PMID
int64 35.7M
36.4M
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36,284,125
|
kuala machin learn driven framework kinas inhibitor reposit famili protein kinas compris gene involv numer function henc physiolog dysfunct pave way toward drug discoveri cancer cardiovascular inflammatori diseas matter fact kinas bind site high similar doubl role one hand critic issu select hand accord poli pharmacolog synergist control effect one target could great pharmacolog interest anoth import aspect bind similar possibl exploit reposit drug target famili studi propos approach call kinas drug machin learn framework kuala automat identifi kinas activ ligand use specif set molecular descriptor provid multi target prioriti score repurpos threshold suggest best repurpos non repurpos molecul comprehens list kinas ligand pair score found https githubcommolinfrimedmulti kinas
|
D058492;D055808
|
T062;T061
|
36,284,124
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weather impact interact nest bird nest dwell ectoparasit ant weather domin impact organ includ life histori interspecif interact yet nest bird arthropod inhabit bird nest direct cascad effect weather poor known explor influenc ambient temperatur rainfal cohabit dome shape bird nest wood warbler phylloscopus sibilatrix blowfli protocalliphora azurea ectoparasit predatori myrmica lasius ant may provid nest sanit sampl blowfli ant nest measur warbler nestl primev biaowiea forest eastern poland probabl ectoparasit occur nest increas increas ambient temperatur declin precipit earli nestl stage adult blowfli oviposit present number ectoparasit greater higher ambient temperatur prevail late nestl stage ant absent nest howev nestl growth unrel ectoparasit abund ant presenc within bird nest although lower high rainfal result suggest weather conflict impact interact nest bird nest dwell arthropod bird most compens relat cost old growth forest food general abund
|
D001000;D046109;D001181
|
T012;T204
|
36,284,123
|
effici raav vector protein express cortic parvalbumin express interneuron recombin adeno associ virus raav extens use research clinic applic despit signific advanc lack short promot abl drive express virus deliv gene specif class neuron design effici raav vector suitabl raav mediat gene express cortic interneuron main parvalbumin express cell vector includ short parvalbumin promot special poli sequenc degre conserv parvalbumin gene adjoin non code region use promot design select poli sequenc specif establish co local fluoresc virus deliv egfp antibodi neuron marker raav particl inject visual cortex area vv adult rat month old neuron express virus deliv egfp main posit interneuron marker parvalbumin somatostatin vasoact intestin peptid cholecystokinin meanwhil posit camkii marker princip cell cortex effici construct verifi optogenet experi express virus deliv chr channel suffici evok blue light laser high frequenc burst action potenti putat fast spike neuron conclud promot allow high specif express raav deliv cdnas cortic interneuron strong prefer parvalbumin posit cell
|
D010320;D014660
|
T125;T123;T116
|
36,284,122
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co alter circadian clock gene transcript human placenta preeclampsia pre eclampsia pe hypertens condit occur pregnanc complic pregnanc pe exhibit sever circadian relat characterist placenta possess function molecular clock examin associ core circadian gene transcript placenta pe vs non pe mixtur pregnant women term preterm small gestat age chorioamnion use two independ gene express dataset gse pe vs non pe gse pe non pe found robust differ circadian gene express pe non pe across two dataset cri mrna increas nrd per transcript decreas pe placenta gene set variat analysi reveal interplay co alter circadian clock gene pe alter hypoxia cell migrationinvas autophagi membran traffick pathway use human placent trophoblast htr cell show cri nrd regul trophoblast migrat subgroup studi includ term sampl demonstr clock nrd per transcript simultan decreas pe placenta find support clock protein downregul independ cohort human term pe placenta sampl find provid novel insight role molecular clock pathogenesi pe
|
D011225;D057906
|
T040;T046
|
36,284,120
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amelior effect oregano origanum vulgar versus silymarin experiment induc hepat encephalopathi hepat encephalopathi deterior brain function patient suffer chronic liver diseas cirrhosi result elev blood ammonia product pseudo neurotransmitt herein investig chemic composit hexan extract origanum vulgar vulgar leav well possibl protect effect thioacetamid taa induc rat gc ms analysi extract reveal tentat identif twenti five compound predomin cholesten one follow tocopherol tocopherol amyrin amyrin albino rat distribut seven group n g serv negat control g g serv control treat vulgar mgkgpo bw respect g serv taa posit control group mgkgdayip three altern day per week six week g g g serv taa induc rat model receiv vulgar vulgar silymarin mgkg sili standard drug respect taa show depress anxieti like behavior forc swim test fst reduct cognit score elev plus maze test epmt well impair locomotor exploratori activ open field test oft taa caus signific declin bodi weight gain howev relat liver weight brain water content statist increas taa intox rat show signific increas serum biomark enzym proinflammatori cytokin blood ammonia level brain serotonin acetyl cholinesteras cellular lipid peroxid signific decreas brain dopamin norepinephrin antioxid status hepatoprotectiveneuro protect activ vulgar found compar sili rat model treatment taa intox rat vulgar attenu anxieti depress relat behavior reduc biochem chang induc taa therefor vulgar could excel hepato neuroprotect hepat injuri via improv oxidativeinflammatori status antioxid neuro modulatori properti effect equal sili
|
D006501;D031341;D012838
|
T121;T109;T168;T047;T002
|
36,284,118
|
chang projectil design size prey reveal central role fishtail point megafauna hunt south america fishtail projectil point earliest widespread projectil type south america share chronolog techno morpholog clovi oldest north american projectil type tempor associ late pleistocen megafaun extinct although elus direct evid human exploit megafauna south america kept fishtail extinct debat recent paper show strong relationship tempor densiti spatial distribut megafauna fishtail projectil point propos weapon design use megafauna hunt contribut extinct technolog must distinct differ post fpp technolog ie earli holocen projectil point use hunt smaller prey term distribut function properti paper explor chang projectil point technolog well bodi mass potenti megafaun prey show fishtail strong relat largest extinct megafaun speci
|
D053476;D000090262
|
T056;T070
|
36,284,117
|
ramucirumab combin sorafenib enhanc inhibitori effect sorafenib hepg cancer cell sorafenib oral multipl kinas inhibitor standard treatment hepatocellular carcinoma hcc one strategi improv hcc therapi combin agent target key signal pathway studi set investig effect combin sorafenib either bevacizumab anti vegf panitumumab anti egfr ramucirumab anti vegfr hepg cancer cell line aim improv efficaci possibl therapeut dose reduct sorafenib hepg cancer cell line treat sorafenib alon combin either bevacizumab panitumumab ramucirumab cell prolifer apoptosi cell cycl distribut gene express vegfr egfr mmp caspas protein level pvegfr pstat protein express caspas egfr vegfr determin combin treatment sorafenib ramucirumab panitumumab result signific decreas sorafenib ic sorafenib combin ramucirumab bevacizumab result signific arrest pre g gg cell cycl phase signific induc apoptosi increas relat express caspas decreas anti prolif angiogenesi marker mmp pvegfr vegfr hepg cell signific decreas level pstat detect case sorafenib ramucirumab combin combin treatment sorafenib panitumumab induc signific arrest pre g gm cell cycl phase signific decreas relat express egfr mmp sorafenib ramucirumab combin show enhanc apoptosi inhibit prolifer angiogenesi hepg cancer cell find suggest ramucirumab use adjunct therapi improv sorafenib efficaci suppress hcc
|
D006528;D008113;D000970
|
T121;T191;T109
|
36,284,116
|
tempor pattern function anti dengu antibodi dengu infect individu differ diseas outcom infect histori heterotyp secondari dengu virus denv infect risk factor develop sever diseas assess contribut develop polyclon humor immun respons cours acut infect determin anti denv igg titer neutral antibodi percentag antibodi bind denv infect cell antibodydepend enhanc ade infect serotyp denv infect cambodian children n rang asymptomat dengu sever diseas result show ade titer highest infect serotyp heterotyp secondari denv infect moreov igg titer neutral antibodi ade titer infect serotyp peak maintain laboratori confirm secondari denv infect anti denv igg titer magnitud function antibodi respons higher secondari denv infect patient compar primari infect patient differ antibodi titer neutral enhanc antibodi could observ asymptomat hospit patient day laboratori confirm denv infect howev time point level igg bound denv infect cell associ diseas sever hospit patient taken togeth data offer insight comprehens interpret antibodi respons profil natur infect correl diseas outcom
|
D003716;D060085
|
T005;T047
|
36,284,115
|
excess dietari linol acid promot plasma accumul pronocicept fatti acyl lipid mediat various fatti acyl lipid mediat deriv dietari polyunsatur fatti acid pufa modul nocicept modern diet rich linol acid associ nocicept hypersensit may present risk factor develop pain condit although recommend fatti acid intak exist diseas eg cardiovascular diseas role dietari fatti acid promot pain disord complet understood determin dietari linol acid content influenc accumul pro anti nocicept fatti acyl lipid mediat creat novel rodent diet use custom triglycerid blend rich either linol acid oleic acid quantifi fatti acyl lipidom plasma male femal rat fed custom diet time wean nine week age dietari fatti acid composit determin circul plasma fatti acyl lipidom content exposur diet rich linol acid associ accumul linol arachidon acid deriv pro nocicept lipid mediat reduct anti nocicept lipid mediat deriv omega pufa find provid mechanist insight exagger nocicept hypersensit associ excess dietari linol acid intak highlight potenti biomark pain risk stratif
|
D019787;D015777
|
T123;T121;T109
|
36,284,114
|
low cost adapt option support green growth agricultur water resourc coastal zone region climat futur put pressur invest sub saharan africa water resourc manag fisheri crop livestock product system chang ocean characterist across atlant ocean result remark vulner coastal ecolog littor mangrov middl twenti first centuri beyond line countri object creat green economi allow reduc greenhous gas emiss improv resourc effici prevent biodivers loss identifi press need adapt best adapt choic also clean afford accord empir data field custom model simul design cost adapt measur like decreas benefit sustain green growth agricultur water resourc manag coastal ecosystem hydroclimat hazard pluviometr thermal extrem becom common west africa adapt option local need scale operation sustain develop government sovereign wealth fund invest privat sector fund global climat fund use operation adapt measur effect legisl knowledg transfer pertin collabor necessari success
|
D017753;D000074382
|
T197;T070;T082
|
36,284,112
|
natur colon wash fecal sampl two side coin investig human gut microbiom date sever studi address import role gut microbiom interplay human host health diseas status howev select univers sampl matrix repres microbi biodivers associ gastrointestin gi tract still challeng present studi deep metabarcod analysi rrna gene compar two sampl matric fece f colon wash fece cwf order evalu relat effect accuraci repres complex human gut microbiom cohort volunt recruit pair f cwf sampl collect subject alpha divers analysi confirm slight higher biodivers cwf compar f match sampl likewis beta divers analysi prove pair f cwf microbiom quit similar individu remark inter individu variabl occur among microbiom particip taxonom analysi match sampl carri investig intra inter individu variabl firmicut bacteroidota proteobacteria actinobacteriota main phyla f cwf sampl genus level bacteirodet abund f cwf sampl follow faecalibacterium blautia escherichia shigella studi highlight inter individu variabl greater intra individu variabl pair f cwf sampl inde overal higher similar observ across match f cwf sampl suggest expect remark overlap microbiom infer use match f cwf sampl notabl absolut quantif total rdna droplet digit pcr ddpcr reveal compar overal microbi load pair f cwf sampl report first compar studi fecal colon wash fecal sampl investig human gut microbiom show type sampl may use equal studi gut microbiom present result suggest combin use type sampl matric could repres suitabl choic obtain complet overview human gut microbiota address differ biolog clinic question
|
D000069196;D064307
|
T032;T007;T028;T001
|
36,284,111
|
effect carbon monoxid nitrogen dioxid fine particul matter insect abund divers urban green space impact three air pollut carbon monoxid nitrogen dioxid fine particul matter pm divers abund insect fauna associ chines thuja platycladus orientali evalu first time iran sampl perform lashkar sadaf sajjad three urban green space mashhad citi locat razavi khorasan provinc total insect speci includ natur enemi herbivor identifi result indic herbivor abund posit signific correl level carbon monoxid nitrogen dioxid level fine particul matter contrast herbivor divers negat signific correl level carbon monoxid natur enemi abund divers signific correl level none three pollut aphid cinara thujafilina del guercio domin herbivor speci sampl site relat abund lashkar sadaf sajjad regard natur enemi ladybird coccinella septempunctata abund speci lashkar sadaf ladybird oenopia conglubata abund sajjad highest divers herbivor natur enemi across four season lashkar sadaf site result highlight three air pollut carbon monoxid one affect abund divers herbivor guild associ platycladus orientali urban green space
|
D000393;D000397
|
T131;T069;T080
|
36,284,108
|
cell specif bioorthogon tag glycoprotein alter glycoprotein express undisput corollari cancer develop understand alter paramount hamper limit under cellular model system instanc intric interact tumour host adequ recapitul monocultur tumour deriv cell line complex co cultur model usual reli sort procedur proteom analys rare captur detail protein glycosyl report strategi term bio orthogon cell line specif tag glycoprotein boctag cell equip transfect artifici biosynthet pathway transform bioorthogon tag sugar correspond nucleotid sugar transfect cell incorpor bioorthogon tag glycoprotein presenc non transfect cell employ boctag imag techniqu annot cell specif glycosyl site mass spectrometri glycoproteom demonstr applic co cultur mous model allow profil glycoproteom import modul cellular function
|
D020543;D040901
|
T123;T091;T116
|
36,284,107
|
salienc memori form valu novelti avers joint shape object respons prefront cortex basal ganglia ecolog fit depend maintain object histori guid futur interact recent evid show valu memori chang passiv visual respons object ventrolater prefront cortex vlpfc substantia nigra reticulata snr howev known whether effect limit reward histori cross domain represent organ within differ neural popul corticobas circuitri address issu visual respons neuron across appetit avers novelti domain record vlpfc snr result show chang visual respons across domain happen rather separ popul relat salienc rather valenc object furthermor snr preferenti encod outcom relat salienc memori vlpfc encod salienc memori across domain correl fashion consist role inform hub guid behavior
|
D001479;D017397
|
T023;T029;T030
|
36,284,106
|
transplant human adipos deriv stem cell overexpress lififn promot recoveri experiment autoimmun encephalomyel eae multipl sclerosi ms common demyelin diseas inflammatori demyelin central nerv system besid defect myelin repair process balanc chang inflammatori anti inflammatori cytokin one signific factor ms pathogenesi studi aim evalu effect co overexpress beta interferon ifn leukemia inhibitori factor lif human adipos deriv stem cell ifn lif hadsc experiment autoimmun encephalomyel eae day induct eae femal mice cbl mog emerg primari clinic sign ifn lif hadsc inject mice tail vein eae mice mice sacrif day spinal cord experiment group dissect histopatholog real time rt pcr studi show clinic score infiltr mononuclear cell treat mice ifn lif hadsc decreas signific demyelin number olig mbp cell signific increas test ifn lif hadsc group find reveal pattern inflammatori anti inflammatori cytokin gene express ifn lif hadsc group revers compar control group overexpress lif neurotroph ifn anti inflammatori cytokin hadsc increas immunomodulatori effect hadsc reduc extent demyelin improv number olig cell also increas amount mbp protein increas product myelin eae model besid hadsc capac prolifer differenti might enhanc treatment efficaci provid promis candid stem cell base gene therapi ms therapi futur
|
D004681;D009103
|
T047;T050
|
36,284,105
|
task depend fractal pattern inform process work memori appli detrend fluctuat analysi power spectral densiti eigenanalysi detrend cross correl investig fmri data repres diurnal variat work memori four visual task two verbal two nonverb show degre fractal scale region depend engag cognit task particular appar differ found memoris verbal nonverb task furthermor detrend cross correl brain area predomin indic differ rest state task memoris retriev verbal nonverb task fractal spectral analys present studi consist previous research relat visuospati verbal inform process work memori encod retriev execut function found sensit pearson correl show potenti obtain subtler result conclud region depend cognit task engag distinguish base fractal characterist bold signal detrend cross correl structur
|
D008570;D017709
|
T077;T041
|
36,284,104
|
tandem duplic genom region encod glutathion transferas epsilon gene ddt resist anophel stephensi strain india glutathion transferas gst gene multigen famili enzym involv metabol endogen xenobiot compound catalys conjug reduc form glutathion substrat epsilon class gst gste uniqu arthropod known involv detoxif process sever class insecticid gste particular known ddt dehydrochlorinas activ communic report tandem duplic genom region encod gste gste gene laboratori colon ddt resist anophel stephensi identifi duplic breakpoint organ gene duplic sanger sequenc perform long pcr product manual annot sequenc reveal tandem array duplic kb segment gst epsilon gene cluster compris five gene partial gste gste gste pseudogen gste partial gste interconnect conserv kb dna insert segment major part homolog genom region locat differ chromosom tandem duplic array contain total two gste three gste function paralog gene read depth coverag split read analysi illumina base whole genom sequenc read confirm presenc duplic correspond region genom increas gene dose mosquito result gste gene duplic may adapt process increas level detoxifi enzym counter insecticid pressur
|
D000852;D007306
|
T131;T204
|
36,284,103
|
preval factor relat hypouricemia hyperuricemia schoolchildren result larg scale cross section popul base studi conduct japan hypouricemia children includ renal hypouricemia major caus exercis induc acut renal injuri eiaki import clinic problem addit hyperuricemia howev larg scale studi serum uric acid ua concentr general pre adolesc popul carri conduct popul base cross section studi measur preval hypouricemia hyperuricemia identifi associ factor analyz boy girl year old children underw pediatr health check up kagawa prefectur hypouricemia hyperuricemia defin use serum ua concentr mgdl mgdl respect preval hypouricemia year old boy girl signific associ age sex environment factor includ overweight preval hyperuricemia signific higher boy girl signific associ age overweight futur diabet risk hypertriglyceridemia low high densiti lipoprotein cholesterol liver damag high low densiti lipoprotein cholesterol therefor pre adolesc children general popul japan show hypouricemia mean identifi children hypouricemia lifestyl guidanc measur prevent eiaki establish
|
D033461;D000137
|
T033;T047
|
36,284,099
|
termin unfold protein respons guid er stress induc hac mrna nuclear retent cellular homeostasi maintain surveil mechan interven virtual everi step gene express nucleus yeast chromatin remodel isw hold back matur mrna ribonucleoparticl prevent untim export whether activ oper beyond qualiti control mrna biogenesi regul gene express unknown identifi mrna encod central effector unfold protein respons upr hac isw rna target direct bind isw untransl region hac mrna restrict nuclear export requir accur upr abat accord isw inactiv sensit cell endoplasm reticulum er stress overexpress reduc upr induct result reveal unsuspect mechan bind er stress induc isw hac mrna limit nuclear export provid feedback loop fine tune upr attenu guarante homeostat adapt er stress
|
D029701
|
T116
|
36,284,097
|
binari fret reveal transient excit state structur associ activ depend camkii nrb bind adapt synapt function mediat modul coordin choreographi protein conform chang interact respons intracellular calcium dynam time laps frster reson energi transfer use studi dynam conform chang protein protein interact simultan physiolog condit two reson energi transfer reaction multiplex binari fret techniqu develop independ monitor dynam calcium calmodulin depend protein kinas ii catalyt domain pair separ holoenzym role establish activ depend holoenzym affin nrb bind fragment n methyl aspart receptor show transient excit state intermedi exist pair catalyt domain holoenzym first separ prior subsequ nrb associ addit non satur free calcium concentr multiplex approach reveal holoenzym exhibit biochem form plastic calcium depend adapt site ligand bind affin
|
D054732;D016194
|
T126;T116;T192
|
36,284,096
|
subcellular local type iv pili regul bacteri multicellular develop mammal subcellular protein local factor like planar cell polar protein key driver multicellular organ tissu bacteria also form organ multicellular communiti pattern larg thought emerg regul whole cell process like growth motil cell shape differenti show uniqu intracellular pattern appendag known type iv pili tp drive multicellular develop complex bacteri communiti specif dynam tp appendag local line along long axi cell bacterium acinetobact baylyi long axi local regul function diverg chemosensori pil chp system atyp tp protein homologu fimv bridg pil chp signal tp posit demonstr model empir approach subcellular tp local control individu cell interact one anoth independ tp dynam differ pattern local give rise distinct multicellular architectur result reveal subcellular pattern singl cell regul develop multicellular bacteri communiti
|
D036781;D011550
|
T123;T007;T116
|
36,284,094
|
global mortal snakebit envenom snakebit envenom import caus prevent death world health organ set goal halv snakebit mortal use verbal autopsi vital registr data model proport venom anim death due snake locat age year sex appli proport venom anim contact mortal estim global burden diseas studi peopl uncertainti interv die global snakebit equal age standard mortal rate asmr death per repres decreas asmr sinc india greatest number death equal asmr per forecast mortal continu declin suffici meet goal improv data collect priorit help target intervent improv burden estim monitor progress
|
D012909
|
T037
|
36,284,093
|
intestin specif remov daf near doubl lifespan caenorhabd elegan littl fit cost twenti nine year follow breakthrough discoveri singl gene mutat daf doubl caenorhabd elegan lifespan remain unclear insulinigf receptor gene express act regul age use knock fluoresc report determin daf downstream transcript factor daf express ubiquit use tissu specif target protein degrad determin intracellular daf daf signal intestin play major role lifespan regul hypodermi neuron germlin play minor role notabl intestin specif loss daf activ daf outsid intestin caus almost advers effect develop reproduct extend lifespan way part requir non intestin daf consist intestin suppli nutrient entir bodi evid studi suggest alter metabol particular regul protein rna synthesi mediat longev reduct insulinigf signal
|
D017173;D029742
|
T116;T204
|
36,284,092
|
common evolutionari origin acoust communic choanat vertebr acoust communic broad distribut along vertebr phylogeni play fundament role parent care mate attract various behaviour despit import compar less known evolutionari root acoust communic phylogenet compar analys provid insight deep time evolutionari origin acoust communic often plagu miss data key speci present evid speci four major clade turtl tuatara caecilian lungfish form vocal record contextu behaviour inform accompani sound product broad literatur base dataset evid acoust abil sever group previous consid non vocal critic phylogenet analys encompass speci choanat vertebr reconstruct acoust communic homolog trait suggest least old last common ancestor choanat vertebr live approx million year present
|
D014714;D005075
|
T045;T010
|
36,284,091
|
e cigarett lone constitu induc cardiac arrhythmia conduct defect mice e cigarett use surg long term health effect remain unknown e cigarett aerosol contain nicotin acrolein combust e cigarett byproduct may impair cardiac electrophysiolog autonom imbal show mous electrocardiogram acut inhal e cigarett aerosol disturb cardiac conduct part parasympathet modul demonstr similar acrolein combust cigarett smoke aerosol e cigarett solvent veget glycerin propylen glycol induc bradycardia bradyarrhythmia elev heart rate variabl inhal exposur invers post exposur effect effect slighter tobacco menthol flavor aerosol contain nicotin femal mice yet menthol flavor pg aerosol also increas ventricular arrhythmia augment earli ventricular repolar j amplitud menthol uniqu alter atrial atrioventricular conduct exposur e cigarett aerosol veget glycerin byproduct acrolein diminish heart rate earli repolar pro arrhythm effect solvent aerosol ventricular repolar heart rate variabl depend part parasympathet modul wherea ventricular arrhythmia posit associ earli repolar depend presenc nicotin studi indic chemic constitu e cigarett could contribut cardiac risk provok pro arrhythm chang stimul autonom reflex
|
D066300
|
T073
|
36,284,088
|
loss thyroid gland circadian per rhythmic age mice potenti associ thyroid cancer develop molecular clock oper peripher tissu includ endocrin gland play import regulatori role context howev potenti age relat chang express rhythmic clock gene effect chang thyroid gland remain unknown present studi evalu express rhythmic peripher thyroid clock gene age mice use rna seq transcriptom analysi young month versus age month mice addit determin cellular effect silenc per major clock gene regul human thyroid cell line kyoto encyclopedia gene genom kegg pathway enrich analysi reveal differenti express gene deg thyroid gland age mice involv mitogen activ protein kinas mapk signal chemokin signal circadian entrain pikakt signal apelin signal express circadian clock gene arntlbmal signific downregul thyroid gland age mice wherea express gene involv regul cell prolifer migrat tumorigenesi upregul peripher thyroid clock gene particular per mrna per protein downregul thyroid gland age mice circadian oscil gene declin knockdown circadian clock gene per human thyroid follicular cell induc ap activ via jnk mapk signal activ increas cell prolifer furthermor age relat loss per circadian oscil activ ap transcript factor via jnk mapk pathway could contribut thyroid hyperplasia common age relat condit
|
D056930;D013964
|
T123;T191;T116
|
36,284,087
|
cancer associ fibroblast pancreat ductal adenocarcinoma pancreat ductal adenocarcinoma pdac lethal cancer promin extracellular matrix ecm deposit poor prognosi high level ecm protein deriv tumour cell reduc efficaci convent cancer treatment paradigm contribut tumour progress metastasi abund tumour promot cell ecm cancer associ fibroblast caf promis target novel anti tumour intervent nonetheless relat clinic trial hamper lack specif marker elus differ caf subtyp review origin function divers caf show creat tumour promot milieu focus crosstalk caf tumour cell immun cell tumour microenviron furthermor relev clinic advanc potenti therapeut strategi relat caf discuss
|
D000072645;D021441;D010190
|
T191;T025
|
36,284,081
|
systemat review current evid randomis control trial impact medic optimis pharmacolog intervent quantit measur cognit function geriatr patient cognit declin common older peopl numer studi point detriment impact polypharmaci inappropri medic older peopl cognit function aim systemat review evid impact medic optimis drug intervent cognit function older adult
|
D060825;D014150
|
T121;T039;T048
|
36,284,070
|
inquiri psycholog discuss danish academ situat szulevicz lund lund address three question academ train psycholog research danish master student psycholog frequent choos qualit method research b psycholog student work c interest three question led us reflect research train polit educ model univers adopt psycholog master cours danish context also general context commentari discuss one strict normat issu scientif ideal train research psycholog accur psycholog contribut discuss scientif ideal research train knowledg area
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D013334
|
T081;T098
|
36,284,036
|
improv predict character blood brain barrier penetr peptid use estim propens score dipeptid blood brain barrier bbb primari barrier high select semiperm border blood vascular endotheli cell central nervous system sinc bbb prevent drug circul blood cross interstiti fluid brain neuron resid mani research work hard develop drug deliveri system penetr bbb current pose challeng thus blood brain barrier penetr peptid bpps altern neurotherapeut brain relat disord sinc facilit drug deliveri brain meanwhil develop comput method effect identif character bpps cost effect manner play import role basic reach pharmaceut industri even though comput method bpp identif develop perform might fail term general abil interpret studi novel effici score card method base predictor term scmbpp present improv bpp identif character overcom limit black box comput approach scmbpp predictor automat estim amino acid dipeptid propens bpps cross valid independ test indic scmbpp achiev impress perform outperform various popular machin learn base method exist method multipl independ test dataset furthermor scmbpp deriv amino acid propens util identifi inform biophys biochem properti character bpps final onlin user friend web server http pmlabstackpythonanywherecomscmbpp establish identifi novel potenti bpp cost effect novel comput approach anticip facilit larg scale identif high potenti bpp candid follow experiment valid
|
D001812;D004151
|
T023;T116
|
36,284,028
|
point care ultrasound head neck region point care ultrasound pocus head neck region play particular signific role diagnosi treatment upper airway stenosi swell pain diseas neck evalu swallow function therefor perform various medic set beyond boundari clinic depart general medicin emerg medicin anesthesiolog orthoped pediatr target diseas salivari gland diseas lymph node diseas pharyng diseas laryng diseas esophag diseas thyroid diseas dysphagia dyspnea due various caus head neck pocus extrem use diagnost method patient doctor use expect becom widespread futur
|
D019095;D009333
|
T058;T029
|
36,284,026
|
methyl promot region brca gene versus pathogen variant gene risk factor clinic marker breast cancer studi compar contribut pathogen variant brca gene insc delag delt dela tg hypermethyl brca gene promot region risk breast cancer clinic featur women
|
D019398;D001943
|
T191;T028
|
36,284,019
|
situ electrodeposit cu bdc metal organ framework pencil graphit substrat solid phase microextract pesticid studi focus electrochem deposit copper benzen dicarboxyl framework cu bdc mof surfac cheap pencil graphit pg substrat util sorbent fiber solid phase microextract spme two chosen pesticid includ abamectin amitraz first time extract pesticid quantifi high perform liquid chromatographi ultraviolet detect hplc uv uv detector set nm wavelength base optim condit present techniqu show good linear rang g l g l suitabl limit detect lod g l satisfactori enhanc factor ef good absolut recoveri ar spike recoveri rang amitraz abamectin respect intra inter day relat standard deviat found within rang respect method success employ quantif select pesticid strawberri juic lemon juic orang juic tomato juic honey
|
D006108;D010575;D000073396
|
T131;T196;T109
|
36,284,011
|
basal gp depend mitophagi promot mitochondri health limit mitochondri ros mitochondria major sourc cytotox reactiv oxygen speci ros superoxid hydrogen peroxid uncontrol contribut cancer progress maintain fine tune healthi mitochondri popul essenti cellular homeostasi surviv mitophagi select elimin mitochondria autophagi monitor maintain mitochondri health integr elimin damag ros produc mitochondria howev mechan under mitophag control mitochondri homeostasi basal condit remain poor understood e ubiquitin ligas gp endoplasm reticulum membran protein induc mitochondri fission mitophagi depolar mitochondria report crisprca knockout gp ht fibrosarcoma cell increas mitochondri volum elev ros product render cell resist carbonyl cyanid chlorophenyl hydrazon cccp induc mitophagi effect phenocopi knockdown essenti autophagi protein atg wild type ht cell use mito keima mitophagi probe confirm gp promot basal damag induc mitophagi applic spot detect algorithm specht gfp mrfp tandem fluoresc tag lc tflc posit autophagosom report elev autophagosom matur wild type ht cell relat gp knockout cell predomin proxim mitochondria mitophagi inhibit either gp knockout atg knockdown reduc mitochondri potenti increas mitochondri ros live cell analysi tflc ht cell show preferenti associ autophagosom mitochondria reduc potenti xenograft tumor ht knockout cell show increas label mitochondria cell prolifer marker ki reduc label tunel cell death report basal gp depend mitophag flux therefor select associ reduc potenti mitochondria promot mainten healthi mitochondri popul limit ros product tumor cell prolifer
|
D063306;D013481
|
T121;T109;T043
|
36,284,003
|
determin diflufenican azaconazol pesticid wastewat sampl gc ms preconcentr stearic acid function magnet nanoparticl base dispers solid phase extract studi present preconcentr diflufenican azaconazol domest wastewat sampl use dispers solid phase extract dspe determin gas chromatographi mass spectrometri gc ms stearic acid coat magnet nanoparticl use adsorb dspe method order maxim effici extract process paramet magnet nanoparticl mnp type amount eluent type volum mix type mix period optim linear rang obtain azaconazol diflufenican ngml ngml limit detectionquantif lodloq calcul ngml ngml respect compar lod valu direct gc ms develop dspe method azaconazol diflufenican record approxim fold enhanc detect power recoveri experi domest wastewat carri certifi propos method accuraci applic use matrix match calibr strategi good percent recoveri result obtain
|
D010575;D058185
|
T131;T130
|
36,284,001
|
reusabl molecular imprint electrochemiluminesc assay kanamycin base order mesopor carbon load indium oxid nanoparticl carbon quantum dot high sensit kanamycin electrochemiluminesc ecl switch sensor construct signal element consist order mesopor carbon load indium oxid nanoparticlescarbon quantum dot omcin c dot assembl surfac gold electrod molecular imprint polym mip prepar modifi electrod surfac use kanamycin templat molecul aminophenol function monom kanamycin elut prepar sensor retain specif kanamycin recognit site omcin effect amplifi ecl signal c dot therebi enhanc detect sensit wherea kanamycin quench signal therefor imprint site act switch provid new method detect kanamycin optim experiment condit concentr kanamycin proport degre ecl quench within linear rang mol l v vs agagcl electrod electrod detect limit mol l appli detect kanamycin actual sampl chicken duck pork milk recoveri spike sampl rang
|
D045663;D054802;D053758
|
T063;T073
|
36,283,999
|
human astrocyt neurotrop flavivirus increas autophagi yet replic autophagi independ astrocyt abund type glial cell key cell provid homeostasi central nervous system due suscept infect combin high resili virus induc cell death astrocyt consid one princip type cell respons virus retent dissemin within brain autophagi play import role elimin intracellular compon maintain cellular homeostasi also intertwin life cycl virus physiolog signific autophagi astrocyt connect life cycl transmiss virus remain poor investig present studi investig flavivirus induc modul autophagi human astrocyt monitor tandem fluoresc tag lc probe mrfp egfp lc confoc super resolut fluoresc microscopi astrocyt infect tick born enceph virus tbev west nile virus wnv pathogen flavivirus mosquito flavivirus mof consid non pathogen result reveal human astrocyt suscept infect tbev wnv much lower extent also mof infect replic rate tbev wnv parallel increas rate autophagi wherea autophagosom matur size autophag compart affect modul autophagi rapamycin wortmannin influenc tbev wnv replic rate wherea bafilomycin attenu replic infect human astrocyt infect mof low infect lack effici replic flavivirus mirror absenc autophag respons
|
D001253;D004669
|
T005;T025
|
36,283,994
|
lymph node metastasi colorect cancer high risk histolog submucos invas depth number patient undergo addit surgeri endoscop resect er colorect cancer crc increas regard high risk histolog lymph node metastasi lnm crc submucos invas depth tb alon may relat low incid lnm studi conduct clarifi incid lnm identifi factor associ lnm crc high risk histolog character tb
|
D015179;D000230
|
T191
|
36,283,989
|
mycobacterium tuberculosi exploit mpt generat myeloid deriv suppressor cell evad immun system mycobacterium tuberculosi mtb smart success pathogen sinc persist intimid environ host tame tune immun system mtb releas mpt rvc protein high amount patient activ tuberculosi tb consequ curious deciph role mpt differenti dendrit cell dcs relat evad immun system observ pre exposur differenti dcs mpt dc mpt transform phenotyp myeloid deriv suppressor cell mdscs dc mpt express high level immunosuppress molecul pd l tim nitric oxid arginas ido il tgf inhibit product pro inflammatori cytokin tnf il il dc mpt chemotaxi function diminish due reduc express ccr dc mpt promot generat regulatori cell treg inhibit differenti th cell th cell high lipid methylglyox content reduc glucos consumpt dc mpt render metabol quiescent consequ reduc dc mpt abil phagocytos mtb provid safer shelter intracellular surviv mycobacterium mechan identifi impair function dc mpt increas product accumul methylglyox henc first time demonstr novel role mpt promot generat mdscs favor mtb surviv escap destruct immun system
|
D009169;D000072737
|
T007;T025
|
36,283,984
|
hydrophob determin bacteri kill rate helic antimicrobi peptid influenc bacteri resist develop rapid antimicrobi action import advantag antimicrobi peptid amp antibiot also reason amp less like induc bacteri resist howev structur paramet under mechan affect bacteri kill rate amp remain unknown studi perform structur activ relationship sar studi use cath templat reveal hydrophob rather characterist critic structur paramet determin bacteri kill rate helic amp hydrophob increas action rate amp includ bacteri bind lipopolysaccharid neutral outer inner membran permeabil increas addit higher hydrophob amp enhanc bacteri kill rate possess better vivo therapeut potenc lower propens induc bacteri resist find reveal import bacteri kill rate amp great signific design optim amp relat drug
|
D023181;D000089882
|
T129;T123;T121;T116
|
36,283,983
|
absorpt distribut metabol excret c mefuparib cvl novel parp inhibitor rat mefuparib cvl novel second generat poli adp ribos polymeras parp inhibitor cancer treatment cvl easili enter brain howev transport mechan cvl cross blood brain barrier bbb unknown
|
D001646
|
T047;T031
|
36,283,971
|
repli correspond synergi antagon alloster activ site inhibitor abl tyrosin kinas manley co worker provid data demonstr super pharmacolog concentr ternari complex abl asciminib atp competit inhibitor possibl work manuscript concern interplay asciminib gnf atp competit inhibitor pharmacolog relev concentr c max asciminib manley co worker question studi report provid explan work fit prefer model herein consid data present manley co worker addit provid new data support find communic asciminib atp competit inhibitor simultan bind abl pharmacolog relev concentr unless conform select ligand match
|
D019008;D016315
|
T126;T116;T038;T042
|
36,283,833
|
influenc cn orient degre electron deloc ru ru ru mix valent complex investig mix valent complex class iiclass iii frontier particular interest issu due special electron deloc work pair cyanidomet isocyanidomet bridg ru ru ru compound cis cp dppe ru b ru dppe cp b ncru bpi cn b cnru bpi nc cp cyclopentadienyl dppe bis diphenlyphosphin ethan bpi bipyridin one electron oxid synthes well character two electron oxid fourier transform infrar ftir uv vis nir spectra investig employ spectroelectrochem method time depend densiti function theori tddft calcul experiment result indic one two electron oxid mix valent compound belong class ii iii system
|
D012428
|
T196
|
36,283,825
|
differenti diagnosi back pain back pain bp among common reason seek medic attent worldwid natur bp depend causat stimulus anatom locat clinic bp manifest pain muscl tension stiff develop bp complex multifactori process somat stimuli anatom structur also psychosoci effect involv use varieti criteria bp divid specif caus pain known nonspecif wherein caus remain unclear accord durat ie acut subacut chronic back pain simpl low back pain must distinguish inflammatori bp inflammatori bp one symptom spondyloarthritid typic rest pain insidi onset peak night morn associ morn stiff improv exercis respond non steroid antirheumat drug red flag system develop earli identif risk patient potenti sever diseas present bp earli diagnosi identif caus complaint often requir multidisciplinari cooper treatment involv pharmacolog agent analges muscl relax therapi nonpharmacolog approach rehabilit surgic intervent etc
|
D025241;D018501
|
T121;T047
|
36,283,824
|
what new esc guidelin manag acut coronari syndrom patient present without persist st segment elev articl sumar esc guidelin manag acut coronari syndrom ac patient present without persist st segment elev diagnost ac consist assess chest pain ekg cardiac troponin troponin evalu high sensit assay hh algorithm use rule rule ac patient posit troponin higher risk cardivascular event mortal earli invas treatment appli patient guidelin sever antithrombot stretegi differ clinic condit mention cornerston length intens antithrombot treatment evalu bleed risk revascular aspect strategi debat guidelin final mention two specif condit ac myocardio infarct non obstruct coronari arteri spontan coronari arteri dissect
|
D054058
|
T047
|
36,283,823
|
time rang new paramet evalu blood glucos control continu glucos monitor becam common everyday clinic practic new paramet creat standard assess degre control peopl diabet use clear glycat haemoglobin new paramet time rang repres signific benefit diabetologist also import tool help patient daili live diabet
|
D015190;D003922
|
T060;T047
|
36,283,822
|
inflamm vascular diseas chronic venous diseas cardiovascular atherothrombot diseas high preval worldwid aetiopathogenesi vascular condit may share certain aetiopathogenet moment abnorm blood flow alter intravascular tension subsequ endotheli dysfunct may play import role anoth plausibl altern correl risk factor diseas particular obes metabol syndrom compon impact atherogenesi well chronic venous diseas relationship may even causal chronic vessel wall inflamm present advanc venous insuffici might acceler atherogenesi hand alter haemodynam right ventricular dysfunct subsequ elev venous pressur worsen induc venous insuffici andor undoubt caus symptom sign typic chronic venous diseas suggest find publish recent gutenberg health studi particular subanalysi regard relationship venous diseas cardiovascular diseas venous arteri bed affect common aetiopathogenet factor system interfer
|
D050197;D014689;D024821
|
T047;T046
|
36,283,821
|
take organ damag hypertens serious focus recent european guidelin earli initi antihypertens therapi risk group rapid achiev target blood pressur fix combin antihypertens drug best possibl manag individu cardiovascular risk earli intervent develop hypertens mediat organ damag hmod shown effect subsequ reduct risk cardiovascular event point hmod origin correl magnitud durat blood pressur elev clear defin boundari vascular damag begin develop reduct blood pressur pharmacotherapi demonstr decreas risk ischaem heart diseas stroke well mortal rate larg clinic trial consist shown signific reduct risk complic antihypertens medic across entir spectrum mild sever hypertens includ hypertens elder well isol systol hypertens base latest knowledg reduct blood pressur mere mm hg cardioprotect effect even normotens individu fundament chang view diagnosi definit hypertens diseas
|
D006973;D020521
|
T047
|
36,283,820
|
what new esc guidelin cardiovascular diseas prevent clinic practic esc guidelin cardiovascular diseas prevent clinic practic provid comprehens view prevent cardiolog present strategi reduc burden atherosclerot cardiovascular diseas cvd individu level popul level healthi lifestyl aggress control cardiovascular risk factor remain cornerston prevent classif individu risk group base clinic characterist follow stepwis treatment intensif novel recommend approach updat risk chart score score op intend estim year fatal non fatal cvd risk appar healthi individu target goal ldl cholesterol blood pressur glycaem control remain recommend recent esc guidelin
|
D002318;D002309;D050197;D019161
|
T121;T091;T109;T047;T046
|
36,283,819
|
diffus alveolar hemorrhag life threaten manifest newli diagnos granulomatosi polyangi follow covid infect case report case report patient newli diagnos granulomatosi polyangi gpa undergo covid coronavirus diseas discuss gpa one anca associ vascul character presenc autoantibodi cytoplasm enzym neutrophil anti neutrophil cytoplasmat antibodi vascul main affect small blood vessel lead damag kidney lung upper respiratori tract includ paranas sinus orbit diseas result acut life threaten condit complic includ diffus alveolar hemorrhag dah condit character blood leakag pulmonari vessel alveoli often lead acut vital sign even respiratori failur dah mani caus autoimmun diseas includ vasculitid well non immunolog caus earli adequ comprehens therapi includ immunosuppress treatment cyclophosphamiderituximab glucocorticoid life save
|
D014890;D000086382;D008171
|
T047;T067
|
36,283,818
|
earli diagnosi system scleroderma system scleroderma ssc system immun mediat connect tissu diseas character fibroproduct chang connect tissu microvascular disord diseas affect skin musculoskelet system intern organ diseas signific rate morbid mortal signific worsen qualiti life patient earli initi therapi necessari prevent diseas progress review articl discuss current possibl earli diagnosi system scleroderma
|
D003240;D012595
|
T047
|
36,283,817
|
news treatment axial spondyloarthr axial spondyloarthr rheumat diseas character inflamm bone format caus impair function spine affect joint basic research highlight key role dysregul tumor necrosi factor interleukin interleukin cytokin product etiolog axial spondyloarthr tumor necrosi factor interleukin inhibitor shown effect clinic trial current approv biolog diseas modifi drug diseas subgroup presum efficaci il blockad confirm two clinic trial anti il monoclon antibodi janus kinas inhibitor appear new treatment option
|
D025241;D000075242;D000089183;D001688
|
T121;T047;T123
|
36,283,816
|
new treatment system lupus erythematosus system lupus erythematosus treatment target achiev remiss low diseas activ protect diseas flare number immunosupres drug combin glucocorticoid use purpos increas possibl use biolog treatment especi belimumab calcineurin inhibitor voclosporin novelti lupus nephriti treatment anoth novelti anifrolumab biolog drug inhibit activ type interferon integr part care prevent late diseas complic especi cardiovascular risk manag
|
D008180;D007370;D001688
|
T129;T121;T123;T116;T047
|
36,283,815
|
treatment giant cell arter current approach new possibl giant cell arter gca autoimmun mediat system vascul affect larg arteri aorta branch highest incid system vasculitid manifest near exclus patient age older amongst non specif specif symptom headach mastic claudic sign rheumat polymyalgia relat common immedi treatment requir condit acut vision loss due optic ischemia gca diagnosi base clinic paraclin find imag techniqu includ petct import role still play histolog verif tempor arteri biopsi treatment base immunosuppress agent system glucocorticoid adjunct therapi option methotrex tocilizumab current also sever clinic trial examin efficaci modern biolog agent gca
|
D013700
|
T047
|
36,283,813
|
mid term success rate singl stage hybrid ablat persist long term persist atrial fibril singl stage thoracoscop radiofrequ ablat rfa treatment method persist long term persist atrial fibril af offer possibl patient otherwis inconsol convent cathet rfa present pilot group patient introduct new method clinic center patient group total patient age year underw singl stage hybrid ablat thoracoscop isol pulmonari vein box lesion follow cathet verif surgic procedur effectiv symptomat persist long term persist af signific dilat left atrium mm period septemb march
|
D001281;D017115;D011667
|
T061;T047;T046;T023
|
36,283,812
|
igg relat diseas clinic manifest differenti diagnosi recent intern diagnost criteria igg relat diseas immunoglobulin g relat diseas igg rd rare system fibro inflammatori disord autoimmun pancreat frequent manifest igg rd howev igg rd affect organ salivari gland orbit retroperitoneum prostat mani other recent research enabl clear clinic histopatholog descript igg rd four clinic phenotyp igg relat diseas describ diagnosi base morpholog examin typic find lymphoplasmocellular inflamm storiform fibrosi oblit phlebiti igg rd biopsi tissu invad plasma cell larg produc igg elev serum igg level found mani patient new diagnost criteria igg rd publish recent review summar current knowledg pathophysiolog clinic manifest diagnosi differenti diagnosi igg rd point view next articl bring overview igg rd therapi
|
D000077733;D001327
|
T047
|
36,283,796
|
implement evalu student scholarship program increas care initi rural pharmaci avail patient care servic rural area often lack reduc access care patient live area patient care within communiti pharmaci vital care access rural area expand pharmaci servic often challeng pharmaci student especi advanc pharmaci practic experi posit make impact site
|
D010594;D003157;D013339
|
T058;T097;T073;T093
|
36,283,795
|
counteract sedentari aspect academia incorpor physic activ educ process mani way tradit educ environ contribut sedentari lifestyl lead sever negat health outcom studi determin extent anti sedentari physic activ outcom result conduct pharmaci academia rotat topic discuss walk
|
D010604;D010593
|
T058;T170;T091;T057
|
36,283,794
|
novel pictogram improv pharmacist understand number need treat nnt number need treat nnt clinic use yardstick use gaug efficaci therapeut intervent object project develop pilot seri pictogram assess impact pharmacist understand nnt
|
D010595
|
T097
|
36,283,793
|
student pharmacist attitud percept knowledg regard opioid use misus overdos four year data american associ colleg pharmaci urg pharmaci faculti commit action reduc public health threat opioid use misus optim student pharmacist train necessit understand chang attitud percept time studi assess student attitud percept understand addict opioid use misus opioid overdos four sequenti year
|
D013339;D004512;D000083682;D062787;D009293
|
T065;T037;T097;T048
|
36,283,792
|
ultrahigh sensit select detect singl nucleotid polymorph use peptid nucleic acid ribonucleas h assembl dna amplif prada earli diagnosi monitor cancer best way increas surviv rate among patient cancer howev current cancer screen technolog expens time consum henc cancer screen remain challeng therefor develop relat inexpens high perform analyt method necessari especi mutat kras character singl nucleotid polymorph mutat therefor discrimin singl nucleotid polymorph essenti detect cancer mutat studi introduc method high sensit select real time pcr use peptid nucleic acid pna rnase h ii detect kras singl nucleotid polymorph method develop via fusion exist pna clamp pcr techniqu rnase h depend pcr techniqu synergist effect realiz mitig shortcom method method detect limit select studi demonstr complet valid test dna spike plasma sampl analysi cell cultur analysi blood sampl collect patient cancer furthermor demonstr applic method breath biopsi
|
D020135;D009369
|
T191;T114
|
36,283,791
|
dnazym regul crisprcasa base fluoresc biosensor sensit detect alkalin phosphatas activ inhibit alkalin phosphatas alp regard emerg biomark therapeut target various diseas herein develop dnazym regul crisprcasa cascad signal amplif strategi sensit select detect alp activ inhibit assay substrat strand cu specif dnazym design dna activ casa substrat strand would cleav two fragment alp catalyz hydrolysi reaction disabl complex cu pyrophosph ppi case cleav sequenc could bind casa crrna complex activ tran cleavag activ crisprcasa would hamper cleavag doubli label singl strand dna ssdna fluoresc report thus turn fluoresc signal cascad signal amplif strategi great improv detect sensit alp activ detect limit low ul moreov propos method success appli alp activ detect serum sampl alp inhibitori capabl evalu method overcom shortcom convent method show unsatisfactori sensit suscept interf substanc might hold great promis clinic diagnosi biomed research
|
D021881;D015374
|
T116;T075;T059;T126;T114
|
36,283,790
|
ultrasensit biosens platform fen activ detect base target induc primer extens trigger collater cleavag crisprcasa flap endonucleas fen structur select endonucleas essenti dna replic repair consid new promis marker earli cancer diagnosi howev reliabl sensit conveni biosensor fen detect still technic challeng herein fluorometr biosensor base target induc primer extens initi collater cleavag crisprcasa establish ultrasensit specif detect fen activ use branch dna probe fen activ cleav flap initi dna polymeras mediat primer extens produc plenti dna duplex contain protospac adjac motif pam act activ initi collater cleavag activ casa protein produc signific amplifi fluoresc respons ultrasensit determin fen activ develop biosens platform display excel analyt perform limit detect lod u l wide linear rang u l moreov propos strategi success use fen detect serum cell lysat suggest potenti clinic applic may provid reliabl approach fen allow effect diagnosi earli stage relat cancer
|
D045585;D015374
|
T059;T126;T116;T075
|
36,283,789
|
apam base sensit label free electrochem detect neutrophil gelatinas associ lipocalin via recycl amplif cascad sensit select detect neutrophil gelatinas associ lipocalin ngal critic predict earli diagnosi acut renal injuri work establish aptam base high sensit label free method detect ngal dilut human serum via metal ion depend dnazym exonucleas iii exo iii trigger recycl signal amplif cascad describ ngal bind aptam strand dnazymeaptam duplex result liber metal ion depend dnazym sequenc cleav hairpin signal probe electrod liber g quadruplex intermedi strand releas intermedi strand complement dnazymeaptam duplex form favor substrat exo iii digest duplex releas dnazym strand initi cascad recycl cycl yield plenti g quadruplex strand hemin associ g quadruplex strand produc mani g quadruplexhemin complex electrochem reduct hemin thus generat high amplifi current detect ngal detect limit ng ml biosensor also show high select util monitor ngal spike dilut serum indic extens potenti detect various protein biomark differ aptam diseas diagnosi
|
D021881;D054856;D015374;D052157
|
T116;T075;T059;T126;T114;T086
|
36,283,788
|
respons electrochem method estrogen effect toler cultur factor comparison mtt cell count method estrogen substanc environ increas dramat interfer normal hormon level human bodi lead disord endocrin system even cancer difficult screen larg number environment estrogen substanc exist estrogen effect detect method result often affect mani factor thus develop new method becom urgent task electrochem method promis reflect cell prolifer track intracellular purin base direct studi estrogen level mcf cell multiwal carbon nanotub modifi glassi carbon electrod mwcntsgce could track simpli conveni estrogen effect estradiol could reflect electrochemistri time dose depend manner electrochem method display best toler cultur factor differ cell densiti serum type cultur medium type serum estrogen free method respons estrogen effect higher mtt cell count method western blot analysi show estrogen effect estradiol promot purin catabol regul guanin deaminas gda adenin deaminas ada express key enzym purin catabol pathway dose depend manner regul gda ada led increas intracellular guanin xanthin enhanc electrochem signal deriv guanin xanthin
|
D037742;D006148
|
T104;T116;T126;T073
|
36,283,787
|
facil synthesi bioimxen heterostructur superior photoelectrochem sensor sensit detect glucos mxene base heterostructur bioiti c x synthes via simpl hydrotherm synthesi strategi bioiti c x exhibit distinct enhanc photoelectrochem pec activ excel durabl high select introduct ti c x could facilit separ photogener electron hole pair sinc redox process glucos result decreas photocurr bioiti c x bioiti c x base signal pec sens platform construct sensit determin glucos first time optim condit bioiti c x sensor display good linear rang limit detect sensor success appli glucos detect human urin satisfactori accuraci repeat confirm practic applic good servic moreov bioiti c x sensor also exhibit superb select stabil provid great potenti applic develop glucos sensor
|
D055664;D015374
|
T059;T075
|
36,283,786
|
autom centrifug less milk deprotein homogen liquid liquid extract sulfonamid onlin liquid chromatographi novel approach determin sulfonamid milk base lab syring techniqu present method involv autom salt liquid liquid extract analyt allow simultan sampl deprotein without requir centrifug manual sampl handl procedur paramet includ salt type solvent sampl ratio salt solut volum studi extract obtain dilut situ transfer onlin coupl liquid chromatographi analyt separ carri parallel subsequ extract way sampl throughput approxim h achiev detect limit rang g l use l milk sampl spectrophotometr detect applic develop method sampl analysi proven recoveri valu rang averag milk sampl differ fat content spike g ml level straightforward autom one labori prepar step food analysi ie deprotein demonstr
|
D008892;D013449
|
T168;T121;T109;T031
|
36,283,785
|
identifi robust reliabl volatil organ compound human sebum biomark discoveri sebum sebac gland rich sourc volatil organ compound voc readili sampl non invas surfac skin voc profil sebum use obtain inform regard differ medic condit includ diabet parkinson diseas howev effect sampl approach environment factor sebum voc profil establish confid attribut voc diseas state need free extran influenc sampl materi preparatori condit investig standardis skin swab sampl approach profil sebum voc healthi human subject use thermal desorpt gas chromatographi mass spectrometri td gc ms use standard gc ms method chemic analysi sebum swab surpris high number voc origin blank medic swab materi alon voc ambient environ voc base control experi found heat treatment medic swab prior gc ms reduc number voc detect blank swab improv reproduc voc profil howev signific voc absorpt still occur environment exposur ambient air voc identifi blank swab consist predomin hydrocarbon ester silicon base compound depend strong materi use cotton polyest rayon environment voc found absorb swab ambient air sampl includ butylheptyl benzen hexadecano acid methyl ester well exogen voc isopropyl palmit isopropyl myrist contrast sebum voc consist primarili ester alcohol keton aldehyd voc identifi sebum collect use polyest rayon cotton base medic swab respect voc common swab effect subject bath prior sebum sampl minim impact voc profil howev individu differ owe extern factor skin type diet exercis like influenc sebum product studi highlight import use rigor control sebum sampl recommend provid futur research involv sebum voc analysi exampl use sebum sampl replic across multipl day use control swab sampl collect requir confirm origin reliabl sebum voc anticip recommend conjunct librari well establish voc medic swab strengthen biomark identif result sebum voc analysi
|
D055549;D000393
|
T131;T109
|
36,283,784
|
ultrasensit evanesc wave optic fiber aptasensor onlin continu type specif detect sulfonamid environment water sensor capabl onlin continu monitor total sulfonamid environment water high desir due advers effect ecosystem unexpect concentr fluctuat divers present sensor capabl report studi evalu cross reactiv cr previous report sulfadimethoxin bind aptam use dnase assay found aptam type specif sulfonamid fabric first type specif sulfonamid sensor aptam immobil optic fiber evanesc wave sensor follow surfac coat tween competit bind sulfonamid cy label complementari dna enabl low femtomolar picomolar sensit detect total sulfonamid spike lake water sensor also exhibit high select regener capabl cycl stabil day short detect time min addit found crs great depend buffer composit perform parallel detect two buffer sensor detect sulfonamid divers coverag higher commerci elisa kit aptasensor fill technic gap continu monitor total sulfonamid environment water
|
D052157;D015374
|
T075;T059;T114
|
36,283,783
|
colorimetr supramolecular sensor array base charg transfer complex multiplex anilin phenol pollut detect order effect monitor toxic harm substanc sewag discharg rapid high sensit detect complex pollut similar structur becom urgent problem solv paper supramolecular colorimetr array sensor base charg transfer complex construct quick detect anilin phenol pollut p phenylenediamin phenylenediamin phenylenediamin aminophenol hydroquinon resorcinol similar structur six anilin phenol isom similar structur ad supramolecular colorimetr array sensor differ color chang produc natur light linear discrimin analysi lda show supramolecular colorimetr array sensor could recogn distinguish isom mixtur differ concentr ratio could well categor total euclidean distanc ted array pollut concentr good linear correl detect limit lod low mol l six anilin phenol isom real sampl identifi supramolecular colorimetr array sensor h nmr result show format charg transfer complex q caviti may caus color chang work provid fast conveni experiment basi monitor complex structur pollut sewag discharg
|
D003124;D004785
|
T131;T059
|
36,283,782
|
photoelectrochem sensor detect hg base situ generat mof like structur trace analysi mercuri ion hg great signific human health environment protect work novel photoelectrochem pec biosensor develop ultrasensit detect hg base mof like compositecd quantum dot qds photoact substrat materi mof like composit situ form hydrophob modifi algin hma europium ion eu offer friend platform bioconjug also result enhanc sensor photocurr respons furthermor immobil thymidin rich probe dna mof like composit surfac bent produc hg structur presenc hg result enlarg steric hindranc electrod surfac decreas propos biosensor pec respons propos photoelectrochem sens system display select detect hg linear rang pm detect limit pm util semiconductor quantum dot light harvest compon mof like composit sensit broaden possibl design idea photoelectrochem sens system
|
D019187;D045663;D015374;D008628
|
T073;T075;T131;T197;T196;T059
|
36,283,781
|
derivat sialyl glycopeptid plus base sialoglycopeptid enrich use cation exchang media glycosyl one import post translat modif howev character glycopeptid especi negat charg sialoglycopeptid associ various diseas remain challeng due co exist high abund peptid low ionize effici sialoglycopeptid result carboxyl group therefor essenti develop effici enrich method sialoglycopeptid present novel derivat base enrich method identifi linkag isom sialic acid generat mass differ ii unifi net charg peptid zero iii introduc posit charg sialoglycopeptid conjug quaternari ammonium sialic acid derivat term derivat sialyl glycopeptid plus dosg enabl effici enrich electrostat interact use weak cation exchang wcx media dosg base wcx enrich valid optim sampl deriv bovin fetuin peptid remov effici recoveri rate method employ human alpha acid glycoprotein agp recombin human erythropoietin epo demonstr applic dosg base wcx enrich complex n link link sialoglycopeptid method simpl effici target small scale sialoglycopeptid enrich
|
D004921;D064751
|
T121;T116;T104;T197;T125
|
36,283,780
|
mass spectrometri imag diclofenac metabolit tissu use nanospray desorpt electrospray ionize glucuronid common phase ii metabol process drug xenobiot increas solubl excret acyl glucuronid glucuronid carboxyl acid present concern implic gastrointestin toxic hepat failur despit substanti success bulk analysi speci previous attempt use tradit mass spectrometri imag msi techniqu complet partial fail therefor littl known local tissu herein use nanospray desorpt electrospray ionize mass spectrometri imag nano desi msi ambient liquid extract base ionize techniqu viabl altern msi techniqu examin local diclofenac wide use nonsteroid anti inflammatori drug metabolit mous kidney liver tissu msi data acquir broad mz rang show low signal drug metabolit result low ionize effici substanti signal suppress tissu signific improv signal nois obtain use select ion monitor sim mz window center around low abund ion interest use nano desi msi sim mode observ diclofenac acyl glucuronid hydroxydiclofenac local inner medulla cortex kidney respect consist previous report local enzym process diclofenac respect metabolit contrast uniform distribut diclofenac metabolit observ liver tissu concentr ratio diclofenac hydroxydiclofenac calcul nano desi msi data general agreement obtain use liquid chromatographi tandem mass spectrometri lc msms analysi collect result demonstr nano desi msi success use imag diclofenac primari metabolit deriv relat quantit data differ tissu region approach enabl better understand metabol process associ diclofenac drug difficult analyz use commerci avail msi platform
|
D021241;D004008
|
T121;T059;T109
|
36,283,779
|
simpl rapid electrochem monitor depolymer polyam acid excel thermal mechan properti aromat polyimid pis make attract materi various field pis perform use polyam acid paa precursor due limit solubl howev paa easili depolymer moistur heat degrad properti pis therefor qualiti control paa import task research industri applic propos simpl rapid novel method observ depolymer paa method base principl molecular weight polym decreas solut viscos decreas viscos solut easili rapid measur use electrochemistri acceler depolymer appli heat paa solut measur chang viscos solut cyclic voltammetri propos method also make possibl determin dynam viscos polym solut present model system observ state chang various polym
|
D011108;D001555
|
T104;T122;T109
|
36,283,778
|
cathod photoelectrochem sensor develop glutathion detect base carrier transport ti c x agi heterojunct recent cathod photoelectrochem pec sens emerg conveni effici method molecular detect analysi novel photoact materi urgent requir develop advanc cathod pec sensor studi origin photoact materi ti c x agi heterojunct materi hm synthes combin two dimension layer materi ti c x mxene p type semiconductor agi ti c x agi hm exhibit excel pec perform pec process ti c x agi hm light irradi explor demonstr use vienna abinitio simul packag vasp calcul ti c x agi hm exhibit enhanc electron hole separ charg transport owe good electron conduct ti c x improv interfaci electron transport ti c x agi therefor cathod pec sensor develop glutathion gsh detect gsh act reduct consum electron acceptor inhibit electron transfer result decreas photocurr signal linear gsh concentr linear rang wide detect limit nm pec sensor also display satisfactori select stabil thus find provid insight design construct pec sens platform without enzym
|
D019163;D015374
|
T130;T059;T075
|
36,283,777
|
magneticfluoresc dual modal later flow immunoassay base multifunct nanobead rapid accur sar cov nucleocapsid protein detect sar cov pandem pose huge challeng rapid accur diagnosi sar cov earli stage infect work develop novel magneticfluoresc dual modal later flow immunoassay lfia base multifunct nanobead rapid accur determin sar cov nucleocapsid protein np multifunct nanobead fabric use polyethyleneimin pei mediat shell combin superparamagnet fe core dual quantum dot shell magdqd core shell structur magdqd label high load densiti quantum dot qds superior magnet content realiz lfia dual quantit analysi modal assembl individu singl nanoparticl lfia integr advantag magnet signal fluoresc signal result excel accuraci quantit analysi high elast overal detect addit magnet signal fluoresc signal high sensit limit detect lod ng ml ng ml respect recoveri rate method simul saliva sampl magnet signal fluoresc signal result indic method consider potenti effect tool diagnos sar cov earli stage infect
|
D000086402;D000086382
|
T005;T067;T047
|
36,283,776
|
label free miniatur electrochem nanobiosensor triag platform swift identif bacteri type chronic wound rapid identif bacteri type critic immedi clinic assess novel cost effect label free electrochem nanobiosensor develop help indigen fabric carbon past work electrod rapid identifi bacteri type propos platform made use gold nanoparticl aunp boost electrochem activ strong affin boron acid moieti diol allow detect differenti gram gram bacteria platform scalabl robust miniatur electrochem cell e cell design develop electrod assist reduc sampl wast detect time limit detect lod within min propos nano biosens platform identifi escherichia coli e coli staphylococcus aureus aureus bacteria excel recoveri rate blind sampl size extra lipopolysaccharid lps layer contain diol bioelectrod demonstr superior respons e coli effect distinguish aureus furthermor propos biosens platform demonstr excel shelf life reproduc accept select exhibit excel specif toward bacteria make ideal candid rapid identif bacteri type
|
D015374;D053768
|
T059;T073;T075
|
36,283,775
|
applic electrokinet backflow enhanc pressur driven charg base separ sub micromet deep channel articl report signific improv resolv power pressur driven charg base separ perform sub micromet deep glass channel upon introduc electrokinet backflow system improv realiz axial electrophoresi aid pressur driven separ process negat charg glass conduit condit addit electroosmot backflow slow bulk transport background electrolyt subject sampl separ field prolong period yield higher fluid shear across channel depth assist separ process although increas shear also contribut addit hydrodynam dispers contribut usual small due fast diffus across flow streamlin sub micromet deep channel present work pressur driven flow generat chip fabric polyacrylamid base gel membran within chosen access hole upstream separ channel upon applic electr field across structur electroosmot flow generat open channel interfac membran partial block produc need pressur gradient optim electr voltag appli downstream end separ channel yield suitabl electrokinet backflow signific improv resolv power separ sampl compris three tamra se label amino acid note strategi improv separ resolut order magnitud compar case electrokinet backflow present band broaden separ also assess understand depend oper condit
|
D053841;D000596
|
T121;T123;T070;T116
|
36,283,774
|
graviti driven preprogram microfluid recircul system parallel biosens cell behavior fluid recircul import function organ chip microfluid applic systemat analysi simultan appli multi flow condit parallel channel essenti howev control parallel recircul flow without use dynam chip control drastic simplifi devic oper rare implement studi develop microfluid recircul system driven water head pressur pressur generat reservoir ml water volum drive system recircul l cell cultur media volum system realiz media recircul four parallel channel pulsatil constant flow preprogram manner system consist oscil cell cultur modul control flow rate shear stress wide rang l min dyn cm respect pulsatil flow puls period independ flow rate vari rang demonstr util devic systemat parallel analysi endotheli cell elong respons differ fluidic shear pattern perform addit cultur myoblast illustr myotub format success obtain day
|
D044085;D046210
|
T090;T059
|
36,283,773
|
activ constraint approach identifi essenti spectral inform noisi data multivari curv resolut mcr method aim extract pure compon profil mix spectral data appli high dimension data eg process spectroscopi hyperspectr imag techniqu one often observ part data name certain row column data matrix consid essenti mcr outcom part minor import method determin essenti data known differ disadvantag concern applic noisi data work present new approach detect essenti inform noisi experiment spectral data activ nonneg constraint combin dualiti argument key ingredi determin essenti spectra frequenc channel new approach conceptu simpl comput cheap stabl respect nois algorithm test noisi experiment raman uv vis ftir sec data
|
D000465
|
T170
|
36,283,772
|
trid lamp pump free microfluid chip duplex droplet digit loop mediat isotherm amplif analysi digit nucleic acid amplif techniqu power attract approach provid sensit absolut quantif biolog among digit loop mediat isotherm amplif dlamp show potenti field detect sinc robust independ thermal cycl key dlamp generat larg number individu droplet microwel howev auxiliari precis pump alway requir sampl digit addit current system droplet dlamp usual need transfer droplet digit amplif herein develop evalu pump free microfluid chip duplex droplet dlamp trid lamp detect chip design base step emulsif contain droplet generat zone droplet storag zone droplet form step due differ laplac pressur parallel nozzl could generat ten thousand uniform droplet manual variat storag zone droplet collect previous fill oil contain fluorosurfact keep droplet fuse evapor amplif therefor custom chip abl perform stage dlamp process without transfer droplet combin optim fluoresc probe method chip achiev accur quantif e coli dna copiesl proof concept simultan quantif two target success realiz custom chip conclus integr pump free trid lamp chip provid promis tool multipl target detect clinic diagnost point care applic
|
D044085;D046210
|
T090;T059
|
36,283,771
|
sens perform spinel ferrit mfe mg ni co mn cu zn base electrochem sensor review histori ferrit come mani centuri fundament mani field initi ferrit extract direct natur last centuri scientist learn produc ferrit differ properti gave origin mani advanc industri instrument applic recent design prepar ferrit nanometr size reveal remark characterist last year differ spinel ferrit use electroact layer build high perform modifi electrod review present critic overview util spinel ferrit general formula mfe mg ni co cu mn zn creat differenti voltammetr sensor associ materi graphen glassi carbon carbon nitrid ionic liquid nanoparticl nobl metal oxid transit metal materi produc notabl synerg respons toward electrochem activ sensor produc sensit signal ampl concentr rang compound hydrogen peroxid glucos bisphenol present potenti mani applic along review aspect discuss main result organ tabl use base metal associ ferrit
|
D006108;D052578
|
T120;T196;T103;T109
|
36,283,768
|
fast cancer yeast mammal fast fast mimick diet extend lifespan healthspan mous model decreas risk factor cancer age relat patholog human normal cell respond fast consequ decreas nutrient regul proto oncogen pathway enter stress resist mode protect differ cancer therapi contrast oncogen mutat constitut activ pathway includ ras akt pka allow cancer cell disobey fast depend anti growth signal import differ tumor type fast potenti toxic various therapi increas reactiv oxygen speci oxid stress ultim lead dna damag cell death effect limit chemotherapi sinc period fastingfmd cycl potenti effect tyrosin kinas inhibitor hormon therapi radiotherapi pharmacolog dose vitamin c addit anticanc effect fastingfmd also tumor independ involv immunotherapi like activ cell depend attack tumor cell support rang pre clinic studi clinic trial begin confirm safeti efficaci fastingfmd cycl improv potenti differ cancer therapi decreas side effect healthi cell tissu
|
D005215;D009369
|
T033;T055;T191
|
36,283,767
|
target amino acid metabol cancer metabol rewir characterist hallmark cancer cell phenomenon sustain uncontrol prolifer resist apoptosi increas nutrient energi suppli howev reprogram come togeth vulner use tumor appli target therapi last year genet background tumor identifi thorough new therapi target mutat test nevertheless propos target phenotyp cancer cell could anoth way treatment aim avoid drug resist non respons cancer patient amino acid metabol part alter process cancer cell amino acid build block also sensor signal pathway regul main biolog process comprehens review describ four amino acid asparagin arginin methionin cystein activ investig potenti target anti tumor therapi asparagin deplet success use decad treatment acut lymphoblast leukemia strong implic appli type tumor arginin auxotroph tumor great candid arginin starvat therapi higher requir essenti amino acid methionin cystein point promis target weak cancer cell
|
D001216;D009369
|
T123;T191;T116
|
36,283,765
|
autophagi induc nutrit intervent experiment clinic oncolog numer pro autophag dietari intervent investig potenti cancer prevent therapeut effect appli differ fast regimen methionin restrict ketogen diet addit supplement specif micronutri nicotinamid vitamin b spermidin induc autophagi human lean plant base diet may lead partial methionin restrict high dietari uptak spermidin associ low incid cancer moreov clinic trial demonstr capac nicotinamid prevent non melanoma skin carcinogenesi multipl intervent trial evalu capac autophagi induc regimen improv outcom chemotherapi immunotherapi discuss mechanist underpin autophagi induct nutrit intervent well mechan autophagi induct malign immun cell improv anticanc immunosurveil
|
D013095;D009369
|
T123;T191;T109
|
36,283,764
|
fast cancer respons therapi therapeut outcom multipl anticanc regimen reli upon fine balanc tumor intrins host relat factor context qualit chang dietari composit well alter total calori suppli influenc essenti aspect cancer biolog span tumor initi metastat spread one hand circumst nutrit imbal excess calori intak promot oncogenesi acceler tumor progress hamper efficaci anticanc treatment hand approach base bulk eg fast fast mimick diet select eg amino acid shortag nutrient current spotlight abil potenti effect anticanc drug chemosensit effect fast long attribut overdemand metabol requir neoplast cell recent find suggest calor restrict improv efficaci chemotherapi immunotherapi boost anticanc immunosurveil provid critic overview current preclin clinic studi address impact nutrit intervent respons cancer therapi lay particular emphasi fast relat intervent
|
D009369;D000970
|
T121;T191;T109
|
36,283,760
|
routin use patient report outcom measur hemodialysi care influenc patient clinician communic mix method studi patient report outcom measur invit patient self report aspect qualiti life report enhanc communic clinician aim examin routin use patient report outcom measur center hemodialysi unit influenc patient clinician communic
|
D011788;D000071066
|
T078;T170
|
36,283,759
|
toxic occup exposur membran nephropathi membran nephropathi rare autoimmun kidney diseas whose increas preval industri countri plead involv environment factor develop diseas addit predomin men membran nephropathi classic attribut biolog genet differ men women could also due differ occup exposur support hypothesi sought describ toxic occup exposur patient membran nephropathi
|
D015433;D001194;D016273
|
T131;T047;T037;T197
|
36,283,758
|
medic burden young adult juvenil idiopath arthriti data multicentr observ studi assess medic diseas burden young adult juvenil idiopath arthriti jia
|
D001171;D018501;D001688
|
T121;T047;T123
|
36,283,757
|
wors long term renal outcom lupus nephriti patient african descent live europ prognosi lupus nephriti ln among patient african descent live europ understudi
|
D008181;D051436
|
T047
|
36,283,756
|
canadian infant present brief resolv unexplain event brue valid clinic predict rule risk stratif protocol multicentr retrospect cohort studi brief resolv unexplain event brue common present among infant event benign self limit guidelin publish american academi pediatr inaccur identifi mani patient higher risk serious under aetiolog posit predict valu recent new clinic predict rule deriv accur stratifi patient data howev geograph limit usa larg studi date assess brue popul differ healthcar set studi aim describ clinic manag outcom infant present canadian hospit brue extern valid brue clinic predict rule identifi case
|
D000081415;D006760
|
T058;T170
|
36,283,755
|
cohort profil health trajectori immigr children cria prospect cohort studi metropolitan area lisbon portug cria health trajectori immigr children amadora cohort studi creat explor whether children expos migratori process experi differ health risk time includ physic health cognit socioemot behaviour challeng differ healthcar utilis pattern
|
D002161;D000086382;D054242
|
T098;T047;T015;T067
|
36,283,754
|
pathway neighbourhood factor stress glycaem control individu type diabet southeastern unit state cross section pathway analysi understand pathway neighbourhood factor influenc glycaem control may crucial address health dispar diabet studi aim examin pathway neighbourhood factor glycaem control mediat stress
|
D003924
|
T047
|
36,283,753
|
occup health hazard among healthcar provid ancillari staff ghana scope review strict implement occup health safeti polici curb exposur occup hazard howev empir evid lack ghanaian context review primarili aim explor exposur occup hazard among healthcar provid ancillari staff ghana
|
D016272;D016273
|
T078;T091;T037
|
36,283,752
|
challeng way cope parturi women chronic hepat b ghana covid pandem qualit inquiri explor psychosoci concern way cope pregnant women chronic hepat b infect ghana
|
D019694;D000086382;D006509
|
T047;T067
|
36,283,751
|
protocol systemat review meta analysi minim import differ generic multiattribut util instrument generic multiattribut util instrument maui effici tool determin enumer health relat qualiti life maui accomplish generat health state util hsus via algorithm minim import differ mid assist interpret hsus estim minimum chang clinic signific overal goal propos systemat review meta analysi develop comprehens guidelin mid estim
|
D011788;D012107
|
T078;T062;T096;T170;T081;T169
|
36,283,750
|
autolog cultur adipos deriv mesenchym stem cell combin hyaluron acid hydrogel treatment discogen low back pain studi protocol phase ii randomis control trial discogen low back pain dlbp common diseas occurr close relat intervertebr disc ivd degener present none tradit treatment method repair degener ivd emerg stem cell therapi make possibl repair regener ivd tissu among adipos deriv mesenchym stem cell admsc transplant therapi becom hot spot current research therefor trial aim investig safeti efficaci use autolog cultur admsc combin hyaluron acid ha hydrogel treatment dlbp
|
D017116;D059630
|
T184;T047;T025
|
36,283,749
|
built environ child health wale australia beach studi protocol childhood obes physic inact two signific modifi risk factor prevent non communic diseas ncds yet third children wale australia overweight obes uk australian children suffici activ purpos built environ child health wale australia beach studi identifi understand complex interact factor built environ influenc modifi risk factor ncds across childhood
|
D000067576;D063766
|
T078;T058;T033;T047
|
36,283,748
|
seri virtual light therapi intervent fatigu feasibl pilot studi protocol seri personalis n trial fatigu one common record patient symptom result deficit aspect psychomotor function cognit work perform mood research show bright light dim light therapi may efficaci way reduc symptom fatigu still feasibl scalabl individu treatment effect advers event heterogen treatment unknown
|
D005221;D010789
|
T061;T184
|
36,283,747
|
incid outcom acut mesenter ischaemia systemat review meta analysi estim incid acut mesenter ischaemia ami proport differ form short term long term mortal
|
D065666;D013927
|
T047;T046
|
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