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biomedical-topic-categorization-validation

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36,284,936
investig parasit protozoa drink water samarra iraq protozoan parasit import drink water product system cystic form stabl environ resist convent disinfect method present studi aim investig protozoan parasit drink water differ place samarra iraq end sampl tap drink water collect place samarra iraq ie al sekek al kadesia alzeraa al shuhdaa al muthana al shorta al mamal al khedraa al efraz al jubereaa begin decemb end februari sampl collect water sampl examin detect oocyst cyst protozoan parasit use direct wet smear lugol iodin modifi ziehl nelseen stain method result indic sampl investig infect protozoan parasit ratio diagnost parasit sampl investig determin entamoeba histolytica giardia lamblia cryptosporidium parvum find reveal presenc protozoan parasit drink water area studi specifi need rapid improv monitor system treatment drink water control diseas caus pathogen well identifi sourc contamin
D060766;D003457;D003458;D010271
T047;T204;T167
36,284,891
investig covid outbreak region prison northern uganda septemb despit implement measur prevent introduct covid prison covid outbreak occur moroto prison northern uganda septemb investig factor associ introduct spread covid prison case pcr confirm sar cov infect prisonerstaff moroto prison august septemb review prison medic record identifi case patient interview prison hospit staff understand possibl infect mechan index case patient opportun spread retrospect cohort studi interview prison avail staff identifi risk factor data analyz use log binomi regress septemb recent hospit prison unrecogn sar cov infect admit moroto prison quarantin becom infect share hospit ward subsequ diagnos covid patient sampl taken hospit prison august test posit septemb mass reactiv test prison septemb reveal infect among prison staff overal attack rate one prison staff one prison care sick prison hospit enter main prison without quarantin test posit septemb food clean servic provid also regular transit quarantin unrestrict prison area use facemask time adjust risk ratio arr ci combin handwash touch surfac arr ci protect prison recent transfer facil moroto prison increas risk infect arr ci covid like introduc moroto prison quarantin prison hospit acquir infect delay test result andor caretak quarantin hospit exposur outbreak may amplifi via share foodclean servic provid transit quarantin non quarantin prison facemask handwash protect reduc test turnaround time hospit prison could avert outbreak test incom prison sar cov quarantin provid unrestrict soapwat handwash univers facemask use prison could mitig risk futur outbreak
D011330;D000086382
T047;T073;T067
36,284,890
real world applic challeng implic artifici intellig healthcar essay essay examin state artifici intellig ai base technolog applic healthcar impact industri studi compris detail review literatur analyz real world exampl ai applic healthcar find show major hospit use ai base technolog enhanc knowledg skill healthcar profession patient diagnosi treatment ai system also shown improv effici manag hospit nurs manageri function healthcar provid posit accept ai multipl arena howev applic offer utopian new opportun well dystopian challeng unlik pessimist ai seen potenti sourc digit dictatorship futur nd centuri provid balanc view potenti challeng ai healthcar discuss detail evid ai relat technolog rapid evolv allow care provid creat new valu patient improv oper effici effect ai applic requir plan strategi transform care servic oper order reap benefit
D001185;D003695
T090;T073;T093;T066;T058
36,284,889
knot doubl j ureter stent case report literatur review mani complic due doubl j dj stent placement report dj stent knot rare complic case report literatur present case dj stent knot review literatur regard complic report year old man histori cystinuria ureter stone manag retrograd ureteroscopi holmium laser three month ago patient come dj stent remov first tri remov dj stent via cystoscop procedur fail fluoroscop imag reveal knot dj stent lodg ureteropelv junction remov via holmium laser ureteroscop procedur without complic conclus cystoscop procedur simpl traction fail remov dj stent multimod urolog procedur holmium laser tri especi patient urolithiasi predispos factor
D014513;D014514
T023;T047
36,284,887
health relat qualiti life among patient chronic diseas covid pandem cross section studi last two year covid larg chang rhythm human life overwhelm healthcar system global patient pre exist chronic diseas wors outcom covid pandem
D000086382
T047;T067
36,284,886
knowledg school teacher associ factor effect deliveri school health programm nigeria import posit teacher occupi school set make indispens effect deliveri school health programm shp studi assess shp knowledg primari school teacher percept role success deliveri programm ondo state nigeria
D000070777;D007722
T053;T097
36,284,885
posterior revers encephalopathi syndrom patient preeclampsia case report revers posterior encephalopathi syndrom pres rare clinico radiolog syndrom diagnosi suspect pregnant women suffer eclampsia brain ct scan show radiolog imag suggest diseas report case year old pregnant woman week gestat histori pre eclampsia present convuls seizur high blood pressur follow cesarean section patient admit intens care unit clinic radiolog investig reveal pres syndrom clinic cours favor control blood pressur appropri treatment anticonvuls therapi revers posterior encephalopathi syndrom neurolog manifest rare occur patient pre eclampsia except diagnosi suspect patient neurolog sign brain mri best diagnost tool
D054038;D011225;D001927
T047;T046
36,284,884
preval factor associ smoke among adult live moungali district brazzavill tobacco epidem real public health problem world africa purpos studi estim preval identifi factor associ smoke among adult live moungali district
D012907;D000428
T055
36,284,883
pleuropneumoblastoma case report rare pediatr tumor pleuropulmonari blastoma rare intrathorac tumor children associ poor prognosi diagnosi base histolog examin conduct didact studi involv year old child sever acut respiratori distress associ hemothorax radiolog thoracoscop examin suggest malign pleuropulmonari process anatomopatholog examin radio clinic comparison allow diagnosi solid cystic pleuropulmonari blastoma type ii unfortun given sever clinic featur child die within week due multipl organ failur pathologist experi import recogn diseas start adequ treatment soon possibl allow tumor regress rate neoadjuv treatment year surviv rate least aggress form solid solido cystic tumor
D008175;D018202
T191
36,284,882
isol laryng tuberculosi uncommon manifest extrapulmonari tuberculosi adult case report isol laryng tuberculosi rare sometim difficult diagnos common caus laryng granuloma report case year old man particular past medic histori hospit due paroxysm laryng dyspnea dysphagia solid food dysphonia evolv month without associ sign laryngoscop examin show polyploid format mask glottic floor histolog examin reveal epithelioid gigantocellular granuloma without caseous necrosi direct microscop examin cultur negat diagnosi isol laryng tuberculosi made base endem countri absenc argument favor anoth type granulomatosi anti tuberculosi therapi combin oral corticosteroid indic base presenc sever upper airway edema symptom resolv day treatment
D014387;D014376
T047
36,284,673
use optic coher tomographi angiographi biomark retinopathi sever treatment diabet retinopathi goal evalu optic coher tomographi angiographi oct biomark correl retin vessel densiti vd diabet retinopathi dr sever visual acuiti well track antivascular endotheli growth factor vegf treatment efficaci
D003930;D003920
T047
36,284,672
hyposmot stress caus atp releas discret zone within outer cortex rat len purinerg signal pathway activ extracellular atp implic regul len volum transpar studi investig locat atp releas whole rat lens mechan osmot challeng alter atp releas
D011339;D002229
T121;T109
36,284,671
untarget metabolom analysi aqueous humor diabet macular edema mechan diabet macular edema dme explor compar intraocular metabolit profil aqueous humor patient dme diabet patient without dme use untarget metabolom analysi
D008269;D003930;D003924
T047
36,284,670
identif numer novel diseas caus variant patient inherit retin diseas combin care clinic function phenotyp systemat broad ngs panel base genotyp widespread consensus genotyp essenti patient inherit retin diseas ird given numer ongo gene therapi clinic trial ird identifi pathogen mutat patient potenti import therapeut implic studi demonstr identifi high degre confid numer novel diseas caus mutat delet duplic larg consecut ird case seri use judici combin care depth clinic function phenotyp guid integr genotyp approach
D012164;D012162
T047;T046
36,284,669
nestin contribut laser choroid retin neovascular choroid retin neovascular play essenti role various ocular diseas studi examin role nestin process nestin intermedi filament protein known play sever role includ marker neural progenitor prolifer endotheli cell
D015861;D020256
T047;T046
36,284,668
long noncod rna malatmicrorna p axi regul prolifer apoptosi retinoblastoma cell pikakt pathway studi design dissect role long noncod rna metastasi associ lung adenocarcinoma transcript malat retinoblastoma rb under mechan
D062085;D012175;D035683;D019572;D001688
T121;T123;T191;T114
36,284,667
phenotyp spectrum adamtsl associ ectopia lenti addit case complic review literatur adamtsl associ ectopia lenti rare autosom recess condit primarili associ crystallin len displac howev preval ocular system manifest condit poor understood studi summar ocular system phenotyp spectrum condit
D004479;D012163;D005901
T019;T047
36,284,576
puzzl pain nodul back case report cutan leiomyoma known aris three locat viz arrector pili muscl darto muscl scrotal sac smooth muscl layer blood vessel cutan piloleiomyoma aris arrector pili uncommon benign skin tumor present clinic singl numer pain nodul either appear diffus zosteriformsegment rare case report unusu case multipl tender papulonodular lesion right infrascapular region histolog one nodul show dermal tumor consist interlac fascicl spindl cell consist diagnosi piloleiomyoma prescrib patient oral calcium channel blocker amlodipin provid symptomat relief pain consid use treat similar case
D007889;D012878
T191
36,284,575
mental health lifestyl mental health nurs cross section nation wide studi uganda covid time mental health nurs mhns work potenti high stress set particular low incom countri covid pandem risk might high multi centr cross section studi explor preval psycholog distress post traumat stress disord ptsd symptom among ugandan mhns investig associ mental health outcom lifestyl factor
D000086382;D013313
T047;T067;T048
36,284,574
implement covid laboratori test certif program coltep zimbabw africa union au trust travel initi introduc support africa union member state enhanc current health screen system trust travel offer onlin digit platform verif authent covid result base collabor effort across network particip covid test laboratori paper describ certif process laboratori qualifi list au trust travel platform approv recogn covid test facil checklist prepar iso iso world health organ laboratori safeti manual th edit use audit laboratori approv auditor complet audit checklist review laboratori document record observ laboratori oper whilst ask open end question clarifi document seen observ made laboratori recommend certif score least may septemb total medic laboratori author sar cov test audit coltep certif zimbabw major attain star rate attain star perform highest area test result data manag mean score sd least perform laboratori laboratori biosafeti biosecur mean score sd qualiti control assur mean score sd need laboratori commit resourc qualiti assur program train laboratori personnel biosafeti biosecur part continu qualiti improv
D000086382;D000086742;D007753
T073;T067;T059;T093;T047
36,284,573
famili occurr concomit imperfor hymen transvers vagin septum case report imperfor hymen transvers vagin septum femal reproduct tract abnorm concurr occurr rare far manifest anomali within famili report literatur report first famili case two sister mention abnorm patient youngest sister year old present cyclic lower abdomin pain clinic imag examin show imperfor hymen hematometrocolpo addit surgeri confirm low transvers vagin septum resect use virgin preserv procedur conclus presenc mention abnorm sibl reflect potenti genet etiolog also order avoid late diagnost anomali imperfor hymen must screen birth room
D006924;D014623
T023;T047
36,284,572
chromophob renal cell carcinoma liposarcomat dedifferenti case report chromophob renal cell carcinoma liposarcomat dedifferenti extrem rare tumor case report literatur report case year old woman present pain palpabl mass right flank abdomin comput tomographi ct scan found renal tumor patient underw right radic nephrectomi adren gland resect histolog examin specimen complet immunohistochem molecular studi diagnosi chromophob renal cell carcinoma liposarcomat dedifferenti made patient receiv adjuv chemotherapi afterward develop bone metastasi die month surgeri chromophob renal cell carcinoma liposarcomat dedifferenti rare tumor associ poor prognosi metastat potenti
D002292;D007680;D001859
T191
36,284,571
undiagnos hypertens sudan result cross section nation step survey rate hypertens increas africa studi aim estim preval associ factor undiagnos hypertens htn among adult sudan
D006973
T047
36,284,570
post covid rhinocerebr mucormycosi case report literatur review pandem coronavirus diseas covid still remain upsurg trend second wave diseas led panic mani countri part world suffer fourth wave midst pandem covid patient acquir secondari infect mucormycosi also known black fungus diseas mucormycosi serious rare opportunist fungal infect spread rapid henc prompt diagnosi treatment necessari avoid mortal morbid rate report paper case diabet patient present bilater nasal obstruct anosmia frontal headach diagnos rhinocerebr mucormycosi develop covid infect favor outcom medico surgic treatment case aim awar patrician possibl associ import earli diagnosi optim treatment outcom
D009091;D000086382;D009894;D003920
T047;T067
36,284,569
late onset darier diseas genet predispos individu case report keratosi folliculari also call darier diseas rare autosom domin cutan diseas character greasi keratot sometim crust red brown papul plaqu seborrh area flexur nail abnorm well establish diseas begin age year peak onset puberti diseas tend manifest earli especi famili histori diseas herebi report case darier diseas special interest late onset present despit signific famili histori diseas along clinicopatholog dermoscop featur also highlight use non invas investig techniqu dermoscopi tool diagnos diseas
D007644
T019;T047;T191
36,284,568
erythroblastopenia primari myelofibrosi rare associ case report combin erythroblastopenia primari myelofibrosi rare report unusu case year old moroccan patient follow sinc idiopath erythroblastopenia initi treat corticotherapi ciclosporin two year later patient report bone pain splenomegali assess includ myelogram bone marrow biopsi molecular biolog show myelofibrosi etiolog assess myelofibrosi negat confirm primit natur patient receiv ruxolitinib transfus support patient outcom favor mark improv general condit splenomegali transfus rate associ erythroblastopenia myeloprolif disord except case report literatur
D055728;D012010
T047;T191
36,284,563
comeback one health global health let us make mistak covid pandem led rediscoveri concept one health idea anim human environ intim link new concept still labil contribut inevit confus still lack action ground one health fail integr three dimens editori aim share six challeng implement one health approach order avoid pitfal global health initi one health programm relev sustain without activ involv communiti deploy impli necessari decolonis health ie rethink programm govern financ formul implement evalu citizen countri concern done without address social inequ health power issu approach lead question exploit model agricultur natur resourc think one health impli think issu intervent intersector inclus participatori perspect interdisciplinari transdisciplinari perspect understand result complex final research find taken account build public action consid differ challeng adopt system interdisciplinari perspect anchor local context accord participatori inclus approach thus seem essenti us respond appropri relev sustain manner issu associ one health
D000086382;D000074823
T078;T047;T067
36,284,562
compar studi patient hospit sar cov infect two consecut wave tunisia sinc decemb novel coronavirus sar cov trigger global pandem heavi medic societ econom toll health consequ similar success wave affect sever countri aim studi compar sociodemograph clinic evolutionari featur covid patient hospit militari hospit tuni hmpit nd rd wave affect countri
D000086382;D012128
T047;T067
36,284,561
trend hiv syphili preval among pregnant women antenat clinic togo analysi sentinel serosurveil result aim work analys trend hiv infect syphili among pregnant women prenat consult pnc healthcar facil togo
D013587;D015658;D011251
T047
36,284,560
communic address popul health literaci concept health literaci wide use english speak countri year howev mean evolv sinc first definit cognit social skill determin motiv abil individu gain access understand use inform way promot maintain good health often center narrow mean function health literaci abil read understand written medic document narrow definit exclud illiter popul nt take consider social skill moreov nt take consider barrier erect cultur work field health communic propos broadest concept health cultur encompass health literaci well represent influenc peopl decis health health cultur approach make possibl base strategi messag communic tool represent target popul order sensit behavior chang promot communic show exampl applic public health program sub saharan africa breastfeed pregnanc support ebola virus diseas hiv test tuberculosi covid
D000086382;D057220;D058015;D000075485
T041;T047;T058;T067
36,284,557
nasal myiasi due lucilia sp intub patient one case morocco myiasi infest live bodi anim human fli larva maggot accident obligatori parasit grow three stage host feed tissu myiasi hospit area rare situat fli accident lay egg patient most open wound caviti case present report case year old patient admit general surgeri depart periton intens care unit icu septic shock intub maggot seen move nasal caviti day admiss sent laboratori examin larva identifi third larval stage lucilia sp remov entir intens nasal wash check examin nasal caviti reveal evid infest nasal wash larva seen unfortun patient die septic shock day later
D012772;D009198;D004175
T047;T046;T204
36,284,556
hydatidosi psoa muscl reveal vascular axi compress lower limb one case ibn sina univers hospit rabat morocco hydatidosi zoonosi caus echinococcus granulosus real public health problem morocco muscl local unusu even endem countri report rare describ case hydatid cyst psoa muscl diagnos laboratori
D004443;D048209;D004446;D014648
T047;T204
36,284,555
covid manag region hospit lambarn gabon march februari author report experi manag covid region hospit lambarn capit moyen ogoou provinc central gabonth infecti diseas depart referr follow site covid intervent team follow outpati depart follow nation recommend overal manag mild case receiv vitamin therapi moder case hydroxychloroquin azithromycin sever case azithromycin anoth antibiot oxygenov year case rt pcr recruit hospit comorbid sever sign averag durat hospit daysthes case compos mild case cure symptomat treatment moder case treat cure sever case treat azithromycin plus second antibiot cure without sequela sequela death co infect hiv case follow outpati depart recov distribut follow asymptomat without co morbid untreat mild sign vitamin moder sign treat azithromycin hchq vitaminsin total case recov without sequela except patient sequela death receiv treatment howev death occur diagnosi made strategi encount difficulti term overload carer feed patient
D006886;D000086382
T121;T047;T067;T109
36,284,554
takayasu diseas underdiagnos entiti sub saharan africa report five gabones case takayasu diseas tm vascul aorta main branch infecti diseas especi mycobacterium tuberculosi trigger develop tm hypersensit reaction paradox case diseas report literatur review
D013625;D009169
T047;T007
36,284,553
sacroili erysipelothrix rhusiopathia reveal tricuspid endocard first case report guiana shield clinic case review literatur report atyp case acut sacroili caus erysipelothrix rhusiopathia reveal tricuspid endocard year old woman without medic histori admit cayenn hospit intens right hip thigh pain associ fever right sacroili visibl comput tomographi ct scan confirm mri transesophag echocardiographi reveal larg mobil tricuspid veget blood cultur posit e rhusiopathia ct scan show pulmonari alveolar opac consist septic emboli clinic improv obtain ceftriaxon follow ciprofloxacin week treatment present review bone joint infect caus e rhusiopathia far singl case report latin america
D004888;D004889;D058566;D004696
T047;T007
36,284,501
make feel develop pilot test two new instrument measur emot attribut experi childhood sexual abus though prior research demonstr survivor childhood sexual abus may experi rang negat emot follow abus studi fail consid conflict ambival posit emot attribut experi survivor current studi describ develop pilot two new scale captur posit negat emot youth may attribut experi childhood sexual abus sampl youth n recruit survey communiti correct residenti treatment center midwestern state item respons theori use test perform measur individu item subsampl youth report histori childhood sexual abus n new measur demonstr high intern consist reliabl appropri captur rang posit negat emot youth may experi follow childhood sexual abus find indic youth experienc childhood sexual abus may conflict posit negat emot associ experi implic measur refin futur research direct clinic practic discuss
D002650;D002649
T048
36,284,468
evalu orthodont mini implant placement maxillari anterior alveolar region patient cone beam comput tomographi singl center south india background studi aim evalu orthodont mini implant placement maxillari anterior alveolar region cone beam comput tomographi cbct patient singl center south india materi method total cbct scan orthodont patient complet level align stage includ thick labial alveolar bone labio palat bone inter radicular distanc maxillari central incisor u u maxillari central later incisor u u maxillari later incisor canin u u vertic level mm mm mm interdent cementoenamel junction measur descript statist anova tukey post hoc test done assess differ among group independ test done analyz differ sex result thick cortic bone labial region higher u u site u u site height mm also signific differ mm mm height u u region signific differ note bone dimens among men women labio palat bone thick among differ site inter radicular distanc highest u u site lowest u u site conclus find center show cbct use evalu orthodont mini implant placement maxillari anterior alveolar region u u u u locat height mm mm apic interdent cementoenamel junction optim placement mini implant
D015921;D052280
T061;T074
36,284,464
coronari subclavian steal syndrom year old woman present angiograph confirm subclavian arteri stenosi proxim left intern mammari background coronari subclavian steal syndrom csss uncommon condit high grade stenosi subclavian arteri proxim intern mammari arteri bypass graft result retrograd blood flow bypass graft report csss year old woman present ventricular tachycardia angiograph confirm subclavian arteri stenosi proxim left intern mammari arteri lima bypass graft year follow coronari arteri bypass graft cabg case report patient year old woman past medic histori multivessel coronari arteri diseas found preoper evalu underw vessel cabg found ischem cardiomyopathi eject fraction despit revascular implant cardiac defibril icd three year follow uncompl cabg patient present angina sustain ventricular tachycardia icd therapi unsuccess ischemia etiolog sustain ventricular tachycardia patient underw cardiac catheter demonstr high grade subclavian arteri stenosi proxim lima bypass graft intervent lesion nativ left anterior descend arteri done placement mm drug elut stent patient respond well treatment subsequ ventricular tachycardia outpati follow conclus report shown patient present symptom acut coronari syndrom histori cabg involv lima possibl csss consid investig coronari arteri imag diagnosi manag delay
D013349;D058686;D054855;D017180
T047;T074;T046
36,284,456
comparison lock compress plate distal femor replac periprosthet distal femor fractur retrospect studi compar clinic outcom lock compress plate lcp distal femor replac dfr periprosthet distal femor fractur pdffs total knee arthroplasti
D005264;D057068
T047;T037
36,284,454
studi analges efficaci rectus sheath block singl port total laparoscop hysterectomi random control studi investig postop analges effect rectus sheath block rsb combin patient control analgesia pca compar pca alon singl port total laparoscop hysterectomi tlh
D009407;D010535
T061;T060
36,284,451
assess drug substanc abus preval cross section studi among undergradu select southwestern univers nigeria cross section studi aim assess preval awar drug substanc abus among undergradu four southwestern univers nigeria
D014147;D019966
T033;T121;T048;T109
36,284,449
distinguish apathi depress older adult mild cognit impair use text audio video base multiclass classif shape addit explan studi aim develop classif model detect distinguish apathi depress base text audio video featur make use shape addit explan shap toolkit increas model interpret
D057565;D060825
T048
36,284,363
apo depend effect earli amyloid patholog induc neuron patient alzheim diseas allel apolipoprotein e apo strongest known genet risk factor late onset alzheim diseas ad associ amyloid pathogenesi howev clear apo acceler amyloid beta deposit seed stage amyloid develop ad patient neuron
D000544;D000686
T047;T048
36,284,362
matrix gla protein mgp gata trps novel diagnost panel determin breast origin metastat breast carcinoma common consid differenti diagnosi metastat diseas detect femal addit tumor morpholog document clinic histori sensit specif immunohistochem ihc marker gcdfp mammaglobin gata help determin breast origin howev marker report show lower sensit certain subtyp tripl negat breast cancer tnbc
D064726;D001943
T191
36,284,361
insert seq enabl high resolut map genom integr dna use nanopor sequenc comprehens characteris genom engin technolog relev develop safe use human gene therapi short read base method overlook insert event repetit region develop insert seq method combin target amplif integr dna umi base correct pcr bias oxford nanopor long read sequenc robust analysi dna integr experiment pipelin improv number mappabl insert repetit region larger repeat process comput peak call pipelin insert seq simpl cheap robust method quantit characteris dna integr divers ex vivo vivo sampl
D000081414
T063
36,284,360
chest dual energi ct assess effect steroid lung function sever covid patient steroid shown reduc inflamm hypox pulmonari vasoconstrict hpv lung edema base evid clinic trial steroid wide use sever covid howev effect steroid pulmonari gas volum blood volum group patient unexplor
D000086382;D030361
T047;T067
36,284,359
assess helicobact pylori posit infect patient accord clarithromycin resist rrna rpl associ mutat cypc gene pattern earli stage gastriti clarithromycin resist helicobact pylori cam r main caus standard tripl therapi erad failur proton pump inhibitor ppis direct pose bacteriocid activ prepar optimum condit clarithromycin best function counter poor metabol subject homozygot extens metabol well character treatment failur eventu determin cam r profil estim ppis metabol rate support clinician better prescript explor helicobact pylorimut rrna rpl resist gene cypc allel variat ppis metabol pattern patient consequ result report physician
D016480;D016481;D001189;D005756
T047;T007;T126;T116
36,284,358
ankl strategi assist improv gait stabil use control base shoe center pressur degre freedom power ankl foot orthos clinic studi although ankl strategi import achiev frontal plane stabil one leg stanc previous develop power ankl foot orthos pafo involv ankl strategi hardwar limit weak movement frontal plane factor deterior gait stabil increas fall risk overlook rehabilit therefor use pafo subtalar joint frontal plane movement tri confirm exist import balanc clinic experi
D000843;D061826
T074;T030
36,284,357
crispr cas mediat function dissect foxc genom region zebrafish identifi critic conserv cis regulatori element foxc encod forkhead domain transcript factor associ sever ocular disord correct foxc dosag critic normal develop yet mechan control express remain unknown togeth foxq foxf foxc part cluster fox gene conserv vertebr crispr cas mediat dissect genom sequenc surround two zebrafish ortholog foxc perform includ five zebrafish human conserv region three downstream foxca two remot upstream foxfafoxca foxfbfoxcb cluster well two intergen region foxcab foxfab lack sequenc conserv posit correspond area encompass previous report glaucoma associ snp human remov downstream sequenc alter foxca express moreov zebrafish carri delet two three downstream element demonstr abnorm phenotyp includ enlarg anterior chamber eye reminisc human congenit glaucoma delet distant upstream conserv element influenc express foxfab foxqab foxcab within cluster remov either intergen sequenc reduc foxca foxcb express late develop suggest role transcript regul despit lack conserv nucleotid level studi identifi region human patient may explain addit individu development ocular disord
D015027;D005901
T047;T013
36,284,354
reliabl valid japanes movement imageri questionnair revis second version develop japanes version movement imageri questionnair revis second version miq rs essenti widespread evalu treatment base motor imageri physic disabl person patient rehabilit studi aim investig reliabl valid movement imageri questionnair revis second version miq rs assess motor imageri abil translat japanes
D019018;D007699
T061;T040
36,284,353
beyond three chamber test toward multimod object assess social behavior rodent main recent year substanti advanc social neurosci realiz includ generat numer rodent model autism spectrum disord still argu method current use analyz anim social behavior creat bottleneck signific slow progress field inde bulk research still reli small number simpl behavior paradigm result assess without consid behavior dynam moreov variabl examin paradigm thus overlook signific portion complex character social interact two conspecif subsequ hinder understand neural mechan govern differ aspect social behavior demonstr constraint discuss common use paradigm assess rodent social behavior three chamber test also point fact although emot great influenc human social behavior lack reliabl mean assess emot state anim social task also discuss current evid support exist pro social emot emot cognit anim model suggest adequ social behavior analysi requir novel multimod approach employ autom simultan measur multipl behavior physiolog variabl high tempor resolut social interact anim accord describ sever computer system comput tool acquir analyz measur final address sever behavior physiolog variabl use assess socio emot state anim model thus elucid intricaci social behavior attain deeper insight brain mechan mediat behavior conclus summari suggest combin autom multimod measur machin learn algorithm help defin socio emot state determin dynam various type social task thus enabl thorough understand complex social behavior
D012377;D000067877
T015;T048
36,284,352
autoimmun gene express profil fingerstick whole blood chronic fatigu syndrom myalgic encephalomyelitischron fatigu syndrom mecf debilit condit lead sever impair physic psycholog cognit social occup function caus mecf remain incomplet understood clinic diagnost test mecf although mani therapi use label manag symptom mecf limit specif therapi cure mecf studi investig express gene specif key immun function viral infect status mecf patient aim identifi biomark character andor treatment diseas
D015673;D001327
T047
36,284,351
myelin repair alzheim diseas review biolog pathway potenti therapeut literatur review investig signific overlap myelin repair signal pathway pathway known contribut hallmark patholog alzheim diseas ad discuss previous investig therapeut target amyloid tau apo well potenti therapeut target empir shown contribut remyelin progress ad current evid show multipl ad relev pathway overlap signific remyelin myelin repair encourag oligodendrocyt prolifer matur myelin product present need singl cohes model myelin homeostasi ad determin causat pathway beyond scope review may possibl investig patholog overlap myelin repair ad therapeut approach
D000544;D000074586
T047;T043;T048
36,284,350
virtual augment realiti critic care medicin patient clinician research perspect virtual realiti vr augment realiti ar aspir new technolog increas use critic care medicin vr fulli immers user virtual three dimension space ar add overlaid virtual element real world environ vr ar offer great potenti improv critic care medicin patient relat health care provid vr may help amelior anxieti stress fear pain patient may assist patient mobilis rehabilit improv communic involv patient care ar effect tool support continu educ intens care medicin provid may complement tradit learn method acquir key practic compet central venous line placement cardiopulmonari resuscit extracorpor membran oxygen devic manag endotrach intub current technic human ethic challeng remain adapt integr vrar modal use clinic applic use routin icu challeng user may experi unwant side effect call cybersick vrar session may limit applic furthermor critic ill patient one vulner patient group warrant special ethic consider new technolog introduc daili care date studi involv arvr critic care medicin provid low level evid due research design summaris background inform current develop key consider taken account futur scientif investig field
D000081411;D000076142
T170;T066
36,284,349
immun checkpoint b h cancer immunolog clinic immunotherapi immunotherapi cancer rapid develop treatment modifi immun system enhanc antitumor immun respons b h cd member b famili play immunoregulatori role cell respons highlight novel potenti target cancer immunotherapi b h shown play inhibitori role cell activ prolifer particip tumor immun evas influenc immun respons tumor behavior differ signal pathway b h express found aberr upregul mani differ cancer type associ b h express poor prognosi establish immunotherapi target b h differ approach develop rapid mani ongo clinic trial explor safeti efficaci profil therapi cancer review summar emerg research function under pathway b h express role b h differ cancer type advanc b h target therapi consid differ tumor microenviron characterist result preclin model clinic practic research indic b h promis target futur immunotherapi might eventu contribut improv cancer immunotherapi benefit patient
D060887;D009369
T129;T191;T116
36,284,347
direct identif hla class class ii restrict cell epitop pancreat cancer tissu mass spectrometri identifi cell epitop pancreat ductal adenocarcinoma pdac associ antigen neoantigen challeng studi attempt identifi pdac cell epitop mass spectrometri ms
D018984;D010190
T129;T191
36,284,346
efficaci safeti carbon ion radiotherapi bone sarcoma systemat review meta analysi studi aim systemat evalu conduct meta analysi efficaci safeti carbon ion radiotherapi bone sarcoma
D063193;D012516;D002813;D012509;D001859
T061;T191
36,284,344
extracellular vesicl deriv endometri epitheli cell deliv exogen mir b p affect function embryon trophoblast cell via target tsc dkk extracellular vesicl ev could mediat embryo matern communic affect embryo implant deliv biolog inform includ microrna mirna protein lipid previous research show mir b p differenti express ev uterin flush fluid embryo implant period howev role mir b p ev embryo implant remain elus
D035683;D000067128
T026;T123;T114
36,284,343
postnat club integr postnat care johannesburg south africa qualit assess implement south africa report challeng retain women prevent mother child transmiss hiv pmtct program postnat due success pmtct antenat period proport infant transmiss occur deliveri mdecin san frontir msf postnat club pnc model allow integr postnat care support anova health institut implement model primari health facil johannesburg part plan nation scale aim assess implement pncs
D015658;D018445;D011251
T047;T046
36,284,342
effect differ temperatur carbohydr protein contain drink gastric empti rate exercis healthi young men random crossov trial present studi examin effect differ temperatur carbohydr protein contain drink exercis subsequ gastric empti rate healthi young men
D005746;D002245
T123;T197;T042
36,284,341
evalu urinari contin status influenc qualiti life gyneco oncolog treatment femal pelvic malign oncolog center urinari incontin ui could negat affect person qualiti life qol studi investig associ among gynecolog cancer treatment ui effect qol survivor gynecolog cancer cross section questionnair base studi includ case patient undergon gyneco oncolog therapi particip ask whether experienc form ui whether impact qol follow therapi use treat gynecolog tumor type found particip surgeri n chemotherapi ctx n radiotherapi rtx n antibodi therapi abt n signific associ determin tumor type ui howev bodi mass index bmi radic hysterectomi vulvar vagin surgeri presenc ui treatment signific impact presenc ui surgic access rout ctx abt hysterectomi signific impact sever ui treatment among patient report good qol report good qol patient could due good adjust situat regard diagnos receiv treatment cancer due patient consid ui much issu addit patient report inform risk ui treatment inform patient ui one risk therapi initi treatment crucial patient inform beforehand cope ui far better inform henc treatment ui often success patient encourag receiv urogynecolog consult
D010386;D014549
T191;T046
36,284,340
impact food consumpt biochem marker anthropometr variabl women metabol syndrom metabol syndrom met group diseas character insulin resist met high preval among women impact food intak met relat high level inflamm howev impact whole diet biochem anthropometr marker effect met need elucid case object studi assess relationship food intak biochem anthropometr marker women met
D024821;D061385
T121;T047
36,284,339
associ variant kifa gene amyotroph later sclerosi amyotroph later sclerosi al devast progress neurodegen diseas affect neuron central nervous system spinal cord mani neurodegen disord genet risk factor pathogenesi al involv dysregul cytoskeleton neuron transport notabl sensori motor neuron diseas hereditari sensori autonom neuropathi type hsan spastic paraplegia spg share sever causat gene al well common clinic phenotyp kifa encod kinesin motor transport presynapt vesicl precursor svps dens core vesicl report causat gene hsan spg
D000690;D019636;D015419;D009477
T047
36,284,338
patient satisfact surgic inform consent jimma medic center ethiopia inform consent process healthcar provid obtain permiss individu prior surgeri patient satisfact inform consent process one main indic healthcar servic qualiti studi aim assess patient satisfact surgic inform consent jimma medic center ethiopia
D017060;D006761
T073;T093;T080
36,284,336
machin learn algorithm identifi cluster random trial medlin embas cluster random trial crts becom increas import design howev author crts alway adher requir explicit identifi design cluster random titl abstract make retriev bibliograph databas difficult machin learn algorithm may improv identif retriev therefor aim develop machin learn algorithm accur determin whether bibliograph citat crt report
D000069550;D000465
T170;T066
36,284,335
promot equiti health emerg health system strengthen lesson learn disabl inclus covid pandem discriminatori health system inequ servic provis inevit creat barrier certain popul health emerg person disabl disproportion affect covid pandem common experi three increas risk contract diseas sever diseas death new worsen health condit ad risk occur due rang barrier health sector includ physic barrier prevent access health facil specif intervent inform barrier prevent access health inform andor reduc health literaci attitudin barrier give rise stigma exclus add discrimin inequ furthermor nation health emerg prepared plan may fail consid need prioriti person disabl divers thus leav behind respons commentari discuss import inclus health system strengthen prerequisit access comprehens health emerg prepared respons plan reach everyon lesson learn relat disabl inclus covid pandem inform health system strengthen recoveri effort address under barrier access inclus turn improv prepared futur health emerg
D000086382;D006233
T047;T101;T067
36,284,334
comparison continu versus intermitt enter feed critic ill patient systemat review meta analysi enter rout common utilis support nutrit requir critic ill patient howev pauciti data guid clinician regard appropri method deliv prescrib dose continu enter feed common use howev bolus intermitt method administr may provid sever advantag minimis interrupt purpos meta analysi compar continu versus intermitt bolus enter nutrit administr method
D004750;D016638
T061;T047;T074
36,284,333
influenc demograph socio econom factor choos hospitalist career among us medic student subspecialti hospit medicin hm grown rapid sinc mid divers inclus often studi context healthcar equiti leadership howev littl known factor potenti associ choos career path among us medic student
D013337;D020445
T097
36,284,331
immunogen efficaci safeti sar cov vaccin dose fraction systemat review meta analysi dose fraction coronavirus diseas covid vaccin could effect acceler global vaccin coverag support evid efficaci immunogen safeti unavail especi emerg variant
D000086382;D000086663
T200;T047;T067
36,284,330
genet epigenet regul catechol methyltransferas relat inflamm chronic fatigu syndrom fibromyalgia catechol methyltransferas comt shown influenc clinic pain descend modul exercis induc symptom worsen comt regul nocicept process inflamm key pathophysiolog featur chronic fatigu syndrom fibromyalgia cfsfm aim determin interact genet epigenet mechan regul comt influenc inflammatori marker symptom patient cfsfm
D005356;D015673
T047
36,284,329
role triglycerid predictor autoimmun hepat cirrhosi metabol relat indic suggest possibl prognost indic liver diseas recent relev studi valu predict autoimmun hepat aih cirrhosi unclear studi evalu role lipid level determin prognosi aih relat cirrhosi
D019693
T047
36,284,328
acut perchloroethylen intox elder woman case report perchloroethylen colorless strong smell substanc common use dri clean liver kidney toxic carcinogen well known occup hazard caus chronic perchloroethylen exposur acut intox ingest nondilut perchloroethylen rare adult popul owe strong smell tast data avail physician manag patient situat
D013750
T131;T109
36,284,327
joint model strategi use electron medic record data build machin learn model exampl intracerebr hemorrhag outlier class imbal medic data could affect accuraci machin learn model physician want appli predict model use data hand build model model choos thorni problem therefor necessari consid outlier imbalanc data model select paramet tune model
D057286;D000069550
T170;T073;T066
36,284,325
extraordinari make ordinari visibl nurs student experi learn clinic practic covid qualit studi covid crisi signific impact health care nurs educ larg part carri clinic practic howev known learn situat pandem affect student learn deepen understand student learn learn theori within construct paradigm use framework studi purpos studi explor nurs student percept learn clinic practic covid
D000086382;D004506;D004508;D013338
T065;T047;T097;T067
36,284,324
fall new routin factor influenc implement admiss discharg programm hospit general practic vespeera programm multifacet programm enhanc inform transfer general practic hospit across process hospit admiss stay discharg implement hospit general practic southern germani uptak heterogen overal low process evalu aim identifi factor associ implement vespeera programm
D010351;D058006
T058;T091
36,284,323
intervent time decid status autophagi nlrp activ apoptosi macrophag induc ox ldl determin extens studi autophagi nucleotid bind oligomer domain like receptor contain pyrin domain nlrp inflammasom apoptot respons macrophag joint contribut atherogenesi develop presenc lipid abnorm studi investig full scale intervent time lipid abnorm nlrp activ signific effect autophagi nlrp apoptot status macrophag
D058847;D050197
T123;T047;T046;T116
36,284,322
respons toshihid tsuda yumiko miyano eiji yamamoto august publish environment health toolkit detect misus epidemiolog method goal provid organiz framework transpar evalu epidemiolog studi bodi evid result conclus tsuda et al first group util toolkit systemat fashion offer suggest modif
D016021
T062
36,284,320
temperatur relat mortal associ vulner evid scotland use extend time seri dataset advers health impact found extrem temperatur mani part world major research date uk conduct popul england whilst impact ambient temperatur health outcom scottish popul remain larg unknown
D003080;D055874
T033;T070
36,284,319
econom impact implement prescript singl inhal tripl therapi versus current multipl inhal tripl therapi copd apulia region impact direct cost associ copd nation health system nhs relat access emerg room hospit admiss due onset one copd exacerb time sever copd treatment often requir combin medica repres substanti econom burden nation health system nhs studi aim evalu potenti save deriv implement prescript two current avail singl inhal tripl therapi sitt versus current use multipl inhal tripl therapi mitt elig copd popul resid apulia region
D018727;D029424
T121;T047
36,284,318
effect dabigatran versus warfarin year cognit outcom old patient atrial fibril result giraf random clinic trial observ studi support role oral anticoagul reduc risk dementia atrial fibril patient conclus data lack sinc dabigatran offer stabl anticoagul hypothes would reduc cognit declin compar warfarin old patient atrial fibril
D001281;D020521
T047;T046
36,284,317
readz detect cell type specif development regul rna process program singl cell rna seq rna process includ splice altern polyadenyl crucial gene function regul method detect rna process singl cell rna sequenc data limit relianc pre exist annot peak call heurist collaps measur cell type introduc readz annot free statist approach identifi regul rna process singl cell readz discov cell type specif rna process human lung conserv development regul rna process mammalian spermatogenesi includ global utr shorten human spermatogenesi readz also discov global utr lengthen arabidopsi develop highlight use method annot transcriptom
D026723;D059467
T081;T044;T086
36,284,314
neutrophil degranul sever impair extracellular trap format basi suscept infect hemodialysi patient chronic kidney diseas patient increas risk mortal cardiovascular diseas infect two lead caus death end stage kidney diseas treat hemodialysi hd mortal bacteri infect hd patient estim time higher healthi popul
D065206
T026
36,284,313
bgalt remodel tumor microenviron gd mediat lipid raft format c metaktmtorirf axi neuroblastoma beta galactosyltransferas bgalt play critic regulatori role tumor biolog howev role bgalt modul tumor microenviron tme neuroblastoma nb remain unknown
D009447;D051057
T191;T126;T116
36,284,312
dis advantag posit access gender affirm healthcar finland intersect qualit studi foreign origin transgend peopl increas bodi scholarship focus transgend individu experi access gender affirm healthcar howev experi transgend individu identifi foreign origin finland rare studi studi aim fill gap research contribut understand experi transgend individu also identifi belong foreign origin popul finland
D054242;D006297;D063106
T033;T098;T080
36,284,311
crispr krispr method identifi target random insert donor dnas character knock mice crispr tool generat knockout knock anim model easili model contain target genom lesion random insert donor dnas simpler method identifi target lesion random insert use tail earpiec dna unavail develop crispr krispr crispr knock in random insert search protocol method identifi target lesion random insert crispr krispr use littl g genom dna thus easili incorpor addit step genotyp founder anim breed
D064112;D064113
T040;T028;T114
36,284,310
laparoscopi assist abomas cannul cadav bovin fetus due complex rumin digest cannul organ digest tract carri order advanc understand digest physiolog nutrient degrad gastrointestin diseas biotechnolog research abomas cannul interest nutrit studi especi suckl calv obtain fluid abomas content evalu abomas flow function infus nutrient drug intend reach high concentr organ convent access cannul digest organ rumin perform laparotomi method often critic classifi cruel sector relat ethic anim welfar aim present studi describ standard minim invas laparoscopi assist abomas cannul bovin fetus cadav previous slaughter accid would discard local slaughterhous
D000018;D010535
T060;T023;T061
36,284,309
hpv infect mchmc epigenet marker penil squamous cell carcinoma new insight prognost penil cancer one aggress male tumor although prevent main etiolog caus lifestyl behavior viral infect human papillomavirus hpv long term epigenet chang due environment factor chang cell fate promot carcinogenesi import marker prognosi evalu epidemiolog aspect penil squamous cell carcinoma scc preval hpv infect use high risk hpv hrhpv p inka express particip global dna methyl evalu methylcytosin mc hydroxymethylcytosin hmc
D010412;D030361;D002294;D052685
T047;T191;T005
36,284,308
older peopl use public health servic integr age program multidimension approach qualit studi world popul age rapid huge amount servic provid meet need older peopl identifi factor affect non attend older peopl health care centr particular import focus reason older peopl use servic integr age program iran perspect older peopl general practition primari health provid
D000375;D058005
T033;T040;T097
36,284,307
adher evid base practic across healthcar profession germani result cross section nationwid survey adher evid base practic ebp consid key compet improv healthcar qualiti studi aim describ ebp adher healthcar profession work germani explor barrier facilit regard implement ebp clinic practic
D055317;D059825
T169;T091;T097
36,284,306
drug kras current perspect state art review decad effort recent made progress target kras mutat sever malign known holi grail target cancer therapi kras frequent mutat oncogen human malign normal condit kras shuttl gdp bound state gtp bound state mutant kras constitut activ lead persist downstream signal oncogenesi improv understand kras biolog newer drug design technolog led crucial discoveri cystein drug bind pocket gdp bound mutant kras gc protein coval inhibitor block mutant kras gc success develop sotorasib first kras gc inhibitor approv sever pipelin simultan effect kras mutat tumour microenviron also discov part owe univers use immun checkpoint inhibitor review discuss discoveri biolog function kras human malign also discuss relationship kras mutat tumour microenviron therapeut strategi target kras final review current clinic evid ongo clinic trial novel agent target kras shine light resist pathway known far
D000970;D009369
T121;T191;T109
36,284,305
autom measur malaria parasitaemia among asymptomat blood donor malawi use sysmex xn analys could data use complement nation malaria surveil real time recent worldwid increas malaria case highlight need renew effort elimin malaria world health organ advoc malaria surveil becom core intervent current method estim malaria burden reli clinic malaria case report survey asymptomat parasit infect main children year studi hypothesi screen blood donor malaria parasit would provid real time inform asymptomat reservoir parasit adult popul mirror surveil data
D016778;D008288
T047
36,284,304
structur development dynam matrix associ region drosophila melanogast genom eukaryot genom compartment structur function domain one concept higher order organ chromatin posit dna organ constrain loop behav independ function domain nuclear matrix numat ribo proteinac nucleoskeleton provid structur basi organ dna sequenc locat base loop known matrix attach region mar numat relat multipl nuclear process part cell type specif composit biochem defin structur sever protocol use isol numat step critic evalu sequenc play import role genom organ imper know dynam develop differenti
D004331;D006570
T026;T204
36,284,303
metformin allevi bone loss ovariectom mice inhibit autophagi osteoclast precursor mediat ef postmenopaus bone loss main caus excess bone resorpt mediat osteoclast becom global public health burden metformin hypoglycem drug report benefici effect maintain bone health howev role under mechan metformin ovariectom ovx induc bone loss still vagu
D015663;D008687;D001862
T121;T047;T042;T109
36,284,302
candid gene screen base phenotyp observ transcriptom analysi doubl flower prunus mume prunus mume earli spring flower rosacea own high applic valu garden excel ornament trait doubl flower trait alway one import breed goal plant breeder howev key regulatori gene doubl flower trait p mume still unclear present
D027861
T002
36,284,301
hb egf upregul star express stimul progesteron product erk signal human granulosa lutein cell heparin bind epiderm growth factor like growth factor hb egf belong epiderm growth factor egf famili growth factor hb egf receptor epiderm growth factor receptor egfr express human corpus luteum hb egf shown regul luteal function prevent cell apoptosi steroidogenesi primari function human corpus luteum steroidogen acut regulatori protein star play critic role steroidogenesi star express progesteron p product human granulosa lutein hgl cell shown upregul ligand egfr amphiregulin howev whether hb egf achiev effect remain unknown
D008184
T025
36,284,300
lncrna fendrr rna methyl regul hypoxia induc pulmonari arteri endotheli cell pyroptosi mediat drp dna methyl pyroptosi form program cell death involv pathophysiolog progress hypox pulmonari hypertens hph emerg evid suggest n methyladenosin modifi transcript long noncod rnas lncrnas import regul particip mani diseas howev whether modifi transcript lncrnas regul pyroptosi hph progress remain unexplor
D062085;D006976
T123;T046;T114
36,284,299
oral present assess imag read behaviour brain comput tomographi read novic clinic learner eye track studi studi whether oral present op assess could reflect novic learner interpret skill read behaviour brain comput tomographi ct read
D000084542;D013337
T060;T073;T097
36,284,298
develop valid infant facial skin assess tool prospect observ studi sever infant eczema face treat earli may lead allerg diseas futur howev caregiv find difficult assess visual tool caregiv need easili determin infant facial skin condit sever base tool score develop infant facial skin assess tool ifsat evalu reliabl valid
D017028
T099;T098;T097
36,284,297
earli predict patient discharg disposit acut neurolog care use machin learn acut neurolog complic lead caus death disabl us medic profession treat patient set task decid eg home facil discharg patient import abl predict potenti patient discharg outcom earli possibl patient hospit stay know factor influenc develop discharg plan studi carri two parallel experi multi class outcom patient discharg target home nurs facil rehab death binari class outcom home vs non home goal studi develop earli predict model experi explor patient characterist clinic variabl signific influenc discharg plan patient base data avail within h hospit admiss method methodolog center around build train five differ machin learn model follow test tune model find best suit predictor experi dataset adult patient neurolog condit taken eicu crd databas
D010351;D000069550
T058;T066
36,284,296
physician particip qualiti improv work interest opportun cross section survey lack physician involv qualiti improv threaten success sustain qualiti improv measur therefor import assess physician interest opportun involv qualiti improv experi particip hospit general practic
D010820;D058996
T097;T057