PMID
int64 35.7M
36.4M
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36,288,110
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aug iuga joint clinic consensus statement enhanc recoveri urogynecolog surgeri develop joint write group intern urogynecolog associ american urogynecolog societi individu write group member note acknowledg section enhanc recoveri surgeri era evid base protocol periop care lead improv clinic outcom cost save articl aim present consensus recommend optim periop manag patient undergo urogynecolog surgeri
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D000932;D053610
|
T121;T039;T131;T109
|
36,288,105
|
negat electrospray supercharg mechan nucleic acid structur spray physiolog ionic strength nucleic acid typic end low level charg compact conform increas electrospray negat charg nucleic acid preserv nativ noncoval interact help distinguish solut fold ion mobil mass spectrometri get fundament insight supercharg mechan nucleic acid negat mode studi model g quadruplex structur singl strand control mm ammonium acet found ad propylen carbon sulfolan nba induc nativ supercharg howev although nba show highest supercharg abil induc unwant unfold solut fold g quadruplex supercharg effect resembl effect lower ionic strength could explain partial neutral ampholyt droplet becom concentr nonaqu compon supercharg abil rank pc sulfolan nba nba adduct g quadruplex high charg state confirm supercharg agent interact direct dna surpris presenc supercharg agent negat charg state also bear alkali metal ion adduct larger droplet known result counterion adduct result consist nativ supercharg condit produc larger droplet evapor charg residu howev negat charg carrier electrolyt becom rare chain eject accompani denatur henc non nativ supercharg becom predomin
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D021241;D009696
|
T123;T059;T114
|
36,288,096
|
descript halosolutus amylolyticus gen nov sp nov halosolutus halophilus sp nov halosolutus gelatinilyticus sp nov genom base taxonomi genera natribaculum halovarius three extrem halophil archaeal strain lt sqt wlhs isol gobi salin soil salt lake china strain relat genera natribaculum halovarius similar show low similar genera within famili natrialbacea base rrna gene phylogenom analysi confirm three strain form distinct clade separ relat genera halostagnicola natronococcus indic may repres novel genus famili natrialbacea averag nucleotid ident ani silico dna dna hybrid ddh averag amino acid ident aai valu among three strain respect much lower threshold valu speci demarc major phospholipid three strain phosphatid acid pa phosphatidylglycerol pg phosphatidylglycerol phosphat methyl ester pgp glycolipid profil three strain divers sulfat mannosyl glucosyl diether dgd disulf mannosyl glucosyl diether dgd found strain lt wlhs mannosyl glucosyl diether dgd dgd strain sqt combin phenotyp chemotaxonom phylogenet genom analys suggest strain wlhs cgmcc jcm sqt cgmcc jcm lt cgmcc jcm repres three novel speci new genus within famili natrialbacea name halosolutus amylolyticus gen nov sp nov halosolutus gelatinilyticus sp nov halosolutus halophilus sp nov propos genom base classif genera natribaculum halovarius reveal halovarius luteus transfer genus natribaculum natribaculum luteum comb nov natribaculum longum heterotyp synonym natribaculum breve liu et al
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D005227;D006216
|
T194;T123;T168;T109
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36,288,095
|
bacteri secret growth medium stimul mous respiratori innat immun respons introduct find safe innat immun respons stimul one greatest challeng face immunologist vaccin manufactur gap statement role steril bacteri secret sbss pseudomona aeruginosa stimul innat immun respons investig previous aim compar effect sbss bacteri cell p aeruginosa isol isol freshwat pae infect wound pac respiratori tract innat immun respons methodolog four test mice group instil intranas cfu pac cfu pae sbs pac sbs pae two control group given either lb broth pbs time cours chang il beta mrna tnf alpha mrna il tnf leukocyt count bacteri uptak intracellular bacteri kill mous alveolar macrophag am histolog chang examin lung bacteri burden count first second test group result maximum level il seen earli h pg ml post instil sbs pac h pgml post instil sbs pae maximum level tnf seen earli h pg ml post instil sbs pac pg ml post instil sbs pae valu almost line il tnf gene express moder infiltr leukocyt bronchoalveolar lavag bal lung section moder activ am bacteri uptak bacteri kill observ innat immun respons paramet mice instil pac pae higher p mice group instil sbss pac persist lung mice h log cfu g h log cfu g pae conclus administr mice sbs stimul cellular molecular arm innat immun respons respiratori tract open door possibl use sbs p aeruginosa adjuv
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D014409;D008168
|
T129;T023;T116
|
36,288,093
|
ginsenosid rg inhibit biofilm format haemolyt activ f staphylococcus aureus inhibit saersa two compon system introduct staphylococcus aureus major caus chronic diseas biofilm format contribut factor ginsenosid rg rg natur product extract tradit chines medicin red ginseng gap statement effect rg biofilm format haemolyt activ well antibacteri mechan aureus report aim studi aim investig effect rg biofilm format haemolyt activ well antibacteri action clinic aureus isol methodolog effect rg biofilm format clinic aureus isol studi crystal violet stain haemolyt activ analysi carri furthermor influenc rg proteom profil aureus studi quantit proteom clarifi mechan under antibacteri action verifi revers transcript quantit real time polymeras chain reaction rt qpcr result rg signific inhibit biofilm format haemolyt activ clinic aureus isol total fold chang express identifi includ upregul protein downregul protein base bioinformat analysi express sever virul factor biofilm relat protein contain copz cspa sasg saersa two compon system saersa regul protein includ leukocidin like protein immunoglobulin bind protein g sbi fibrinogen bind protein aureu rg treat group downregul rt qpcr confirm rg inhibit regul saersa decreas transcript level biofilm relat gene c opz cspa sasg conclus rg reduc format biofilm reduc cell adhes aggreg rg inhibit saersa two compon system act crucial signal transduct system anti virul activ rg clinic aureus isol
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D013203;D001688
|
T123;T047;T121
|
36,288,091
|
dilemma way bacteri biofilm research biofilm associ infect bai common clinic practic becom public health problem global concern present view current research detect method mechan research anim model construct treatment strategi etc biofilm bai discuss futur develop concern import issu
|
D018441;D001424
|
T047;T007
|
36,288,090
|
pulmonari atresia intact ventricular septum radiofrequ perfor transcathet pulmonari valv intend describ entir transcathet manag pathway patient pulmonari atresia intact ventricular septum paiv
|
D011664;D018633
|
T023;T047
|
36,288,088
|
discoveri trifluoromethoxi cyclopentanon benzothiazol receptor interact protein kinas inhibitor treatment alzheim diseas receptor interact protein kinas ripk contribut broad set inflamm necroptosi human diseas also play import role pathogenesi alzheim diseas ad inhibit ripk could novel strategi improv cognit function szm high specif ripk inhibitor k ripk nm k ripk nm develop group superior high antinecroptot activ ec nm investig complet revers tumor necrosi factor induc system inflammatori respons syndrom streptozocin induc ad like mous model behavior test show szm appar amelior learn memori dysfunct nissl stain reveal szm improv neuron loss moreov tau hyperphosphoryl neuroinflamm ripk phosphoryl level hippocampus cortex signific decreas szm treat group collect szm repres promis lead structur discoveri novel ripk inhibitori anti ad agent
|
D000544
|
T047;T048
|
36,288,087
|
granulimona faecali gen nov sp nov leptogranulimona caecicola gen nov sp nov novel lactat produc atopobiacea bacteria isol mous intestin emend descript famili atopobiacea two strict anaerob gram stain posit non motil bacteria strain opf toc isol mous intestin strain opf toc grew ph respect temperatur c cell morpholog strain short rod rod respect cell possess intracellular granul major cellular fatti acid opf c cis c cis dimethyl acet wherea toc c c cis opf main end product modifi pepton yeast extract glucos pyg ferment lactat format butyr wherea addit acid toc also produc hydrogen genom opf toc respect mbp size dna gc content rrna gene sequenc opf toc show highest similar member famili atopobiacea name olsenella phocaeensi marseill p olsenella umbonata kctc respect phylogenet analys reveal isol form distinct lineag genera famili atopobiacea addit two strain character relat low rrna gene sequenc similar distinguish distinct trait includ cell shape dna gc content major fatti acid profil basi polyphas taxonom properti isol repres two noel speci two novel genera within famili atopobiacea name granulimona faecali gen nov sp nov opf jcm kctc leptogranulimona caecicola gen nov sp nov toc jcm kctc propos
|
D019344;D010461
|
T123;T121;T116;T109;T130
|
36,288,084
|
littl skate genom provid insight genet program essenti limb base locomot littl skate leucoraja erinacea cartilagin fish display pelvic fin driven walk like behavior use genet program neuron subtyp similar land vertebr howev mechanist studi littl skate motor circuit develop limit due lack high qualiti refer genom generat assembl littl skate genom precis gene annot structur allow post genom analysi spinal motor neuron mns essenti locomot interspeci comparison mous skate chicken mn transcriptom share diverg gene express profil identifi comparison access chromatin region mous skate mns predict share transcript factor tf motif diverg one could use achiev differenti regul mn express gene greater number tf motif predict observ mn express gene mous littl skate find suggest conserv diverg molecular mechan control mn develop vertebr evolut might contribut intric gene regulatori network emerg sophist motor system tetrapod
|
D012860
|
T013
|
36,288,079
|
systemat score system determin long term prognosi sever damag teeth mani criteria common consid treatment plan sever damag teeth well known clinician howev systemat approach decis make lack purpos articl introduc quantit systemat risk assess score system rass determin long term prognosi sever damag teeth base sever import factor treatment decis made dentist take account role system paramet medic condit patient smoke status psycholog factor patient expect regard durat overal cost treatment periodont health assess local factor emphasi place paramet crown root ratio root condit risk furcat involv complex final restor esthet result propos rass paramet rank use color code level risk optim green favor blue unfavor yellow hopeless red presenc even paramet red zone suffici consid tooth extract paramet red zone final decis made possibl effect clinic condit weigh overal risk treatment failur determin clinic decis make regard preserv extract sever damag teeth challeng multifactori process rass introduc articl focus main factor simplifi organ decis make process howev mani paramet may affect final treatment decis moreov decis make system definit appli clinic scenario entir process depend knowledg experi expertis clinician
|
D010347;D014070
|
T058;T023
|
36,288,078
|
digit intraor imag analysi retak reduct radiat exposur use rectangular collim purpos studi examin distribut extent retak digit intraor imag oper transit use round rectangular collim determin effect collim shape radiat exposur patient studi conduct use digit intraor radiograph data dental school radiolog clinic digit intraor radiographi perform round collim rectangular collim cohort student exposur valu obtain effect dose calcul although number retak increas transit round rectangular collim transit also result statist signific reduct overal effect dose patient p pearson chi squar test averag differ round rectangular collim even increas number retak decreas effect dose observ rectangular collim use retak due placement error defin miss contact point miss apic teeth miss area interest student gain experi practic rectangular collim number retak decreas proper clinic didact train emphasi import rectangular collim transit round rectangular collim achiev minim initi increas retak subsequ normal rate result signific reduct radiat dose patient
|
D019252;D000069079
|
T060;T037
|
36,288,077
|
earli detect oral potenti malign disord use machin learn retrospect pilot studi earli diagnosi oral potenti malign disord opmd may hinder similar clinic present share benign oral lesion opmd goal retrospect pilot studi assess use machin learn ml adjunct evalu conjunct convent comprehens oral examin ompd digit imag deidentifi intraor lesion benign intraor lesion opmd collect imag previous identifi independ experienc oral pathologist use creat dataset raw imag grayscal imag enhanc color imag dataset subsequ divid train n test n valid n group class label benign lesion ompd distribut equal group cross valid grid search use optim hyperparamet extrem gradient boost xgboost classif model predict made test group use optim predict threshold final result valid predict base valid group xgboost classif model abl differenti benign intraor lesion opmd mean classif accuraci sensit specif grayscal enhanc color intraor imag use mean classif accuraci sensit specif observ raw intraor imag use result demonstr ml may promis tool diagnosi opmd use adjunct convent comprehens oral examin
|
D009062;D011230;D009059
|
T047;T191
|
36,288,076
|
waistlin gumlin retrospect analysi bodi mass index treat periodont patient undergo periodont mainten therapi periodont diseas affect adult unit state periodont microbiom host immun inflammatori respons may influenc overweightobes status retrospect analysi sought determin associ periodont diseas paramet bodi mass index bmi obes status patient undergo periodont mainten therapi record patient undergo periodont mainten periodont treatment examin patient demograph characterist sex age raceethn self report bmi periodont diseas condit number site probe depth mm miss teeth site bleed probe bop record patient determin activ moder sever periodont present site differ quadrant clinic attach loss mm probe depth mm individu also categor group underweightnormoweight bmi overweight bmi obes bmi studi popul bmi rang periodont status signific associ bmi status overweight odd ratio ci obes ci femal sex ci age ci negat associ activ periodont status obes patient demonstr signific site bop either underweightnormoweight overweight patient bmi indic obes associ increas age p higher number miss teeth p popul patient undergo periodont mainten therapi bmi associ age miss teeth obes status associ signific higher number site bop
|
D010518;D016388;D010510
|
T047;T020
|
36,288,075
|
dental eros indic gastroesophag reflux diseas evid show dental eros de often caus gastroesophag reflux diseas gerd relationship de sever patient symptom receipt appropri medic treatment gerd clear understood purpos studi evalu associ de gerd eighti particip underw basic eros wear examin de complet patient report outcom measur inform system promi survey symptom gastrointestin reflux promi scale v gastrointestin gastroesophag reflux english patient observ eros pattern refer gastroenterolog evalu associ de gerd assess use multipl regress result show extent de posit associ gerd symptom b ci measur promi survey particip without current diagnosi gerd patient studi sever de evalu gastroenterolog depart diagnosi gerd establish deni past histori diseas twenti patient gerd underw upper endoscopi esophag lesion found patient eros esophag barrett esophagus patient clinic identifi de may benefit medic evalu necessari manag gerd subset patient de may clinic indic untreat undertr gerd could lead serious esophag chang dentist consid refer patient de primari care provid gastrointestin specialist ensur system condit identifi manag appropri
|
D005764;D004942;D001471
|
T047
|
36,288,074
|
evalu fluorid calcium concentr drink water public water fountain univers campus optim exposur fluorid calcium tap water benefici dental cari prevent water fountain may import sourc drink water work educ set aim studi quantifi fluorid calcium concentr drink water sampl collect public water fountain indiana univers purdu univers indianapoli campus compar fluorid calcium concentr water collect differ time determin whether presenc absenc visibl extern filter affect fluorid calcium concentr nineti sampl collect water fountain access public duplic sampl collect month later fluorid ion select electrod use conjunct ion specif meter determin fluorid concentr atom absorpt spectrometri air acetylen flame implement quantifi calcium concentr fluorid calcium concentr drink water sampl display rang mgl mgl mgl mgl respect concentr fluorid calcium drink water slight lower second collect period p wilcoxon sign rank test statist signific differ observ fluorid calcium concentr drink water collect water fountain extern filter cartridg comparison fountain filter fluorid concentr within optim rang recommend us public health servic fluorid drink water calcium concentr consist report previous surveil studi
|
D060766;D003731
|
T033;T047;T167
|
36,288,073
|
scan electron microscop evalu microgap size mors taper implant straight angl abut aim studi compar size implant abut microgap mors taper implant straight abut isa group mors taper implant angl abut iaa group total mors taper dental implant mm use respect abut abut angl straight implant abut unit immers epoxi resin form base cross section volum remov specimen analyz scan electron microscop size microgap measur region side implant total measur per specimen mann whitney u kruskal walli test use statist analysi isa group statist signific differ median size microgap differ region interfac p kruskal walli test mean sd valu largest smallest microgap isa group respect iaa group statist signific differ median size microgap upper middl region left side p kruskal walli test mean sd valu largest smallest micrograp respect comparison differ region isa iaa group reveal statist signific differ lower region right side p mann whitney u test size microgap isa iaa group statist similar overal analysi p mann whitney u test howev iaa group show greater seal abil addit group vitro titanium oxid format observ interfac character type cold weld joint provid effect implant abut seal
|
D059605;D015921
|
T170;T074;T082
|
36,288,072
|
nasal airway obstruct orofaci pain multicent retrospect analysi aim studi investig relationship nasal airway obstruct nao symptom orofaci pain includ temporomandibular joint patholog primari headach studi retrospect analysi consecut patient seek care chronic orofaci pain north american treatment center standard evalu protocol follow patient includ cone beam comput tomographi cbct comprehens clinic examin thorough review patient subject complaint health histori includ pain sleep patholog primari condit interest studi follow type nao nasal valv compromis nvc deviat septum septal swell bodi concha bullosa inferior turbin soft tissu hypertrophi descript statist regress analysi perform determin comorbid orofaci pain symptom nao observ cbct imag studi popul consist patient men women mean age patient sd year nvc preval type nao found studi popul n nvc show statist signific comorbid capsul odd ratio well facial cervic myositi odd ratio author knowledg first time comorbid identifi nao high comorbid orofaci pain specif nvc major contributor nao understand mechan orofaci pain well effect improp mouth breath adapt forward head postur muscular fatigu parafunct temporomandibular joint patholog help clinician evalu role patient nose may play orofaci pain
|
D015508
|
T033;T047
|
36,288,071
|
oral cutan pemphigus vulgari atyp clinic present pemphigus vulgari pv rare pain blister autoimmun mucocutan disord appear middl age adult oral lesion typic preced cutan involv tend recalcitr therapi object articl present case oral cutan pv atyp patient year old woman case distinguish patient age decad younger report mean age onset coincid celiac diseas immunopatholog process rare seen associ pv intraven administr monoclon antibodi rituximab provid rapid clinic improv cutan lesion gradual improv oral lesion infus dental practition remain vigil oral manifest dermatolog diseas refer affect patient appropri healthcar provid long term manag
|
D010392;D001327
|
T047
|
36,288,070
|
malpractic alleg among us dentist associ malpractic alleg sever alleg malpractic injuri object studi explor associ alleg malpractic sever alleg malpractic injuri public use data file nation practition data bank use identifi dentist malpractic report januari decemb univari descript analysi conduct identifi frequenc malpractic alleg classifi sever alleg malpractic injuri practition graduat year year origin report process ordin logist regress analys conduct explor associ malpractic alleg type sever alleg malpractic injuri total valid report use analysi compar treatment relat alleg surgeri relat alleg prove time like result minor perman injuri diagnosi relat alleg time like result signific perman injuri time like result major perman injuri anesthesia relat alleg time like result major perman injuri confound variabl graduat year prove signific respect major temporari minor perman injuri alleg group advanc diagnosi relat anesthesia treatment surgeri relat alleg odd higher sever injuri increas establish proper diagnosi develop treatment plan manag anticip complic procedur perform critic success outcom
|
D008318
|
T080
|
36,287,990
|
peptid isol amphibian skin secret emphasi antimicrobi peptid skin amphibian tissu biolog function defens respir excret recent year research discov larg number peptid skin secret amphibian includ antimicrobi peptid antioxid peptid bradykinin insulin releas peptid peptid review focus origin primari structur secondari structur length function peptid secret amphibian skin hope review provid inform promot studi amphibian skin secret order provid refer expand research applic amphibian bioactiv peptid
|
D000089882;D061385
|
T121;T116
|
36,287,989
|
cyclosporin sourc novel insecticid product control spodoptera frugiperda fall armyworm faw spodoptera frugiperda caus substanti annual agricultur product loss worldwid due resist mani insecticid therefor new insecticid urgent need effect control faw cyclosporin csa secondari metabolit fungi littl known insecticid activ especi control faw studi demonstr csa show excel insecticid activ lc gg faw signific suppress calcineurin activ new target pest control combin csa indoxacarb emamectin benzoat vipaa show independ synergist toxic faw howev combin csa chlorantraniliprol show toxic subleth dose csa led decreas faw larval pupal weight pupat emerg mate rate adult longev extend develop faw larva pupa pre oviposit period adult increas proport pupal malform import csa treatment reduc faw ovarian size femal fecund suggest great potenti suppress faw coloni format taken togeth result indic csa high potenti insecticid control faw
|
D007306
|
T131
|
36,287,988
|
cytotox effect cannabidiol neonat rat cortic neuron astrocyt potenti danger brain develop influenc cannabidiol cbd brain develop inadequ understood sinc cbd consid non intox drug attract great interest concern potenti medic applic includ pregnant women children elucid respons perinat rat cortic neuron astrocyt cbd submicromolar concentr attain human effect cbd concentr time depend cell specif neuron cbd induc earli transient chang mitochondri membran potenti atp deplet caspas activ follow rapid atp recoveri progress activ caspas caspas result earli apoptot cell death reduct shorten dendrit cell shrinkag chromatin condens decreas neuron viabil atp deplet caspas activ due cbd exposur prevent transient receptor potenti vanilloid trpv antagonist astrocyt cbd caus immedi short term dysregul follow atp deplet transient activ caspas progress activ caspas caspas lead earli apoptosi subsequ necroptosi astrocyt trpv cannabinoid receptor cb antagonist protect viabil prevent apoptosi given cbd non intox drug result clear show case critic period brain develop signific interfer endogen cannabinoid system
|
D002185;D000970
|
T121;T109
|
36,287,987
|
french scorpion mainland oversea territori narrat review scorpion speci scorpion venom envenom manag sixti seven scorpion speci describ franc territori found heterogen distribut inde one speci found runion island speci exist french guiana number sting also heterogen sting per inhabit occur annual scorpion speci frequent determin simpl visual factor includ speci medic import ie buthus centruroid tityus scorpion venom compos local enzym peptid cystein stabil motif natx ktxs calcin allow venom diffus prey incapacit respect harm scorpion speci limit centruroid pococki french west indi induc sever envenom tityus obscurus tityus silvestri french guiana caus fatal children induc sever envenom respect envenom one scorpion requir hospit monitor long system symptom persist typic manag includ use lidocain patch pain killer local antisept case heart failur use dobutamin improv surviv pregnant women must consult obstetrician elev risk preterm birth stillbirth franc scorpion antivenom scorpion sting general fatal
|
D065008;D012604;D047928
|
T123;T116;T131;T037;T046
|
36,287,986
|
co occurr staphylococcus aureus ochratoxin pasteur milk pathogen mycotoxin serious public health risk human food safeti milk studi concentr detect staphylococcus aureus ochratoxin ota pasteur milk ten urban beij district suggest co occurr aureus toxin produc gene ota milk possibl risk aureus identifi physiolog biochem experi molecular biolog experi enterotoxin gene identifi pcr ota detect lc msms studi found isol aureus sea gene encod enterotoxin ota detect sampl maximum amount detect gkg result studi indic fail guarante cold chain presenc aureus enterotoxin gene milk present risk food safeti furthermor high detect rate level ota milk suggest ota hidden risk co occurr aureus ota milk food safeti concern need control occurr two biohazard milk
|
D013203;D009793
|
T131;T047;T109
|
36,287,985
|
smp scorpion venom peptid exhibit potent antitumor effect hepatoma hepg cell via multi mechan vivo vitro scorpion venom deriv peptid becom promis anticanc agent due cytotox tumor cell via multipl mechan suppress effect cation antimicrobi peptid smp deriv venom scorpio maurus palmatus prolifer hepatoma cell line hepg report earlier howev mode action hepg hepatoma cell remain unclear current research smp discov suppress viabil hepg cell minor effect normal lo cell moreov endocytosi pore format demonstr involv uptak smp hepg cell subsequ interact mitochondri membran caus decreas potenti cytoskeleton reorgan ros accumul mitochondri dysfunct alter apoptosi autophagi relat signal pathway protect activ smp hepg xenograft mice model also demonstr therefor data suggest antitumor effect smp close relat induct cell apoptosi cycl arrest autophagi via cell membran disrupt mitochondri dysfunct suggest potenti altern hepatocellular carcinoma treatment
|
D006528;D012604;D008113;D000970
|
T121;T123;T116;T109;T131;T191
|
36,287,984
|
compar venom proteom iranian macrovipera lebetina cernovi cypriot macrovipera lebetina lebetina giant viper envenom macrovipera lebetina subspeci caus sever life threaten difficulti peopl live north africa middl east better understand pathophysiolog envenom improv patient manag knowledg venom compon subspeci essenti venom proteom macrovipera lebetina lebetina cyprus macrovipera lebetina cernovi iran character use rp hplc separ crude venom protein sds page fraction protein lc msms peptid obtain gel tryptic digest protein band moreov also use high resolut shot gun proteom gain reliabl identif whole venom proteom subject direct solut digest lc hr msms data reveal venom consist least protein famili snake venom zn depend metalloproteas svmp serin proteas disintegrin phospholipas c type lectin like l amino acid oxidas togeth account venom protein content although two viper venom share most similar protein class relat occurr toxin differ snake subspeci instanc p class svmp toxin found abund p iii class venom l cernovi compar l lebetina give hint potent myonecrot effect minor system hemorrhag follow envenom l cernovi l lebetina moreov singl shot proteom also reveal mani protein low abund amp lt within venom aminopeptidas hyaluronidas glutaminyl peptid cyclotransferas cystatin phospholipas b vascular endotheli growth factor studi extend depth understand venom complex lebetina subspeci particular regard toxin famili associ envenom pathogenesi hard detect protein class express trace amount
|
D040901;D017819
|
T014;T091
|
36,287,983
|
microcystin lr primari liver cancer overview cyanobacteri bloom produc eutroph water bodi becom serious environment issu around world cellular lyse algaecid treatment microcystin mcs regard frequent encount cyanobacteri toxin fresh water releas water among variant mcs mc lr wide studi due sever hepatotox sinc various studi identifi import role mc lr origin progress primari liver cancer plcs although review focus therefor review aim summar major achiev shortcom observ past year base avail literatur mechan mc lr induc promot plcs elucid review review aim enhanc understand role mc lr play plcs provid ration approach futur applic
|
D006540;D008113
|
T131;T191
|
36,287,982
|
vitro effect enniatin steroidogenesi prolifer bovin granulosa cell emerg fusarium mycotoxin enniatin enn focus new research well document exist various cereal grain product research find indic reproduct disord may caus exposur fusarium mycotoxin littl work evalu enn reproduct function therefor determin effect enna prolifer steroidogenesi granulosa cell gc experi conduct use bovin gc cultur vitro enna inhibit p amp lt hormon induc gc progesteron estradiol product inhibitori effect enna estradiol product pronounc small larg follicl gc larg follicl gc enna effect p amp gt wherea enna inhibit gc prolifer small follicl gc enna dramat decreas p amp lt gc prolifer use cell number data ic enna estim follicl size conclud enna direct inhibit ovarian function cattl decreas prolifer steroid product gc
|
D005670;D009183
|
T131;T004;T109
|
36,287,981
|
nanobodi nanoluciferas fusion protein enabl immunoassay ochratoxin coffe enhanc specif sensit ochratoxin ota one best known mycotoxin caus problem concern food safeti potenti toxic effect human anim crucial develop simpl sensit method detect ota herein nanoluciferas nanobodi fusion protein nb nluc retain antibodi recognit enzymat activ first prepar appli bifunct tracer construct one step bioluminesc enzym link immunosorb assay bleia ota coffe sampl basi nb nluc bleia complet one step incub detect substrat replac tetramethylbenzidin tmb nluc assay reagent furimazin optim experiment condit propos one step bleia achiev detect limit ngml ic within h moreov bleia method show good repeat accuraci spike recoveri experi recoveri relat standard deviat rsds respect particular bleia display superior perform fewer oper rapid sensit detect compar nb base enzym link immunosorb assay therefor propos one step bleia great potenti sensit accur screen ota food sampl
|
D009793;D009183
|
T131;T109
|
36,287,980
|
investig toxic compound yield staphylococci vero cell bacteri secondari metabolit play major role allevi diseas howev cytotox metabolit ignor metabolit could detriment human cell three staphylococci strain staphylococcus aureus staphylococcus epidermidi staphylococcus saprophyticus use experi strain well known caus hospit communiti acquir infect secondari metabolit aureus isol milk cow clinic featur mastiti swollen udder product wateri clot milk saprophyticus atcc epidermidi atcc expos minim medium screen use gas chromatographi high resolut time flight mass spectrometri gc hrtof ms identifi nuclear magnet reson nmr epidermidi two compound isol oleamid methyl palmit three aureus includ fluoranthen methyl phenyl h pyrrol cyclo l leu l propyl saprophyticus yield succin acid hexantriol veratramin methyl pentyl amin secondari metabolit test cytotox use vero cell line fluoranthen exhibit toxic lc mgml vero cell metabolit methyl palmit least toxic metabolit result impli none compound except fluoranthen pose danger human cell
|
D013210;D013203
|
T047;T007
|
36,287,979
|
clostridium botulinum c toxin select deliveri cargo dendrit cell macrophag protein toxin cbot clostridium botulinum mono adp ribosyltransferas select intox monocyt deriv cell macrophag osteoclast dendrit cell dcs cytosol modif rho b c investig applic cbot well non toxic variant cboteq transport select deliveri cargo molecul macrophag dcs cbot cboteq facilit uptak egfp earli endosom human monocyt deriv macrophag reveal stimul emiss deplet sted super resolut microscopi fusion cargo model peptid egfp neither affect cell type select enhanc uptak human macrophag ex vivo compar lymphocyt cytosol releas cbot moreov cell fraction demonstr cbot cboteq strong enhanc cytosol releas function egfp subsequ modular system creat basi cboteq coval linkag cargo via thiol maleimid click chemistri function system proven load small molecul fluorophor establish report enzym investig cellular uptak cytosol releas cargo taken togeth non toxic cboteq promis candid cell type select deliveri small molecul peptid protein cytosol macrophag dcs
|
D001905;D003014
|
T121;T007;T116;T131
|
36,287,978
|
high sensit fluoresc screen print electrod electrochemiluminesc immunosensor ricin detect base cdsezn qds dual signal sensit dual readout immunosensor fluoresc electrochemiluminesc ecl detect ricin establish combin streptavidin biotin signal amplif system cdsezn quantum dot fine fluoresc ecl properti use dual signal function probe sandwich immunocomplex optimum experiment condit dual signal intens increas signific rise ricin concentr fluoresc intens senor exhibit good liner relationship toward ricin concentr ngml limit detect lod pgml take ecl detect signal sensor show linear relationship ricin concentr rang ngml ngml lod pgml construct sensor high sensit success appli detect ricin complex matric satisfactori recoveri propos immunosensor model extend analysi detect other target protein
|
D019187;D012276;D015374;D018036;D045663
|
T116;T075;T073;T131;T197;T059
|
36,287,977
|
mechan action peptid toxin target human rodent acid sens ion channel relev vivo analges effect acid sens ion channel asic voltag independ h gate cation channel larg express nervous system rodent human least six isoform asica b b associ homotrim heterotrim form function channel high ph depend gate properti review provid updat pharmacolog profil anim peptid toxin target asic includ pctx tarantula relat spider toxin apetx apetx like peptid sea anemon mambalgin snake well dimer protein snake toxin mittx instrument understand structur ph depend gate rodent human clone asic studi physiolog patholog role nativ asic vitro vivo asic express along pain pathway pharmacolog data clear support role channel pain asic target peptid toxin interfer asic gate complex ph depend mechan sometim lead opposit effect howev dual ph depend effect asic inhibit toxin pctx mambalgin apetx fulli compat even support analges effect vivo central peripher nervous system well potenti effect human
|
D062565;D013111
|
T123;T116;T131
|
36,287,976
|
botulinum neurotoxin type direct affect sebocyt modul oleic acid induc lipogenesi excess sebum seborrhea result oili skin associ larg pore size acn studi healthi seborrh volunt report intraderm inject commerci prepar botulinum neurotoxin type bonta onabotulinumtoxina abobotulinumtoxina incobotulinumtoxina reduc sebum product thus skin oili pore size mechan effect fulli elucid howev sever theori involv direct indirect effect bonta neuron andor dermal cell eg sebocyt propos present studi evalu direct effect nativ research grade bonta complex commerci prepar bonta onabota bonta variant sebocyt lipogenesi use vitro sebocyt cell model show picomolar concentr bonta bonta complex half maxim effect concentr ec pm bonta kda ec pm modul sebocyt lipogenesi reduc oleic acid induc sebocyt differenti lipogenesi holocrin like secret compar studi bind domain bonta lack enzymat activ show effect independ enzymat activ bonta like occur via sebocyt cell surfac receptor eg fibroblast growth factor receptor overal result shed light potenti mechan action rational use bonta treatment sebum relat condit
|
D019274
|
T129;T121;T116;T109;T131
|
36,287,975
|
efficaci addit mitig aflatoxin anim feed systemat review network meta analysi contamin anim feed aflatoxin ongo grow serious issu particular livestock farmer tropic subtrop region exposur anim aflatoxin contamin diet impair feed effici increas suscept diseas result mortal feed wast increas product cost also excret milk thus pose signific human health risk systemat review network meta analysi aim compar identifi effect intervent allevi negat impact aflatoxin import livestock sector poultri product elig studi efficaci feed addit mitig toxic effect aflatoxin poultri retriev differ databas addit classifi three categori base mode action composit organ binder inorgan binder antioxid moreov alanin transaminas alt liver enzym primari indic supplement aflatoxin contamin feed differ categori addit signific reduc serum alt level p amp lt compar bird fed contamin diet inorgan binder p score rank effici term counteract toxic effect aflatoxin follow antioxid p score organ binder p score find signific import farmer veterinarian anim nutrit compani decid type addit use mitig exposur aflatoxin thus improv food secur livelihood smallhold farmer develop countri
|
D000348
|
T131;T109
|
36,287,974
|
program aptam screen character rapid detect conotoxin mi conotoxin ctxs varieti mix polypeptid toxin among conotoxin mi ctx mi toxic serious toxic symptom lack counteract drug cumbersom detect process made ctx mi hidden danger human one obstacl resolv problem absenc specif recognit element aptam shown great advantag field molecul detect drug develop etc studi screen character aptam ctx mi program process mbmi c isol aptam show great affin affin constant kd form antiparallel g quadruplet gq structur specif recognit ctx mi addit aptasensor base biolay interferometri bli platform develop display high precis specif repeat limit detect lod aptasensor provid potenti tool rapid detect ctx mi min aptam develop enrich detoxif biolog studi ctx mi addit program process applic screen character aptam ctxs
|
D052157;D020916
|
T123;T131;T116;T114
|
36,287,973
|
variabl microcystin lr standard avail seven commerci vendor microcystin mcs larg group heptapeptid cyanobacteri toxin common produc harm algal bloom hab associ advers health effect wildlif livestock pet human mc chemic standard extract cyanobacteria biomass rather produc synthet use water assess method toxicolog studi mc standard general suppli less mg quantiti verif mass accomplish analyt chemistri method use certifi refer specif mc comparison analyt quantif mcs environment sampl toxicolog studi use accur dose test chemic administ experiment anim reli avail accuraci chemic standard check accuraci puriti avail standard seven individu microcystin lr mclr standard purchas separ commerci vendor analyz determin actual mass suppli identifi presenc potenti contamin determin effect vari toxin mass toxicolog studi mclr standard administ cd mice dose base mass purchas singl gkg intraperiton inject measur mass purchas vari vendor label mass two seven mclr standard contamin includ trifluoroacet acid tfa identifi four seven sampl compar vivo hepatotox vendor sampl close reflect actual amount mclr present standard demonstr toxicolog impact vari cyanotoxin mass
|
D052998;D000087522
|
T123;T116;T131
|
36,287,972
|
quantit proteom analysi zearalenon induc intestin damag wean piglet zearalenon zen also known f toxin common contamin cereal crop livestock product experi aim reveal chang proteom zen induc intestin damag wean piglet tandem mass spectrometri tag sixteen wean piglet either receiv basal diet basal diet supplement mgkg zen studi result show serum level zen zearalenol zearalenol increas wean piglet expos zen p amp lt zearalenon exposur reduc appar nutrient digest increas intestin permeabl caus intestin damag wean piglet meanwhil total differenti protein dep identifi control zen group regul dep regul dep fc amp gt amp lt p amp lt gene ontolog analysi reveal dep main involv substanc transport metabol gene express inflammatori oxid stress kyoto encyclopedia gene genom analysi reveal dep signific enrich signal pathway p amp lt relat inflamm amino acid metabol studi provid valuabl clue elucid possibl mechan zen induc intestin injuri
|
D015025
|
T131;T109
|
36,287,971
|
botulinum neurotoxin beyond neuron interplay glial cell recent year numer studi highlight signific use botulinum neurotoxin bont human therapi various motor autonom disord therapeut action exert select cleavag specif site snare protein complex play key role vesicular neuroexocytosi respons neural transmiss primari target bont action peripher neuromuscular junction nmj block cholinerg neuron releas acetylcholin ach interfer neural transmiss great deal experiment evid demonstr bont also effect block releas neurotransmitt neuromodul glutam substanc p cgrp interfer function glial cell peripher central level purpos review provid updat avail experiment data anim model suggest confirm direct interact bont glial cell data collect appear evid mechan yet fulli understood bont block activ spinal glial cell subsequ releas pro inflammatori factor bont also abl promot peripher regener process nerv injuri stimul prolifer schwann cell data discuss consider possibl therapeut implic use bont patholog condit contribut glial cell activ fundament peripher central neuropathi
|
D001905;D010523
|
T121;T047;T116;T131
|
36,287,970
|
botulinum toxin inhibit itch two decad report anti prurit effect botulinum neurotoxin bont still approv product anti itch indic bont clinic case report still focus label use bont various itchi condit random clinic trial conduct controversi result benefici effect bont itch main base case studi case seri studi valuabl present potenti applic bont chronic prurit condit due natur studi categor provid lower level evid lower grade recommend obtain approv anti prurit indic bont higher level evid requir achiev conduct larg scale well design studi proper control group establish care reliabl primari secondari outcom addit clinic evid present mechan base antiprurit action bont potenti strengthen acceler facilit current effort toward invest acceler field toward potenti approv bont itchi condit review therefor aim provid state art mechan under anti itch effect bont basic studi resembl various clinic condit itch hallmark evid neuron glial immun modulatori action bont reduc transmiss itch present futur potenti direct outlin
|
D001905
|
T121;T116;T131
|
36,287,969
|
aflatoxin contamin maiz groundnut sorghum grown burkina faso mali niger aflatoxin exposur assess aflatoxin contamin stapl crop aspergillus flavus close relat fungi common across sahel region africa aflatoxin maiz groundnut sorghum collect harvest farmer store within two week harvest burkina faso mali niger quantifi thereaft aflatoxin exposur valu assess use per capita consumpt rate crop mean aflatoxin concentr maiz high gkg mali burkina faso niger respect estim probabl daili intak pdi aflatoxin maiz rang ngkg bwday mali burkina faso niger respect similar mean aflatoxin concentr sorghum high gkg mali niger respect estim pdi groundnut mean aflatoxin concentr gkg mali burkina faso niger respect aflatoxin exposur valu high estim liver cancer case personsyear mali burkina faso niger respect sever sampl extrem unsaf exceed manyfold regulatori level divers countri time urgent attent need across sahel integr aflatoxin manag public health protect food nutrit secur access trade opportun
|
D000348;D045868
|
T131;T002;T109
|
36,287,968
|
mycotoxin product relationship microbi divers mycotoxin pyrus bretschneideri rehd cv huangguan pear mycotoxin generat seri fungal pathogen postharvest fruit result serious health threat consum great econom loss fruit storag industri microbi differ rotten healthi fruit storag relationship mycotoxin product fulli studi studi differ microbi divers rotten healthi fruit day storag ambient temperatur investig use high throughput sequenc technolog huangguan pear pyrus bretschneideri rehd cv huangguan harvest five differ produc region hebei provinc china bacteri genus gluconobact much abund rotten fruit healthi fruit addit komagataeibact acetobact also relat higher abund rotten fruit contrast bacteri genera pantoea alistip muribaculacea lactobacillus ruminococcaceaeucg found abund healthi fruit fungal genera includ botryosphaeria colletotrichum valsa alternaria rosellinia fusarium trichothecium found abund rotten fruit result princip coordin analysi pcoa show signific differ microbi divers differ region pat patulin detect rotten fruit sampl tenuazon acid tea alternariol aoh alternariolmonomethyl ether ame detect sampl collect one region weixian canon correl analysi cca pearson correl analysi show abund alistip pantoea negat correl content pat suggest bacteri genera alistip pantoea potenti reduc mycotoxin product huangguan pear
|
D031989;D009183;D010365
|
T168;T131;T002;T109
|
36,287,967
|
corynebacterium sp td mediat toxic tridecanon helicoverpa armigera cotton bollworm helicoverpa armigera lepidopteran noctuid pest global distribut wide rang host plant harm cotton tomato tobacco corn well crop h armigera larva damag flower bud flower fruit tomato caus serious loss tomato product tomato use allelochem tridecanon defend damag far report whether adapt h armigera tridecanon relat symbiot microorgan studi found corynebacterium sp td symbiot bacteria h armigera mediat toxic tridecanon h armigera corynebacterium sp td identifi rdna gene sequenc analysi screen use basal salt medium contain uniqu carbon sourc tridecanon corynebacterium sp td confirm distribut gut h armigera quantit pcr qpcr fluoresc situ hybrid fish surviv rate h armigera increas tridecanon stress inocul corynebacterium sp td degrad effect corynebacterium sp td tridecanon verifi ultra high perform liquid chromatographi uplc studi first report isol gut bacteria degrad tridecanon import agricultur pest h armigera confirm bacteri involv host adapt tridecanon provid new insight adapt mechan agricultur pest host plant
|
D009036
|
T204
|
36,287,966
|
nicotin acetylcholin receptor novel target apetx like toxin sea anemon heteracti magnifica nicotin acetylcholin receptor nachr prototyp ligand gate ion channel provid cholinerg signal modul various venom toxin drug addit neurotransmitt four apetx like toxin includ two new toxin name hmg b metox hmg b isol sea anemon heteracti magnifica character novel nachr ligand acid sens ion channel asic modul peptid compet radiolabel bungarotoxin bind torpedo californica muscl type human nachr hmg b potenti acetylcholin elicit current human receptor express xenopus laevi oocyt moreov multigen famili code apetx like peptid librari h magnifica describ silico surfac electrostat potenti novel peptid analyz explain ident peptid isoform h magnifica h crispa rrna coi analysi perform shown sea anemon previous identifi morpholog h crispa belong speci h magnifica
|
D012615;D011978;D014118
|
T123;T116;T192;T131;T204
|
36,287,965
|
evalu novel synthet peptid deriv cytolyt mycotoxin candidalysin import neuroinflamm neurolog becom increas appar addit neuroinflammatori diseas multipl sclerosi role neuroinflamm identifi mani non inflammatori neurolog disord stroke epilepsi cancer immun respons within brain involv presenc cns resid cell main glial cell microglia cns resid macrophag evalu peptid ca map bioinspir c albican immatur cytolyt toxin candidalysin develop less hemolyt peptid anti neuroinflammatori antibacteri cytotox activ tumor cell silico vitro studi perform various concentr ca map exhibit low hemolyt activ lower concentr cytotox mrc bv cell ca map show activ acinetobact baumannii escherichia coli atcc e coli kpc klebsiella pneumonia atcc pseudomona aeruginosa staphylococcus aureus atcc furthermor ca map exhibit anti neuroinflammatori activ bv microglia model inhibit nitrat product ca map present cytotox activ tumor cell line nci h ic ca map demonstr result qualifi evalu next step promot control infect provid altern antitumor therapi
|
D004926;D009183
|
T131;T007;T109
|
36,287,964
|
possibl reaction mechan involv degrad patulin heat assist cystein high acid condit patulin pat one mycotoxin usual contamin appl juic easili detoxifi cystein cys room temperatur due high acid condit base michael addit reaction howev could effect degrad heat treatment c min presenc cystein studi total eight degrad product dp h character identifi via liquid chromatographi quadrupol time flight mass spectrometri lc q tof ms negat ion mode structur formula propos base accur mass data fragment pattern pat degrad product obtain msms analysi meanwhil possibl reaction mechan involv degrad pat establish explain first time accord relat structur toxic pat could deduc toxic effect pat degrad product potenti much less pat self
|
D010365;D027845
|
T131;T168;T002;T109
|
36,287,963
|
earli advers reaction snake antivenom poison center data analysi antivenom essenti treatment snake envenom howev earli advers reaction ear major limit use perform retrospect cross section studi use ramathibodi poison center data januari decemb clarifi incid sever ear follow differ f ab antivenom among envenom patient receiv antivenom therapi total dose most green pit viper antivenom overal ear incid rate respect ear rate follow type antivenom amp gt except russel viper antivenom sever reaction rate malayan pit viper bite caus high incid ear highest ear rate fifti two case develop anaphylaxi ear occur within h treatment initi death attribut ear durat administr signific differ dose antivenom induc ear conclus type everi dose antivenom infus min prepar resuscit equip continu clinic observ crucial least h administr prompt treatment provid ear occur
|
D011042;D012909;D017840
|
T014;T131;T037
|
36,287,962
|
ochratoxin dri cure ham ota produc fungi preval detect method biocontrol strategi review tradit dri cure ham easili contamin toxigen fungi ferment ripen stage detect posit rate ochratoxin ota highest among mycotoxin detect tradit dri cure ham indic ota ham potenti safeti hazard human health review address mycotoxin produc fungal speci toxigen condit caus ota contamin worldwid preval ota contamin dri cure ham detect method appli ota analysi addit studi introduc method prevent control ota tradit dri cure ham growth common mycotoxin produc fungi accumul mycotoxin dri cure ham control microbi starter review provid import theoret foundat research control ota tradit dri cure ham
|
D000080305;D010407;D009793;D009183
|
T168;T004;T131;T109
|
36,287,961
|
quantit proteom analysi zearalenon exposur uterin develop wean gilt aim studi explor effect zearalenon zea exposur uterin develop wean gilt quantit proteom analysi tandem mass spectrometri tag tmt total healthi wean gilt random divid control basal diet zea treatment group basal diet supplement mgkg zea result show vulva size uterin develop index increas p amp lt wherea serum follicl stimul hormon lutein hormon gonadotropin releas hormon decreas gilt fed zea diet p amp lt zea zearalenol zol zearalenol zol detect uteri gilt fed mgkg zea diet p amp lt relat protein express level creatin kinas type ckm atriopeptidas mme myeloperoxidas mpo regul p amp lt wherea aldehyd dehydrogenas famili member aldha secretogranin chgb surp g patch domain contain sugp regul p amp lt zea group western blot indic proteom data depend addit function differenti express protein dep main involv cellular process biolog regul metabol process biolog process categori import signal pathway chang zea group extracellular matrix ecm receptor interact focal adhes phosphoinositid kinas protein kinas b pik akt signal pathway p amp lt studi shed new light molecular mechan zea uterin develop gilt
|
D015025
|
T131;T109
|
36,287,960
|
robust sensit spectrophotometr assay enzymat activ bacteri adenyl cyclas toxin various bacteri pathogen produc toxin target cyclic nucleotid monophosph cnmps signal pathway order facilit host colon among sever exhibit potent nucleotidyl cyclas activ activ eukaryot factor adenyl cyclas ac toxin cyaa bordetella pertussi edema factor ef bacillus anthraci character toxin frequent requir accur measur enzymat activ vitro particular deciph structur function relationship protein engin site direct mutagenesi describ simpl robust vitro assay ac activ base spectrophotometr detect cyclic amp camp chromatograph separ aluminum oxid assay accur detect fmol amount b pertussi cyaa even use complex media cell extract relat advantag disadvantag assay comparison current avail method briefli discuss
|
D001886;D000242
|
T121;T123;T007;T114
|
36,287,959
|
multipl mycotoxin contamin medicin plant frequent sold free state provinc south africa detect use uplc esi msms medicin plant import south african tradit healthcar system growth consumpt led increas trade muthi shop street vendor medicin plant prone contamin fungi mycotoxin studi investig multipl mycotoxin contamin use ultra high pressur liquid chromatographi tandem mass spectrometri uplc esi msms simultan detect aflatoxin b afb deoxynivalenol fumonisin fb fb fb nivalenol niv ochratoxin ota zearalenon zen frequent sold medicin plant medicin plant sampl n purchas analyz presenc eight mycotoxin niv detect sampl analyz ten thirti four sampl test posit mycotoxin afb ota fb fb fb zen mean concentr level rang afb gkg ota gkg fb gkg fb gkg fb gkg zen gkg multipl mycotoxin contamin observ posit sampl fumonisin concentr afb report studi permiss limit afb gkg fumonisin concentr exceed limit set raw maiz grain gkg fb fb zen ota regul south africa find indic preval mycotoxin contamin frequent trade medicin plant pose health risk consum therefor need routin monitor multipl mycotoxin contamin human exposur assess use biomark analysi establish regul standard
|
D009183;D037341;D010946;D015025
|
T131;T002;T109
|
36,287,958
|
mitig potenti novel lactobacillus plantarum tistr aflatoxin associ oxid stress histopatholog alter liver kidney broiler chick entir growth period aflatoxin secondari metabolit produc aspergillus flavus aspergillus parasiticus sever patholog effect health human anim present studi design investig toxicopatholog chang induc aflatoxin mitig potenti lactobacillus plantarum broiler bird one hundr eighti broiler chick one day age procur local market chick equal divid six group thirti bird group bird treat aflatoxin gkg lactobacillus plantarum cfukg feed differ combin first group kept control basal diet provid bird bd second group af first level aflatoxin gkg fed bird third group af second level aflatoxin gkg fed bird fourth group aflp lactobacillus plantarum given first level aflatoxin fifth group aflp lactobacillus plantarum given second level aflatoxin th group bdlp lactobacillus plantarum alon fed chick experiment studi continu day bird slaughter day differ paramet assess paramet studi gain bodi weight organ weight along histopatholog hematolog biochem paramet residu aflatoxin liver kidney lactobacillus plantarum improv bodi weight gain restor relat organ weight hepat renal biomark return normal concentr serum protein restor combin group aflp partial amelior observ aflp group red blood cell white blood cell hemoglobin centrat pack cell volum becam normal aflp group partial amelior observ aflp group lp also reduc concentr aflatoxin residu liver kidney improv tac concentr result studi elucid mitig potenti lactobacillus plantarum serum biochem histopatholog hematolog toxicopatholog chang induc aflatoxin chick
|
D000348;D048191
|
T131;T007;T109
|
36,287,957
|
shotgun metagenom sequenc assess cyanobacteri communiti composit follow coagul cyanobacteri bloom excess prolifer cyanobacteria surfac water widespread problem worldwid lead contamin drink water sourc short long term solut manag cyanobacteri bloom need drink water suppli goal research investig cyanobacteria communiti composit use shotgun metagenom short term situ mesocosm experi two lake follow coagul ferric sulfat fe option sourc water treatment among nutrient parament dissolv nitrogen relat microcysti missisquoi bay petit lac st franoi presenc synechococcus relat total nitrogen dissolv nitrogen dissolv organ carbon dissolv phosphorus result shotgun metagenom sequenc show dolichospermum microcysti domin genera mesocosm begin sampl period missisquoi bay petit lac st franoi respect potenti toxigen genera microcysti correl intracellular microcystin concentr princip compon analysi show chang cyanobacteri composit genus level mesocosm two day vari across studi site sampl time cyanobacteri communiti rich divers chang signific coagul fe mesocosm either site use fe onsit sourc water treatment consid impact cyanobacteri communiti structur reduct toxin concentr
|
D060766;D000458;D046931
|
T007;T167
|
36,287,956
|
aflatoxin cereal cereal base product occurr toxic impact human health detoxif manag strategi cereal cereal base product primari sourc nutrit across world howev contamin food aflatoxin af secondari metabolit produc sever fungal speci rais serious concern af generat innat substrat influenc sever paramet includ substrat type fungus speci moistur content miner humid temperatur physic injuri kernel consumpt af contamin cereal cereal base product lead acut chronic health issu relat physic mental matur reproduct nervous system therefor precis detect method detoxif manag strategi af cereal cereal base product crucial food safeti well consum health henc review provid brief overview occurr chemic characterist biosynthet process health hazard detect techniqu af along focus detoxif manag strategi could implement food safeti secur
|
D000348
|
T131;T109
|
36,287,955
|
realiz herit risk assess inherit pattern earia vittella lepidoptera noctuida resist dipel bacillus thuringiensi kurstaki earia vittella fabricius potenti cotton okra pest south asia realiz herit risk assess inherit mode bacillus thuringiensi kurstaki btk resist determin dipel select dipel sel e vittella dipel sel strain fold rise dipel resist nine generat compar laboratori refer strain lab pk overlap fiduci limit median lethal concentr lcs f dipel sel lab pk f dipel sel lab pk suggest lack sex linkag autosom dipel resist domin dlc valu f f indic incomplet domin resist dipel backcross f lab pk reveal polygen respons resist dipel realiz herit estim h resist dipel select mortal generat requir tenfold increas lc dipel h respect constant slope slope valu constant h generat need increas tenfold lc dipel dipel sel e vittella conclud dipel sel e vittella autosom incomplet domin polygen natur resist h suggest high proport phenotyp variat dipel resist e vittella herit genet variat present result support creation effect suitabl resist manag plan better control e vittella
|
D001413;D009036;D007306
|
T131;T007;T204
|
36,287,954
|
new knowledg distribut abund toxic microalg speci relat toxin northwestern black sea numer potenti toxic plankton speci common occur black sea phycotoxin report howev taxonomi phycotoxin profil distribut harm microalga basin still understudi integr microscop light microscopi molecular rrna gene metabarcod qpcr approach complement toxin analysi appli station northwestern part black sea better taxonom coverag toxin profil natur popul combin dataset includ potenti toxic speci dinophysi acuminata dinophysi acuta gonyaulax spinifera karlodinium veneficum detect station parallel pectenotoxin ptx major toxin regist sampl yessotoxin present sampl point ptx ptx well ytx variant record first time basin posit correl found cell abund dinophysi acuta pectenotoxin lingulodinium polyedra protoceratium reticulatum yessotoxin toxic microalga toxin variant abund spatial distribut associ environment paramet despit low level identifi phycotoxin low oral toxic chronic toxic exposur could repres ecosystem human health hazard
|
D058086;D004141
|
T204
|
36,287,953
|
nitrogen limit intens toxic cyanobacteria bloom lake within two visit park usa lake central park prospect park lake lake central park lcp prospect park lake ppl new york citi nyc usa lake within two visit park usa five year nearshor sampl system reveal extrem elev level cyanobacteria toxin microcystin microcystin level averag g l chlorophyl cyanobacteri cyano chla popul averag g cyano chla l lake display elev level orthophosph dip relat dissolv inorgan nitrogen din summer month din dip ratio amp lt nutrient addit dilut experi reveal n consist limit cyanobacteri popul green alga rare nutrient limit experiment addit public drink water rich p lesser extent n lake water signific enhanc cyanobacteri growth rate experi n addit also yield growth enhanc collect studi demonstr extrem microcystin level bloom high traffick lake repres potenti human anim health threat supplement artifici lake public drink water maintain water level summer may promot intens n limit bloom
|
D060766;D000458
|
T007;T167
|
36,287,952
|
construct character applic nonpathogen virus like model sar cov nucleocapsid protein phage display outbreak spread covid deep investig sar cov urgent direct usag virus scientif research could provid reliabl result authent howev strict constrain unrealist due high pathogen infecti consid biosafeti differ system technolog employ immunolog biomed studi studi phage display technolog use construct nonpathogen model covid research nucleocapsid protein sar cov fuse phage capsid p protein express phage valid success express potenti standard qpcr quantif affin antibodi confirm may show possibl use nonpathogen bacteriophag replac pathogen virus scientif research concern sar cov addit model use develop system classif identif differ sampl use atr ftir may provid idea develop evalu virus monitor equip futur
|
D000086382;D014780
|
T047;T005;T067
|
36,287,951
|
possibl toxic mechan deoxynivalenol exposur intestin barrier damag dysbiosi gut microbiota lay hen deoxynivalenol one common mycotoxin cereal grain caus serious health threat poultri farm anim previous studi found decreas product perform lay hen report could exert signific toxic effect intestin barrier microbiota howev whether declin lay perform relat intestin barrier damag under mechan induc intestin function injuri remain larg unclear lay hen studi hy line brown lay hen week random divid mgkgbw bodi weight daili week morpholog duodenum express inflamm factor tight junction protein divers abund microbiota analyz differ level treat lay hen result demonstr mucos detach reduct villi number present differ treat group dose effect manner addit gene express pro inflammatori factor il il tnf anti inflammatori factor il increas decreas mgkgbw group respect level zo claudin express signific decreas mgkgbw group moreov alpha divers includ chao ace shannon indic reduc treat group phylum level firmicut actinobacteria bacteroidet proteobacteria spirochaet decreas increas mgkgbw group respect genus level relat abund clostridium lactobacillus mgkgbw group alkanindig spirochaeta mgkgbw signific decreas increas respect moreov signific correl express tight junction protein relat abund lactobacillus succinispira result indic exposur lay hen induc inflamm disrupt intestin tight junction suggest direct damag barrier function may close relat dysbiosi intestin microbiota
|
D000069196;D007410;D014255
|
T123;T007;T109;T131;T047;T001
|
36,287,950
|
applic non aflatoxigen aspergillus flavus biolog control aflatoxin contamin china biolog control applic competit non aflatoxigen aspergillus flavus flavus soil peanut growth practic method control aflatoxin contamin howev appropri materi need found reduc cost biocontrol product studi two year experi conduct field condit china use nativ non aflatoxigen strain explor effect three month storag high humid aflatoxin level remain low peanut field treat biocontrol agent three type substrat test biocontrol agent rice grain peanut meal peanut meal fertil peanut coat compar untreat field formul result reduct respect furthermor ratio non aflatoxigen flavus recov soil harvest treat field higher untreat field indic rice inoculum effect follow peanut meal fertil peanut coat mean aflatoxin content fresh harvest peanut untreat field gkg higher field treat kgha rice inoculum gkg moreov aflatoxin detect two plot treat kgha rice inoculum studi show nativ chines non aflatoxigen strain flavus pasp zy potenti reduc aflatoxin contamin peanut addit peanut meal use altern substrat replac tradit grain reduc cost biocontrol product
|
D000348;D012275
|
T131;T168;T002;T109
|
36,287,949
|
tardiv oromandibular dystonia induc trazodon clinic case manag perspect dental specialist tardiv oromandibular dystonia iatrogen drug induc movement form extrapyramid symptom associ primarili chronic consumpt dopamin receptor block agent tardiv symptom attribut select serotonin reuptak inhibitor antidepress far less preval
|
D004421;D014196;D020821
|
T184;T121;T109;T047;T048
|
36,287,948
|
time lag correl analysi shellfish toxic reveal predict link adjac area speci environment condit diarrhet shellfish poison dsp acut intox caus consumpt contamin shellfish common mani region world safeguard human health countri implement program focus surveil toxic phytoplankton abund shellfish toxic level effort complement deeper understand under phenomena work identifi pattern season shellfish toxic across portugues coast analys time lag correl toxic various potenti risk factor extend understand relat introduct tempor lag allow analysi time seri differ point time studi predict power test variabl studi confirm previous find toxic season pattern portugues coast provid quantit data relat shellfish toxic geograph locat shellfish speci toxic phytoplankton abund environment condit furthermor multipl pair area shellfish speci identifi correl high enough allow predict analysi result repres first step toward understand dynam dsp toxic portugues shellfish produc area tempor spatial variabl toward develop shellfish safeti forecast system
|
D057096
|
T037
|
36,287,947
|
red yeast sporidiobolus pararoseus use novel feed addit mycotoxin binder broiler chicken mycotoxin contamin feed may negat affect broiler chicken health henc sustain approach achiev mycotoxin elimin necessari studi aim evalu efficaci red yeast sporidiobolus pararoseus ry novel mycotoxin binder broiler total one week old male broiler chick random assign treatment factori design dietari treatment includ three level mycotoxin contamin diet g kg mycotoxin mt g kg mt g kg mt four level mycotoxin binder g kg commerci binder g kg ry experiment diet contamin aflatoxin b zearalenon ochratoxin toxin deoxynivalenol basal diet furthermor paramet includ feed intak bodi weight mortal rate record week basi feed day blood organ sampl collect random determin blood biochemistri relat organ weight gut health result indic mycotoxin contamin diet reduc averag daili weight gain adg villus height vh villus height per crypt depth ratio vh cd intestin well popul lactobacillus sp bifidobacterium sp cecal p amp lt wherea increas mycotoxin concentr blood sampl apoptosi cell tunel posit liver tissu p amp lt broiler chicken contrast ry supplement diet better adg valu lower chicken mortal rate p amp lt moreov combin posit impact relat organ weight blood paramet bacteria popul intestin morpholog patholog chang hepatocyt p amp lt conclus ry supplement effect allevi toxic induc afb ota main could potenti appli novel feed addit broiler industri
|
D000821;D001688;D009183
|
T121;T123;T109;T168;T131
|
36,287,946
|
potenti biochem pesticid synthesi neofuranocoumarin inhibit prolifer spodoptera frugiperda cell activ mitochondri pathway furanocoumarin secondari metabolit plant consid natur insecticid fungicid prevent invas plant pathogen microorgan predat herbivor insect studi novel arylfuranocoumarin deriv design synthes condens esterif bromin wittig reaction result show excel photosensit activ thiophenylfuranocoumarin cell count kit detect could inhibit prolifer spodoptera frugiperda sf cell time concentr depend manner ultraviolet uv light min invert microscop reveal cell treat swell membran ruptur apoptot bodi appear flow cytometri detect could induc apoptosi sf cell increas level intracellular reactiv oxygen speci ros decreas mitochondri membran potenti block cell cycl arrest gm phase transmiss electron microscopi detect cell mitochondri crista damag matrix degrad mitochondri vacuol enzym activ detect reveal enzym activ apoptosi relat protein caspas caspas increas signific p amp lt final western blot analysi detect phosphoryl level akt bad express apoptosi inhibitor protein bcl xl inhibit cleav parp p increas cytochrom c releas mitochondria cytoplasm moreov uv irradi promot increas ros sf cell activ mitochondri apoptot signal transduct pathway final inhibit cell prolifer thus novel furanocoumarin exhibit potenti applic prospect biochem pesticid
|
D007306;D010575;D005659;D011564
|
T131;T121;T109
|
36,287,945
|
reason determin bont treatment discontinu patient live spastic year retrospect analysi present studi aim evalu reason determin bont discontinu patient stroke multipl sclerosi spinal cord injuri traumat brain injuri
|
D009465;D019274;D009103;D013119;D020521;D000070642
|
T129;T121;T116;T109;T131;T037;T039;T047
|
36,287,944
|
short term impact botulinum neurotoxin muscl morpholog gait children spastic cerebr palsi children spastic cerebr palsi scp often treat intramuscular botulinum neurotoxin type bont recent studi demonstr bont induc muscl atrophi variabl effect gait patholog group match control studi children scp compar chang muscl morpholog week post bont treatment n median age year gmfcs level iiiiii morpholog chang untreat control group n median age year gmfcs level iiiiii addit effect gait spastic assess treat children subgroup n respect bont treatment appli follow establish integr approach gastrocnemius semitendinosus volum echogen intens assess freehand ultrasound spastic quantifi electromyographi passiv muscl stretch differ veloc ankl knee kinemat evalu gait analysi medial gastrocnemius p semitendinosus muscl volum p reduc post bont untreat control group echogen intens chang spastic reduc ankl gait kinemat signific improv combin limit effect knee kinemat studi demonstr bont reduc spastic part improv patholog gait reduc muscl volum week post inject close post bont follow well consid treatment select advis bont applic scp
|
D019274;D002547;D009465
|
T039;T129;T121;T116;T109;T131;T019;T047
|
36,287,943
|
ultrasound guidanc improv effect neurotoxin inject patient cervic dystonia prospect partial blind clinic studi aim studi evalu efficaci ultrasound guidanc us treatment cervic dystonia cd botulinum neurotoxin type bont inject comparison anatom landmark al date us routin use mani center other deni use
|
D014103;D019274;D009465
|
T129;T184;T121;T116;T109;T131;T039;T048
|
36,287,942
|
cytokin chemokin retent profil covid patient chronic kidney diseas chronic kidney diseas ckd patient suscept infect compar general popul sar cov virus patholog character cytokin storm respons system inflamm typic covid diseas sinc ckd patient reduc renal clearanc decid investig whether accumul harm mediat covid diseas conduct retrospect studi covid hospit subject acut phase ill thirteen differ cytokin assess plasma collect upon hospit patient divid three group accord estim glomerular filtrat rate egfr amp lt n amp lt egfr amp lt n egfr amp gt mlmin n found tumor necrosi factor receptor ii interleukin leukemia inhibitori factor fas receptor chitinas like vascular endotheli growth factor show increas accumul negat correl egfr moreov non survivor patient impair kidney function signific elev level mediat conclus tendenc covid esrd patient accumul harm cytokin accumul seem associ mortal outcom may due reduc clearanc also increas biosynthesi sever case
|
D002688;D000086382;D051437;D051436
|
T047;T126;T116;T067
|
36,287,941
|
optim aflatoxin b lysin analysi public health exposur studi aflatoxin b potent human carcinogen produc sever speci aspergillus main found nut maiz exposur part africa latin america asia multipl sometim order magnitud toler daili level although human exposur aflatoxin estim analysi diet determin serum albumin aflatoxin adduct provid health relev exposur measur lack refer serum limit interlaboratori method valid data comparison studi synthet produc afb dialdehyd coval coupl serum albumin human serum synthet produc aflatoxin serum refer materi use conjunct isotop label intern standard evalu sampl digest method show use suffici pronas digest step critic ensur complet proteolyt digest occur within h increas digest temperatur c c also provid benefit overal analysi addit use dri blood spot volumetr absorpt microsampl vam investig show sampl store vam produc equival result serum sampl
|
D016604;D000348
|
T131;T196;T109
|
36,287,940
|
influenc season food type bacteri entero toxigen preval staphylococcus aureus staphylococcus aureus coagulas posit pathogen interest human health food safeti particular surviv wide environment temperatur rang c optimum c enterotoxin thermost increas risk potenti contamin varieti food product investig influenc season food type bacteri count presenc aureus enterotoxin analyz food sampl collect year period ordin logist regress show influenc season food type bacteri count regard bacteri count winter found season highest risk regard enterotoxin product highest risk found autumn specif octob risk contamin aureus greatest dairi product find may inform food epidemiologist foodborn ill prevent risk human health
|
D013211;D013203
|
T047;T007
|
36,287,939
|
effect combin compound probiot glycyrrhin acid allevi cytotox ipec j cell induc multi mycotoxin aflatoxin b afb deoxynivalenol zearalenon zea three preval mycotoxin whose contamin food feed sever worldwid problem order allevi toxic effect multi mycotoxin afb zea adz inflamm apoptosi swine jejun epitheli cell ipec j three speci probiot bacillus subtili saccharomyc cerevisia pseudomona lacti cfuml respect mix togeth make compound probiot cp combin gml glycyrrhin acid ga make bioactiv materi cga experi divid four group ie control adz cga adz cga group result show adz decreas cell viabil induc cytotox cga addit could allevi adz induc cytotox moreov mrna express il tnf nf b bcl caspas zo occludin claudin asct gene protein express tnf claudin signific upregul adz group mrna abund il tnf nf b caspas asct gene protein express tnf claudin signific downregul adz cga group addit protein express cox zo asct signific downregul adz group compar control group wherea cga co incub adz could increas protein express recov normal level studi indic cga could allevi cytotox apoptosi inflamm adz induc ipec j cell protect intestin cell integr adz damag
|
D009183;D015025;D014255;D019936
|
T131;T007;T123;T109
|
36,287,938
|
spla wobbl lipid bilay three posit involv hydrolysi process secret phospholipas splas peripher membran enzym hydrolyz phospholipid sn posit action spla associ work two activ site one interfac bind site ib need bind enzym membran surfac one catalyt site need hydrolyz substrat interplay site substrat protrud hydrolysi product releas catalyt site remain focus investig report bee venom pla two addit interfac bind mode enzym activ constant switch three differ orient mode bind one respons substrat uptak bilay find obtain independ use atom forc microscopi molecular dynam switch mode biolog signific mode step enzym move along membran product releas biolog milieu enzym desorpt bilay surfac
|
D054497;D001514
|
T123;T126;T116;T131
|
36,287,937
|
potassium bioaccess uncook cook plant food result static vitro digest methodolog hyperkalemia major concern chronic kidney diseas end stage renal diseas repres predictor hospit mortal prevent treat hyperkalemia dietari manag great clinic interest current grow use plant base diet caus increas concern potassium load renal patient aim studi assess bioaccess potassium veget concern aspect plant fruit flower root tuber leaf seed extent differ boil techniqu affect potassium content bioaccess plant base food bioaccess evalu vitro digest methodolog resembl human gastro intestin tract potassium content higher seed leav despit possibl defin common rule accord type organ name seed leaf fruit boil reduc potassium content veget exclud carrot zucchini cauliflow boil start cold water contribut greater reduct potassium content potato pea bean bioaccess vitro digest rang pea tomato regardless speci organ higher bioaccess found spinach chicori zucchini tomato kiwi cauliflow lower bioaccess pea potassium leaf result highest bioaccess digest whole potassium bioaccess fruit veget studi averag differ relat differ organ speci consid method boil reduc potassium content data indic effect potassium load plant base food may lower origin expect support clinic advic maintain wide use plant base food manag renal patient
|
D006947;D001937;D018551
|
T033;T168;T002
|
36,287,936
|
botulinum toxin drug potenti interest dentist introduct review introduct medic non cosmet treatment botulinum neurotoxin bont orofaci region focus current common best document safest indic interest dentist term dystonia sialorrhea condit recommend start suitabl gain better skill experi bont introduct also stress import correct diagnost base interdisciplinari cooper precis target inject measur treatment effect control oral health regard side effect
|
D019274;D012798;D020821;D004421
|
T129;T121;T184;T116;T109;T131;T033;T047;T048
|
36,287,935
|
effect flexor digitorum longus muscl anatom structur respons botulinum toxin treatment patient post stroke claw foot deform background purpos retrospect case control studi determin relationship control toe movement flexor halluci longus fhl flexor digitorum longus fdl muscl respons treatment botulinum toxin bont post stroke patient claw toe method subject stroke relat leg paralysisspast claw toe receiv multipl inject bont onabotulinumtoxin fhl fdl muscl investig relationship mode transmiss fhl fdl muscl tension toe mct treatment outcom use data patient receiv inject clinic record treatment outcom also dissect potenti variabl could determin treatment outcom result effect bont treatment signific alter fdl mct ci p analysi respons first bont inject show odd ratio fdl mct approxim time ci p tibial influenc fdl muscl toe better treatment outcom claw toe conclus anatom relat fdl muscl toe seem affect respons treatment bont post stroke patient claw toe
|
D037801;D019274;D005530
|
T129;T121;T116;T190;T109;T131;T020
|
36,287,934
|
effect compound mycotoxin detoxifi allevi aflatoxin b induc inflammatori respons intestin liver kidney broiler order allevi toxic effect aflatoxin b afb inflammatori respons intestin liver kidney broiler aflatoxin b degrad enzym montmorillonit compound probiot select combin make tripl action compound mycotoxin detoxifi cmd feed experi divid two stage earli feed stage day total one day old ross broiler random divid four group later feed stage day broiler age day assign four group group basal diet gkg afb group b basal diet gkg afb group c group plus gkg cmd group group b plus gkg cmd feed experi intestin liver kidney tissu broiler select investig molecular mechan cmd allevi tissu damag analys mrna abund western blot wb inflammatori factor well immunohistochem ihc stain intestin liver kidney tissu show afb aggrav inflammatori respons nf b tn signal pathway via tlr pattern receptor addit cmd signific inhibit inflammatori respons phylogenet investig show afb signific increas interleukin receptor associ kinas irak mitogen activ protein kinas mapk activ p amp lt restor normal level cmd addit indic cmd could allevi cell inflammatori damag induc afb
|
D016604;D009183
|
T131;T196;T109
|
36,287,933
|
character potenti threat cyanobacteri toxin lake victoria embay water treatment africa water need often support eutroph water bodi domin cyanobacteria pose health threat riparian popul cyanotoxin lake victoria except two embay lake murchison bay napoleon gulf cyanobacteri survey conduct character dynam cyanotoxin lake water water treatment plant forti six cyanobacteri taxa record fourteen consid potenti toxigen ie genera dolichospermum microcysti oscillatoria pseudanabaena raphidiopsi higher concentr rang g mc lr equiv l microcystin mc detect murchison bay compar napoleon gulf declin gradient inshor max g mc lr equiv l open lake murchison bay increas microcysti sp biovolum mc observ last two decad despit high cell densiti toxigen microcysti high mc concentr water treatment plant murchison bay effici remov cyanobacteri biomass intracellular dissolv mc lifetim guidelin valu exposur via drink water amp lt g mc lr equiv l thus potenti health threat stem consumpt untreat water recreat activ along shore lake embay mc concentr predict microcysti cell number regul environment factor solar radiat wind speed n direct turbid thus earli warn microscop count microcysti cell number propos better manag health risk toxigen cyanobacteria lake victoria
|
D060766;D046931;D000458;D018508
|
T007;T052;T167;T057
|
36,287,932
|
therapeut effect bee venom melittin skin infect caus streptococcus pyogen streptococcus pyogen pyogen bacteria caus almost primari skin infect human bee venom bv melittin mel multipl effect includ antibacteri anti inflammatori activ studi aim demonstr effect bacteri mous skin infect use pyogen dorsal skin tape strip pyogen topic appli bv mel topic appli lesion tissu stain hematoxylin eosin immunohistochem stain perform anti neutrophil pyogen infect skin reveal increas epiderm dermal layer reduc bv mel group find increas neutrophil mice infect pyogen bv mel mice show decreas express result suggest bv mel treatment could reduc inflammatori reaction help improv lesion induc pyogen skin infect studi provid addit assess potenti therapeut effect bv mel manag skin infect caus pyogen suggest could candid develop novel treatment altern streptococc skin infect
|
D001514;D017192
|
T123;T047;T116;T131
|
36,287,931
|
investig advers event associ bee venom pharmacopunctur patient hospit korean hospit retrospect chart review studi bee venom pharmacopunctur bvp bee venom isol venom sac bee inject acupoint muscl associ diseas howev histamin compon bee venom caus advers event therefor attent requir bvp use studi investig frequenc sever characterist patient develop bvp associ advers event medic record patient treat bvp kyung hee univers korean medicin hospit januari may review demograph characterist diseas relat characterist treatment relat characterist impress patient analyz studi amp gt inpati hospit neurolog disord mean age overal studi popul year women frequenc advers event mean age advers event group year women two patient experienc moder advers event common event everi patient recov natur sequela result show bvp relat safe therapeut method howev studi need determin frequenc advers event identifi causal baselin characterist advers event
|
D001514;D026881
|
T123;T091;T116;T131
|
36,287,930
|
nanobodi base immunoassay detect ustilaginoidin rice sampl ustilaginoidin class bis naphtho pyron mycotoxin produc pathogen villosiclava viren rice fals smut recent becom one devast diseas rice grow region worldwid research nanobodi phage display librari establish alpaca immun hemiustilaginoidin f hapten coupl bovin serum albumin bsa heterolog antigen select comb trypsin competit altern elut method perform nanobodi screen two nanobodi name nb b nb c select establish indirect competit enzym link immunosorb assay ic elisa nb b nb c ic valu gml gml detect rang gml gml respect two nanobodi broad spectrum quantifi content total ustilaginoidin rice sampl accord cross reactiv recognit mechan nb b nb c ustilaginoidin elucid molecular model dock key amino acid site bind nb b nb c ustilaginoidin main locat fr cdr region nb b superior nb c aspect protein express elisa titer toler organ solvent select applic detect actual contamin rice sampl total ustilaginoidin content rice sampl analyz nb b base ic elisa hplc dad result found consist develop immunoassay base nanobodi alpaca employ rapid effect method detect total utilaginoidin contamin rice sampl
|
D012275;D061905;D002161;D009183
|
T129;T116;T109;T168;T131;T015;T002
|
36,287,929
|
indoxyl sulfat might play role sarcopenia myostatin indic muscl mass patient chronic kidney diseas analysi recoveri studi serum myostatin indoxyl sulfat level increas kidney function declin may function urem toxin chronic kidney diseas ckd relat sarcopenia herein analyz associ serum myostatin level sarcopenia patient ckd perform post hoc analysi baselin data extract recoveri studi clinicaltrialsgov nct patient ckd stratifi patient two group accord median valu myostatin cutoff ngml level cutoff mgdl proport patient sarcopenia higher high level lower high myostatin level skelet muscl mass index smi handgrip strength hgs signific lower patient high level signific higher patient high myostatin level level show negat correl glomerular filtrat rate gfr smi hgs howev myostatin level posit correl smi hgs gfr sarcopenia independ associ age level adjust increas level serum total might play role sarcopenia increas level serum myostatin associ muscl mass patient ckd
|
D051436;D055948
|
T047
|
36,287,928
|
two dimension blue nativesd polyacrylamid gel electrophoresi analysi brazilian bothrop snake venom viperida snake import agent snakebit brazil protein composit snake venom frequent analyz mean electrophoret techniqu interact protein venom bare address electrophoret techniqu gain promin studi type interact blue nativ polyacrylamid gel electrophoresi bn page allow high resolut separ protein nativ form protein complex discrimin second dimens gel electrophoresi sds page lane cut bn page studi use bidimension bnsds page snake venom studi initi standard bnsds page techniqu order evalu protein interact bothrop atrox bothrop erythromela bothrop jararaca snake venom result bnsds page show nativ protein complex present snake venom metalloproteinas venom serin proteinas maintain enzymat activ bnsds page c type lectin like protein identifi western blot therefor bidimension bnsds page prove easi practic effici method separ function venom protein accord assemblag complex well analyz biolog activ detail
|
D017837;D003435
|
T123;T116;T109;T131;T014
|
36,287,927
|
impact cyanobacteria bloom aquat environ human health cyanobacteria bloom global aquat environ problem recent year due global warm water eutroph surfac cyanobacteria accumul certain area form cyanobacteria bloom driven wind cyanobacteria bloom chang physic chemic properti water caus pollut moreov cyanobacteria releas organ matter n nitrogen p phosphorus water apoptosi acceler eutroph water threaten aquat flora fauna affect communiti structur abund microorgan water simultan toxin carcinogen releas cyanobacteria enrich food chainweb endang human health studi summar analyz research influenc cyanobacteria bloom aquat environ human health help understand harm cyanobacteria bloom provid refer relat research cyanobacteria bloom
|
D000458
|
T007
|
36,287,926
|
longitudin metabolom lipidom analys reveal alter associ envenom bothrop asper daboia russelii experiment murin model longitudin metabolom lipidom analys carri blood plasma mice inject intramuscular venom viperid speci bothrop asper daboia russelii blood sampl collect h venom inject control group non envenom mice includ signific perturb metabolom lipidom observ h valu return close control mice h henc reflect transient pattern metabol disturb venom induc signific chang amino acid well sever purin pyrimidin metabolit tricarboxyl acid cycl kegg analysi metabol pathway show greatest chang includ aminoacyl trna synthesi amino acid biosynthesi metabol pathway regard lipid metabol increas triglycerid acyl carnitin concomit drop level phospholipid addit envenom mice higher level cortisol heme oxid stress marker overal pattern metabol chang envenom mice bear similar pattern describ sever traumat injuri thus underscor metabol responseadapt injuri action venom
|
D017837;D017840;D003435
|
T123;T116;T109;T131;T014
|
36,287,925
|
effect botulinum toxin therapi health relat qualiti life evalu oromandibular dystonia rate scale oromandibular dystonia omd refer focal dystonia stomatognath system health relat qualiti life hrqol isol dystonia associ non motor symptom depress anxieti pain well motor symptom evalu hrqol patient omd therapeut effect botulinum neurotoxin bont therapi assess use recent develop valid comprehens measur tool call oromandibular dystonia rate scale omdr altogeth patient jaw close dystonia n tongu lingual dystonia n jaw open dystonia n jaw deviat dystonia n jaw protrus dystonia n lip labial dystonia n evalu baselin end bont therapi stabl status total omdr score reduc signific p amp lt mean improv examin rate subscal sever disabl pain patient rate questionnair score general eat speech cosmet socialfamili life sleep annoy mood psychosoci function signific lower endpoint baselin p amp lt bont inject high posit impact patient hrqol omdr could evalu motor phenomena non motor symptom
|
D009465;D019274;D004421;D020821
|
T129;T121;T184;T048;T116;T109;T131;T039;T047
|
36,287,924
|
inhibit essenti oil growth aspergillus flavus aflatoxin b product broth poultri feed aflatoxin b afb common contamin food feed storag great harm human anim health five essenti oil thymol carvacrol cinnamaldehyd eugenol citral test inhibit effect aspergillus flavus flavus broth feed cinnamaldehyd citral proven effect flavus compar other synergist effect use simultan broth supplement cinnamaldehyd citral inocul flavus cfuml use checkerboard method mold count afb product test day similar g poultri feed supplement mixtur cinnamaldehyd citral ratio also inocul flavus paramet test day poultri feed cinnamaldehyd citral signific reduc mold count afb concentr p amp lt result show cinnamaldehyd citral posit synergi effect could inhibit least fungal growth aflatoxin b product gml broth poultri feed could altern control aflatoxin contamin food feed futur
|
D009822;D000348
|
T131;T109
|
36,287,923
|
evalu paralyt shellfish toxin marin oyster farm microalga atlant amazon evid safeti highlight potenti risk shellfish poison marin phycotoxin organ compound synthes speci microalga accumul tissu filter feeder organ bivalv mollusk toxin caus acut intox episod human sever threat aquacultur fisheri state par brazil oyster farm communiti artisan sustain base use mangrov cultiv environ seed bank small scale product often establish method safeguard health consum elev potenti risk shellfish poison outbreak studi evalu presenc phycotoxin oyster cultiv five municip region atlant amazon par brazil assess qualiti final product evalu microalga water qualiti spatio tempor variat physicochem factor area diatom domin microalga composit follow dinoflagel report potenti toxic produc paralyt shellfish toxin first time describ occurr potenti toxic dinoflagel ostreopsi sp amazon region furthermor first time toxin detect oyster farm northeast state par name gtx stx dc stx nevertheless nontox valu identifi toxin repres potenti threat shellfish consum
|
D057096;D058086;D010125;D004141
|
T204;T037
|
36,287,922
|
effect zearalenon product perform egg qualiti ovarian function gut microbiota lay hen zearalenon zen ubiquit contamin poultri feed sinc zen metabolit interfer estrogen function affect reproduct abil anim estrogen like effect zen mammal wide report littl inform avail regard effect relat low dose zen estrogen function product perform lay hen relationship work aim investig effect zen product perform egg qualiti ovarian function gut microbiota lay hen total hy line brown lay hen age week random divid group includ basal diet group bd group basal diet supplement gkg gkg zen group gkg gkg zen group zen group gkg zen result signific increas feed convers ratio fcr g feedg egg p amp lt decreas egg product p amp gt albumen height haugh unit p amp gt compar bd group serum follicl stimul hormon fsh level signific decreas zen supplement group p amp lt serum lutein hormon lh progesteron p level gkg zen group signific lower bd group p amp lt rrna sequenc indic zen reduc cecum microbi divers p amp lt alter gut microbiota composit contrast gkg zen gkg zen dramat effect gut microbiota function spearman correl analysi reveal negat correl domin bacteria gkg zen group product perform egg qualiti ovarian function hen overal zen shown exert detriment effect product perform egg qualiti ovarian function lay hen studi moreov alter composit function gut microbiota induc zen may involv advers effect zen lay hen
|
D000069196;D015025
|
T131;T007;T001;T109
|
36,287,921
|
cryaa cryba mosquito activ toxin util differ domain bind particular culex alp isoform function toxin receptor implic differenti action target larva three domain cryaa toxin produc bacillus thuringiensi subsp israelensi previous shown much toxic culex mosquito larva close relat toxin cryba interact two individu toxin target receptor suscept larval midgut cell like critic determin differenti toxic two full length membran bound alkalin phosphatas malp isoform culex quinquefasciatus larva cq malpand cq malp predict gpi link clone function express spodoptera frugiperda sf cell kda membran bound protein respect bioinformat analysi disclos cq malp isoform share signific sequenc similar aed aegypti malp cryba toxin receptor cytotox assay sf cell express cq malp cq malp show remark greater suscept cryaa cryba immunoloc studi reveal toxin capabl bind cq malp express cell membran surfac molecular dock cq malp model structur individu cri toxin reveal cryaa could bind cq malp primarili particular residu three surfac expos loop receptor bind domain dii includ thr tyr lys loop dissimilar cryba appear util certain residu c termin domain diii interact culex counterpart receptor ala substitut select loop residu ta ya ka reveal ka mutant display drastic decreas biotox c quinquefasciatus larva substitut lys asp kd reveal decreas larval toxic furthermor silico calcul bind affin chang gbind cryaa cq malp interact upon singl substitut reveal kd mutat display largest gbind valu compar three mutat signifi advers impact negat charg critic receptor bind posit altogeth present studi disclos two relat cri mosquito activ toxin conceiv exploit differ domain function bind culex membran bound alp isoform cq malp mediat differenti toxic culex target larva
|
D003465;D001413;D000330
|
T007;T204
|
36,287,920
|
develop valid lc q tof ms methodolog determin mycotoxin biomark human urin mycotoxin contamin foodstuff health concern worldwid monitor human exposur mycotoxin key concern mycotoxin metabolit excret urin reliabl detect method requir consid low level present biolog sampl aim work valid sensit methodolog capabl simultan determin ten target mycotoxin well detect untarget one use liquid chromatographi coupl quadrupol time flight mass spectrometri lc q tof ms target mycotoxin enniatin b b beauvericin aflatoxin b b g g ochratoxin sever extract procedur liquid liquid extract dilut shoot quecher assess final modifi simpl quecher extract method select creatinin adjust matrix match calibr curv requir limit detect limit quantif valu rang ngml respect recoveri achiev higher mycotoxin later method appli sampl women urin confirm applic determin intern exposur untarget mycotoxin found trichothecen zearalenon ochratoxin
|
D009183;D009793;D014255
|
T131;T123;T109
|
36,287,919
|
improv analyt approach determin tropan alkaloid leafi veget base quecher combin hplc msms work present optim methodolog base miniatur origin quecher quecher follow liquid chromatographi coupl mass spectrometri hplc msms determin tropan alkaloid tas atropin scopolamin leafi veget sampl analyt methodolog success valid demonstr quantit limit mql ngg good accuraci precis recoveri rsd analyt method appli analysi ta produc plant brugmansia versicolor solandra maxima convolvulus arvensi high concentr scopolamin found flower mgkg leav mgkg b versicolor highest concentr atropin found flower maxima mgkg commerci mix leafi veget contamin b versicolor maxima analys verifi efficaci method show recoveri analyt final method appli analysi eighteen sampl leafi veget find atropin three sampl mix leafi veget concentr ngg nine sampl concentr mql turn scopolamin found sampl chop swiss chard concentr mql
|
D014675;D053719
|
T063;T168
|
36,287,918
|
vitro vivo inhibitori activ select tradit medicin plant toxin induc cyto entero toxic cholera careya arborea punica granatum psidium guajava holarrhena antidysenterica aegl marmelo piper longum common use tradit medicin diarrhoeal diseas india studi investig inhibitori activ plant cytotox enterotox induc toxin secret vibrio cholera cholera toxin ct non membran damag cytotoxin nmdci cell free cultur filtrat cfcf v cholera quantifi use gm elisa cell base assay respect hydro alcohol extract plant lyophil juic p granatum test ct induc elev camp level cho cell line bind ct gangliosid gm receptor nmdci induc cytotox signific reduct camp level cfcf treat cho cell line observ extract except p longum c arborea p granatum h antidysenterica marmelo show amp gt bind inhibit ct gm receptor c arborea p granatum p guajava effect decreas cytotox morpholog alter caus nmdci cho cell line efficaci three plant cfcf induc enterotox seen adult mice ligat ileal loop model evidenc decreas volum fluid accumul camp level ligat ileal tissu histopatholog chang intestin mucosa therefor plant valid clinic use cholera
|
D002771;D010946;D014734;D014118
|
T123;T007;T131;T047;T002
|
36,287,917
|
homeostasi gut microbiota chronic kidney diseas gut microbiota consist trillion microorgan fulfil import role metabol nutrit intak physiolog matur immun system also aid abet progress chronic kidney diseas ckd human gut microbiom consist bacteri speci five major bacteri phyla name firmicut bacteroidet actinobacteria proteobacteria verrucomicrobia alter member phyla alter total gut microbiota declin number symbiot flora increas pathogen bacteria caus aggrav ckd addit ckd associ alter intestin microbiom result metabol chang accumul amin indol phenol among urem metabolit feedforward advers effect ckd patient inhibit renal function increas comorbid atherosclerosi cardiovascular diseas cvd classif urem toxin accord degre known toxic base experiment evid toxic number system affect overal experiment clinic evid select identifi repres urem toxin small water solubl compound protein bound compound middl molecul relat gut microbiota summar gut deriv urem metabolit accumul ckd patient exhibit cell damag properti damag intestin epitheli cell wall increas gut permeabl lead transloc bacteria endotoxin gut circulatori system elev level endotoxin lead endotoxemia inflamm acceler ckd progress recent year role gut microbiom ckd pathophysiolog emerg import aspect correct treatment howev mechan gut microbiota contribut ckd progress still complet understood therefor review summar current state research regard ckd gut microbiota alter microbiom urem toxin product gut epitheli barrier degrad
|
D000069196;D051436
|
T047;T007;T001
|
36,287,914
|
baicalin lipid nanocapsul treatment glioma character mechanist cytotox pharmacokinet evalu baicalin promis anticanc nutraceut compound applic hinder low water solubl bioavail remedi encapsul nanoparticl
|
D053769;D005910
|
T191;T073
|
36,287,818
|
radiat dose reduct opportun vascular imag comput tomographi angiographi cta gold standard imag modal vascular imag due varieti factor includ widespread avail comput tomographi ct scanner eas speed imag acquisit high sensit cta vascular patholog howev radiat dose experienc patient imag long concern imag acquisit method advanc ct imag acquisit techniqu combin advanc non ioniz radiat imag techniqu includ magnet reson angiographi mra contrast enhanc ultrasound ceus present grow opportun reduc total radiat dose patient review provid overview advanc imag technolog acquisit techniqu help minim radiat dose associ vascular imag
|
D000084862;D018810
|
T061;T060
|
36,287,817
|
vascular choroid alter uncompl third trimest pregnanc purpos evalu anatomi perfus choroid substructur third trimest pregnant women use optic coher tomographi oct oct angiographi octa imag method cross section studi women third trimest uncompl pregnanc non pregnant age match women recruit particip underw enhanc depth imag edi oct octa subfov choroid thick sfct well choroid sublay perfus compar group result total eye pregnant eye non pregnant women includ median age group year median sfct pregnant group non pregnant cohort p median choriocapillari perfus ccp signific lower pregnant group vs p moreov haller layer perfus correl signific mean arteri pressur non pregnant women cc p pregnant one cc p conclus sfct found thinner ccp lower third trimest pregnant women hormon chang pregnanc consecut impact autoregul small choroid vessel might play import role therefor alter choroid measur third trimest pregnanc care evalu extent could normal physiolog chang
|
D002829;D041623
|
T060;T023;T024
|
36,287,816
|
tip trick success percutan cryoablat larg renal cell carcinoma percutan cryoablat prove safe effect treatment stage ta renal cell carcinoma rcc patient larger size rccs may good surgic candid may tumor locat anatom unfavor locat make partial nephrectomi challeng patient popul percutan cryoablat consid treatment option given less invas natur compar surgeri ablat larger size rccs requir care plan ensur tumor volum complet cover within ablat zone minim risk non target injuri surround critic organ articl share institut experi treat larger size rccs gt cm use percutan cryoablat alon discuss strategi maxim volum ablat zone precis placement probe also shed light differ techniqu protect surround structur cryoablat
|
D002292;D003452;D007680
|
T061;T191
|
36,287,815
|
structur function pulmonari assess sever covid survivor month discharg long term pulmonari sequela covid patient current investig worldwid potenti relationship blood sampl function radiolog find crucial guid follow studi collect evalu clinic status name symptom patient report outcom pulmonari function test pft laboratori test radiolog find month post discharg patient admit februari may surviv sever covid pneumonia histori chronic pulmonari diseas covid unrel complic use exclus criteria unenhanc cts analyz quantit compromis lung volum qualit main pattern ground glass opac ggo consolid reticular configur patient subsequ divid group base radiolog trend accord evolut percentag compromis lung volum month post discharg seventi one patient show signific improv laboratori test pft among patient also underw ct examin patient negat ct find three month n negat ct also month among patient present ct alter three month normal improv remain stabli abnorm worsen dimer valu low patient normal ct higher case improv stabli abnorm ct median valu vs vs ngml respect overal compromis lung volum reduc compar three month post discharg vs p lt stabli abnorm ct main pulmonari pattern chang show reduct ggo increas reticular configur summar pft normal covid survivor month post discharg ct structur abnorm persist although sensibl improv time associ higher dimer valu
|
D000086382;D008171
|
T047;T067
|
36,287,814
|
singl breath chemic shift imag hyperpolar xe mri healthi cf ipf copd subject singl breath chemic shift imag sbcsi hybrid mr spectroscop imag modal use hyperpolar xenon gas xe differenti lung diseas probe function characterist studi test efficaci sbcsi differenti physiolog among pulmonari diseas total subject healthi idiopath pulmonari fibrosi ipf cystic fibrosi cf chronic obstruct pulmonari diseas copd given forc vital capac fvc hyperpolar xe inhal mri acquisit proton xe ventil sbcsi imag acquir separ breath hold use radiofrequ chest coil tune xe xe spectrum analyz lung voxel ratio spectroscop peak chemic shift relax cf copd subject signific ventil defect ipf healthi subject correl fev predict r fev predict correl well rbcgas ratio r copd ipf signific higher tissuerbc ratio subject longer rbc relax time greater rbc chemic shift cf subject ventil defect healthi subject elev tissuerbc ratio shorter tissu relax greater rbc chemic shift sbcsi may help detect character pulmonari diseas follow treatment efficaci predict diseas outcom
|
D054990;D003550;D029424
|
T047
|
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