PMID
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35.7M
36.4M
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36,291,584
elev extracellular hsp blunt heat shock respons sever covid patient hypothes critic ill patient sar cov infect insulin resist would present reduc heat shock respons hsr pathway involv proteostasi anti inflamm subsequ lead wors outcom higher inflamm work aim measur concentr extracellular hsp ehsp patient sever covid com...
D000086382;D003924
T047;T067
36,291,583
toxic essenti metal human health diseas special issu biomolecul call toxic essenti metal human health diseas repres follow previous special issu name toxic essenti metal human health diseas
D008670;D019216
T197;T196
36,291,582
role ion channel develop pulmonari arteri hypertens pulmonari arteri hypertens pah uncommon progress fatal diseas
D000081029;D006976
T047;T046
36,291,581
novel regulatori role hydrogen sulfid health diseas follow prof
D006862;D064426
T131;T197;T130;T123
36,291,580
transcriptom meta analysi confirm hidraden suppurativa pathogen triad upregul inflamm alter epitheli organ dysregul metabol signal hidraden suppurativa hs inflammatori skin condit clinic character recurr pain deep seat nodul abscess sinus track area bear apocrin gland axilla breast groin buttock despit mani recent adva...
D017497;D015843
T123;T047;T121;T116
36,291,579
delet growth hormon secretagogu receptor kisspeptin neuron femal mice block diet induc obes gut peptid ghrelin mediat energi homeostasi reproduct act receptor growth hormon secretagogu receptor ghsr express hypothalam neuron arcuat arc shown estradiol e increas ghsr express kisspeptinneurokinin bdynorphin kndi neuron e...
D054440
T116;T192
36,291,578
integr nanomet rang label label distanc distribut model approach label techniqu electron paramagnet reson spectroscopi singl molecul fluoresc reson energi transfer allow access distanc rang ten angstrom correspond size protein small medium size protein complex measur requir long rang order therefor applic system partia...
D011506
T123;T116
36,291,577
matrix metalloproteinas glaucoma matrix metalloproteinas mmps enzym decompos extracellular matrix ecm protein mmps thought play import role cellular process cell prolifer differenti angiogenesi migrat apoptosi host defens mmps distribut almost intraocular tissu involv physiolog patholog mechan eye mmps also associ glau...
D019636;D005901
T047
36,291,576
local perivascular therapeut approach inhibit venous neointim hyperplasia arterioven fistula access hemodialysi use arterioven fistula avf prefer vascular access chronic hemodialysi high failur rate restrict use optim patient periop status surgic techniqu among method prevent primari avf failur continu fall short lower...
D006435;D001164
T061;T190
36,291,575
prostat cancer associ mirna saliva first step easili access reliabl screen tool common diagnost tool prostat cancer prostat specif antigen transrect biopsi show low predict valu poor sensit studi examin circul mirna saliva explor possibl non invas easi execut diagnost tool prostat cancer screen
D011471;D035683
T123;T191;T114
36,291,574
myricetin potenti adjuv chemotherapi studi inhibit human glutathion transferas glutathion transferas gsts famili phase ii detoxif enzym involv develop multi drug resist mdr phenomena toward chemotherapeut agent gst inhibitor consid candid compound abl chemomodul revers mdr natur flavonoid myricetin myr shown exhibit wi...
D005419;D005982
T121;T116;T127;T109;T126
36,291,573
cisplatin resist genet epigenet factor involv cisplatin cddp drug choic differ type cancer howev tumor cell acquir resist damag caus cisplatin generat genet epigenet chang lead generat resist activ intrins resist mechan cancer cell among find mutat altern splice epigenet driven express chang even post translat modif pr...
D002945;D000970
T121;T197;T109
36,291,572
contagium vivum fluidum riboviria tobacco mosaic virus centric histori virus taxonomi virus discov agent diseas late th centuri natur agent elucid nevertheless soon viral diseas start recogn catalog attempt classifi name virus although earli attempt fail adopt nascent virolog communiti evid human compuls tri organ natu...
D014027;D014780
T005
36,291,571
liposom entrap chemic modif relaxin prolong stabil biolog activ relaxin rlx protein structur similar insulin interest biolog activ protein preserv rlx structur integritybiolog function problemat herein investig two method increas durat relaxin rlx biolog activ synthesi palmitoyl rlx conjug p rlx use palmitoyl l glu otb...
D012065;D061385
T125;T121;T116
36,291,570
glycosyl flavonoid compound potent cyp inhibitor mycobacterium tuberculosi due concern rise number multipl prolong drug resist mdr xdr mycobacterium tuberculosi mtb strain unpreced demand creat design develop novel therapeut drug higher efficaci safeti studi focus view implement silico drug design pipelin divers set gl...
D009169
T007
36,291,569
assess lipid qualiti commerci omega supplement sold french market supplement omega fatti acid consid valuabl strategi suppli low intak fatti acid thus safeti supplement import mileston analyz unflavor supplement sold french market fatti acid triglycerid composit epa dha tocol content well oxid status studi found supple...
D024508;D015525
T121;T123;T127;T109
36,291,568
antipsychot drug fluphenazin human cancer cell drug repurpos strategi speed find novel clinic use alreadi approv drug sever diseas cancer process acceler compar develop new drug compound alreadi test clinic trial data relat pharmacokinet alreadi describ reduc cost time associ develop new anticanc therapeut sever studi ...
D014150;D009369
T121;T039;T191
36,291,567
identif thyrotropin releas hormon trh novel biomark prognosi acut myeloid leukemia acut myeloid leukemia aml biolog genet heterogen hematolog malign unsatisfactori risk stratif system recent novel singl cell rna sequenc technolog reveal heterogen leukemia myeloblast runx runxt aml thyrotropin releas hormon trh biomark ...
D050676;D015470
T123;T191;T116
36,291,566
investig role zinc atherosclerosi review zinc indispens micronutri human health might play import role develop atherosclerosi zinc could involv atherogen process interact atherogen cell endotheli cell ec vascular smooth muscl cell vsmcs immun cell addit zinc also exert import posit negat function various atherosclerosi...
D042783;D050197
T047;T046;T025
36,291,565
role autophagi osteoarthrit cartilag osteoarthr oa one common diseas lead physic disabl age main risk factor degener articular cartilag main focus pathogenesi oa autophagi crucial intracellular homeostasi system recycl flaw macromolecul cellular organell sustain metabol cell grow evid reveal autophagi chondroprotect re...
D002358;D010003;D035683
T123;T047;T024;T114
36,291,564
function gait assess use manual semi autom deep learn approach follow standard model peripher nerv injuri mice develop standard model stretch crush sciatic nerv injuri mice compar outcom crush novel stretch crush injuri use standard manual gait sensori assay compar semi autom well deep learn gait analysi method
D059348;D000077321;D000071576
T066;T037
36,291,563
pulmonari thrombosi promot tumorigenesi via myeloid hypoxia induc factor cancer patient greater risk thrombosi individu without cancer convers thrombosi diagnost predictor cancer mechan thrombosi promot tumor propag incomplet understood previous studi show hypoxia induc factor hif hif stabil myeloid cell murin thrombi ...
D051792;D013939
T123;T126;T116
36,291,562
studi natur sar cov use shell disord model reproduc evolut spread attenu basic tenet shell disord model sdm appli covid harder outer shell virus shell lower pid percentag intrins disord membran protein pidm higher flexibl inner shell higher pid nucleocapsid protein n pidn correl contagi virul respect protect virion ant...
D000086402;D000086382
T005;T067;T047
36,291,561
phlpp inhibitor nsc neuroprotect rodent model cardiac arrest traumat brain injuri pleckstrin homolog domain leucin rich repeat protein phosphatas phlpp knockout mice improv outcom stroke traumat brain injuri tbi decreas maladapt vascular remodel follow vascular injuri thus small molecul phlpp inhibitor potenti improv n...
D006323;D000070642
T047;T046;T037
36,291,560
acut short term inhal carbon nanofib spragu dawley rat inhal toxic carbon nanofib cnfs clear known due relat relat studi report acut inhal studi short term inhal studi day therefor conduct use spragu dawley rat acut inhal studi rat group expos fresh air control low moder high mgm cnf concentr h thereaft sacrif day shor...
D057139
T073
36,291,559
teenag onset colorect cancer digen cancer predisposit syndrom provid clue interact mismatch repair polymeras proofread defici tumorigenesi colorect cancer crc adolesc young adult aya rare known predisposit syndrom includ lynch syndrom ls due high penetr mlh msh allel famili adenomat polyposi fap constitut mismatch repa...
D003123;D015179
T047;T191
36,291,558
biomolecular mechan cardioren protect sodium glucos co transport inhibitor diabet mellitus dm metabol disord character chronic hyperglycemia associ increas risk morbid mortal primarili cardiovascular renal diseas sodium glucos cotransport inhibitor sglt novel drug treatment type dm heart failur hf sglt mediat protect e...
D000077203;D003924;D003928;D006333;D002318
T121;T047;T046;T109
36,291,557
tumor treat field ttfield revers permeabil blood brain barrier vitro vivo despit avail numer therapeut substanc could potenti target cns disord inabl agent cross restrict blood brain barrier bbb limit clinic util novel strategi overcom bbb therefor need improv drug deliveri report first time tumor treat field ttfield a...
D001812;D005909
T023;T191
36,291,556
common mechan activ catalysi p loop fold nucleosid triphosphatas unit divers clarifi obscur hydrolysi mechan ubiquit p loop fold nucleosid triphosphatas walker ntpase analys structur catalyt site bound mg ntp complex analogu result present two articl second elucid whether walker walker b sequenc motif common p loop ntp...
D043583;D000074182
T087;T126;T116
36,291,555
human alpha antitrypsin suppress nf b activ extend lifespan adult drosophila human alpha antitrypsin haat multifunct protein shown anti inflammatori cellular protect properti previous studi demonstr antiag potenti haat mechan under antiag effect remain elus studi perform detail analysi transcriptom data indic nf b targ...
D000515;D008136
T123;T121;T116;T102;T079
36,291,554
common pattern hydrolysi initi p loop fold nucleosid triphosphatas p loop fold nucleosid triphosph ntp hydrolas also known walker ntpase function atpas gtpase atp synthas often medic import repres one largest evolutionarili oldest famili enzym still consensus catalyt mechan clarifi perform first compar structur analysi...
D043583;D000074182
T087;T126;T116
36,291,553
small peptid larg protein alzheimersdiseas alzheim diseas ad common neurodegen disord elder two cardin neuropatholog hallmark ad senil plaqu extracellular deposit main constitut beta amyloid neurofibrillari tangl form abnorm phosphoryl tau p tau locat cytoplasm neuron although research made relev progress manag diseas ...
D000544
T047;T048
36,291,552
gpcrs intracellular compart new target drug discoveri architectur eukaryot cell defin extens membran delimit compart entail separ metabol process would otherwis interfer lead function differ cell g protein coupl receptor gpcrs largest class cell surfac receptor signal transduct tradit view chain event initi plasma memb...
D043562;D055808
T062;T116;T192
36,291,551
potassium channel therapeut target pulmonari arteri hypertens pulmonari arteri hypertens pah devast diseas high morbid mortal deleteri remodel pulmonari arteri system lead irrevers arteri constrict elev pulmonari arteri pressur right heart failur eventu death difficulti treat pah stem part complex natur diseas pathogen...
D024683;D000081029;D053447;D006976;D024642
T123;T047;T046;T116
36,291,550
ractopamin center decad long scientif legal disput lesson benefit safeti issu conflict ractopamin rac synthet phenethanolamin adrenerg agonist use feed addit develop lean increas feed convers effici differ farm anim rac author feed addit pig cattl limit number countri great major jurisdict includ european union eu chin...
D000821;D034462
T168;T054
36,291,549
programm dna exclus guid argonaut dnase higher cleavag specif achiev hydroxyl guid argonaut protein exist wide eukaryot prokaryot great potenti molecular clone nucleic acid detect dna assembl gene edit howev overal properti satisfactori hinder broad applic herein investig prokaryot argonaut nucleas mesophil bacterium c...
D060565;D003851
T123;T121;T126;T116
36,291,548
implic nanoparticl combat chronic liver kidney diseas progress perspect liver kidney diseas frequent encount problem around globe damag liver kidney may occur result exposur various drug chemic toxin pathogen lead sever diseas condit cirrhosi fibrosi hepat acut kidney injuri liver renal failur regard use nanoparticl np...
D053768;D015034;D053758;D007674
T121;T197;T073;T047
36,291,547
liraglutid attenu glucolipotox induc rsc schwann cell inflamm dysfunct diabet neuropathi dn type sensori nerv damag occur patient diabet although understand pathophysiolog incomplet dn often associ structur function alter affect neuron among possibl caus nerv damag schwann cell scs thought play key role repair peripher...
D000069450;D003929
T121;T116;T109;T125;T047
36,291,546
curcumin target non code rnas colorect cancer therapeut biomark implic colorect cancer one common gastrointestin malign high incid rate low rate earli diagnosi complex pathogenesi recent year progress made diagnosi treatment method tumor malign prolifer metastasi treatment still serious affect surviv prognosi patient t...
D062085;D003474;D035683;D000970;D015179
T123;T121;T109;T191;T114;T130
36,291,545
emerg role non code rnas aortic dissect aortic dissect ad fatal cardiovascular acut diseas high incid mortal serious threaten patient live health pathogenesi ad main includ vascular inflamm extracellular matrix degrad phenotyp convers well apoptosi vascular smooth muscl cell vsmcs howev detail mechan still fulli elucid...
D062085;D035683;D000784
T123;T047;T046;T114
36,291,544
obtain reliabl diagnost biomark diabet mellitus standard salivari glucos measur salivari glucos frequent util diabet mellitus dm might propos potenti biomark candid dm non invas cost effect achiev adequ diagnost perform dm patient howev salivari glucos level may chang specif condit consequ essenti maintain consist stra...
D001786;D003924
T047;T109
36,291,543
stabil anti angiogen properti titanium dioxid nanoparticl tionp use caco cell titanium dioxid nanoparticl tionp found wide rang product sunscreen paint toothpast cosmet due white pigment high refract index wide rang applic could result direct indirect exposur nps human environ accord conflict level toxic associ nps the...
D053758;D000230;D015179
T191;T073
36,291,542
fingerprint benign cancer skin lesion use vibrat optic coher tomographi differenti among cancer lesion type base presenc new cell blood vessel fibrosi studi use vibrat optic coher tomographi voct examin morpholog stiff benign cancer lesion lesion imag plot weight displac versus frequenc depth use compar cellular dermal...
D012878;D055623;D008545
T191
36,291,541
associ matern diet pregnanc metabolit profil cord blood cord blood metabolit predict long term diseas risk level differ metabolit might vari respect matern diet well understood aim studi evalu associ differ dietari pattern pregnanc cord blood metabolit includ glycerophospholipid fatti acid polar lipid non esterifi fatt...
D005312;D004032
T168;T031
36,291,540
shorten hing design fab x sdab fc bispecif antibodi enhanc redirect cell kill tumor cell cell engag tce antibodi emerg promis cancer therapeut link cytotox cell tumor cell simultan bind cde cell tumor associ antigen taa express tumor cell previous report novel bispecif format igg like fab x sdab fc also known half igvh...
D018033;D061905;D009369
T129;T121;T191;T116
36,291,539
fibrillin regul arteriol integr retina fibrillin extracellular matrix protein assembl microfibril provid critic function larg blood vessel tissu mutat fibrillin gene associ cardiovascular ocular skelet abnorm marfan syndrom fibrillin compon wall larg arteri poor describ vessel examin microvasculatur retina use wild typ...
D008382
T047
36,291,538
radic mediat rapid vitro format c type cytochrom cytochrom c mutant thermus thermophilus hb rc ca report polypeptid replac cys alanin overexpress cytosol e coli apo form ca mutant apo ca without origin prosthet group obtain simpl chemic treatment retain compact conform amen reconstitut heme b zinc ii protoporphyrin ix ...
D011524;D004926
T123;T007;T109
36,291,537
anti phosphatidylethanolamin anti phosphatidylserin antibodi associ renal involv atherosclerosi cardiovascular manifest raynaud phenomenon diseas activ polish patient system lupus erythematosus evalu associ anti phosphatidylethanolamin ape anti phosphatidylserin ap antibodi cardiovascular risk organ involv diseas activ...
D016736;D008180;D050197;D011928;D015186
T047;T046;T015
36,291,536
ala peptid appropri scaffold remov redox silenc copper ion alzheim relat peptid progress neurodegen alzheim diseas ad widespread dementia due age popul current lack molecul abl prevent stop diseas ad even impact societi futur ad multifactori diseas among factor metal ion regard potenti therapeut target case redox compe...
D003300;D000544
T123;T121;T196;T047;T048
36,291,198
assess choroid vasculatur innat immun cell eye albino pigment mice visual choroid vasculatur innat immun cell eye pigment mice challeng due presenc retin pigment epithelium rpe layer separ choroid retina establish method visual choroid macrophag mast cell vasculatur eye albino pigment mice use cell type specif stain ab...
D002829;D008268
T023;T024;T047
36,291,197
lc dad esi msms nmr analysi conif wood special metabolit mani speci pinacea famili recogn rich sourc lignan flavonoid polyphenol great common occurr conif europ well use wood industri make plant materi industri wast materi easili access inexpens promis prognosi discoveri new activ compound well find new applic wood ind...
D044945;D064028;D013267;D017705
T121;T002;T109
36,291,196
induc pluripot stem cell step stone vitro human model hear loss hear loss preval sensorineur impair human yet despit activ research effect therapi cochlear implant reach clinic main reason failur multifactori natur disord heterogen late onset hinder identif etiolog factor anoth problem lack human sampl practic work con...
D057026;D034381;D003638;D007758;D000081015
T184;T025;T033;T023;T047;T046
36,291,195
high dimension cytometri dissect immunolog fingerprint idiopath inflammatori myopathi chronic inflamm skelet muscl common featur idiopath inflammatori myopathi iim given rariti diseas potenti difficulti routin obtain target tissu ie standard skelet muscl understand immun signatur iim spectrum remain incomplet insight i...
D009220;D018979
T047
36,291,194
mrna base approach treat liver diseas diseas affect liver account approxim million death worldwid year increas preval diseas limit efficaci current treatment expect stimul substanti growth global market therapeut target liver current liver transplant curat option avail mani liver diseas gene therapi repres valuabl appr...
D053758;D006528;D008113
T191;T073
36,291,193
iiig new protein exclus ciliari function analysi potenti role cancer patholog identif new protein regul function one main cellular phosphatas protein phosphatas pp essenti find possibl pharmacolog target alter phosphatas function various cellular process includ initi develop multipl diseas iiig regulatori subunit pp in...
D009369;D054645
T191;T126;T116
36,291,192
role cerevisia subpc transcript elong depend c termin region independ ssdna bind domain saccharomyc cerevisia sub scsub defin transcript stimulatori protein due homolog ssdna bind domain ssdbd human pc hpc recent pcsub orthologu elucid eukaryot prokaryot bacteriophag function relat dna metabol addit scsub contain uniqu...
D012441;D029701
T004;T116
36,291,191
critic review physiolog molecular featur bovin mammari gland develop recent advanc mammari gland uniqu organ abil undergo repeat cyclic chang throughout life mammal among domest livestock speci rumin cattl buffalo constitut distinct class livestock speci known milk produc cattl buffalo contribut total milk suppli world...
D002020;D042361
T023;T015;T024
36,291,190
synovi macrophag express oxl requir follicular helper cell differenti joint microenviron signal via oxoxl axi play key role cd cell develop oxl express primarili restrict antigen present cell apc studi design assess role apc mediat oxl express context develop rheumatoid arthriti ra associ cd cell subset analys clinic s...
D000084522;D001172
T047;T025
36,291,189
paracrin senesc mesenchym stromal cell involv inflammatori cytokin nf b pathway known senesc associ secretori phenotyp sasp trigger senesc surround normal cell howev sasp signal regard mesenchym stromal cell age remain fulli elucid therefor present studi aim clarifi molecular mechan late passag msc induc paracrin sasp ...
D016328;D059630
T129;T116;T025
36,291,188
nrf regul viabil prolifer resist oxid stress differenti murin myoblast muscl satellit cell increas oxid stress slow regener skelet muscl affect activ muscl satellit cell mscs therefor evalu role nrf transcript factor encod nfel gene main regul antioxid respons muscl cell biolog use immort murin myoblast cell line cc st...
D032496;D035683
T123;T025;T114
36,291,187
cop regul twiktrek heterodimer channel mediat passiv conduct astrocyt matur astrocyt character k conduct passiv conduct chang constant slope voltag involv k homeostasi brain recent report tandem pore domain weak inward rectifi k channel twik kcnk twik relat k channel trek kcnk form heterodimer channel mediat passiv con...
D001253;D024683
T123;T116;T025
36,291,186
spatial tempor divers astrocyt phenotyp spinocerebellar ataxia type mice astrocyt heterogen import featur healthi brain less understood spatiotempor heterogen astrocyt brain diseas spinocerebellar ataxia type sca progress neurodegen diseas caus cag repeat expans gene ataxin atxn character astrocyt across diseas progres...
D001253;D020754
T047;T025
36,291,185
therapeut target nf b acut lung injuri doubl edg sword acut lung injuryacut respiratori distress syndrom aliard devast diseas caus varieti condit includ pneumonia sepsi trauma recent covid although understand mechan aliard pathogenesi resolut consider increas recent year mortal rate remain unaccept high primarili due l...
D000086382;D055371;D012128
T047;T037;T067
36,291,184
dysregul cell cell communic character pulmonari fibrosi idiopath pulmonari fibrosi ipf progress diseas older adult character fibrot replac function gas exchang unit lung strongest risk factor ipf genet variantin promot region gel form mucin mucb better understand mucb variant influenc develop fibrosi use nichenet r pac...
D015850;D054990
T129;T047;T116
36,291,183
neutrophil extracellular vesicl delic balanc pro inflammatori respons anti inflammatori therapi extracellular vesicl ev releas extracellular environ cell activ apoptosi work signal transduc ev import mediat intercellular communic convoy protein nucleic acid lipid metabolit neutrophil extracellular vesicl nev contain mo...
D000067128;D009696
T026;T123;T114
36,291,182
recent advanc molecular therapeut corneal scar treatment process corneal wound heal complex induc scar format corneal scar lead caus blind worldwid fibrot heal major ocular wound disrupt high organ fibrillar collagen arrang corneal stroma render opaqu process regain organ extracellular matrix ecm arrang stromal layer r...
D065306;D035683
T033;T123;T037;T114
36,291,181
morbid mortal neutropen patient viscer surgeri narrat review leukocyt essenti function immun system cell cell interact human bodi hematolog diseas well chemotherapeut treatment due cancer lead occasion even perman leukocyt defici normal leukocyt neutrophil granulocyt leukopenia therefor most character decreas neutrophi...
D009503;D013505
T061;T047
36,291,180
gene enrich analysi astrocyt subtyp psychiatr disord psychotrop medic dataset astrocyt mani import function brain role psychiatr disord respons psychotrop medic still elucid use gene enrich analysi assess relationship differ astrocyt subtyp psychiatr diseas psychotrop medic antipsychot antidepress mood stabil also carr...
D014150;D001523
T121;T039;T048
36,291,179
low nephron number induc matern protein restrict prevent nicotinamid ribosid supplement depend sirtuin activ reduc nephron number birth due critic gestat condit includ matern malnutrit associ risk develop hypertens chronic kidney diseas adulthood intervent current avail augment nephron number recent shown sirtuin sirt ...
D056566
T126;T116
36,291,178
inhibit cell uptak delta omicron sar cov pseudovirus n acetylcystein irrespect oxidoreduct environ bind sar cov spike cell receptor angiotensin convert enzym ace crucial target prevent therapi covid explor involv oxidoreduct mechan investig effect oxid antioxid virus uptak ace express cell human origin ace hek cell upt...
D000085962;D000086382
T047;T126;T116;T067
36,291,177
musashi mir precursor interact mediat synergist oncogen induc co infect two avian retrovirus synerg avian leukosi virus subgroup j alv j reticuloendotheliosi virus rev report frequent co infect chicken flock although signific progress made understand tumorigenesi mechan alv rev two simpl oncogen retrovirus induc synerg...
D060085;D011201;D001354;D035683
T123;T047;T005;T114
36,291,176
genom amplif ubqln prognost treatment resist factor ubiquilin ubqln proteasom shuttl factor direct bind ubiquityl protein deliv cargo proteasom degrad previous show upregul ubqln determin dna damag respons ddr degrad mrea howev regulatori mechan dna level transcript post transcript level control ubqln mrna level remain...
D011815;D010051
T123;T191;T114
36,291,175
fama famili sequenc similar member cell densiti regul protein promot prolifer migrat cervic cancer cell fama famili sequenc similar member gene controversi discuss possess pro anti tumorigen potenti analyz regul cellular fama protein level studi function role fama hpv posit cervic cancer cell find fama protein express ...
D002583;D009856;D030361
T123;T047;T191;T116
36,291,174
pan cancer analysi prognost immunotherapeut valu mitd microtubul interact traffick domain contain mitd associ absciss cytokinesi howev systemat investig role cancer lack therefor explor pan cancer role mitd use multipl databas express clinic surviv immunolog enrich analys perform use r packag onlin tool breast cancer s...
D000082082;D001943
T129;T121;T191;T043
36,291,173
novel self form nanos dds particl bnct util hydrophob boron cluster molecular glue effect bnct non invas cancer therapi allow cancer cell death without harm adjac cell howev applic limit owe challeng work clinic approv boron b compound drug deliveri system dds address issu develop self form nanoparticl consist biodegra...
D001895;D016754
T061;T196
36,291,172
monitor nlrp inflammasom activ exhaust clinic sampl refin flow cytometri protocol asc speck format measur direct whole blood ex vivo stimul alter nlrp inflammasom pathway includ hyper activ exhaust implic pathophysiolog mani diseas follow cell stimul aggreg asc protein multiprotein complex asc speck propos specif read ...
D058847;D000071199
T123;T116
36,291,171
exosom plasma gelsolin immunosuppress mediat ovarian tumor microenviron determin chemoresist ovarian cancer ovca fatal gynecolog cancer year surviv rate less main due late diagnosi drug resist overexpress plasma gelsolin pgsn key contribut factor ovca chemoresist immunosuppress gelsolin gsn multifunct protein regul act...
D010051;D000970
T121;T191;T109
36,291,170
transplant human fetal spinal cord deriv npcs prime polyglutam conjug rhorock inhibitor acut spinal cord injuri neural precursor cell npc transplant repres promis therapi treat spinal cord injuri scis howev despit success result obtain preclin model clinic translat approach remain challeng due part lack consensus optim...
D011099;D013119;D017690
T061;T116;T037
36,291,169
prolong suppress neuropath hypersensit upon neurostimul posterior insula mice neurostimul base therapeut approach emerg altern pharmacolog drug need develop optim efficaci reduc variabl despit key relev pain insular cortex explor cortic neurostimul approach develop approach perform repetit transcrani direct current sti...
D065908;D009437;D009044
T061;T184;T029;T023;T047
36,291,168
predict progress autosom domin polycyst kidney diseas chang telomer epigenom autosom domin polycyst kidney diseas adpkd common inherit caus chronic kidney diseas polycystin amp nbsp pkd gene mutat howev intra famili variabl symptom suggest non mendelian contribut diseas goal find marker track epigenet chang common rapi...
D016891;D062085
T019;T047;T123;T114
36,291,167
ferroptosi shed light mechan therapeut opportun liver diseas cell death vital physiolog patholog phenomenon develop process organ ferroptosi kind newli discov regul cell death rcd differ rcd pattern apoptosi necrosi autophagi morpholog biochem genet level kind iron depend mode death mediat lipid peroxid lipid reactiv o...
D000079403;D008107
T033;T047;T043
36,291,166
smurf suppress enhanc temozolomid chemosensit glioblastoma facilit pten nuclear transloc tumor suppressor pten main inhibit pikakt pathway cytoplasm maintain dna stabil nucleus status pten remain therapeut effect chemoresist dna alkyl agent temozolomid tmz glioblastoma gb howev under mechan pten interconnect role cytop...
D005909
T191
36,291,165
strategi brain maintain forc product pain contract motor unit pool reorgan common symptom neuromuscular diseas pain chang human movement mani way use decompos electromyograph signal investig strategi brain recruit differ pool motor unit mus produc torqu induc muscl pain term fire rate fr recruit threshold rt action pot...
D018482;D009046
T023;T025;T024
36,291,164
iron oxid nanoparticl combin static magnet field bone remodel iron oxid nanoparticl ionp extens use bone relat studi biomateri due uniqu magnet properti good biocompat endocytosi ionp enter cell promot osteogen differenti inhibit osteoclastogenesi static magnet field smfs also found enhanc osteoblast differenti hinder ...
D010012;D060526
T070;T042
36,291,163
modul neutrophil activ solubl complement cleavag product depth analysi cellular fluid phase innat immun respons mani diseas predomin involv activ neutrophil granulocyt complement factor howev compar systemat analysi earli impact key solubl complement cleavag product includ anaphylatoxin neutrophil granulocyt function l...
D009504;D000706
T123;T116;T025;T131
36,291,162
polyubiquitin sumoyl site regul stabil zo protein seal tight junction tight junction tjs regul transit ion molecul paracellular pathway epitheli cell zonula occluden zo cytoplasm tj protein studi ubiquitin hzo employ mutant sumoyl site k present guk domain putat ubiquitin residu k k locat guk domain prolin rich region ...
D019108;D058207
T044;T030
36,291,161
human stem cell deriv brain liver chip assess blood brain barrier permeat pharmaceut drug signific advanc field preclin vitro blood brain barrier bbb model achiev recent year develop monolay base cultur system toward complex multi cellular assay coupl model relev organoid system integr investig blood brain barrier perm...
D001812;D057026;D004364
T121;T023;T025
36,291,160
new approach method hazard identif case studi azol fungicid affect molecular target associ advers outcom pathway cholestasi triazol fungicid propiconazol pi tebuconazol te show hepatotox vivo eg hypertrophi vacuol liver cell follow interact nuclear receptor pxr pregnan x receptor car constitut androstan receptor accord...
D005659;D000073931;D002779
T131;T047;T067
36,291,159
usp induc chemoresist tripl negat breast cancer via deubiquitin stabil abcb tripl negat breast cancer tnbc account breast cancer tnbc express estrogen receptor progesteron receptor human epiderm growth factor receptor cytotox chemotherapi surgeri current therapeut strategi tnbc patient chemoresist tnbc limit effici str...
D064726
T191
36,291,158
map univers eph receptor ephrin ligand transcript epitheli fiber cell eye len eye len transpar ellipsoid organ anterior chamber eye requir fine focus light onto retina transmit clear imag cataract defin opac len remain lead caus blind world recent studi human mice indic eph ephrin bidirect signal import maintain len tr...
D036104;D007908;D002386
T116;T190;T192;T033;T023;T126;T047
36,291,157
endophyt mediat stress toler plant sustain strategi enhanc resili assist crop improv biotic abiot stress sever affect agricultur affect crop product soil fertil health stress may signific financi repercuss necessit practic cost effect ecolog friend approach lessen negat impact plant sever agrochem fertil pesticid insec...
D060026;D007306
T131;T004
36,291,156
unravel differenti transcriptom cell type zebrafish larva intestin liver zebrafish intestin liver vertebr deriv endoderm great effort devot deciph molecular mechan control specif develop zebrafish intestin liver howev genom wide comparison transcriptom two organ larval stage remain unexplor lack extens identif featur g...
D015027;D059467
T081;T086;T013
36,291,155
vitro cell death mechan induc dicoma anomala root extract combin znpcs mediat photodynam therapi lung cancer cell global lung cancer remain lead caus morbid mortal men women enhanc photodynam therapeut effect vitro present studi design reduc dose depend photodynam therapi pdt evalu anticanc effect dicoma anomala anomal...
D010778;D008175
T061;T191
36,291,154
dendrit cell macrophag microenviron human clear cell renal cell carcinoma imprint mosaic myeloid subtyp associ patient surviv sinc initi descript eli metchnikoff phagocyt spark interest varieti biolog disciplin import cell perform central function tissu repair immun activ well toler myeloid cell immunoinhibitori partic...
D002292;D007680;D001688
T121;T123;T191
36,291,153
intracellular metabolom identifi efflux transport inhibitor routin caco cell permeabl assay biolog implic caco screen routin use laboratori measur permeabl compound identifi substrat efflux transport studi hypothes efflux transport inhibit compound predict intracellular metabol signatur caco cell assay use test intesti...
D027425;D013940
T123;T126;T116
36,291,152
come age btk inhibitor therapi review zanubrutinib waldenstrm macroglobulinemia waldenstrm macroglobulinemia wm rare form non hodgkin b cell lymphoma variabl clinic present impact patient qualiti life caus anemia peripher neuropathi serum hyperviscos extramedullari diseas symptom sever safe effect treatment regimen pat...
D008258;D016393
T191
36,291,151
apelin promot prostat cancer metastasi downregul timp via increas mir p express prostat cancer common affect urinari tract men metastat prostat cancer low surviv rate apelin belong famili adipokin associ cancer develop metastasi howev effect apelin prostat cancer metastasi undetermin analysi databas reveal posit correl...
D054392;D000073861;D035683;D011471
T123;T191;T116;T114
36,291,150
high effici express system recombin human prolidas effect n termin tag enzym activ prolidas enzym hydrolyz dipeptid contain prolin hydroxyprolineat c terminus play import role collagen turnov human prolidas activ dimer c termin domain contain two mn ion activ site studi aim develop high effici express system recombin h...
D003094;D011392
T123;T122;T121;T116
36,291,149
rna sequenc intestin enterocyt pre post roux en gastric bypass reveal alter gene express relat enterocyt differenti restitut obes regul schlafen intestin line renew program fashion affect adapt surgic procedur gastric bypass
D020895;D015390;D009765;D047908;D002454;D005786
T061;T123;T116;T025;T045;T043;T047
36,291,148
soce machineri unbalanc knowledg left right ventricular pathophysiolog right ventricular failur rvf import prognost factor morbid mortal pulmonari arteri hypertens pah pulmonari hypertens ph caus left heart diseas howev right ventricl rv remodel understudi target specif therapi part explain lack basic knowledg rv remod...
D018497;D006976
T046