb data consum around globe also provid educ student general public introduct pdb relat train materi outreach educ focus web portal review articl describ growth pdb examin evolut experiment method structur determin view len pdb archiv provid detail account pdb archiv hold util research educ student worldwid
|
D019295;D011506
|
T123;T116;T091
|
36,291,634
|
deciph alphabet disord glu asp act differ local global properti compar fold protein sequenc intrins disord protein idp enrich polar charg amino acid glutam one enrich amino acid idp chemic similar amino acid aspart less enrich far under function differ glutam aspart idp remain poor understood studi examin differenti effect aspart glutam idp compar function conform ensembl glutam aspart variant disord protein dss use rang assay includ interact studi nuclear magnet reson spectroscopi small angl x ray scatter molecular dynam simul first analyz sequenc rapid grow databas experiment verifi idp disprot show glutam enrich caus taxonomi bias idp analys local global structur properti well cell growth protein protein interact use model acid idp yeast three gluasp variant find gluasp variant support similar function global dimens variant differ bind affin popul local transient structur element specul local structur differ may play role function divers glutam support increas helic import fold bind aspart support extend structur form helic cap well play relev role eg transactiv domain ion bind
|
D064267;D007290
|
T123;T121;T116;T114
|
36,291,633
|
identif protein respons neuroprotect effect secretom deriv blood cell remot ischaem condit rat recent shown blood cell deriv secretom remot ischaem ric condit individu provid extern sourc neuroprotect studi identifi bioactiv compound total protein releas cell main strategi separ protein protein complex maintain nativ structur test bioactiv properti subsequ identifi downregul bioactiv protein uncov two bioactiv fraction compos protein protein peak unchang howev ric mediat decreas two peak compris seven protein increas one peak identifi haptoglobin focuss biolog activ protein found posit impact regul cellular metabol process increas biolog process relat acut phase respons inflamm ric treat sampl although identifi protein exert greatest cytoprotect addit studi need elucid particular function detail mechan action
|
D018696
|
T121;T169
|
36,291,632
|
recent progress deubiquitin enzym human plant pathogen fungi eukaryot cell larg number protein modifi ubiquitin lead proteasom degrad chang protein function protein ubiquitin process revers process call deubiquitin play import regulatori mechan cellular control deubiquitin catalyz deubiquitin enzym dub cystein proteas specif cleav ubiquitin ubiquitin substrat ubiquitin precursor past two decad compon differ dub famili found play import role human plant pathogen fungi given import dub fungal develop virul review concentr recent find new insight role dub differ fungal pathogen focus infect relat morphogenesi virul well role develop stress respons also summar dub mediat regulatori mechan process find allow us develop novel inhibitor control fungal pathogen
|
D025801;D057056
|
T123;T126;T116
|
36,291,631
|
human melanocortin receptor identifi role residu tm ec tm domain activ traffick result co express accessori protein mrap chines hamster ovari cell human melanocortin receptor hmcr co express accessori protein mous mrap chines hamster ovari cho cell use model system investig activ traffick hmcr previous studi shown n termin domain mmrap make contact one extracellular domain hmcr facilit activ hmcr chimer receptor paradigm use extracellular domain hmcr replac correspond domain xenopus tropicali mcr receptor interact mrap reveal ec extracellular domain like contact site hmcr mmrap facilit activ receptor follow acth bind event prior activ mmrap facilit traffick hmcr er plasma membran process depend transmembran domain tm mmrap make contact one tms hmcr singl alanin substitut paradigm use identifi residu tm ie ec f tm f play role traffick hmcr plasma membran result provid clarif activ mechan hmcr
|
D044103;D000324
|
T125;T121;T116;T192
|
36,291,630
|
effect nitrogen concentr biosynthesi citric acid protein lipid yeast yarrowia lipolytica yarrowia lipolytica yeast well known abl synthes citric acid ca larg amount studi deal ca biosynthesi product biomass well accumul composit protein lipid lipolytica vkm grown media glucos differ concentr ammonium sulfat gl found concentr nitrogen sourc limit growth lipolytica nitrogen defici main caus ca excret high concentr nh gl accumul cell biomass biomass yield yxs protein concentr higher medium gl ammonium sulfat time time respect ca accumul meaning quantiti media contain gl nh maximum concentr ca gl gl ammonium sulfat also interest technolog mode gl nh character high product gl h note biomass contain larg amount essenti amino acid unsatur fatti acid use food biotechnolog agricultur
|
D025062
|
T004
|
36,291,629
|
mitophagi new target bone diseas bone diseas usual caus abnorm metabol death cell bone includ osteoblast osteoclast osteocyt chondrocyt bone marrow mesenchym stem cell mitochondri dysfunct import caus abnorm cell metabol wide involv occurr progress multipl bone diseas includ osteoarthr intervertebr disc degener osteoporosi osteosarcoma select mitochondri autophagi damag dysfunct mitochondria mitophagi close relat mitochondri qualiti control homeostasi accumul evid suggest mitophagi play import regulatori role bone diseas indic regul level mitophagi may new strategi bone relat diseas therefor review relev literatur recent year paper review potenti mechan mitophagi bone relat diseas includ osteoarthr intervertebr disc degener osteoporosi osteosarcoma provid theoret basi relat research mitophagi bone diseas
|
D055959;D012516;D010003;D010024
|
T047;T191;T190
|
36,291,628
|
system biomark uniqu pathway differ phenotyp heart failur preserv eject fraction heart failur preserv eject fraction hfpef account around heart failur case heterogen condit poor understood pathogenesi aim identifi uniqu pathogen mechan acut chronic hfpef hypertroph cardiomyopathi hcm perform unbias comprehens proteom analys plasma sampl gender bmi match patient acut hfpef n chronic hfpef n hcm n use liquid chromatographi mass spectrometri distinct molecular signatur observ differ hfpef form cluster biomark differenti abund hfpef form predomin associ microvascular inflamm new candid protein marker also identifi includ leucin rich alpha glycoprotein lrg serum amyloid saa inter alpha trypsin inhibitor heavi chain itih studi first appli systemat quantit proteom screen plasma sampl patient differ subtyp hfpef identifi candid biomark improv manag acut chronic hfpef hcm
|
D006333
|
T047;T046
|
36,291,627
|
statin allevi tumor hypoxia prostat cancer model decreas oxygen consumpt opportun radiosensit statin found decreas oxygen consumpt rate ocr varieti normal cell hypothesi statin may also decreas ocr cancer cell allevi tumor hypoxia radiosensit tumor
|
D019161;D011471
|
T121;T191;T109
|
36,291,626
|
next generat sequenc gene panel inherit cardiomyopathi channelopathi preval pathogen variant variant unknown signific uncommon gene diffus next generat sequenc ngs base approach allow identif pathogen mutat cardiomyopathi channelopathi differ gene sinc gene consid uncommon clinic phenotyp also includ molecular test detect rate diseas caus variant increas report preval genet variant detect use ngs custom panel cohort patient inherit cardiomyopathi n channelopathi n identifi variant identifi gene without strong definit evid diseas associ accord nih fund clinic genom resourc clingen uncommon gene among variant unknown signific vuss pathogen p like pathogen lp mutat benign b like benign lb variant accord american colleg medic genet acmg classif data reinforc need screen uncommon gene order increas diagnost sensit genet test inherit cardiomyopathi channelopathi allow identif mutat gene usual explor due current poor associ clinic phenotyp
|
D053447;D009202
|
T047
|
36,291,625
|
use oliv sunflow oil hydrogel emuls pork fat replac goat meat burger fat reduct effect lipid qualiti diversifi strategi incorpor healthier lipid process meat product develop altern fat sourc replac anim fat associ reduct fat content method use obtain healthier meat product well recogn consum order creat healthier product also consum halal kosher consum market experiment studi develop assess effect replac pork fat amount hydrogel emuls incorpor oliv oil sunflow oil three burger random select lot manufactur analyz triplic burger physicochem analyz ph water activ composit fatti acid profil color yield textur oxid stabil volatil compound compar accord fat sourc burger hydrogel emuls consid reduc fat meat product healthier fatti acid profil pork fat burger use hydrogel emuls negat affect qualiti characterist assess product improv oxid stabil storag cook burger characterist formul evalu replac pork fat oliv oil hydrogel emuls prove effect strategi obtain healthier goat meat product
|
D008461;D031658;D000080305;D000069466
|
T168;T002
|
36,291,624
|
inhibit malat dehydrogenas protect renal tubular epitheli cell anoxia reoxygen induc death senesc ischemia reperfus injuri lead caus acut kidney injuri reactiv oxygen speci ros product caus cell death senesc cultur primari human renal tubular epitheli cell rptec subject anoxia reoxygen inhibit kreb cycl level malat dehydrogenas mdh decreas hypoxia induc factor oxid stress protect apoptot ferroptot cell death inhibit mdh decreas reoxygen induc upregul p p restor level prolifer marker ki prevent upregul senesc marker beta galactosidas interleukin product mdh inhibit reduc reoxygen induc upregul atp alter critic cell metabol enzym allow enough atp product prevent cell energi collaps thus inhibit kreb cycl level mdh protect rptec anoxia reoxygen induc death senesc mdh may promis pharmaceut target ischemia reperfus injuri
|
D051795;D008291;D015427
|
T123;T126;T116;T037
|
36,291,623
|
mitochondria central nervous system disord mitochondria semi autonom membran bound organell present cytoplasm near eukaryot cell
|
D008928;D002493
|
T026;T047;T043
|
36,291,622
|
flow simul gradient print fluorapatit cell load recombin spider silk hydrogel hierarch structur abund almost tissu human bodi therefor high import tissu engin approach mimic structur gain function new tissu intend hierarch structur call enthesi gradient tissu locat tendon bone focus bridg mechan properti soft hard secur perfect forc transmiss muscl skeleton upon locomot studi aim novel method bioprint generat gradient biomateri construct focus evalu gradient print process first numer approach use simul gradient format comput flow prerequisit experiment bioprint gradient hydrogel print singl cartridg print set transfer find biomed relev materi first composit recombin spider silk hydrogel fluorapatit rod use generat miner gradient fibroblast encapsul recombin spider silk fluorapatit hydrogel gradual print use unload spider silk hydrogel second compon therebi adjust gradient featur achiev multimateri construct generat process suitabl generat gradient materi eg tissu engin applic tendonbon interfac
|
D047011;D020100
|
T123;T122;T121;T116
|
36,291,621
|
search metabol signatur cancer review warburg time review focus evolv understand tumor cell metabol particular glycolyt oxid metabol trace back evolut time understand develop sinc pioneer work otto warburg understand tumor cell metabol continu hamper misinterpret work contribut use new concept metabol switch metabol reprogram step realiti warburg effect often consid hallmark cancer realli general metabol signatur cancer draw conclus signatur cancer reduc singl factor express tissu level term capac cell dynam explor vast metabol landscap context signific environment heterogen
|
D009369
|
T191
|
36,291,620
|
model reactiv oxygen speci induc axon loss leber hereditari optic neuropathi leber hereditari optic neuropathi lhon rare syndrom result vision loss necessari suffici condit onset exist known mitochondri dna mutat affect complex biomolecular structur cybrid lhon mutat generat higher rate reactiv oxygen speci ros studi model ros particular ho could signal execut axon degener process under lhon model explor sever hypothes regard influenc ho dynam propag axon degener lhon zonal oxid stress correspond ho gradient correl morpholog injuri exhibit lhon patholog axon membran high permeabl ho oxid stress induc larger product ho small injuri could trigger cascad failur neighbor axon cellular interdepend creat ho diffus gradient creat tissu variat ho product scaveng result injuri pattern surviv axon loss distribut similar lhon tissu sampl specif axon degener start tempor optic nerv larger group small diamet fiber locat propag region find correl well clinic observ central loss visual field visual acuiti color vision lhon may serv silico platform model mechan action new therapeut
|
D029242
|
T047
|
36,291,619
|
rosmarin acid relat dietari supplement potenti applic prevent treatment cancer cancer constitut sever threat human health qualiti life one signific caus morbid mortal worldwid natur dietari product drawn substanti attent cancer treatment prevent due avail absenc toxic rosmarin acid ra known excel antioxid properti safe effect prevent inhibit tumor review summar recent public cultur techniqu extract process anti tumor applic ra enrich dietari supplement discuss techniqu improv ra bioavail provid mechanist discuss ra regard tumor prevent treatment adjuv therapi ra exhibit anticanc activ regul oxid stress chronic inflamm cell cycl apoptosi metastasi data suggest daili use ra enrich dietari supplement contribut tumor prevent treatment ra potenti applic anti tumor drug develop
|
D009369;D000970
|
T121;T191;T109
|
36,291,618
|
alzheim diseas challeng therapeut opportun treat neurotroph compound alzheim diseas ad progress neurodegen diseas insidi onset multifactori natur deficit neurogenesi synapt plastic consid earli patholog featur associ neurofibrillari tau amyloid patholog neuroinflamm imbal neurotroph factor increas fgf level decreas brain deriv neurotroph factor bdnf neurotrophin nt hippocampus frontal cortex pariet cortex disrupt brain micro environ characterist ad neurotroph factor crucial neuron differenti matur surviv sever attempt use neurotroph factor treat ad made trial halt due blood brain barrier bbb imperm short half life sever side effect present review main focus major etiopatholog featur ad use small neurotroph neurogen peptid mimet compound p discov laboratori found overcom difficulti face administr whole neurotroph factor protein describ pre clinic studi p potenti therapeut drug ad relat neurodegen disord studi limit focus p relev literatur thorough investig requir review studi various therapeut approach potenti drug emerg ad field
|
D000544;D019636
|
T047;T048
|
36,291,617
|
synergist effect plasma dickkopf obstruct coronari arteri diseas predict major advers cardiac event patient angina observ studi canon catenin depend wingless wnt pathway associ endotheli function examin effect plasma dickkopf dkk inhibitor wnt pathway predict major advers cardiac event mace enrol patient undergon select coronari angiographi angina dkk level determin use plasma collect outpati visit fast mace serv primari endpoint enrol patient divid four group accord median plasma dkk level presenc obstruct coronari arteri diseas cad forti eight patient reach primari endpoint median follow time year kaplan meier surviv analysi indic group high dkk obstruct cad signific higher mortal rate three group log rank test p compar low plasma dkk without signific coronari obstruct group high dkk obstruct cad group hazard ratio confid interv mace determin multivari cox proport hazard regress analysi conclus observ synergist effect high plasma dkk obstruct cad predict mace patient angina
|
D003324;D054059
|
T047
|
36,291,616
|
ligand melanocortin receptor beyond melanocyt stimul hormon adrenocorticotropin discoveri melanocortin result year research focus peptid extens studi elucid well establish function melanocortin mediat cell surfac receptor includ mshr melanocyt stimul hormon receptor acthr adrenocorticotropin receptor subsequ three addit melanocortin receptor mcrs identifi among five mcrs mcr mcr express primarili central nervous system therefor refer neural mcrs sinc central melanocortin system play import role regul energi homeostasi target neural mcrs emerg therapeut approach treat metabol condit obes cachexia earli effort modifi endogen ligand result develop mani potent select ligand review focus ligand neural mcrs includ classic ligand msh agouti relat peptid nonclass ligand lipocalin defensin small molecul pharmacoperon clinic approv ligand acth setmelanotid bremelanotid sever repurpos drug
|
D009074;D023083
|
T125;T121;T116
|
36,291,615
|
distinct cell repertoir nod mice weaken immun regul favor diabet diseas previous studi mice human suggest cell play role develop type diabet inconsist contradictori attempt resolv type diabet prone nod mice character cell popul investig function contribut particular cell subset use v gene target nod mice found evid nod v cell inhibit develop diabet process involv il product andor promot regulatori cd cell treg pancreat lymph node contrast nod v cell promot diabet develop enhanc v cell number nod mice particular bias produc ifn appear favor diabet diseas within nod mice defici particular cell subset note chang abund non target cell type also occur vari depend upon cell miss result indic certain cell subset inhibit develop spontan type diabet other exacerb may via mechan includ alter level cell
|
D016692;D003922
|
T129;T047;T116;T192
|
36,291,614
|
credibl role curcumin oxid stress mediat mitochondri dysfunct mammal oxid stress mitochondri dysfunct associ pathogenesi sever human diseas excess generat reactiv oxygen speci ros andor lack adequ antioxid defens caus dna mutat mitochondria damag mitochondri respiratori chain alter membran permeabl mitochondri defens mechan alter link develop numer diseas curcumin activ ingredi turmer plant rhizom exhibit numer biolog activ ie antioxid anti inflammatori anticanc antimicrobi recent year mani research shown evid curcumin abil reduc oxid stress mitochondri dysfunct associ diseas review discuss curcumin antioxid mechan signific oxid stress reduct suppress mitochondri dysfunct mammal also discuss research gap give opinion curcumin research mammal proceed move forward
|
D003474
|
T121;T130;T109
|
36,291,613
|
reshap bind pocket neurotransmitt solut symport nss famili transport slca atb select reduc access cation amino acid deriv slca atb uniqu among slc protein abil transport proteinogen dipolar cation amino acid natur occur synthet analogu includ anti viral prodrug nitric oxid synthas nos inhibitor slca mediat amino acid uptak multipl cell type increas express associ pathophysiolog condit includ cancer investig key posit within core leut fold structur slca influenc substrat specif homolog model sequenc analysi identifi transmembran domain residu v equival posit known influenc substrat specif distant relat slc slc amino acid transport slca without v mutat heterolog express function determin radiotrac solut uptak electrophysiolog measur transport associ current substitut amino acid residu occupi slca posit modifi bind pocket environ select disrupt transport cation dipolar amino acid relat nos inhibitor understand molecular basi amino acid transport substrat specif improv knowledg multi function transport target leut fold facilit divers function among slc famili slc amino acid transport
|
D000596;D011355
|
T120;T123;T121;T116
|
36,291,612
|
synapt plastic predict spatiotempor fire rate pattern robust vivo like variabl synapt plastic experi induc chang connect neuron under learn memori brain understand synapt plastic deriv vitro experi precis repeat stimulus pattern howev neuron exhibit signific variabl vivo repeat experi spatial pattern synapt input dendrit tree influenc synapt plastic yet consid synapt plastic rule investig spatiotempor synapt input pattern produc plastic vivo like condit use data driven comput model plastic rule base calcium dynam use vivo spike train record input differ size cluster spine show plastic strong robust trial trial variabl spike time addit deriv general synapt plastic rule describ spatiotempor pattern synapt input control magnitud direct plastic synaps strong potenti greater fire rate calcium concentr later trial wherea strong depress synaps hire fire rate earli trial neighbor synapt activ influenc direct magnitud synapt plastic small cluster spine produc greatest increas synapt strength togeth result reveal calcium dynam unifi divers plastic rule reveal spatiotempor fire rate pattern control synapt plastic
|
D008959;D002118
|
T121;T123;T196;T170
|
36,291,611
|
role prostaglandin nitric oxid induc glial cell mediat vasodil rat retina previous identifi deriv neuron cell act glial cell caus vasodil healthi rat retina via releas epoxyeicosatrieno acid eet prostaglandin pgs activ arachidon acid cascad howev clear pg type involv respons aim present studi identifi prostanoid receptor involv glial cell deriv vasodil induc rat retina male wistar rat use examin effect intravitr pretreat indomethacin cyclooxygenas inhibitor pf prostanoid ep receptor antagonist cay prostanoid ip receptor antagonist chang retin arteriolar diamet induc intravitr administr donor retin arteriolar diamet measur use ocular fundus imag captur high resolut digit camera vivo increas retin arteriolar diamet induc intravitr inject signific suppress intravitr pretreat indomethacin pf cay dose pf cay inject intravitr present studi signific reduc increas retin arteriolar diamet induc prostaglandin e pge prostaglandin pgi respect result suggest activ arachidon acid cascad subsequ stimul prostanoid ep receptor involv rat retin vasodilatori respons evok induc glial cell stimul therefor glial cell deriv pge similar eet may play import role retin vasodilatori mechan
|
D014664;D011453
|
T125;T121;T109;T042
|
36,291,610
|
label free quantit proteom analysi adriamycin select multidrug resist human lung cancer cell develop drug resist lung cancer major clinic challeng lead year surviv rate therefor unravel mechan drug resist develop novel therapeut strategi crucial import studi systemat explor novel biomark drug resist use lung cancer model dlkp seri drug resist variant depth label free quantit mass spectrometri base proteom gene ontolog analysi show parent dlkp cell signific differ drug resist variant cellular proteom chang even among drug resist subpopul overal abc transport protein lipid metabol determin play signific role format drug resist dklp cell seri membran relat protein hmox tmb ephx neu identifi correl level drug resist dlkp subpopul studi also show enrich biolog process molecular function drug metabol cellular respons drug drug bind gene ontolog analysi protein determin posit negat correl resist level overal protein potenti therapeut diagnost valu identifi
|
D004317;D008175
|
T121;T191;T195;T109
|
36,291,609
|
perform serum angiotensin convert enzym diagnos sarcoidosi predict activ status sarcoidosi meta analysi use serum angiotensin convert enzym sace diagnos sarcoidosi determin activ status sarcoidosi report vari outcom basi major publish data conduct meta analysi calcul overal predict accuraci sace sarcoidosi diseas activ status sarcoidosi inclus relat research list web scienc pubm scopus literatur databas assess sroc curv generat character overal test result data sensit specif posit likelihood ratio plr negat likelihood ratio nlr diagnost odd ratio dor combin public bias identifi use deek funnel plot thirti five public subject met inclus criteria follow summari estim sace diagnost perform sarcoidosi sensit confid interv ci specif ci plr ci nlr ci dor ci area sroc curv auc ci summari estim predict activ status sarcoidosi follow sensit ci specif ci plr ci nlr ci dor ci auc ci evid public bias meta analysi suggest measur sace may assist diagnosi sarcoidosi predict activ status sarcoidosi interpret sace result caution futur studi valid result
|
D012507;D007703
|
T129;T047;T126;T116
|
36,291,608
|
peripher neutrophil lymphocyt ratio bronchiectasi marker diseas sever patient bronchiectasi predomin neutrophil inflammatori profil although cell lymphocyt control bronchial inflamm eosinophil also play signific pathophysiolog role easi interpret blood biomark discrimin capac sever prognosi need object studi assess whether peripher neutrophil lymphocyt ratio nlr associ differ outcom sever bronchiectasi total patient bronchiectasi spanish registri bronchiectasi includ compar group sampl divid increas quartil nlr ratio correl quantit variabl establish use pearson p test simpl linear regress valu exacerb quantit variabl use determin independ relationship number sever exacerb nlr ratio area curv auc roc use determin predict capac nlr sever bronchiectasi accord differ multidimension score mean age year women mean nlr higher nlr associ sever bronchiectasi especi signific discrimin power sever form accord common use score face e face bsi well poorer qualiti life sgrq comorbid charlson index infect pathogen microorgan greater applic treatment furthermor nlr correl better sever score paramet system inflamm final independ predictor incid number sever exacerb conclus nlr inexpens easi measur marker system inflamm determin sever predict exacerb especi sever patient bronchiectasi
|
D009504;D001987
|
T047;T025
|
36,291,607
|
cholinesteras defici syndrom pitfal use butyrylcholinesteras biomark wilson diseas famili describ two recess inherit metabol diseas three differ affect children explant drain tube grommet general anesthesia prolong resuscit wake period occur key case year old led famili screen butyrylcholinesteras defici confirm key case also year old sister confirm year old brother howev key case reduc serum level bche also elev liver enzym level atyp bche defici exclus viral autoimmun hepat wilson diseas wd eventu diagnos also confirm elder brother sister famili present highlight extrem rare wd patient low serum level bche occur wd bche defici
|
D006527
|
T047
|
36,291,606
|
effect classic tspo ligand pk vitro cobalt chlorid model hypoxia like condit lung brain cell line mitochondri transloc protein tspo modul apoptot pathway involv reactiv oxygen speci ros generat mitochondri membran potenti collaps activ caspas eventu initi apoptot process vitro studi h lung cell bv microgli cell expos hypoxia like effect cocl without pk expos h cell mm cocl h result decreas cell viabil p amp lt elev cardiolipin peroxid level p amp lt mitochondri membran potenti depolar p amp lt apoptot cell death p amp lt pretreat pk exhibit signific protect capac cocl induc alter mention process exposur bv cell increas concentr cocl mm h result alter cellular process alter obtain dose depend manner except chang caspas novel ligand well pk attenu vitro hypoxia like effect cocl appear tspo ligand pk prevent cocl induc cellular damag non neuron brain cell line may offer novel approach treatment hypoxia relat lung brain diseas case fail respond convent therapi
|
D002308;D017209
|
T123;T043;T116;T109
|
36,291,605
|
caenorhabd elegan model studi manganes induc neurotox caenorhabd elegan c elegan nematod present worldwid worm show homolog mammalian system express approxim human diseas relat gene sinc dr sydney brenner first propos c elegan advantag experiment worm model system genet approach increas number studi use c elegan tool investig topic sever field biochemistri neurosci pharmacolog toxicolog perform regard c elegan use character molecular mechan affect pathway caus metal lead neurotox well pathophysiolog interrelationship metal exposur ongo neurodegen disord sever toxic metal lead cadmium mercuri recogn import environment contamin exposur associ toxic effect human bodi essenti element requir maintain cellular homeostasi normal physiolog function may also toxic accumul higher concentr instanc manganes mn trace essenti element particip numer biolog process enzymat activ energi metabol mainten cell function howev mn overexposur associ behavior chang c elegan consist dopaminerg system primari target mn neurotox caenorhabd elegan shown import tool allow studi neuron morpholog use fluoresc transgen worm moreov behavior test may conduct use worm neurotransmitt determin relat gene express like chang mn exposur likewis mutant worm may use studi molecular mechan mn toxic well express protein respons biosynthesi transport storag uptak dopamin furthermor review highlight advantag limit use experiment model c elegan provid guidanc potenti futur applic model studi direct toward assess mn neurotox relat mechan
|
D029742;D008628
|
T131;T196;T116
|
36,291,604
|
comput dissect role trp regul death associ protein kinas calmodulin interact death associ protein kinas dapk calciumcalmodulin cam regul serinethreonin kinas function apoptot autophagi pathway repres interest drug target inflammatori bowel diseas alzheim diseas crystal structur dapk catalyt domain autoregulatori domain ard complex cam provid understand cam depend regul dapk activ howev molecular basi distinct trp wy wd mutat ard modul differ dapk activ remain unknown perform multipl length molecular dynam md simul dapk cam complex three differ wild type wy wd state md simul show overal structur complex chang signific wild type wy system underw obvious conform alter wd system dynam cross correl princip compon analys reveal wd mutat enhanc anti correl motion dapk cam sampl broader distribut conform space relat wild type wy system structur energet analys exhibit cam bind unfavor respons wd mutat result decreas bind cam wd mutant furthermor hydrogen bond salt bridg respons loss cam bind interfac dapk cam complex identifi wd mutant result may provid insight key role trp regul cam mediat dapk activ
|
D002147;D002118
|
T123;T196;T121;T116
|
36,291,603
|
leverag structur dnaja discov novel potenti pancreat cancer therapi pancreat cancer remain one deadliest form cancer year surviv rate difficult diagnosi limit treatment option major caus poor outcom pancreat cancer human protein dnaja propos potenti therapeut target pancreat cancer cellular biolog function remain unclear previous studi suggest dnaja cellular activ may depend upon protein bind partner investig assert first amino acid structur dnaja solv nmr includ classic j domain associ linker region propos vital dnaja function dnaja nmr structur use identifi protein ligand bind site potenti bind partner may suggest intracellular role dnaja virtual drug screen follow nmr isotherm titrat calorimetri identifi drug like compound bind two differ site dnaja pull assay identifi potenti novel protein bind partner dnaja protein conjunct previous publish metabolom studi support vital role dnaja cellular oncogenesi pancreat cancer
|
D050956;D010190
|
T123;T191;T116
|
36,291,602
|
insight role leptin bridg obes breast cancer leptin peptid hormon main known role mediat adipos tissu endocrin function appetit control energi homeostasi addit leptin signal involv sever physiolog process modul innat adapt immun respons regul sex hormon level adipos tissu expand imbal adipokin secret may occur increas leptin level contribut promot chronic inflammatori state larg acknowledg hallmark cancer inde upon bind receptor lepr leptin activ sever oncogen pathway jakstat mapk pikakt seem affect cancer immun respons induc proinflammatori immun polar eventu enhanc cell exhaust particular obes associ hyperleptinemia relat breast cancer risk develop although under mechan yet complet clarifi need deem light multipl variabl menopaus state immun respons aim review provid overview potenti role leptin bridg obes breast cancer establish physio patholog basi linkag major health concern order identifi appropri novel therapeut strategi adopt daili clinic practic
|
D020738;D001943
|
T125;T191;T116
|
36,291,601
|
molecular pathogenesi cardiac arrhythmia heart necessari organ sustain life mammal first organ function earli develop
|
D001145;D006321
|
T047;T023
|
36,291,600
|
molecular genet basi plant breed tradit plant breed improv signific applic molecular genet approach
|
D000069600;D010944
|
T040;T002
|
36,291,599
|
use visual electrophysiolog monitor retin optic nerv toxic import clinician consid exposur toxic substanc nutrit defici diagnos manag case vision loss case physiolog damag alter function key compon visual pathway morpholog chang detect tradit imag method electrophysiolog test aid earli detect function chang visual pathway compon includ retina optic nerv review provid overview various electrophysiolog techniqu includ multifoc electroretinogram mferg full field erg fferg electrooculogram eog pattern electroretinogram perg visual evok potenti vep monitor retin optic nerv toxic alcohol amiodaron cefuroxim cisplatin deferoxamin digoxin ethambutol hydroxychloroquin isotretinoin ocular siderosi pentosan pde inhibitor phenothiazin chlorpromazin thioridazin quinin tamoxifen topiram vigabatrin vitamin defici
|
D005074;D000638
|
T121;T109;T042
|
36,291,598
|
activ wnt catenin signal involv nm laser radiat epithelium modul lipid metabol research proven light treatment specif red light radiat provid clinic benefit human health investig first conduct character tissu morpholog mous breast post nm laser radiat low power long term exposur rna sequenc result reveal light exposur higher intervent dosag could caus number differenti express gene compar low intervent dosag gene ontolog analysi protein protein interact network analysi gene set enrich analysi result suggest nm light exposur activ transcript relat pathway hc breast epitheli cell pathway may involv modul critic gene express consid critic role wntt catenin pathway light induc modul hypothes pathway might play major role respons nm light exposur valid hypothesi conduct qrt pcr immunofluoresc stain western blot assay relat result corrobor laser radiat could promot express level catenin relat phosphoryl signific chang metabolit pathway analysi reveal nm laser could affect nucleotid metabol regul purin metabol find suggest wnt catenin pathway may major sensor nm laser radiat may help rescu drawback side effect nm light exposur relat intervent agent
|
D051176;D050356
|
T123;T116;T044
|
36,291,597
|
character novel pectinolyt enzym deriv effici lignocellulos degrad microbiota divers pectinolyt enzym wide appli food papermak industri account global industri enzym demand effici lignocellulos degrad microbiota reservoir pectinolyt enzym lignocellulos degrad gene metagenom wide use discov new pectinolyt enzym use metagenom strategi character pectinolyt gene one effici lignocellulos degrad microbiota deriv pulp paper wastewat treatment microbiota total predict full length gh pl famili pectinolyt gene select clone express escherichia coli express protein pectinolyt activ among character one pectinolyt enzym pw pgh ident exo polygalacturonas gene aquipluma nitroreducen investig optim ph optim temperatur pw pgh c respect pectinolyt activ optim condit umg protein bioinformat analys structur model suggest pw pgh novel secretori exo polygalacturonas confirm hydrolys polygalacturon acid detect pw pgh pectinolyt gene show effici lignocellulos degrad microbiota could provid potenti effici pectinolyt enzym industri applic futur improv metagenom screen effici would discov effici lignocellulos degrad enzym lead sustain green util lignocellulos
|
D011096;D064307
|
T032;T116;T126;T028;T001
|
36,291,596
|
multicellular effect vdac n termin deriv peptid mitochondri voltag depend anion channel vdac protein function varieti mitochondria link physiolog patholog process includ metabol cell signal well mitochondria mediat apoptosi vdac interact protein regul integr mitochondri function cellular activ recent develop vdac base peptid multipl effect cancer cell tumor includ apoptosi induct design sever cell penetr vdac n termin deriv peptid goal identifi shortest peptid improv cellular stabil activ identifi n ter antp compris vdac n termin region amino acid fuse antp cell penetr peptid demonstr peptid induc apoptosi autophagi senesc cell volum enlarg refus divid daughter cell singl cell respons reorgan actin tubulin filament increas cell adhes addit peptid induc alter express protein associ cell metabol signal divis enhanc express nuclear factor kappa b decreas express nuclear factor kappa light polypeptid gene enhanc b cell inhibitor alpha cellular effect may result peptid interf vdac interact interact protein therebi block multipl mitochondrialvdac pathway associ cell function result studi support role vdac mitochondri gatekeep protein control varieti cell function via interact associ protein
|
D057846
|
T116
|
36,291,595
|
select multitarget peptid alzheim diseas alzheim diseas ad multifactori diseas complex pathogenesi develop multitarget drug could power strategi impact progress loss cognit function diseas purpos studi select multitarget lead peptid candid among seri peptid variant deriv neutrophil granul protein cathepsin g screen eight peptid candid use follow criteria inhibit revers amyloid beta oligom quantifi use enzym link immunosorb assay elisa direct bind peptid candid human receptor advanc glycat end product rage toll like receptor tlr calcium bind protein sa quantifi elisa protect oligom induc neuron cell death use trypan blue measur cell death murin neuron cell line inhibit tlr activ sa use human tlr report cell line select mer lead peptid fulfil four criteria lead peptid privileg structur display inher multitarget activ peptid expect signific impact cognit declin mous model alzheim diseas target neuroinflamm neurodegener
|
D000544
|
T047;T048
|
36,291,594
|
calcium permeabl channel cooper rheumatoid arthriti therapeut opportun rheumatoid arthriti common autoimmun diseas result deposit antibodi autoantigen joint lead long last inflamm main featur ra includ cartilag damag synovi invas flare up intra articular inflamm patholog process signific reduc patient qualiti life date still drug target act rheumatoid arthriti therefor search novel drug target becom urgent due uniqu physicochem properti calcium ion play import role cellular activ bodi evolv rigor calcium signal system calcium permeabl channel main oper calcium signal wide distribut cell membran endoplasm reticulum membran mitochondri membran mediat efflux entri ca last centuri calcium permeabl channel identifi human cell role larg famili calcium permeabl channel rheumatoid arthriti gradual becom clear review briefli introduc major calcium permeabl channel involv pathogenesi ra eg acid sensit ion channel asic transient receptor potenti trp channel px receptor explain specif role mechan calcium permeabl channel pathogenesi ra provid comprehens idea target treatment ra
|
D001172;D050051
|
T123;T047;T116
|
36,291,593
|
galectin potenti biomark eosinophil diseas galectin member lectin famili one abund cytoplasm protein human eosinophil except myeloid leukemia cell basophil minor cell popul galectin exclus present eosinophil human bodi galectin form charcot leyden crystal observ various eosinophil diseas accumul studi indic galectin act new biomark diseas activ diagnosi treatment effect asthma eosinophil esophag rhiniti sinus atop dermat eosinophil granulomatosi polyangi extracellular releas galectin mediat convent secretori process piecem degranul exocytosi rather extracellular trap cell death etosi activ cell death program eosinophil undergo etosi rapid disintegr plasma membran releas major galectin therefor elev galectin level serum tissu suggest high degre eosinophil etosi date sever studi shown galectin charcot leyden crystal marker eosinophil inflamm play function role immun review focus close relationship eosinophil galectin highlight protein potenti new biomark eosinophil diseas
|
D015267;D014890
|
T047
|
36,291,592
|
mutat signatur sensor environment exposur analysi smoke induc lung tissu remodel smoke wide recogn risk factor emerg cancer lung diseas studi non cancer lung diseas typic investig role smoke chronic chang lung might predispos patient diseas wherea cancer studi focus mutagen properti smoke larg scale cancer analysi effort collect express data tumor control lung tissu studi use control sampl estim impact smoke gene express howev analys may confound tumor relat micro environ well patient specif exposur smoke thus paper explor util mutat signatur studi environ induc chang gene express control lung tissu lung adenocarcinoma sampl show joint comput analysi mutat signatur deriv sequenc tumor sampl gene express obtain control sampl shed light combin impact smoke tumor relat micro environ gene express cell type composit non neoplast control lung tissu result obtain analysi support experiment studi includ studi util singl cell technolog also suggest addit novel insight argu studi provid proof principl util mutat signatur use sensor environment exposur context mutat landscap cancer also refer chang non cancer lung tissu also provid exampl databas collect purpos understand cancer provid valuabl inform studi direct relat diseas
|
D009369;D008171;D008175
|
T047;T191
|
36,291,591
|
heterogen clinic phenotyp dhmn caus mutat hspb gene case seri mutat hspb known caus charcot mari tooth diseas type f cmtf distal hereditari motor neuropathi dhmn studi present three patient mutat hspb diagnos dhmn proband year old male progress bilater lower limb weak walk difficulti four year proband year old male chronic lower limb weak restless leg syndrom age proband year old femal progress weak lower limb atrophi age nerv conduct studi ncs suggest axon degener peripher motor nerv needl electromyographi emg reveal chronic neurogen chang proband open sural nerv biopsi proband mother proband show mild moder loss myelin nerv fiber nerv fiber regener novel pvl hspb identifi proband two variant ppa prw hspb report previous function studi show express mutant pvl hspb sh syy cell display decreas cell activ increas apoptosi stress condit studi expand clinic phenotyp spectrum etiolog spectrum hspb mutat
|
D009447;D002607
|
T047;T191
|
36,291,590
|
valid commerci enzym link immunosorb assay allopregnanolon saliva healthi pregnant women enzym link immunosorb assay elisa saliva simpl non invas method hormon detect allopregnanolon allo neuroact steroid hormon play crucial role aetiolog reproduct mood disord better understand relationship allo mood valid method measur peripher hormon level requir current commerci avail elisa measur allo saliva valid two elisa develop use blood saliva sampl pregnant women examin rang sensit intra inter assay precis parallel linear dilut recoveri sampl simultan analys use liquid chromatographi mass spectrometri lc ms method kit differ rang pgml vs ngml sensit amp lt pgml vs ngml latter show signific matrix effect former fulfil accept criteria paramet concentr measur lc ms lower limit quantif amp lt ngml signal detect one test elisa valid method detect allo saliva pregnant women suitabl measur rang higher sensit convent lc ms method
|
D012463;D000081227
|
T123;T109;T031
|
36,291,589
|
protein involv plant dehydr protect late embryogenesi abund famili plant evolv number differ way deal differ type abiot stress molecular level dehydr caus multipl form damag differ biomolecul
|
D018506;D010940
|
T045;T116
|
36,291,588
|
volumetr analysi glioblastoma determin cpg site test pyrosequenc predict temozolomid efficaci aim present studi determin individu combin cpg site among methylguanin dna methyltransferas cpg glioblastoma main affect respons temozolomid result cpg methyl use statist analys focus tumor volum ratio tvr retrospect examin patient postop volumetr measur residu tumor tissu receiv adjuv temozolomid therapi least month initi chemoradiotherapi tvr defin tumor volum month initi chemoradiotherapi divid start chemoradiotherapi predict valu tvr respons adjuv therapi compar among averag methyl percentag individu combin cpgs use receiv oper characterist curv data reveal combin cpg show high area curv auc posit likelihood ratio combin cpg show highest auc among combin auc consecut cpg combin tend higher cpg exon cpg intron conclus methyl status cpg site exon strong associ tvr reduct glioblastoma
|
D005909;D001932
|
T191
|
36,291,587
|
pan cancer analysi heat shock protein beta hspb human tumour hspb member heat shock protein famili play vital role molecular chaperon oncogen stimul tumour growth howev role various cancer remain unexplor
|
D002295;D001749;D002292;D007680
|
T191
|
36,291,586
|
role cell cell junction oesophag squamous cell carcinoma cell cell junction compris various structur includ adheren junction tight junction desmosom gap junction link cell tissu regul tissu homeostasi critic cellular process recent advanc cell cell junction research led critic discoveri cell cell adhes compon import invas metastasi tumour cell relat cell cell adhes chang also involv critic molecular signal pathway great signific especi given relev molecular mechan discov increas number emerg biomark target therapi becom futur therapeut concern increas number therapeut agent undergo clinic trial oesophag squamous cell carcinoma escc common histolog subtyp oesophag cancer one common cancer affect epitheli tissu escc progress accompani abnorm express localis compon cell cell junction review discuss recent scientif develop relat molecul cell cell junction role escc offer valuabl insight reader provid global view relationship posit construct function give refer futur mechanist studi diagnos therapeut develop
|
D000077277;D004938
|
T191
|
36,291,585
|
radiobiolog aspect flash radiotherapi radiotherapi rt one primari treatment modal cancer patient clinic use rt requir balanc struck tumor effect risk toxic spare normal tissu cornerston reduc toxic advanc physic target dose shape technolog help achiev flash rt promis novel treatment techniqu seek exploit potenti normal tissu spare effect ultra high dose rate irradi signific bodi vitro vivo data highlight decreas acut late radiat toxic preserv radiat effect tumor cell under biolog mechan flash rt howev remain unclear three main mechan hypothes account differenti flash rt effect tumor healthi tissu oxygen deplet dna damag immun mediat hypothesi hypothes molecular mechan evalu vitro vivo furthermor effect ultra high dose rate radiat extrem short deliveri time dynam tumor microenviron involv circul blood cell immun cell human essenti unknown therefor great interest flash rt mean target tumor promis increas therapeut ratio evid general flash effect human data show flash human safe least effect tumor standard photon rt current lack flash rt need preclin investig well design human studi introduc clinic practic
|
D009369;D011832
|
T047;T191;T037
|
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