PMID
int64 35.7M
36.4M
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36,278,527
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resum swallow oral feed tracheostom covid patient experi swiss covid center narrat literatur review covid pandem percutan tracheostomi prove effect option manag patient prolong period intub fact among thing allow earli discharg icus contribut reduc overcrowd intens care set central critic point covid pandem direct consequ manag wean frail tracheostom ventil patient divert sub intens normal hospit ward one central challeng set resumpt swallow oral feed requir interdisciplinari manag involv phoniatrician ent pneumologist speech therapist articl aim share experi swiss covid center draw narrat review issu concern manag tracheostomi cannula swallow resumpt integr recent evid literatur clinic experi profession direct involv manag tracheostom covid patient view heterogen covid patient believ procedur describ articl applic larger popul patient undergo tracheostomi wean
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D003679;D000086382
|
T047;T040;T067
|
36,278,526
|
pilot studi electrocardiograph featur patient obes tertiari care centr southern india electron background obes associ increas caus mortal cardiovascular diseas cvd electrocardiogram ecg may use screen subtl sign cvd alter cardiac morpholog obes methodolog observ cross section analys ecg chang patient obes tertiari care centr southern india result one hundr fifti adult patient mean sd bmi kgm recruit studi exclud comorbid diabet mellitus system hypertens chronic medic ace inhibitor cohort show femal predomin mean sd age year patient exhibit sinus rhythm one patient show featur first degre conduct block sinus tachycardia seen patient observ left right ventricular hypertrophi five three patient respect observ ecg pattern includ prolong qtc patient invert wave most inferior lead patient st segment depress predomin later lead patient greater preval note morbid obes death report cohort conclus predomin ecg variat cohort includ tachycardia atrial enlarg ventricular hypertrophi conduct defect lad featur ischemia old infarct repolar abnorm greater preval morbid obes studi need assess impact weight reduc measur revers chang determin associ outcom obes patient
|
D009767;D002318
|
T047
|
36,278,525
|
train induc muscl fatigu power lower limb exoskeleton preliminari studi healthi subject power lower limb exoskeleton repres promis technolog help upright stanc gait peopl lower bodi paralysi sever paresi spinal cord injuri power lower limb exoskeleton assist reduc develop lower limb muscular fatigu risk factor spastic therefor measur power lower limb exoskeleton train induc fatigu relev guid improv technolog develop preliminari studi thirti healthi subject age year perform three motor task walk overground wo ii treadmil walk wt iii stand sit sts three separ exoskeleton base train session min chang product lower limb maxim voluntari isometr contract mvic assess knee ankl dorsiflexion extens three exoskeleton base train motor task mvic forc decreas signific three train motor task except ankl dorsiflexion howev signific interact found time train train session except knee flexion signific fatigu induc wo wt train motor task result studi pose basi generat data use better approach exoskeleton base train sts task lead lower level muscular fatigu especi knee flexor muscl
|
D000067190
|
T074
|
36,278,524
|
easi intra oper local pulmonari nodul uniport video assist thoracoscopi experi hydrogel plug institut diffus lung cancer screen program increas detect solid ground glass opac ggo sub centimetr lesion lead necess histolog diagnos percutan ct guid biopsi may challeng thus make surgic excis valid diagnost altern ct guid hydrogel plug deploy biosentri recent propos simplifi intraop nodul local report initi experi
|
D003074;D008175;D055613
|
T033;T047;T191
|
36,278,523
|
time load resist train improv health women polycyst ovari syndrom pcos scope review guidelin manag polycyst ovari syndrom pcos focus lifestyl chang incorpor exercis whilst evid suggest aerob exercis may benefici less known effect resist train rt may feasibl low fit level andor unabl tolerateparticip aerob exercis
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D011085;D055070
|
T061;T047
|
36,278,514
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non invas posit pressur ventil central sleep apnoea adult central sleep apnoea csa characteris abnorm pattern ventil sleep due dysfunct drive breath consequ peopl csa may present poor sleep qualiti sleep fragment inattent fatigu daytim sleepi reduc qualiti life
|
D020182;D020181;D006970;D006333
|
T184;T033;T047;T046;T048
|
36,278,506
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phenol releas pnipam hydrogel scale molecular dynam simul dynam densiti function theori employ molecular dynam simul md bennett accept ratio method comput free energi transfer g tran phenol methan fluorouracil fu bulk water water pnipam mixtur differ polym volum fraction p purpos first calcul solvat free energi media obtain g tran phenol fu medic use treat cancer attach pnipam surfac show negat valu g tran irrespect temperatur lower critic solut temperatur pnipam c convers methan switch g tran sign consid temperatur posit negat c case contrast theoret predict g tran maintain linear behavior pnipam concentr larg polym densiti also employ md comput diffus coeffici phenol water pnipam mixtur function p dilut limit g tran function p requir input obtain releas halftim hollow pnipam microgel dynam densiti function theori ddft scale strategi captur experiment valu radius microgel caviti p k
|
D056004;D000080386
|
T066;T122;T044
|
36,278,498
|
iodin promot cyclize n n diphenylthiocarbamid enaminon protocol synthesi poli substitut iminothiazolin iodin promot cyclize reaction n n diphenylthiocarbamid enaminon achiev provid seri poli substitut iminothiazolin protocol transit metal free simpl perform broad function group toler good excel yield mild reaction condit show potenti synthet valu prepar divers biolog pharmaceut activ compound
|
D007455
|
T123;T196;T121
|
36,278,495
|
pheharmin b two pair racem alkaloid morpholino hi carbolin core root peganum harmala two pair unpreced carbolin phenylpropanoid heterogen alkaloid pheharmin b character morpholino hi carbolin core two chiral center isol root peganum harmala structur includ absolut configur identifi use spectroscop analys electron circular dichroism ecd calcul biosynthet hypothesi format pheharmin b propos compound exhibit moder cytotox activ hl cell line
|
D032443;D000470
|
T123;T121;T109;T131;T002
|
36,278,490
|
benefit global mutant huntingtin lower diminish time huntington diseas mous model develop induc huntington diseas hd mous model allow tempor control whole bodi allel specif mutant huntingtin mhtt express ask whether moder global lower mhtt suffici long term amelior hd relat deficit whether earli mhtt lower measur deficit requir earli late mhtt lower delay behavior dysfunct mhtt protein aggreg measur biochem howev long term follow reveal benefit mhtt lower group attenu month age earli mhtt lower attenu cortic striatal transcript dysregul evalu month age benefit diminish month age late mhtt lower amelior striatal transcript dysregul month age earli mhtt lower delay elev cerebrospin fluid neurofila light chain observ model start month age small molecul htt lower therapeut progress clinic find suggest moder mhtt lower allow diseas progress continu albeit slower rate could relev degre mhtt lower requir sustain long term benefit human
|
D006816
|
T047
|
36,278,489
|
gene therapi synthet adeno associ viral vector improv audiovestibular phenotyp pjvk mutant mice recess pjvk mutat caus defici pejvakin protein express sensori hair cell first order neuron inner ear import caus hereditari hear impair patient pjvk mutat garner limit benefit cochlear implant thus altern biolog therapi may requir address clinic difficulti synthet adeno associ viral vector ancl wide tropism high transduct effici various inner ear cell may provid solut deliv pjvk transgen inner ear pjvk mutant mice use synthet ancl vector observ robust exogen pejvakin express hair cell neuron cochlea vestibular organ subsequ morpholog audiolog studi demonstr signific restor spiral ganglion neuron densiti hair cell cochlea along partial recoveri sensorineur hear impair addit observ recoveri vestibular ganglion neuron balanc function wt level studi demonstr util ancl mediat gene deliveri pjvk mutant mice provid insight potenti gene therapi pjvk relat inner ear deficit
|
D015316;D006319
|
T061;T047
|
36,278,488
|
spatial metabolom reveal upregul sever pyrophosph produc pathway cortic bone hyp mice patient renal phosphat wast diseas x link hypophosphatemia xlh hyp mice murin homolog xlh character loss function mutat phosphat regul endopeptidas homolog x link phex lead excess secret bone deriv phosphotrop hormon fgf miner defect patient xlh hyp mice caus combin hypophosphatemia local accumul miner inhibit molecul bone howev mechan phex defici regul bone cell metabol remain elus use spatial metabolom employ matrix assist laser desorptionion maldi fourier transform ion cyclotron reson mass spectrometri imag msi undecalcifi bone cryosect character situ metabol chang bone hyp mice holist unbias manner found complex chang hyp bone metabol includ perturb pentos phosphat purin pyrimidin phospholipid metabol import studi identifi upregul sever biochem pathway involv intra extracellular product miner inhibitor pyrophosph bone matrix hyp mice data emphas util msi base spatial metabolom bone research provid holist situ insight phex defici induc chang biochem pathway bone cell link impair bone miner
|
D053098
|
T047
|
36,278,487
|
dichloroacet thiamin improv surviv mitochondri stress c elegan model dihydrolipoamid dehydrogenas defici dihydrolipoamid dehydrogenas dld defici recess mitochondri disord caus deplet dld ketoacid dehydrogenas complex caenorhabd elegan anim model dld defici generat grade feed dld rnai reveal full partial reduct dld express recapitul increas pyruv level typic pyruv dehydrogenas complex defici signific alter anim surviv health reduct brood size adult length neuromuscular function dld defici dramat increas mitochondri unfold protein stress respons induct adapt mitochondri prolifer atp level reduc respiratori chain enzym activ vivo mitochondri membran potenti signific alter dld deplet direct correl induct mitochondri stress impair worm growth neuromuscular function safeti efficaci dichloroacet thiamin riboflavin aminoimidazol carboxamid ribofuranosid aicar l carnitin lipoic acid supplement therapi empir use human dld diseas object evalu life span mitochondri stress respons studi dichloroacet thiamin show individu synergist therapeut benefit collect c elegan dld rnai anim model studi demonstr translat relev preclin model diseas mechan therapeut candid result suggest clinic trial warrant evalu safeti efficaci dichloroacet thiamin human dld diseas
|
D013831;D008063
|
T121;T127;T109
|
36,278,486
|
distinct pattern respons endotheli cell smooth muscl cell follow vascular injuri vascular smooth muscl cell smcs heterogen differenti respons vascular injuri well understood address question perform singl cell analysi vascular cell ligat injuri mous carotid arteri day endotheli cell homogen activ mesenchym gene less smcs respond injuri generat distinct cluster ie proinflammatori smcs stress respons smcs proinflammatori smcs enrich high level inflammatori marker vascular cell adhes molecul stress respons smcs overexpress heat shock protein trajectori analysi suggest proinflammatori smcs potenti deriv specif subpopul smcs ligand receptor pair analysi show interact macrophag proinflammatori smcs major cell cell communic among cell type injur arteri vitro cocultur demonstr vcam smcs stronger chemotact effect macrophag recruit vcam smcs consist number vcam smcs signific increas injur arteri atherosclerot lesion apo mice human arteri find provid insight singl cell level distinct pattern endotheli cell smc respons vascular injuri
|
D042783;D057772
|
T025;T037
|
36,278,485
|
subtyp c hiv reservoir throughout bodi art suppress individu subtyp b hiv reservoir intens investig reservoir subtyp respond antiretrovir therapi art substanti less establish character subtyp c hiv reservoir implement postmortem frozen well formalin fix paraffin embed ffpe tissu sampl central nervous system cns peripher tissu hiv ltr gag envelop env dna rna quantifi use genom dna rna extract frozen tissu rnascop use local subtyp c hiv dna rna ffpe tissu despit uniform viral load suppress cohort pcr result show subtyp c hiv provir copi vari magnitud tissu distribut detect primarili secondari lymphoid tissu interest appendix harbor provirus subject unlik subtyp b subtyp c provirus rare detect cns detect hiv rna hiv rna detect peripher lymphoid tissu art suppress case addit activ hiv express lymphoid tissu rnascop reveal hiv rna detect cd express cell appendix suggest tissu previous unreport potenti treatment resist reservoir subtyp c hiv
|
D015497;D015658
|
T005;T047
|
36,278,484
|
intraperiton inject class tlr agonist enhanc anti pd immunotherapi colorect periton metastas periton metastas associ low respons rate immun checkpoint blockad icb therapi number periton resid macrophag prms revers correl respons rate icb therapi previous shown tlr fibroblast reticular cell frcs play critic role regul periton immun cell recruit howev role tlr frcs regul prms unclear demonstr class tlr agonist odn mark enhanc efficaci anti pd therapi mous model colorect periton metastas odn inject ip reduc number tim prms enhanc cd cell antitumor immun mechanist treatment odn suppress express gene requir retinoid metabol frcs associ reduc express prm lineag defin transcript factor gata select delet tlr frcs diminish benefit odn anti pd therapi reduc periton metastas crosstalk prms frcs may util develop new strategi improv efficaci icb therapi periton metastas
|
D010534;D015179
|
T191
|
36,278,483
|
random phase trial antigen specif toler immunotherapi peptidecalcitriol liposom acpa rheumatoid arthriti backgroundantigen specif regul autoimmun diseas major goal seroposit rheumatoid arthriti ra cell help autoreact b cell matur citrullin cit antigen specif immun respons generat ra specif v domain glycosyl anti cit protein antibodi acpa vdg arthriti onset low escal antigen administr sub immunogen condit favor toler explor safeti pharmacokinet immunolog clinic effect sc den compris liposom encapsul self peptid collagen ii cii nf b inhibitor dihydroxycholecalciferolmethodsa doubl blind placebo control exploratori singl ascend dose phase trial assess impact low medium high den dose peripher blood cii specif bystand citvimentin specif cit vim specif autoreact cell respons cytokin acpa hla drb acpa ra patient methotrexateresultsden well toler relat placebo normal baselin valu cit vim specif cell decreas patient administ medium high dose den relat placebo percentag cii specif program cell death cell increas within day den exploratori analysi den treat patient suggest improv ra diseas activ associ expans cii specif cit vim specif cell reduct acpa vdg memori b cell inflammatori myeloid popul enrich ccr naiv cell singl cell sequenc identifi cell transcript associ tolerogen tcr signal exhaust low medium dose den conclusionth safeti immunomodulatori activ lowmedium den dose provid rational assess antigen specif immunomodulatori therapi acpa ratrial registrationanzctrorgau identifi actrn updat septemb fundinginnov medicin initi joint undertak grant agreement support european union horizon research innov programm european feder pharmaceut industri associ arthriti queensland nation health medic research council nhmrc senior research fellowship nhmrc grant
|
D002117;D001172
|
T121;T127;T109;T125;T047
|
36,278,482
|
longitudin associ insulin resist chang bone miner densiti midlif women backgroundth effect insulin resist bone miner densiti bmd unclearmethodsin studi women health across nation swan particip use multivari regress test averag insulin resist homeostat model assess insulin resist homa ir rate chang insulin resist predictor rate chang lumbar spine ls femor neck fn bmd stage premenopaus n menopaus transit mt n postmenopaus n model control age averag bw chang bw cigarett use race ethnic studi siteresultsth relat homa ir bmd declin biphas averag loghoma ir less greater homa ir associ slower bmd declin ie doubl averag homa ir premenopaus associ p ls p fn gcm per year slower bmd loss greater equal averag loghoma ir associ bmd chang women homa ir decreas premenopaus associ homa ir chang rate bmd chang rate posit ie slower homa ir declin associ slower bmd loss women insulin resist increas premenopaus associ negat ie faster homa ir rise associ faster bmd declin associ averag homa ir homa ir chang rate bmd chang rate similar postmenopaus weaker mtconclusionwhen decreas insulin resist associ bmd preserv increas insulin resist associ bmd lossfundingth swan grant support nih depart health human servic dhhs nih nation institut age nia nation institut nurs research ninr offic research women health orwh grant unr uag uag uag uag uag uag uag uag uag
|
D015519;D007333
|
T201;T081;T046
|
36,278,481
|
nox inhibit promot remodel dystroph muscl muscular dystrophi mds genet muscl diseas result progress muscl degener follow fibrot replac affect muscl regen process fail therapeut specif address fibrosi fail regener associ mds repres major unmet clinic need md patient particular advanc stage diseas progress current studi investig target nad p h oxidas nox potenti strategi reduc fibrosi promot regener diseas burden muscl model duchenn muscular dystrophi dmd nox elev muscl dystroph mice dmd patient local primarili interstiti cell locat muscl fiber genet pharmacolog target nox signific reduc fibrosi dystroph respiratori limb muscl mechanist nox target decreas number fibrosi deposit cell myofibroblast restor number muscl specif stem cell satellit cell local physiolog nich therebi rejuven muscl regener furthermor acut inhibit nox suffici induc apoptot clear myofibroblast within dystroph muscl data indic target nox effect strategi promot benefici remodel diseas burden muscl repres dmd potenti mds muscl patholog
|
D012038;D020388
|
T047;T042
|
36,278,473
|
total synthes wentilacton b relat norditerpen dilacton wentilacton b two repres tetranorditerpenoid dilacton promis antitumor activ synthes first time synthesi employ hydroxydilacton common precursor deriv wieland miescher keton lead easili deriv various modif ring cj asperolid b unnam natur congen
|
D004224
|
T109
|
36,278,428
|
platelet rich plasma enhanc effect meniscus repair meta analysi random control trial platelet rich plasma meniscus repair studi shown platelet rich plasma prp enhanc effect meniscus repair studi suggest differ view role prp
|
D053657;D019645;D000072600;D020370
|
T061;T047;T023;T031
|
36,278,418
|
investig acyl transfer auxiliari assist glycoconjug glycoprotein semi synthesi homogen glycoprotein synthes becom possibl last decad due advanc chemic ligat strategi particular nativ chemic ligat ncl nativ glycoprotein still requir labori technic challeng synthes glycopeptid compon combin multi segment ligat reaction explor new reaction sugar link acyl transfer auxiliari peptid thioester show nativ glycoprotein difficult produc use approach various relat analogu access result show site specif neoglycoconjug viabl rout simpli glycosyl protein may extend use well document enzymat process
|
D006020;D010455
|
T121;T116
|
36,278,416
|
tempor relationship arteri stiff systol blood pressur intens standard control post hoc analysi step trial whether tempor relationship arteri stiff systol blood pressur sbp affect strict sbp control intens mm hg standard mm hg unclear
|
D059289;D006973
|
T047;T046
|
36,278,415
|
simultan quantif nicotin salt e liquid lc msms gc ms nicotin salt form nicotin organ acid common ad electron cigarett liquid abil provid desir sensori effect analyt strategi develop detect type organ acid nicotin level method direct measur nicotin salt still desir herein novel approach present simultan quantif non volatil volatil nicotin salt via liquid chromatographytandem mass spectroscopi lc msms gas chromatographymass spectroscopi gc ms approach valid recoveri experi yield recoveri valu method first techniqu quantifi multipl nicotin salt could present commerci e liquid without use derivat step differ nicotin salt could detect rapid conveni new method demonstr e cigarett liquid sampl provid satisfactori outcom could use studi organ acid proton nicotin e liquid releas behaviour nicotin salt electron cigarett
|
D009538;D066300
|
T121;T073;T131;T109
|
36,278,405
|
right ventricular maladapt pressur overload fischer rat associ profound defici adenyl kinas impair ventricular energet explor mechan maladapt right ventricular rv remodel fischer compar spragu dawley sd rat expos pressur overload
|
D006352;D006333
|
T023;T046;T047
|
36,278,397
|
effect univers adhes long term bond strength zirconia evalu effect univers adhes long term bond strength yttria stabil tetragon zirconia polycryst tzp
|
D001840
|
T061
|
36,278,320
|
advanc applic piezoelectron electron cell regul tissu regener bioelectr play signific role major biolog process electr stimul effect non invas way promot cellular growth differenti tissu regener tissu engin piezoelectr materi act modul regul behavior function cell tissu also use scaffold regul guid cell growth matrix synthesi thus promot format new tissu piezoelectron electron produc piezoelectr materi upon mechan stimuli similar effect cell extern electr field devic base piezoelectron wide appli bioelectron biomed field review effect piezoelectron electron cell possibl mechan briefli introduc overview applic piezoelectron electron cell regul tissu regener accord type cell tissu final futur perspect challeng also provid
|
D054457;D004583
|
T081;T122;T196
|
36,278,317
|
predict configur energi dna nucleosom coars grain model nucleosom bind propens dna crucial understand gene express regul therefor import understand specif dna sequenc self organis optimis process wrap nucleosom end develop procedur predict configur need nucleosom form start examin set chosen experiment structur nucleosom find regular classif allow us defin structur constraint dna wound around histon use cgdna model coars grain model dna base phosphat comput free energi given dna configur given sequenc minimis free energi subject aforement structur constraint result prefer configur given dna sequenc nucleosom energet cost form nucleosom particular dna sequenc comput use framework compar energet cost persist length dna sequenc verifi whether less rigid lower persist length sequenc requir less energi wrap nucleosom
|
D009707;D004247
|
T123;T116;T114
|
36,278,316
|
robert warington heinrich friendship co oper chemistri nineteenth centuri britain germani paper discuss fourteen letter heinrich justus liebig successor univers giessen sent robert warington chemic oper apothecari hall london correspond illumin rang topic relat develop british chemic communiti mid victorian britain organis network commerci opportun well offer insight import famili friendship collegi sustain scientif career studi exchang materi textual knowledg help understand scienc organis idea dissemin key period institut develop chemistri
|
D033062
|
T098;T054
|
36,278,313
|
ag induc regioselect huisgen cycloaddit synthesi fulli substitut pyrazol potenti anticanc agent effici regioselect synthesi novel fulli substitut pyrazol achiev huisgen cycloaddit reaction acetoxi alleno hydrazonoyl chlorid addit ag present approach offer advantag simpl high effici mild condit wide substrat scope good excel regioselect strategi could perform larg scale pattern allow access structur versatil pyrazol key intermedi lonazolac nonsteroid anti inflammatori drug could synthes effici moreov sever pyrazol show obvious growth inhibitori activ huh cell expect potenti anticanc agent
|
D011720;D000970
|
T121;T109
|
36,278,312
|
click chemistri fluoresc imag via combin bodipi base turn probe norbornen glucosamin present studi synthes novel near infrar turn bodipi probe new norbornen modifi glucosamin deriv probe exhibit signific nir fluoresc emiss turn respons perform tumour specif imag tumour bear mice non natur glucosamin provid metabol glycoengin label express cell chemic tag react fluoresc dye cell label combin two deriv enabl quick sensit cell imag vitro vivo use iedda reaction
|
D057930;D009369
|
T062;T070;T191
|
36,278,310
|
studi catalyt degrad acid orang potenti mechan ferrous percarbon factor affect degrad acid orang ao evalu optim ferrous use catalyz percarbon present studi optim condit includ initi ph valu rang ao solut initi level ao sodium percarbon spc fe ion natur organ materi common exist natur water also test evalu potenti impact degrad ao degrad effici ao optim test condit ferrouspercarbonateao molar ratio mmoll ao aqueous solut presenc cl na mg affect remov ao addit hco signific inhibit remov even concentr hco low mmoll slight inhibit effect observ ad concentr humic acid rang mgl wherea residu ao signific enhanc level humic acid continu increas mgl hydroxyl radic oh main reactiv intermedi control oxid ao present fe spc system produc intermedi degrad ao identifi includ coumaranon naphthol phthalic acid phthalimid n methylnaphthylamin methylphenol propos degrad pathway consist radic format identifi intermedi practition point ferrouspercarbon system remov ao optim condit ao remov inhibit ad hco humic acid affect cl na mg hydroxyl ring open miner driven generat hydroxyl radic deriv major process degrad ao
|
D006812;D014874
|
T123;T131;T109
|
36,278,302
|
new insight ruthenium ii metallodendrim anticanc drug nanocarri synthesi preclin behaviour dendrim studi promis materi deliveri anticanc drug work low generat nitril poli alkylidenamin base dendrim explor nanocarri organometal complex ru c h pph rucp investig anticanc action involv mechan evalu vitro vivo observ biolog behaviour generat depend highest generat metallodendrim gru overal effect metallodendrim gru activ set six cancer cell line reveal import select cell ic valu fold lower non cancer cell import vivo studi gru mcf xenograft mous model show exhibit low system toxic low accumul main organ mice preferenti accumul tumour remark capac limit tumour growth vitro vivo studi reveal gru caus high level cell necrosi apoptosi vitro cell death mechan studi show capac gru induc mitochondri depolar ros product altogeth pre clinic result indic gru promis anticanc drug potenti low generat poli alkylidenamin base dendrim drug nanocarri
|
D012428;D050091;D000970
|
T121;T109;T104;T196;T122
|
36,278,295
|
endolumin larynx anatomi model toward facilit deep learn defin standard medic imag evalu artifici intellig algorithm pioneer natur work cover answer two question date anatom model larynx need modern endoscop diagnost digit segment model util deep learn purpos idea present articl never propos breakthrough numer approach aerodigest videoendoscopi imag approach describ articl assum defin process data acquisit integr segment label need new branch knowledg digit medicin digit diagnosi support expert system first crucial step process creat digit model larynx valid util multipl clinic well technic metric model form basi artifici intellig ai requir may also contribut develop translat medicin
|
D000077321;D007830
|
T023;T066;T030
|
36,278,292
|
physician health well physician health well complex topic relev pediatrician survey studi establish pediatrician experi burnout compar rate colleagu across medic specialti preval burnout increas pediatr disciplin time general pediatrician experienc increas burnout pediatr medic subspecialist pediatr surgic specialist experienc slight higher baselin rate burnout similar increas women current constitut major pediatrician survey report higher preval burnout women physician compar male counterpart purpos report updat reader explor approach pediatrician well reduct occup burnout risk throughout stage train practic topic cover includ burnout preval diagnosi overview nation progress physician well updat physician well initi american academi pediatr updat pediatr specif burnout well recogn driver burnout organiz individu review intersect race ethnic gender burnout protect factor compon well organiz individu develop clinic report inevit shape social cultur public health econom factor current affect communiti coronavirus diseas covid pandem layer new signific stressor onto medic practic physic mental logist challeng effect ignor
|
D000086382;D010820;D002055;D008511
|
T091;T067;T097;T047;T048
|
36,278,285
|
imag practic implic young infant urinari tract infect manag infant age day urinari tract infect uti challeng examin renal imag infant age day uti tertiari care children hospit identifi impact standard renal ultrasound rus interpret
|
D014718;D014552
|
T047
|
36,278,279
|
understand patient assess treatment deep vein thrombosi deep vein thrombosi dvt common develop deep vein leg potenti form part bodi sever risk factor associ dvt includ prolong immobl malign recent surgeri famili histori one main risk dvt thrombus form vein may travel bodi becom lodg pulmonari system caus pulmonari embol life threaten uk specialist servic diagnost pathway develop speed diagnosi treatment dvt mani nurs led articl use case studi outlin assess patient suspect dvt treatment patient confirm diagnosi dvt
|
D020246;D011655
|
T047;T046
|
36,278,276
|
checklist report research advanc clinic experiment medicin choos proper one manuscript various guidelin author research paper checklist often accompani statement play import role creation care written scientif paper author serv tool ensur correct structur content manuscript increas chanc paper publish journal high reject rate aim editori provid concis outlin checklist frequent use guid structur paper publish advanc clinic experiment medicin support current prospect author journal choos checklist manuscriptth equat websit present use tool choos checklist https wwwequat networkorg checklist popular among author publish work advanc clinic experiment medicin outlin strobe observ studi arriv area bioscienc research use laboratori anim casp qualit studi consort parallel group random trial prisma review meta analys squir studi qualiti improv healthcar stard diagnost accuraci studi remark tumor marker prognost studi present checklist discuss follow order name checklist explain type articl intend point structur checklist explain extens present checklist specif subtyp paper list import literatur present checklist provideda take home messag basic tip choos checklist formul final exampl paper adher discuss checklist provid
|
D057189;D035843
|
T062;T170
|
36,278,275
|
assess frailti syndrom cardiac surgeri frailti syndrom fs one import variabl proven impact increas risk morbid mortal cardiac surgeri howev fs assess routin incorpor daili clinic practic includ common use risk assess model inclus fs periop risk predict model cardiac surgeri would allow accur assess could also assist select appropri treatment strategi favor appropri use clinic resourc identif fs qualif process must seen absolut contraind cardiac surgeri opportun adequ prepar patient procedur howev literatur heterogen term select appropri tool identifi fs select tool common use assess fs patient cardiovascular diseas includ greatest relev cardiac surgeri present editori
|
D000073496;D006348
|
T033;T184;T046;T061
|
36,278,271
|
viscos sensit nir probe vivo imag earli stage hepat fibrosi herein viscos sensit hepat target nir fluoresc probe develop earli diagnosi hepat fibrosi import observ increas liver viscos upon ccl induc hepatotox decreas liver viscos metformin treatment confirm high clinic applic prospect
|
D008103;D008687
|
T121;T047;T109
|
36,278,269
|
residu specif n termin glycin aldehyd transform render analyt pure singl site label protein present n gli specif glyoxamid generat nativ protein isol complex mixtur result aldehyd enabl parallel instal probe purif platform render analyt pure singl site tag protein render n gli engin insulin without perturb structur receptor bind downstream signal pathway
|
D005998;D000447
|
T123;T121;T116;T109
|
36,278,256
|
porous silicon carrier endow phototherm therapeut effect synergist wound disinfect drug carrier endow phototherm effect allow drug deliveri system releas drug thermal stimuli manner addit phototherm therapi ptt also interplay therapeut drug load carrier exhibit synergist bioactiv various diseas treatment howev endow drug carrier phototherm synergist therapeut effect still challeng herein demonstr surfac modif porous silicon psi polydopamin pda could endow classic drug carrier signific phototherm effect advanc antibacteri therapi wound disinfect specif psi surfac interact cu pda complex via simpl fast surfac reduct induc deposit method form uniqu cupda coat psi microcarri cuppsi without block mesopor structur cuppsi carrier generat higher near infrar nir phototherm effici improv drug load capac owe abund function group pda stimuli respons releas antibacteri cu load curcumin cur cuppsi realiz multipl stimuli includ ph reactiv oxygen speci nir laser irradit benefit carrier intrins multimod therapi cuppsi cur platform exhibit amplifi broad spectrum synergist antibacteri effect kill staphylococcus aureus escherichia coli mild ptt temperatur c notabl combin therapi promot migrat fibroblast signific cytotox reveal cell experi vitro bacteria infect mice model effici bacteri ablat wound heal demonstr neglig side effect vivo overal ration design drug carrier phototherm therapeut effect provid novel intervent amplif wound disinfect clinic
|
D010789;D003474
|
T061;T121;T130;T109
|
36,277,989
|
predict valu analysi serum ig ig g tnf recurr multipl myeloma studi aim analyz predict valu serum ig ig g tnf recurr multipl myeloma mm
|
D014409;D009101
|
T129;T191;T116
|
36,277,988
|
lncrna dleu acceler oral cancer progress via mir prapb axi regul p mapk signal pathway oral cancer oc common cancer world long noncod rnas lncrnas shown involv cancer regul includ oral cancer oc aim studi investig role lncrna delet lymphocyt leukemia dleu oral cancer
|
D062085;D035683;D009062
|
T123;T191;T114
|
36,277,987
|
mix method investig preval influenc factor compass fatigu among midwiv differ area china explor influenc factor compass fatigu among midwiv prevent compass fatigu occur improv mental health
|
D000068376;D008880
|
T091;T097;T048
|
36,277,986
|
heart failur model establish pressur overload caus abdomin aortic contract rat heart failur complex clinic syndrom ventricular fill eject capac impair due structur function diseas heart order establish stabl heart failur model investig cardiac paramet rat abdomin aortic contract normal rat includ left ventricular posterior wall diamet lvpwd interventricular septum thick end diastol ivsd left ventricular end diastol diamet lvedd left ventricular eject fraction lvef left ventricular fraction shorten lvfs rat random divid experiment group n control group n experiment group underw modifi abdomin aortic constrict control group isol abdomin aorta without constrict result show surviv rate rat experiment group one week oper surviv rate rat control group five week oper left ventricular posterior wall diamet lvpwd interventricular septum thick end diastol ivsd experiment group increas compar control group differ statist signific p week oper lvpwd ivsd lvedd experiment group increas compar control group p lvef lvfs experiment group decreas compar control group p compar control group bnp experiment group increas signific p heart weight index left ventricular weight index rat experiment group signific higher control group p stain show myocardi cell experiment group increas volum disord cell arrang widen gap increas nuclear hyperchromia uneven stain paper provid theoret basi studi heart failur
|
D016277;D006333
|
T047;T046;T042
|
36,277,985
|
clinic efficaci safeti extracorpor shock wave lithotripsi treatment patient urinari calculi evalu clinic efficaci extracorpor shock wave lithotripsi eswl urinari calculi precaut postop complic
|
D008096;D014545
|
T061;T031
|
36,277,984
|
clinic applic anlotinib combin docetaxel safe effect treatment lung carcinoma compar clinic efficaci long term surviv anlotinib monotherapi anlotinib plus docetaxel patient lung carcinoma
|
D002277;D008175
|
T191
|
36,277,983
|
role exo rpa polymorph prognosi lung cancer patient treat platinum base chemotherapi lung cancer one major caus cancer relat mortal worldwid dna repair damag respons contribut genom instabl accompani tumor progress studi focus evalu associ dna repair polymorph exo rpa prognosi lung cancer patient receiv platinum base chemotherapi
|
D010984;D008175
|
T196;T191
|
36,277,982
|
cdx predict biomark involv immunotherapi respons suppress metastasi emt colorect cancer studi confirm caudal type homeobox cdx play tumor suppressor role colorect cancer crc prognost predict marker colorect cancer epitheli mesenchym transit emt transdifferenti process provid migratori invas properti cancer cell tumor progress howev role cdx activ emt crc maintain controversi
|
D058750;D015179
|
T191;T043
|
36,277,981
|
ganoder acid inhibit high glucos induc oxid stress extracellular matrix accumul rat glomerular mesangi cell aim investig role ganoder acid gaa glomerular mesangi cell gmcs high glucos hg
|
D050527;D005353
|
T123;T116;T025
|
36,277,980
|
analysi effect noninvas posit pressur ventil patient respiratori failur complic diabet mellitus observ clinic effect noninvas posit pressur ventil patient respiratori failur complic diabet
|
D003920;D011175;D012131
|
T061;T047;T046
|
36,277,979
|
valu mri combin afp afp l gp dcp diagnosi earli primari liver cancer investig diagnost valu magnet reson imag mri combin serum alpha fetoprotein afp alpha fetoprotein afp l golgi protein gp des carboxyprothrombin dcp earli stage primari liver cancer phc
|
D006528;D008113
|
T191
|
36,277,978
|
ythdf regul macrophag polar nf b mapk signal pathway inhibit p degrad macrophag heterogen cell polar phenotyp reader yth domain famili protein ythdf bind protein highest activ recogn disturb contain mrna process bodi reduc mrna stabil ythdf recent identifi effect rna bind protein modul inflammatori gene level within inflammatori respons howev role ythdf mm macrophag polar report establish mm macrophag polar model use bone marrow deriv macrophag found express level ythdf mm macrophag elev ythdf knockdown macrophag polar model establish qpcr elisa fac discov suppress ythdf encourag polar restrain polar macrophag ythdf silenc signific effect p express howev ythdf knockdown macrophag p express remark upregul p inhibitor pft appli reveal suppress p simultan promot ythdf silenc polar facilit macrophag polar actinomycin assay util examin mrna degrad level differ cytokin p mrna degrad ythdf deplet cell discov imped western blot analysi also impli deficit ythdf express may activ mapk nf b pathway studi ythdf induc macrophag polar promot degrad p mrna ythdf suppress macrophag polar inhibit nf b p jnk signal pathway yet p remain unaffect ythdf silenc macrophag
|
D016328;D016159
|
T129;T123;T116
|
36,277,977
|
chang cell subset serum ifn il ige level children respiratori syncyti virus capillari bronchiti clinic signific investig chang cell subset serum ifn il ige level children respiratori syncyti virus capillari bronchiti clinic signific
|
D018357;D001991
|
T047
|
36,277,976
|
explor rcbf metabol chang brain function area patient hypothyroid asl mrs techniqu studi region cerebr blood flow rcbf import brain function area metabol level brain function area patient primari hypothyroid use arteri spin label asl magnet reson spectroscopi mrs techniqu explain possibl caus brain dysfunct patient primari hypothyroid
|
D003401;D007037
|
T123;T047;T116
|
36,277,975
|
applic preoper adductor canal block coupl general anaesthesia elder patient undergo total knee arthroplasti investig clinic applic preoper adductor canal block combin general anaesthesia elder patient total knee arthroplasti
|
D019645;D009407
|
T061
|
36,277,974
|
chemic shift encod mri bone metabol marker ankylos spondyl investig feasibl correl sacroiliac joint sij fat fraction ff r marker bone metabol patient ankylos spondyl
|
D013167;D001855
|
T047
|
36,277,973
|
graph theori base degre central combin machin learn algorithm predict respons treatment antipsychot medic patient first episod schizophrenia schizophrenia scz associ disrupt function brain connect antipsychot medic primari common use treatment schizophrenia howev patient respond antipsychot medic
|
D012559;D014150
|
T121;T039;T048
|
36,277,972
|
lncrnas ac ac biomark diagnosi prognosi colorect cancer countless studi date assess specif oncogen pathway rang tumor class role n methyladenosin relat long noncod rnas lncrnas colorect cancer crc remain defin
|
D062085;D015179
|
T123;T191;T114
|
36,277,962
|
identif oxid stress relat lncrna signatur predict prognosi chemotherapi patient hepatocellular carcinoma background oxid stress play critic role oncogenesi tumor progress howev prognost role oxid stress relat lncrna hepatocellular carcinoma hcc fulli explor method use gene express data clinic data cancer genom atlas tcga databas identifi oxid stress relat differenti express lncrnas delncrna pearson correl analysi four oxid stress relat delncrna signatur construct lasso regress cox regress analys predict signatur valid kaplan meier k surviv analysi receiv oper characterist roc curv nomogram calibr plot princip compon analysi pca singl sampl gene set enrich analysi ssgsea use explor relationship signatur immun status final correl signatur chemotherapeut respons hcc patient analyz result studi four delncrna signatur prove robust independ prognost factor overal surviv os predict also play crucial role regul progress chemotherapeut respons hcc ssgsea show signatur correl infiltr level immun cell hcc patient high risk group sensit convent chemotherapeut drug includ sorafenib lapatinib nilotinib gefitinib erlotinib dasatinib pave way target delncrna associ treatment hcc patient conclus studi origin prognost signatur hcc base oxid stress relat delncrna deepen understand biolog role four key delncrna hcc laid theoret foundat choic chemotherapi
|
D006528;D062085;D008113
|
T123;T191;T114
|
36,277,960
|
egfr tm mutat detect patient non small cell lung cancer first line egfr tki therapi summari result three year period comparison commerci avail detect kit egfr mutat non small cell lung cancer nsclc offer potenti therapeut target tyrosin kinas inhibitor tki therapi major case howev eventu develop therapi resist main acquir egfr tm mutat recent third generat tkis introduc overcom tm mutat relat resist cell free circul tumor dna liquid biopsi emerg valuabl altern method tm mutat detect patient follow tissu biopsi obtain analysi studi summar experi super arm egfr mutat detect kit amoydx sampl nsclc patient year period hungari compris plasma non plasma sampl also compar perform two commerci avail detect kit coba egfr mutat test v roch super arm egfr mutat detect kit amoydx activ egfr mutat detect amoydx kit primari tumor sampl tm mutat identifi sampl contain activ egfr mutat detect rate tm mutat depend dna concentr plasma sampl consider improv mutat detect rate second subsequ plasma sampl concord egfr activ mutat detect two method tm mutat detect amoydx kit howev show overal higher detect rate tm mutat compar coba kit p tm mutat detect patient plasma sampl avail analysi detect rate non plasma sampl activ egfr detect plasma sampl detect rate tm mutat although non plasma sampl provid superior tm mutat detect rate found liquid biopsi offer valuabl tool tm mutat detect tissu biopsi avail altern liquid biopsi use screen test biopsi consid case wild type result
|
D002289;D000074141;D008175
|
T191;T114
|
36,277,959
|
overexpress dehydrogenasereductas predict poor respons concurr chemoradiotherapi poor prognosi rectal cancer patient object reduc risk locoregion recurr addit neoadjuv concurr chemoradiotherapi ccrt recommend surgic manag rectal cancer patient howev despit ident tumor histolog individu patient respons neoadjuv ccrt vari great accord comprehens molecular character use predict ccrt efficaci instant need method pearson chi squar test util correl dehydrogenasereductas dhrs express clinicopatholog featur surviv curv creat appli kaplan meier method log rank test conduct compar prognost util high low dhrs express group multivari cox proport hazard regress analysi appli identifi independ prognost biomark base variabl prognost util univari level result util public transcriptom dataset identifi dhrs gene consider upregul gene relat epitheli cell differenti go among rectal cancer patient ccrt resist employ immunohistochem stain also demonstr high dhrs immunoexpress consider associ aggress clinic cours ccrt resist rectal cancer cohort among variabl prognost util univari level high dhrs immunoexpress independ unfavor prognost three endpoint p multivari analysi addit appli bioinformat analysi also link dhrs unrev function keratan sulfat mucin synthesi may implic ccrt resist conclus altogeth dhrs express may serv help predict prognost biomark assist decis make rectal cancer patient underw neoadjuv ccrt
|
D007632;D012004
|
T123;T191;T109
|
36,277,903
|
causal role sleep durat osteoporosi cardiometabol diseas mendelian random studi sleep durat suggest associ osteoporosi cardiometabol diseas unknown associ causal confound two sampl mendelian random mr studi includ largest genom wide associ studi gwass associ sleep durat outcom measur osteoporosi cardiometabol diseas final singl nucleotid polymorph snps associ short sleep durat snps associ long sleep durat obtain genom wide signific p use instrument variabl genet predisposit short sleep durat strong associ increas risk coronari arteri diseas beta estim confid interv ci standard error se p valu heart failur beta estim ci se p valu confirm sensit analys short long sleep durat may reduc estim bone miner densiti ebmd beta estim ci se p valu short sleep durat beta estim ci se p valu long sleep durat limit evid associ sleep durat fractur type diabet atrial fibril fast glucos fast insulin hbac studi provid robust evid short sleep durat causal associ high risk coronari arteri diseas heart failur suggest short sleep durat avoid prevent two cardiovascular diseas short long sleep durat show mr associ reduc ebmd indic short long sleep durat may prevent reduc incid osteoporosi
|
D003924;D003324;D002318;D010024;D012893;D006333;D061385
|
T121;T047;T046;T048
|
36,277,901
|
compound shuganjieyu capsul cyp enzym activ evalu potenti drug drug interact shuganjieyu capsul establish chronic unpredict mild stress cum depress model combin cocktail probe substrat method
|
D019388;D003577
|
T126;T116
|
36,277,900
|
clinic studi treatment recurr chiari type malform syringomyelia base dynam cerebrospin fluid combin dynam cerebrospin fluid studi investig clinic effect syringomyelia combin fourth ventricl subarachnoid shunt fvss recurr chiari type malform cranial fossa decompress foramen magnum decompress fmd
|
D013595;D001139
|
T019;T047
|
36,277,899
|
effect rigid nonrigid connect miniscrew anchorag tooth dynam efficaci advers effect maxillari second molar protract finit element analysi direct rigid indirect nonrigid indirect absolut anchorag use temporari anchorag devic tad mini implantsminiscrew provid promis opportun challeng yet common orthodont tooth movement molar protract rigid rectangular wire ligatur wire common method attach tooth miniscrew indirect anchorag aim provid comparison rigid connect wire term stress miniscrew anchorag loss risk root resorpt use finit element analysi fea
|
D052280;D012391
|
T061;T047
|
36,277,898
|
machin learn approach use xgboost predict lung metastasi patient ovarian cancer liver metastasi lm independ risk factor affect prognosi patient ovarian cancer howev still lack predict studi develop limit gradient enhanc xgboost predict risk lung metastasi newli diagnos patient ovarian cancer therebi improv predict effici patient method data patient diagnos ovarian cancer surveil epidemiolog final result seer databas retrospect collect xgboost algorithm use establish lung metastasi model patient ovarian cancer perform predict model test area curv auc receiv oper characterist curv roc
|
D008175;D010051
|
T191
|
36,277,897
|
construct analysi cerna network relat salt sensit hypertens salt sensit hypertens ssh independ risk factor cardiovascular diseas howev mechan ssh clear studi aim construct compet endogen rna cerna network relat ssh
|
D062085;D035683;D006973
|
T123;T047;T114
|
36,277,896
|
dracocephalum kotschyi boiss vitro efficaci growth apoptosi induct leishmania major promastigot dracocephalum kotschyi boiss plant general use modern medicin treat mani human ill also use prevent tumor cell prolifer throughout world studi object evalu plant vitro efficaci growth apoptosi induct leishmania major promastigot essenti oil extract test follow collect identif kotschyi essenti oil analyz use gc ms analyz promastigot l major cultur rpmi media mtt assay flow cytometri analysi carri promastigot enter log phase differenti viabl necrot apoptot treat untreat promastigot flow cytometri method doubl stain annexin v fluo propidium iodid pi use given result obtain phytochem identifi essenti oil plant copaen methyl geran gerani carvon main substanc essenti oil kotschyi inhibit prolifer l major promastigot gml gml gml respect h h h cell divid four quadrat base cell phase use flow cytometri approach doubl stain annexin v fluo propidium iodid pi necrosi q late apoptosi q earli apoptosi q viabl q quadrat overal appar differ concentr induc cell apoptosi promastigot observ light microscop magnif show differ dose kotschyi essenti oil caus appar alter treat promastigot work kotschyi essenti oil induc program death l major promastigot studi open mani research perspect investig mechan action product phytomedicin base plant
|
D018320;D019686;D009822
|
T002;T204;T109
|
36,277,895
|
peelu salvadora oleoid decn unexplor medicin fruit miner antioxid phytochem peelu salvadora oleoid decn fruit well known nutrit medicin valu current studi analyz chemic composit salvadora oleoid fruit fresh peelu fruit harvest physicochem properti proxim composit macro micronutri phytochem properti determin moreov ethanol methanol fruit extract analyz physicochem properti peelu fruit seem potenti sourc essenti macro nitrogen n phosphorus p potassium k calcium ca magnesium mg micronutri zinc zn manganes mn iron fe copper cu fruit signific biochem properti total solubl solid tss total acid ta tss ta ratio appreci moistur crude fiber ash content fruit extract demonstr signific higher antioxid phenol ascorb acid content carotenoid phytochem screen fruit reveal presenc coumarin flavonoid phlobatannin tannin terpenoid physicochem sensori evalu extract indic potenti vivo studi trial peelu fruit found good sourc miner nutrient proxim content vitamin ascorb acid carotenoid phytochem total phenol sand antioxid content pharmaceut import metabolit use function drink
|
D000975;D032121
|
T123;T121;T044;T039;T002
|
36,277,894
|
analyz mechan salb regul sirt inhibit nlrp amelior effect tubulogastr junction tumor lesion complic myocardi injuri object research investig mediat impact salvianol acid b salb sirt signal pathway mechan inhibit nod like receptor protein nlrp well examin salb affect myocardi injuri brought tumor lesion junction tube stomach establish integr stomach tube tumor lesion rat combin experiment rat model studi establish normal group model group differ salb dose group group cell cell activ cell apoptosi determin compar use colorimetri enzym link immunosorb method lactat dehydrogenas ldh interleukin beta level measur dcfh da fluoresc probe appli identifi intracellular reactiv oxygen speci ros western blot use determin nlrp caspas apoptosi relat spot protein asc group cell sirt signal pathway relat sirt phosphoryl amp protein activ kinas p ampk amp protein activ kinas ampk peroxisom prolifer activ receptor coactiv pgc protein express use accord final find salb mediat sirt signal pathway benefici impact upregul sirt p ampkampk pgc protein express salb posit affect downregul nlrp inflammasom relat protein caspas asc protein express suggest salb may inhibit activ nlrp inflammasom induc oxid stress activ sirtampkpgc signal pathway play antimyocardi injuri effect
|
D056564;D009369
|
T191;T126;T116
|
36,277,893
|
identif rps biomark ferroptosi acut kidney injuri paper aim explor novel ferroptosi relat biomark acut kidney injuri aki
|
D000079403;D058186
|
T047;T037;T043
|
36,277,892
|
develop deep learn techniqu featur analysi clinic imag integr cann comput tomographi extens use method detect diseas subject basic comput aid tomographi depend artifici intellig reveal signific smart health care monitor system owe secur privat issu analyz comput tomographi dataset becom tedious process studi put forward convolut autoencrypt deep learn neural network assist unsupervis learn techniqu carri various experi propos method produc better result compar tradit method efficaci solv issu relat artifici imag descript henc convolut autoencod wide use measur lump bronchi unsupervis machin learn extract featur use various applic
|
D000077321
|
T066
|
36,277,891
|
molecular mechan antifung resist mucormycosi mucormycosi one among life threaten fungal infect high morbid mortal uncommon rare infect target peopl alter immun lethal infect induc fungi belong mucoral famili progress natur incid increas recent decad owe rise immunocompromis patient diseas manag involv multimod strategi includ earli administr drug surgic remov infect tissu among antifung azol amphotericin b remain gold standard drug choic initi treatment order mucoral develop high level resist avail system antifung drug efficaci still remain par deciph molecular mechan behind antifung resist mucormycosi would add vital inform avail antifung armamentarium design novel therapi therefor review discuss mechan behind mucormycosi antifung resist moreov review also highlight basic mechan action antifung drug resist landscap expect augment futur treatment strategi
|
D009091;D009090
|
T047;T004
|
36,277,890
|
adipos deriv stem cell exosom inhibit hypertroph scare format regul thtreg cell balanc aim reveal role adc exo secret inflammatori factor th regulatori treg cell differenti nave cd cell hypertroph scare format matur explor elisa qrt pcr immunoblot perform assay local inflammatori factor il il il tnf transcript factor ror foxp scare tissu patient mice wound model treat without adc exo immunohistochemistri stain immunoblot conduct assay extracellular matrix ecm deposit vitro vivo result show il il il tnf ror foxp increas mrna protein level hypertroph scare compar atroph scare normal skin nave cd cell treat adc exo vitro produc signific less il il tnf ror il foxp mrna protein level addit mice adsc exo treat group demonstr less collagen deposit decreas il tnf ror increas il foxp product
|
D050378;D055354
|
T026;T025
|
36,277,888
|
beyond psychopatholog approach studi relationship bodi dissatisfact suicid moder mediat analysi paper provid comprehens review literatur date bodi dissatisfact suicid moder mediat regress analysi suggest relationship two variabl mediat depress anxieti impuls control self esteem hopeless relationship moder gender ethnic socioeconom status implic mental health practition discuss relat manag strategi bodi dissatisfact suicid risk anoth find show psycholog distress signific effect perform achiev serv mediat variabl effect social justic perform achiev studi focus effect psycholog distress perform achiev human resourc context islam microfin institut besid explain model studi focus one point view grand theori ie social exchang theori studi provid inform altern strategi manag minim risk psycholog distress improv perform achiev islam microfin institut apart studi also provid overview manag social exchang relationship context organ could well maintain studi examin effect psycholog distress perform achiev human resourc context islam microfin institut studi also specif examin role formal justic social justic anteced psycholog distress eventu studi use perspect social exchang theori first time explain psycholog distress model perform achiev human resourc
|
D000079182;D013405;D001523
|
T033;T055;T048
|
36,277,887
|
ultrason imag cardiovascular diseas base imag processor analysi hard plaqu characterist cardiovascular diseas detect analysi use ultrason imag expel error manual clinic trial precis outcom requir combin smart comput system intellig imag processor diseas characterist analyz base configur precis tune process devic articl characterist extract techniqu cet use knowledg learn kl introduc improv analysi precis propos method requir optim select diseas featur train similar dataset improv characterist extract diseas attribut accuraci identifi use standard knowledg updat imag data featur segment use variabl processor configur prevent fals rate fals rate due unidentifi plaqu characterist result weak knowledg updat therefor segment data extract unanim perform prevent featur mislead knowledg base updat use extract identifi plaqu characterist consecut imag analysi processor configur manag use updat knowledg characterist improv precis propos method verifi use precis characterist updat train rate extract ratio time factor
|
D002318;D058226
|
T047;T046;T020;T031
|
36,277,886
|
vitro antimitot hypoglycem effect studi acut toxic assess aqueous organ extract chamaerop humili l var argentea andr background chamaerop humili l var argentea andr plant wide spread region taza north east morocco use tradit phytotherapi cancer diabet inflamm cardiovascular respiratori diseas treatment digest disord object method object work contribut first studi vitro antimitot potenti phytotest lepidium sativum evalu vitro antidiabet activ three enzym amylas glucosidas galactosidas nine aqueous organ extract prepar leav chamaerop humili addit correl studi carri chemic composit antimitot antidiabet activ chamaerop humili leav test acut toxic decoct extract ethanol extract result result antimitot activ show decoct extract show higher inhibitori activ aqueous extract ic gml organ extract ethanol extract ethanol macer express highest valu cell growth inhibit test ic gml statist nonsignific differ regard antidiabet activ decoct show higher inhibitori activ aqueous extract amylas ic gml glucosidas gml galactosidas gml ethanol extract also reveal highest inhibitori activ amylas ic gml glucosidas gml galactosidas gml strong correl record antimit activ inhibitori capac galactosidas two activ chemic composit chamaerop humili leav acut toxic studi show decoct ethanol extract weak toxic ld greater equal mgkg conclus chamaerop humili could becom good sourc tradit herbal medicin
|
D050256;D028023
|
T121;T002
|
36,277,884
|
comput clue immunogen hotspot plasmodium falciparum erythrocyt stage vaccin candid antigen silico approach malaria pernici parasit infect plasmodium falciparum virul speci substanti morbid mortal worldwid present silico investig perform reveal biophys characterist immunogen epitop blood stage protein p falciparum use comprehens immunoinformat approach aim various web server employ predict subcellular local antigen allergen solubl physicochem properti posttransl modif site ptms presenc signal peptid transmembran domain moreov structur analysi secondari model predict perform stabl protein respect final human helper lymphocyt htl epitop predict use hla refer set iedb server screen term antigen allergen ifn induct well popul coverag also multiserv b cell epitop predict done subsequ screen antigen allergen solubl altogeth protein show appropri antigen abund ptms mani b cell htl epitop could direct futur vaccin studi context multiepitop vaccin design
|
D017780;D016778
|
T129;T047;T121
|
36,277,883
|
associ risk esophag cancer type diabet mellitus updat meta analysi larg amount public report associ incid esophag cancer ec type diabet mellitus tdm past decad howev paper result inconsist relationship tdm incid ec therefor object meta analysi determin relationship tdm risk ec includ histolog type esophag adenocarcinoma eadc esophag squamous cell carcinoma escc
|
D004938;D003924;D000077277;D000230
|
T047;T191
|
36,277,882
|
subtyp classif immun infiltr prognosi analysi lung adenocarcinoma base pyroptosi relat gene effect pyroptosi relat gene prgs tumor microenviron tme lung adenocarcinoma luad remain unclear thus studi aim evalu prognost valu prgs patient luad elucid role tme effect immunotherapi transcriptom clinic data obtain cancer genom atlas gene express omnibus databas gse gse patient luad classifi use consist cluster differ tme type determin use estim cibersort algorithm prgs screen use univari regress analysi prognost risk model construct use lasso regress analysi tumor mutat burden tumor immun dysfunct exclus algorithm use predict therapeut sensit luad patient evalu potenti therapeut intervent use gdsc databas luad patient cluster signific shorter overal surviv progress free surviv rate lower immun score higher infiltr follicular helper cell cluster use five prgs classifi patient luad differ risk group found high risk group sensit immunotherapi howev immun relat pathway inhibit may relat tumor metabol reprogram last identifi sever potenti therapeut drug applic low risk patient less sensit immunotherapi overal find show prgs use predict prognosi may aid develop person therapeut strategi luad patient
|
D008175;D000077192
|
T191
|
36,277,881
|
applic provoc function test diagnosi rotat cuff muscl injuri best univers athlet rotat cuff diseas extern intern imping syndrom low shoulder stabil various type trauma overus injuri relat sport activ order check symptom patient disabl shoulder pain clinician use differ method diagnost imag assess research aim evalu whether differ provoc function test pft ultrasonograph us test muscl within rotat cuff elit collegi athlet patient n recruit univers team sport select test standard us examin shoulder five pfts speed test neer test hawkin test lift test yergason test base vas pain assess scale subject pain taken process work subject presenc pain exclud process us examin conduct use voluson apparatus linear probe frequenc rang mhz chi squar test show signific differ pft occurr shoulder muscl tendin follow variabl speed test subscapulari tendin p speed test infraspinatus tendin p neer test bicep brachii caput longum tendin p neer test supraspinatus tendin p neer test infraspinatus tendin p lift test subscapulari tendin p yergason test bicep brachii caput longum tendin p yergason test subscap tendin p greatest effect differ observ neer test bicep brachii caput longum tendin effect describ medium small case conclud function test good predictor soft tissu chang muscl rotat cuff shoulder monitor analysi need larger number athlet
|
D000070636;D052256
|
T033;T047;T037
|
36,277,880
|
meta analysi matrix metalloproteinas risk cardiovascular neurodegen diseas investig risk cardiovascular neurodegen diseas induc matrix metalloproteinas mmps meta analysi
|
D019636;D002318
|
T047
|
36,277,879
|
network pharmacolog base explor intervent qinghao biejia decoct inflamm carcinoma transform process chronic liver diseas via mapk pikakt pathway chronic liver diseas cld slow develop long term diseas caus serious damag liver thus far associ viral hepat non alcohol fatti liver diseas nafld alcohol liver diseas ald hepat fibrosi hf liver cirrhosi lc liver cancer qinghao biejia decoct qbd classic ancient chines herbal prescript strong immun enhanc anti inflammatori anti tumor effect studi use network pharmacolog approach investig molecular mechan qbd inflamm carcinoma transform process chronic liver diseas two key drug target mapk pikca screen use network pharmacolog molecular dock techniqu reveal dihydroartemisinin artesun nicotinoylisolineolon caffeic acid diincarvilon activ ingredi involv qbd mechan main signal pathway involv pik akt signal pathway mapk signal pathway summari result indic qbd affect inflammatori transform chronic liver diseas mapk pikca signal pathway mapk pikakt data provid research direct investig mechan under inflamm carcinoma transform process qbd chronic liver diseas
|
D031172;D004365;D065626;D002277
|
T123;T121;T191;T047;T002
|
36,277,878
|
effect clopidogrel rehabilit cardiac protein kinas c cardiac heat shock protein ci miri rat model order investig effect clopidogrel rehabilit level cardiac protein kinas c pkc cardiac heat shock protein hsp cardiac index ci rat myocardi ischemia reperfus injuri miri sixti wistar rat random divid three group sham oper group model group clopidogrel group rat group clopidogrel group given clopidogrel gavag sham oper group model group given amount normal salin gavag experiment result show compar model group clopidogrel group clear horizont line cell edema myocardi infarct rate creatin kinas mb ck mb malondialdehyd mda model group clopidogrel group control sham oper group signific increas
|
D015428
|
T046
|
36,277,877
|
connect high myopia patient mir mir express level aqueous studi visual acuiti myopia goe far beyond inconveni bring prevail vision threaten eye diseas especi asia aberr express mir mir critic accur diagnosi good prognosi precis respons predict myopia paper aim examin potenti contribut mir mir pax high myopia hm first aqueous sampl taken exclus hm eye exclus cataract eye next generat sequenc bioinformat analysi rna sampl one use twenti sampl use rt qpcr mirna total found hm eye matur mirna new mirna show differenti express express hsa mir p hsa let p hsa mir p identifi use rt qpcr mir mir may link develop myopia serv possibl biomark notabl high express atrial tissu hm patient find may help deepen understand mechan behind high express mir mir atrial tissu patient hm
|
D035683;D009216;D014792
|
T201;T123;T047;T114
|
36,277,876
|
motion lumbar endplat degen lumbar scoliosi patient differ cobb angl vivo reflect biomechan lumbar disc evalu influenc degen lumbar scoliosi dls differ cobb angl degen disc rang motion rom lumbar endplat function weight bear activ vivo summari background dls data might influenc spinal stabil rang motion spine alter lumbar segment motion thought relat disc degener howev date data report motion pattern lumbar endplat patient dls vivo
|
D012600;D055959
|
T047;T190
|
36,277,875
|
new algorithm tradit chines medicin protect intang cultur heritag base big data deep learn tradit chines medicin tcm summari diagnosi treatment experi form work peopl long term struggl diseas import protect intang cultur heritag tcm extract valuabl knowledg accur conveni massiv medic record tcm one import issu current research develop tcm due larg amount data tcm medic record mani featur attribut divers pattern exist classif technolog high comput complex low mine effici poor univers therefor paper propos quantifi medic record tcm obtain main symptom accord improv hierarch cluster featur select algorithm paper also propos support vector machin svm classif method use improv particl swarm algorithm classifi tcm inform improv effici accuraci tcm inform classif also discov potenti dialect symptom pattern diagnosi treatment intang cultur heritag protect tcm develop sustain paper show inform acquisit accuraci improv algorithm high improv algorithm use accuraci inform mine tcm highest lowest use improv algorithm accuraci rate inform mine tcm highest lowest seen use improv algorithm mine tcm inform quick process effect inform
|
D008516;D000077321
|
T060;T091;T066
|
36,277,874
|
studi serum anti mullerian hormon diagnosi ovarian reserv function patient prematur ovarian insuffici explor diagnost valu serum anti mullerian hormon amh patient prematur ovarian insuffici poi prematur ovarian failur pof
|
D065851;D016649
|
T047;T042
|
36,277,853
|
prepar effect narrat evalu medic school perform evalu mspe aamc medic school perform evalu mspe task forc issu recommend standard mspe address qualiti written narrat document narrat evalu hamper code word polit rhetor bias detriment student address aamc group student affair group educ affair conven expert group consid state narrat mspe develop resourc improv qualiti
|
D004501;D000073978
|
T065;T080
|
36,277,730
|
higher scan frequenc correl less fear hypoglycemia type diabet patient use iscgm frequent scan intermitt scan continu glucos monitor iscgm devic associ improv glycem indic limit data avail correl fear hypoglycemia foh establish factor affect qualiti life glycem control type diabet tdm
|
D003922;D007003
|
T047
|
36,277,729
|
lower bile acid independ risk factor renal outcom patient type diabet mellitus biopsi proven diabet kidney diseas abnorm glucolipid metabol critic mechan involv progress diabet kidney diseas dkd bile acid essenti role regul glucolipid metabol studi investig clinicopatholog characterist dkd patient differ bile acid level explor relationship bile acid renal outcom dkd patient
|
D003928;D003924;D007676
|
T047
|
36,277,728
|
camp specif phosphodiesteras b isoform differenti express human testi leydig cell tumor cyclic adenosin monophosphateprotein kinas camppka signal pathway master regul endocrin tissu function level compartment amplitud camp respons fine regul phosphodiesteras pdes pde respons camp hydrolysi express character steroidogen cell type rodent includ adren leydig cell rodent howev scarc data current avail human demonstr human leydig cell express pdea pdeb isoform interest found express pdeb pdea increas transform leydig cell leydig cell tumor lcts compar non tumor cell immunofluoresc analys reveal pdea also high express specif spermatogen stage protein detect spermatogonia accumul nearbi form acrosom tran golgi apparatus spermatocyt spermatid follow fate organell later stage transloc caudal part cell taken togeth find suggest specif pool camp isar regul pdea spermiogenesi point possibl new role pde isoform key event govern differenti matur human sperm pdeb involv leydig cell transform
|
D015105;D007984
|
T191;T126;T116
|
36,277,727
|
posttransl modif pathogenesi pcos polycyst ovari syndrom pcos lifelong reproduct metabol psychiatr disord affect women associ signific increas lifetim risk concomit diseas includ type diabet psychiatr disord gynecolog cancer posttransl modif ptms play import role chang protein function necessari maintain cellular viabil biolog process thus maladjust lead diseas grow evid suggest associ pcos posttransl modif articl main review research status phosphoryl methyl acetyl ubiquitin well role molecular mechan develop pcos addit briefli summar research clinic trial pcos therapi advanc understand agent use target phosphoryl methyl acetyl ubiquitin ptm type provid idea futur research mechan pcos also idea pcos treatment therapeut potenti
|
D011085;D003924
|
T047
|
36,277,726
|
leptin environment temperatur determin bone marrow adipos femal mice bone marrow adipos tissu bmat level higher distal femur metaphysi femal mice hous thermoneutr c mice hous c abdomin white adipos tissu wat mass serum leptin level perform two experi explor role increas leptin temperatur enhanc accrual bmat first supplement week old femal cblj b mice leptin week gd use subcutan implant osmot pump control consist ad libitum ad lib fed mice mice pair fed match food intak leptin supplement mice mice maintain c durat treatment necropsi serum leptin leptin supplement mice differ ad lib mice suggest suppress endogen leptin product support ucp express bat percent bodi fat abdomin wat mass lower leptin supplement mice leptin supplement mice also lower bmat higher bone format distal femur metaphysi compar ad lib group chang replic pair feed second experi bmat respons evalu week old femal b wild type wt leptin defici obob leptin treat gd obob mice hous c week durat treatment compar mice sacrif baselin c bmat increas obob mice well wt mice indic leptin independ respons increas temperatur howev infus obob mice leptin dose rate neglig effect either energi metabol serum leptin level attenu increas bmat summari increas hous temperatur increas leptin independ oppos effect bmat mice
|
D020738;D001853
|
T125;T023;T116;T024
|
36,277,725
|
progress type diabet mellitus gestat diabet mellitus diagnos iadpsg criteria systemat review meta analysi estim progress rate type diabet mellitus tdm women gestat diabet mellitus gdm diagnos intern associ diabet pregnanc studi group iadpsg criteria
|
D016640;D003924;D011236;D011254
|
T047
|
36,277,724
|
effect covid pandem diagnosi treatment thyroid cancer brazil covid pandem delay diagnosi treatment follow visit patient thyroid cancer howev magnitud restrict affect brazilian health care still unknown
|
D000086382;D013964
|
T047;T191;T067
|
36,277,723
|
five immun relat gene diagnost marker endometriosi correl immun infiltr endometriosi em chronic diseas caus dysmenorrhea chronic pelvic pain infertil among symptom em diagnosi often delay compar chronic diseas current accur easili access non invas diagnost tool therefor import elucid mechan em explor potenti biomark diagnost tool accur diagnosi treatment present studi comprehens analyz differenti express immun infiltr interact em relat gene three homo sapien dataset result identifi differenti express gene deg associ em gene ontolog analysi show chang main focus posit regul endometri cell prolifer cell metabol extracellular space em involv integrin complement activ folic acid metabol interleukin lipid signal pathway lasso regress model establish use immun deg area curv intern dataset extern dataset five gene diagnost valu ackr lmnb mfap nmu semac screen macrophag activ mast cell neutrophil natur killer cell follicular helper cell cd cd cell protein protein interact network base immun deg construct ten hub gene highest score identifi result may provid framework develop patholog molecular network em
|
D004715
|
T047;T191
|
36,277,722
|
curv match predict growth patient receiv growth hormon therapi interpret explain method curv match may use predict growth outcom use data patient whose growth curv resembl new patient growth hormon defici ghd born small gestat age sga aim investig valid curv match predict growth patient ghd born sga receiv recombin human growth hormon r hgh height data collect month treatment extract easypod connect ecosystem easypod connect observ studi select patient height standard deviat score hsds age start includ match databas consist patient month hsds obtain broken stick method imput standard deviat sd obtain observ minus predict hsds error base match patient within match databas data avail patient match databas patient hsds measur observ databas hsds measur avail error sd one year predict approxim correspond cm cm cm year age respect indic age treatment start vs year small impact error sd patient born sga patient age year treatment start general slight lower valu conclud curv match simpl valid techniqu predict growth patient ghd born sga
|
D019382;D004393
|
T121;T116;T125;T047;T101
|
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