PMID
int64 35.7M
36.4M
| Title/Abstract
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|---|---|---|---|
36,291,584
|
elev extracellular hsp blunt heat shock respons sever covid patient hypothes critic ill patient sar cov infect insulin resist would present reduc heat shock respons hsr pathway involv proteostasi anti inflamm subsequ lead wors outcom higher inflamm work aim measur concentr extracellular hsp ehsp patient sever covid comparison noninfect patient ii compar hsr critic ill patient covid without diabet iii compar hsr patient noninfect individu
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D000086382;D003924
|
T047;T067
|
36,291,583
|
toxic essenti metal human health diseas special issu biomolecul call toxic essenti metal human health diseas repres follow previous special issu name toxic essenti metal human health diseas
|
D008670;D019216
|
T197;T196
|
36,291,582
|
role ion channel develop pulmonari arteri hypertens pulmonari arteri hypertens pah uncommon progress fatal diseas
|
D000081029;D006976
|
T047;T046
|
36,291,581
|
novel regulatori role hydrogen sulfid health diseas follow prof
|
D006862;D064426
|
T131;T197;T130;T123
|
36,291,580
|
transcriptom meta analysi confirm hidraden suppurativa pathogen triad upregul inflamm alter epitheli organ dysregul metabol signal hidraden suppurativa hs inflammatori skin condit clinic character recurr pain deep seat nodul abscess sinus track area bear apocrin gland axilla breast groin buttock despit mani recent advanc pathophysiolog landscap hs still demand clarif elucid hs pathogenesi perform meta analysi set analysi variant call select rna sequenc rna seq studi hs skin find corrobor hs triad compos upregul inflamm alter epitheli differenti dysregul metabol signal upregul specif gene krt krt serpin famili gene sprr confirm earli involv hair follicl impair barrier function hs lesion skin addit result suggest adipokin could regard biomark hs metabol relat disord final rna seq variant call identifi sever mutat hs patient suggest potenti new hs relat gene associ sporad form diseas overal studi provid insight molecular pathway involv hs identifi potenti hs relat biomark
|
D017497;D015843
|
T123;T047;T121;T116
|
36,291,579
|
delet growth hormon secretagogu receptor kisspeptin neuron femal mice block diet induc obes gut peptid ghrelin mediat energi homeostasi reproduct act receptor growth hormon secretagogu receptor ghsr express hypothalam neuron arcuat arc shown estradiol e increas ghsr express kisspeptinneurokinin bdynorphin kndi neuron enhanc sensit ghrelin hypothes e induc ghsr express augment kndi sensit fast state elev ghrelin disrupt energi expenditur femal produc kiss ghsr knockout determin role ghsr arc kndi neuron found chang arc gene express estradiol benzoat eb treatment abrog delet ghsr ghrelin abolish differ also observ chang metabol fast glucos level addit knockout resist bodi weight gain high fat diet hfd behavior found knockout hfd exhibit reduc anxieti like behavior furthermor knockout refe extent control h fast final respons cold stress knockout femal elev metabol paramet compar control data indic ghsr kiss neuron modul arc gene express metabol glucos homeostasi behavior thermoregul illustr novel mechan e ghrelin control kiss neuron
|
D054440
|
T116;T192
|
36,291,578
|
integr nanomet rang label label distanc distribut model approach label techniqu electron paramagnet reson spectroscopi singl molecul fluoresc reson energi transfer allow access distanc rang ten angstrom correspond size protein small medium size protein complex measur requir long rang order therefor applic system partial disord data spin label base measur process distanc distribut provid inform extent disord use inform model present sever challeng includ small number restraint influenc label measur distanc distribut width balanc fit qualiti long rang restraint fit qualiti restraint subset start general consider integr hybrid structur model review provid overview recent approach problem identifi progress need
|
D011506
|
T123;T116
|
36,291,577
|
matrix metalloproteinas glaucoma matrix metalloproteinas mmps enzym decompos extracellular matrix ecm protein mmps thought play import role cellular process cell prolifer differenti angiogenesi migrat apoptosi host defens mmps distribut almost intraocular tissu involv physiolog patholog mechan eye mmps also associ glaucoma progress neurodegen diseas eye mmp activ affect intraocular pressur control apoptosi retin ganglion cell patholog mechan glaucoma also affect risk glaucoma develop base genet pleomorph addit mmps may affect treatment outcom glaucoma includ success rate surgic treatment side effect ocular surfac due glaucoma medic review discuss various relationship mmp glaucoma
|
D019636;D005901
|
T047
|
36,291,576
|
local perivascular therapeut approach inhibit venous neointim hyperplasia arterioven fistula access hemodialysi use arterioven fistula avf prefer vascular access chronic hemodialysi high failur rate restrict use optim patient periop status surgic techniqu among method prevent primari avf failur continu fall short lower failur rate clinic practic one predomin caus avf failur neointim hyperplasia nih process result synergist effect inflamm hypoxia hemodynam shear stress vascular tissu although sever system therapi aim suppress nih none shown clear benefit toward goal local therapeut approach may improv rate avf matur provid direct structur function support matur fistula well deliv higher dose pharmacolog agent avoid advers effect associ system administr therapeut agent novel materi polymer scaffold nanoparticl enabl develop differ perivascular therapi support mechan devic target drug deliveri cell base therapeut review summar various perivascular therapeut approach avail data effect outlook local therapi target nih set avf hemodialysi use highlight system therapi improv avf patenc outcom therefor local therapeut approach may benefici local deliv drug medic devic may improv avf patenc outcom provid biolog mechan support cell base therapi shown promis suppress nih deliv extens array bioactiv substanc respons biochem chang avf microenviron
|
D006435;D001164
|
T061;T190
|
36,291,575
|
prostat cancer associ mirna saliva first step easili access reliabl screen tool common diagnost tool prostat cancer prostat specif antigen transrect biopsi show low predict valu poor sensit studi examin circul mirna saliva explor possibl non invas easi execut diagnost tool prostat cancer screen
|
D011471;D035683
|
T123;T191;T114
|
36,291,574
|
myricetin potenti adjuv chemotherapi studi inhibit human glutathion transferas glutathion transferas gsts famili phase ii detoxif enzym involv develop multi drug resist mdr phenomena toward chemotherapeut agent gst inhibitor consid candid compound abl chemomodul revers mdr natur flavonoid myricetin myr shown exhibit wide rang pharmacolog function includ antitumor activ present work interact myr human glutathion transferas hgsta investig kinet inhibit analysi molecular model studi result show myr bind high affin hgsta ic function non competit inhibitor toward electrophil substrat chloro dinitrobenzen cdnb competit inhibitor toward glutathion gsh chemic modif studi irrevers inhibitor phenethyl isothiocyan peitc combin silico molecular dock studi allow predict myr bind site myr appear bind distinct locat partial overlap gsh bind site g site result present studi show myr potent inhibitor hgsta exploit toward develop natur safe effect gst target cancer chemosensit
|
D005419;D005982
|
T121;T116;T127;T109;T126
|
36,291,573
|
cisplatin resist genet epigenet factor involv cisplatin cddp drug choic differ type cancer howev tumor cell acquir resist damag caus cisplatin generat genet epigenet chang lead generat resist activ intrins resist mechan cancer cell among find mutat altern splice epigenet driven express chang even post translat modif protein howev molecular mechan cddp resist develop clear believ multi factori articl highlight descript cisplatin includ action mechan resist epigenet factor involv cisplatin resist
|
D002945;D000970
|
T121;T197;T109
|
36,291,572
|
contagium vivum fluidum riboviria tobacco mosaic virus centric histori virus taxonomi virus discov agent diseas late th centuri natur agent elucid nevertheless soon viral diseas start recogn catalog attempt classifi name virus although earli attempt fail adopt nascent virolog communiti evid human compuls tri organ natur world well defin categori differ classif scheme propos th centuri none wide embrac virologist creation intern committe nomenclatur virus eventu renam intern committe taxonomi virus organ effort led offici taxonomi virus classifi famili genera present much better understand evolutionari relationship among virus led establish rank taxonomi base primarili evolutionari relationship review virus taxonomi center tobacco mosaic virus tmv agent diseas studi dmitri ivanovski first virus recogn often histor center major advanc virolog th centuri
|
D014027;D014780
|
T005
|
36,291,571
|
liposom entrap chemic modif relaxin prolong stabil biolog activ relaxin rlx protein structur similar insulin interest biolog activ protein preserv rlx structur integritybiolog function problemat herein investig two method increas durat relaxin rlx biolog activ synthesi palmitoyl rlx conjug p rlx use palmitoyl l glu otbu peptid modifi encapsul liposom p rlx rlx oxid form rlx liposom encapsul thin film hydrat drv method appli differ lipid composit test optim protein load rlx rlx quantifi hplc capabl peptidesconjug stimul transfect cell produc cyclic adenosin monophosph camp use measur biolog activ stabil bioactiv free liposom rlx type monitor period buffer case bovin serum c result show liposom encapsul substanti increas rlx integr buffer pegyl liposom demonstr higher protect liposom encapsul also increas stabil rlx rlx serum consid peptid biolog activ camp product rlx higher oxid form p rlx conjug demonstr similar activ rlx measur buffer lower measur presenc serum protein liposom encapsul result slight decreas bioactiv initi prolong peptid bioactiv incub serum conclud liposom encapsul rlx synthet modif p rlx prolong rlx peptid vitro stabil howev appli chemic conjug result signific loss bioactiv camp product wherea effect liposom entrap rlx activ signific lower
|
D012065;D061385
|
T125;T121;T116
|
36,291,570
|
glycosyl flavonoid compound potent cyp inhibitor mycobacterium tuberculosi due concern rise number multipl prolong drug resist mdr xdr mycobacterium tuberculosi mtb strain unpreced demand creat design develop novel therapeut drug higher efficaci safeti studi focus view implement silico drug design pipelin divers set glycosyl flavonoid screen mtb cytochrom p enzym cyp establish approv drug target treatment mtb infect total glycosyl flavonoid screen use structur base virtual screen crystal ligand ie l inhibitor bind pocket mtb cyp protein follow top six compound highest bind score kcalmol consid intermolecular interact dynam stabil use ns classic molecular dynam simul result suggest consider number hydrogen hydrophob interact thermodynam stabil comparison refer complex ie cyp l inhibitor furthermor bind free energi via mmgbsa method conduct last ns interv md simul trajectori reveal substanti affin glycosyl compound mtb cyp protein refer complex notabl dock pose residu energi decomposit via mmgbsa method demonstr essenti role activ residu interact glycosyl compound comparison refer complex collect studi demonstr viabil screen glycosyl flavonoid potenti inhibitor mtb cyp experiment valid develop therapi treatment drug resist mtb strain
|
D009169
|
T007
|
36,291,569
|
assess lipid qualiti commerci omega supplement sold french market supplement omega fatti acid consid valuabl strategi suppli low intak fatti acid thus safeti supplement import mileston analyz unflavor supplement sold french market fatti acid triglycerid composit epa dha tocol content well oxid status studi found supplement meet label claim omega content tag analysi show high variabl among triglycerid distribut trend also notic tocol content fact high variabl distribut six tocol four tocopherol two tocotrienol found among sampl test product compli peroxid valu p anisidin valu totox valu establish global organ epa dha omega go oxid
|
D024508;D015525
|
T121;T123;T127;T109
|
36,291,568
|
antipsychot drug fluphenazin human cancer cell drug repurpos strategi speed find novel clinic use alreadi approv drug sever diseas cancer process acceler compar develop new drug compound alreadi test clinic trial data relat pharmacokinet alreadi describ reduc cost time associ develop new anticanc therapeut sever studi suggest repurpos fluphenazin cancer therapi may promis approach drug prove reduc viabil divers cancer cell line review intens research literatur perform relat anticanc potenti fluphenazin differ human cancer cell found sever research articl cytotox effect fluphenazin lung breast colon liver brain leukemia oral ovarian skin cancer summar main find review taken togeth find suggest fluphenazin may regul cell cycl reduc cell prolifer caus apoptosi sever type cancer cell besid establish calmodulin inhibitor also found drug abl target cancer relat protein abcb p glycoprotein well regul akt wnt signal pathway studi also refer drug caus dna alter interfer cell invas migrat abil well ros generat collect result impli fluphenazin may favor compound research oncolog therapi
|
D014150;D009369
|
T121;T039;T191
|
36,291,567
|
identif thyrotropin releas hormon trh novel biomark prognosi acut myeloid leukemia acut myeloid leukemia aml biolog genet heterogen hematolog malign unsatisfactori risk stratif system recent novel singl cell rna sequenc technolog reveal heterogen leukemia myeloblast runx runxt aml thyrotropin releas hormon trh biomark cdcdbri myeloblast found prognost runx runxt aml howev clinic genet featur trh aml patient poor understood data tcga aml trh found downregul patient older year old dnmta npm mutat overexpress patient kit mutat valid three cohort primari aml includ beat aml n gse n gse n furthermor demonstr express trh aml could use improv eln risk stratif system conclus preliminari analysi reveal trh novel biomark aml patient could use evalu surviv aml
|
D050676;D015470
|
T123;T191;T116
|
36,291,566
|
investig role zinc atherosclerosi review zinc indispens micronutri human health might play import role develop atherosclerosi zinc could involv atherogen process interact atherogen cell endotheli cell ec vascular smooth muscl cell vsmcs immun cell addit zinc also exert import posit negat function various atherosclerosi relat risk factor includ lipid metabol glucos metabol blood pressur current evid focus relationship zinc status atherogen risk factor well establish direct interact zinc atherosclerosi fulli understood review aim summar associ zinc atherosclerosi explor current find zinc zinc homeostasi associ protein act atherogen process
|
D042783;D050197
|
T047;T046;T025
|
36,291,565
|
role autophagi osteoarthrit cartilag osteoarthr oa one common diseas lead physic disabl age main risk factor degener articular cartilag main focus pathogenesi oa autophagi crucial intracellular homeostasi system recycl flaw macromolecul cellular organell sustain metabol cell grow evid reveal autophagi chondroprotect regul apoptosi repair function damag chondrocyt oa relat autophagi depend differ stage model review discuss charact autophagi oa process autophagi pathway modul drug key molecul non code rnas microrna long non code rnas circular rnas depth investig autophagi need find therapeut target diagnost biomark vitro vivo situat make autophagi effect way oa treatment futur aim review introduc concept autophagi make reader realiz impact oa databas search pubm use keyword list find appropri articl resourc
|
D002358;D010003;D035683
|
T123;T047;T024;T114
|
36,291,564
|
function gait assess use manual semi autom deep learn approach follow standard model peripher nerv injuri mice develop standard model stretch crush sciatic nerv injuri mice compar outcom crush novel stretch crush injuri use standard manual gait sensori assay compar semi autom well deep learn gait analysi method
|
D059348;D000077321;D000071576
|
T066;T037
|
36,291,563
|
pulmonari thrombosi promot tumorigenesi via myeloid hypoxia induc factor cancer patient greater risk thrombosi individu without cancer convers thrombosi diagnost predictor cancer mechan thrombosi promot tumor propag incomplet understood previous studi show hypoxia induc factor hif hif stabil myeloid cell murin thrombi also previous show pulmonari thrombosi increas level hif hif murin lung enhanc level tumorigen factor circul promot pulmonari tumorigenesi studi aim investig regul thrombosi induc tumorigenesi myeloid cell specif hif ie hif hif neutrophil macrophag vitro studi show multipl tumorigen factor upregul secretom hypox versus normox neutrophil macrophag promot lung cancer cell prolifer migrat myeloid hif depend manner next use mous model pulmonari microvascular occlus studi impact pulmonari thrombosi myeloid hif lung tumorigenesi experi mice lack either hif hif myeloid cell demonstr loss either factor elimin advantag given pulmonari tumor format thrombot insult myeloid hif depend tumorigen impact pulmonari thrombosi tumor burden may part driven paracrin thymidin phosphorylas tp given tp level increas hypoxia neutrophil macrophag supern plasma tp level posit correl multipl measur tumor progress wild type mice myeloid cell specif hif hif knockout mice data togeth demonstr import thrombot insult model pulmonari tumorigenesi essenti role myeloid hif mediat tumorigen success
|
D051792;D013939
|
T123;T126;T116
|
36,291,562
|
studi natur sar cov use shell disord model reproduc evolut spread attenu basic tenet shell disord model sdm appli covid harder outer shell virus shell lower pid percentag intrins disord membran protein pidm higher flexibl inner shell higher pid nucleocapsid protein n pidn correl contagi virul respect protect virion anti microbi enzym saliva mucus n disord associ rapid replic virus sdm predict support two experiment observ first observ demonstr lesser greater presenc omicron particl lung bronchial tissu respect greater level mucus bronchi observ reveal lower viral load pangolin cov predict similar low pidn omicron abnorm hard rare seen coronavirus aros fecal oral behavior pangolin via exposur buri fece pangolin provid environ coronavirus cov attenu seen omicron phylogenet studi use show covid relat bat cov lao omicron cluster close proxim pangolin cov suggest recurr interspeci transmiss hard may implic long covid immun system difficulti degrad viral proteinsparticl
|
D000086402;D000086382
|
T005;T067;T047
|
36,291,561
|
phlpp inhibitor nsc neuroprotect rodent model cardiac arrest traumat brain injuri pleckstrin homolog domain leucin rich repeat protein phosphatas phlpp knockout mice improv outcom stroke traumat brain injuri tbi decreas maladapt vascular remodel follow vascular injuri thus small molecul phlpp inhibitor potenti improv neurolog outcom varieti condit pauciti data efficaci known experiment phlpp inhibitor may suit target acut brain injuri assess sever phlpp inhibitor previous explor neuroprotect nsc nsc nsc favor predict chemistri target central nervous system cns neuron cultur studi staurosporin apoptosi glutam excitotox hydrogen peroxid necrosisoxid stress reveal nsc micromolar concentr neuroprotect subsequ test rat model asphyxi cardiac arrest mous model sever tbi show serial dose mgkg nsc day improv hippocamp surviv model taken togeth nsc neuroprotect across multipl insult mechan futur pharmacokinet pharmacodynam pkpd studi warrant optim dose mechanist studi need determin percentag neuroprotect mediat phlpp inhibit potenti modul phlpp independ target
|
D006323;D000070642
|
T047;T046;T037
|
36,291,560
|
acut short term inhal carbon nanofib spragu dawley rat inhal toxic carbon nanofib cnfs clear known due relat relat studi report acut inhal studi short term inhal studi day therefor conduct use spragu dawley rat acut inhal studi rat group expos fresh air control low moder high mgm cnf concentr h thereaft sacrif day short term inhal studi rat group expos fresh air control low moder high mgm cnf concentr hday day sacrif day post exposur mortal observ acut inhal studi thus cnf lc higher mgm signific bodi organ weight chang note day short term inhal studi post exposur period signific effect toxicolog import observ hematolog blood biochem coagul test addit bronchoalveolar lavag bal fluid cell differenti count bal inflammatori marker show cnf exposur relev chang histopatholog examin also found cnf exposur relev histopatholog lesion thus neither acut day inhal exposur cnfs induc notic toxicolog respons
|
D057139
|
T073
|
36,291,559
|
teenag onset colorect cancer digen cancer predisposit syndrom provid clue interact mismatch repair polymeras proofread defici tumorigenesi colorect cancer crc adolesc young adult aya rare known predisposit syndrom includ lynch syndrom ls due high penetr mlh msh allel famili adenomat polyposi fap constitut mismatch repair defici cmmrd polymeras proofread associ polyposi ppap yet aya crc case remain unexplain two teenag sibl multipl adenoma crc identifi matern inherit heterozyg pms exon delet nm c del patern inherit pold variant np paspasn comprehens molecular tumor analysi reveal ultra mutat amp gt mutmb larg contribut cosmic signatur sbs sibl crcs confirm predisposit aya crc result high propens somat mmr defici mmrd compound constitut pol proofread defect cosmic signatur sbs well sbs index patient crc associ earli mutat burst suggest mmrd earli event tumorigenesi somat second hit pms loss heterozygos loh tumor suggest ppd independ acquisit mmrd taken togeth patient repres first case cancer predisposit due heterozyg variant pms pold analysi crcs support pold mutat tumor acquir hypermut concurr mmrd
|
D003123;D015179
|
T047;T191
|
36,291,558
|
biomolecular mechan cardioren protect sodium glucos co transport inhibitor diabet mellitus dm metabol disord character chronic hyperglycemia associ increas risk morbid mortal primarili cardiovascular renal diseas sodium glucos cotransport inhibitor sglt novel drug treatment type dm heart failur hf sglt mediat protect effect renal cardiovascular system review address current knowledg biomolecular mechan cardioren protect effect sglt appear act main non glucos mediat pathway cardioren protect mechan lead reduc chronic renal diseas progress improv myocardi coronari endotheli function concomit possibl observ reflect chang biomark link diabet kidney diseas hf
|
D000077203;D003924;D003928;D006333;D002318
|
T121;T047;T046;T109
|
36,291,557
|
tumor treat field ttfield revers permeabil blood brain barrier vitro vivo despit avail numer therapeut substanc could potenti target cns disord inabl agent cross restrict blood brain barrier bbb limit clinic util novel strategi overcom bbb therefor need improv drug deliveri report first time tumor treat field ttfield approv glioblastoma gbm affect bbb integr permeabl treat murin microvascular cerebellar endotheli cell cerebend khz ttfield h analyz express barrier protein immunofluoresc stain western blot vivo compound normal unabl cross bbb trace healthi rat brain follow ttfield administr khz effect analyz via mri immunohistochem stain tight junction protein furthermor gbm tumor bear rat treat paclitaxel ptx chemotherapeut normal restrict bbb combin ttfield khz tumor volum reduc ttfield plus ptx relat either treatment alon vitro demonstr ttfield transient disrupt bbb function khz rho kinas mediat tight junction claudin phosphoryl pathway altogeth translat clinic use ttfield could repres novel cns drug deliveri strategi
|
D001812;D005909
|
T023;T191
|
36,291,556
|
common mechan activ catalysi p loop fold nucleosid triphosphatas unit divers clarifi obscur hydrolysi mechan ubiquit p loop fold nucleosid triphosphatas walker ntpase analys structur catalyt site bound mg ntp complex analogu result present two articl second elucid whether walker walker b sequenc motif common p loop ntpase could direct involv catalysi found hydrogen bond h bond strict conserv mg coordin serthr walker motif serthr wa aspart walker b motif aspwb particular short even short ngstrms structur bound transit state ts analogu given short h bond impli pariti pka valu h bond partner suggest respons interact p loop ntpase cognat activ partner proton reloc serthr wa aspwb result anion serthr wa alkoxid withdraw proton catalyt water molecul nascent hydroxyl attack gamma phosphat ntp gamma phosphat break away trap proton aspwb pass grotthuss relay via serthr wa beta phosphat compens develop negat charg thought respons activ barrier hydrolysi
|
D043583;D000074182
|
T087;T126;T116
|
36,291,555
|
human alpha antitrypsin suppress nf b activ extend lifespan adult drosophila human alpha antitrypsin haat multifunct protein shown anti inflammatori cellular protect properti previous studi demonstr antiag potenti haat mechan under antiag effect remain elus studi perform detail analysi transcriptom data indic nf b target gene nf b regul pathway select inhibit haat treatment show first detect impact haat treatment inhibit nuclear activ nf b subsequ haat treatment suppress mrna level nf b target gene well nf b p p human senesc cell use drosophila model examin impact haat locomotor activ endur final use adult specif promotor demonstr overexpress haat late stage life signific extend lifespan transgen fli result extend current understand anti inflammatori function haat
|
D000515;D008136
|
T123;T121;T116;T102;T079
|
36,291,554
|
common pattern hydrolysi initi p loop fold nucleosid triphosphatas p loop fold nucleosid triphosph ntp hydrolas also known walker ntpase function atpas gtpase atp synthas often medic import repres one largest evolutionarili oldest famili enzym still consensus catalyt mechan clarifi perform first compar structur analysi structur p loop ntpase contain bound substrat mg ntps analogu proceed assumpt structur featur common p loop ntpase may essenti catalysi result present two articl first consid structur element stimul hydrolysi upon interact p loop ntpase cognat activ partner rnadnaprotein domain specif stimulatori moieti usual arg lys residu insert catalyt site initi cleavag gamma phosphat analyz plethora structur found share featur mechanist interact stimul oxygen atom gamma phosphat group capabl caus rotat one oxygen atom gamma phosphat coordin cofactor mg ion rotat must pull oxygen atom away mg ion rearrang affect properti mg ligand may initi hydrolysi accord mechan elabor second articl
|
D043583;D000074182
|
T087;T126;T116
|
36,291,553
|
small peptid larg protein alzheimersdiseas alzheim diseas ad common neurodegen disord elder two cardin neuropatholog hallmark ad senil plaqu extracellular deposit main constitut beta amyloid neurofibrillari tangl form abnorm phosphoryl tau p tau locat cytoplasm neuron although research made relev progress manag diseas treatment still lack symptomat medic exist diseas meantim laboratori worldwid investig diseas modifi treatment ad present review result center use peptid differ size involv ad present
|
D000544
|
T047;T048
|
36,291,552
|
gpcrs intracellular compart new target drug discoveri architectur eukaryot cell defin extens membran delimit compart entail separ metabol process would otherwis interfer lead function differ cell g protein coupl receptor gpcrs largest class cell surfac receptor signal transduct tradit view chain event initi plasma membran furthermor intracellular traffick intern recycl consid regul receptor desensit cell surfac express contrari accumul data strong suggest gpcrs also signal intracellular compart gpcrs local membran endosom nucleus golgi endoplasm reticulum apparatus mitochondria cell divis compart import site shown orchestr multipl signal regul differ cell pathway review summar current knowledg fascin phenomenon explain gpcrs reach intracellular site stimul endogen ligand potenti physiologicalpathophysiolog role final illustr sever mechan involv modul compartment gpcr signal drug endogen ligand understand gpcr signal compartment regul provid uniqu opportun develop novel pharmaceut approach target gpcrs potenti lead way toward new therapeut approach
|
D043562;D055808
|
T062;T116;T192
|
36,291,551
|
potassium channel therapeut target pulmonari arteri hypertens pulmonari arteri hypertens pah devast diseas high morbid mortal deleteri remodel pulmonari arteri system lead irrevers arteri constrict elev pulmonari arteri pressur right heart failur eventu death difficulti treat pah stem part complex natur diseas pathogenesi sever signal compound known involv eg endothelin prostacyclin inde target pah therapi last decad potassium channelopathi establish novel caus pah specif loss function mutat kcnk gene encod two pore domain potassium channel kcnk task loss function mutat abcc gene encod key subunit sur atp sensit potassium channel katp establish first two potassium channelopathi human cohort pulmonari arteri hypertens moreov voltag gate potassium channel kv repres third famili potassium channel genet chang observ associ pah ion channel gene sinc report associ pah review focus kcnk katp kv potassium channel promis therapeut target pah recent experiment pharmacolog discoveri signific advanc field
|
D024683;D000081029;D053447;D006976;D024642
|
T123;T047;T046;T116
|
36,291,550
|
ractopamin center decad long scientif legal disput lesson benefit safeti issu conflict ractopamin rac synthet phenethanolamin adrenerg agonist use feed addit develop lean increas feed convers effici differ farm anim rac author feed addit pig cattl limit number countri great major jurisdict includ european union eu china russia taiwan ban use safeti ground rac long scientif polit discuss controversi antibiot feed addit present signific inform rac regard applic detect method conflict legal divis play major role controversi deadlock issu warrant attent scientist agriculturist environmentalist health advoc review highlight potenti toxic rac aquat anim emphas scientif evid report potenti harm effect rac aquat environ human health
|
D000821;D034462
|
T168;T054
|
36,291,549
|
programm dna exclus guid argonaut dnase higher cleavag specif achiev hydroxyl guid argonaut protein exist wide eukaryot prokaryot great potenti molecular clone nucleic acid detect dna assembl gene edit howev overal properti satisfactori hinder broad applic herein investig prokaryot argonaut nucleas mesophil bacterium clostridium disporicum cdago explor overal properti especi hydroxyl oh guid found cdago exclus use singl strand dna ssdna guid cleav ssdna plasmid target found length effici guid narrow oh guid nt phosphoryl guid p nt furthermor discov oh guid general offer stronger mismatch discrimin p one oh guid offer narrow length rang higher mismatch discrimin accur cleavag p guid therefor oh guid direct cdago great potenti biolog biomed applic
|
D060565;D003851
|
T123;T121;T126;T116
|
36,291,548
|
implic nanoparticl combat chronic liver kidney diseas progress perspect liver kidney diseas frequent encount problem around globe damag liver kidney may occur result exposur various drug chemic toxin pathogen lead sever diseas condit cirrhosi fibrosi hepat acut kidney injuri liver renal failur regard use nanoparticl nps silver nanoparticl agnp gold nanoparticl aunp zinc oxid nanoparticl znonp emerg rapid develop field studi term safe deliveri various medic target organ minim side effect due physic characterist nps inher pharmacolog effect accident buildup signific impact structur function liver kidney suppress express proinflammatori cytokin ino cox nps known possess anti inflammatori effect addit nps demonstr abil oper antioxid squelch generat ros caus substanc caus oxid stress final pro oxid properti also known increas level ros caus malign liver kidney cell undergo apoptosi result nps regard doubl edg sword whose inher therapeut benefit refin work comprehend term toxic
|
D053768;D015034;D053758;D007674
|
T121;T197;T073;T047
|
36,291,547
|
liraglutid attenu glucolipotox induc rsc schwann cell inflamm dysfunct diabet neuropathi dn type sensori nerv damag occur patient diabet although understand pathophysiolog incomplet dn often associ structur function alter affect neuron among possibl caus nerv damag schwann cell scs thought play key role repair peripher nerv injuri suggest function deficit occur scs may potenti exhibit pathogen role dn therefor elucid mechan underli patholog use develop novel therapeut target regard glucagon like peptid receptor agonist glp ras recent attract great attent amelior scs dysfunct howev detail mechan remain uncertain present studi investig glp ra liraglutid protect rsc scs dysfunct diabet condit mimick high glucos high free fatti acid ffa result show high glucos high ffas reduc viabil rsc scs wherea liraglutid reduc oxid stress upregul antioxid enzym thus protect cell apoptosi liraglutid also inhibit nfb mediat inflamm induc scs switch pro inflammatori cytokin product anti inflammatori cytokin product moreov liraglutid upregul product neurotroph factor myelin relat protein protect effect appear synergist link insulin signal taken togeth find demonstr liraglutid amelior diabet relat sc dysfunct mention mechan suggest modul glp signal scs may promis strategi dn
|
D000069450;D003929
|
T121;T116;T109;T125;T047
|
36,291,546
|
curcumin target non code rnas colorect cancer therapeut biomark implic colorect cancer one common gastrointestin malign high incid rate low rate earli diagnosi complex pathogenesi recent year progress made diagnosi treatment method tumor malign prolifer metastasi treatment still serious affect surviv prognosi patient therefor extrem urgent task current medicin find new anti tumor drug high effici safeti low toxic curcumin shown potent anti tumor anti inflammatori effect consid hot spot research develop anti tumor drug due advantag precis efficaci lower toxic side effect less drug resist recent studi reveal curcumin anti tumor effect exert epigenet regul tumor promotingtumor suppress gene express alter express level non code rnas eg lncrnas mirna circrna herein summar interact curcumin non code rnas occurr develop colorect cancer inform compli review serv scientif reliabl basi viewpoint clinic applic non code rnas colorect cancer
|
D062085;D003474;D035683;D000970;D015179
|
T123;T121;T109;T191;T114;T130
|
36,291,545
|
emerg role non code rnas aortic dissect aortic dissect ad fatal cardiovascular acut diseas high incid mortal serious threaten patient live health pathogenesi ad main includ vascular inflamm extracellular matrix degrad phenotyp convers well apoptosi vascular smooth muscl cell vsmcs howev detail mechan still fulli elucid non code rnas ncrnas includ microrna mirna long non code rnas lncrnas circular rnas circrna emerg class rna molecul without protein code abil play crucial role progress mani diseas includ ad grow number studi shown dysregul ncrnas contribut occurr develop ad modul express specif target gene activ relat protein addit ncrnas exhibit great potenti promis biomark therapeut target ad treatment review systemat summar recent find under mechan ncrna involv ad regul highlight clinic applic biomark therapeut target ad treatment inform review great benefit develop ncrna base therapeut strategi ad patient
|
D062085;D035683;D000784
|
T123;T047;T046;T114
|
36,291,544
|
obtain reliabl diagnost biomark diabet mellitus standard salivari glucos measur salivari glucos frequent util diabet mellitus dm might propos potenti biomark candid dm non invas cost effect achiev adequ diagnost perform dm patient howev salivari glucos level may chang specif condit consequ essenti maintain consist strategi measur saliva take account possibl extern factor influenc salivari glucos level studi analyz salivari glucos level differ handl condit donor depend factor includ age interdiurn variat collect process method structur questionnair use determin symptom predispos factor dm glucos oxidas peroxidas method use estim glucos level blood saliva peopl fast state aim studi investig effect condit salivari glucos level found extran variabl taken account futur salivari glucos use predict biomark dm
|
D001786;D003924
|
T047;T109
|
36,291,543
|
stabil anti angiogen properti titanium dioxid nanoparticl tionp use caco cell titanium dioxid nanoparticl tionp found wide rang product sunscreen paint toothpast cosmet due white pigment high refract index wide rang applic could result direct indirect exposur nps human environ accord conflict level toxic associ nps therefor risk associ report tionp produc use vari methodolog measur studi aim investig effect various media tionp properti hydrodynam size zeta potenti effect tionp exposur human colorect adenocarcinoma caco epitheli cell viabil inflammatori cell stress biomark angiogenesi proteom profil nps increas size time various media zeta potenti stabl tionp also induc cell stress biomark could attribut nps cytotox consequ tionp exposur effect level inflammatori biomark produc caco tionp express anti angiogen properti expos observ advers effect level requir depth investig
|
D053758;D000230;D015179
|
T191;T073
|
36,291,542
|
fingerprint benign cancer skin lesion use vibrat optic coher tomographi differenti among cancer lesion type base presenc new cell blood vessel fibrosi studi use vibrat optic coher tomographi voct examin morpholog stiff benign cancer lesion lesion imag plot weight displac versus frequenc depth use compar cellular dermal collagen new blood vessel fibrot composit normal skin actin keratos ak nodular superfici basal cell carcinoma bccs squamous cell carcinoma sccs melanoma result studi suggest benign cancer lesion differ base addit new cell increas reson frequenc stiff hz mpa new blood vessel peak hz mpa appear less stiff normal blood vessel new fibrous tissu peak hz mpa present carcinoma normal skin partial present hz hz ak result obtain creat imag base locat hz hz hz peak cancer skin lesion suggest fibrous tissu appear surround new cell new lesion blood vessel result studi suggest morpholog locat fibrous tissu relat new cancer associ cell lesion blood vessel may provid inform invas metastat potenti skin cancer invas metastat potenti melanoma may result cancer associ cell lay fibrous tissu use pathway migrat new cancer associ blood vessel vicin new cancer associ cell may promot migrat eventu metastasi ratio peak height hz hz normal cell new lesion cell new lesion blood vessel fibrot tissu may use fingerprint detect melanoma differenti skin cancer non invas use voct
|
D012878;D055623;D008545
|
T191
|
36,291,541
|
associ matern diet pregnanc metabolit profil cord blood cord blood metabolit predict long term diseas risk level differ metabolit might vari respect matern diet well understood aim studi evalu associ differ dietari pattern pregnanc cord blood metabolit includ glycerophospholipid fatti acid polar lipid non esterifi fatti acid amino acid sum hexos particip german lisa birth cohort studi avail data target cord blood metabolom matern diet includ n matern diet last week pregnanc assess non quantit food frequenc questionnair use factor analysi ten dietari pattern identifi use linear regress model explor associ cord blood metabolit correct multipl hypothesi test adjust basic covari fish shellfish associ higher glycerophospholipid fatti acid c n lower c n wherea meat potato pattern direct associ propionylcarnitin c observ associ highlight potenti metabol pathway involv earli program health diseas matern diet well potenti establish quantit biomark dietari pattern pregnant women
|
D005312;D004032
|
T168;T031
|
36,291,540
|
shorten hing design fab x sdab fc bispecif antibodi enhanc redirect cell kill tumor cell cell engag tce antibodi emerg promis cancer therapeut link cytotox cell tumor cell simultan bind cde cell tumor associ antigen taa express tumor cell previous report novel bispecif format igg like fab x sdab fc also known half igvh h ch ch combin convent antigen bind fragment fab singl domain antibodi sdab evalu fab x sdab fc format cell redirect bispecif antibodi tbsab target megfr tumor cell mcde cell focus attent specif hing design sdab arm bispecif antibodi data show tbsab shorter hing amino acid tbsabshort show signific better cell redirect tumor cell elimin tbsab longer classic antibodi hing amino acid tbsablong moreov tbsabshort form mediat better cell tumor cell aggreg increas cd cd express level cell tbsablong form taken togeth result indic alreadi minor chang hing design tbsab signific impact anti tumor activ tbsab may provid new mean improv potenc
|
D018033;D061905;D009369
|
T129;T121;T191;T116
|
36,291,539
|
fibrillin regul arteriol integr retina fibrillin extracellular matrix protein assembl microfibril provid critic function larg blood vessel tissu mutat fibrillin gene associ cardiovascular ocular skelet abnorm marfan syndrom fibrillin compon wall larg arteri poor describ vessel examin microvasculatur retina use wild type mice two model marfan syndrom fbncg fbnmgrmgr mous retina fibrillin detect around arteriol close contact basement membran coloc magp mutat fibrillin fibrillin underexpress characterist alter microvasculatur fbncg fbnmgrmgr mice arteriol enlarg reduc magp deposit focal loss smooth muscl cell coverag losartan prevent aortic enlarg fbncg mice prevent smooth muscl cell loss vessel leaki administr prevent mode moreov losartan also partial rescu defect curat mode thus fibrillin magp perform essenti function arteriolar integr mutant fibrillin induc defect prevent partial rescu pharmacolog new find could implic peopl marfan syndrom
|
D008382
|
T047
|
36,291,538
|
radic mediat rapid vitro format c type cytochrom cytochrom c mutant thermus thermophilus hb rc ca report polypeptid replac cys alanin overexpress cytosol e coli apo form ca mutant apo ca without origin prosthet group obtain simpl chemic treatment retain compact conform amen reconstitut heme b zinc ii protoporphyrin ix gradual follow spontan format coval bond polypeptid porphyrin ring reconstitut apo ca analysi suggest residu cys vinyl group porphyrin ring link thiol ene reaction promot light ambient condit studi describ kinet improv coval bond format accord mechan photoinduc thiol ene reaction involv thiyl radic reaction intermedi ad radic generat reconstitut ca mutant either heme b zinc ii porphyrin acceler bond form reaction support involv radic speci reaction partial observ reconstitut ca dimer form detect sulfuryl radic epr spectroscopi indic thiyl radic cys uniqu cysteinyl residu rc ca coval bond form mediat radic generat also adapt reconstitut apo ca manganes ii protoporphyrin ix also exhibit light mediat coval linkag format therefor radic generat extend versatil produc c type like cytochrom start metallo protoporphyrin ix apo ca instantan
|
D011524;D004926
|
T123;T007;T109
|
36,291,537
|
anti phosphatidylethanolamin anti phosphatidylserin antibodi associ renal involv atherosclerosi cardiovascular manifest raynaud phenomenon diseas activ polish patient system lupus erythematosus evalu associ anti phosphatidylethanolamin ape anti phosphatidylserin ap antibodi cardiovascular risk organ involv diseas activ system lupus erythematosus sle patient
|
D016736;D008180;D050197;D011928;D015186
|
T047;T046;T015
|
36,291,536
|
ala peptid appropri scaffold remov redox silenc copper ion alzheim relat peptid progress neurodegen alzheim diseas ad widespread dementia due age popul current lack molecul abl prevent stop diseas ad even impact societi futur ad multifactori diseas among factor metal ion regard potenti therapeut target case redox compet cu ion involv product reactiv oxygen speci ros bound alzheim relat peptid process contribut overal oxid stress inflamm observ ad made use peptid ligand stop cu induc ros product show ahh sequenc fulli appropri two parent ah aah ahh peptid keep benefici abil cu induc ros even presenc znii compet ion biolog relev ion detail kinet mechan ahh could exert action cu induc ros also propos
|
D003300;D000544
|
T123;T121;T196;T047;T048
|
36,291,198
|
assess choroid vasculatur innat immun cell eye albino pigment mice visual choroid vasculatur innat immun cell eye pigment mice challeng due presenc retin pigment epithelium rpe layer separ choroid retina establish method visual choroid macrophag mast cell vasculatur eye albino pigment mice use cell type specif stain abl visual choroid arteri venous system arteri circl around optic nerv found mice similar zinn haller arteri circl exist human primat three differ structur pattern choriocapillari observ throughout whole choroid honeycomb like maze like finger like pattern choroid mast cell relat dens around optic nerv mast cell distribut middl peripheri differ among strain macrophag found layer choroid thus util simpl reliabl method describ herein allow evalu transgen preclin mous model ocular diseas affect choroid includ age relat macular degener amd diabet choroidopathi retinopathi prematur studi advanc understand pathophysiolog molecular cellular mechan target therapeut diseas
|
D002829;D008268
|
T023;T024;T047
|
36,291,197
|
lc dad esi msms nmr analysi conif wood special metabolit mani speci pinacea famili recogn rich sourc lignan flavonoid polyphenol great common occurr conif europ well use wood industri make plant materi industri wast materi easili access inexpens promis prognosi discoveri new activ compound well find new applic wood industri wast product studi aim analyz phytochem profil wood extract pinacea famili speci endem introduc polish flora use lc dad esi msms method compar respect metabolit profil branch wood methanol extract phytochem profil lignan stilben flavonoid diterpen procyanidin compound detect consider varieti chemic content among distinct speci norway spruce picea abi l hkarst branch wood abund sourc stilben european larch larix decidua mill most contain flavonoid silver fir abi alba mill rich lignan furthermor lignan isol studi materi find confirm wood industri wast materi conif branch potent sourc differ phytochem plant matrix relat simpl facilit futur isol target compound
|
D044945;D064028;D013267;D017705
|
T121;T002;T109
|
36,291,196
|
induc pluripot stem cell step stone vitro human model hear loss hear loss preval sensorineur impair human yet despit activ research effect therapi cochlear implant reach clinic main reason failur multifactori natur disord heterogen late onset hinder identif etiolog factor anoth problem lack human sampl practic work conduct anim although high valuabl data obtain model risk inter speci differ exist may compromis relev gather data human base model therefor dire need irrupt human induc pluripot stem cell technolog field hear research offer possibl generat array otic cell model human origin may enabl identif guid signal cue inner ear develop mechan lead genet alter patholog model also extrem valuabl conduct ototox analys explor new avenu toward regener inner ear review summaris work alreadi conduct cell contempl futur possibl
|
D057026;D034381;D003638;D007758;D000081015
|
T184;T025;T033;T023;T047;T046
|
36,291,195
|
high dimension cytometri dissect immunolog fingerprint idiopath inflammatori myopathi chronic inflamm skelet muscl common featur idiopath inflammatori myopathi iim given rariti diseas potenti difficulti routin obtain target tissu ie standard skelet muscl understand immun signatur iim spectrum remain incomplet insight immun topographi iim need determin specif treatment target accord clinic immunolog phenotyp thus use high dimension flow cytometri investig immun phenotyp anti synthetas syndrom asi dermatomyos dm inclus bodi myositi ibm patient repres entiti iim spectrum compar healthi control studi cd cd b cell compart blood aim provid contemporari overview immun topographi iim spectrum asi character alter cd composit expand follicular helper cell support b cell mediat autoimmun dm unsupervis cluster identifi expans distinct b cell subtyp high express immunoglobulin g igg cd last termin differenti cytotox cd cell distinguish ibm iim interest termin differenti cd cell high express integrin cd mediat cellular adhes infiltr distinct immun cell topographi iim might provid framework target treatment approach potenti improv therapeut outcom
|
D009220;D018979
|
T047
|
36,291,194
|
mrna base approach treat liver diseas diseas affect liver account approxim million death worldwid year increas preval diseas limit efficaci current treatment expect stimul substanti growth global market therapeut target liver current liver transplant curat option avail mani liver diseas gene therapi repres valuabl approach treatment liver play central role myriad essenti metabol function make attract organ gene therapi hepatocyt compris relev target date viral vector constitut prefer approach target hepatocyt gene therapeut interest altern mrna base therapi offer number compar advantag clinic preclin studi undertaken treat inherit metabol diseas affect liver cirrhosi fibrosi hepatocellular carcinoma hepat b cytomegalovirus use lipid nanoparticl encapsul mrnas encod therapeut antigen protein interest discuss
|
D053758;D006528;D008113
|
T191;T073
|
36,291,193
|
iiig new protein exclus ciliari function analysi potenti role cancer patholog identif new protein regul function one main cellular phosphatas protein phosphatas pp essenti find possibl pharmacolog target alter phosphatas function various cellular process includ initi develop multipl diseas iiig regulatori subunit pp initi identifi high polar ciliat cell addit ciliari locat ependym cell recent show iiig extraciliari function regul integr adheren junction review perform detail analysi express local function iiig adult develop normal brain addit provid model iiig protein structur first time verifi classic structur conform characterist pp regulatori subunit maintain review especi focus find evid link iiig dysfunct cours patholog ciliopathi drug depend diseas base neurolog develop develop specif high malign frequenc brain tumor pediatr popul final propos iiig relev regul pp function physiolog patholog process cns
|
D009369;D054645
|
T191;T126;T116
|
36,291,192
|
role cerevisia subpc transcript elong depend c termin region independ ssdna bind domain saccharomyc cerevisia sub scsub defin transcript stimulatori protein due homolog ssdna bind domain ssdbd human pc hpc recent pcsub orthologu elucid eukaryot prokaryot bacteriophag function relat dna metabol addit scsub contain uniqu carboxyl termin region ct unknown function date specif shown sub requir transcript activ well process throughout transcript cycl despit progress made understand mechan under sub function question remain unansw case point whether sub role initi elong differenti predic distinct region protein sub function regul uncov residu key dna scsub interact vivo local ssdbd requir sub recruit promot furthermor use array genet molecular techniqu demonstr ct region requir transcript elong rna polymeras ii rnapii altogeth data indic sub play dual role transcript initi ssdbd elong ct region
|
D012441;D029701
|
T004;T116
|
36,291,191
|
critic review physiolog molecular featur bovin mammari gland develop recent advanc mammari gland uniqu organ abil undergo repeat cyclic chang throughout life mammal among domest livestock speci rumin cattl buffalo constitut distinct class livestock speci known milk produc cattl buffalo contribut total milk suppli world respect also play essenti role develop economi farm communiti provid milk meat draft power develop rumin mammari gland high dynam multiphas natur six development stage embryon prepubert pubert pregnanc lactat involut substanti advanc understand develop mammari gland mous human model thorough investig molecular process underli various stage cow udder develop current review shed light morpholog molecular chang occur various development phase divers speci particular focus cow udder aim explain physiolog differ cattl non rumin mammalian speci human mice monkey understand development biolog mammari gland molecular detail well speci specif variat facilit research work area studi cellular prolifer differenti apoptosi organogenesi carcinogenesi addit depth knowledg mammari gland promot use model organ research work promot enhanc milk yield livestock anim without affect health welfar
|
D002020;D042361
|
T023;T015;T024
|
36,291,190
|
synovi macrophag express oxl requir follicular helper cell differenti joint microenviron signal via oxoxl axi play key role cd cell develop oxl express primarili restrict antigen present cell apc studi design assess role apc mediat oxl express context develop rheumatoid arthriti ra associ cd cell subset analys clinic sampl harvest patient osteoarthr ra addit analys perform use ox mice mice harbor monocytemacrophag specif delet oxl togeth analys reveal tissu specif role oxoxl signal ra specif higher level synovi macrophag oxl express associ enhanc develop follicular helper cell joint microenviron therebi contribut pathogenesi ra tfh differenti found oxoxl depend synovi set overal result indic express oxl synovia macrophag necessari support tfh differenti joint tissu thus offer new insight regard etiolog basi ra progress
|
D000084522;D001172
|
T047;T025
|
36,291,189
|
paracrin senesc mesenchym stromal cell involv inflammatori cytokin nf b pathway known senesc associ secretori phenotyp sasp trigger senesc surround normal cell howev sasp signal regard mesenchym stromal cell age remain fulli elucid therefor present studi aim clarifi molecular mechan late passag msc induc paracrin sasp mediat senesc earli passag mscs ex vivo expans conduct extens character senesc featur bone marrow bm deriv mscs healthi human donor late mscs display enlarg senesc like morpholog induc sasp relat proinflammatori cytokin il il reduc clonogen capac osteogen differenti compar earli mscs note paracrin effect sasp relat il il late mscs induc cellular senesc earli mscs via nf b depend manner moreov cellular senesc earli mscs promot synergist action il il howev inhibit nf b shrna transfect use inhibitor earli mscs block earli mscs cellular senesc caus paracrin sasp late mscs conclus find reveal late mscs display featur senesc ex vivo expans sasp relat proinflammatori cytokin contribut activ cellular senesc program earli mscs may ultim impair function
|
D016328;D059630
|
T129;T116;T025
|
36,291,188
|
nrf regul viabil prolifer resist oxid stress differenti murin myoblast muscl satellit cell increas oxid stress slow regener skelet muscl affect activ muscl satellit cell mscs therefor evalu role nrf transcript factor encod nfel gene main regul antioxid respons muscl cell biolog use immort murin myoblast cell line cc stabl overexpress nrf ii primari mscs isol wild type nfel transcript defici mice nfel tko nrf promot myoblast prolifer viabil oxid stress condit decreas product reactiv oxygen speci furthermor nrf overexpress inhibit cc cell differenti regul express myogen regulatori factor mrfs muscl specif microrna also show nrf indispens viabil mscs sinc lack transcript activ caus high mortal cell cultur vitro normox condit concomit nfel tko mscs grown differenti hypox condit viabl much differenti compar cell isol wild type mice taken togeth nrf signific influenc properti myoblast muscl satellit cell effect might modul muscl microenviron
|
D032496;D035683
|
T123;T025;T114
|
36,291,187
|
cop regul twiktrek heterodimer channel mediat passiv conduct astrocyt matur astrocyt character k conduct passiv conduct chang constant slope voltag involv k homeostasi brain recent report tandem pore domain weak inward rectifi k channel twik kcnk twik relat k channel trek kcnk form heterodimer channel mediat passiv conduct astrocyt howev littl known bind protein regul function twiktrek heterodimer channel found coat protein cop regul surfac express activ twiktrek heterodimer channel astrocyt cop bind direct trek twik heterolog express system howev cop also interact twiktrek heterodimer channel trek depend manner enhanc surfac express heterodimer channel astrocyt consequ regul twiktrek heterodimer channel mediat passiv conduct astrocyt mous brain taken togeth result suggest cop potenti regul astrocyt passiv conduct brain
|
D001253;D024683
|
T123;T116;T025
|
36,291,186
|
spatial tempor divers astrocyt phenotyp spinocerebellar ataxia type mice astrocyt heterogen import featur healthi brain less understood spatiotempor heterogen astrocyt brain diseas spinocerebellar ataxia type sca progress neurodegen diseas caus cag repeat expans gene ataxin atxn character astrocyt across diseas progress four clinic relev brain region cerebellum brainstem hippocampus motor cortex atxnqq mice knock mous model sca found brain region specif chang astrocyt densiti gfap express area earli diseas prior neuron loss express astrocyt core homeostat gene also alter brain region specif manner correl neuron activ indic astrocyt may compens exacerb neuron dysfunct late diseas express astrocyt homeostat gene reduc four brain region indic loss astrocyt function observ obvious correl spatiotempor chang microglia spatiotempor astrocyt alter indic complex orchestr glial phenotyp diseas result support spatiotempor divers glial phenotyp import featur brain diseas may contribut sca pathogenesi brain region diseas stage specif manner
|
D001253;D020754
|
T047;T025
|
36,291,185
|
therapeut target nf b acut lung injuri doubl edg sword acut lung injuryacut respiratori distress syndrom aliard devast diseas caus varieti condit includ pneumonia sepsi trauma recent covid although understand mechan aliard pathogenesi resolut consider increas recent year mortal rate remain unaccept high primarili due lack effect therapi aliard dysregul inflamm character massiv infiltr polymorphonuclear leukocyt pmns airspac associ damag capillari alveolar barrier lead pulmonari edema hypoxemia major hallmark aliard endotheli cell ec inner line blood vessel import cellular orchestr pmn infiltr lung nuclear factor kappa b nf b play essenti role render endothelium permiss pmn adhes transmigr reach inflammatori site thus target nf b endothelium provid attract approach mitig pmn mediat vascular injuri aliard inflammatori diseas well ec dysfunct major pathogen mechan review discuss role regul nf b context ec inflamm evalu potenti problem target therapi aliard
|
D000086382;D055371;D012128
|
T047;T037;T067
|
36,291,184
|
dysregul cell cell communic character pulmonari fibrosi idiopath pulmonari fibrosi ipf progress diseas older adult character fibrot replac function gas exchang unit lung strongest risk factor ipf genet variantin promot region gel form mucin mucb better understand mucb variant influenc develop fibrosi use nichenet r packag leverag public avail singl cell rna sequenc data identifi evalu epithelia particip gas exchang influenc ligand express control mucb variant fibrot environ observ loss type alveolar epithelia aeci character singl cell rna transcriptom fibrot lung valid pattern aeci loss use singl nuclear rna sequenc examin aeci transcriptom found enrich transcript signatur il areg previous shown mediat aberr epitheli fluidize ipf murin bleomycin model moreov found proteas adam upstream il tran signal enrich control mucb variant donor use immunofluoresc valid role enhanc express adam among mucb variant suggest involv ipf pathogenesi mainten
|
D015850;D054990
|
T129;T047;T116
|
36,291,183
|
neutrophil extracellular vesicl delic balanc pro inflammatori respons anti inflammatori therapi extracellular vesicl ev releas extracellular environ cell activ apoptosi work signal transduc ev import mediat intercellular communic convoy protein nucleic acid lipid metabolit neutrophil extracellular vesicl nev contain molecul act key modul inflamm immun respons due potenti therapeut tool studi nev increas recent year howev knowledg nev still infanc review summar current understand role nev framework neutrophil inflamm function diseas develop therapeut potenti nev clinic treatment strategi deepli discuss moreov promis research landscap nev near futur also examin
|
D000067128;D009696
|
T026;T123;T114
|
36,291,182
|
recent advanc molecular therapeut corneal scar treatment process corneal wound heal complex induc scar format corneal scar lead caus blind worldwid fibrot heal major ocular wound disrupt high organ fibrillar collagen arrang corneal stroma render opaqu process regain organ extracellular matrix ecm arrang stromal layer restor corneal transpar complic surfac retent capac ocular drug poor larg gap suitabl corneal donor clinic requir therefor effici way treat corneal scar need eight major class intervent target therapeut tool heal scar cornea includ base exosom target gene therapi microrna recombin viral vector histon deacetylas inhibitor bioactiv molecul growth factor nanotechnolog review highlight recent advanc molecular therapeut restor cornea without scar also provid scope overcom limit present studi perform robust clinic research use strategi
|
D065306;D035683
|
T033;T123;T037;T114
|
36,291,181
|
morbid mortal neutropen patient viscer surgeri narrat review leukocyt essenti function immun system cell cell interact human bodi hematolog diseas well chemotherapeut treatment due cancer lead occasion even perman leukocyt defici normal leukocyt neutrophil granulocyt leukopenia therefor most character decreas neutrophil granulocyt consequ neutropenia increas suscept infect also heal disord suggest due disturb cell cell interact surgic treatment leucocyt disord patient suffer neutropenia sometim need surgeri reason less known morbid mortal patient narrat review critic summar result recent research particular field result review suggest neutropen patient need emerg surgeri higher mortal risk compar non neutropen patient contrast elect surgeri clear tendenc higher mortal risk neutropen patient role neutrophil granulocyt inflamm immun surgic patient emphas result evalu studi show methodolog flaw due small sampl size risk bias research evalu risk postop complic particular infecti complic surgic site infect neutropen patient undergo elect surgeri address role neutrophil function postop morbid mortal
|
D009503;D013505
|
T061;T047
|
36,291,180
|
gene enrich analysi astrocyt subtyp psychiatr disord psychotrop medic dataset astrocyt mani import function brain role psychiatr disord respons psychotrop medic still elucid use gene enrich analysi assess relationship differ astrocyt subtyp psychiatr diseas psychotrop medic antipsychot antidepress mood stabil also carri qpcr analys look studi assess chronic effect drug astrocyt marker gene express bioinformat analysi identifi gene enrich differ astrocyt subtyp psychiatr disord highest level enrich found schizophrenia support role astrocyt disord also found differenti enrich astrocyt subtyp associ specif biolog process highlight complex respons astrocyt patholog condit enrich protein phosphoryl astrocyt diseas confirm biochem analysi analysi linc chemic perturbagen gene signatur also found kinas inhibitor high discord astrocyt scz associ gene signatur howev found common gene enrich differ psychotrop medic astrocyt subtyp limit result confirm look studi qpcr analysi also report littl effect psychotrop medic common astrocyt marker gene express suggest astrocyt primari target medic convers antipsychot medic affect astrocyt gene marker express postmortem schizophrenia brain tissu support specif astrocyt respons differ patholog condit overal studi provid uniqu view astrocyt subtyp effect medic astrocyt diseas contribut understand role psychiatr disord offer insight target astrocyt therapeut
|
D014150;D001523
|
T121;T039;T048
|
36,291,179
|
low nephron number induc matern protein restrict prevent nicotinamid ribosid supplement depend sirtuin activ reduc nephron number birth due critic gestat condit includ matern malnutrit associ risk develop hypertens chronic kidney diseas adulthood intervent current avail augment nephron number recent shown sirtuin sirt import role dictat proper nephron endow present studi explor whether sirt stimul mean supplement nicotinamid ribosid nr precursor sirt co substrat nicotinamid adenin dinucleotid nad abl improv nephron number murin model low protein lp diet find show reduc nephron number newborn mice day born mother fed lp diet associ impair renal sirt express restor supplement nr glomerular podocyt densiti well rarefact renal capillari also improv nr administr mechanist term restor sirt express nr mediat induct prolifer activ receptor ppar coactiv pgc moreov nr restor sirt activ shown reduct acetyl optic atrophi opa superoxid dismutas sod result improv mitochondri morpholog protect oxid damag mice born mother fed lp diet result provid evid feasibl prevent nephron mass shortag birth sirt boost nephrogenesi thus provid therapeut option possibl limit long term sequela reduc nephron number adulthood
|
D056566
|
T126;T116
|
36,291,178
|
inhibit cell uptak delta omicron sar cov pseudovirus n acetylcystein irrespect oxidoreduct environ bind sar cov spike cell receptor angiotensin convert enzym ace crucial target prevent therapi covid explor involv oxidoreduct mechan investig effect oxid antioxid virus uptak ace express cell human origin ace hek cell uptak pseudovirus carri envelop either delta omicron variant sar cov evalu mean cytofluorimetr approach thiol n acetyl l cystein nac inhibit uptak variant reproduc dose depend fashion ascorb acid show modest effect contrast neither hydrogen peroxid h system generat reactiv oxygen speci ros play import role intracellular alter produc sar cov abl affect abil either delta omicron sar cov pseudovirus intern ace express cell addit neither h ros generat system interf abil nac inhibit mechan moreov base previous studi prevent pharmacolog approach nac would advantag decreas risk develop covid irrespect variant time respiratori viral infect associ comorbid
|
D000085962;D000086382
|
T047;T126;T116;T067
|
36,291,177
|
musashi mir precursor interact mediat synergist oncogen induc co infect two avian retrovirus synerg avian leukosi virus subgroup j alv j reticuloendotheliosi virus rev report frequent co infect chicken flock although signific progress made understand tumorigenesi mechan alv rev two simpl oncogen retrovirus induc synergist oncogen remain unclear studi found alv j rev synergist promot mutual replic suppress cellular senesc activ epitheli mesenchym transit emt vitro mechanist structur protein alv j rev synergist activ express musashi msi direct target pri mir rna bind site inhibit matur mir reliev inhibit nf bkiaaegfr signal therebi suppress cellular senesc activ emt reveal synergist oncogen mechan induc alv j rev vitro elucid synergist oncogen two simpl retrovirus could help understand mechan tumorigenesi alv j rev co infect help identifi promis molecular target key obstacl joint control alv j rev develop clinic technolog
|
D060085;D011201;D001354;D035683
|
T123;T047;T005;T114
|
36,291,176
|
genom amplif ubqln prognost treatment resist factor ubiquilin ubqln proteasom shuttl factor direct bind ubiquityl protein deliv cargo proteasom degrad previous show upregul ubqln determin dna damag respons ddr degrad mrea howev regulatori mechan dna level transcript post transcript level control ubqln mrna level remain unknown studi screen solid tumor type valid find immunohistochemistri analysi ubqln upregul mrna protein level signific valu observ liver breast ovarian lung esophag cancer patient high ubqln mrna level signific poor prognos cancer type dna amplif identifi main mechan promot ubqln upregul multipl cancer even earli phase tumor develop use crispr screen dataset ubqln identifi common essenti gene tumor cell viabil solid tumor deriv cell line ovarian cancer cell line high ubqln mrna level platinum base chemotherapi resist sensit poli adenosin diphosph ribos polymeras inhibitor parpi find highlight util ubqln signific pan cancer theranost factor precis oncolog biomark ddr relat drug resist
|
D011815;D010051
|
T123;T191;T114
|
36,291,175
|
fama famili sequenc similar member cell densiti regul protein promot prolifer migrat cervic cancer cell fama famili sequenc similar member gene controversi discuss possess pro anti tumorigen potenti analyz regul cellular fama protein level studi function role fama hpv posit cervic cancer cell find fama protein express strong depend cell densiti fama readili detect low cell densiti undetect high cell densiti regul occur post transcript mirror correspond chang rna level show fama protein level high increas cervic cancer cell cultiv hypoxia compar normoxia provid evid fama hypoxia respons gene control subunit hif hypoxia induc factor transcript factor yet strong relat increas fama protein level hypox cell predomin cell densiti depend occur post transcript anti prolif effector besid hypoxia silenc hpv ee oncogen express cervic cancer cell also result increas fama level compar untreat cell function analys reveal fama repress lead pronounc anti prolif well anti migratori effect cervic cancer cell taken togeth result provid insight regul fama protein level reveal underli tight cell densiti depend control moreov identifi fama critic determin phenotyp cervic cancer cell promot prolifer migrat capac
|
D002583;D009856;D030361
|
T123;T047;T191;T116
|
36,291,174
|
pan cancer analysi prognost immunotherapeut valu mitd microtubul interact traffick domain contain mitd associ absciss cytokinesi howev systemat investig role cancer lack therefor explor pan cancer role mitd use multipl databas express clinic surviv immunolog enrich analys perform use r packag onlin tool breast cancer singl cell level analysi immunochemistri vitro experi perform explor mechan mitd nomogram establish predict prognosi patient breast cancer evalu immunotherapi biomark base two dataset cancer high mitd express associ favor prognosi instanc inhibit tumor cell prolifer migrat breast cancer mitd may regul cancer develop alter tumor microenviron mitd express may predict respons immun checkpoint blockad platinum poli adp ribos polymeras inhibitor therapi nomogram use determin prognosi patient breast cancer mitd also predict respons immunotherapi first pan cancer studi mitd shown play differ role cancer develop therapi breast cancer mitd inhibit cell prolifer migrat serv new biomark
|
D000082082;D001943
|
T129;T121;T191;T043
|
36,291,173
|
novel self form nanos dds particl bnct util hydrophob boron cluster molecular glue effect bnct non invas cancer therapi allow cancer cell death without harm adjac cell howev applic limit owe challeng work clinic approv boron b compound drug deliveri system dds address issu develop self form nanoparticl consist biodegrad polym name ab type lactosom ab lac load b compound three carboran isom p carboran three relat alkyl deriv ie dimethi carboran dic carb dihexyl carboran dic carb didodecyl carboran dic carb separ load dic carb high load ab lac particl stabil indic molecular glue effect effici vitro b uptak dic carb bnct confirm non cytotox concentr sever cancer cell line vivoex vivo biodistribut studi indic ab lac particl remark accumul within h post inject tumor lesion mice bear syngen breast cancer cell maximum accumul reach h ex vivo b biodistribut ratio tumornorm tissu tn tumorblood tbl dic carb load particl remain stabli high h therefor propos dic carb load ab lac particl promis candid medicin bnct
|
D001895;D016754
|
T061;T196
|
36,291,172
|
monitor nlrp inflammasom activ exhaust clinic sampl refin flow cytometri protocol asc speck format measur direct whole blood ex vivo stimul alter nlrp inflammasom pathway includ hyper activ exhaust implic pathophysiolog mani diseas follow cell stimul aggreg asc protein multiprotein complex asc speck propos specif read monitor nlrp inflammasom activ flow cytometri clinic sampl far paper describ techniqu detect asc speck format direct whole blood without cell purif none includ ex vivo stimul object studi thus develop simpl shorten flow cytometri protocol detect asc speck format direct whole blood includ ex vivo stimul step show red blood cell lysi remov lps stimul step asc speck format detect monocyt neutrophil healthi donor direct nigericin stimul whole blood sampl use sampl four septic shock patient show techniqu allow detect nlrp inflammasom exhaust clinic sampl novel shorten simpl whole blood protocol facilit day day monitor nlrp inflammasom activ exhaust monocyt neutrophil clinic studi
|
D058847;D000071199
|
T123;T116
|
36,291,171
|
exosom plasma gelsolin immunosuppress mediat ovarian tumor microenviron determin chemoresist ovarian cancer ovca fatal gynecolog cancer year surviv rate less main due late diagnosi drug resist overexpress plasma gelsolin pgsn key contribut factor ovca chemoresist immunosuppress gelsolin gsn multifunct protein regul activ actin filament cleavag cap nucleat general play import role cytoskelet remodel gsn three isoform cytosol gsn plasma gsn pgsn gelsolin exosom contain pgsn releas contribut progress ovca review describ pgsn overexpress inhibit chemotherapi induc apoptosi trigger posit feedback loop pgsn express also describ mechan exosom pgsn promot apoptosi dysfunct tumor kill immun cell discuss potenti pgsn prognost diagnost therapeut marker also present herein
|
D010051;D000970
|
T121;T191;T109
|
36,291,170
|
transplant human fetal spinal cord deriv npcs prime polyglutam conjug rhorock inhibitor acut spinal cord injuri neural precursor cell npc transplant repres promis therapi treat spinal cord injuri scis howev despit success result obtain preclin model clinic translat approach remain challeng due part lack consensus optim cell sourc human neuron cell depend cell sourc addit limit npc base therapi includ high tumorigen potenti alongsid poor graft surviv engraft host spinal tissu previous demonstr npcs deriv rat fetal spinal cord prime polyglutam pga conjug form rhorock inhibitor fasudil pga ss fas display enhanc neuron differenti graft surviv compar non prime npcs conduct similar studi human fetal spinal cord deriv npcs hfnpcs legal gestat interrupt late gestat stage week vitro expand hfnpcs retain neural featur multipot self renew support develop cell bank strategi transplant establish simpl procedur prime hfnpcs overnight incub pga ss fas fas equiv improv neuron differenti overcam neurit like retract lysophosphatid acid induc rhorock activ transplant prime hfnpcs immun defici mice nu ncr foxn nu immedi eighth thorac segment compress prompt enhanc migrat graft cell dorsal ventral spinal cord increas preserv gabaerg inhibitori lbx express glutamaterg excitatori tlx express somatosensori interneuron elev number preserv c fos express activ neuron surround injuri epicent low percentag overal prime procedur use pga ss fas could repres altern methodolog improv capabl hfnpc line translat approach acut sci treatment
|
D011099;D013119;D017690
|
T061;T116;T037
|
36,291,169
|
prolong suppress neuropath hypersensit upon neurostimul posterior insula mice neurostimul base therapeut approach emerg altern pharmacolog drug need develop optim efficaci reduc variabl despit key relev pain insular cortex explor cortic neurostimul approach develop approach perform repetit transcrani direct current stimul posterior insula pi tdcs studi impact sensori avers compon neuropath pain pain relat anxieti under neural circuitri mice use behavior method pharmacolog intervent express activ induc gene product fos observ repetit pi tdcs strong attenu develop neuropath mechan allodynia also revers chronic establish mechan cold allodynia sever week post treatment employ descend opioiderg antinocicept pathway pain relat anxieti pain relat avers inhibit pi tdcs effect associ long term suppress activ key area involv pain modul cingul prefront motor cortic data uncov signific potenti target insular cortex object pain relief open way detail mechanist analys contribut improv cortic neurostimul therapi use clinic manag pain
|
D065908;D009437;D009044
|
T061;T184;T029;T023;T047
|
36,291,168
|
predict progress autosom domin polycyst kidney diseas chang telomer epigenom autosom domin polycyst kidney diseas adpkd common inherit caus chronic kidney diseas polycystin amp nbsp pkd gene mutat howev intra famili variabl symptom suggest non mendelian contribut diseas goal find marker track epigenet chang common rapid progress form diseas risk adpkd increas age age shorten telomer length tl telomer nucleoprotein structur compos main three complex shelterin cst rna contain telomer repeat terra protect end chromosom degrad fusion play role maintain cellular stabil repair telomer damag terra transcrib telomer region part engag dnarna hybrid r loop chromosom end track tl terra level blood sampl patient healthi control studi demonstr tl shorten terra express level dna attach fraction increas autosom domin polycyst kidney patient mutat pkd pkd compar control group moreov observ express terra engag r loop higher length telomer shorter patient adpkd show rapid diseas progress intrafamili variat tl terra level mutat would indic reliabl epigenet potenti biomark diseas monitor
|
D016891;D062085
|
T019;T047;T123;T114
|
36,291,167
|
ferroptosi shed light mechan therapeut opportun liver diseas cell death vital physiolog patholog phenomenon develop process organ ferroptosi kind newli discov regul cell death rcd differ rcd pattern apoptosi necrosi autophagi morpholog biochem genet level kind iron depend mode death mediat lipid peroxid lipid reactiv oxygen speci aggreg noteworthili number studi focus ferroptosi increas exponenti sinc ferroptosi first found liver organ store iron human bodi recent frequent found differ degre iron metabol disord lipid peroxid ferroptosi characterist various liver diseas numer investig discov progress various liver diseas affect via regul ferroptosi may provid potenti therapeut strategi clinic hepat diseas review aim summar mechan updat research progress ferroptosi provid novel promis direct treatment liver diseas
|
D000079403;D008107
|
T033;T047;T043
|
36,291,166
|
smurf suppress enhanc temozolomid chemosensit glioblastoma facilit pten nuclear transloc tumor suppressor pten main inhibit pikakt pathway cytoplasm maintain dna stabil nucleus status pten remain therapeut effect chemoresist dna alkyl agent temozolomid tmz glioblastoma gb howev under mechan pten interconnect role cytoplasm nucleus tmz resist still unclear studi report tmz induc pten nuclear import depend pten ubiquityl modif smurf smurf suppress decreas tmz induc pten nuclear transloc enhanc dna damag addit smurf degrad cytoplasm pten ke nuclear import defici pten mutant activ pikakt pathway tmz treatment altogeth smurf interconnect promot pten nuclear function dna repair cytoplasm function activ pikakt pathway resist tmz result provid proof concept demonstr potenti strategi overcom tmz resist pten wild type gb patient target smurf
|
D005909
|
T191
|
36,291,165
|
strategi brain maintain forc product pain contract motor unit pool reorgan common symptom neuromuscular diseas pain chang human movement mani way use decompos electromyograph signal investig strategi brain recruit differ pool motor unit mus produc torqu induc muscl pain term fire rate fr recruit threshold rt action potenti amplitud muap amp properti use defin two group gg base k mean cluster method ml intramuscular hyperton isoton salin solut inject induc pain act placebo isometr isokinet knee extens contract isometr torqu decreas pain induct hyperton solut occur isokinet torqu occur mus organ inject solut support increas rt g g mus howev induc pain hyperton solut rt increas exacerb condit fr also decreas muap amp increas g mus therefor studi propos strategi maintain forc product pain recruit mus higher rt muap amp
|
D018482;D009046
|
T023;T025;T024
|
36,291,164
|
iron oxid nanoparticl combin static magnet field bone remodel iron oxid nanoparticl ionp extens use bone relat studi biomateri due uniqu magnet properti good biocompat endocytosi ionp enter cell promot osteogen differenti inhibit osteoclastogenesi static magnet field smfs also found enhanc osteoblast differenti hinder osteoclast differenti ionp expos smf becom rapid magnet ionp smfs work togeth synergist enhanc effect individu effect differenti function osteoblast osteoclast articl review individu combin effect differ type ionp differ intens smfs bone remodel also discuss mechan under synergist effect ionp smfs bone remodel
|
D010012;D060526
|
T070;T042
|
36,291,163
|
modul neutrophil activ solubl complement cleavag product depth analysi cellular fluid phase innat immun respons mani diseas predomin involv activ neutrophil granulocyt complement factor howev compar systemat analysi earli impact key solubl complement cleavag product includ anaphylatoxin neutrophil granulocyt function lack neutrophil activ monitor flow cytometri regard cellular electro physiolog cellular activ chang surfac express activ marker studi reveal major effect induc ca ca neutrophil function contrast exposur ca ca des arg stimul neutrophil activ reflect chang membran potenti intracellular ph glucos uptak cellular size similar ca ca des arg monitor complement cleavag product enhanc phagocytosi reactiv oxygen speci generat ca ca des arg also alter neutrophil surfac express sever complement receptor neutrophil activ marker includ car cdl cd cdb among other addit detail character ca induc effect perform time resolut second multiparametr respons neutrophil analyz princip compon analysi reveal cdb cd cd key surrog ca induc effect overal provid comprehens insight earli interact neutrophil granulocyt activ complement split product result neutrophil activ result provid basi better import time resolv multiparametr understand neutrophil relat patho physiolog
|
D009504;D000706
|
T123;T116;T025;T131
|
36,291,162
|
polyubiquitin sumoyl site regul stabil zo protein seal tight junction tight junction tjs regul transit ion molecul paracellular pathway epitheli cell zonula occluden zo cytoplasm tj protein studi ubiquitin hzo employ mutant sumoyl site k present guk domain putat ubiquitin residu k k locat guk domain prolin rich region respect immunoprecipit experi done mdck cell transfect wild type wt hzo ubiquitin site mutant hzo kr kr observ diminish ubiquitin mutant indic residu k k hzo acceptor ubiquitin moreov use tube found residu k k hzo target k polyubiquitin signal proteasom degrad accord compar wt hzo half life hzo mutant kr kr augment h respect instead ubiquitin hzo mutant kr increas half life diminish h lack lysin residu hzo affect tj seal peak ter decreas monolay mdck cell transfect mutant result highlight import zo ubiquitin sumoyl maintain healthi stabl pool zo molecul tj
|
D019108;D058207
|
T044;T030
|
36,291,161
|
human stem cell deriv brain liver chip assess blood brain barrier permeat pharmaceut drug signific advanc field preclin vitro blood brain barrier bbb model achiev recent year develop monolay base cultur system toward complex multi cellular assay coupl model relev organoid system integr investig blood brain barrier permeat larger pictur drug distribut metabol still miss report first time combin human induc pluripot stem cell hipsc deriv blood brain barrier model cortic brain liver spheroid model donor close microfluid system mps two model compound atenolol propranolol use measur permeat blood brain barrier assess metabol substanc show vivo like permeat behavior metabol vitro therefor novel multi organ system enabl measur parent compound concentr also metabolit distribut blood brain barrier
|
D001812;D057026;D004364
|
T121;T023;T025
|
36,291,160
|
new approach method hazard identif case studi azol fungicid affect molecular target associ advers outcom pathway cholestasi triazol fungicid propiconazol pi tebuconazol te show hepatotox vivo eg hypertrophi vacuol liver cell follow interact nuclear receptor pxr pregnan x receptor car constitut androstan receptor accord azol affect gene express associ advers outcom vivo also human liver cell vitro addit gene indic liver cholestasi affect vivo vitro therefor analyz capabl pi te caus cholestasi advers outcom pathway aop driven approach hepat cell human origin vitro consid also previous vivo studi bile salt export pump bsep activ assay confirm azol weak inhibitor bsep altern express various cholestasi associ target gene protein well mitochondri membran function publish vivo data howev demonstr neither pi te caus cholestasi rodent bioassay discrep explain vivo concentr azol well ec bsep inhibit regulatori perspect illustr toxicogenom human vitro model valuabl tool detect potenti substanc caus specif type toxic come sound regulatori conclus vivo relev find result consid broader context also includ toxicokinet weight evid approach
|
D005659;D000073931;D002779
|
T131;T047;T067
|
36,291,159
|
usp induc chemoresist tripl negat breast cancer via deubiquitin stabil abcb tripl negat breast cancer tnbc account breast cancer tnbc express estrogen receptor progesteron receptor human epiderm growth factor receptor cytotox chemotherapi surgeri current therapeut strategi tnbc patient chemoresist tnbc limit effici strategi shorten lifespan patient explor target therapi ongo tnbc research aim present studi identifi mechan under acquir resist tnbc explor relationship express usp abcb found ubiquitin specif proteas usp potenti therapeut target overcom chemoresist tnbc usp overexpress increas chemoresist tnbc knockdown usp effect increas chemosensit chemoresist tnbc usp inhibitor effect induc apoptosi suppress metastasi chemoresist tnbc clarifi usp specif deubiquitin enzym abcb play essenti role drug resist usp direct interact abcb regul stabil conclud usp promot chemoresist tnbc stabil abcb protein
|
D064726
|
T191
|
36,291,158
|
map univers eph receptor ephrin ligand transcript epitheli fiber cell eye len eye len transpar ellipsoid organ anterior chamber eye requir fine focus light onto retina transmit clear imag cataract defin opac len remain lead caus blind world recent studi human mice indic eph ephrin bidirect signal import maintain len transpar specif mutat polymorph epha receptor ephrin ligand link congenit age relat cataract unclear variant eph ephrin express len whether preferenti express epitheli vs fiber cell perform detail analysi eph receptor ephrin ligand mrna transcript whole mous lens epitheli cell fraction fiber cell fraction use new rna isol method compar control sampl epha knockout ko ephrin ko sampl result reveal presenc transcript eph receptor ephrin ligand various fraction len cell use specif primer set rt pcr sequenc verifi variant gene express found two epitheli cell specif gene surpris also identifi one eph receptor variant express ko len fiber absent control len fiber also identifi one low express ephrin variant express ephrin control sampl result indic len express almost eph ephrin may mani receptor ligand pair play role len homeostasi
|
D036104;D007908;D002386
|
T116;T190;T192;T033;T023;T126;T047
|
36,291,157
|
endophyt mediat stress toler plant sustain strategi enhanc resili assist crop improv biotic abiot stress sever affect agricultur affect crop product soil fertil health stress may signific financi repercuss necessit practic cost effect ecolog friend approach lessen negat impact plant sever agrochem fertil pesticid insecticid use improv plant health protect howev chemic supplement serious implic human health plant sessil move escap avoid stress therefor evolv develop high benefici interact endophyt target use benefici plant endophyt role combat biotic abiot stress gain attent therefor import experiment valid interact determin affect plant fit review highlight research shed light endophyt help plant toler biotic abiot stress plant symbiont plant microbiota interact great need focus research effort vital area achiev system level understand plant microb interact occur natur
|
D060026;D007306
|
T131;T004
|
36,291,156
|
unravel differenti transcriptom cell type zebrafish larva intestin liver zebrafish intestin liver vertebr deriv endoderm great effort devot deciph molecular mechan control specif develop zebrafish intestin liver howev genom wide comparison transcriptom two organ larval stage remain unexplor lack extens identif featur gene mark specif cell type zebrafish intestin liver day post fertil larval fish start food intak report rna sequenc singl cell rna sequenc intestin liver separ dissect wild type zebrafish larva day post fertil togeth experiment valid gene rna whole mount situ hybrid identifi distinct transcriptom larval intestin liver also consider number featur gene mark intestin bulb mid intestin hindgut mark hepatocyt cholangiocyt meanwhil identifi intestin liver enrich transcript factor gene zebrafish larva day post fertil find provid rich molecular cellular resourc studi cell pattern specif earli develop zebrafish intestin liver
|
D015027;D059467
|
T081;T086;T013
|
36,291,155
|
vitro cell death mechan induc dicoma anomala root extract combin znpcs mediat photodynam therapi lung cancer cell global lung cancer remain lead caus morbid mortal men women enhanc photodynam therapeut effect vitro present studi design reduc dose depend photodynam therapi pdt evalu anticanc effect dicoma anomala anomala root extract ie chloroform chl ethyl acet etoac methanol meoh lung cancer cell activ extract anomala da use establish inhibitori concentr ic use evalu anticanc efficaci da combin znpcs mediat pdt ic studi evalu cell death mechan cell viabil cytotox livedead tm assay flow cytometri annexin v fluorescein isothiocyan fitc propidium iodid pi stain immunofluoresc p p bax caspas express fluorometr multiplex assay caspas h post treatment ic concentr znpcs mediat pdt da meoh root extract morpholog chang accompani dose depend increas cytotox decreas viabil prolifer experiment model apoptosi high favor cell death mechan observ combin therapi group apoptot activ support increas number dead cell livedead tm assay upregul p p bax caspas apoptot protein vitro experi confirm cytotox antiprolif effect da root extract monotherapi combin znpcs mediat pdt taken togeth find demonstr da could promis therapeut candid worth explor differ type cancer
|
D010778;D008175
|
T061;T191
|
36,291,154
|
dendrit cell macrophag microenviron human clear cell renal cell carcinoma imprint mosaic myeloid subtyp associ patient surviv sinc initi descript eli metchnikoff phagocyt spark interest varieti biolog disciplin import cell perform central function tissu repair immun activ well toler myeloid cell immunoinhibitori particular tumor microenviron presenc general associ poor patient prognosi cell high adapt plastic modul perform desir function antitumor activ key program molecul identifi human clear cell renal cell carcinoma ccrcc consid immunogen yet checkpoint blockad target cell dysfunct shown limit clinic efficaci suggest addit layer immunoinhibit previous describ enrich renal cell carcinoma erc dcs often found tight contact dysfunct cell use transcript profil flow cytometri describ ercdc repres mosaic cell type within macrophag continuum co express marker polar state reflect tissu specif signal characterist rcc renal tissu homeostasi ercdc tissu resid increas preval relat tumor grade accord high ercdc score predict poor patient surviv within profil therapeut target vsig nrp gpnmb identifi promis improv immunotherapi
|
D002292;D007680;D001688
|
T121;T123;T191
|
36,291,153
|
intracellular metabolom identifi efflux transport inhibitor routin caco cell permeabl assay biolog implic caco screen routin use laboratori measur permeabl compound identifi substrat efflux transport studi hypothes efflux transport inhibit compound predict intracellular metabol signatur caco cell assay use test intestin permeabl use select inhibitor transport knock ko cell target liquid chromatographi tandem mass spectrometri lc ms method identifi metabolit increas cell deplet p glycoprotein pgp activ four metabolit alter breast cancer resist bcrp inhibit nine metabolit identifi multidrug drug resist protein mrp signatur score system creat could discrimin among three transport valid addit inhibitor pgp mrp substrat score inhibitor contrast bcrp substrat inhibitor show similar intracellular metabolom signatur network analysi signatur metabolit led us investig chang enzym one carbon metabol folat methionin cycl data show methylenetetrahydrofol reductas mthfr protein level increas pgp inhibit thymidyl synthas ts protein level reduc pgp mrp inhibit addit methionin cycl also affect pgp mrp inhibit summari demonstr routin caco assay potenti identifi efflux transport inhibitor parallel substrat assay current use mani dmpk laboratori inhibit efflux transport biolog consequ
|
D027425;D013940
|
T123;T126;T116
|
36,291,152
|
come age btk inhibitor therapi review zanubrutinib waldenstrm macroglobulinemia waldenstrm macroglobulinemia wm rare form non hodgkin b cell lymphoma variabl clinic present impact patient qualiti life caus anemia peripher neuropathi serum hyperviscos extramedullari diseas symptom sever safe effect treatment regimen patient wm choic therapi made person fashion consid patient symptom comorbid genom profil bruton tyrosin kinas btk inhibitor new option treat patient wm zanubrutinib next generat coval btk inhibitor design fewer target effect previous btk inhibitor review summar pharmacokinet pharmacodynam properti zanubrutinib well safeti efficaci find explor health econom outcom research associ cost treat patient wm reason zanubrutinib may cost effect treatment option compar ibrutinib first generat btk inhibitor futur direct treatment wm focus use zanubrutinib combin therapi combin base effect ibrutinib acalabrutinib treatment may effect appli zanubrutinib given similar mechan action btk inhibitor combin therapi could also help prevent develop diseas resist minim toxic support treatment regimen finit durat
|
D008258;D016393
|
T191
|
36,291,151
|
apelin promot prostat cancer metastasi downregul timp via increas mir p express prostat cancer common affect urinari tract men metastat prostat cancer low surviv rate apelin belong famili adipokin associ cancer develop metastasi howev effect apelin prostat cancer metastasi undetermin analysi databas reveal posit correl apelin level progress metastasi prostat cancer patient apelin treatment facilit cell migrat invas inhibit tissu inhibitor metalloproteinas timp express increas mir p synthesi via c srcpikakt signal pathway control apelin regul timp product cell motil import apelin blockad inhibit prostat cancer metastasi orthotop mous model thus apelin promis therapeut target cure metastat prostat cancer
|
D054392;D000073861;D035683;D011471
|
T123;T191;T116;T114
|
36,291,150
|
high effici express system recombin human prolidas effect n termin tag enzym activ prolidas enzym hydrolyz dipeptid contain prolin hydroxyprolineat c terminus play import role collagen turnov human prolidas activ dimer c termin domain contain two mn ion activ site studi aim develop high effici express system recombin human prolidas rhpepd evalu effect n termin tag enzymat biolog activ optim bacteri express system optim purif procedur rhpepd includ two step rhpepd purif procedur base affin chromatographi ni ion bound chromatographi column ii gel filtrat possibl tag remov select digest proteas xa studi show high concentr iptgand high temperatur induct led fast stimul gene express result forc host intens fast product rhpepd result demonstr slow induct gene express low concentr induc factor temperatur longer induct time led effici protein product solubl fraction moreov studi prove presenc tag chang neither express pattern egfr downstream signal protein prolidas catalyt activ
|
D003094;D011392
|
T123;T122;T121;T116
|
36,291,149
|
rna sequenc intestin enterocyt pre post roux en gastric bypass reveal alter gene express relat enterocyt differenti restitut obes regul schlafen intestin line renew program fashion affect adapt surgic procedur gastric bypass
|
D020895;D015390;D009765;D047908;D002454;D005786
|
T061;T123;T116;T025;T045;T043;T047
|
36,291,148
|
soce machineri unbalanc knowledg left right ventricular pathophysiolog right ventricular failur rvf import prognost factor morbid mortal pulmonari arteri hypertens pah pulmonari hypertens ph caus left heart diseas howev right ventricl rv remodel understudi target specif therapi part explain lack basic knowledg rv remodel sinc physiolog hemodynam function rv differ left ventricl lv mechan lv dysfunct general rv albeit knowledg help understand rv remodel dysfunct store oper ca entri soce recent emerg particip lv cardiomyocyt ca homeostasi critic player ca mishandl patholog context paper highlight current knowledg soce contribut lv rv dysfunct soce molecul present compart relat lack studi rv dysfunct indic necess investig signific challeng come year
|
D018497;D006976
|
T046
|
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